Motif ID: CGUACCG

Z-value: 0.487


Mature miRNA associated with seed CGUACCG:

NamemiRBase Accession
hsa-miR-126 MIMAT0000445



Activity profile for motif CGUACCG.

activity profile for motif CGUACCG


Sorted Z-values histogram for motif CGUACCG

Sorted Z-values for motif CGUACCG



Network of associatons between targets according to the STRING database.



First level regulatory network of CGUACCG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_116207010 6.773 NM_144488
RGS3
regulator of G-protein signaling 3
chr9_+_116327301 6.659 NM_134427
RGS3
regulator of G-protein signaling 3
chr9_+_116342939 6.649 NM_021106
RGS3
regulator of G-protein signaling 3
chr9_+_116263706 6.594 NM_130795
RGS3
regulator of G-protein signaling 3
chr9_+_116356199 5.964 NM_144489
RGS3
regulator of G-protein signaling 3
chr5_-_57755787 5.903 NM_001252226
NM_006622
PLK2

polo-like kinase 2

chr4_+_76439653 4.342 NM_144721
THAP6
THAP domain containing 6
chr22_-_50746000 4.120 NM_012401
PLXNB2
plexin B2
chr9_+_139560193 3.331 NM_201446
EGFL7
EGF-like-domain, multiple 7
chr8_+_38854431 2.723 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr2_-_227663454 2.633 NM_005544
IRS1
insulin receptor substrate 1
chr9_+_139557378 2.359 NM_016215
EGFL7
EGF-like-domain, multiple 7
chr8_+_97505876 1.945 NM_002998
SDC2
syndecan 2
chr17_-_1359410 1.705 NM_005206
NM_016823
CRK

v-crk sarcoma virus CT10 oncogene homolog (avian)

chr2_-_176866925 1.517 NM_030650
KIAA1715
KIAA1715
chr1_+_15736387 1.315 NM_024329
EFHD2
EF-hand domain family, member D2
chr15_+_85923739 1.099 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr13_-_95364248 1.024 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr17_-_63052884 0.763 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_-_12419702 0.745 NM_002336
LRP6
low density lipoprotein receptor-related protein 6
chr22_+_35695792 0.604 NM_001135730
NM_001135732
NM_005488
TOM1


target of myb1 (chicken)


chr22_+_35695267 0.565 NM_001135729
TOM1
target of myb1 (chicken)
chr14_-_21572789 0.558 NM_001102454
ZNF219
zinc finger protein 219
chr10_-_735522 0.432 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr4_+_30721865 0.408 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr6_+_108882068 0.399 NM_001455
FOXO3
forkhead box O3
chr6_+_108881010 0.142 NM_201559
FOXO3
forkhead box O3
chr14_-_21567069 0.141 NM_001101672
ZNF219
zinc finger protein 219
chr14_-_21566728 0.136 NM_016423
ZNF219
zinc finger protein 219
chr12_+_69864065 0.120 NM_001042555
NM_006654
FRS2

fibroblast growth factor receptor substrate 2

chr5_-_32174397 0.003 NM_022130
GOLPH3
golgi phosphoprotein 3 (coat-protein)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
11.55 2.28e-03 GO:0007243 intracellular protein kinase cascade
11.55 2.28e-03 GO:0023014 signal transduction via phosphorylation event
5.25 4.89e-03 GO:0009966 regulation of signal transduction
9.92 5.42e-03 GO:0043549 regulation of kinase activity
9.58 6.62e-03 GO:0051338 regulation of transferase activity
22.46 7.11e-03 GO:0008286 insulin receptor signaling pathway
47.93 8.75e-03 GO:0000186 activation of MAPKK activity
4.57 1.49e-02 GO:0023051 regulation of signaling
17.32 1.97e-02 GO:0032869 cellular response to insulin stimulus
7.55 2.53e-02 GO:0007167 enzyme linked receptor protein signaling pathway
133.54 2.74e-02 GO:0048596 embryonic camera-type eye morphogenesis
4.87 2.94e-02 GO:0035556 intracellular signal transduction
7.28 3.10e-02 GO:0042325 regulation of phosphorylation
4.13 3.33e-02 GO:0007166 cell surface receptor linked signaling pathway
7.07 3.63e-02 GO:0019220 regulation of phosphate metabolic process
7.07 3.63e-02 GO:0051174 regulation of phosphorus metabolic process
2.94 4.02e-02 GO:0007165 signal transduction
3.97 4.55e-02 GO:0048583 regulation of response to stimulus
13.90 4.63e-02 GO:0071375 cellular response to peptide hormone stimulus
13.70 4.89e-02 GO:0032868 response to insulin stimulus
4.52 4.98e-02 GO:0065009 regulation of molecular function

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
209.82 1.79e-03 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
36.75 3.32e-03 GO:0035591 signaling adaptor activity
11.30 1.75e-02 GO:0032403 protein complex binding
63.89 2.13e-02 GO:0030971 receptor tyrosine kinase binding
61.23 2.32e-02 GO:0042169 SH2 domain binding
18.55 2.53e-02 GO:0030674 protein binding, bridging
17.39 3.06e-02 GO:0060090 binding, bridging
52.49 3.16e-02 GO:0005158 insulin receptor binding
45.93 4.14e-02 GO:0005080 protein kinase C binding