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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: E2F1..5.p2

Z-value: 8.692

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_136633934	271.584		MCM6	minichromosome maintenance complex component 6
chr6_-_52149541	265.258	NM_002388	MCM3	minichromosome maintenance complex component 3
chr2_-_136634002	263.986	NM_005915	MCM6	minichromosome maintenance complex component 6
chr2_+_10262853	242.470	NM_001034	RRM2	ribonucleotide reductase M2
chr6_-_52149516	237.550		MCM3	minichromosome maintenance complex component 3
chr6_-_52149472	228.893		MCM3	minichromosome maintenance complex component 3
chr10_+_62538250	226.166		CDK1	cyclin-dependent kinase 1
chr2_+_10262694	223.015	NM_001165931	RRM2	ribonucleotide reductase M2
chr10_+_62538088	211.912	NM_001170406 NM_001170407 NM_001786 NM_033379	CDK1	cyclin-dependent kinase 1
chr8_-_124408665	205.731		ATAD2	ATPase family, AAA domain containing 2
chr22_+_20105145	203.658		RANBP1	RAN binding protein 1
chr7_-_99698993	203.573		MCM7	minichromosome maintenance complex component 7
chr7_-_99699030	203.412		MCM7	minichromosome maintenance complex component 7
chrX_-_53449548	201.544		SMC1A	structural maintenance of chromosomes 1A
chr8_-_124408688	200.968	NM_014109	ATAD2	ATPase family, AAA domain containing 2
chr20_-_5100443	200.759	NM_182649	PCNA	proliferating cell nuclear antigen
chr22_+_20105076	196.971		RANBP1	RAN binding protein 1
chr22_+_20105095	196.736		RANBP1	RAN binding protein 1
chr15_-_64673569	196.103	NM_001029989 NM_014736	KIAA0101	KIAA0101
chr22_+_35796104	189.616	NM_006739	MCM5	minichromosome maintenance complex component 5
chr8_-_124408458	187.590		ATAD2	ATPase family, AAA domain containing 2
chr7_-_99698916	185.546		MCM7	minichromosome maintenance complex component 7
chr7_-_99699426	177.483	NM_005916	MCM7	minichromosome maintenance complex component 7
chr22_+_35796154	167.980		MCM5	minichromosome maintenance complex component 5
chr3_+_127317271	167.149		MCM2	minichromosome maintenance complex component 2
chr3_+_127317274	162.290		MCM2	minichromosome maintenance complex component 2
chr3_+_127317212	155.719	NM_004526	MCM2	minichromosome maintenance complex component 2
chr8_-_121457387	142.322		MRPL13	mitochondrial ribosomal protein L13
chr22_+_35796294	135.305		MCM5	minichromosome maintenance complex component 5
chr7_+_26241329	134.199		CBX3	chromobox homolog 3
chr22_+_20105068	132.348		RANBP1	RAN binding protein 1
chr10_-_58121019	130.402	NM_001005413 NM_007057 NM_032997	ZWINT	ZW10 interactor
chr10_-_58121011	129.884		ZWINT	ZW10 interactor
chr8_-_121457333	127.585		MRPL13	mitochondrial ribosomal protein L13
chr20_+_25388320	126.148	NM_021067	GINS1	GINS complex subunit 1 (Psf1 homolog)
chr8_-_121457625	125.498	NM_014078	MRPL13	mitochondrial ribosomal protein L13
chr6_+_24775640	121.587	NM_001251991	GMNN	geminin, DNA replication inhibitor
chr19_-_10305600	121.560		DNMT1	DNA (cytosine-5-)-methyltransferase 1
chr10_-_75006963	116.399	NM_015190	DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9
chr6_+_24775154	113.122	NM_001251989 NM_001251990 NM_015895	GMNN	geminin, DNA replication inhibitor
chr13_+_34392205	111.965	NM_002915 NM_181558	RFC3	replication factor C (activator 1) 3, 38kDa
chr14_-_55658205	110.868	NM_001146015 NM_014750	DLGAP5	discs, large (Drosophila) homolog-associated protein 5
chr6_+_135502445	110.137	NM_001130172 NM_001130173 NM_001161656 NM_001161657 NM_001161658 NM_001161659 NM_001161660 NM_005375	MYB	v-myb myeloblastosis viral oncogene homolog (avian)
chr4_-_170679027	109.692	NM_017867	C4orf27	chromosome 4 open reading frame 27
chr17_+_38444130	107.426		CDC6	cell division cycle 6 homolog (S. cerevisiae)
chr15_+_41624891	105.762	NM_001243142 NM_001243143 NM_001243144 NM_016359 NM_018454	NUSAP1	nucleolar and spindle associated protein 1
chr8_-_27695288	104.808	NM_018492	PBK	PDZ binding kinase
chr1_+_33116748	104.155	NM_001135255 NM_005610 NM_001135256	RBBP4	retinoblastoma binding protein 4
chr6_+_135502477	103.326		MYB	v-myb myeloblastosis viral oncogene homolog (avian)
chr19_-_10305536	103.262		DNMT1	DNA (cytosine-5-)-methyltransferase 1
chr20_+_25388328	98.959		GINS1	GINS complex subunit 1 (Psf1 homolog)
chr9_+_100745584	98.025		ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr2_+_232573226	95.581	NM_001099285 NM_002823	PTMA	prothymosin, alpha
chr7_+_26241372	93.857		CBX3	chromobox homolog 3
chr7_+_26241281	93.816	NM_016587	CBX3	chromobox homolog 3
chr7_+_26241044	93.155		CBX3	chromobox homolog 3
chr6_+_20402040	92.816	NM_001949	E2F3	E2F transcription factor 3
chr14_+_51706885	92.238	NM_030755	TMX1	thioredoxin-related transmembrane protein 1
chr17_+_30264140	91.897		SUZ12	suppressor of zeste 12 homolog (Drosophila)
chr13_+_34392254	89.346		RFC3	replication factor C (activator 1) 3, 38kDa
chr16_-_85722503	88.949		GINS2	GINS complex subunit 2 (Psf2 homolog)
chr16_-_85722587	88.642	NM_016095	GINS2	GINS complex subunit 2 (Psf2 homolog)
chr19_-_10305645	87.765	NM_001130823 NM_001379	DNMT1	DNA (cytosine-5-)-methyltransferase 1
chr17_+_30264039	87.336	NM_015355	SUZ12	suppressor of zeste 12 homolog (Drosophila)
chr15_-_66648991	86.805	NM_017858	TIPIN	TIMELESS interacting protein
chr6_+_135502521	86.484		MYB	v-myb myeloblastosis viral oncogene homolog (avian)
chr7_-_44887567	86.479		H2AFV	H2A histone family, member V
chr11_+_4116059	86.017		RRM1	ribonucleotide reductase M1
chr17_+_30264065	85.782		SUZ12	suppressor of zeste 12 homolog (Drosophila)
chr15_+_41625052	81.741		NUSAP1	nucleolar and spindle associated protein 1
chr8_+_128748312	81.488	NM_002467	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)
chr7_+_26240830	81.448	NM_007276	CBX3	chromobox homolog 3
chr7_-_158497432	80.910	NM_017760	NCAPG2	non-SMC condensin II complex, subunit G2
chr11_-_118966175	80.348	NM_002105	H2AFX	H2A histone family, member X
chr8_+_128748476	80.228		MYC	v-myc myelocytomatosis viral oncogene homolog (avian)
chr17_+_38444134	80.064	NM_001254	CDC6	cell division cycle 6 homolog (S. cerevisiae)
chr13_+_114239047	79.273	NM_007111	TFDP1	transcription factor Dp-1
chr11_+_4115923	79.040	NM_001033	RRM1	ribonucleotide reductase M1
chr7_-_44887620	78.718		H2AFV	H2A histone family, member V
chr11_-_57103324	78.602	NM_003146	SSRP1	structure specific recognition protein 1
chr11_+_125495853	78.131		CHEK1	checkpoint kinase 1
chr9_+_86595636	76.056	NM_024945	RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
chr6_-_17706617	75.377	NM_005124	NUP153	nucleoporin 153kDa
chr11_+_64808375	74.180	NM_013299	SAC3D1	SAC3 domain containing 1
chr1_+_62902735	73.674		USP1	ubiquitin specific peptidase 1
chr2_-_47168902	73.057	NM_001171508 NM_001171511	MCFD2	multiple coagulation factor deficiency 2
chr11_+_64808395	73.023		SAC3D1	SAC3 domain containing 1
chr5_-_79950307	72.691		DHFR	dihydrofolate reductase
chr7_-_148581377	72.094		EZH2	enhancer of zeste homolog 2 (Drosophila)
chr1_-_225615701	71.663		LBR	lamin B receptor
chrX_+_123095555	70.421	NM_001042750 NM_001042751 NM_006603	STAG2	stromal antigen 2
chr17_+_38444151	70.237		CDC6	cell division cycle 6 homolog (S. cerevisiae)
chrX_+_133594225	69.737		HPRT1	hypoxanthine phosphoribosyltransferase 1
chr17_-_17184011	69.525	NM_001199125	COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr7_+_139044696	69.366		LUC7L2	LUC7-like 2 (S. cerevisiae)
chr1_+_165797060	69.047		UCK2	uridine-cytidine kinase 2
chr7_-_26240364	68.851		HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1
chr7_-_148581297	68.461		EZH2	enhancer of zeste homolog 2 (Drosophila)
chr11_-_77850687	68.405	NM_001007027 NM_024079	ALG8	asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
chr7_+_139044701	68.382		LUC7L2	LUC7-like 2 (S. cerevisiae)
chr16_-_12009568	68.218
chr7_-_148581403	67.949	NM_001203247 NM_001203248 NM_004456 NM_152998	EZH2	enhancer of zeste homolog 2 (Drosophila)
chr2_+_47630246	67.894	NM_000251	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr5_-_79950783	67.335	NM_000791	DHFR	dihydrofolate reductase
chr1_-_205719340	66.791	NM_022731	NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1
chr12_-_31479120	66.436	NM_001135811 NM_021238 NM_001135812	FAM60A	family with sequence similarity 60, member A
chr1_-_26232643	66.302	NM_203401	STMN1	stathmin 1
chrX_+_106871653	65.835	NM_001204402 NM_002764	PRPS1	phosphoribosyl pyrophosphate synthetase 1
chr10_+_13203547	65.518	NM_018518 NM_182751	MCM10	minichromosome maintenance complex component 10
chr9_+_100745456	64.719	NM_006401	ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_62902653	64.073		USP1	ubiquitin specific peptidase 1
chr1_-_26233367	64.004	NM_203399	STMN1	stathmin 1
chr1_+_28157322	63.829	NM_002713 NM_138558	PPP1R8	protein phosphatase 1, regulatory subunit 8
chr12_+_109535922	62.998	NM_003362	UNG	uracil-DNA glycosylase
chr7_-_148581359	62.911		EZH2	enhancer of zeste homolog 2 (Drosophila)
chr16_-_12009918	62.864		GSPT1	G1 to S phase transition 1
chrX_+_118708536	62.629		UBE2A	ubiquitin-conjugating enzyme E2A
chr9_+_91926109	62.622	NM_001827	CKS2	CDC28 protein kinase regulatory subunit 2
chr1_+_62902708	62.593		USP1	ubiquitin specific peptidase 1
chrX_+_106871739	62.480		PRPS1	phosphoribosyl pyrophosphate synthetase 1
chr6_-_153304093	62.394	NM_012177	FBXO5	F-box protein 5
chr1_+_28157335	62.349		PPP1R8	protein phosphatase 1, regulatory subunit 8
chr7_-_26240320	62.304		HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1
chr1_-_24306739	62.284		SRSF10	serine/arginine-rich splicing factor 10
chr12_-_31479038	62.227		FAM60A	family with sequence similarity 60, member A
chrX_+_133594171	61.761	NM_000194	HPRT1	hypoxanthine phosphoribosyltransferase 1
chr1_-_205719157	61.558		NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1
chr15_-_41624760	61.462	NM_007280	OIP5	Opa interacting protein 5
chr19_+_16187315	61.329		TPM4	tropomyosin 4
chr9_-_35079520	60.594		FANCG	Fanconi anemia, complementation group G
chr1_-_28241233	60.519	NM_002946	RPA2	replication protein A2, 32kDa
chr1_+_212209129	60.415		DTL	denticleless homolog (Drosophila)
chr14_-_50154920	60.194		POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)
chr12_-_31479084	60.160		FAM60A	family with sequence similarity 60, member A
chr1_-_33502470	59.729		AK2	adenylate kinase 2
chr7_-_26240366	59.538	NM_002137 NM_031243	HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1
chr4_-_56502358	58.878	NM_006681	NMU	neuromedin U
chr1_+_28157251	58.373	NM_014110	PPP1R8	protein phosphatase 1, regulatory subunit 8
chr14_-_50155097	58.342	NM_001197330 NM_001197331 NM_002692	POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)
chr9_-_35079751	58.315	NM_004629	FANCG	Fanconi anemia, complementation group G
chr17_-_56084514	58.227		SRSF1	serine/arginine-rich splicing factor 1
chr14_+_35452103	58.118	NM_001146282 NM_003136	SRP54	signal recognition particle 54kDa
chr19_-_1095380	58.038	NM_002695	POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr6_-_13814546	57.704	NM_001031713	CCDC90A	coiled-coil domain containing 90A
chr1_-_225615787	56.673	NM_002296	LBR	lamin B receptor
chr3_-_133380626	56.579	NM_007027	TOPBP1	topoisomerase (DNA) II binding protein 1
chrX_+_133594297	56.441		HPRT1	hypoxanthine phosphoribosyltransferase 1
chr17_-_56084611	56.316		SRSF1	serine/arginine-rich splicing factor 1
chr15_+_41625152	56.178		NUSAP1	nucleolar and spindle associated protein 1
chr2_-_47168870	55.742		MCFD2	multiple coagulation factor deficiency 2
chr16_-_23607603	55.524	NM_005003	NDUFAB1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr2_+_47630291	55.517		MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr18_+_19192229	55.316	NM_006938	SNRPD1	small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr7_-_148581379	55.281		EZH2	enhancer of zeste homolog 2 (Drosophila)
chr7_+_139044604	55.173	NM_016019	LUC7L2	LUC7-like 2 (S. cerevisiae)
chrX_+_123095598	55.013		STAG2	stromal antigen 2
chrX_-_53449610	54.696	NM_006306	SMC1A	structural maintenance of chromosomes 1A
chr1_+_212208918	54.667	NM_016448	DTL	denticleless homolog (Drosophila)
chr14_+_35452194	54.512		SRP54	signal recognition particle 54kDa
chr3_+_44803208	54.257	NM_020242	KIF15	kinesin family member 15
chrX_+_118708540	53.668		UBE2A	ubiquitin-conjugating enzyme E2A
chr16_-_12009734	53.527		GSPT1	G1 to S phase transition 1
chr3_+_44803280	53.476		KIF15	kinesin family member 15
chr5_-_79950348	53.425		DHFR	dihydrofolate reductase
chr19_+_16187306	53.421		TPM4	tropomyosin 4
chr1_-_26232890	52.848	NM_001145454 NM_005563	STMN1	stathmin 1
chr12_-_111180636	52.294		PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme
chr2_-_176046120	52.263	NM_001002258 NM_001190329 NM_001689	ATP5G3	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chrX_+_131157635	52.115	NM_001042452	MST4	serine/threonine protein kinase MST4
chr11_+_47586887	51.920	NM_001143984 NM_175732	PTPMT1	protein tyrosine phosphatase, mitochondrial 1
chr19_-_1095316	51.087		POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr17_-_56084571	51.047		SRSF1	serine/arginine-rich splicing factor 1
chr2_+_47630190	50.932		MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chrX_+_131157231	50.405	NM_001042453 NM_016542	MST4	serine/threonine protein kinase MST4
chr1_-_33502464	50.312		AK2	adenylate kinase 2
chrX_+_118708476	50.153	NM_003336 NM_181762	UBE2A	ubiquitin-conjugating enzyme E2A
chr10_+_112327411	50.028	NM_005445	SMC3	structural maintenance of chromosomes 3
chr17_-_78120759	50.001	NM_014740	EIF4A3	eukaryotic translation initiation factor 4A3
chr12_-_111180730	49.946	NM_001244974 NM_002710	PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme
chr19_-_1095373	49.924		POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr14_+_75348592	49.702	NM_001244883 NM_001933	DLST	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr2_-_31361364	49.681
chr10_+_124913884	49.548		BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)
chr16_-_50402685	49.286	NM_001173984 NM_013263	BRD7	bromodomain containing 7
chr12_+_109535377	48.855	NM_080911	UNG	uracil-DNA glycosylase
chr7_+_94285620	48.752	NM_001040152 NM_001184961 NM_001184962 NM_015068	PEG10	paternally expressed 10
chr17_+_3572089	48.681	NM_001014764 NM_031298	TMEM93	transmembrane protein 93
chr17_-_17184500	48.670		COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr3_+_14220343	48.652		LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_27440342	48.365		CAD	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr17_+_57642885	48.287	NM_001166301 NM_024612	DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr11_-_14541886	48.284	NM_001143937 NM_002786	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chr10_-_123734708	47.646	NM_001167865 NM_017615	NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)
chr8_+_48873533	47.395		MCM4	minichromosome maintenance complex component 4
chr11_-_118966103	47.319		H2AFX	H2A histone family, member X
chr1_-_245027791	46.878		HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr3_-_141868208	46.608	NM_001178138 NM_001178139	TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)
chr7_-_73668732	46.495	NM_002914 NM_181471	RFC2	replication factor C (activator 1) 2, 40kDa
chr2_+_132250500	46.389		LOC150776	sphingomyelin phosphodiesterase 4, neutral membrane pseudogene
chr7_+_94285676	46.131	NM_001172437 NM_001172438	PEG10	paternally expressed 10

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.36	7.49e-50	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.52	2.20e-46	GO:0090304	nucleic acid metabolic process
2.15	1.01e-43	GO:0034641	cellular nitrogen compound metabolic process
2.12	2.95e-43	GO:0006807	nitrogen compound metabolic process
3.33	1.81e-41	GO:0007049	cell cycle
1.87	1.66e-40	GO:0044260	cellular macromolecule metabolic process
1.65	1.08e-39	GO:0044237	cellular metabolic process
3.74	1.79e-35	GO:0022403	cell cycle phase
3.45	4.58e-35	GO:0022402	cell cycle process
1.73	2.68e-34	GO:0043170	macromolecule metabolic process
1.59	3.01e-33	GO:0044238	primary metabolic process
1.53	6.06e-33	GO:0008152	metabolic process
3.84	1.45e-31	GO:0000278	mitotic cell cycle
3.70	2.05e-29	GO:0006259	DNA metabolic process
1.26	1.21e-23	GO:0009987	cellular process
5.77	1.56e-23	GO:0006260	DNA replication
3.29	1.01e-22	GO:0051276	chromosome organization
4.41	3.72e-22	GO:0008380	RNA splicing
5.23	3.18e-21	GO:0000375	RNA splicing, via transesterification reactions
4.32	3.30e-21	GO:0051325	interphase
3.37	6.11e-21	GO:0016071	mRNA metabolic process
4.33	6.52e-21	GO:0051329	interphase of mitotic cell cycle
2.22	6.80e-21	GO:0006996	organelle organization
3.12	1.09e-20	GO:0006396	RNA processing
2.15	3.43e-20	GO:0016070	RNA metabolic process
5.07	2.98e-19	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
5.07	2.98e-19	GO:0000398	nuclear mRNA splicing, via spliceosome
2.07	4.49e-19	GO:0010467	gene expression
1.71	4.93e-19	GO:0071840	cellular component organization or biogenesis
1.89	1.98e-18	GO:0044249	cellular biosynthetic process
1.82	2.55e-18	GO:0071841	cellular component organization or biogenesis at cellular level
1.70	6.91e-18	GO:0016043	cellular component organization
3.61	1.55e-17	GO:0006397	mRNA processing
5.65	1.96e-17	GO:0000082	G1/S transition of mitotic cell cycle
3.76	4.04e-17	GO:0006281	DNA repair
3.18	4.07e-17	GO:0006974	response to DNA damage stimulus
6.29	6.74e-17	GO:0051320	S phase
3.71	9.51e-17	GO:0010564	regulation of cell cycle process
3.38	1.09e-16	GO:0000279	M phase
1.80	1.44e-16	GO:0071842	cellular component organization at cellular level
1.82	2.05e-16	GO:0009058	biosynthetic process
6.23	3.10e-16	GO:0000084	S phase of mitotic cell cycle
2.04	6.42e-16	GO:0034645	cellular macromolecule biosynthetic process
2.02	2.10e-15	GO:0009059	macromolecule biosynthetic process
7.48	1.33e-14	GO:0006261	DNA-dependent DNA replication
5.27	2.09e-14	GO:0006310	DNA recombination
2.77	2.87e-14	GO:0051726	regulation of cell cycle
2.46	1.17e-13	GO:0033554	cellular response to stress
4.13	5.78e-13	GO:0000075	cell cycle checkpoint
3.56	1.93e-12	GO:0000280	nuclear division
3.56	1.93e-12	GO:0007067	mitosis
3.97	2.68e-12	GO:0071156	regulation of cell cycle arrest
3.46	6.73e-12	GO:0000087	M phase of mitotic cell cycle
3.45	7.83e-12	GO:0048285	organelle fission
10.69	1.58e-10	GO:0006271	DNA strand elongation involved in DNA replication
2.02	5.44e-10	GO:0044085	cellular component biogenesis
9.97	6.83e-10	GO:0022616	DNA strand elongation
2.20	3.86e-09	GO:0043933	macromolecular complex subunit organization
2.33	3.95e-09	GO:0065003	macromolecular complex assembly
2.89	1.16e-08	GO:0034622	cellular macromolecular complex assembly
2.92	1.24e-08	GO:0051301	cell division
2.58	1.45e-08	GO:0034621	cellular macromolecular complex subunit organization
11.05	2.05e-08	GO:0006270	DNA-dependent DNA replication initiation
5.52	2.17e-08	GO:0000216	M/G1 transition of mitotic cell cycle
4.68	2.57e-08	GO:0051028	mRNA transport
4.44	4.14e-08	GO:0050657	nucleic acid transport
4.44	4.14e-08	GO:0050658	RNA transport
4.44	4.14e-08	GO:0051236	establishment of RNA localization
2.57	5.65e-08	GO:0006325	chromatin organization
4.29	9.71e-08	GO:0006403	RNA localization
1.97	1.11e-07	GO:0022607	cellular component assembly
3.52	9.78e-07	GO:0006913	nucleocytoplasmic transport
6.23	1.32e-06	GO:0051053	negative regulation of DNA metabolic process
3.48	1.33e-06	GO:0051169	nuclear transport
14.03	1.55e-06	GO:0071897	DNA biosynthetic process
4.36	1.71e-06	GO:0007059	chromosome segregation
3.82	1.71e-06	GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport
3.67	2.42e-06	GO:0071103	DNA conformation change
10.29	2.47e-06	GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle
4.79	3.11e-06	GO:0051168	nuclear export
1.94	7.87e-06	GO:0010605	negative regulation of macromolecule metabolic process
2.05	8.14e-06	GO:0071844	cellular component assembly at cellular level
5.39	1.65e-05	GO:0006406	mRNA export from nucleus
9.84	2.57e-05	GO:0032201	telomere maintenance via semi-conservative replication
3.60	2.57e-05	GO:0006333	chromatin assembly or disassembly
1.41	3.08e-05	GO:0060255	regulation of macromolecule metabolic process
3.68	3.10e-05	GO:0006323	DNA packaging
1.86	3.18e-05	GO:0009892	negative regulation of metabolic process
4.03	4.00e-05	GO:0034728	nucleosome organization
6.23	4.41e-05	GO:0006369	termination of RNA polymerase II transcription
1.89	4.69e-05	GO:0031324	negative regulation of cellular metabolic process
9.35	4.89e-05	GO:0000722	telomere maintenance via recombination
3.84	5.09e-05	GO:0071824	protein-DNA complex subunit organization
1.48	5.85e-05	GO:0044267	cellular protein metabolic process
3.88	8.40e-05	GO:0065004	protein-DNA complex assembly
7.91	8.44e-05	GO:0006312	mitotic recombination
6.40	9.98e-05	GO:0008156	negative regulation of DNA replication
4.82	1.05e-04	GO:0006405	RNA export from nucleus
2.21	1.19e-04	GO:0070271	protein complex biogenesis
3.39	1.74e-04	GO:0051052	regulation of DNA metabolic process
1.47	1.96e-04	GO:0048522	positive regulation of cellular process
1.37	2.39e-04	GO:0031323	regulation of cellular metabolic process
9.35	2.56e-04	GO:0007062	sister chromatid cohesion
8.13	2.61e-04	GO:0090329	regulation of DNA-dependent DNA replication
5.93	2.80e-04	GO:0000070	mitotic sister chromatid segregation
3.64	2.80e-04	GO:0031570	DNA integrity checkpoint
5.46	2.98e-04	GO:0000723	telomere maintenance
4.75	3.23e-04	GO:0031124	mRNA 3'-end processing
3.86	3.90e-04	GO:0031497	chromatin assembly
5.34	3.96e-04	GO:0007051	spindle organization
5.34	3.96e-04	GO:0032200	telomere organization
1.34	4.78e-04	GO:0019222	regulation of metabolic process
2.06	5.52e-04	GO:0055086	nucleobase, nucleoside and nucleotide metabolic process
2.14	5.83e-04	GO:0006461	protein complex assembly
2.02	6.71e-04	GO:0071822	protein complex subunit organization
7.48	6.77e-04	GO:0002200	somatic diversification of immune receptors
5.53	7.09e-04	GO:0000819	sister chromatid segregation
3.57	7.63e-04	GO:0051321	meiotic cell cycle
3.86	7.70e-04	GO:0006334	nucleosome assembly
4.24	7.84e-04	GO:0031123	RNA 3'-end processing
8.42	8.01e-04	GO:0006298	mismatch repair
8.42	8.01e-04	GO:2000104	negative regulation of DNA-dependent DNA replication
1.47	1.19e-03	GO:0048523	negative regulation of cellular process
1.41	1.27e-03	GO:0048518	positive regulation of biological process
8.02	1.33e-03	GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus
8.02	1.33e-03	GO:0016444	somatic cell DNA recombination
9.35	1.34e-03	GO:0006297	nucleotide-excision repair, DNA gap filling
1.84	1.47e-03	GO:0046907	intracellular transport
2.45	1.54e-03	GO:0006366	transcription from RNA polymerase II promoter
2.51	1.71e-03	GO:0007346	regulation of mitotic cell cycle
2.07	1.72e-03	GO:0006753	nucleoside phosphate metabolic process
2.07	1.72e-03	GO:0009117	nucleotide metabolic process
2.28	1.75e-03	GO:0016568	chromatin modification
3.98	2.08e-03	GO:0006275	regulation of DNA replication
2.21	2.27e-03	GO:0006091	generation of precursor metabolites and energy
3.05	2.30e-03	GO:0000226	microtubule cytoskeleton organization
3.43	2.80e-03	GO:0007126	meiosis
3.43	2.80e-03	GO:0051327	M phase of meiotic cell cycle
1.65	3.24e-03	GO:0044248	cellular catabolic process
2.37	3.35e-03	GO:0009141	nucleoside triphosphate metabolic process
1.93	3.85e-03	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
12.47	3.94e-03	GO:0002566	somatic diversification of immune receptors via somatic mutation
12.47	3.94e-03	GO:0016446	somatic hypermutation of immunoglobulin genes
1.42	4.91e-03	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.33	5.04e-03	GO:0080090	regulation of primary metabolic process
1.90	5.70e-03	GO:0009057	macromolecule catabolic process
1.90	5.70e-03	GO:0051172	negative regulation of nitrogen compound metabolic process
1.87	5.80e-03	GO:0046483	heterocycle metabolic process
1.38	6.12e-03	GO:0051171	regulation of nitrogen compound metabolic process
1.98	6.82e-03	GO:0044265	cellular macromolecule catabolic process
6.03	6.84e-03	GO:0010833	telomere maintenance via telomere lengthening
4.01	8.11e-03	GO:0006302	double-strand break repair
1.55	8.26e-03	GO:0009056	catabolic process
1.69	8.29e-03	GO:0032774	RNA biosynthetic process
1.62	9.33e-03	GO:0010604	positive regulation of macromolecule metabolic process
11.22	9.41e-03	GO:0006301	postreplication repair
1.40	9.89e-03	GO:0010556	regulation of macromolecule biosynthetic process
1.19	9.96e-03	GO:0050794	regulation of cellular process
1.41	1.05e-02	GO:0048519	negative regulation of biological process
1.83	1.20e-02	GO:0031327	negative regulation of cellular biosynthetic process
2.30	1.33e-02	GO:0009144	purine nucleoside triphosphate metabolic process
1.86	1.48e-02	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.71	1.58e-02	GO:0006351	transcription, DNA-dependent
2.07	1.66e-02	GO:0016032	viral reproduction
3.79	1.68e-02	GO:0006353	transcription termination, DNA-dependent
3.07	1.70e-02	GO:0045333	cellular respiration
1.57	1.85e-02	GO:0009893	positive regulation of metabolic process
18.70	1.89e-02	GO:0019985	translesion synthesis
2.19	2.18e-02	GO:0009259	ribonucleotide metabolic process
1.34	2.18e-02	GO:0019538	protein metabolic process
1.38	2.18e-02	GO:0006950	response to stress
1.79	2.30e-02	GO:0009890	negative regulation of biosynthetic process
1.37	2.41e-02	GO:0010468	regulation of gene expression
6.80	2.50e-02	GO:0016445	somatic diversification of immunoglobulins
1.81	2.77e-02	GO:0010558	negative regulation of macromolecule biosynthetic process
3.18	2.91e-02	GO:0000077	DNA damage checkpoint
1.64	3.27e-02	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.92	3.33e-02	GO:0044283	small molecule biosynthetic process
4.32	3.43e-02	GO:0033044	regulation of chromosome organization
7.70	3.48e-02	GO:0016447	somatic recombination of immunoglobulin gene segments
2.92	3.54e-02	GO:0022900	electron transport chain
2.00	3.57e-02	GO:0072521	purine-containing compound metabolic process
1.35	3.95e-02	GO:0031326	regulation of cellular biosynthetic process
11.69	4.94e-02	GO:0000731	DNA synthesis involved in DNA repair
11.69	4.94e-02	GO:0045910	negative regulation of DNA recombination
1.56	4.94e-02	GO:0031325	positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
2.97	2.02e-77	GO:0044428	nuclear part
2.74	7.75e-65	GO:0070013	intracellular organelle lumen
2.70	1.34e-64	GO:0031974	membrane-enclosed lumen
2.99	3.20e-64	GO:0031981	nuclear lumen
2.71	6.25e-64	GO:0043233	organelle lumen
1.88	5.57e-63	GO:0044446	intracellular organelle part
1.87	1.09e-62	GO:0044422	organelle part
1.55	6.57e-61	GO:0043227	membrane-bounded organelle
1.48	3.33e-60	GO:0043226	organelle
1.54	4.53e-60	GO:0043231	intracellular membrane-bounded organelle
1.37	9.80e-60	GO:0044424	intracellular part
1.47	1.73e-59	GO:0043229	intracellular organelle
3.29	1.23e-56	GO:0005654	nucleoplasm
1.35	1.25e-56	GO:0005622	intracellular
1.82	1.21e-54	GO:0005634	nucleus
1.86	3.85e-31	GO:0032991	macromolecular complex
3.53	2.45e-26	GO:0005694	chromosome
3.41	7.57e-20	GO:0044427	chromosomal part
1.81	2.26e-19	GO:0043228	non-membrane-bounded organelle
1.81	2.26e-19	GO:0043232	intracellular non-membrane-bounded organelle
2.81	3.71e-19	GO:0044451	nucleoplasm part
3.10	2.05e-17	GO:0030529	ribonucleoprotein complex
1.32	3.16e-17	GO:0005737	cytoplasm
4.36	3.90e-16	GO:0000228	nuclear chromosome
1.66	1.58e-14	GO:0043234	protein complex
1.10	4.35e-13	GO:0044464	cell part
1.10	4.52e-13	GO:0005623	cell
4.89	9.38e-13	GO:0005681	spliceosomal complex
4.29	2.61e-12	GO:0044454	nuclear chromosome part
3.76	8.08e-12	GO:0016604	nuclear body
3.58	5.02e-11	GO:0000785	chromatin
2.58	5.24e-10	GO:0005730	nucleolus
5.68	6.64e-10	GO:0071013	catalytic step 2 spliceosome
2.21	9.99e-09	GO:0031967	organelle envelope
2.17	2.41e-08	GO:0031975	envelope
1.31	3.69e-08	GO:0044444	cytoplasmic part
11.43	9.20e-08	GO:0030530	heterogeneous nuclear ribonucleoprotein complex
7.08	1.16e-06	GO:0005657	replication fork
1.54	4.80e-06	GO:0005829	cytosol
2.48	1.67e-05	GO:0019866	organelle inner membrane
4.33	1.96e-05	GO:0000790	nuclear chromatin
5.29	2.94e-05	GO:0034708	methyltransferase complex
5.29	2.94e-05	GO:0035097	histone methyltransferase complex
3.59	3.49e-05	GO:0016607	nuclear speck
3.36	3.59e-05	GO:0000793	condensed chromosome
2.71	5.17e-05	GO:0005635	nuclear envelope
8.86	8.22e-05	GO:0031519	PcG protein complex
3.74	2.31e-04	GO:0032993	protein-DNA complex
14.03	2.45e-04	GO:0042555	MCM complex
3.27	6.07e-04	GO:0044455	mitochondrial membrane part
12.47	7.01e-04	GO:0035098	ESC/E(Z) complex
1.58	7.21e-04	GO:0005739	mitochondrion
1.85	7.49e-04	GO:0044429	mitochondrial part
4.13	9.80e-04	GO:0034399	nuclear periphery
4.07	1.19e-03	GO:0005643	nuclear pore
2.26	1.83e-03	GO:0005743	mitochondrial inner membrane
2.90	2.76e-03	GO:0000775	chromosome, centromeric region
3.61	2.95e-03	GO:0046930	pore complex
9.35	6.70e-03	GO:0032300	mismatch repair complex
3.92	8.21e-03	GO:0016363	nuclear matrix
3.29	9.93e-03	GO:0016585	chromatin remodeling complex
1.91	1.03e-02	GO:0005740	mitochondrial envelope
2.51	1.31e-02	GO:0005819	spindle
4.01	1.35e-02	GO:0016605	PML body
3.74	2.78e-02	GO:0000123	histone acetyltransferase complex
3.68	3.30e-02	GO:0005746	mitochondrial respiratory chain
1.87	3.35e-02	GO:0031966	mitochondrial membrane
4.25	3.60e-02	GO:0000792	heterochromatin
5.95	4.28e-02	GO:0043596	nuclear replication fork

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.53	1.92e-37	GO:0005515	protein binding
1.24	2.67e-25	GO:0005488	binding
1.70	8.62e-19	GO:0003676	nucleic acid binding
2.57	5.54e-17	GO:0003723	RNA binding
1.73	6.24e-13	GO:0000166	nucleotide binding
3.42	1.53e-07	GO:0003682	chromatin binding
1.56	1.54e-07	GO:0003677	DNA binding
5.58	2.22e-06	GO:0003697	single-stranded DNA binding
5.05	1.18e-05	GO:0008094	DNA-dependent ATPase activity
3.03	2.97e-05	GO:0043566	structure-specific DNA binding
7.09	7.85e-05	GO:0034061	DNA polymerase activity
1.51	2.21e-04	GO:0035639	purine ribonucleoside triphosphate binding
7.19	2.52e-04	GO:0003887	DNA-directed DNA polymerase activity
1.49	4.73e-04	GO:0017076	purine nucleotide binding
1.48	5.66e-04	GO:0032553	ribonucleotide binding
1.48	5.66e-04	GO:0032555	purine ribonucleotide binding
1.24	9.09e-04	GO:0003824	catalytic activity
3.89	1.43e-03	GO:0003729	mRNA binding
9.35	1.71e-03	GO:0030983	mismatched DNA binding
1.52	1.88e-03	GO:0005524	ATP binding
4.68	3.40e-03	GO:0003684	damaged DNA binding
1.50	3.86e-03	GO:0032559	adenyl ribonucleotide binding
1.49	4.98e-03	GO:0030554	adenyl nucleotide binding
1.71	6.02e-03	GO:0016462	pyrophosphatase activity
1.72	6.46e-03	GO:0017111	nucleoside-triphosphatase activity
1.71	6.87e-03	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.70	7.83e-03	GO:0016817	hydrolase activity, acting on acid anhydrides
2.06	1.50e-02	GO:0016887	ATPase activity
3.54	1.84e-02	GO:0042393	histone binding
4.68	2.03e-02	GO:0003678	DNA helicase activity
14.96	2.18e-02	GO:0019238	cyclohydrolase activity