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Illumina Body Map 2: averaged replicates
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Results for NR1H4
Z-value: 1.06
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Transcription factors associated with NR1H4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1H4 | hg19_v2_chr12_+_100867733_100867750 | 0.18 | 3.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1H4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.2 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.1 | 6.2 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 1.8 | 5.4 | GO:0002728 | negative regulation of natural killer cell cytokine production(GO:0002728) |
| 1.6 | 4.8 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 0.6 | 4.5 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.8 | 3.8 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 0.6 | 3.8 | GO:0002727 | natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) |
| 0.9 | 3.6 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 1.0 | 3.1 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.1 | 2.2 | GO:0051014 | actin filament severing(GO:0051014) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.6 | 5.0 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 4.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 4.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 3.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.3 | 3.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 2.8 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.2 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 2.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 2.1 | GO:0042101 | T cell receptor complex(GO:0042101) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 4.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 4.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 4.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 3.8 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.9 | 3.6 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.1 | 3.2 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 2.3 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.1 | 2.2 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.1 | 2.2 | GO:0005522 | profilin binding(GO:0005522) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.4 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 4.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.3 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 2.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.0 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 2.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 1.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.2 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 1.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.6 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 4.7 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 3.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 3.6 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 2.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 2.1 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.0 | 1.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 1.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |