Motif ID: HIF1A.p2

Z-value: 3.506


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_621643390.621.0e-24Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_156931631 117.088 NM_014671
UBE3C
ubiquitin protein ligase E3C
chr1_-_8939150 108.355 NM_001428
ENO1
enolase 1, (alpha)
chr7_+_156931663 103.755 UBE3C
ubiquitin protein ligase E3C
chr3_-_81810618 72.415 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_-_8938745 69.538 ENO1
enolase 1, (alpha)
chr12_+_131356617 68.439 RAN
RAN, member RAS oncogene family
chr11_+_18416111 68.012 LDHA
lactate dehydrogenase A
chr11_+_18416106 66.001 LDHA
lactate dehydrogenase A
chr3_-_81810914 65.846 NM_000158
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_+_193091220 65.468 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr1_-_8938727 63.730 ENO1
enolase 1, (alpha)
chr6_-_7910278 62.360 NM_001145549
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr11_-_64014140 61.224 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_-_198364997 59.104 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_8938691 59.064 ENO1
enolase 1, (alpha)
chr2_+_113403433 56.140 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr11_+_18415917 55.913 NM_001135239
NM_001165415
NM_001165416
NM_005566
LDHA



lactate dehydrogenase A



chr3_+_52719935 54.380 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr8_+_48920969 52.138 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr17_+_49230938 50.997 NME1
NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in
NME1-NME2 readthrough
chr3_-_81810816 49.472 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_+_193091057 48.505 NM_024529
CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr1_-_43637788 48.008 EBNA1BP2
EBNA1 binding protein 2
chr2_-_10588451 47.855 NM_002539
ODC1
ornithine decarboxylase 1
chr3_-_145879222 47.654 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr17_+_49230929 46.984 NME1
non-metastatic cells 1, protein (NM23A) expressed in
chr2_-_198364522 46.352 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr2_+_198365012 46.242 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr4_+_57302448 45.901 PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr2_-_198364560 44.816 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_78149093 44.498 ZZZ3
zinc finger, ZZ-type containing 3
chr2_-_198364623 44.112 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chrX_+_77359712 43.522 PGK1
phosphoglycerate kinase 1
chr2_+_198365113 43.050 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr17_+_49230954 42.830 NME1
NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in
NME1-NME2 readthrough
chr8_+_55047780 42.721 NM_014175
MRPL15
mitochondrial ribosomal protein L15
chr19_+_39421347 42.488 NM_033362
MRPS12
mitochondrial ribosomal protein S12
chrX_+_77359768 42.391 PGK1
phosphoglycerate kinase 1
chrX_+_77359665 42.264 NM_000291
PGK1
phosphoglycerate kinase 1
chr8_+_97274106 42.122 PTDSS1
phosphatidylserine synthase 1
chr1_-_78148326 41.851 NM_015534
ZZZ3
zinc finger, ZZ-type containing 3
chr1_+_193091283 41.755 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr7_+_117824085 40.936 NM_016200
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr17_+_49230896 40.838 NM_000269
NM_198175
NM_001018136
NME1

NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in

NME1-NME2 readthrough
chr9_-_113018802 40.315 TXN
thioredoxin
chr22_+_20105095 39.970 RANBP1
RAN binding protein 1
chr10_+_3110818 38.400 NM_001242339
PFKP
phosphofructokinase, platelet
chr2_+_198364720 37.736 NM_001202485
NM_002157
HSPE1-MOB4
HSPE1
HSPE1-MOB4 readthrough
heat shock 10kDa protein 1 (chaperonin 10)
chr1_-_43637958 36.941 EBNA1BP2
EBNA1 binding protein 2
chr16_-_87903028 35.988 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr3_-_145878936 35.921 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr5_+_170814707 35.907 NM_001037738
NM_002520
NM_199185
NPM1


nucleophosmin (nucleolar phosphoprotein B23, numatrin)


chrX_+_77359754 35.579 PGK1
phosphoglycerate kinase 1
chrX_+_69509878 35.366 NM_012310
KIF4A
kinesin family member 4A
chr13_+_41363546 35.035 NM_014252
SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr1_-_43833689 35.032 NM_022821
ELOVL1
ELOVL fatty acid elongase 1
chr22_-_30987866 34.845 NM_001243225
NM_014303
PES1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr19_+_50180408 34.492 NM_001207042
NM_001536
NM_198318
PRMT1


protein arginine methyltransferase 1


chr4_+_57302268 34.357 NM_001079524
NM_001079525
PAICS

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

chr2_+_187350870 33.769 NM_018471
ZC3H15
zinc finger CCCH-type containing 15
chr6_+_34204690 33.549 HMGA1
high mobility group AT-hook 1
chr9_+_138392473 33.465 NM_016034
MRPS2
mitochondrial ribosomal protein S2
chr12_+_131356557 33.324 NM_006325
RAN
RAN, member RAS oncogene family
chr1_+_193091165 33.294 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr11_-_64014407 33.032 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr5_+_170814952 32.813 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr1_-_43637969 32.688 NM_006824
NM_001159936
EBNA1BP2

EBNA1 binding protein 2

chr11_-_47664014 32.000 NM_014342
MTCH2
mitochondrial carrier 2
chr12_-_50677238 31.949 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr6_+_34204928 31.881 HMGA1
high mobility group AT-hook 1
chr12_+_70636773 31.752 NM_014515
NM_001199302
CNOT2

CCR4-NOT transcription complex, subunit 2

chr8_+_98656428 31.502 MTDH
metadherin
chr1_-_43833688 31.251 ELOVL1
ELOVL fatty acid elongase 1
chr13_+_41363642 31.211 SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr11_-_64014264 30.680 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_+_187351032 30.582 ZC3H15
zinc finger CCCH-type containing 15
chr1_-_26232890 30.346 NM_001145454
NM_005563
STMN1

stathmin 1

chr1_+_19578039 30.072 NM_016183
MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr1_+_43148359 29.134 YBX1
Y box binding protein 1
chr12_+_131356640 29.109 RAN
RAN, member RAS oncogene family
chr11_-_64014381 29.001 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr5_+_154393259 28.633 NM_001099293
KIF4B
kinesin family member 4B
chr17_+_35849997 28.562 DUSP14
dual specificity phosphatase 14
chr1_-_43833605 28.500 ELOVL1
ELOVL fatty acid elongase 1
chr1_-_43833668 28.494 ELOVL1
ELOVL fatty acid elongase 1
chr7_-_105162551 28.344 NM_019042
PUS7
pseudouridylate synthase 7 homolog (S. cerevisiae)
chr16_-_12009568 28.256


chr3_-_145878775 28.232 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr1_+_19578288 28.185 MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr9_+_100745456 28.171 NM_006401
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr19_-_4670375 27.806 NM_019107
C19orf10
chromosome 19 open reading frame 10
chr17_-_79828691 27.632 NM_001185077
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr2_-_10588273 27.439 ODC1
ornithine decarboxylase 1
chr19_+_14544216 27.388 PKN1
protein kinase N1
chr1_-_1822501 26.966 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr19_-_5720155 26.851 LONP1
lon peptidase 1, mitochondrial
chr2_+_187350992 26.656 ZC3H15
zinc finger CCCH-type containing 15
chr19_-_5720136 26.630 LONP1
lon peptidase 1, mitochondrial
chr20_-_5107185 26.628 NM_002592
PCNA
proliferating cell nuclear antigen
chr9_-_34637752 26.081 NM_005866
NM_147157
SIGMAR1

sigma non-opioid intracellular receptor 1

chr22_+_40742502 26.025 NM_000026
NM_001123378
ADSL

adenylosuccinate lyase

chr9_+_131451847 26.024 SET
SET nuclear oncogene
chr8_+_98656494 25.598 MTDH
metadherin
chr1_+_41445402 25.459 CTPS
CTP synthase
chr17_+_49243770 25.401 NM_001018139
NME2
non-metastatic cells 2, protein (NM23B) expressed in
chr1_+_214776494 24.896 NM_016343
CENPF
centromere protein F, 350/400kDa (mitosin)
chr1_+_111992105 24.824 ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr2_-_175113240 24.539 OLA1
Obg-like ATPase 1
chr5_+_134094460 24.410 NM_014829
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr1_+_65613211 24.344 NM_203464
NM_001005353
AK4

adenylate kinase 4

chrX_-_149106641 24.197 NM_001013845
CXorf40B
chromosome X open reading frame 40B
chr6_+_34205369 24.044 HMGA1
high mobility group AT-hook 1
chr22_+_20105068 23.662 RANBP1
RAN binding protein 1
chr17_+_36908999 23.628 NM_002795
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr22_-_30987819 23.473 PES1
pescadillo homolog 1, containing BRCT domain (zebrafish)
chr1_+_65613971 23.414 AK4
adenylate kinase 4
chr1_+_111991742 23.341 NM_001688
ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr5_-_131563481 23.314 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr1_+_111992047 23.308 ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr1_+_41445359 23.077 CTPS
CTP synthase
chr2_-_175113257 23.036 OLA1
Obg-like ATPase 1
chr1_-_19578030 22.813 KIAA0090
KIAA0090
chr1_+_111992089 22.780 ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr1_-_26233367 22.742 NM_203399
STMN1
stathmin 1
chr7_+_100303673 22.662 NM_005837
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr2_+_85198176 22.618 NM_020122
KCMF1
potassium channel modulatory factor 1
chr9_-_113018869 22.595 NM_001244938
NM_003329
TXN

thioredoxin

chr1_+_111992129 22.296 ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr8_-_117768059 22.074 NM_003756
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr8_-_117768032 22.013 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr1_-_45987548 21.935 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr7_+_139044997 21.622 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr20_+_31407696 21.581 NM_012325
MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr11_-_67169309 21.369 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr17_+_73257745 21.344 NM_015971
MRPS7
mitochondrial ribosomal protein S7
chr15_-_59225766 21.333 SLTM
SAFB-like, transcription modulator
chr6_+_34204663 21.322 HMGA1
high mobility group AT-hook 1
chr3_+_142315205 21.320 NM_001145319
PLS1
plastin 1
chr3_+_184081178 21.259 NM_006232
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr19_+_50180492 21.216 PRMT1
protein arginine methyltransferase 1
chr1_-_156308099 20.998 NM_001008800
NM_005998
CCT3

chaperonin containing TCP1, subunit 3 (gamma)

chr19_+_984316 20.996 NM_024100
WDR18
WD repeat domain 18
chr1_+_32687970 20.992 NM_003757
EIF3I
eukaryotic translation initiation factor 3, subunit I
chr11_+_60609428 20.988 NM_024098
CCDC86
coiled-coil domain containing 86
chr2_-_175113197 20.963 OLA1
Obg-like ATPase 1
chr11_+_85956260 20.788 EED
embryonic ectoderm development
chr1_+_32688010 20.617 EIF3I
eukaryotic translation initiation factor 3, subunit I
chr1_+_214776582 20.465 CENPF
centromere protein F, 350/400kDa (mitosin)
chr8_-_97273795 20.440 NM_015942
MTERFD1
MTERF domain containing 1
chr5_+_68462836 20.422 NM_031966
CCNB1
cyclin B1
chr19_+_8509802 20.402 NM_005968
NM_031203
HNRNPM

heterogeneous nuclear ribonucleoprotein M

chr16_-_66968265 20.380 NM_016062
FAM96B
family with sequence similarity 96, member B
chr2_+_181845605 20.244 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr17_+_35849950 20.188 NM_007026
DUSP14
dual specificity phosphatase 14
chr4_-_7069755 20.178 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr10_+_3109708 20.154 NM_002627
PFKP
phosphofructokinase, platelet
chr20_-_60718358 19.723 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr20_-_60718407 19.681 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr16_-_88851371 19.636 NM_001142864
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr20_+_57556322 19.494 TH1L
TH1-like (Drosophila)
chr19_-_5720158 19.442 NM_004793
LONP1
lon peptidase 1, mitochondrial
chr12_+_6643604 19.301 NM_002046
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr13_+_51484103 19.269 RNASEH2B
ribonuclease H2, subunit B
chr16_+_447175 19.102 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr12_+_6643967 18.998 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr6_-_97345760 18.919 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr2_-_86422591 18.916 IMMT
inner membrane protein, mitochondrial
chr15_+_79603427 18.856 NM_007364
TMED3
transmembrane emp24 protein transport domain containing 3
chr7_-_54826899 18.854 NM_001012456
NM_014302
SEC61G

Sec61 gamma subunit

chr8_+_98656329 18.787 NM_178812
MTDH
metadherin
chr2_+_216176818 18.758 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr1_-_159895258 18.665 TAGLN2
transgelin 2
chr9_+_112542496 18.543 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr7_+_66386228 18.491 C7orf42
chromosome 7 open reading frame 42
chr1_+_44440642 18.447 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr4_-_24586015 18.436 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr22_+_20105145 18.368 RANBP1
RAN binding protein 1
chr10_+_75910908 18.359 NM_001202450
NM_006721
ADK

adenosine kinase

chr5_+_110074708 18.305 SLC25A46
solute carrier family 25, member 46
chr7_+_139044696 18.299 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr17_+_40985425 18.258 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr18_+_9914202 18.215 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr1_+_111992082 18.213 ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr1_+_166808721 18.198 NM_017542
POGK
pogo transposable element with KRAB domain
chr1_-_156308064 18.163 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr6_-_109703553 18.120 CD164
CD164 molecule, sialomucin
chr20_+_37075276 18.116 SNHG11
small nucleolar RNA host gene 11 (non-protein coding)
chrX_-_107334749 18.060 NM_002814
NM_170750
PSMD10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr2_+_122513120 18.034 NM_004622
TSN
translin
chr14_+_96001297 17.983 NM_016417
GLRX5
glutaredoxin 5
chr2_-_64881040 17.982 NM_014755
SERTAD2
SERTA domain containing 2
chr4_-_24586145 17.799 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr22_+_20105076 17.762 RANBP1
RAN binding protein 1
chr20_+_57556295 17.720 NM_198976
TH1L
TH1-like (Drosophila)
chr14_-_105487365 17.717 CDCA4
cell division cycle associated 4
chr5_+_110074740 17.714 NM_138773
SLC25A46
solute carrier family 25, member 46
chr3_-_63849456 17.698 THOC7
THO complex 7 homolog (Drosophila)
chr6_+_30689414 17.685 TUBB
tubulin, beta class I
chr16_-_81129882 17.640 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr14_-_105487413 17.547 CDCA4
cell division cycle associated 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 7.93e-38 GO:0044237 cellular metabolic process
1.42 1.59e-28 GO:0008152 metabolic process
1.24 6.26e-27 GO:0009987 cellular process
1.44 9.01e-25 GO:0044238 primary metabolic process
1.58 4.94e-24 GO:0044260 cellular macromolecule metabolic process
1.63 9.85e-19 GO:0006807 nitrogen compound metabolic process
1.46 6.17e-18 GO:0043170 macromolecule metabolic process
1.63 6.48e-18 GO:0034641 cellular nitrogen compound metabolic process
1.68 3.27e-17 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 8.72e-13 GO:0071840 cellular component organization or biogenesis
1.62 1.22e-12 GO:0044267 cellular protein metabolic process
1.58 2.76e-12 GO:0071841 cellular component organization or biogenesis at cellular level
1.64 1.41e-11 GO:0090304 nucleic acid metabolic process
1.60 3.93e-11 GO:0044249 cellular biosynthetic process
1.58 8.31e-11 GO:0009058 biosynthetic process
1.47 1.31e-10 GO:0016043 cellular component organization
1.89 1.97e-10 GO:0044085 cellular component biogenesis
1.54 9.02e-10 GO:0071842 cellular component organization at cellular level
2.04 7.58e-09 GO:0046907 intracellular transport
1.56 3.63e-08 GO:0048523 negative regulation of cellular process
1.76 4.08e-08 GO:0051641 cellular localization
1.68 2.53e-07 GO:0009056 catabolic process
1.63 2.92e-07 GO:0006996 organelle organization
1.78 3.39e-07 GO:0051649 establishment of localization in cell
1.43 4.56e-07 GO:0019538 protein metabolic process
2.22 5.81e-07 GO:0034621 cellular macromolecular complex subunit organization
2.97 6.72e-07 GO:0071843 cellular component biogenesis at cellular level
1.57 7.18e-07 GO:0010467 gene expression
1.74 1.23e-06 GO:0044248 cellular catabolic process
1.48 1.39e-06 GO:0048519 negative regulation of biological process
2.98 1.73e-06 GO:0022613 ribonucleoprotein complex biogenesis
1.78 2.02e-06 GO:0007049 cell cycle
3.54 2.20e-06 GO:0042254 ribosome biogenesis
1.57 2.51e-06 GO:0016070 RNA metabolic process
1.66 3.89e-06 GO:0033036 macromolecule localization
2.05 3.89e-06 GO:0071822 protein complex subunit organization
1.99 1.16e-05 GO:0009057 macromolecule catabolic process
1.73 1.25e-05 GO:0022607 cellular component assembly
1.83 1.27e-05 GO:0043933 macromolecular complex subunit organization
1.96 1.34e-05 GO:0006396 RNA processing
1.88 1.53e-05 GO:0071844 cellular component assembly at cellular level
2.23 2.42e-05 GO:0006091 generation of precursor metabolites and energy
1.52 2.71e-05 GO:0044281 small molecule metabolic process
1.80 3.77e-05 GO:0033554 cellular response to stress
1.70 5.16e-05 GO:0043067 regulation of programmed cell death
1.53 5.38e-05 GO:0009059 macromolecule biosynthetic process
1.69 5.77e-05 GO:0008104 protein localization
1.70 6.14e-05 GO:0042981 regulation of apoptosis
1.52 1.17e-04 GO:0034645 cellular macromolecule biosynthetic process
1.67 1.22e-04 GO:0010941 regulation of cell death
2.34 1.22e-04 GO:0006412 translation
2.69 1.27e-04 GO:0006457 protein folding
2.20 1.78e-04 GO:0034622 cellular macromolecular complex assembly
1.92 2.06e-04 GO:0006259 DNA metabolic process
2.77 2.21e-04 GO:0006913 nucleocytoplasmic transport
2.85 2.69e-04 GO:0043623 cellular protein complex assembly
1.75 2.92e-04 GO:0051128 regulation of cellular component organization
2.74 2.96e-04 GO:0051169 nuclear transport
3.14 3.87e-04 GO:0050657 nucleic acid transport
3.14 3.87e-04 GO:0050658 RNA transport
3.14 3.87e-04 GO:0051236 establishment of RNA localization
1.80 5.77e-04 GO:0065003 macromolecular complex assembly
1.71 6.17e-04 GO:0045184 establishment of protein localization
1.42 7.29e-04 GO:0065008 regulation of biological quality
3.04 7.79e-04 GO:0006403 RNA localization
1.92 8.37e-04 GO:0044265 cellular macromolecule catabolic process
2.13 9.07e-04 GO:0044419 interspecies interaction between organisms
1.72 1.15e-03 GO:0022402 cell cycle process
1.64 1.24e-03 GO:0009892 negative regulation of metabolic process
1.94 1.29e-03 GO:0070271 protein complex biogenesis
2.29 1.45e-03 GO:0034660 ncRNA metabolic process
3.40 1.50e-03 GO:0006364 rRNA processing
1.91 1.58e-03 GO:0006974 response to DNA damage stimulus
1.68 1.84e-03 GO:0015031 protein transport
2.83 2.07e-03 GO:0006006 glucose metabolic process
1.92 2.24e-03 GO:0006461 protein complex assembly
1.32 2.30e-03 GO:0051234 establishment of localization
1.65 2.38e-03 GO:0010605 negative regulation of macromolecule metabolic process
2.81 2.41e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.13 2.62e-03 GO:0009259 ribonucleotide metabolic process
2.18 3.05e-03 GO:0051329 interphase of mitotic cell cycle
1.32 3.19e-03 GO:0006810 transport
2.51 3.52e-03 GO:0034470 ncRNA processing
1.29 3.55e-03 GO:0051179 localization
3.04 3.79e-03 GO:0051028 mRNA transport
3.22 3.96e-03 GO:0016072 rRNA metabolic process
1.82 4.09e-03 GO:0000278 mitotic cell cycle
2.23 4.20e-03 GO:0015980 energy derivation by oxidation of organic compounds
1.17 4.38e-03 GO:0050794 regulation of cellular process
4.12 4.84e-03 GO:0044264 cellular polysaccharide metabolic process
2.15 4.91e-03 GO:0051325 interphase
1.84 5.36e-03 GO:0016071 mRNA metabolic process
1.87 5.43e-03 GO:0044283 small molecule biosynthetic process
3.24 6.30e-03 GO:0034637 cellular carbohydrate biosynthetic process
1.58 6.37e-03 GO:0032268 regulation of cellular protein metabolic process
1.16 6.44e-03 GO:0050789 regulation of biological process
1.64 6.52e-03 GO:0008219 cell death
1.72 7.43e-03 GO:0022403 cell cycle phase
1.35 7.49e-03 GO:0048522 positive regulation of cellular process
1.95 7.79e-03 GO:0016032 viral reproduction
1.63 8.05e-03 GO:0016265 death
2.59 8.14e-03 GO:0022415 viral reproductive process
1.62 8.72e-03 GO:0031324 negative regulation of cellular metabolic process
1.69 9.54e-03 GO:0012501 programmed cell death
2.11 9.94e-03 GO:0008380 RNA splicing
1.80 1.02e-02 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.55 1.13e-02 GO:0051246 regulation of protein metabolic process
1.15 1.23e-02 GO:0065007 biological regulation
1.60 1.25e-02 GO:0055114 oxidation-reduction process
2.70 1.28e-02 GO:0007005 mitochondrion organization
2.07 1.33e-02 GO:0009150 purine ribonucleotide metabolic process
1.67 1.88e-02 GO:0006915 apoptosis
1.87 1.99e-02 GO:0060548 negative regulation of cell death
1.72 2.45e-02 GO:0005975 carbohydrate metabolic process
1.71 2.75e-02 GO:0051726 regulation of cell cycle
1.87 2.78e-02 GO:0043066 negative regulation of apoptosis
2.49 2.78e-02 GO:0031400 negative regulation of protein modification process
1.73 2.84e-02 GO:0042060 wound healing
4.03 3.03e-02 GO:0006458 'de novo' protein folding
1.85 3.11e-02 GO:0044262 cellular carbohydrate metabolic process
2.57 3.31e-02 GO:0000082 G1/S transition of mitotic cell cycle
1.97 3.37e-02 GO:0006281 DNA repair
2.91 3.58e-02 GO:0006414 translational elongation
1.85 3.69e-02 GO:0043069 negative regulation of programmed cell death
2.34 4.50e-02 GO:0019318 hexose metabolic process
1.68 4.63e-02 GO:0007167 enzyme linked receptor protein signaling pathway
4.48 4.74e-02 GO:0005977 glycogen metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 7.99e-50 GO:0044424 intracellular part
1.28 4.25e-47 GO:0005622 intracellular
1.43 1.37e-42 GO:0005737 cytoplasm
1.61 2.30e-40 GO:0044446 intracellular organelle part
1.59 1.12e-39 GO:0044422 organelle part
1.34 3.39e-38 GO:0043229 intracellular organelle
1.34 3.49e-38 GO:0043226 organelle
1.37 2.46e-35 GO:0043227 membrane-bounded organelle
1.37 3.36e-35 GO:0043231 intracellular membrane-bounded organelle
1.50 3.77e-31 GO:0044444 cytoplasmic part
1.88 5.09e-23 GO:0044428 nuclear part
1.83 6.92e-23 GO:0031974 membrane-enclosed lumen
1.82 3.73e-21 GO:0070013 intracellular organelle lumen
1.80 1.57e-20 GO:0043233 organelle lumen
1.80 1.99e-18 GO:0005829 cytosol
1.82 1.83e-16 GO:0031981 nuclear lumen
1.52 1.58e-15 GO:0032991 macromolecular complex
1.36 2.49e-14 GO:0005634 nucleus
2.29 1.71e-13 GO:0031967 organelle envelope
2.54 4.82e-13 GO:0005730 nucleolus
2.25 6.03e-13 GO:0031975 envelope
1.62 3.26e-11 GO:0031090 organelle membrane
1.52 7.78e-11 GO:0043228 non-membrane-bounded organelle
1.52 7.78e-11 GO:0043232 intracellular non-membrane-bounded organelle
1.76 9.88e-10 GO:0005739 mitochondrion
1.46 2.20e-09 GO:0043234 protein complex
1.07 1.25e-08 GO:0044464 cell part
1.07 1.30e-08 GO:0005623 cell
2.85 2.23e-08 GO:0005635 nuclear envelope
1.65 5.91e-07 GO:0005654 nucleoplasm
1.93 1.23e-06 GO:0044429 mitochondrial part
1.57 1.65e-06 GO:0012505 endomembrane system
1.84 3.64e-06 GO:0044432 endoplasmic reticulum part
2.04 3.78e-06 GO:0030529 ribonucleoprotein complex
1.64 2.86e-05 GO:0005783 endoplasmic reticulum
2.01 4.84e-05 GO:0005740 mitochondrial envelope
2.00 1.19e-04 GO:0031966 mitochondrial membrane
2.83 2.05e-04 GO:0031965 nuclear membrane
1.73 7.00e-04 GO:0005789 endoplasmic reticulum membrane
6.76 8.66e-04 GO:0031519 PcG protein complex
1.72 8.97e-04 GO:0042175 nuclear membrane-endoplasmic reticulum network
7.61 1.05e-03 GO:0032592 integral to mitochondrial membrane
2.47 1.13e-03 GO:0031252 cell leading edge
2.73 3.94e-03 GO:0044455 mitochondrial membrane part
1.98 4.20e-03 GO:0019866 organelle inner membrane
3.31 7.74e-03 GO:0005643 nuclear pore
2.44 8.92e-03 GO:0044445 cytosolic part
1.96 1.20e-02 GO:0005743 mitochondrial inner membrane
10.19 1.39e-02 GO:0030686 90S preribosome
1.69 1.61e-02 GO:0005694 chromosome
2.74 2.27e-02 GO:0005925 focal adhesion
2.92 2.37e-02 GO:0046930 pore complex
2.64 2.48e-02 GO:0030055 cell-substrate junction
3.50 2.51e-02 GO:0015935 small ribosomal subunit
3.92 3.01e-02 GO:0031970 organelle envelope lumen
4.20 3.44e-02 GO:0022627 cytosolic small ribosomal subunit
1.56 4.37e-02 GO:0044451 nucleoplasm part
2.61 4.56e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 6.65e-35 GO:0005515 protein binding
1.17 3.10e-17 GO:0005488 binding
1.89 1.60e-07 GO:0003723 RNA binding
1.47 4.44e-07 GO:0000166 nucleotide binding
1.26 1.71e-06 GO:0003824 catalytic activity
1.38 5.21e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.37 5.56e-03 GO:0017076 purine nucleotide binding
1.37 6.00e-03 GO:0032553 ribonucleotide binding
1.37 6.00e-03 GO:0032555 purine ribonucleotide binding
2.30 1.01e-02 GO:0003682 chromatin binding
4.13 2.56e-02 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity
1.57 2.99e-02 GO:0019899 enzyme binding