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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: ATF4.p2

Z-value: 2.843

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_-_123380608	91.173
chr5_-_133561745	70.025		PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_+_16187306	69.868		TPM4	tropomyosin 4
chr8_-_17104266	68.307	NM_013354 NM_054026	CNOT7	CCR4-NOT transcription complex, subunit 7
chr6_+_47445440	62.788	NM_012120	CD2AP	CD2-associated protein
chr11_+_4116059	61.361		RRM1	ribonucleotide reductase M1
chr22_+_24236579	60.840		MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr22_+_24236575	60.029
chr22_+_24236569	59.882		MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr19_+_16187266	59.790		TPM4	tropomyosin 4
chr19_-_55918980	57.148		UBE2S	ubiquitin-conjugating enzyme E2S
chr22_+_24236586	57.041		MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr22_+_24236556	54.700	NM_002415	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr1_+_26496382	54.658	NM_015871	ZNF593	zinc finger protein 593
chr19_+_16187315	52.173		TPM4	tropomyosin 4
chr8_+_26149004	50.614	NM_002717	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr8_+_26149043	49.522		PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr11_+_4115923	48.082	NM_001033	RRM1	ribonucleotide reductase M1
chr22_+_24236595	46.073		MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr5_-_133561551	45.987		PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_-_47617008	44.738	NM_015168	ZC3H4	zinc finger CCCH-type containing 4
chr8_-_17104103	44.223		CNOT7	CCR4-NOT transcription complex, subunit 7
chr11_+_4116077	43.109		RRM1	ribonucleotide reductase M1
chr2_-_32236104	42.375		MEMO1	mediator of cell motility 1
chr1_-_70671263	40.860	NM_017768	LRRC40	leucine rich repeat containing 40
chr3_+_38206968	40.799	NM_005109	OXSR1	oxidative-stress responsive 1
chr3_-_49066760	39.963		IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2
chr15_-_91537724	39.708	NM_003981 NM_199413 NM_199414	PRC1	protein regulator of cytokinesis 1
chr3_-_49066858	39.086	NM_000884	IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2
chr7_+_56019552	38.650	NM_015969	MRPS17	mitochondrial ribosomal protein S17
chr1_+_52082755	38.366		OSBPL9	oxysterol binding protein-like 9
chr6_-_31774579	37.749		LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_-_245025958	37.127		HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr2_-_240964717	37.029		NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr12_-_6862131	36.219		MLF2	myeloid leukemia factor 2
chr18_+_20513277	35.628	NM_002894	RBBP8	retinoblastoma binding protein 8
chr3_-_49066813	35.420		IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2
chr6_-_53213586	35.240		ELOVL5	ELOVL fatty acid elongase 5
chr4_-_122744978	34.562	NM_001237	CCNA2	cyclin A2
chr4_-_104119475	33.995	NM_001813	CENPE	centromere protein E, 312kDa
chr4_-_122744782	33.863		CCNA2	cyclin A2
chr11_+_102217947	33.742	NM_001166	BIRC2	baculoviral IAP repeat containing 2
chr8_+_26149080	33.539		PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr7_+_140396463	33.253	NM_004546	NDUFB2	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr2_+_113403433	33.249	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr19_+_50180408	33.118	NM_001207042 NM_001536 NM_198318	PRMT1	protein arginine methyltransferase 1
chr1_-_115124211	33.049	NM_005872	BCAS2	breast carcinoma amplified sequence 2
chr19_+_50180492	32.730		PRMT1	protein arginine methyltransferase 1
chr12_+_69979268	32.466		CCT2	chaperonin containing TCP1, subunit 2 (beta)
chr15_-_23034307	32.442		NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2
chr6_-_31774725	32.432	NM_021177	LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_+_100273776	31.559		GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2
chr19_-_40337018	31.441	NM_001436	FBL	fibrillarin
chr7_+_107531585	30.961	NM_000108	DLD	dihydrolipoamide dehydrogenase
chr11_-_67188614	30.567		PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme
chr10_-_75006963	30.517	NM_015190	DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9
chr1_-_70671160	30.509		LRRC40	leucine rich repeat containing 40
chr14_+_105219466	30.091	NM_006427 NM_021709	SIVA1	SIVA1, apoptosis-inducing factor
chr19_-_40336944	29.885		FBL	fibrillarin
chr12_+_69979202	29.871	NM_006431	CCT2	chaperonin containing TCP1, subunit 2 (beta)
chr2_-_240964807	29.633	NM_004544	NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr7_+_107531618	29.402		DLD	dihydrolipoamide dehydrogenase
chr7_+_107531616	29.121		DLD	dihydrolipoamide dehydrogenase
chr3_-_52312655	28.894	NM_025222	WDR82	WD repeat domain 82
chr11_-_61584451	28.795	NM_013402	FADS1	fatty acid desaturase 1
chr5_+_10353980	28.303
chr5_-_32174385	27.892		GOLPH3	golgi phosphoprotein 3 (coat-protein)
chr14_+_100705101	27.868	NM_003403	YY1	YY1 transcription factor
chr20_+_19915716	27.529		RIN2	Ras and Rab interactor 2
chr2_-_62115714	27.138		CCT4	chaperonin containing TCP1, subunit 4 (delta)
chr7_+_26240830	27.027	NM_007276	CBX3	chromobox homolog 3
chr5_+_138211084	26.968		CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa
chr12_+_69979447	26.726	NM_001198842	CCT2	chaperonin containing TCP1, subunit 2 (beta)
chr22_+_39898365	26.533		SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like
chr1_+_203830723	26.412		SNRPE	small nuclear ribonucleoprotein polypeptide E
chr2_-_62115726	26.363		CCT4	chaperonin containing TCP1, subunit 4 (delta)
chr1_+_110527327	26.331	NM_001242673 NM_006621	AHCYL1	adenosylhomocysteinase-like 1
chr11_+_108535773	26.256	NM_004398	DDX10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr12_+_69004684	26.218		RAP1B	RAP1B, member of RAS oncogene family
chr17_+_33914278	25.873	NM_001030006 NM_001282	AP2B1	adaptor-related protein complex 2, beta 1 subunit
chr9_-_95055913	25.711		IARS	isoleucyl-tRNA synthetase
chr19_+_16187047	25.653	NM_003290	TPM4	tropomyosin 4
chr5_-_32174397	25.510	NM_022130	GOLPH3	golgi phosphoprotein 3 (coat-protein)
chr5_-_32174355	25.454		GOLPH3	golgi phosphoprotein 3 (coat-protein)
chr19_-_40336997	25.067		FBL	fibrillarin
chr19_+_36036448	24.828	NM_001242597 NM_001242598 NM_032635	TMEM147	transmembrane protein 147
chr16_+_81040847	24.532		CENPN	centromere protein N
chr11_-_6633400	24.252		TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr1_+_203830732	24.249	NM_003094	SNRPE	small nuclear ribonucleoprotein polypeptide E
chr21_-_44527603	24.127		U2AF1	U2 small nuclear RNA auxiliary factor 1
chr12_+_69004710	23.992		RAP1B	RAP1B, member of RAS oncogene family
chr1_+_44440623	23.812		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr14_+_55518398	23.687		MAPK1IP1L	mitogen-activated protein kinase 1 interacting protein 1-like
chr12_+_132629014	23.647		NOC4L	nucleolar complex associated 4 homolog (S. cerevisiae)
chr12_+_104359557	23.580	NM_003211	TDG	thymine-DNA glycosylase
chr9_-_95055966	23.475	NM_013417	IARS	isoleucyl-tRNA synthetase
chr11_+_18416111	23.300		LDHA	lactate dehydrogenase A
chr1_-_229644077	23.281	NM_018230	NUP133	nucleoporin 133kDa
chr18_+_57567191	23.119	NM_021127	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
chr1_+_44440595	23.056	NM_001039457 NM_004047	ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr7_-_26240364	23.046		HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1
chr12_+_56552141	23.044		MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle
chr11_+_18416106	23.027		LDHA	lactate dehydrogenase A
chr5_+_177631533	22.584		HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B
chr3_+_170075521	22.527		SKIL	SKI-like oncogene
chr2_-_32235603	22.506	NM_001137602 NM_015955	MEMO1	mediator of cell motility 1
chr22_-_36925212	22.425		EIF3D	eukaryotic translation initiation factor 3, subunit D
chr1_+_44440642	22.358		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr2_-_32235722	22.335		MEMO1	mediator of cell motility 1
chr14_+_55518313	22.313	NM_144578	MAPK1IP1L	mitogen-activated protein kinase 1 interacting protein 1-like
chr19_+_572568	22.174		BSG	basigin (Ok blood group)
chr9_-_95055986	22.136		IARS	isoleucyl-tRNA synthetase
chr7_+_127228405	22.128	NM_001662	ARF5	ADP-ribosylation factor 5
chr1_-_16482426	22.087	NM_004431	EPHA2	EPH receptor A2
chr7_+_5632435	22.038	NM_003088	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr19_+_10362912	22.031		MRPL4	mitochondrial ribosomal protein L4
chr3_-_113465101	21.963	NM_025146	NAA50	N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_-_62115744	21.878	NM_006430	CCT4	chaperonin containing TCP1, subunit 4 (delta)
chr17_-_20946088	21.786	NM_015276	USP22	ubiquitin specific peptidase 22
chr20_-_60718440	21.597	NM_002792	PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr22_-_36925270	21.573	NM_003753	EIF3D	eukaryotic translation initiation factor 3, subunit D
chr11_-_3818971	21.550	NM_005387 NM_016320 NM_139131 NM_139132	NUP98	nucleoporin 98kDa
chr1_-_229643996	21.526		NUP133	nucleoporin 133kDa
chr16_-_46655303	21.464	NM_024745	SHCBP1	SHC SH2-domain binding protein 1
chr14_+_55518372	21.392		MAPK1IP1L	mitogen-activated protein kinase 1 interacting protein 1-like
chr5_-_32174327	21.362		GOLPH3	golgi phosphoprotein 3 (coat-protein)
chr22_+_39898248	21.307	NM_019008	SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like
chr7_+_44646220	21.278		OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_-_26240320	21.253		HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_242255365	21.174		SEPT2	septin 2
chr7_-_105925329	21.146		NAMPT	nicotinamide phosphoribosyltransferase
chr11_+_95523608	21.145	NM_001243776 NM_001243777 NM_014679	CEP57	centrosomal protein 57kDa
chr7_-_26240366	21.110	NM_002137 NM_031243	HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1
chr18_+_158586	21.064		USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr22_-_36925138	21.042		EIF3D	eukaryotic translation initiation factor 3, subunit D
chr19_-_14529853	20.974		DDX39A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr14_-_103523619	20.968	NM_006035	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)
chr2_-_62115641	20.879		CCT4	chaperonin containing TCP1, subunit 4 (delta)
chr1_+_70671331	20.795	NM_001190987 NM_004768	SRSF11	serine/arginine-rich splicing factor 11
chr8_+_98788014	20.705		LAPTM4B	lysosomal protein transmembrane 4 beta
chr6_-_3157696	20.662	NM_001069	TUBB2A	tubulin, beta 2A class IIa
chr3_+_127317274	20.628		MCM2	minichromosome maintenance complex component 2
chr19_-_8070468	20.282	NM_001419	ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
chr17_+_80674579	20.278	NM_024619	FN3KRP	fructosamine 3 kinase related protein
chr17_+_15902693	20.088	NM_017775	TTC19	tetratricopeptide repeat domain 19
chr3_+_38207247	20.074		OXSR1	oxidative-stress responsive 1
chr11_-_28129646	19.957		KIF18A	kinesin family member 18A
chr1_+_203830763	19.906		SNRPE	small nuclear ribonucleoprotein polypeptide E
chr19_+_10362886	19.880		MRPL4	mitochondrial ribosomal protein L4
chr2_-_10588451	19.866	NM_002539	ODC1	ornithine decarboxylase 1
chr19_-_14530129	19.785		DDX39A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr3_-_133380626	19.627	NM_007027	TOPBP1	topoisomerase (DNA) II binding protein 1
chr1_-_33283632	19.598	NM_003680	YARS	tyrosyl-tRNA synthetase
chr12_+_54378929	19.564	NM_017409	HOXC10	homeobox C10
chr5_-_133561805	19.454	NM_002715	PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme
chrX_+_153672490	19.441		FAM50A	family with sequence similarity 50, member A
chr17_-_56084611	19.433		SRSF1	serine/arginine-rich splicing factor 1
chr19_-_55919324	19.302	NM_014501	UBE2S	ubiquitin-conjugating enzyme E2S
chr22_+_38597938	19.301	NM_001161572 NM_001161574 NM_012323	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_-_156877882	19.296		CCNL1	cyclin L1
chr5_-_133304274	19.267	NM_020199	C5orf15	chromosome 5 open reading frame 15
chr1_-_31769599	19.227	NM_004814	SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)
chr4_+_170541690	19.190		CLCN3	chloride channel 3
chr11_+_118230348	19.095		UBE4A	ubiquitination factor E4A
chr2_-_70520780	18.996		SNRPG	small nuclear ribonucleoprotein polypeptide G
chr18_+_158480	18.987	NM_001037334 NM_005151	USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr19_+_1941157	18.973	NM_001319	CSNK1G2	casein kinase 1, gamma 2
chr1_-_32110464	18.942		PEF1	penta-EF-hand domain containing 1
chr19_+_13263890	18.822		IER2	immediate early response 2
chr16_+_28722977	18.807		EIF3C	eukaryotic translation initiation factor 3, subunit C
chr19_+_36630999	18.769		CAPNS1	calpain, small subunit 1
chr16_-_46655262	18.715		SHCBP1	SHC SH2-domain binding protein 1
chr19_+_572575	18.680		BSG	basigin (Ok blood group)
chrX_+_153672449	18.624	NM_004699	FAM50A	family with sequence similarity 50, member A
chr11_-_6633428	18.508	NM_006284	TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chrX_+_67718868	18.463		YIPF6	Yip1 domain family, member 6
chr19_+_572403	18.431	NM_001728 NM_198589	BSG	basigin (Ok blood group)
chr9_-_127952037	18.424	NM_001123355 NM_001123369 NM_002721	PPP6C	protein phosphatase 6, catalytic subunit
chr5_+_177631534	18.386		HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B
chr17_+_8152594	18.383	NM_012393	PFAS	phosphoribosylformylglycinamidine synthase
chr22_-_36925175	18.339		EIF3D	eukaryotic translation initiation factor 3, subunit D
chr14_+_100705279	18.291		YY1	YY1 transcription factor
chr1_+_110527432	18.290		AHCYL1	adenosylhomocysteinase-like 1
chr10_+_85899184	18.210	NM_014394	GHITM	growth hormone inducible transmembrane protein
chr19_-_59066477	18.194	NM_014453	CHMP2A	charged multivesicular body protein 2A
chr8_-_146017774	18.178		RPL8	ribosomal protein L8
chr3_+_128445026	18.153		RAB7A	RAB7A, member RAS oncogene family
chr9_-_111696173	18.075		IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr22_+_32340435	18.026	NM_003405	YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr4_+_17812524	17.997	NM_022346	NCAPG	non-SMC condensin I complex, subunit G
chr11_-_6633178	17.993		TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr5_-_32174242	17.912		GOLPH3	golgi phosphoprotein 3 (coat-protein)
chr18_+_72163335	17.830	NM_018235	CNDP2	CNDP dipeptidase 2 (metallopeptidase M20 family)
chr16_-_3767449	17.771	NM_016292	TRAP1	TNF receptor-associated protein 1
chr20_+_361675	17.751		TRIB3	tribbles homolog 3 (Drosophila)
chr1_-_53704121	17.689	NM_002370	MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)
chr6_-_42713837	17.649	NM_003192	TBCC	tubulin folding cofactor C
chr19_+_36631001	17.550		CAPNS1	calpain, small subunit 1
chr10_-_33247131	17.459		ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr1_+_44440673	17.396		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.61	3.28e-29	GO:0044237	cellular metabolic process
1.76	8.89e-26	GO:0044260	cellular macromolecule metabolic process
1.49	1.08e-23	GO:0008152	metabolic process
1.54	2.99e-23	GO:0044238	primary metabolic process
1.63	1.60e-21	GO:0043170	macromolecule metabolic process
1.80	4.62e-19	GO:0006807	nitrogen compound metabolic process
1.82	6.38e-19	GO:0034641	cellular nitrogen compound metabolic process
1.90	1.13e-18	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.87	1.62e-15	GO:0044267	cellular protein metabolic process
1.91	1.71e-14	GO:0090304	nucleic acid metabolic process
1.22	1.39e-13	GO:0009987	cellular process
1.69	2.55e-12	GO:0019538	protein metabolic process
5.19	8.59e-10	GO:0050657	nucleic acid transport
5.19	8.59e-10	GO:0050658	RNA transport
5.19	8.59e-10	GO:0051236	establishment of RNA localization
2.39	1.25e-09	GO:0046907	intracellular transport
5.02	2.08e-09	GO:0006403	RNA localization
1.83	2.93e-09	GO:0010467	gene expression
1.55	3.55e-09	GO:0071840	cellular component organization or biogenesis
1.63	1.54e-08	GO:0071841	cellular component organization or biogenesis at cellular level
2.27	2.01e-08	GO:0033554	cellular response to stress
5.06	2.79e-08	GO:0051028	mRNA transport
4.47	4.12e-08	GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport
1.80	5.00e-08	GO:0016070	RNA metabolic process
2.44	5.20e-08	GO:0006396	RNA processing
1.52	1.01e-07	GO:0016043	cellular component organization
1.64	1.31e-07	GO:0044249	cellular biosynthetic process
1.59	3.87e-07	GO:0071842	cellular component organization at cellular level
1.77	6.16e-07	GO:0034645	cellular macromolecule biosynthetic process
1.95	7.99e-07	GO:0044248	cellular catabolic process
1.59	1.08e-06	GO:0009058	biosynthetic process
1.75	1.30e-06	GO:0009059	macromolecule biosynthetic process
2.37	2.88e-06	GO:0000278	mitotic cell cycle
1.97	4.70e-06	GO:0007049	cell cycle
1.92	5.01e-06	GO:0051649	establishment of localization in cell
2.22	5.39e-06	GO:0022403	cell cycle phase
2.89	8.19e-06	GO:0006412	translation
1.72	1.37e-05	GO:0006996	organelle organization
1.82	1.75e-05	GO:0051641	cellular localization
2.06	1.85e-05	GO:0022402	cell cycle process
2.35	1.93e-05	GO:0044265	cellular macromolecule catabolic process
3.47	3.20e-05	GO:0006913	nucleocytoplasmic transport
3.43	4.13e-05	GO:0051169	nuclear transport
4.80	4.95e-05	GO:0051168	nuclear export
1.77	5.40e-05	GO:0033036	macromolecule localization
2.69	9.62e-05	GO:0019941	modification-dependent protein catabolic process
2.67	1.14e-04	GO:0043632	modification-dependent macromolecule catabolic process
1.52	1.24e-04	GO:0048522	positive regulation of cellular process
3.17	1.30e-04	GO:0000375	RNA splicing, via transesterification reactions
1.95	1.48e-04	GO:0045184	establishment of protein localization
1.95	1.60e-04	GO:0015031	protein transport
2.62	1.90e-04	GO:0051603	proteolysis involved in cellular protein catabolic process
2.69	2.08e-04	GO:0008380	RNA splicing
2.40	2.23e-04	GO:0072521	purine-containing compound metabolic process
1.69	2.67e-04	GO:0009056	catabolic process
7.28	2.72e-04	GO:0034976	response to endoplasmic reticulum stress
5.12	2.88e-04	GO:0006986	response to unfolded protein
2.57	3.12e-04	GO:0044257	cellular protein catabolic process
3.09	3.83e-04	GO:0006457	protein folding
2.11	4.09e-04	GO:0009057	macromolecule catabolic process
2.59	5.29e-04	GO:0006511	ubiquitin-dependent protein catabolic process
1.75	6.95e-04	GO:0044085	cellular component biogenesis
1.49	7.14e-04	GO:0006950	response to stress
2.04	7.49e-04	GO:0046483	heterocycle metabolic process
3.02	9.92e-04	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
3.02	9.92e-04	GO:0000398	nuclear mRNA splicing, via spliceosome
1.77	1.39e-03	GO:0008104	protein localization
2.48	1.49e-03	GO:0009259	ribonucleotide metabolic process
1.44	1.51e-03	GO:0048518	positive regulation of biological process
2.40	1.68e-03	GO:0030163	protein catabolic process
2.50	1.80e-03	GO:0009150	purine ribonucleotide metabolic process
2.30	1.81e-03	GO:0016032	viral reproduction
2.11	2.64e-03	GO:0016071	mRNA metabolic process
4.64	2.75e-03	GO:0006405	RNA export from nucleus
2.32	2.76e-03	GO:0006397	mRNA processing
1.52	3.23e-03	GO:0043412	macromolecule modification
5.72	4.12e-03	GO:0006369	termination of RNA polymerase II transcription
2.49	4.22e-03	GO:0051329	interphase of mitotic cell cycle
2.57	4.48e-03	GO:0034660	ncRNA metabolic process
2.09	5.51e-03	GO:0006974	response to DNA damage stimulus
1.53	5.64e-03	GO:0006464	protein modification process
2.45	6.16e-03	GO:0051325	interphase
2.25	7.60e-03	GO:0006163	purine nucleotide metabolic process
2.02	7.99e-03	GO:0055086	nucleobase, nucleoside and nucleotide metabolic process
2.81	1.03e-02	GO:0022613	ribonucleoprotein complex biogenesis
6.56	1.03e-02	GO:0006984	ER-nucleus signaling pathway
1.66	1.09e-02	GO:0031325	positive regulation of cellular metabolic process
1.69	1.31e-02	GO:0010941	regulation of cell death
1.79	1.36e-02	GO:0043933	macromolecular complex subunit organization
1.70	1.41e-02	GO:0043067	regulation of programmed cell death
2.14	1.49e-02	GO:0000279	M phase
1.96	1.53e-02	GO:0006259	DNA metabolic process
2.53	1.89e-02	GO:0072523	purine-containing compound catabolic process
1.69	1.96e-02	GO:0042981	regulation of apoptosis
2.27	2.18e-02	GO:0006281	DNA repair
2.60	2.51e-02	GO:0009154	purine ribonucleotide catabolic process
2.66	2.53e-02	GO:0071843	cellular component biogenesis at cellular level
3.20	2.53e-02	GO:0051789	response to protein stimulus
8.05	2.59e-02	GO:0030968	endoplasmic reticulum unfolded protein response
8.05	2.59e-02	GO:0034620	cellular response to unfolded protein
1.60	2.84e-02	GO:0009893	positive regulation of metabolic process
2.58	2.96e-02	GO:0009261	ribonucleotide catabolic process
2.33	3.15e-02	GO:0000087	M phase of mitotic cell cycle
2.50	3.38e-02	GO:0006195	purine nucleotide catabolic process
1.91	3.45e-02	GO:0071822	protein complex subunit organization
1.66	3.60e-02	GO:0022607	cellular component assembly
1.48	3.72e-02	GO:0044281	small molecule metabolic process
1.99	3.76e-02	GO:0006753	nucleoside phosphate metabolic process
1.99	3.76e-02	GO:0009117	nucleotide metabolic process
1.73	4.00e-02	GO:0008219	cell death
2.42	4.38e-02	GO:0009166	nucleotide catabolic process
2.52	4.42e-02	GO:0051129	negative regulation of cellular component organization
2.00	4.48e-02	GO:0034621	cellular macromolecular complex subunit organization
2.57	4.54e-02	GO:0000075	cell cycle checkpoint
1.72	4.67e-02	GO:0016265	death
2.36	4.76e-02	GO:0010608	posttranscriptional regulation of gene expression
2.95	4.87e-02	GO:0031396	regulation of protein ubiquitination
4.16	4.95e-02	GO:0031124	mRNA 3'-end processing

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.43	1.28e-26	GO:0005737	cytoplasm
1.28	2.30e-26	GO:0044424	intracellular part
1.25	3.16e-23	GO:0005622	intracellular
1.56	5.93e-22	GO:0044422	organelle part
1.56	6.83e-22	GO:0044446	intracellular organelle part
1.35	1.52e-20	GO:0043231	intracellular membrane-bounded organelle
1.35	2.05e-20	GO:0043227	membrane-bounded organelle
2.03	1.19e-19	GO:0044428	nuclear part
1.50	1.92e-19	GO:0044444	cytoplasmic part
1.30	4.31e-18	GO:0043229	intracellular organelle
2.01	6.24e-18	GO:0005829	cytosol
1.29	7.09e-18	GO:0043226	organelle
1.92	4.16e-17	GO:0031974	membrane-enclosed lumen
1.92	1.27e-16	GO:0070013	intracellular organelle lumen
1.91	2.02e-16	GO:0043233	organelle lumen
2.02	8.59e-16	GO:0031981	nuclear lumen
2.17	5.93e-14	GO:0005654	nucleoplasm
1.45	1.31e-13	GO:0005634	nucleus
1.57	2.76e-11	GO:0032991	macromolecular complex
2.13	2.92e-06	GO:0031967	organelle envelope
2.29	3.27e-06	GO:0005694	chromosome
2.32	5.45e-06	GO:0030529	ribonucleoprotein complex
2.09	5.84e-06	GO:0031975	envelope
1.45	2.52e-05	GO:0043234	protein complex
1.46	3.94e-05	GO:0043228	non-membrane-bounded organelle
1.46	3.94e-05	GO:0043232	intracellular non-membrane-bounded organelle
2.88	4.48e-05	GO:0005635	nuclear envelope
2.20	1.12e-04	GO:0005730	nucleolus
2.19	3.71e-04	GO:0044427	chromosomal part
4.43	8.99e-04	GO:0005643	nuclear pore
4.15	9.53e-04	GO:0071013	catalytic step 2 spliceosome
3.14	2.05e-03	GO:0000793	condensed chromosome
3.10	2.56e-03	GO:0031965	nuclear membrane
1.44	3.67e-03	GO:0031090	organelle membrane
3.73	3.82e-03	GO:0000776	kinetochore
3.10	4.34e-03	GO:0005681	spliceosomal complex
17.48	7.88e-03	GO:0005663	DNA replication factor C complex
3.69	8.47e-03	GO:0046930	pore complex
2.92	1.00e-02	GO:0000775	chromosome, centromeric region
1.48	1.68e-02	GO:0012505	endomembrane system
3.44	1.90e-02	GO:0042470	melanosome
3.44	1.90e-02	GO:0048770	pigment granule

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.52	9.37e-31	GO:0005515	protein binding
1.22	1.99e-19	GO:0005488	binding
1.74	3.85e-11	GO:0000166	nucleotide binding
2.27	1.61e-09	GO:0003723	RNA binding
1.77	2.60e-09	GO:0035639	purine ribonucleoside triphosphate binding
1.76	3.24e-09	GO:0017076	purine nucleotide binding
1.76	4.33e-09	GO:0032553	ribonucleotide binding
1.76	4.33e-09	GO:0032555	purine ribonucleotide binding
1.78	1.36e-07	GO:0030554	adenyl nucleotide binding
1.79	1.56e-07	GO:0005524	ATP binding
1.78	1.96e-07	GO:0032559	adenyl ribonucleotide binding
1.33	2.13e-06	GO:0003824	catalytic activity
4.15	1.21e-03	GO:0031625	ubiquitin protein ligase binding
1.82	3.18e-03	GO:0019899	enzyme binding
1.99	1.47e-02	GO:0016874	ligase activity
1.74	1.70e-02	GO:0017111	nucleoside-triphosphatase activity
1.71	2.53e-02	GO:0016462	pyrophosphatase activity
3.09	2.70e-02	GO:0051082	unfolded protein binding
1.70	2.83e-02	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.69	3.16e-02	GO:0016817	hydrolase activity, acting on acid anhydrides
2.44	3.58e-02	GO:0003924	GTPase activity
21.85	4.54e-02	GO:0005049	nuclear export signal receptor activity