Motif ID: GFI1B.p2

Z-value: 0.997


Transcription factors associated with GFI1B.p2:

Gene SymbolEntrez IDGene Name
GFI1B 8328 growth factor independent 1B transcription repressor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GFI1Bchr9_+_135854097-0.171.1e-02Click!


Activity profile for motif GFI1B.p2.

activity profile for motif GFI1B.p2


Sorted Z-values histogram for motif GFI1B.p2

Sorted Z-values for motif GFI1B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_119737905 10.553 MCTS1
malignant T cell amplified sequence 1
chrX_+_119738542 10.192 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr5_+_134209426 10.164 NM_024715
TXNDC15
thioredoxin domain containing 15
chr22_+_22735134 8.299 CYAT1
immunoglobulin lambda light chain-like
chr7_-_56101830 7.316 PSPH
phosphoserine phosphatase
chr1_+_211500147 7.245 NM_001033910
TRAF5
TNF receptor-associated factor 5
chr1_+_211500166 6.842 TRAF5
TNF receptor-associated factor 5
chr17_+_70117168 6.811 SOX9
SRY (sex determining region Y)-box 9
chr17_-_56494930 6.624 NM_017763
RNF43
ring finger protein 43
chr10_-_91011516 6.208 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr17_+_70117177 6.157 SOX9
SRY (sex determining region Y)-box 9
chr4_-_186877869 5.842 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr3_+_142375738 5.787 NM_001172312
PLS1
plastin 1
chr1_+_211499956 5.718 NM_004619
TRAF5
TNF receptor-associated factor 5
chr9_+_97521930 5.550 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr22_+_22735207 5.549 IGLJ3
immunoglobulin lambda joining 3
chr4_-_186733372 5.451 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr10_-_91011562 5.398 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr2_+_170662044 5.219 SSB
Sjogren syndrome antigen B (autoantigen La)
chr17_-_56494889 4.763 RNF43
ring finger protein 43
chr11_+_19372270 4.741 NM_001111018
NAV2
neuron navigator 2
chr18_+_11981421 4.714 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr6_-_75965845 4.580 TMEM30A
transmembrane protein 30A
chr1_+_84647342 4.417 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chrX_+_119737984 4.364 MCTS1
malignant T cell amplified sequence 1
chr4_+_166248816 3.992 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr4_-_186877413 3.881 SORBS2
sorbin and SH3 domain containing 2
chr9_-_35103089 3.805 STOML2
stomatin (EPB72)-like 2
chr7_-_27205148 3.768 NM_152739
HOXA9
homeobox A9
chr12_+_96252770 3.728 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr1_+_27189628 3.665 NM_006142
SFN
stratifin
chr19_+_19303007 3.366 NM_003721
NM_134440
RFXANK

regulatory factor X-associated ankyrin-containing protein

chr7_-_27205123 3.351 HOXA9
homeobox A9
chr17_-_29648631 3.342 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr12_+_96252705 3.342 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr4_-_186577858 3.293 SORBS2
sorbin and SH3 domain containing 2
chr11_+_34654010 3.258 NM_001206616
EHF
ets homologous factor
chrX_+_119737743 3.258 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr1_-_33502452 3.214 AK2
adenylate kinase 2
chrX_-_10588458 3.144 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr2_-_96873938 3.077 STARD7
StAR-related lipid transfer (START) domain containing 7
chr1_-_3816704 3.072 C1orf174
chromosome 1 open reading frame 174
chr5_+_102201526 3.068 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr1_+_104097321 3.052 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr9_-_95055913 3.042 IARS
isoleucyl-tRNA synthetase
chr12_+_121132677 3.042


chr8_+_26150731 2.956 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr18_+_11981552 2.884 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr1_-_33282844 2.841 YARS
tyrosyl-tRNA synthetase
chr22_-_28315202 2.803 PITPNB
phosphatidylinositol transfer protein, beta
chrX_+_47004663 2.802 RBM10
RNA binding motif protein 10
chr13_+_28196029 2.784 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr15_+_80364902 2.774 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr6_+_43738177 2.704 VEGFA
vascular endothelial growth factor A
chrX_+_47004609 2.678 NM_001204466
NM_001204467
NM_001204468
NM_005676
NM_152856
RBM10




RNA binding motif protein 10




chr3_-_25683825 2.677 TOP2B
topoisomerase (DNA) II beta 180kDa
chrX_+_47004676 2.665 RBM10
RNA binding motif protein 10
chr6_-_32920812 2.655 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr12_+_123237302 2.620 NM_003677
DENR
density-regulated protein
chr1_+_111413820 2.600 NM_001040033
CD53
CD53 molecule
chrX_+_47004670 2.568 RBM10
RNA binding motif protein 10
chrX_+_47004657 2.552 RBM10
RNA binding motif protein 10
chr1_-_27816542 2.505 WASF2
WAS protein family, member 2
chr4_+_154125589 2.492 NM_015271
TRIM2
tripartite motif containing 2
chr6_+_87969619 2.465 ZNF292
zinc finger protein 292
chrX_+_47004665 2.439 RBM10
RNA binding motif protein 10
chr9_-_95055966 2.384 NM_013417
IARS
isoleucyl-tRNA synthetase
chrX_+_77154956 2.379 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr10_+_104535887 2.366 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr3_-_128902672 2.354 CNBP
CCHC-type zinc finger, nucleic acid binding protein
chrX_+_47004633 2.285 RBM10
RNA binding motif protein 10
chr12_+_54674531 2.280 HNRNPA1L2
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1-like 2
heterogeneous nuclear ribonucleoprotein A1
chr16_+_2807490 2.257


chr9_-_95055986 2.239 IARS
isoleucyl-tRNA synthetase
chr11_+_5710926 2.152 TRIM22
tripartite motif containing 22
chr8_+_9953061 2.148 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chr5_+_137203559 2.140 MYOT
myotilin
chr1_-_23886284 2.106 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr6_+_43738394 2.074 VEGFA
vascular endothelial growth factor A
chr13_+_28196024 2.073 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr22_-_28315214 2.062 NM_012399
PITPNB
phosphatidylinositol transfer protein, beta
chrX_+_47004619 2.053 RBM10
RNA binding motif protein 10
chr1_+_101702304 2.030 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr22_+_22735202 2.019


chr15_+_66694216 1.912 MAP2K1
mitogen-activated protein kinase kinase 1
chr21_-_27512668 1.912 NM_001136016
APP
amyloid beta (A4) precursor protein
chr5_+_137203544 1.885 NM_001135940
NM_006790
MYOT

myotilin

chr18_+_3451589 1.880 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr19_-_13227212 1.861 NM_001142554
NM_017722
NM_001136035
TRMT1


TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)


chr14_-_75600111 1.852 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_-_96874507 1.835 STARD7
StAR-related lipid transfer (START) domain containing 7
chr6_+_160211482 1.824 NM_014161
MRPL18
mitochondrial ribosomal protein L18
chr19_+_41770285 1.812 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr13_+_28196004 1.800 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr12_+_64803741 1.786 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr9_-_35103048 1.777 STOML2
stomatin (EPB72)-like 2
chr3_+_100053544 1.750 NM_020202
NIT2
nitrilase family, member 2
chr2_+_85843286 1.740 USP39
ubiquitin specific peptidase 39
chr12_+_54674478 1.736 NM_002136
NM_031157
HNRNPA1

heterogeneous nuclear ribonucleoprotein A1

chr17_-_79894967 1.732 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr19_-_14247400 1.727 NM_018154
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr5_+_31532372 1.710 NM_018356
C5orf22
chromosome 5 open reading frame 22
chr17_-_79995555 1.673 NM_001195218
NM_016286
DCXR

dicarbonyl/L-xylulose reductase

chrX_+_154444700 1.664 NM_003372
VBP1
von Hippel-Lindau binding protein 1
chr9_+_33624214 1.654 ANXA2P2
annexin A2 pseudogene 2
chr3_-_18480203 1.587 NM_001131010
SATB1
SATB homeobox 1
chr19_+_41770329 1.577 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr14_-_50583194 1.561 NM_001040662
NM_024558
METTL21D

methyltransferase like 21D

chr4_-_186578122 1.543 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr6_+_32709162 1.515 NM_020056
HLA-DQA1
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 2
chr22_-_43036606 1.478 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr10_-_91011586 1.473 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr8_+_6566153 1.459 AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chrX_+_46696346 1.449 NM_006915
RP2
retinitis pigmentosa 2 (X-linked recessive)
chrX_+_49832214 1.442 NM_000084
CLCN5
chloride channel 5
chr1_-_156308047 1.441 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr12_+_117348710 1.434 NM_012174
NM_153348
FBXW8

F-box and WD repeat domain containing 8

chr9_-_86584079 1.414 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr1_+_110560111 1.413 AHCYL1
adenosylhomocysteinase-like 1
chr4_-_151770611 1.405 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr18_-_24445652 1.396 NM_001650
AQP4
aquaporin 4
chr5_-_88179278 1.326 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr1_-_3816823 1.308 NM_207356
C1orf174
chromosome 1 open reading frame 174
chr12_-_28124915 1.300 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr1_-_156307971 1.292 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr12_-_7818467 1.283 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr1_+_26872306 1.277 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chrX_+_46696424 1.265 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr4_+_1283662 1.249 NM_001017405
NM_005882
MAEA

macrophage erythroblast attacher

chr3_+_172468469 1.214 ECT2
epithelial cell transforming sequence 2 oncogene
chr3_+_113775658 1.207 QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr14_-_107078578 1.200


chr5_-_31532164 1.195 NM_001100412
NM_013235
DROSHA

drosha, ribonuclease type III

chr2_+_85843280 1.193 NM_006590
USP39
ubiquitin specific peptidase 39
chr1_+_84630575 1.174 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr2_+_163200582 1.171 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr5_+_109025135 1.167 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr8_-_19540093 1.147 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr18_+_33234532 1.141 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr19_+_41770349 1.140 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr11_-_58343308 1.134 NM_004811
LPXN
leupaxin
chr14_+_23789396 1.132 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr2_+_85843307 1.132 USP39
ubiquitin specific peptidase 39
chr5_+_43609261 1.123 NNT
nicotinamide nucleotide transhydrogenase
chrX_+_47004693 1.121 RBM10
RNA binding motif protein 10
chr21_-_46237966 1.092 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr10_-_129924467 1.091 NM_001145966
NM_002417
MKI67

antigen identified by monoclonal antibody Ki-67

chr19_-_51858041 1.090 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr1_+_218518675 1.086 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr22_-_24096551 1.076 NM_013378
VPREB3
pre-B lymphocyte 3
chr2_+_85843247 1.065 USP39
ubiquitin specific peptidase 39
chr1_+_158979681 1.053 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr5_-_7869113 1.052 NM_024091
FASTKD3
FAST kinase domains 3
chrX_+_147800610 1.049 NM_001170628
AFF2
AF4/FMR2 family, member 2
chr1_-_167059524 1.037 NM_005814
GPA33
glycoprotein A33 (transmembrane)
chr10_+_69644341 1.036 NM_012238
SIRT1
sirtuin 1
chr1_+_66798095 1.025 PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_156308064 1.004 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr2_+_183582667 1.004 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr12_+_69742130 0.991 NM_000239
LYZ
lysozyme
chr5_-_88119604 0.988 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr21_-_46237882 0.983 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr9_+_12693385 0.982 NM_000550
TYRP1
tyrosinase-related protein 1
chr1_+_24840800 0.971 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr2_+_109223600 0.961 NM_001193482
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_28475233 0.958 NM_004904
CREB5
cAMP responsive element binding protein 5
chr4_-_47465719 0.944 COMMD8
COMM domain containing 8
chr9_-_95055989 0.939 NM_002161
IARS
isoleucyl-tRNA synthetase
chr15_-_37391596 0.927 NM_172316
MEIS2
Meis homeobox 2
chr17_+_27046990 0.927 NM_000984
RPL23A
ribosomal protein L23a
chr2_-_20512016 0.923 PUM2
pumilio homolog 2 (Drosophila)
chr2_+_85843315 0.891 USP39
ubiquitin specific peptidase 39
chr3_-_187452669 0.888 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr16_-_30441300 0.876 NM_024096
DCTPP1
dCTP pyrophosphatase 1
chr1_-_6420719 0.867 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr9_-_91793681 0.866 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr16_-_4896197 0.849 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr2_-_61765367 0.848 XPO1
exportin 1 (CRM1 homolog, yeast)
chr17_-_76183074 0.835 NM_003258
TK1
thymidine kinase 1, soluble
chr3_-_128902764 0.831 NM_001127192
NM_001127193
NM_001127194
NM_001127195
NM_001127196
NM_003418
CNBP





CCHC-type zinc finger, nucleic acid binding protein





chr2_-_130886794 0.823 NM_001099771
POTEF
POTE ankyrin domain family, member F
chr15_-_68498373 0.822 NM_001031733
NM_033429
CALML4

calmodulin-like 4

chr2_+_65216526 0.819 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr17_+_5389715 0.815 MIS12
MIS12, MIND kinetochore complex component, homolog (S. pombe)
chr15_+_57511616 0.815 NM_207040
TCF12
transcription factor 12
chr3_+_169492051 0.809 NM_001185119
MYNN
myoneurin
chr14_-_68162419 0.806 NM_001252650
NM_016026
RDH11

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

chr3_-_187454247 0.806 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr1_-_220219874 0.802 NM_004446
EPRS
glutamyl-prolyl-tRNA synthetase
chr3_-_12705626 0.801 NM_002880
RAF1
v-raf-1 murine leukemia viral oncogene homolog 1
chr11_+_62529049 0.800 POLR2G
polymerase (RNA) II (DNA directed) polypeptide G
chr19_-_14530155 0.799 NM_005804
DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr8_-_18666295 0.789 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr2_-_61765394 0.789 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr6_+_12290528 0.786 NM_001168319
NM_001955
EDN1

endothelin 1

chr11_+_62529010 0.784 NM_002696
POLR2G
polymerase (RNA) II (DNA directed) polypeptide G
chr12_-_121790165 0.776 ANAPC5
anaphase promoting complex subunit 5
chr11_+_118764100 0.762 NM_032966
CXCR5
chemokine (C-X-C motif) receptor 5
chr5_+_102201713 0.755 PAM
peptidylglycine alpha-amidating monooxygenase
chr3_-_12705329 0.752 RAF1
v-raf-1 murine leukemia viral oncogene homolog 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 1.84e-08 GO:0009987 cellular process
1.50 1.69e-07 GO:0044237 cellular metabolic process
1.96 1.90e-07 GO:0009058 biosynthetic process
1.93 1.41e-06 GO:0044249 cellular biosynthetic process
1.39 1.29e-05 GO:0008152 metabolic process
1.43 2.32e-05 GO:0044238 primary metabolic process
1.67 1.46e-04 GO:0034641 cellular nitrogen compound metabolic process
1.93 1.94e-04 GO:0010467 gene expression
1.65 1.98e-04 GO:0006807 nitrogen compound metabolic process
1.97 2.16e-04 GO:0016070 RNA metabolic process
1.91 5.11e-04 GO:0044281 small molecule metabolic process
1.92 9.74e-04 GO:0009059 macromolecule biosynthetic process
1.49 1.26e-03 GO:0044260 cellular macromolecule metabolic process
1.67 1.40e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.92 1.44e-03 GO:0034645 cellular macromolecule biosynthetic process
1.55 3.08e-03 GO:0071840 cellular component organization or biogenesis
2.76 5.09e-03 GO:0044283 small molecule biosynthetic process
1.40 1.14e-02 GO:0043170 macromolecule metabolic process
1.69 1.28e-02 GO:0090304 nucleic acid metabolic process
1.53 1.40e-02 GO:0016043 cellular component organization
1.28 1.41e-02 GO:0065007 biological regulation
2.10 2.00e-02 GO:0032774 RNA biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 1.78e-13 GO:0044424 intracellular part
1.29 9.99e-13 GO:0005622 intracellular
1.50 2.20e-07 GO:0044422 organelle part
1.51 2.68e-07 GO:0044446 intracellular organelle part
1.34 1.03e-06 GO:0005737 cytoplasm
1.27 3.52e-06 GO:0043229 intracellular organelle
1.27 4.31e-06 GO:0043226 organelle
1.28 5.20e-05 GO:0043231 intracellular membrane-bounded organelle
1.28 5.78e-05 GO:0043227 membrane-bounded organelle
1.40 7.95e-05 GO:0044444 cytoplasmic part
2.01 3.94e-04 GO:0005654 nucleoplasm
1.69 9.66e-04 GO:0031974 membrane-enclosed lumen
1.69 1.03e-03 GO:0043233 organelle lumen
1.71 1.89e-03 GO:0005829 cytosol
1.09 2.67e-03 GO:0044464 cell part
1.09 2.70e-03 GO:0005623 cell
1.67 3.47e-03 GO:0044428 nuclear part
1.74 3.53e-03 GO:0031981 nuclear lumen
1.61 1.22e-02 GO:0070013 intracellular organelle lumen
1.43 2.62e-02 GO:0032991 macromolecular complex
2.43 3.54e-02 GO:0044427 chromosomal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.43 1.10e-04 GO:0003723 RNA binding
1.32 2.54e-04 GO:0005515 protein binding