Motif ID: HNF4A_NR2F1,2.p2

Z-value: 3.400


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_430298650.631.9e-25Click!
NR2F2chr15_+_96876568-0.291.1e-05Click!
NR2F1chr5_+_929189240.243.5e-04Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_42811959 42.392 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr16_+_222845 41.295 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr19_+_35629727 36.722 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr14_-_94855120 36.451 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31982538 35.634 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr22_+_23229959 35.111 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr14_-_24777184 34.151 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777160 33.593 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777153 33.130 CIDEB
cell death-inducing DFFA-like effector b
chr22_+_22569155 30.375


chr3_-_52479042 30.227 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr1_-_230849847 28.262 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr14_-_24777064 27.978


chr1_-_230849863 27.380 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr22_-_20104695 25.560 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr1_-_173886401 25.030 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_+_159593233 24.799 NM_004453
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr1_-_151345156 24.506 NM_003944
SELENBP1
selenium binding protein 1
chr17_-_34329083 24.493 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr9_+_74526527 23.907 C9orf85
chromosome 9 open reading frame 85
chr6_+_33172418 22.973 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_-_230850335 22.157 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_173886464 21.871 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_31913763 21.351 CFB
complement factor B
chr22_+_21986968 21.351 NM_152612
CCDC116
coiled-coil domain containing 116
chr19_-_48867149 20.891 NM_018273
TMEM143
transmembrane protein 143
chr22_-_51021255 20.823 CHKB
choline kinase beta
chr3_+_52812438 20.599 NM_001166434
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr3_-_9921933 20.566 NM_001199551
NM_001199552
CIDEC

cell death-inducing DFFA-like effector c

chr22_-_51021200 20.553 CHKB
choline kinase beta
chr1_-_204380903 20.369 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr16_+_56685810 20.202 NM_005947
MT1B
metallothionein 1B
chr6_+_31949800 20.181 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr17_-_26697224 20.154 VTN
vitronectin
chr19_-_1174257 20.110 SBNO2
strawberry notch homolog 2 (Drosophila)
chr12_+_53497273 19.799 NM_003578
SOAT2
sterol O-acyltransferase 2
chr14_-_94854910 19.127 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr22_-_51021337 18.877 NM_005198
CHKB
CHKB-CPT1B
choline kinase beta
CHKB-CPT1B readthrough (non-protein coding)
chr8_+_21916858 18.465 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr3_-_194072004 17.763 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr3_+_186383770 17.683 NM_000412
HRG
histidine-rich glycoprotein
chr3_+_186560462 17.674 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr11_+_46740736 17.470 NM_000506
F2
coagulation factor II (thrombin)
chr22_-_42526877 17.067 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

chr11_+_46740769 17.043 F2
coagulation factor II (thrombin)
chr16_+_226678 17.014 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr22_-_42526792 16.970 CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr3_+_9691184 16.752 MTMR14
myotubularin related protein 14
chr22_-_20104745 16.677 NM_022727
NM_182984
TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

chr20_+_56136136 16.550 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr17_-_34328530 16.532 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr3_+_9691198 16.436 MTMR14
myotubularin related protein 14
chr19_+_37288408 16.255 LOC284408
uncharacterized LOC284408
chr12_+_56114150 16.251 NM_001199771
NM_002905
RDH5

retinol dehydrogenase 5 (11-cis/9-cis)

chr19_-_1174263 16.217 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr19_+_50016490 16.046 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_+_668312 15.984 MYL5
myosin, light chain 5, regulatory
chr12_-_57351381 15.858 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr2_+_219646448 15.838 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr17_+_7531275 15.671 SHBG
sex hormone-binding globulin
chr17_+_27370155 15.595 PIPOX
pipecolic acid oxidase
chr11_-_6462129 15.505 NM_000613
HPX
hemopexin
chr22_-_51066460 15.497 NM_000487
NM_001085425
NM_001085426
NM_001085427
NM_001085428
ARSA




arylsulfatase A




chr11_-_76155704 15.453


chr17_-_34328607 15.259 CCL14-CCL15
CCL14-CCL15 readthrough
chr19_+_50016500 15.258 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_+_31926788 15.011 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr4_+_668250 14.965 MYL5
myosin, light chain 5, regulatory
chr11_-_116708334 14.921 NM_000039
APOA1
apolipoprotein A-I
chr9_+_88897112 14.750


chr17_+_7239847 14.698 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr19_-_45822841 14.650 CKM
creatine kinase, muscle
chr2_-_238499317 14.569 RAB17
RAB17, member RAS oncogene family
chr19_-_6720585 14.436 NM_000064
C3
complement component 3
chr6_+_31913852 14.422 CFB
complement factor B
chr6_+_31623688 14.361 APOM
apolipoprotein M
chr1_-_169555710 14.342 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr17_+_1665342 13.963 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_-_7125727 13.828 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr19_+_45445494 13.817 NM_001646
APOC4-APOC2
APOC4
APOC4-APOC2 readthrough
apolipoprotein C-IV
chr19_-_633474 13.777 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr12_+_113659216 13.616 NM_001143819
NM_017901
TPCN1

two pore segment channel 1

chr1_-_120311466 13.415 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr17_+_19437140 13.400 NM_018242
SLC47A1
solute carrier family 47, member 1
chr12_+_113659275 13.330 TPCN1
two pore segment channel 1
chr1_+_153330329 13.269 NM_002965
S100A9
S100 calcium binding protein A9
chr8_+_21916685 13.268 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr19_+_10197023 13.094 C19orf66
chromosome 19 open reading frame 66
chr3_-_50340979 13.018 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr13_+_113777112 12.987 NM_000504
F10
coagulation factor X
chr17_+_27369917 12.841 NM_016518
PIPOX
pipecolic acid oxidase
chr6_+_31623668 12.822 NM_019101
APOM
apolipoprotein M
chr19_+_50016606 12.769 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr20_-_43883183 12.766 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr9_+_140513443 12.674 NM_001145527
NM_024757
EHMT1

euchromatic histone-lysine N-methyltransferase 1

chr17_-_26697293 12.654 VTN
vitronectin
chr12_+_109273856 12.591 NM_001917
DAO
D-amino-acid oxidase
chr1_-_161193190 12.509 APOA2
apolipoprotein A-II
chr6_+_31913708 12.495 NM_001710
CFB
complement factor B
chr12_-_95467104 12.489 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr19_-_39390168 12.453 NM_012237
NM_001193286
NM_030593
SIRT2


sirtuin 2


chr20_+_57875481 12.450 NM_000114
NM_207032
NM_207033
NM_207034
EDN3



endothelin 3



chr7_-_129251465 12.445


chr6_-_32557431 12.383 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr16_-_55867016 12.381 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr9_+_34458810 12.353 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr22_-_20104428 12.263 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chrX_+_138612894 12.170 NM_000133
F9
coagulation factor IX
chr6_+_30594607 12.149 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr19_+_49956472 11.959 NM_001145396
NM_153329
ALDH16A1

aldehyde dehydrogenase 16 family, member A1

chr14_-_24768841 11.951 NM_001136050
DHRS1
dehydrogenase/reductase (SDR family) member 1
chr2_-_21266893 11.879 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_-_27389319 11.813 NM_014915
ANKRD26
ankyrin repeat domain 26
chr16_+_67840976 11.783 NM_018430
TSNAXIP1
translin-associated factor X interacting protein 1
chr5_-_149792276 11.754 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr3_+_186560478 11.716 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr17_+_41052813 11.673 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr12_+_10365415 11.630 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr12_+_121163570 11.629 NM_000017
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr1_-_169555624 11.601 F5
coagulation factor V (proaccelerin, labile factor)
chr22_+_24891114 11.584 NM_016327
UPB1
ureidopropionase, beta
chrX_+_38420690 11.467 NM_004615
TSPAN7
tetraspanin 7
chr3_+_42530790 11.402 NM_001251882
VIPR1
vasoactive intestinal peptide receptor 1
chr3_-_46904879 11.398 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr16_-_55866972 11.315 CES1
carboxylesterase 1
chr3_+_186330711 11.286 AHSG
alpha-2-HS-glycoprotein
chr4_-_120243257 11.271 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr1_-_36235422 11.213 NM_001190481
NM_022111
CLSPN

claspin

chr16_+_30710461 11.192 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr4_+_22694547 11.113 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr22_+_38453478 11.103 PICK1
protein interacting with PRKCA 1
chr6_+_43543877 11.091 NM_006502
POLH
polymerase (DNA directed), eta
chr2_+_219433302 11.045 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_-_238499713 10.970 NM_022449
RAB17
RAB17, member RAS oncogene family
chr1_-_113161724 10.920 NM_017744
NM_138727
NM_138728
NM_138729
ST7L



suppression of tumorigenicity 7 like



chr1_-_161193375 10.875 NM_001643
APOA2
apolipoprotein A-II
chr1_-_35325335 10.871 NM_001164825
NM_138428
C1orf212

chromosome 1 open reading frame 212

chr17_+_41006094 10.861 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr16_+_8768403 10.853 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr22_+_37257004 10.760 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr17_+_4854383 10.728 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr10_+_114133838 10.706 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_-_52687014 10.635 BCAS1
breast carcinoma amplified sequence 1
chr17_-_26697310 10.625 VTN
vitronectin
chr12_-_122296619 10.576 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr19_-_4342718 10.503 STAP2
signal transducing adaptor family member 2
chr15_+_85427891 10.502 NM_004213
NM_201651
SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr15_-_79382839 10.436 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr15_+_75105152 10.337 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr10_-_79789290 10.336 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr10_-_96829074 10.309 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr22_-_19512859 10.299 NM_001130861
NM_003277
CLDN5

claudin 5

chr22_-_19511777 10.273 CLDN5
claudin 5
chr12_+_58013692 10.273 NM_133489
SLC26A10
solute carrier family 26, member 10
chr13_+_52586516 10.208 NM_001004127
ALG11
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
chr16_-_16317290 10.179 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr19_-_40971623 10.175 NM_000713
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr6_+_31895401 10.164 C2
complement component 2
chr22_-_31686707 10.159 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr12_+_53443834 10.145 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr19_+_2328628 10.129 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr1_+_6845381 10.025 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr22_-_24059502 10.020 GUSBP11
glucuronidase, beta pseudogene 11
chr11_+_2924504 10.013 SLC22A18
solute carrier family 22, member 18
chr1_+_43855599 9.990 SZT2
seizure threshold 2 homolog (mouse)
chr4_-_10023094 9.985 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr2_+_3642421 9.976 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr4_-_72671236 9.956 NM_001204306
GC
group-specific component (vitamin D binding protein)
chr10_+_96698409 9.956 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr10_+_115310589 9.955 NM_001177660
HABP2
hyaluronan binding protein 2
chr12_-_8043743 9.897 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr1_+_6052357 9.897 NM_001199861
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr1_-_27952591 9.884 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr17_+_1665281 9.792 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_-_38806546 9.763 NM_001039672
NM_001039673
NM_001145463
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr19_+_2328679 9.752 SPPL2B
signal peptide peptidase-like 2B
chr6_+_31926580 9.732 NM_006929
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr17_+_1646290 9.695 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr17_+_1665306 9.687 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_9920633 9.682 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr10_+_114133775 9.640 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_155271186 9.595 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr17_+_37821598 9.581 NM_003673
TCAP
titin-cap (telethonin)
chr19_-_49339667 9.570 HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr8_-_132052834 9.544 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr10_+_88728187 9.535 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr11_+_66314373 9.512 NM_001104
ACTN3
actinin, alpha 3
chr19_+_47524142 9.494 NM_002517
NPAS1
neuronal PAS domain protein 1
chr7_+_150264457 9.472 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr10_+_102732285 9.457 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr16_+_56666533 9.446 NM_176870
MT1M
metallothionein 1M
chr19_+_39390570 9.359 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr22_+_25003610 9.349 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr5_-_149792370 9.283 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr9_+_140513451 9.279 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr13_+_113344354 9.245 NM_015205
NM_032189
ATP11A

ATPase, class VI, type 11A

chrX_-_70331297 9.201 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr19_-_633563 9.183 NM_005035
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr14_-_106174914 9.155 IGHA1
immunoglobulin heavy constant alpha 1
chr17_+_78518742 9.129 RPTOR
regulatory associated protein of MTOR, complex 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.14 1.25e-19 GO:0009987 cellular process
1.48 2.16e-15 GO:0042221 response to chemical stimulus
1.25 2.53e-15 GO:0050896 response to stimulus
1.34 4.53e-14 GO:0023052 signaling
1.65 8.07e-14 GO:0002376 immune system process
1.31 1.20e-13 GO:0051716 cellular response to stimulus
1.45 2.52e-12 GO:0065008 regulation of biological quality
1.34 4.60e-12 GO:0007165 signal transduction
1.18 8.93e-12 GO:0065007 biological regulation
1.73 1.55e-09 GO:0006955 immune response
1.44 3.38e-09 GO:0007166 cell surface receptor linked signaling pathway
1.43 4.95e-09 GO:0048583 regulation of response to stimulus
1.60 5.74e-08 GO:0070887 cellular response to chemical stimulus
1.15 3.32e-07 GO:0050789 regulation of biological process
1.66 7.44e-07 GO:0002682 regulation of immune system process
1.45 4.47e-06 GO:0010033 response to organic substance
1.67 5.77e-06 GO:0048878 chemical homeostasis
1.54 8.37e-06 GO:0009611 response to wounding
1.56 8.84e-06 GO:0006952 defense response
1.50 2.50e-05 GO:0006629 lipid metabolic process
1.55 3.28e-05 GO:0048584 positive regulation of response to stimulus
1.18 3.33e-05 GO:0032501 multicellular organismal process
1.28 1.07e-04 GO:0006950 response to stress
1.47 1.31e-04 GO:0009605 response to external stimulus
1.72 1.37e-04 GO:0002684 positive regulation of immune system process
1.40 1.63e-04 GO:0051239 regulation of multicellular organismal process
1.62 1.81e-04 GO:0050878 regulation of body fluid levels
1.14 1.91e-04 GO:0050794 regulation of cellular process
1.70 2.27e-04 GO:0050776 regulation of immune response
1.98 3.39e-04 GO:0008202 steroid metabolic process
1.13 5.90e-04 GO:0008152 metabolic process
1.43 9.11e-04 GO:0007154 cell communication
1.20 9.31e-04 GO:0032502 developmental process
1.21 1.06e-03 GO:0051179 localization
1.79 1.12e-03 GO:0032787 monocarboxylic acid metabolic process
1.50 1.25e-03 GO:0007267 cell-cell signaling
2.06 1.41e-03 GO:0003012 muscle system process
1.45 1.44e-03 GO:0042592 homeostatic process
2.10 1.60e-03 GO:0006936 muscle contraction
1.52 1.70e-03 GO:0009719 response to endogenous stimulus
1.62 1.79e-03 GO:0007599 hemostasis
1.35 2.09e-03 GO:0035556 intracellular signal transduction
1.79 2.27e-03 GO:0034097 response to cytokine stimulus
1.61 2.40e-03 GO:0007596 blood coagulation
1.61 2.40e-03 GO:0050817 coagulation
1.55 2.41e-03 GO:0042060 wound healing
1.54 2.56e-03 GO:0009725 response to hormone stimulus
2.84 2.73e-03 GO:0072376 protein activation cascade
1.62 2.86e-03 GO:0050801 ion homeostasis
1.21 3.27e-03 GO:0048856 anatomical structure development
1.92 3.34e-03 GO:0006631 fatty acid metabolic process
1.22 4.11e-03 GO:0048731 system development
1.79 5.05e-03 GO:0055065 metal ion homeostasis
1.28 5.48e-03 GO:0048513 organ development
1.80 6.39e-03 GO:0006875 cellular metal ion homeostasis
1.79 8.48e-03 GO:0048545 response to steroid hormone stimulus
1.19 1.02e-02 GO:0007275 multicellular organismal development
1.61 1.10e-02 GO:0006873 cellular ion homeostasis
1.49 1.37e-02 GO:0071310 cellular response to organic substance
1.31 1.45e-02 GO:0065009 regulation of molecular function
1.93 1.45e-02 GO:0006874 cellular calcium ion homeostasis
1.59 1.45e-02 GO:0055082 cellular chemical homeostasis
1.56 1.46e-02 GO:0001775 cell activation
1.40 1.72e-02 GO:0051704 multi-organism process
1.22 1.78e-02 GO:0048518 positive regulation of biological process
1.74 1.82e-02 GO:0006954 inflammatory response
1.82 1.87e-02 GO:0032101 regulation of response to external stimulus
2.04 2.16e-02 GO:0002252 immune effector process
1.68 2.24e-02 GO:0055080 cation homeostasis
1.53 2.25e-02 GO:0080134 regulation of response to stress
1.71 2.39e-02 GO:0030003 cellular cation homeostasis
1.20 2.75e-02 GO:0051234 establishment of localization
1.26 3.38e-02 GO:0044281 small molecule metabolic process
1.40 3.50e-02 GO:0040011 locomotion
1.20 3.63e-02 GO:0006810 transport
1.51 3.72e-02 GO:0051336 regulation of hydrolase activity
1.87 3.81e-02 GO:0055074 calcium ion homeostasis
1.87 3.81e-02 GO:0072503 cellular divalent inorganic cation homeostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.52 6.07e-19 GO:0044459 plasma membrane part
1.67 3.05e-16 GO:0005887 integral to plasma membrane
1.65 2.20e-15 GO:0031226 intrinsic to plasma membrane
1.69 6.57e-15 GO:0000267 cell fraction
1.76 2.82e-13 GO:0005626 insoluble fraction
1.74 3.47e-12 GO:0005624 membrane fraction
1.62 3.14e-08 GO:0005615 extracellular space
1.49 1.16e-06 GO:0044421 extracellular region part
1.21 4.19e-06 GO:0005886 plasma membrane
1.20 4.55e-06 GO:0071944 cell periphery
1.12 6.82e-06 GO:0005737 cytoplasm
1.15 2.32e-05 GO:0044444 cytoplasmic part
1.25 1.43e-03 GO:0005576 extracellular region
1.10 2.33e-03 GO:0016020 membrane
1.26 1.18e-02 GO:0012505 endomembrane system
1.34 1.58e-02 GO:0005794 Golgi apparatus
1.67 4.26e-02 GO:0005792 microsome
1.30 4.46e-02 GO:0005783 endoplasmic reticulum

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 2.46e-08 GO:0005488 binding
3.69 3.01e-06 GO:0019825 oxygen binding
2.43 7.19e-06 GO:0046906 tetrapyrrole binding
2.06 2.47e-05 GO:0005506 iron ion binding
2.41 2.96e-05 GO:0020037 heme binding
1.13 3.03e-05 GO:0005515 protein binding
4.22 4.54e-04 GO:0070330 aromatase activity
1.51 7.92e-04 GO:0046983 protein dimerization activity
2.53 1.47e-03 GO:0004497 monooxygenase activity
3.89 1.70e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
2.81 4.40e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.83 6.37e-03 GO:0003707 steroid hormone receptor activity
1.32 1.21e-02 GO:0005215 transporter activity
1.54 1.70e-02 GO:0042803 protein homodimerization activity
1.53 2.68e-02 GO:0008289 lipid binding
1.39 3.06e-02 GO:0042802 identical protein binding
1.22 3.63e-02 GO:0004871 signal transducer activity
1.22 3.63e-02 GO:0060089 molecular transducer activity