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Motif ID: HAND1,2.p2

Z-value: 2.970

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr5_-_149792370	66.726	NM_001025158 NM_001025159 NM_004355	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_-_37701385	54.330	NM_152279	ZNF585B	zinc finger protein 585B
chr5_-_149792276	52.404		CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr14_-_107179043	52.365		IGHA1	immunoglobulin heavy constant alpha 1
chr22_+_22723972	49.381
chr22_+_23213671	47.061		IGLV4-3	immunoglobulin lambda variable 4-3
chr19_-_9695166	43.532	NM_001008727	ZNF121	zinc finger protein 121
chr1_-_155904201	43.308		KIAA0907	KIAA0907
chrX_+_128913881	43.223	NM_018990	SASH3	SAM and SH3 domain containing 3
chr11_+_71927818	37.976	NM_000803 NM_001113534 NM_001113535 NM_001113536	FOLR2	folate receptor 2 (fetal)
chrX_+_128913897	37.425		SASH3	SAM and SH3 domain containing 3
chr3_-_195310985	37.392	NM_001647	APOD	apolipoprotein D
chr18_+_21572736	36.141	NM_153211	TTC39C	tetratricopeptide repeat domain 39C
chr19_+_507475	33.730	NM_033513	TPGS1	tubulin polyglutamylase complex subunit 1
chr7_+_142560512	31.217		EPHB6	EPH receptor B6
chr6_+_6588933	29.726	NM_004271	LY86	lymphocyte antigen 86
chr3_-_20227618	28.854	NM_001012409 NM_001012410 NM_001012411 NM_001012412 NM_001012413 NM_138484 NM_001199251 NM_001199252 NM_001199253 NM_001199254 NM_001199255 NM_001199256 NM_001199257	SGOL1	shugoshin-like 1 (S. pombe)
chr14_-_106208537	28.825
chr3_-_195310770	28.683		APOD	apolipoprotein D
chr14_-_107013474	27.671		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr21_-_46340821	27.316		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_17186569	26.642	NM_001130065 NM_004145	MYO9B	myosin IXB
chr5_+_36608430	26.279	NM_001166695	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_112194648	26.067	NM_002037	FYN	FYN oncogene related to SRC, FGR, YES
chr6_-_112194430	26.054		FYN	FYN oncogene related to SRC, FGR, YES
chr9_-_72873739	25.443		LOC100507299	uncharacterized LOC100507299
chr17_+_53342356	25.360		HLF	hepatic leukemia factor
chr1_+_22979681	24.093	NM_000491	C1QB	complement component 1, q subcomponent, B chain
chr2_+_113816684	24.028	NM_012275	IL36RN	interleukin 36 receptor antagonist
chr11_+_2323236	23.752	NM_139022	TSPAN32	tetraspanin 32
chr18_-_53068755	23.200		TCF4	transcription factor 4
chr3_+_133494275	22.877		TF	transferrin
chr14_-_24777153	22.426		CIDEB	cell death-inducing DFFA-like effector b
chr11_+_2323356	22.313		TSPAN32	tetraspanin 32
chrX_+_70364707	21.691		NLGN3	neuroligin 3
chr14_+_21359542	21.064	NM_002935	RNASE3	ribonuclease, RNase A family, 3
chr22_+_41957011	20.569	NM_014460	CSDC2	cold shock domain containing C2, RNA binding
chr21_+_27012045	20.471		JAM2	junctional adhesion molecule 2
chr2_-_27718098	20.334	NM_022823	FNDC4	fibronectin type III domain containing 4
chr14_-_24777064	20.067
chr1_+_26644458	20.024		CD52	CD52 molecule
chr2_+_219246751	19.947	NM_000578	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chrX_+_70364728	19.702		NLGN3	neuroligin 3
chr20_-_1165116	19.397	NM_018354	TMEM74B	transmembrane protein 74B
chr13_+_31309690	19.219		ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr1_-_160681552	18.973	NM_001778	CD48	CD48 molecule
chr15_+_68908878	18.971	NM_001190456	CORO2B	coronin, actin binding protein, 2B
chrX_+_70364680	18.504	NM_001166660 NM_018977 NM_181303	NLGN3	neuroligin 3
chr14_-_24423329	18.296		C14orf167	chromosome 14 open reading frame 167
chr22_+_24999113	18.205	NM_001032364 NM_005265	GGT1	gamma-glutamyltransferase 1
chr19_+_50016500	17.959		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr16_+_29674564	17.863		SPN	sialophorin
chr8_+_21916858	17.836		EPB49	erythrocyte membrane protein band 4.9 (dematin)
chr7_+_99816870	17.367	NM_024070	PVRIG	poliovirus receptor related immunoglobulin domain containing
chr11_-_63330854	16.956	NM_017878	HRASLS2	HRAS-like suppressor 2
chr12_+_49688908	16.929	NM_006262	PRPH	peripherin
chr22_-_36556781	16.866	NM_145640	APOL3	apolipoprotein L, 3
chr11_+_46722316	16.830	NM_024741	ZNF408	zinc finger protein 408
chr22_+_23063107	16.793		IGLJ3	immunoglobulin lambda joining 3
chr10_-_90712510	16.623	NM_001613	ACTA2	actin, alpha 2, smooth muscle, aorta
chr2_-_27718059	16.454		FNDC4	fibronectin type III domain containing 4
chr14_-_107078578	16.319
chr5_+_36606456	16.148	NM_001166696 NM_004172	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_228497801	16.099	NM_001162483 NM_020161	C2orf83	chromosome 2 open reading frame 83
chr4_-_174320616	15.839	NM_007281	SCRG1	stimulator of chondrogenesis 1
chr12_-_57630867	15.596		NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr6_+_134210247	15.569	NM_198392 NM_003206	TCF21	transcription factor 21
chr1_-_156399183	15.537	NM_006365	C1orf61	chromosome 1 open reading frame 61
chr1_+_26644380	15.529	NM_001803	CD52	CD52 molecule
chr17_+_40913233	15.529		RAMP2	receptor (G protein-coupled) activity modifying protein 2
chr14_-_24777160	15.518		CIDEB	cell death-inducing DFFA-like effector b
chr11_+_121461070	15.490		SORL1	sortilin-related receptor, L(DLR class) A repeats containing
chr5_+_150399980	15.395	NM_002084	GPX3	glutathione peroxidase 3 (plasma)
chr3_-_39321479	15.284	NM_001337	CX3CR1	chemokine (C-X3-C motif) receptor 1
chr11_-_5271035	15.254	NM_000559	HBG1	hemoglobin, gamma A
chrX_+_103031433	15.230	NM_001128834	PLP1	proteolipid protein 1
chrY_+_1405508	15.210	NM_002183	IL3RA	interleukin 3 receptor, alpha (low affinity)
chr12_-_53600999	15.155	NM_000889	ITGB7	integrin, beta 7
chr16_+_6069094	15.124	NM_001142333 NM_018723	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1
chrX_+_1455508	14.999	NM_002183	IL3RA	interleukin 3 receptor, alpha (low affinity)
chr1_+_156123321	14.954	NM_001193300 NM_022367 NM_001193302	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr5_+_36606667	14.851		SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_4455285	14.794	NM_001171091	UBXN6	UBX domain protein 6
chr14_-_106774311	14.771		IGHA1	immunoglobulin heavy constant alpha 1
chr6_+_33043702	14.616	NM_002121	HLA-DPB1	major histocompatibility complex, class II, DP beta 1
chr2_+_3642421	14.461	NM_024027 NM_199235	COLEC11	collectin sub-family member 11
chr11_-_2158510	14.301		IGF2	insulin-like growth factor 2 (somatomedin A)
chr11_+_118827007	14.197	NM_006760	UPK2	uroplakin 2
chr16_-_89556886	14.187	NM_013275	ANKRD11	ankyrin repeat domain 11
chr12_-_110271182	14.113		TRPV4	transient receptor potential cation channel, subfamily V, member 4
chr22_+_51176623	13.957	NM_001097	ACR	acrosin
chr6_+_134210264	13.920		TCF21	transcription factor 21
chr12_-_7245048	13.877		C1R	complement component 1, r subcomponent
chr14_-_106111114	13.856		IGHG2	immunoglobulin heavy constant gamma 2 (G2m marker)
chr2_-_31637553	13.805		XDH	xanthine dehydrogenase
chr19_-_8642297	13.771		MYO1F	myosin IF
chr15_+_74422742	13.762	NM_020851	ISLR2	immunoglobulin superfamily containing leucine-rich repeat 2
chr14_-_106746056	13.720
chrX_+_69672356	13.647		DLG3	discs, large homolog 3 (Drosophila)
chr21_-_46340776	13.538		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr9_+_125137600	13.519		PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_+_148415657	13.480	NM_000685 NM_004835 NM_009585 NM_031850	AGTR1	angiotensin II receptor, type 1
chr6_-_46889620	13.445	NM_001098518	GPR116	G protein-coupled receptor 116
chr2_+_97202463	13.379	NM_212481	ARID5A	AT rich interactive domain 5A (MRF1-like)
chr9_+_124086842	13.360		GSN	gelsolin
chr1_-_59012379	13.258	NM_145243	OMA1	OMA1 zinc metallopeptidase homolog (S. cerevisiae)
chrX_+_103031797	13.154		PLP1	proteolipid protein 1
chr16_-_20587625	13.122	NM_001105069 NM_182617	ACSM2B	acyl-CoA synthetase medium-chain family member 2B
chr19_-_42931500	13.115	NM_005357	LIPE	lipase, hormone-sensitive
chr13_+_31309644	13.092	NM_001629	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr15_-_29862926	12.881	NM_015307	FAM189A1	family with sequence similarity 189, member A1
chr11_-_64527369	12.757		PYGM	phosphorylase, glycogen, muscle
chrX_-_32173585	12.752	NM_004013 NM_004020 NM_004021 NM_004022 NM_004023	DMD	dystrophin
chr19_+_36359346	12.751	NM_001024807 NM_005166	APLP1	amyloid beta (A4) precursor-like protein 1
chr19_-_8642337	12.527		MYO1F	myosin IF
chr1_+_36772696	12.487	NM_024676	SH3D21	SH3 domain containing 21
chr6_-_46922533	12.455	NM_015234	GPR116	G protein-coupled receptor 116
chr11_-_2323066	12.334	NM_001142946	C11orf21	chromosome 11 open reading frame 21
chr3_+_123813527	12.247	NM_001024660 NM_003947	KALRN	kalirin, RhoGEF kinase
chr16_+_20462858	12.166	NM_001010845	ACSM2A	acyl-CoA synthetase medium-chain family member 2A
chr14_-_106092256	12.143		IGHG4	immunoglobulin heavy constant gamma 4 (G4m marker)
chr12_+_41086189	12.040	NM_001843 NM_175038	CNTN1	contactin 1
chr12_-_7245006	11.991	NM_001733	C1R	complement component 1, r subcomponent
chr10_-_99531712	11.904	NM_003015	SFRP5	secreted frizzled-related protein 5
chr8_-_19540093	11.825	NM_018371	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr12_+_54891539	11.790		NCKAP1L	NCK-associated protein 1-like
chr13_-_46742678	11.775		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_8642309	11.597	NM_012335	MYO1F	myosin IF
chr11_+_71903172	11.550	NM_016729	FOLR1	folate receptor 1 (adult)
chr17_+_40913211	11.519	NM_005854	RAMP2	receptor (G protein-coupled) activity modifying protein 2
chrY_+_15016018	11.515	NM_001122665	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr16_+_28505920	11.510	NM_018690	APOBR	apolipoprotein B receptor
chr17_+_14204326	11.492	NM_006041	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr19_-_36304200	11.467	NM_021232	PRODH2	proline dehydrogenase (oxidase) 2
chr3_+_195447751	11.284	NM_152673	MUC20	mucin 20, cell surface associated
chr12_-_110271205	11.152	NM_021625	TRPV4	transient receptor potential cation channel, subfamily V, member 4
chr5_-_41261539	11.132	NM_001115131	C6	complement component 6
chr2_-_89513056	11.051		IGKC	immunoglobulin kappa constant
chr11_-_119999516	11.030		TRIM29	tripartite motif containing 29
chr11_+_60197061	10.967	NM_023945	MS4A5	membrane-spanning 4-domains, subfamily A, member 5
chr17_-_42345434	10.966	NM_000342	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr14_-_106209380	10.961		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_-_94953827	10.895	NM_000446	PON1	paraoxonase 1
chrX_-_55057408	10.868	NM_000032 NM_001037967 NM_001037968	ALAS2	aminolevulinate, delta-, synthase 2
chr1_+_150245182	10.857	NM_024579	C1orf54	chromosome 1 open reading frame 54
chr17_+_53342320	10.812	NM_002126	HLF	hepatic leukemia factor
chr1_-_167883243	10.591	NM_001167749 NM_018417	ADCY10	adenylate cyclase 10 (soluble)
chr9_-_4742042	10.565	NM_001199853	AK3	adenylate kinase 3
chr11_-_57004674	10.510	NM_005161	APLNR	apelin receptor
chr10_-_71176567	10.509	NM_001057	TACR2	tachykinin receptor 2
chr15_-_43513024	10.448		EPB42	erythrocyte membrane protein band 4.2
chr14_-_106237675	10.439		IGHM	immunoglobulin heavy constant mu
chr19_+_55587220	10.404	NM_133180	EPS8L1	EPS8-like 1
chr17_-_56358161	10.341		MPO	myeloperoxidase
chr19_-_54850385	10.331	NM_012276	LILRA4	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr3_+_112052020	10.295		CD200	CD200 molecule
chr2_+_238475216	10.287	NM_015893	PRLH	prolactin releasing hormone
chr14_-_107170400	10.227		IGHV4-31 IGHV1-69 IGHA1 IGHG1 IGHG3 IGHM	immunoglobulin heavy variable 4-31 immunoglobulin heavy variable 1-69 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu
chr2_-_25474948	10.226	NM_153759	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha
chr22_+_22712091	10.178		IGLV1-44 IGL@	immunoglobulin lambda variable 1-44 immunoglobulin lambda locus
chr1_-_201081693	10.146	NM_000069	CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit
chr1_-_160549226	10.118		CD84	CD84 molecule
chr12_-_53601051	10.079		ITGB7	integrin, beta 7
chr10_-_75401492	9.870	NM_021245	MYOZ1	myozenin 1
chr5_-_137071462	9.826		KLHL3	kelch-like 3 (Drosophila)
chr2_+_189839132	9.820		COL3A1	collagen, type III, alpha 1
chr11_-_55703875	9.771	NM_006637	OR5I1	olfactory receptor, family 5, subfamily I, member 1
chr20_-_43883183	9.756	NM_003064	SLPI	secretory leukocyte peptidase inhibitor
chr8_-_86290333	9.715	NM_001128829 NM_001128830 NM_001128831 NM_001738	CA1	carbonic anhydrase I
chr22_+_25003610	9.664	NM_001032365	GGT1	gamma-glutamyltransferase 1
chr11_-_89650877	9.421	NM_001206627	LOC399939	ring finger protein 18-like
chr15_-_43513234	9.381	NM_000119 NM_001114134	EPB42	erythrocyte membrane protein band 4.2
chr14_-_106471439	9.348		IGHA1 IGHG1 IGHM	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant mu
chr16_-_31146992	9.301		PRSS8	protease, serine, 8
chr18_+_29171729	9.273	NM_000371	TTR	transthyretin
chr2_+_169921298	9.229	NM_005771	DHRS9	dehydrogenase/reductase (SDR family) member 9
chr9_-_4741798	9.209	NM_001199855	AK3	adenylate kinase 3
chr3_+_9834201	9.209	NM_001198793 NM_005718	ARPC4-TTLL3 ARPC4	ARPC4-TTLL3 readthrough actin related protein 2/3 complex, subunit 4, 20kDa
chr22_+_38004454	9.192	NM_001001560 NM_001001561 NM_001172687 NM_013365	GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr14_-_106405633	9.173		IGHM	immunoglobulin heavy constant mu
chr19_+_50936159	9.107	NM_004533	MYBPC2	myosin binding protein C, fast type
chr1_+_92632608	9.099	NM_015237	KIAA1107	KIAA1107
chr2_+_113763448	9.002	NM_014440	IL36A	interleukin 36, alpha
chr19_-_48614013	8.933	NM_001159322 NM_001159323 NM_003706	PLA2G4C	phospholipase A2, group IVC (cytosolic, calcium-independent)
chrX_-_13338517	8.910	NM_001135995	ATXN3L	ataxin 3-like
chr2_+_113875469	8.900	NM_000577 NM_173841 NM_173843	IL1RN	interleukin 1 receptor antagonist
chr15_+_74421986	8.890	NM_001130137	ISLR2	immunoglobulin superfamily containing leucine-rich repeat 2
chr7_+_110731061	8.820	NM_001099658 NM_001099660 NM_018334	LRRN3	leucine rich repeat neuronal 3
chr7_-_143966380	8.803	NM_198495	CTAGE4 CTAGE8	CTAGE family, member 4 CTAGE family, member 8
chr3_+_108015392	8.800		HHLA2	HERV-H LTR-associating 2
chr16_+_57438678	8.761	NM_002987	CCL17	chemokine (C-C motif) ligand 17
chr7_+_143880547	8.748	NM_198495	CTAGE4 CTAGE8	CTAGE family, member 4 CTAGE family, member 8
chr4_+_74281884	8.737		ALB	albumin
chr17_-_38074842	8.714	NM_001042471 NM_001165958 NM_001165959	GSDMB	gasdermin B
chr3_+_112051914	8.698	NM_001004196 NM_005944	CD200	CD200 molecule
chr16_-_20338808	8.686	NM_001007240 NM_001007241 NM_001007242 NM_001502	GP2	glycoprotein 2 (zymogen granule membrane)
chr1_-_173446273	8.682		LOC100506023	uncharacterized LOC100506023
chr21_-_46340874	8.593	NM_000211	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_26485510	8.577	NM_024869	FAM110D	family with sequence similarity 110, member D
chr6_-_161087406	8.567	NM_005577	LPA	lipoprotein, Lp(a)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.40	4.58e-05	GO:0023052	signaling
2.39	6.22e-05	GO:0050776	regulation of immune response
3.44	6.73e-05	GO:0006936	muscle contraction
3.29	1.02e-04	GO:0003012	muscle system process
1.95	4.76e-04	GO:0007267	cell-cell signaling
1.29	5.41e-04	GO:0032501	multicellular organismal process
1.24	1.41e-03	GO:0050896	response to stimulus
1.77	1.45e-03	GO:0007154	cell communication
1.91	1.71e-03	GO:0006955	immune response
1.53	1.98e-03	GO:0048583	regulation of response to stimulus
1.67	2.24e-03	GO:0002376	immune system process
1.19	2.63e-03	GO:0065007	biological regulation
2.58	1.33e-02	GO:0008202	steroid metabolic process
1.29	1.39e-02	GO:0051716	cellular response to stimulus
10.46	1.80e-02	GO:0001516	prostaglandin biosynthetic process
10.46	1.80e-02	GO:0046457	prostanoid biosynthetic process
1.70	1.91e-02	GO:0006629	lipid metabolic process
1.33	2.11e-02	GO:0007165	signal transduction
8.14	2.37e-02	GO:0006693	prostaglandin metabolic process
1.83	2.61e-02	GO:0002682	regulation of immune system process
6.70	2.93e-02	GO:0006692	prostanoid metabolic process
4.70	3.26e-02	GO:0006690	icosanoid metabolic process
2.05	4.03e-02	GO:0007268	synaptic transmission
1.42	4.19e-02	GO:0065008	regulation of biological quality
5.54	4.73e-02	GO:0046456	icosanoid biosynthetic process
3.66	4.95e-02	GO:0006959	humoral immune response

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.85	1.26e-13	GO:0005576	extracellular region
1.81	3.15e-13	GO:0044459	plasma membrane part
2.04	4.77e-11	GO:0005887	integral to plasma membrane
2.01	1.68e-10	GO:0031226	intrinsic to plasma membrane
2.28	8.68e-10	GO:0005615	extracellular space
1.46	8.88e-10	GO:0005886	plasma membrane
1.45	1.58e-09	GO:0071944	cell periphery
2.05	3.86e-09	GO:0044421	extracellular region part
1.80	1.40e-05	GO:0000267	cell fraction
1.78	1.09e-03	GO:0005626	insoluble fraction
1.78	1.44e-03	GO:0005624	membrane fraction
1.18	2.85e-03	GO:0016020	membrane
2.27	5.84e-03	GO:0015629	actin cytoskeleton
1.20	5.94e-03	GO:0044425	membrane part
2.01	2.31e-02	GO:0009986	cell surface
6.98	4.14e-02	GO:0032982	myosin filament

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
5.58	4.27e-04	GO:0019825	oxygen binding
5.76	8.76e-04	GO:0003823	antigen binding
1.43	5.64e-03	GO:0004871	signal transducer activity
1.43	5.64e-03	GO:0060089	molecular transducer activity
1.49	5.72e-03	GO:0004872	receptor activity
2.12	6.72e-03	GO:0030246	carbohydrate binding
2.91	8.35e-03	GO:0004252	serine-type endopeptidase activity
2.53	1.94e-02	GO:0005529	sugar binding
2.63	2.37e-02	GO:0008236	serine-type peptidase activity
2.59	3.08e-02	GO:0017171	serine hydrolase activity
3.17	3.36e-02	GO:0005179	hormone activity
2.01	4.64e-02	GO:0004175	endopeptidase activity