ISMARA results: NR1I3

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Illumina Body Map 2: averaged replicates

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Results for NR1I3

Z-value: 0.70

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Transcription factors associated with NR1I3

Gene Symbol	Gene ID	Gene Info
NR1I3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000143257.7	nuclear receptor subfamily 1 group I member 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR1I3	hg19_v2_chr1_-_161207986_161208000	0.26	1.5e-01	Click!

Activity profile of NR1I3 motif

Sorted Z-values of NR1I3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_57766075 Show fit	2.54	ENST00000371030.2	ZNF831 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 831
chr10_-_73848764 Show fit	1.69	ENST00000317376.4 ENST00000412663.1	SPOCK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr13_-_20806440 Show fit	1.53	ENST00000400066.3 ENST00000400065.3 ENST00000356192.6	GJB6 Ensembl NCBI GeneCards UniProt NextProt Show fit	gap junction protein, beta 6, 30kDa
chr22_+_42372764 Show fit	1.39	ENST00000396426.3 ENST00000406029.1	SEPT3 Ensembl NCBI GeneCards UniProt NextProt Show fit	septin 3
chr7_-_31380502 Show fit	1.30	ENST00000297142.3	NEUROD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal differentiation 6
chr1_+_153330322 Show fit	1.23	ENST00000368738.3	S100A9 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A9
chr11_+_105480740 Show fit	1.22	ENST00000393125.2	GRIA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 4
chr4_-_57524061 Show fit	1.15	ENST00000508121.1	HOPX Ensembl NCBI GeneCards UniProt NextProt Show fit	HOP homeobox
chr12_-_75601778 Show fit	1.12	ENST00000550433.1 ENST00000548513.1	KCNC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium voltage-gated channel, Shaw-related subfamily, member 2
chr14_-_50506589 Show fit	1.06	ENST00000553914.2	RP11-58E21.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-58E21.3

Showing 1 to 10 of 140 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	1.7	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2	1.5	GO:0070383	DNA cytosine deamination(GO:0070383)
0.0	1.5	GO:0051602	response to electrical stimulus(GO:0051602)
0.0	1.3	GO:0021542	dentate gyrus development(GO:0021542)
0.0	1.3	GO:0046710	GDP metabolic process(GO:0046710) receptor localization to synapse(GO:0097120)
0.4	1.2	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0	1.2	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.1	1.1	GO:0038060	nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1	1.0	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)

Showing 1 to 10 of 48 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	1.7	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	1.5	GO:0005922	connexon complex(GO:0005922)
0.0	1.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	1.1	GO:0030673	axolemma(GO:0030673)
0.0	0.9	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2	0.8	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	0.8	GO:0055028	cortical microtubule(GO:0055028)
0.1	0.7	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.7	GO:0042613	MHC class II protein complex(GO:0042613)

Showing 1 to 10 of 20 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1	2.0	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.1	1.7	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.2	1.5	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	1.3	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	1.3	GO:0005158	insulin receptor binding(GO:0005158)
0.2	1.2	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	1.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.3	0.8	GO:0070119	ciliary neurotrophic factor binding(GO:0070119)
0.0	0.8	GO:0051011	microtubule minus-end binding(GO:0051011)

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
1.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.0	PID EPHA FWDPATHWAY	EPHA forward signaling
0.8	ST STAT3 PATHWAY	STAT3 Pathway
0.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	1.5	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	1.1	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	1.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.8	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.8	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.7	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.4	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.2	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins

Showing 1 to 10 of 10 entries

Results for NR1I3

Z-value: 0.70

Motif logo

Transcription factors associated with NR1I3

Activity-expression correlation:

Activity profile of NR1I3 motif

Sorted Z-values of NR1I3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: