Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 2.060


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SSRP1chr11_-_57103324-0.756.9e-41Click!
HMGB3chrX_+_150151757-0.681.9e-30Click!
HMGB2chr4_-_174255454-0.621.9e-24Click!
UBTFchr17_-_42296865-0.313.3e-06Click!
HBP1chr7_+_1068094050.269.6e-05Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_52988916 48.464 NM_001243234
NM_001243235
TCF4

transcription factor 4

chrX_-_13835187 40.991 GPM6B
glycoprotein M6B
chr12_-_16757944 38.471 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_89790412 37.966 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr6_+_89790464 35.709 PNRC1
proline-rich nuclear receptor coactivator 1
chrX_-_13835012 34.599 GPM6B
glycoprotein M6B
chrX_-_13835213 33.494 GPM6B
glycoprotein M6B
chr17_+_36861398 33.484 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_+_57365577 31.555 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr18_-_53177999 31.139 NM_001243231
TCF4
transcription factor 4
chrX_-_13835313 29.596 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr12_-_91573264 29.182 NM_133503
DCN
decorin
chr11_+_57365026 29.048 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_39509069 27.570 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr6_+_99872769 27.535


chr14_-_92413738 27.471 FBLN5
fibulin 5
chr12_-_91576579 26.889 DCN
decorin
chr18_-_53071225 26.623 NM_001243232
TCF4
transcription factor 4
chr2_+_149633173 26.020


chr12_-_16760935 25.942 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr11_+_112831968 25.640 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr10_+_70847857 25.591 SRGN
serglycin
chr12_-_9268440 25.417 A2M
alpha-2-macroglobulin
chrX_+_135251795 25.208 NM_001167819
FHL1
four and a half LIM domains 1
chr18_-_53257033 24.299 NM_001243227
NM_001243228
TCF4

transcription factor 4

chr10_+_70847817 23.923 NM_002727
SRGN
serglycin
chr12_-_9268513 23.747 A2M
alpha-2-macroglobulin
chr18_+_72922725 23.675 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr1_+_36748164 23.378 THRAP3
thyroid hormone receptor associated protein 3
chr4_-_88450243 23.293 SPARCL1
SPARC-like 1 (hevin)
chr3_-_114790221 22.991 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr16_-_30934437 22.399 FBXL19-AS1
FBXL19 antisense RNA 1 (non-protein coding)
chr7_-_111846384 22.260 NM_014705
DOCK4
dedicator of cytokinesis 4
chr4_-_186877413 21.518 SORBS2
sorbin and SH3 domain containing 2
chrX_+_135251454 21.342 NM_001159704
FHL1
four and a half LIM domains 1
chr19_-_17375522 21.126 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr12_-_16758839 21.080 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759430 21.044 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_88450601 20.880 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr14_-_92414004 20.578 NM_006329
FBLN5
fibulin 5
chrX_+_64708614 20.073 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr4_+_110749149 20.030 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr11_-_111782447 19.079 NM_001885
CRYAB
crystallin, alpha B
chr12_-_16758312 19.009 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_+_45971249 19.006 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr12_-_16759531 18.626 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_32163890 18.565 NOTCH4
notch 4
chr18_-_74729049 18.107 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr4_-_2263808 18.098 MXD4
MAX dimerization protein 4
chr18_-_74728963 17.926 MBP
myelin basic protein
chr12_-_9268475 17.865 A2M
alpha-2-macroglobulin
chr11_+_67007484 17.843 LOC100131150
uncharacterized LOC100131150
chr5_+_170736287 17.344 NM_021025
TLX3
T-cell leukemia homeobox 3
chr3_-_114478117 17.006 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr2_+_143886898 16.964 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr2_+_74120132 16.904 ACTG2
actin, gamma 2, smooth muscle, enteric
chr5_-_11903964 16.879 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr12_-_11548485 16.855 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr11_-_117747331 16.835 FXYD6
FXYD domain containing ion transport regulator 6
chr2_+_74120092 16.674 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr4_-_176733413 16.482 GPM6A
glycoprotein M6A
chr3_+_111717585 16.214 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr4_+_78078394 16.025 CCNG2
cyclin G2
chr3_-_14988976 16.020 LOC100505641
uncharacterized LOC100505641
chr7_-_27205148 15.551 NM_152739
HOXA9
homeobox A9
chr11_+_71791376 15.538 NM_001145307
NM_001145308
NM_001205138
NM_145309
LRTOMT



leucine rich transmembrane and 0-methyltransferase domain containing



chr5_-_146435589 15.306 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr2_+_189839132 15.301 COL3A1
collagen, type III, alpha 1
chr2_+_143886969 15.243 ARHGAP15
Rho GTPase activating protein 15
chr4_-_186577858 15.207 SORBS2
sorbin and SH3 domain containing 2
chr3_-_14988939 15.151 LOC100505641
uncharacterized LOC100505641
chr12_-_10282680 15.092 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr12_-_6233684 14.739 NM_000552
VWF
von Willebrand factor
chr2_-_157189040 14.699 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_-_226926875 14.609 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr2_-_86564632 14.497 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr15_+_66994669 14.480 NM_005585
SMAD6
SMAD family member 6
chr10_+_63661012 14.435 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr2_+_169923531 14.395 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_-_32497925 14.348 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr9_-_95298251 14.348 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr11_+_128564130 14.340 FLI1
Friend leukemia virus integration 1
chr4_-_5890142 14.281 CRMP1
collapsin response mediator protein 1
chr11_+_128563955 14.187 FLI1
Friend leukemia virus integration 1
chr6_-_32557431 14.098 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr5_+_172483285 14.086 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr1_-_201476218 14.063 CSRP1
cysteine and glycine-rich protein 1
chr2_+_203499819 14.018 NM_173511
FAM117B
family with sequence similarity 117, member B
chr2_+_90211704 13.790


chr7_-_37025696 13.775 ELMO1
engulfment and cell motility 1
chr1_+_244998592 13.764 NM_198076
FAM36A
family with sequence similarity 36, member A
chr4_-_71532341 13.760 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_-_208989081 13.752 NM_006891
CRYGD
crystallin, gamma D
chr15_+_93443418 13.675 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr11_+_112832089 13.666 NCAM1
neural cell adhesion molecule 1
chr14_-_50697940 13.625 SOS2
son of sevenless homolog 2 (Drosophila)
chr1_-_182360400 13.558 NM_001033056
GLUL
glutamate-ammonia ligase
chr3_+_122044010 13.444 NM_005213
CSTA
cystatin A (stefin A)
chr1_+_156589085 13.373 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr2_-_174767282 13.291


chr19_+_58790306 13.287 NM_021089
ZNF8
zinc finger protein 8
chr3_-_58563070 13.276 FAM107A
family with sequence similarity 107, member A
chr9_-_23826062 13.267 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr8_-_72273965 13.246 EYA1
eyes absent homolog 1 (Drosophila)
chr11_+_113931228 13.206 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr3_-_47933997 13.184 MAP4
microtubule-associated protein 4
chr3_-_187454247 13.083 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr2_+_162272892 13.053 TBR1
T-box, brain, 1
chr8_-_33424642 13.038 NM_024787
RNF122
ring finger protein 122
chr4_-_186732047 13.038 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr1_+_201476283 12.995


chr3_-_114343052 12.951 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_140739589 12.869 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr12_-_16759939 12.691 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_14989399 12.627 LOC100505641
uncharacterized LOC100505641
chr4_-_101439071 12.605 NM_001159694
NM_016242
EMCN

endomucin

chr2_-_128421965 12.413 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr5_-_169724614 12.397 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_-_201476248 12.291 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr4_+_175204827 12.277 NM_001040157
CEP44
centrosomal protein 44kDa
chr20_+_20348744 12.240 NM_002196
INSM1
insulinoma-associated 1
chr1_-_57045129 12.222 PPAP2B
phosphatidic acid phosphatase type 2B
chr16_-_3930713 12.117 CREBBP
CREB binding protein
chr20_+_17207680 12.099 PCSK2
proprotein convertase subtilisin/kexin type 2
chr7_-_27183225 12.057 NM_019102
HOXA5
homeobox A5
chr7_-_137028433 12.013 PTN
pleiotrophin
chr1_-_201476241 11.960 CSRP1
cysteine and glycine-rich protein 1
chr4_-_2263706 11.957 NM_006454
MXD4
MAX dimerization protein 4
chr1_+_198608244 11.920 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_-_40324747 11.907 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr8_+_22210311 11.890 PIWIL2
piwi-like 2 (Drosophila)
chr14_-_60097531 11.846 NM_206852
RTN1
reticulon 1
chr18_-_53255361 11.825 TCF4
transcription factor 4
chr1_-_201475966 11.737 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr7_+_111846736 11.674 ZNF277
zinc finger protein 277
chr17_-_37764165 11.664 NM_006160
NEUROD2
neurogenic differentiation 2
chr2_-_136873740 11.524 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr4_-_186732208 11.479 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr6_+_148664124 11.451 SASH1
SAM and SH3 domain containing 1
chr16_-_31085503 11.403 NM_024706
ZNF668
zinc finger protein 668
chr5_+_15500288 11.377 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr11_+_128563993 11.367 FLI1
Friend leukemia virus integration 1
chr18_+_7946885 11.291 PTPRM
protein tyrosine phosphatase, receptor type, M
chr9_-_77503009 11.231 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr11_+_73359734 11.224 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr16_+_31085722 11.212 NM_014699
ZNF646
zinc finger protein 646
chr7_-_27187367 11.209 NM_024014
HOXA6
homeobox A6
chr1_-_57888785 11.196 DAB1
disabled homolog 1 (Drosophila)
chr17_+_3100809 11.179 NM_012352
OR1A2
olfactory receptor, family 1, subfamily A, member 2
chr15_+_25200069 11.173 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr1_+_155853546 11.138 SYT11
synaptotagmin XI
chr2_-_216259197 11.112 FN1
fibronectin 1
chr19_+_56166418 11.101 U2AF2
U2 small nuclear RNA auxiliary factor 2
chr2_+_148602050 11.051 ACVR2A
activin A receptor, type IIA
chr12_-_11508509 11.044 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr2_-_218843541 11.044 TNS1
tensin 1
chr8_-_87755880 11.044 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr7_-_137028275 11.003 PTN
pleiotrophin
chr6_+_7108864 10.993 RREB1
ras responsive element binding protein 1
chr16_+_31085751 10.906 ZNF646
zinc finger protein 646
chr8_+_26435920 10.891 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr9_-_36400817 10.888 NM_194328
NM_194332
RNF38

ring finger protein 38

chr5_+_140797270 10.887 PCDHGB7
protocadherin gamma subfamily B, 7
chr4_+_3294711 10.866 RGS12
regulator of G-protein signaling 12
chr1_-_57045214 10.854 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_-_115934363 10.797 NM_018017
C10orf118
chromosome 10 open reading frame 118
chr4_-_176733901 10.728 GPM6A
glycoprotein M6A
chr12_+_52445185 10.689 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr7_+_30960914 10.681 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr11_+_112832201 10.681 NCAM1
neural cell adhesion molecule 1
chr12_-_10251520 10.674 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr22_-_50523737 10.672 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr13_-_67804432 10.656 NM_020403
NM_203487
PCDH9

protocadherin 9

chr22_-_19512859 10.654 NM_001130861
NM_003277
CLDN5

claudin 5

chr6_-_134496833 10.645 SGK1
serum/glucocorticoid regulated kinase 1
chr17_+_36861857 10.556 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr7_+_106505696 10.538 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_-_195306274 10.533 APOD
apolipoprotein D
chr1_+_244998967 10.524 FAM36A
family with sequence similarity 36, member A
chr3_-_66024508 10.517 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr5_+_140864626 10.496 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr1_+_39875175 10.482 NM_015038
KIAA0754
KIAA0754
chr7_-_137028370 10.414 PTN
pleiotrophin
chr4_+_159690208 10.412 FNIP2
folliculin interacting protein 2
chr9_-_123476578 10.386 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr20_+_17207596 10.386 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr6_-_152957985 10.376 NM_033071
SYNE1
spectrin repeat containing, nuclear envelope 1
chr4_+_175205044 10.365 NM_001145314
CEP44
centrosomal protein 44kDa
chr22_-_50523780 10.347 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr11_+_128563973 10.296 FLI1
Friend leukemia virus integration 1
chr6_+_41040713 10.266 NFYA
nuclear transcription factor Y, alpha
chr16_+_31271327 10.230 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr18_-_13915534 10.228 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr1_-_57045235 10.211 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_163113129 10.189 RGS5
regulator of G-protein signaling 5
chr17_+_30814708 10.064


chr2_+_12857885 10.063 TRIB2
tribbles homolog 2 (Drosophila)
chr1_-_182360181 10.059 GLUL
glutamate-ammonia ligase
chr6_-_134498973 10.042 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr14_-_50698090 10.018 NM_006939
SOS2
son of sevenless homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.57 2.19e-33 GO:0032502 developmental process
1.57 1.04e-29 GO:0007275 multicellular organismal development
1.42 4.05e-29 GO:0032501 multicellular organismal process
1.59 8.64e-28 GO:0048856 anatomical structure development
1.59 1.24e-24 GO:0048731 system development
1.26 1.32e-22 GO:0065007 biological regulation
1.84 2.08e-22 GO:0007399 nervous system development
1.27 5.25e-20 GO:0050789 regulation of biological process
1.45 7.84e-20 GO:0023052 signaling
1.28 1.97e-19 GO:0050794 regulation of cellular process
1.62 9.58e-18 GO:0030154 cell differentiation
1.75 1.08e-17 GO:0009653 anatomical structure morphogenesis
1.60 2.02e-17 GO:0048869 cellular developmental process
1.15 2.04e-17 GO:0009987 cellular process
1.42 4.83e-15 GO:0007165 signal transduction
1.26 3.21e-13 GO:0050896 response to stimulus
1.34 7.81e-13 GO:0051716 cellular response to stimulus
2.54 3.54e-12 GO:0016337 cell-cell adhesion
1.92 5.10e-12 GO:0007155 cell adhesion
1.92 5.10e-12 GO:0022610 biological adhesion
2.03 1.58e-11 GO:0009887 organ morphogenesis
1.52 4.06e-11 GO:0048513 organ development
3.24 8.41e-11 GO:0007156 homophilic cell adhesion
1.89 3.68e-10 GO:0030182 neuron differentiation
1.62 4.71e-10 GO:0051239 regulation of multicellular organismal process
1.76 5.24e-10 GO:0022008 neurogenesis
1.51 5.35e-10 GO:0007166 cell surface receptor linked signaling pathway
1.77 1.04e-09 GO:0048699 generation of neurons
1.83 1.44e-09 GO:2000026 regulation of multicellular organismal development
1.45 1.69e-09 GO:0048523 negative regulation of cellular process
1.39 1.93e-09 GO:0048518 positive regulation of biological process
1.76 2.68e-09 GO:0040011 locomotion
1.41 2.88e-09 GO:0048522 positive regulation of cellular process
2.01 5.26e-09 GO:0000904 cell morphogenesis involved in differentiation
1.41 9.77e-09 GO:0048519 negative regulation of biological process
1.73 1.17e-08 GO:0006351 transcription, DNA-dependent
1.70 1.74e-08 GO:0050793 regulation of developmental process
2.07 2.80e-08 GO:0007409 axonogenesis
2.04 3.70e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
2.21 5.34e-08 GO:0051093 negative regulation of developmental process
1.79 1.40e-07 GO:0045595 regulation of cell differentiation
1.44 1.58e-07 GO:0048583 regulation of response to stimulus
1.98 2.43e-07 GO:0048812 neuron projection morphogenesis
1.66 2.50e-07 GO:0048468 cell development
1.81 3.28e-07 GO:0032989 cellular component morphogenesis
1.47 4.48e-07 GO:0023051 regulation of signaling
1.82 5.01e-07 GO:0000902 cell morphogenesis
1.81 2.15e-06 GO:0048666 neuron development
1.86 2.25e-06 GO:0007417 central nervous system development
1.59 3.93e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.20 4.96e-06 GO:0045596 negative regulation of cell differentiation
1.59 5.07e-06 GO:0032774 RNA biosynthetic process
1.75 6.41e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.47 6.59e-06 GO:0009966 regulation of signal transduction
1.34 6.99e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.36 7.07e-06 GO:0042221 response to chemical stimulus
1.84 1.04e-05 GO:0031175 neuron projection development
1.72 1.06e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.82 1.25e-05 GO:0048858 cell projection morphogenesis
1.70 1.27e-05 GO:0010628 positive regulation of gene expression
2.02 1.80e-05 GO:0007411 axon guidance
1.33 1.85e-05 GO:0010556 regulation of macromolecule biosynthetic process
2.04 1.86e-05 GO:0001501 skeletal system development
1.35 1.94e-05 GO:0006355 regulation of transcription, DNA-dependent
1.81 1.98e-05 GO:0032990 cell part morphogenesis
1.64 2.36e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.56 2.69e-05 GO:0045165 cell fate commitment
1.65 2.78e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.77 3.55e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.62 4.46e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.70 6.13e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.81 6.31e-05 GO:0072358 cardiovascular system development
1.81 6.31e-05 GO:0072359 circulatory system development
1.30 6.84e-05 GO:0031326 regulation of cellular biosynthetic process
2.62 6.88e-05 GO:0048705 skeletal system morphogenesis
1.53 7.54e-05 GO:0007154 cell communication
1.30 7.94e-05 GO:0009889 regulation of biosynthetic process
2.05 8.82e-05 GO:0007423 sensory organ development
1.33 8.82e-05 GO:0051252 regulation of RNA metabolic process
1.61 9.68e-05 GO:0007267 cell-cell signaling
1.25 9.95e-05 GO:0031323 regulation of cellular metabolic process
1.73 1.02e-04 GO:0051253 negative regulation of RNA metabolic process
1.87 1.03e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.26 1.23e-04 GO:0060255 regulation of macromolecule metabolic process
1.69 1.36e-04 GO:0010629 negative regulation of gene expression
1.57 1.54e-04 GO:0009891 positive regulation of biosynthetic process
1.57 1.70e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.64 1.84e-04 GO:0051254 positive regulation of RNA metabolic process
1.66 1.93e-04 GO:0030030 cell projection organization
1.65 1.97e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.29 2.05e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.71 2.09e-04 GO:0006928 cellular component movement
1.30 2.17e-04 GO:0010468 regulation of gene expression
1.24 2.33e-04 GO:0080090 regulation of primary metabolic process
1.78 2.77e-04 GO:0048870 cell motility
1.78 2.77e-04 GO:0051674 localization of cell
1.63 2.90e-04 GO:0031327 negative regulation of cellular biosynthetic process
2.31 3.18e-04 GO:0030900 forebrain development
1.82 3.21e-04 GO:0016477 cell migration
1.22 4.90e-04 GO:0019222 regulation of metabolic process
1.61 4.91e-04 GO:0009890 negative regulation of biosynthetic process
1.75 5.49e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.65 5.50e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64 5.56e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.86 6.32e-04 GO:0007420 brain development
2.07 6.62e-04 GO:0003002 regionalization
1.71 7.07e-04 GO:0006935 chemotaxis
1.71 7.07e-04 GO:0042330 taxis
2.91 8.55e-04 GO:0048706 embryonic skeletal system development
1.54 8.60e-04 GO:0051128 regulation of cellular component organization
1.75 8.93e-04 GO:0051094 positive regulation of developmental process
2.88 1.13e-03 GO:0055123 digestive system development
1.94 1.16e-03 GO:0051270 regulation of cellular component movement
1.59 1.24e-03 GO:0009790 embryo development
1.48 1.35e-03 GO:0009605 response to external stimulus
2.99 1.40e-03 GO:0048565 digestive tract development
1.26 1.69e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.98 1.78e-03 GO:0008361 regulation of cell size
1.98 2.04e-03 GO:0030334 regulation of cell migration
3.09 2.24e-03 GO:0032526 response to retinoic acid
2.91 2.50e-03 GO:0033189 response to vitamin A
1.67 2.63e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.58 2.87e-03 GO:0009719 response to endogenous stimulus
1.95 3.07e-03 GO:2000145 regulation of cell motility
2.26 3.12e-03 GO:0048562 embryonic organ morphogenesis
1.40 3.96e-03 GO:0010033 response to organic substance
1.86 3.98e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.82 4.84e-03 GO:0032535 regulation of cellular component size
1.88 5.20e-03 GO:0001944 vasculature development
1.88 5.20e-03 GO:0040012 regulation of locomotion
1.84 5.41e-03 GO:0060284 regulation of cell development
1.58 6.21e-03 GO:0009725 response to hormone stimulus
1.77 6.22e-03 GO:0048598 embryonic morphogenesis
1.47 6.24e-03 GO:0031324 negative regulation of cellular metabolic process
1.37 6.82e-03 GO:0035556 intracellular signal transduction
1.79 7.19e-03 GO:0007389 pattern specification process
2.76 7.39e-03 GO:0030336 negative regulation of cell migration
2.76 7.39e-03 GO:2000146 negative regulation of cell motility
1.39 7.80e-03 GO:0002376 immune system process
1.71 8.42e-03 GO:0040008 regulation of growth
2.67 9.21e-03 GO:0051271 negative regulation of cellular component movement
1.38 9.67e-03 GO:0009893 positive regulation of metabolic process
1.21 9.70e-03 GO:0016043 cellular component organization
1.42 1.15e-02 GO:0010646 regulation of cell communication
2.05 1.24e-02 GO:0048732 gland development
1.69 1.25e-02 GO:0008285 negative regulation of cell proliferation
1.40 1.32e-02 GO:0010604 positive regulation of macromolecule metabolic process
2.56 1.39e-02 GO:0021537 telencephalon development
2.56 1.39e-02 GO:0040013 negative regulation of locomotion
3.19 1.39e-02 GO:0001764 neuron migration
1.84 1.44e-02 GO:0030029 actin filament-based process
1.43 1.73e-02 GO:0009892 negative regulation of metabolic process
1.45 1.82e-02 GO:0010605 negative regulation of macromolecule metabolic process
2.00 1.89e-02 GO:0045664 regulation of neuron differentiation
2.13 1.96e-02 GO:0009952 anterior/posterior pattern formation
2.06 1.97e-02 GO:0003012 muscle system process
1.38 1.98e-02 GO:0031325 positive regulation of cellular metabolic process
1.64 2.12e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.84 2.42e-02 GO:0048545 response to steroid hormone stimulus
1.27 2.52e-02 GO:0065008 regulation of biological quality
1.85 2.55e-02 GO:0001568 blood vessel development
1.65 2.69e-02 GO:0023057 negative regulation of signaling
2.95 2.79e-02 GO:0050680 negative regulation of epithelial cell proliferation
1.42 2.96e-02 GO:0042127 regulation of cell proliferation
1.70 3.36e-02 GO:0009792 embryo development ending in birth or egg hatching
1.64 3.50e-02 GO:0007268 synaptic transmission
1.59 3.64e-02 GO:0043065 positive regulation of apoptosis
3.22 4.09e-02 GO:0048663 neuron fate commitment
1.69 4.41e-02 GO:0043009 chordate embryonic development
1.41 4.63e-02 GO:0032879 regulation of localization
1.58 4.67e-02 GO:0043068 positive regulation of programmed cell death
1.42 4.73e-02 GO:0009611 response to wounding
1.44 4.79e-02 GO:0009888 tissue development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 1.84e-13 GO:0044459 plasma membrane part
1.26 3.11e-08 GO:0005886 plasma membrane
1.26 4.22e-08 GO:0071944 cell periphery
1.78 1.71e-07 GO:0030054 cell junction
2.03 2.07e-06 GO:0005578 proteinaceous extracellular matrix
1.91 4.23e-06 GO:0031012 extracellular matrix
1.52 5.96e-06 GO:0044421 extracellular region part
1.45 2.58e-05 GO:0005887 integral to plasma membrane
1.43 4.05e-05 GO:0031226 intrinsic to plasma membrane
2.59 7.47e-05 GO:0044420 extracellular matrix part
1.78 1.05e-04 GO:0045202 synapse
1.91 1.58e-04 GO:0044456 synapse part
1.29 1.12e-03 GO:0005576 extracellular region
1.46 1.24e-03 GO:0042995 cell projection
3.69 1.42e-03 GO:0005581 collagen
1.99 2.46e-03 GO:0005911 cell-cell junction
1.65 9.03e-03 GO:0009986 cell surface
1.43 1.39e-02 GO:0005615 extracellular space
2.03 1.67e-02 GO:0045211 postsynaptic membrane
1.70 2.23e-02 GO:0015629 actin cytoskeleton
1.91 2.58e-02 GO:0030424 axon
2.09 3.69e-02 GO:0043292 contractile fiber
1.88 3.78e-02 GO:0031252 cell leading edge

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.88 1.63e-16 GO:0001071 nucleic acid binding transcription factor activity
1.88 1.63e-16 GO:0003700 sequence-specific DNA binding transcription factor activity
1.12 7.89e-15 GO:0005488 binding
1.90 2.25e-11 GO:0043565 sequence-specific DNA binding
1.69 1.59e-10 GO:0030528 transcription regulator activity
1.79 1.92e-08 GO:0005509 calcium ion binding
1.17 9.54e-08 GO:0005515 protein binding
1.32 1.27e-05 GO:0003677 DNA binding
1.23 1.56e-05 GO:0043167 ion binding
1.23 2.08e-05 GO:0043169 cation binding
1.23 2.09e-05 GO:0046872 metal ion binding
1.93 6.23e-05 GO:0016563 transcription activator activity
1.90 1.12e-03 GO:0032403 protein complex binding
2.02 1.77e-03 GO:0000975 regulatory region DNA binding
2.02 1.77e-03 GO:0001067 regulatory region nucleic acid binding
2.02 1.77e-03 GO:0044212 transcription regulatory region DNA binding
2.90 2.95e-03 GO:0005178 integrin binding
2.01 3.26e-03 GO:0010843 promoter binding
2.43 4.22e-03 GO:0004222 metalloendopeptidase activity
1.56 6.50e-03 GO:0008092 cytoskeletal protein binding
4.98 1.24e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
4.69 2.37e-02 GO:0005212 structural constituent of eye lens
1.63 2.95e-02 GO:0000988 protein binding transcription factor activity
1.63 2.95e-02 GO:0000989 transcription factor binding transcription factor activity
1.66 4.26e-02 GO:0003779 actin binding
2.79 4.45e-02 GO:0004879 ligand-dependent nuclear receptor activity
1.61 4.96e-02 GO:0003712 transcription cofactor activity