ISMARA results: SREBF2

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Illumina Body Map 2: averaged replicates

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Results for SREBF2

Z-value: 1.39

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Transcription factors associated with SREBF2

Gene Symbol	Gene ID	Gene Info
SREBF2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000198911.7	sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SREBF2	hg19_v2_chr22_+_42229100_42229146	0.15	4.1e-01	Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_56150184 Show fit	4.76	ENST00000394554.1	EFEMP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	EGF containing fibulin-like extracellular matrix protein 1
chr12_-_53343602 Show fit	4.03	ENST00000546897.1 ENST00000552551.1	KRT8 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 8
chr6_+_151561085 Show fit	3.37	ENST00000402676.2	AKAP12 Ensembl NCBI GeneCards UniProt NextProt Show fit	A kinase (PRKA) anchor protein 12
chr12_-_53343633 Show fit	3.26	ENST00000546826.1	KRT8 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 8
chr9_+_96928516 Show fit	3.16	ENST00000602703.1	RP11-2B6.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-2B6.3
chr12_-_91505608 Show fit	3.01	ENST00000266718.4	LUM Ensembl NCBI GeneCards UniProt NextProt Show fit	lumican
chr12_-_53343560 Show fit	2.91	ENST00000548998.1	KRT8 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 8
chr7_-_84816122 Show fit	2.78	ENST00000444867.1	SEMA3D Ensembl NCBI GeneCards UniProt NextProt Show fit	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr19_+_55591743 Show fit	2.68	ENST00000588359.1 ENST00000245618.5	EPS8L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	EPS8-like 1
chr6_-_32152064 Show fit	2.51	ENST00000375076.4 ENST00000375070.3	AGER Ensembl NCBI GeneCards UniProt NextProt Show fit	advanced glycosylation end product-specific receptor

Showing 1 to 10 of 83 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	10.2	GO:0051599	response to hydrostatic pressure(GO:0051599)
2.5	7.4	GO:1904603	regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.5	4.8	GO:0048050	post-embryonic eye morphogenesis(GO:0048050)
1.1	3.4	GO:0060981	cell migration involved in coronary angiogenesis(GO:0060981)
0.2	3.4	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.1	3.2	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.3	3.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	2.8	GO:0050919	negative chemotaxis(GO:0050919)
0.2	2.7	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	2.4	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)

Showing 1 to 10 of 35 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	6.6	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	5.4	GO:0001650	fibrillar center(GO:0001650)
0.3	4.0	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	2.7	GO:0043202	lysosomal lumen(GO:0043202)
0.0	2.4	GO:0032587	ruffle membrane(GO:0032587)
0.6	1.9	GO:1990666	PCSK9-LDLR complex(GO:1990666)
0.1	1.7	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	1.7	GO:0043218	compact myelin(GO:0043218)
0.5	1.6	GO:0019008	molybdopterin synthase complex(GO:0019008)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.2	GO:0097110	scaffold protein binding(GO:0097110)
2.5	7.4	GO:1904599	advanced glycation end-product binding(GO:1904599)
1.0	4.8	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.8	3.4	GO:0005019	platelet-derived growth factor beta-receptor activity(GO:0005019)
0.2	3.4	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	3.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	2.8	GO:0038191	neuropilin binding(GO:0038191)
0.2	2.7	GO:0042608	T cell receptor binding(GO:0042608)
0.1	2.4	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	1.9	GO:0004364	glutathione transferase activity(GO:0004364)

Showing 1 to 10 of 28 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.2	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	7.4	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	6.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	6.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	3.4	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	3.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.8	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	1.7	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	1.7	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	1.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.4	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	4.2	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.1	3.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	2.4	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	1.9	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	1.8	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.6	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	1.3	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	1.1	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport

Showing 1 to 10 of 14 entries

Results for SREBF2

Z-value: 1.39

Motif logo

Transcription factors associated with SREBF2

Activity-expression correlation:

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: