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Illumina Body Map 2

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Results for ISX

Z-value: 0.79

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Transcription factors associated with ISX

Gene Symbol Gene ID Gene Info
ENSG00000175329.8 intestine specific homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISXhg19_v2_chr22_+_35462129_354621560.029.3e-01Click!

Activity profile of ISX motif

Sorted Z-values of ISX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_55866997 3.61 ENST00000360526.3
ENST00000361503.4
carboxylesterase 1
chr14_-_94789663 2.96 ENST00000557225.1
ENST00000341584.3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr4_-_185820602 2.91 ENST00000515864.1
ENST00000507183.1
long intergenic non-protein coding RNA 1093
chr19_+_4153598 2.67 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
cAMP responsive element binding protein 3-like 3
chr2_+_217524323 2.59 ENST00000456764.1
insulin-like growth factor binding protein 2, 36kDa
chr4_-_100242549 2.55 ENST00000305046.8
ENST00000394887.3
alcohol dehydrogenase 1B (class I), beta polypeptide
chr12_-_22063787 2.44 ENST00000544039.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr6_+_53948328 2.20 ENST00000370876.2
muscular LMNA-interacting protein
chr16_-_55867146 2.16 ENST00000422046.2
carboxylesterase 1
chr6_+_160542870 2.03 ENST00000324965.4
ENST00000457470.2
solute carrier family 22 (organic cation transporter), member 1
chr8_-_82395461 2.02 ENST00000256104.4
fatty acid binding protein 4, adipocyte
chr6_+_160542821 1.99 ENST00000366963.4
solute carrier family 22 (organic cation transporter), member 1
chr4_-_138453606 1.94 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
protocadherin 18
chr6_+_53948221 1.89 ENST00000460844.2
muscular LMNA-interacting protein
chr1_-_159915386 1.75 ENST00000361509.3
ENST00000368094.1
immunoglobulin superfamily, member 9
chr10_-_48416849 1.75 ENST00000249598.1
growth differentiation factor 2
chr12_+_16500037 1.74 ENST00000536371.1
ENST00000010404.2
microsomal glutathione S-transferase 1
chr4_+_155702496 1.68 ENST00000510397.1
RNA binding motif protein 46
chr12_-_103310987 1.66 ENST00000307000.2
phenylalanine hydroxylase
chr4_-_141348789 1.64 ENST00000414773.1
calmegin
chr7_-_88425025 1.59 ENST00000297203.2
chromosome 7 open reading frame 62
chr11_+_60383204 1.58 ENST00000412599.1
ENST00000320202.4
long intergenic non-protein coding RNA 301
chr3_-_149095652 1.57 ENST00000305366.3
transmembrane 4 L six family member 1
chr12_+_16500571 1.54 ENST00000543076.1
ENST00000396210.3
microsomal glutathione S-transferase 1
chr4_-_186733363 1.53 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
sorbin and SH3 domain containing 2
chr6_-_33860521 1.46 ENST00000525746.1
ENST00000531046.1
long intergenic non-protein coding RNA 1016
chrX_+_43515467 1.43 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr4_-_177190364 1.43 ENST00000296525.3
ankyrin repeat and SOCS box containing 5
chr12_+_16500599 1.41 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
microsomal glutathione S-transferase 1
chr4_-_138453559 1.41 ENST00000511115.1
protocadherin 18
chr22_-_28490123 1.39 ENST00000442232.1
tetratricopeptide repeat domain 28
chr4_-_141348763 1.37 ENST00000509477.1
calmegin
chr1_+_162336686 1.34 ENST00000420220.1
chromosome 1 open reading frame 226
chr6_+_25727046 1.32 ENST00000274764.2
histone cluster 1, H2ba
chr22_+_17956618 1.29 ENST00000262608.8
cat eye syndrome chromosome region, candidate 2
chr1_+_209602156 1.27 ENST00000429156.1
ENST00000366437.3
ENST00000603283.1
ENST00000431096.1
MIR205 host gene (non-protein coding)
chr7_-_100493482 1.25 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
acetylcholinesterase (Yt blood group)
chr17_-_40828969 1.23 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr4_-_141348999 1.23 ENST00000325617.5
calmegin
chr20_+_31805131 1.13 ENST00000375454.3
ENST00000375452.3
BPI fold containing family A, member 3
chr10_+_135160844 1.11 ENST00000423766.1
ENST00000458230.1
proline-rich acidic protein 1
chr4_-_48018680 1.10 ENST00000513178.1
cyclic nucleotide gated channel alpha 1
chr5_-_95297534 1.10 ENST00000513343.1
ENST00000431061.2
elongation factor, RNA polymerase II, 2
chr4_-_48018580 1.07 ENST00000514170.1
cyclic nucleotide gated channel alpha 1
chr17_-_40829026 1.05 ENST00000412503.1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr5_-_147286065 1.04 ENST00000318315.4
ENST00000515291.1
chromosome 5 open reading frame 46
chr15_-_58571445 1.04 ENST00000558231.1
aldehyde dehydrogenase 1 family, member A2
chr7_+_120628731 1.02 ENST00000310396.5
cadherin-like and PC-esterase domain containing 1
chr17_-_18266765 1.02 ENST00000354098.3
serine hydroxymethyltransferase 1 (soluble)
chrX_-_6453159 1.00 ENST00000381089.3
ENST00000398729.1
variable charge, X-linked 3A
chr5_-_95297678 0.96 ENST00000237853.4
elongation factor, RNA polymerase II, 2
chr4_-_69536346 0.96 ENST00000338206.5
UDP glucuronosyltransferase 2 family, polypeptide B15
chr6_-_85474219 0.95 ENST00000369663.5
T-box 18
chr17_+_50939459 0.94 ENST00000412360.1
Uncharacterized protein
chr9_-_4666421 0.94 ENST00000381895.5
spermatogenesis associated 6-like
chr20_-_50419055 0.93 ENST00000217086.4
spalt-like transcription factor 4
chrX_+_8433376 0.92 ENST00000440654.2
ENST00000381029.4
variable charge, X-linked 3B
chr4_-_171012844 0.92 ENST00000502392.1
aminoadipate aminotransferase
chr19_+_42811093 0.92 ENST00000595750.1
proline rich 19
chr7_-_143991230 0.91 ENST00000543357.1
Rho guanine nucleotide exchange factor (GEF) 35
chr3_+_28390637 0.91 ENST00000420223.1
ENST00000383768.2
zinc finger, CW type with PWWP domain 2
chr7_-_143892748 0.91 ENST00000378115.2
Rho guanine nucleotide exchange factor (GEF) 35
chr4_-_70080449 0.89 ENST00000446444.1
UDP glucuronosyltransferase 2 family, polypeptide B11
chrX_+_8432871 0.89 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
variable charge, X-linked 3B
chr4_+_108911036 0.89 ENST00000505878.1
hydroxyacyl-CoA dehydrogenase
chr21_+_35014783 0.88 ENST00000381291.4
ENST00000381285.4
ENST00000399367.3
ENST00000399352.1
ENST00000399355.2
ENST00000399349.1
intersectin 1 (SH3 domain protein)
chr1_-_209824643 0.88 ENST00000391911.1
ENST00000415782.1
laminin, beta 3
chr17_-_18266660 0.88 ENST00000582653.1
ENST00000352886.6
serine hydroxymethyltransferase 1 (soluble)
chr8_+_22132810 0.86 ENST00000356766.6
piwi-like RNA-mediated gene silencing 2
chr1_+_47533160 0.86 ENST00000334194.3
cytochrome P450, family 4, subfamily Z, polypeptide 1
chr3_+_51851612 0.85 ENST00000456080.1
IQ motif containing F3
chr3_+_140396881 0.85 ENST00000286349.3
tripartite motif containing 42
chr17_-_18266797 0.85 ENST00000316694.3
ENST00000539052.1
serine hydroxymethyltransferase 1 (soluble)
chr20_-_50418972 0.83 ENST00000395997.3
spalt-like transcription factor 4
chr9_+_136501478 0.82 ENST00000393056.2
ENST00000263611.2
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr2_-_198540751 0.81 ENST00000429081.1
raftlin family member 2
chr7_-_122339162 0.78 ENST00000340112.2
ring finger protein 133
chr20_-_50418947 0.77 ENST00000371539.3
spalt-like transcription factor 4
chr17_+_59489112 0.76 ENST00000335108.2
chromosome 17 open reading frame 82
chr6_+_78400375 0.76 ENST00000602452.2
meiosis-specific 4 homolog (S. cerevisiae)
chr1_-_36916066 0.75 ENST00000315643.9
organic solute carrier partner 1
chr1_-_153044083 0.74 ENST00000341611.2
small proline-rich protein 2B
chr21_+_35014706 0.74 ENST00000399353.1
ENST00000444491.1
ENST00000381318.3
intersectin 1 (SH3 domain protein)
chrX_+_130192318 0.74 ENST00000370922.1
Rho GTPase activating protein 36
chr6_-_49681235 0.74 ENST00000339139.4
cysteine-rich secretory protein 2
chr22_-_24303340 0.71 ENST00000404172.3
ENST00000290765.4
glutathione S-transferase theta 2B (gene/pseudogene)
chr2_-_227050079 0.70 ENST00000423838.1
AC068138.1
chr17_+_45286387 0.69 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
myosin, light chain 4, alkali; atrial, embryonic
chr6_-_25726781 0.68 ENST00000297012.3
histone cluster 1, H2aa
chr3_-_151034734 0.68 ENST00000260843.4
G protein-coupled receptor 87
chr1_-_36916011 0.68 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
organic solute carrier partner 1
chr2_+_87135076 0.68 ENST00000409776.2
RANBP2-like and GRIP domain containing 1
chr11_-_102709441 0.68 ENST00000434103.1
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_-_36915880 0.68 ENST00000445843.3
organic solute carrier partner 1
chr4_+_48018781 0.67 ENST00000295461.5
NIPA-like domain containing 1
chr10_-_104001231 0.67 ENST00000370002.3
paired-like homeodomain 3
chr11_+_100862811 0.67 ENST00000303130.2
transmembrane protein 133
chr3_+_147795932 0.65 ENST00000490465.1
RP11-639B1.1
chrX_-_8139308 0.62 ENST00000317103.4
variable charge, X-linked 2
chr3_-_48659193 0.59 ENST00000330862.3
transmembrane protein 89
chr1_+_151735431 0.58 ENST00000321531.5
ENST00000315067.8
ornithine decarboxylase antizyme 3
chr2_-_3521518 0.58 ENST00000382093.5
acireductone dioxygenase 1
chr16_+_3070313 0.58 ENST00000326577.4
tumor necrosis factor receptor superfamily, member 12A
chr10_+_99205959 0.57 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr5_+_53751445 0.56 ENST00000302005.1
heat shock 27kDa protein 3
chr22_+_24322322 0.56 ENST00000215780.5
ENST00000402588.3
glutathione S-transferase theta 2
chr11_+_77532233 0.56 ENST00000525409.1
adipogenesis associated, Mth938 domain containing
chr1_+_87595433 0.55 ENST00000469312.2
ENST00000490006.2
long intergenic non-protein coding RNA 1140
chr9_+_130159433 0.55 ENST00000451404.1
solute carrier family 2 (facilitated glucose transporter), member 8
chr8_+_22132847 0.54 ENST00000521356.1
piwi-like RNA-mediated gene silencing 2
chr16_+_3070356 0.51 ENST00000341627.5
ENST00000575124.1
ENST00000575836.1
tumor necrosis factor receptor superfamily, member 12A
chr17_-_18266818 0.51 ENST00000583780.1
serine hydroxymethyltransferase 1 (soluble)
chr1_+_40713573 0.50 ENST00000372766.3
transmembrane and coiled-coil domains 2
chr17_+_45286706 0.50 ENST00000393450.1
ENST00000572303.1
myosin, light chain 4, alkali; atrial, embryonic
chr22_-_32766972 0.50 ENST00000382084.4
ENST00000382086.2
RFPL3 antisense
chr20_-_17662705 0.48 ENST00000455029.2
ribosome binding protein 1
chrX_+_44703249 0.47 ENST00000339042.4
dual specificity phosphatase 21
chr8_+_92261516 0.47 ENST00000276609.3
ENST00000309536.2
solute carrier family 26 (anion exchanger), member 7
chr7_+_70597109 0.47 ENST00000333538.5
Williams-Beuren syndrome chromosome region 17
chr10_-_4285923 0.47 ENST00000418372.1
ENST00000608792.1
long intergenic non-protein coding RNA 702
chr2_-_198540719 0.46 ENST00000295049.4
raftlin family member 2
chr10_-_99447024 0.46 ENST00000370626.3
arginine vasopressin-induced 1
chr5_-_35938674 0.44 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
calcyphosine-like
chr8_+_7783859 0.44 ENST00000400120.3
zinc finger protein 705B
chr8_+_110552046 0.44 ENST00000529931.1
estrogen receptor binding site associated, antigen, 9
chr19_-_4717835 0.43 ENST00000599248.1
dipeptidyl-peptidase 9
chr3_+_97868170 0.43 ENST00000437310.1
olfactory receptor, family 5, subfamily H, member 14
chr16_-_31105870 0.43 ENST00000394971.3
vitamin K epoxide reductase complex, subunit 1
chr7_+_144052381 0.42 ENST00000498580.1
ENST00000056217.5
Rho guanine nucleotide exchange factor (GEF) 5
chr19_-_46285646 0.42 ENST00000458663.2
dystrophia myotonica-protein kinase
chr9_+_22646189 0.42 ENST00000436786.1
RP11-399D6.2
chr1_-_247876105 0.41 ENST00000302084.2
olfactory receptor, family 6, subfamily F, member 1
chr3_-_180397256 0.41 ENST00000442201.2
coiled-coil domain containing 39
chr2_-_8715616 0.40 ENST00000418358.1
AC011747.3
chrY_+_14813160 0.40 ENST00000338981.3
ubiquitin specific peptidase 9, Y-linked
chr14_+_32798462 0.40 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr14_+_39944025 0.40 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
chr6_-_135271260 0.40 ENST00000265605.2
aldehyde dehydrogenase 8 family, member A1
chr16_-_31106211 0.40 ENST00000532364.1
ENST00000529564.1
ENST00000319788.7
ENST00000354895.4
ENST00000394975.2
Uncharacterized protein
vitamin K epoxide reductase complex, subunit 1
chr11_+_77532155 0.39 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
adipogenesis associated, Mth938 domain containing
chr10_-_4285835 0.39 ENST00000454470.1
long intergenic non-protein coding RNA 702
chr6_-_135271219 0.38 ENST00000367847.2
ENST00000367845.2
aldehyde dehydrogenase 8 family, member A1
chr6_-_31125850 0.37 ENST00000507751.1
ENST00000448162.2
ENST00000502557.1
ENST00000503420.1
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.1
ENST00000396263.2
ENST00000508683.1
ENST00000428174.1
ENST00000448141.2
ENST00000507829.1
ENST00000455279.2
ENST00000376266.5
coiled-coil alpha-helical rod protein 1
chr2_-_183387064 0.37 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
phosphodiesterase 1A, calmodulin-dependent
chr19_-_46285736 0.37 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
dystrophia myotonica-protein kinase
chr15_+_55700741 0.37 ENST00000569691.1
chromosome 15 open reading frame 65
chr7_+_130020932 0.37 ENST00000484324.1
carboxypeptidase A1 (pancreatic)
chr17_-_38821373 0.37 ENST00000394052.3
keratin 222
chr6_+_39760129 0.36 ENST00000274867.4
dishevelled associated activator of morphogenesis 2
chr16_-_31106048 0.36 ENST00000300851.6
vitamin K epoxide reductase complex, subunit 1
chr3_-_160823158 0.36 ENST00000392779.2
ENST00000392780.1
ENST00000494173.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr11_-_63381925 0.36 ENST00000415826.1
phospholipase A2, group XVI
chr17_-_7307358 0.35 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr3_+_186288454 0.35 ENST00000265028.3
DnaJ (Hsp40) homolog, subfamily B, member 11
chr8_+_110551925 0.34 ENST00000395785.2
estrogen receptor binding site associated, antigen, 9
chr14_-_53258314 0.33 ENST00000216410.3
ENST00000557604.1
glucosamine-phosphate N-acetyltransferase 1
chr3_-_129147432 0.33 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EF-hand calcium binding domain 12
chr13_+_111748183 0.33 ENST00000422994.1
long intergenic non-protein coding RNA 368
chr3_-_160823040 0.33 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr11_-_95522639 0.32 ENST00000536839.1
family with sequence similarity 76, member B
chr13_+_73632897 0.32 ENST00000377687.4
Kruppel-like factor 5 (intestinal)
chr2_+_242089833 0.32 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
protein phosphatase 1, regulatory subunit 7
chr10_+_99205894 0.32 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
zinc finger, DHHC-type containing 16
chr11_-_63381823 0.32 ENST00000323646.5
phospholipase A2, group XVI
chr12_+_104680659 0.31 ENST00000526691.1
ENST00000531691.1
ENST00000388854.3
ENST00000354940.6
ENST00000526390.1
ENST00000531689.1
thioredoxin reductase 1
chr22_-_24316648 0.31 ENST00000403754.3
ENST00000430101.2
ENST00000398344.4
D-dopachrome tautomerase
chr12_+_52695617 0.30 ENST00000293525.5
keratin 86
chrX_-_139587225 0.30 ENST00000370536.2
SRY (sex determining region Y)-box 3
chr22_-_32767017 0.29 ENST00000400234.1
RFPL3 antisense
chr11_-_118023490 0.29 ENST00000324727.4
sodium channel, voltage-gated, type IV, beta subunit
chr3_+_148709128 0.29 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
glycogenin 1
chr11_-_111741994 0.28 ENST00000398006.2
ALG9, alpha-1,2-mannosyltransferase
chr11_-_62414070 0.27 ENST00000540933.1
ENST00000346178.4
ENST00000356638.3
ENST00000534779.1
ENST00000525994.1
glucosidase, alpha; neutral AB
chr21_+_35014829 0.27 ENST00000451686.1
intersectin 1 (SH3 domain protein)
chr1_-_161208013 0.27 ENST00000515452.1
ENST00000367983.4
nuclear receptor subfamily 1, group I, member 3
chr12_-_50790267 0.26 ENST00000327337.5
ENST00000543111.1
family with sequence similarity 186, member A
chr11_-_95523500 0.26 ENST00000540054.1
family with sequence similarity 76, member B
chr20_+_44441271 0.26 ENST00000335046.3
ENST00000243893.6
ubiquitin-conjugating enzyme E2C
chr1_+_23345943 0.26 ENST00000400181.4
ENST00000542151.1
lysine (K)-specific demethylase 1A
chr12_-_120966943 0.26 ENST00000552443.1
ENST00000547736.1
ENST00000445328.2
ENST00000547943.1
ENST00000288532.6
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr6_+_34204642 0.26 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr12_+_48499252 0.25 ENST00000549003.1
ENST00000550924.1
phosphofructokinase, muscle
chr11_+_57480046 0.25 ENST00000378312.4
ENST00000278422.4
thioredoxin-related transmembrane protein 2
chr15_+_80351910 0.25 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chr3_-_105587879 0.24 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr6_+_36164487 0.24 ENST00000357641.6
bromodomain and PHD finger containing, 3
chrX_+_19362011 0.24 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
pyruvate dehydrogenase (lipoamide) alpha 1
chr11_-_118023594 0.24 ENST00000529878.1
sodium channel, voltage-gated, type IV, beta subunit
chr1_+_23345930 0.24 ENST00000356634.3
lysine (K)-specific demethylase 1A
chr6_-_30080863 0.24 ENST00000540829.1
tripartite motif containing 31
chr9_+_34646624 0.24 ENST00000450095.2
ENST00000556278.1
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr17_-_27418537 0.23 ENST00000408971.2
TGFB1-induced anti-apoptotic factor 1
chr1_-_197115818 0.23 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr6_-_138833630 0.23 ENST00000533765.1
NHS-like 1
chr9_+_104296122 0.23 ENST00000389120.3
ring finger protein 20, E3 ubiquitin protein ligase
chr14_+_52313833 0.23 ENST00000553560.1
guanine nucleotide binding protein (G protein), gamma 2
chr2_+_86947296 0.23 ENST00000283632.4
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr11_-_13517565 0.22 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr4_-_69434245 0.22 ENST00000317746.2
UDP glucuronosyltransferase 2 family, polypeptide B17
chr5_+_140557371 0.22 ENST00000239444.2
protocadherin beta 8

Network of associatons between targets according to the STRING database.

First level regulatory network of ISX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
1.4 5.8 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.8 3.2 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.6 4.0 GO:0048241 epinephrine transport(GO:0048241)
0.4 1.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.3 1.0 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.3 1.3 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.2 0.4 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.2 1.8 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 0.9 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) L-kynurenine metabolic process(GO:0097052)
0.2 2.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 2.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 2.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.7 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 1.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 4.6 GO:0010226 response to lithium ion(GO:0010226)
0.1 0.8 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 2.6 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.6 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 1.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.4 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.1 1.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 1.3 GO:0032596 protein transport into membrane raft(GO:0032596)
0.1 0.2 GO:0051795 positive regulation of catagen(GO:0051795)
0.1 1.7 GO:0006558 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 4.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.2 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.5 GO:0046098 guanine metabolic process(GO:0046098)
0.1 0.7 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 2.3 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.1 0.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.8 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1 2.2 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 0.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 1.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.7 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 1.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 1.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.3 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.7 GO:0015693 magnesium ion transport(GO:0015693)
0.0 2.4 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0033184 positive regulation of histone ubiquitination(GO:0033184) regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.3 GO:0044550 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438) secondary metabolite biosynthetic process(GO:0044550)
0.0 0.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.5 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 1.9 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.7 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.5 GO:0019532 oxalate transport(GO:0019532)
0.0 0.5 GO:0086027 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.9 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 1.2 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.7 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.7 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.8 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.5 GO:0007141 male meiosis I(GO:0007141)
0.0 2.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.0 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.5 GO:0090662 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:1990923 PET complex(GO:1990923)
0.3 2.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 2.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.9 GO:0005610 laminin-5 complex(GO:0005610)
0.1 1.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.1 0.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 1.0 GO:0031010 ISWI-type complex(GO:0031010)
0.1 0.2 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 5.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.8 GO:0000800 lateral element(GO:0000800)
0.0 0.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 2.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 3.6 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 6.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 1.2 GO:0031672 A band(GO:0031672)
0.0 0.0 GO:0072589 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
1.0 4.0 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.6 2.4 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.5 3.2 GO:0070905 serine binding(GO:0070905)
0.3 0.9 GO:0047536 2-aminoadipate transaminase activity(GO:0047536)
0.3 2.6 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 1.4 GO:0034584 piRNA binding(GO:0034584)
0.3 1.7 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.3 1.3 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.2 1.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.2 1.2 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.2 4.7 GO:0043295 glutathione binding(GO:0043295)
0.2 0.6 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.2 2.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.7 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.2 0.5 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.2 1.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 2.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.7 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 1.8 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.8 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 4.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.3 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
0.1 2.4 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.3 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.1 0.3 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.0 1.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0004882 androgen receptor activity(GO:0004882)
0.0 1.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.9 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.9 GO:0070330 aromatase activity(GO:0070330)
0.0 1.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 1.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.7 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.8 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.4 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 1.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.9 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.6 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.7 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 3.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 2.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 4.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 3.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle