Motif ID: EN1,2.p2

Z-value: 2.454


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_1552507050.426.7e-11Click!
EN1chr2_-_1196057580.091.8e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_139872014 54.739 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr9_+_139871954 52.893 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr11_-_5248180 52.413 NM_000518
HBB
hemoglobin, beta
chr14_-_21271002 46.105 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr14_-_21270537 37.932 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr12_+_21679190 27.923 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr8_-_87755880 27.037 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr5_+_40909558 25.191 NM_000587
C7
complement component 7
chr3_-_38835500 24.054 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr20_+_34556528 22.600 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr1_-_163172624 22.187 NM_001195303
RGS5
regulator of G-protein signaling 5
chr2_+_103035148 22.135 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr14_-_53620032 21.985 NM_001160147
NM_001160148
NM_030637
DDHD1


DDHD domain containing 1


chr5_+_40909617 21.924 C7
complement component 7
chr16_+_31085751 21.876 ZNF646
zinc finger protein 646
chr6_-_32013806 20.334 NM_032470
TNXB
tenascin XB
chr17_+_4046417 20.074 NM_144611
CYB5D2
cytochrome b5 domain containing 2
chr4_+_74281884 19.996 ALB
albumin
chr15_-_74659926 19.902 NM_000781
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr16_+_31085722 19.889 NM_014699
ZNF646
zinc finger protein 646
chr12_-_105322056 19.428 NM_032148
SLC41A2
solute carrier family 41, member 2
chr1_-_163113129 19.394 RGS5
regulator of G-protein signaling 5
chr7_+_117864711 19.247 NM_019644
ANKRD7
ankyrin repeat domain 7
chr11_-_35547144 18.607 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr17_+_45810609 18.548 NM_013351
TBX21
T-box 21
chr10_+_17851342 18.332 NM_002438
MRC1
mannose receptor, C type 1
chr11_+_49053151 18.317 NM_001206626
LOC283116
tripartite motif-containing protein LOC642612-like
chr12_-_11548485 17.859 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr17_-_4046298 17.770 ZZEF1
zinc finger, ZZ-type with EF-hand domain 1
chr4_-_39033981 17.647 NM_024943
TMEM156
transmembrane protein 156
chr10_+_75532252 17.071 FUT11
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
chr10_+_105037441 16.899 INA
internexin neuronal intermediate filament protein, alpha
chr1_-_212208779 16.855 NM_001199809
NM_001199811
NM_001199812
NM_015434
INTS7



integrator complex subunit 7



chr16_-_31085503 16.660 NM_024706
ZNF668
zinc finger protein 668
chr1_+_160765927 16.364 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr6_+_41303527 16.217 NM_001199509
NM_001199510
NM_004828
NCR2


natural cytotoxicity triggering receptor 2


chr17_-_29624249 16.133 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr17_-_4046190 16.091


chr14_-_93799371 15.374 NM_001002860
NM_018167
BTBD7

BTB (POZ) domain containing 7

chr1_+_86934525 15.346 NM_001285
CLCA1
chloride channel accessory 1
chr16_-_20364029 15.326 NM_001008389
NM_003361
UMOD

uromodulin

chr1_+_171154387 15.194 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr1_-_155145732 15.179 NM_173852
KRTCAP2
keratinocyte associated protein 2
chr9_-_34691135 15.086 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr10_-_104179468 14.877 PSD
pleckstrin and Sec7 domain containing
chr11_+_5009420 14.505 NM_021801
MMP26
matrix metallopeptidase 26
chrX_+_128913897 14.473 SASH3
SAM and SH3 domain containing 3
chr6_+_32407618 14.287 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr19_-_46295785 14.055 NM_004943
DMWD
dystrophia myotonica, WD repeat containing
chr2_-_217540722 13.680 IGFBP5
insulin-like growth factor binding protein 5
chr6_-_52668599 13.571 NM_145740
GSTA1
glutathione S-transferase alpha 1
chrX_+_103031433 13.371 NM_001128834
PLP1
proteolipid protein 1
chrX_+_38420690 13.345 NM_004615
TSPAN7
tetraspanin 7
chr2_-_192015706 13.095 STAT4
signal transducer and activator of transcription 4
chr2_-_163008913 13.016 NM_002054
GCG
glucagon
chr8_-_82395401 12.970 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chrX_+_128913881 12.836 NM_018990
SASH3
SAM and SH3 domain containing 3
chr17_-_43487747 12.790 ARHGAP27
Rho GTPase activating protein 27
chr16_-_3627353 12.746 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr8_+_11141983 12.698 NM_015458
MTMR9
myotubularin related protein 9
chr8_+_11142314 12.628 MTMR9
myotubularin related protein 9
chr3_+_138066489 11.990 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr17_-_56591900 11.923 MTMR4
myotubularin related protein 4
chr2_-_152590983 11.876 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr22_+_23054862 11.836 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr11_-_57004674 11.711 NM_005161
APLNR
apelin receptor
chr17_+_37821598 11.690 NM_003673
TCAP
titin-cap (telethonin)
chrX_+_103031797 11.663 PLP1
proteolipid protein 1
chr7_-_44105162 11.401 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr1_+_32050510 11.370 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_-_152086555 11.343 NM_007113
TCHH
trichohyalin
chr12_-_13103317 11.342 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr12_-_6486522 11.311 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr6_+_31913852 11.249 CFB
complement factor B
chr19_+_17326196 11.223 USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr15_+_93443418 11.206 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr4_+_124317884 11.126 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr12_-_91398744 11.061 EPYC
epiphycan
chr2_+_60983354 10.999 NM_022894
PAPOLG
poly(A) polymerase gamma
chr5_+_140474198 10.997 NM_018936
PCDHB2
protocadherin beta 2
chr3_-_187452669 10.958 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chrX_+_152990322 10.923 NM_000033
ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr1_+_15802595 10.880 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chrX_-_65859107 10.874 NM_001199687
EDA2R
ectodysplasin A2 receptor
chrX_+_103031753 10.844 NM_000533
NM_199478
PLP1

proteolipid protein 1

chrX_+_110366304 10.684 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr8_-_33424642 10.670 NM_024787
RNF122
ring finger protein 122
chr2_+_79347610 10.546 REG1A
regenerating islet-derived 1 alpha
chr12_-_57630867 10.531 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr8_-_57358511 10.527 NM_006211
PENK
proenkephalin
chr9_-_34729463 10.475 NM_001141917
FAM205A
family with sequence similarity 205, member A
chr15_-_65412175 10.468 PDCD7
programmed cell death 7
chr8_+_133879202 10.410 NM_003235
TG
thyroglobulin
chr19_+_41509825 10.329 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr6_+_101846668 10.306 GRIK2
glutamate receptor, ionotropic, kainate 2
chr10_+_118305427 10.268 NM_000936
PNLIP
pancreatic lipase
chr1_-_150587879 10.256


chr1_-_163113938 10.237 RGS5
regulator of G-protein signaling 5
chrX_+_18709044 10.207 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr5_+_54455945 10.176 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr3_-_46505077 10.161 NM_001199149
LTF
lactotransferrin
chr19_-_48823331 9.973 NM_144577
CCDC114
coiled-coil domain containing 114
chr4_-_76928601 9.866 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chrX_-_7895424 9.839 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr14_+_95078713 9.780 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr4_+_71337833 9.762 NM_152291
MUC7
mucin 7, secreted
chr8_+_22210311 9.761 PIWIL2
piwi-like 2 (Drosophila)
chr5_-_141993691 9.755 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr3_+_9834201 9.741 NM_001198793
NM_005718
ARPC4-TTLL3
ARPC4
ARPC4-TTLL3 readthrough
actin related protein 2/3 complex, subunit 4, 20kDa
chr6_+_106546736 9.741 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr10_-_104597079 9.680 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr20_-_1472004 9.571 SIRPB2
signal-regulatory protein beta 2
chr5_+_68800003 9.571 NM_001205255
OCLN
occludin
chr6_-_32977312 9.543 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr8_+_40010986 9.542 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr1_+_32043745 9.491 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_-_203320249 9.368


chr9_-_123812535 9.344 NM_001735
C5
complement component 5
chr19_-_54327428 9.340 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr2_+_233390869 9.332 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr9_+_105757592 9.317 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr4_+_40198526 9.200 NM_004310
RHOH
ras homolog gene family, member H
chr16_+_67381252 9.175 NM_001161575
LRRC36
leucine rich repeat containing 36
chr4_-_17806820 9.138 DCAF16
DDB1 and CUL4 associated factor 16
chr6_-_52628272 9.130 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr4_+_72102249 8.999 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_-_27701302 8.946 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr9_-_79520878 8.887 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr4_+_78432905 8.806 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr3_+_183903862 8.780 NM_018358
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr12_+_56732658 8.763 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr12_-_102591547 8.730 NM_002674
PMCH
pro-melanin-concentrating hormone
chr4_+_71337674 8.728 NM_001145007
MUC7
mucin 7, secreted
chr22_+_22599199 8.679 NM_007128
VPREB1
pre-B lymphocyte 1
chr1_-_216978708 8.596 NM_001243514
ESRRG
estrogen-related receptor gamma
chr8_+_128427856 8.464 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr17_-_64225496 8.331 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_-_5255712 8.292 NM_000519
HBD
hemoglobin, delta
chrX_+_50653734 8.266 NM_005448
BMP15
bone morphogenetic protein 15
chr21_-_40685418 8.245 BRWD1
bromodomain and WD repeat domain containing 1
chr19_-_41356193 8.244 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr15_+_68908878 8.225 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr5_+_180415844 8.222 NM_197975
BTNL3
butyrophilin-like 3
chr10_+_118380451 8.214 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chr4_+_74269971 8.199 NM_000477
ALB
albumin
chr10_-_62149487 8.157 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_-_119470336 8.155 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr5_+_131993864 8.149 NM_002188
IL13
interleukin 13
chr21_+_34697277 8.128 IFNAR1
interferon (alpha, beta and omega) receptor 1
chr5_+_55062712 8.128 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr6_-_31939782 8.078 NM_005510
DOM3Z
dom-3 homolog Z (C. elegans)
chr8_-_27115935 8.065 STMN4
stathmin-like 4
chr10_+_49609641 8.060 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr6_+_31583766 8.052 NM_032955
AIF1
allograft inflammatory factor 1
chr2_+_219246751 8.049 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr17_+_61562177 7.960 NM_001178057
NM_152830
ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

chr6_+_31913708 7.941 NM_001710
CFB
complement factor B
chr22_+_40297085 7.923 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr22_+_22712091 7.910 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr9_-_21077804 7.902 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr12_-_11508509 7.873 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chrX_-_104465349 7.865 NM_031274
TEX13A
testis expressed 13A
chr6_+_42123143 7.853 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr7_+_107110501 7.801 NM_005295
GPR22
G protein-coupled receptor 22
chr18_-_13915534 7.794 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr3_-_9834357 7.741 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr13_-_73356058 7.734 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr11_-_84028379 7.729 NM_001206769
DLG2
discs, large homolog 2 (Drosophila)
chr1_+_16348365 7.728 NM_001042704
NM_004070
CLCNKA

CLCNKB
chloride channel Ka

chloride channel Kb
chr6_+_29364331 7.686 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr1_-_151798552 7.651 NM_001001523
RORC
RAR-related orphan receptor C
chr17_-_39093671 7.645 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr22_+_40297183 7.574 GRAP2
GRB2-related adaptor protein 2
chr10_+_105036783 7.568 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chrX_+_49593905 7.507 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr6_+_161123224 7.497 NM_000301
NM_001168338
PLG

plasminogen

chr1_-_161279724 7.473 NM_000530
MPZ
myelin protein zero
chr5_-_64777703 7.467 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr2_+_230787195 7.463 NM_174899
FBXO36
F-box protein 36
chr20_+_47895168 7.454 ZNFX1-AS1
ZNFX1 antisense RNA 1 (non-protein coding)
chr20_-_47894570 7.370 ZNFX1
zinc finger, NFX1-type containing 1
chr7_+_129906702 7.345 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr19_+_35739778 7.312 LSR
lipolysis stimulated lipoprotein receptor
chr13_+_42712177 7.285 NM_001204505
NM_001204506
DGKH

diacylglycerol kinase, eta

chr14_+_95047730 7.284 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_-_12908141 7.271 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr12_-_120765555 7.247 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr2_+_33738941 7.211 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_80677839 7.171 NM_001007023
NM_001242502
NM_001242503
NM_013989
DIO2



deiodinase, iodothyronine, type II



chr5_-_24645084 7.153 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr19_+_41594367 7.151 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr10_-_7682741 7.136 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr21_+_34697197 7.103 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr7_+_128578246 7.100 NM_032643
IRF5
interferon regulatory factor 5
chr20_-_1472168 7.099 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr19_+_15852200 7.082 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr19_-_58067724 7.066 NM_001039654
ZNF550
zinc finger protein 550
chr3_+_52813936 7.054 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr21_-_40685697 7.049 NM_001007246
NM_018963
NM_033656
BRWD1


bromodomain and WD repeat domain containing 1


chr6_+_33043702 7.047 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.87e-14 GO:0050896 response to stimulus
2.09 1.97e-13 GO:0002376 immune system process
2.40 4.34e-12 GO:0006955 immune response
2.28 3.59e-11 GO:0006952 defense response
1.49 1.20e-10 GO:0023052 signaling
1.44 1.05e-09 GO:0051716 cellular response to stimulus
1.49 2.35e-09 GO:0007165 signal transduction
1.34 2.38e-08 GO:0032501 multicellular organismal process
2.01 4.83e-08 GO:0070887 cellular response to chemical stimulus
1.59 5.98e-08 GO:0042221 response to chemical stimulus
4.66 1.21e-07 GO:0007586 digestion
1.66 2.46e-07 GO:0007166 cell surface receptor linked signaling pathway
2.47 3.24e-07 GO:0050776 regulation of immune response
1.96 8.08e-07 GO:0009611 response to wounding
1.53 8.76e-07 GO:0006950 response to stress
2.70 1.21e-05 GO:0006954 inflammatory response
2.46 1.57e-05 GO:0045087 innate immune response
1.71 2.78e-05 GO:0010033 response to organic substance
2.92 3.39e-05 GO:0071345 cellular response to cytokine stimulus
1.97 6.01e-05 GO:0002682 regulation of immune system process
2.54 7.44e-05 GO:0034097 response to cytokine stimulus
2.96 1.13e-04 GO:0019221 cytokine-mediated signaling pathway
1.52 2.25e-04 GO:0048583 regulation of response to stimulus
1.48 2.40e-04 GO:0065008 regulation of biological quality
2.04 3.94e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
2.18 9.25e-04 GO:0051707 response to other organism
1.52 9.36e-04 GO:0003008 system process
2.11 1.38e-03 GO:0002684 positive regulation of immune system process
2.56 1.97e-03 GO:0008202 steroid metabolic process
1.17 3.14e-03 GO:0065007 biological regulation
1.87 3.30e-03 GO:0071310 cellular response to organic substance
1.58 3.90e-03 GO:0051239 regulation of multicellular organismal process
3.73 4.66e-03 GO:0006959 humoral immune response
1.70 5.27e-03 GO:0006811 ion transport
1.77 5.62e-03 GO:0007155 cell adhesion
1.77 5.62e-03 GO:0022610 biological adhesion
1.97 6.43e-03 GO:0001775 cell activation
2.65 7.54e-03 GO:0050867 positive regulation of cell activation
1.85 7.57e-03 GO:0048878 chemical homeostasis
2.17 1.00e-02 GO:0051240 positive regulation of multicellular organismal process
2.27 1.12e-02 GO:0050778 positive regulation of immune response
3.87 1.14e-02 GO:0071346 cellular response to interferon-gamma
1.87 1.22e-02 GO:0050878 regulation of body fluid levels
1.67 1.30e-02 GO:0051704 multi-organism process
2.90 1.33e-02 GO:0006805 xenobiotic metabolic process
2.90 1.33e-02 GO:0071466 cellular response to xenobiotic stimulus
4.03 1.43e-02 GO:0072376 protein activation cascade
2.88 1.51e-02 GO:0009410 response to xenobiotic stimulus
2.59 1.68e-02 GO:0002696 positive regulation of leukocyte activation
3.96 1.75e-02 GO:0031294 lymphocyte costimulation
3.96 1.75e-02 GO:0031295 T cell costimulation
3.96 1.75e-02 GO:0060333 interferon-gamma-mediated signaling pathway
3.51 2.12e-02 GO:0034341 response to interferon-gamma
1.68 2.61e-02 GO:0048584 positive regulation of response to stimulus
1.10 2.67e-02 GO:0009987 cellular process
1.60 2.82e-02 GO:0007154 cell communication
2.29 2.98e-02 GO:0050865 regulation of cell activation
7.67 3.17e-02 GO:0015721 bile acid and bile salt transport
2.31 3.65e-02 GO:0002694 regulation of leukocyte activation
2.72 3.90e-02 GO:0002252 immune effector process
2.37 4.15e-02 GO:0051249 regulation of lymphocyte activation
2.64 4.18e-02 GO:0009615 response to virus
1.86 4.26e-02 GO:0009607 response to biotic stimulus
2.57 4.38e-02 GO:0051251 positive regulation of lymphocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.03 5.01e-24 GO:0005576 extracellular region
2.41 1.38e-19 GO:0044421 extracellular region part
1.88 2.11e-19 GO:0044459 plasma membrane part
2.21 4.30e-18 GO:0005887 integral to plasma membrane
2.57 9.84e-18 GO:0005615 extracellular space
2.17 2.54e-17 GO:0031226 intrinsic to plasma membrane
1.49 2.55e-14 GO:0071944 cell periphery
1.49 3.16e-14 GO:0005886 plasma membrane
1.68 7.07e-05 GO:0000267 cell fraction
3.18 7.87e-05 GO:0009897 external side of plasma membrane
1.20 4.94e-04 GO:0044425 membrane part
2.11 6.90e-04 GO:0009986 cell surface
1.71 7.98e-04 GO:0005626 insoluble fraction
1.72 8.75e-04 GO:0005624 membrane fraction
2.04 2.87e-03 GO:0031012 extracellular matrix
1.20 6.19e-03 GO:0031224 intrinsic to membrane
8.77 7.84e-03 GO:0042627 chylomicron
1.19 1.59e-02 GO:0016021 integral to membrane
1.14 1.96e-02 GO:0016020 membrane
2.01 2.26e-02 GO:0005578 proteinaceous extracellular matrix
7.02 3.66e-02 GO:0034706 sodium channel complex
3.71 4.58e-02 GO:0031983 vesicle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.97 3.72e-09 GO:0005102 receptor binding
2.98 7.77e-06 GO:0005125 cytokine activity
1.72 2.29e-04 GO:0022857 transmembrane transporter activity
1.67 4.73e-04 GO:0022892 substrate-specific transporter activity
2.73 6.29e-04 GO:0005126 cytokine receptor binding
4.46 8.99e-04 GO:0042562 hormone binding
1.58 1.28e-03 GO:0005215 transporter activity
4.58 3.77e-03 GO:0008009 chemokine activity
1.98 4.96e-03 GO:0015267 channel activity
1.97 5.29e-03 GO:0022803 passive transmembrane transporter activity
1.39 5.49e-03 GO:0004871 signal transducer activity
1.39 5.49e-03 GO:0060089 molecular transducer activity
1.64 5.95e-03 GO:0022891 substrate-specific transmembrane transporter activity
9.57 6.57e-03 GO:0030553 cGMP binding
4.13 1.18e-02 GO:0042379 chemokine receptor binding
8.77 1.25e-02 GO:0019002 GMP binding
1.67 1.38e-02 GO:0015075 ion transmembrane transporter activity
5.85 1.89e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
3.01 2.16e-02 GO:0005179 hormone activity
2.45 2.29e-02 GO:0001664 G-protein-coupled receptor binding
5.61 2.64e-02 GO:0004112 cyclic-nucleotide phosphodiesterase activity
1.47 3.46e-02 GO:0004888 transmembrane receptor activity
1.39 4.06e-02 GO:0004872 receptor activity