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Illumina Body Map 2
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Results for TFAP2E
Z-value: 0.62
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Transcription factors associated with TFAP2E
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2E | hg19_v2_chr1_+_36038971_36038971 | -0.24 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_115152651 Show fit | 3.21 |
ENST00000250535.4
|
cysteine dioxygenase type 1 |
|
| chr11_+_116700600 Show fit | 2.78 |
ENST00000227667.3
|
apolipoprotein C-III |
|
| chr11_+_116700614 Show fit | 2.75 |
ENST00000375345.1
|
apolipoprotein C-III |
|
| chr14_+_24837226 Show fit | 2.43 |
ENST00000554050.1
ENST00000554903.1 ENST00000554779.1 ENST00000250373.4 ENST00000553708.1 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
|
| chr11_-_61062762 Show fit | 1.75 |
ENST00000335613.5
|
von Willebrand factor C and EGF domains |
|
| chr12_+_53443963 Show fit | 1.62 |
ENST00000546602.1
ENST00000552570.1 ENST00000549700.1 |
tensin like C1 domain containing phosphatase (tensin 2) |
|
| chr3_+_52813932 Show fit | 1.52 |
ENST00000537050.1
|
inter-alpha-trypsin inhibitor heavy chain 1 |
|
| chr9_+_136501478 Show fit | 1.39 |
ENST00000393056.2
ENST00000263611.2 |
dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
|
| chr3_+_50192833 Show fit | 1.38 |
ENST00000426511.1
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
|
| chr12_-_15942503 Show fit | 1.33 |
ENST00000281172.5
|
epidermal growth factor receptor pathway substrate 8 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2E
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.5 | GO:0060621 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.6 | 3.2 | GO:0042412 | taurine biosynthetic process(GO:0042412) |
| 0.0 | 3.0 | GO:0002209 | behavioral fear response(GO:0001662) behavioral defense response(GO:0002209) |
| 0.5 | 2.4 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.3 | 2.3 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.1 | 2.1 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 1.9 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 1.7 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 1.5 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.2 | 1.4 | GO:0042421 | norepinephrine biosynthetic process(GO:0042421) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.5 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 3.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 2.1 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 1.7 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 1.6 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 1.4 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.0 | 1.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.3 | GO:0042599 | lamellar body(GO:0042599) |
| 0.2 | 1.0 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.5 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 3.8 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 3.2 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 2.4 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 2.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 2.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 1.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.2 | 1.4 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.1 | 1.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.9 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.3 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 3.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.6 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.0 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |