Motif ID: HMX1.p2

Z-value: 1.268


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMX1chr4_-_88734530.363.3e-08Click!


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_203499819 17.763 NM_173511
FAM117B
family with sequence similarity 117, member B
chr1_+_151254740 14.978 NM_020832
ZNF687
zinc finger protein 687
chr10_-_99531712 11.138 NM_003015
SFRP5
secreted frizzled-related protein 5
chr18_+_11981457 11.036 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chrX_-_107019001 10.473 NM_198057
TSC22D3
TSC22 domain family, member 3
chr11_+_61129831 9.607 TMEM138
transmembrane protein 138
chr13_-_41495804 9.158 LOC100616668
SUGT1P3
TPTE2 pseudogene
suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3
chr19_+_57752051 9.021 NM_001023563
NM_001145078
ZNF805

zinc finger protein 805

chr17_-_74236272 8.540 NM_052916
RNF157
ring finger protein 157
chr19_+_54058493 8.351 NM_001079907
ZNF331
zinc finger protein 331
chr19_+_54041332 8.202 NM_001079906
NM_001253798
NM_001253799
ZNF331


zinc finger protein 331


chrX_-_107018889 8.135 TSC22D3
TSC22 domain family, member 3
chr13_+_42031525 8.042 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr2_+_27346656 7.905 NM_032604
ABHD1
abhydrolase domain containing 1
chr16_-_86542463 7.796 LOC400550
uncharacterized LOC400550
chr17_+_28256873 7.683 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr1_-_154193044 7.670 C1orf43
chromosome 1 open reading frame 43
chr13_+_42031690 7.604 C13orf15
chromosome 13 open reading frame 15
chr13_+_42031679 7.576 C13orf15
chromosome 13 open reading frame 15
chr3_-_52312257 7.468 WDR82
WD repeat domain 82
chr7_-_37488554 7.384 NM_014800
ELMO1
engulfment and cell motility 1
chrX_-_13835187 7.370 GPM6B
glycoprotein M6B
chr19_+_54042041 7.316 NM_001253800
ZNF331
zinc finger protein 331
chr3_+_101546833 6.974 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr12_-_53448167 6.932 LOC283335
uncharacterized LOC283335
chr16_+_2653350 6.902 LOC652276
potassium channel tetramerisation domain containing 5 pseudogene
chr2_-_69870705 6.703 AAK1
AP2 associated kinase 1
chr20_-_590909 6.681 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr2_+_242641310 6.623 NM_032329
ING5
inhibitor of growth family, member 5
chr12_-_49392909 6.486 NM_015086
DDN
dendrin
chr9_-_136024522 6.343 NM_001042368
RALGDS
ral guanine nucleotide dissociation stimulator
chr2_-_69870837 6.270 AAK1
AP2 associated kinase 1
chr12_-_6798528 5.988 NM_133476
ZNF384
zinc finger protein 384
chr19_+_54057898 5.969 NM_001253801
ZNF331
zinc finger protein 331
chr7_-_37488408 5.968 ELMO1
engulfment and cell motility 1
chr19_+_13875345 5.855 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr1_+_145438437 5.850 NM_006472
TXNIP
thioredoxin interacting protein
chr10_-_120514669 5.825 NM_153810
C10orf46
chromosome 10 open reading frame 46
chr17_+_3627133 5.820 NM_031965
GSG2
germ cell associated 2 (haspin)
chr9_+_137967401 5.676 OLFM1
olfactomedin 1
chrX_-_13835012 5.616 GPM6B
glycoprotein M6B
chr5_-_130970851 5.521 RAPGEF6
Rap guanine nucleotide exchange factor (GEF) 6
chr3_-_18466759 5.510 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr5_-_130970907 5.257 NM_001164386
NM_001164387
NM_001164388
NM_001164389
NM_001164390
NM_016340
RAPGEF6





Rap guanine nucleotide exchange factor (GEF) 6





chr1_+_201476283 5.247


chr19_-_4535202 5.025 NM_001013706
PLIN5
perilipin 5
chr8_-_143999255 5.007 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr9_+_137967366 4.973 OLFM1
olfactomedin 1
chr4_+_176987148 4.962 WDR17
WD repeat domain 17
chr19_-_57183122 4.958 NM_001005850
ZNF835
zinc finger protein 835
chr19_+_13875352 4.954 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr19_+_50796820 4.939 MYH14
myosin, heavy chain 14, non-muscle
chr15_-_76030958 4.905 DNM1P35
DNM1 pseudogene 35
chr15_-_43941037 4.789 NM_054020
NM_172095
NM_172097
CATSPER2


cation channel, sperm associated 2


chr16_-_49315682 4.758 NM_004352
CBLN1
cerebellin 1 precursor
chr22_+_50781773 4.729 PPP6R2
protein phosphatase 6, regulatory subunit 2
chr10_+_126150340 4.724 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr16_+_69166538 4.707 CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr2_-_101925051 4.702 NM_173647
RNF149
ring finger protein 149
chr14_-_101034261 4.676 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr9_+_137967267 4.637 OLFM1
olfactomedin 1
chr12_+_112451229 4.603


chr5_-_68485278 4.599


chr4_+_176986984 4.585 NM_170710
NM_181265
WDR17

WD repeat domain 17

chrX_-_13835213 4.519 GPM6B
glycoprotein M6B
chr17_-_78450247 4.503 NM_002522
NPTX1
neuronal pentraxin I
chr2_+_61293038 4.498 KIAA1841
KIAA1841
chr8_+_24772454 4.461 NM_001105541
NEFM
neurofilament, medium polypeptide
chr19_-_14952688 4.439 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr14_+_101300806 4.436 MEG3
maternally expressed 3 (non-protein coding)
chr5_+_148206155 4.411 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr22_-_20104745 4.392 NM_022727
NM_182984
TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

chr5_+_56110899 4.378 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr19_-_37019169 4.354 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr21_-_40032563 4.353 NM_001243428
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr17_+_21279667 4.349 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr16_-_70713927 4.331 MTSS1L
metastasis suppressor 1-like
chr14_-_25078818 4.292 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr7_-_752742 4.272 NM_001164761
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr12_-_6798619 4.266 NM_001039920
NM_001135734
ZNF384

zinc finger protein 384

chrX_-_78622711 4.230 ITM2A
integral membrane protein 2A
chrX_-_13835313 4.227 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr5_-_58334936 4.172 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr21_+_41239346 4.155 NM_006198
PCP4
Purkinje cell protein 4
chr22_-_20104695 4.148 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr17_-_1619473 4.144 MIR22HG
MIR22 host gene (non-protein coding)
chr2_-_68384575 4.125 NM_138458
WDR92
WD repeat domain 92
chr17_-_34313685 4.082 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr6_+_33043702 4.079 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr19_+_5904842 4.027 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr4_-_109087876 4.006 NM_001166119
LEF1
lymphoid enhancer-binding factor 1
chr19_-_10341947 3.997 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr1_+_6052357 3.978 NM_001199861
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr1_+_156339002 3.953 NM_020407
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr22_-_18923654 3.938 PRODH
proline dehydrogenase (oxidase) 1
chr1_-_177133818 3.928 ASTN1
astrotactin 1
chr12_-_112819755 3.925 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr7_-_97881436 3.901 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr11_-_76155704 3.848


chr16_+_67226027 3.837 NM_001950
E2F4
E2F transcription factor 4, p107/p130-binding
chr12_-_122751044 3.823 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr17_+_41132587 3.800 RUNDC1
RUN domain containing 1
chr19_-_5680910 3.727 NM_205767
C19orf70
chromosome 19 open reading frame 70
chr19_+_47524142 3.722 NM_002517
NPAS1
neuronal PAS domain protein 1
chr19_+_58038744 3.720 ZNF549
zinc finger protein 549
chr18_-_21017816 3.707 NM_032933
TMEM241
transmembrane protein 241
chr16_+_67226098 3.699 E2F4
E2F transcription factor 4, p107/p130-binding
chr2_+_10091791 3.661 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr5_+_156693051 3.658 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr6_-_137113166 3.653


chr12_-_49365545 3.635 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr14_+_92790151 3.615 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr22_+_32149936 3.611 NM_001242897
DEPDC5
DEP domain containing 5
chr12_+_4382882 3.599 NM_001759
CCND2
cyclin D2
chr15_-_65117804 3.593 NM_025049
PIF1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr17_-_62097937 3.575 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr1_+_27719151 3.554 NM_005281
GPR3
G protein-coupled receptor 3
chr2_-_192015934 3.551 NM_003151
STAT4
signal transducer and activator of transcription 4
chr7_-_37488894 3.540 NM_001206480
ELMO1
engulfment and cell motility 1
chr16_+_50186809 3.534 NM_001040284
NM_001040285
PAPD5

PAP associated domain containing 5

chr1_-_1551041 3.531 MIB2
mindbomb homolog 2 (Drosophila)
chr17_-_28257017 3.529 NM_033389
SSH2
slingshot homolog 2 (Drosophila)
chr9_-_86571631 3.495 C9orf64
chromosome 9 open reading frame 64
chr11_+_1411089 3.488 NM_003957
BRSK2
BR serine/threonine kinase 2
chr17_+_79651052 3.473


chr2_+_230787195 3.454 NM_174899
FBXO36
F-box protein 36
chr2_-_192015751 3.449 STAT4
signal transducer and activator of transcription 4
chr17_-_8868931 3.417 NM_001142633
NM_001251851
NM_001251852
NM_001251853
NM_001251855
PIK3R5




phosphoinositide-3-kinase, regulatory subunit 5




chr11_+_64692052 3.415 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr7_-_140624280 3.408 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr17_-_39968823 3.401 LEPREL4
leprecan-like 4
chr17_+_72920369 3.392 NM_178160
OTOP2
otopetrin 2
chr2_-_192015706 3.388 STAT4
signal transducer and activator of transcription 4
chr1_-_59042827 3.373 TACSTD2
tumor-associated calcium signal transducer 2
chr2_+_61292999 3.341 NM_001129993
KIAA1841
KIAA1841
chr11_-_45307617 3.326 NM_001247987
NM_020826
SYT13

synaptotagmin XIII

chr9_-_86571533 3.325 C9orf64
chromosome 9 open reading frame 64
chr12_+_53440809 3.321 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_-_192015733 3.317 STAT4
signal transducer and activator of transcription 4
chrX_-_140271275 3.314 LDOC1
leucine zipper, down-regulated in cancer 1
chr7_-_4923246 3.288 NM_018059
RADIL
Ras association and DIL domains
chr15_+_34394273 3.271 NM_152595
PGBD4
piggyBac transposable element derived 4
chr5_-_115910406 3.269 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr11_+_76156059 3.269 NM_020193
C11orf30
chromosome 11 open reading frame 30
chr9_-_95432542 3.266 NM_022755
IPPK
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr16_+_69796237 3.261 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr19_+_57999078 3.257 NM_001098491
NM_001098492
NM_001098493
NM_001098494
NM_001098495
NM_001098496
NM_024691
ZNF419






zinc finger protein 419






chr1_-_9189087 3.255 NM_024980
GPR157
G protein-coupled receptor 157
chr1_+_15573767 3.226 NM_052929
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr15_+_64443909 3.194 NM_024798
SNX22
sorting nexin 22
chr1_+_203444955 3.191 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr3_-_42003460 3.176 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chr1_-_233431458 3.174 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr10_+_11060105 3.174 CELF2
CUGBP, Elav-like family member 2
chr11_-_236833 3.156 SIRT3
sirtuin 3
chr1_-_212588235 3.153 TMEM206
transmembrane protein 206
chr22_+_50781717 3.145 NM_001242898
NM_001242899
NM_001242900
NM_014678
PPP6R2



protein phosphatase 6, regulatory subunit 2



chr1_-_32229635 3.088 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr22_+_40766649 3.083 SGSM3
small G protein signaling modulator 3
chr4_-_8873453 3.079 NM_018942
HMX1
H6 family homeobox 1
chr1_+_36689996 3.076 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr12_-_6798419 3.069 ZNF384
zinc finger protein 384
chr2_-_167232464 3.065 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr22_-_18923963 3.040 NM_001195226
NM_016335
PRODH

proline dehydrogenase (oxidase) 1

chr4_-_8160435 3.036 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr1_+_36690038 3.009 THRAP3
thyroid hormone receptor associated protein 3
chr20_+_42187705 3.004 SGK2
serum/glucocorticoid regulated kinase 2
chr5_+_74807580 3.001 NM_016218
POLK
polymerase (DNA directed) kappa
chr17_-_27278324 2.995 PHF12
PHD finger protein 12
chr13_-_73356058 2.975 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr6_-_13486382 2.971 NM_001242628
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr16_+_67226070 2.969 E2F4
E2F transcription factor 4, p107/p130-binding
chr16_+_28996369 2.958 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr3_-_49466744 2.943 NM_032316
NICN1
nicolin 1
chr4_+_88720701 2.941 NM_004967
IBSP
integrin-binding sialoprotein
chr5_+_76326263 2.922 AGGF1
angiogenic factor with G patch and FHA domains 1
chr22_-_31741761 2.920 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr6_-_31763415 2.918 VARS
valyl-tRNA synthetase
chrX_-_140271293 2.913 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr5_+_87564840 2.906 LOC100505894
uncharacterized LOC100505894
chr8_+_26435339 2.898 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr19_+_496453 2.891 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr19_+_13875299 2.877 NM_001031727
NM_032285
MRI1

methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)

chr17_+_78194090 2.869 NM_001166347
NM_001166348
NM_001166349
NM_173626
SLC26A11



solute carrier family 26, member 11



chr8_+_26371461 2.867 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr17_+_28268622 2.860 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr6_+_41606193 2.859 NM_005586
MDFI
MyoD family inhibitor
chr8_-_143961232 2.859 NM_000497
NM_001026213
CYP11B1

cytochrome P450, family 11, subfamily B, polypeptide 1

chr6_-_13486986 2.857 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr1_-_7973286 2.830 UTS2
urotensin 2
chr6_+_99282579 2.815 NM_005604
POU3F2
POU class 3 homeobox 2
chr2_-_24583291 2.814 NM_006277
NM_019595
NM_147152
ITSN2


intersectin 2


chr2_+_113763448 2.807 NM_014440
IL36A
interleukin 36, alpha
chrX_+_133507299 2.800 NM_001015877
NM_032335
NM_032458
PHF6


PHD finger protein 6


chr10_-_135150368 2.795 CALY
calcyon neuron-specific vesicular protein
chr20_-_44600939 2.794 ZNF335
zinc finger protein 335
chr19_-_7939325 2.787 NM_001190467
FLJ22184
putative uncharacterized protein FLJ22184
chr20_-_35374530 2.764 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr6_-_32095974 2.734 ATF6B
activating transcription factor 6 beta
chr16_+_29985185 2.729 NM_001252043
NM_004783
NM_016151
TAOK2


TAO kinase 2



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.25 2.18e-14 GO:0065007 biological regulation
1.45 2.72e-14 GO:0023052 signaling
1.25 2.12e-12 GO:0050789 regulation of biological process
1.59 1.19e-11 GO:0030154 cell differentiation
1.43 1.20e-11 GO:0007275 multicellular organismal development
1.15 2.97e-11 GO:0009987 cellular process
1.25 3.21e-11 GO:0050794 regulation of cellular process
1.44 3.59e-11 GO:0048856 anatomical structure development
1.47 4.05e-11 GO:0048731 system development
1.57 5.53e-11 GO:0048869 cellular developmental process
1.39 7.77e-11 GO:0032502 developmental process
1.91 1.02e-10 GO:0050793 regulation of developmental process
1.41 1.91e-10 GO:0007165 signal transduction
2.00 2.81e-10 GO:2000026 regulation of multicellular organismal development
1.67 4.63e-10 GO:0007399 nervous system development
2.29 1.46e-09 GO:0051094 positive regulation of developmental process
1.71 1.48e-09 GO:0051239 regulation of multicellular organismal process
1.57 2.35e-09 GO:0048583 regulation of response to stimulus
1.29 3.24e-09 GO:0032501 multicellular organismal process
1.60 1.09e-08 GO:0023051 regulation of signaling
1.44 1.62e-08 GO:0048518 positive regulation of biological process
1.32 3.87e-08 GO:0051716 cellular response to stimulus
1.45 4.90e-08 GO:0048522 positive regulation of cellular process
1.61 1.17e-07 GO:0009966 regulation of signal transduction
1.52 3.34e-07 GO:0007166 cell surface receptor linked signaling pathway
1.63 5.63e-07 GO:0002376 immune system process
3.60 1.58e-06 GO:0051216 cartilage development
1.48 2.80e-06 GO:0048513 organ development
1.84 4.00e-06 GO:0045595 regulation of cell differentiation
1.53 8.15e-06 GO:0009653 anatomical structure morphogenesis
1.42 1.08e-05 GO:0048523 negative regulation of cellular process
1.40 1.17e-05 GO:0048519 negative regulation of biological process
1.70 1.88e-05 GO:0040011 locomotion
2.05 2.04e-05 GO:0016477 cell migration
2.17 3.45e-05 GO:0045597 positive regulation of cell differentiation
1.67 3.49e-05 GO:0048468 cell development
1.97 4.13e-05 GO:0048870 cell motility
1.97 4.13e-05 GO:0051674 localization of cell
1.30 5.93e-05 GO:0051179 localization
1.65 7.37e-05 GO:0022008 neurogenesis
1.40 7.91e-05 GO:0065008 regulation of biological quality
1.27 1.15e-04 GO:0019222 regulation of metabolic process
1.85 1.20e-04 GO:0006928 cellular component movement
1.19 1.31e-04 GO:0050896 response to stimulus
4.24 1.79e-04 GO:0060560 developmental growth involved in morphogenesis
1.64 2.53e-04 GO:0009888 tissue development
1.73 3.96e-04 GO:0010628 positive regulation of gene expression
1.28 4.91e-04 GO:0060255 regulation of macromolecule metabolic process
2.30 5.59e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.27 9.10e-04 GO:0080090 regulation of primary metabolic process
1.33 1.10e-03 GO:0010468 regulation of gene expression
1.81 1.37e-03 GO:0001775 cell activation
1.70 1.96e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.64 2.16e-03 GO:0006468 protein phosphorylation
1.79 2.49e-03 GO:0043065 positive regulation of apoptosis
2.00 2.77e-03 GO:0051093 negative regulation of developmental process
1.54 2.84e-03 GO:0009892 negative regulation of metabolic process
3.46 2.97e-03 GO:0031294 lymphocyte costimulation
3.46 2.97e-03 GO:0031295 T cell costimulation
2.02 2.99e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.63 3.03e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.77 3.07e-03 GO:0010942 positive regulation of cell death
1.78 3.19e-03 GO:0043068 positive regulation of programmed cell death
1.30 3.50e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 3.74e-03 GO:0031323 regulation of cellular metabolic process
1.91 3.80e-03 GO:0051056 regulation of small GTPase mediated signal transduction
5.95 3.98e-03 GO:0048675 axon extension
1.69 3.99e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.77 4.59e-03 GO:0007417 central nervous system development
1.77 4.76e-03 GO:0000904 cell morphogenesis involved in differentiation
1.44 5.83e-03 GO:0035556 intracellular signal transduction
1.50 5.83e-03 GO:0010646 regulation of cell communication
1.31 5.93e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.81 6.28e-03 GO:0048812 neuron projection morphogenesis
1.56 6.70e-03 GO:0048699 generation of neurons
1.57 6.74e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.81 7.05e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.54 7.32e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.55 7.38e-03 GO:0031324 negative regulation of cellular metabolic process
1.56 8.55e-03 GO:0009891 positive regulation of biosynthetic process
1.82 8.85e-03 GO:0007409 axonogenesis
1.68 9.39e-03 GO:0000902 cell morphogenesis
1.29 1.00e-02 GO:0031326 regulation of cellular biosynthetic process
1.47 1.01e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.50 1.04e-02 GO:0006793 phosphorus metabolic process
1.50 1.04e-02 GO:0006796 phosphate metabolic process
1.28 1.07e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.65 1.08e-02 GO:0030030 cell projection organization
1.30 1.12e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.57 1.18e-02 GO:0048584 positive regulation of response to stimulus
1.61 1.23e-02 GO:0002682 regulation of immune system process
1.76 1.24e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.74 1.24e-02 GO:0031175 neuron projection development
1.28 1.26e-02 GO:0009889 regulation of biosynthetic process
1.40 1.37e-02 GO:0065009 regulation of molecular function
1.44 1.49e-02 GO:0009893 positive regulation of metabolic process
1.88 1.50e-02 GO:0006917 induction of apoptosis
1.80 1.53e-02 GO:0007243 intracellular protein kinase cascade
1.80 1.53e-02 GO:0023014 signal transduction via phosphorylation event
1.87 1.65e-02 GO:0012502 induction of programmed cell death
1.31 1.66e-02 GO:0042221 response to chemical stimulus
1.92 1.72e-02 GO:0060284 regulation of cell development
1.54 1.99e-02 GO:0016310 phosphorylation
2.59 2.37e-02 GO:0035023 regulation of Rho protein signal transduction
2.05 2.39e-02 GO:0040007 growth
1.56 2.46e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.49 2.51e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.66 2.71e-02 GO:0048666 neuron development
1.30 2.73e-02 GO:0051252 regulation of RNA metabolic process
1.88 2.74e-02 GO:0007411 axon guidance
1.69 2.75e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.56 2.98e-02 GO:0006955 immune response
1.67 3.17e-02 GO:0051253 negative regulation of RNA metabolic process
1.31 3.18e-02 GO:0006355 regulation of transcription, DNA-dependent
1.82 3.31e-02 GO:0090066 regulation of anatomical structure size
1.98 3.43e-02 GO:0045596 negative regulation of cell differentiation
4.92 3.54e-02 GO:0048588 developmental cell growth
1.55 3.57e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
8.48 3.59e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
1.59 3.60e-02 GO:0051254 positive regulation of RNA metabolic process
1.61 3.77e-02 GO:0032989 cellular component morphogenesis
1.88 4.10e-02 GO:0001501 skeletal system development
3.46 4.16e-02 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
6.03 4.26e-02 GO:0030513 positive regulation of BMP signaling pathway
1.69 4.38e-02 GO:0048858 cell projection morphogenesis
2.36 4.58e-02 GO:0050870 positive regulation of T cell activation
2.00 4.59e-02 GO:0000165 MAPKKK cascade
1.57 4.64e-02 GO:0009790 embryo development
2.40 4.65e-02 GO:0001503 ossification
1.47 4.68e-02 GO:0009605 response to external stimulus
1.62 4.78e-02 GO:0010629 negative regulation of gene expression
1.59 4.92e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
2.83 4.92e-02 GO:0042063 gliogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 6.63e-12 GO:0044459 plasma membrane part
1.64 1.99e-08 GO:0005887 integral to plasma membrane
1.62 4.87e-08 GO:0031226 intrinsic to plasma membrane
1.26 8.21e-06 GO:0005886 plasma membrane
1.26 9.34e-06 GO:0071944 cell periphery
1.80 1.92e-03 GO:0043005 neuron projection
2.18 4.46e-03 GO:0030424 axon
1.41 2.33e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 5.34e-12 GO:0005488 binding
1.19 1.18e-07 GO:0005515 protein binding
1.51 1.27e-03 GO:0005102 receptor binding
2.35 2.21e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.73 4.09e-03 GO:0030695 GTPase regulator activity
2.73 7.77e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.69 1.01e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.93 1.08e-02 GO:0005261 cation channel activity
1.47 1.08e-02 GO:0030234 enzyme regulator activity
1.70 1.60e-02 GO:0004674 protein serine/threonine kinase activity
1.44 2.64e-02 GO:0001071 nucleic acid binding transcription factor activity
1.44 2.64e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
2.79 3.63e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
11.30 4.42e-02 GO:0035014 phosphatidylinositol 3-kinase regulator activity