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• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: KLF4.p3

Z-value: 2.984

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr19_-_50143350	54.215	NM_006270	RRAS	related RAS viral (r-ras) oncogene homolog
chr12_-_109125275	54.109		CORO1C	coronin, actin binding protein, 1C
chr11_-_64014140	49.023		PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_109125289	48.163	NM_014325	CORO1C	coronin, actin binding protein, 1C
chr6_-_4135701	47.450	NM_001166010 NM_006117 NM_206836	ECI2	enoyl-CoA delta isomerase 2
chr4_-_71705545	45.598		GRSF1	G-rich RNA sequence binding factor 1
chrX_-_153599581	45.028		FLNA	filamin A, alpha
chr22_-_36784001	42.900		MYH9	myosin, heavy chain 9, non-muscle
chr12_-_109125254	41.934		CORO1C	coronin, actin binding protein, 1C
chrX_-_152989822	40.426	NM_005745	BCAP31	B-cell receptor-associated protein 31
chr8_+_26149080	37.354		PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr19_+_54695103	37.290	NM_001077446	TSEN34	tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chrX_-_152989851	36.965		BCAP31	B-cell receptor-associated protein 31
chr22_-_36783851	36.581		MYH9	myosin, heavy chain 9, non-muscle
chr11_-_64014264	36.175		PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_+_54694118	35.504	NM_024075	TSEN34	tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr11_-_64014407	34.763	NM_138689	PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr20_+_56884839	33.258		RAB22A	RAB22A, member RAS oncogene family
chr22_-_36783977	32.144		MYH9	myosin, heavy chain 9, non-muscle
chr11_+_65686908	31.868		DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)
chr11_-_64014381	31.775		PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_153599719	31.374		FLNA	filamin A, alpha
chr20_+_56885027	31.297		RAB22A	RAB22A, member RAS oncogene family
chrX_-_152989522	31.266	NM_001139457 NM_001139441	BCAP31	B-cell receptor-associated protein 31
chr20_+_56884749	30.136	NM_020673	RAB22A	RAB22A, member RAS oncogene family
chr15_+_90931470	29.924	NM_003870	IQGAP1	IQ motif containing GTPase activating protein 1
chr9_+_110045516	29.864	NM_002874	RAD23B	RAD23 homolog B (S. cerevisiae)
chr5_+_95998170	29.789		CAST	calpastatin
chr19_+_48828820	27.636		EMP3	epithelial membrane protein 3
chr8_+_26149004	26.953	NM_002717	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr22_+_43547526	26.558	NM_000714 NM_007311	TSPO	translocator protein (18kDa)
chr15_-_90777191	26.384	NM_006384	CIB1	calcium and integrin binding 1 (calmyrin)
chr6_-_31704093	26.375		CLIC1	chloride intracellular channel 1
chr4_-_103748966	26.368	NM_003340 NM_181886 NM_181888 NM_181889	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chrX_+_49028183	26.264	NM_002668	PLP2	proteolipid protein 2 (colonic epithelium-enriched)
chr4_-_103748254	25.915	NM_181892	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chr12_+_69004684	25.880		RAP1B	RAP1B, member of RAS oncogene family
chr2_+_85132999	25.836		TMSB10	thymosin beta 10
chr1_+_40506254	25.580	NM_001105530 NM_006367	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr22_-_36784055	25.395	NM_002473	MYH9	myosin, heavy chain 9, non-muscle
chr11_-_2950593	25.265	NM_003311	PHLDA2	pleckstrin homology-like domain, family A, member 2
chr12_+_69004710	25.250		RAP1B	RAP1B, member of RAS oncogene family
chr11_+_65686727	24.796	NM_006442	DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)
chr12_+_69004614	24.765	NM_001010942 NM_001251917 NM_001251918 NM_001251921 NM_001251922 NM_015646	RAP1B	RAP1B, member of RAS oncogene family
chr6_-_31704287	24.445		CLIC1	chloride intracellular channel 1
chr20_+_62371109	24.291	NM_020062	SLC2A4RG	SLC2A4 regulator
chrX_-_152989807	24.274
chr14_-_74960035	24.182	NM_006432	NPC2	Niemann-Pick disease, type C2
chr6_-_31704281	24.008		CLIC1	chloride intracellular channel 1
chr8_+_26149043	23.830		PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr1_+_65886130	23.710	NM_001198683 NM_017526	LEPROT	leptin receptor overlapping transcript
chr1_+_26606443	23.583		SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3
chr8_-_101962767	23.582	NM_001135702	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr19_+_50180492	23.355		PRMT1	protein arginine methyltransferase 1
chr1_-_33815411	23.262		PHC2	polyhomeotic homolog 2 (Drosophila)
chr12_+_120933911	23.047		DYNLL1	dynein, light chain, LC8-type 1
chr18_+_11981552	23.025		IMPA2	inositol(myo)-1(or 4)-monophosphatase 2
chr9_+_110045551	23.003		RAD23B	RAD23 homolog B (S. cerevisiae)
chr16_+_2564000	22.847		ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr17_-_4851688	22.334		PFN1	profilin 1
chr1_+_40506449	22.069		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr10_-_3214979	21.983	NM_001242307 NM_001242309 NM_014889	PITRM1	pitrilysin metallopeptidase 1
chrX_-_153775064	21.903	NM_000402	G6PD	glucose-6-phosphate dehydrogenase
chr2_+_235860616	21.733	NM_014521	SH3BP4	SH3-domain binding protein 4
chr1_-_152009467	21.668		S100A11	S100 calcium binding protein A11
chr18_+_11981421	21.570	NM_014214	IMPA2	inositol(myo)-1(or 4)-monophosphatase 2
chr19_+_48828627	21.403	NM_001425	EMP3	epithelial membrane protein 3
chr4_-_103748649	21.365	NM_181887 NM_181891	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chr6_-_86352982	21.283	NM_001159677 NM_006372	SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein
chr6_-_31704070	21.138		CLIC1	chloride intracellular channel 1
chr9_+_110045565	21.016		RAD23B	RAD23 homolog B (S. cerevisiae)
chr20_+_388717	20.917		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr20_+_388941	20.825		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr2_-_215674292	20.683	NM_000465	BARD1	BRCA1 associated RING domain 1
chr18_+_29671925	20.616		RNF138	ring finger protein 138
chr2_+_114647699	20.546		ACTR3	ARP3 actin-related protein 3 homolog (yeast)
chr10_+_120863558	20.487		FAM45A	family with sequence similarity 45, member A
chrX_-_153775427	20.352		G6PD	glucose-6-phosphate dehydrogenase
chr13_+_28196029	20.310		POLR1D	polymerase (RNA) I polypeptide D, 16kDa
chr1_+_40506423	20.212		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr10_-_3214963	20.173		PITRM1	pitrilysin metallopeptidase 1
chr20_+_43514340	20.085	NM_003404 NM_139323	YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr12_+_120933832	19.940	NM_001037495 NM_003746	DYNLL1	dynein, light chain, LC8-type 1
chr15_-_90777144	19.802		CIB1	calcium and integrin binding 1 (calmyrin)
chr17_+_45727274	19.792	NM_002265	KPNB1	karyopherin (importin) beta 1
chr20_+_62371218	19.581		SLC2A4RG	SLC2A4 regulator
chr1_+_182992329	19.571	NM_002293	LAMC1	laminin, gamma 1 (formerly LAMB2)
chr1_+_40506436	19.315		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr3_+_38207247	19.162		OXSR1	oxidative-stress responsive 1
chrX_+_118708540	19.111		UBE2A	ubiquitin-conjugating enzyme E2A
chr8_-_101965194	19.109	NM_001135699	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_40506384	18.988		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr3_+_38206968	18.945	NM_005109	OXSR1	oxidative-stress responsive 1
chr22_+_43547558	18.943		TSPO	translocator protein (18kDa)
chr7_+_116166346	18.888	NM_001172896 NM_001172897	CAV1	caveolin 1, caveolae protein, 22kDa
chr10_-_126849556	18.767	NM_001083914	CTBP2	C-terminal binding protein 2
chr2_+_242255365	18.692		SEPT2	septin 2
chr1_-_205719157	18.571		NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1
chr3_+_50273745	18.554		GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_+_40506406	18.519		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr14_+_105941061	18.367	NM_001312	CRIP2	cysteine-rich protein 2
chr15_-_60690115	18.268	NM_001002857 NM_001002858 NM_001136015 NM_004039	ANXA2	annexin A2
chr10_+_82213892	18.160	NM_001128309 NM_030927	TSPAN14	tetraspanin 14
chr1_+_87170515	17.944		SH3GLB1	SH3-domain GRB2-like endophilin B1
chr2_+_238600878	17.905		LRRFIP1	leucine rich repeat (in FLII) interacting protein 1
chr12_+_53342842	17.800	NM_000224	KRT18	keratin 18
chr3_-_33481862	17.631	NM_001128160 NM_014517	UBP1	upstream binding protein 1 (LBP-1a)
chr10_-_3214907	17.573		PITRM1	pitrilysin metallopeptidase 1
chr1_-_151966303	17.468		S100A10	S100 calcium binding protein A10
chr17_-_62658175	17.455		SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr6_-_7313352	17.453	NM_003144	SSR1	signal sequence receptor, alpha
chr20_+_43514350	17.417		YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr14_-_35099296	17.208	NM_021249 NM_152233	SNX6	sorting nexin 6
chr3_+_49711751	17.206		APEH	N-acylaminoacyl-peptide hydrolase
chr6_-_159065739	17.168	NM_006519	DYNLT1	dynein, light chain, Tctex-type 1
chr19_-_50432952	17.161	NM_016553	NUP62	nucleoporin 62kDa
chr9_-_113018711	17.097		TXN	thioredoxin
chr1_-_151966713	17.086	NM_002966	S100A10	S100 calcium binding protein A10
chr18_+_3449972	17.074	NM_173209 NM_173208 NM_003244	TGIF1	TGFB-induced factor homeobox 1
chr11_-_67188614	17.064		PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme
chr19_-_33166057	16.989	NM_032139	ANKRD27	ankyrin repeat domain 27 (VPS9 domain)
chr19_+_50180408	16.949	NM_001207042 NM_001536 NM_198318	PRMT1	protein arginine methyltransferase 1
chr22_+_24951617	16.935	NM_004175	SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr2_-_37899227	16.811	NM_006449	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chr14_-_74960003	16.707		NPC2	Niemann-Pick disease, type C2
chrX_+_64887510	16.602	NM_002444	MSN	moesin
chr5_+_95998678	16.491		CAST	calpastatin
chr1_-_113249677	16.447	NM_001042679	RHOC	ras homolog gene family, member C
chr4_-_71705613	16.405	NM_002092	GRSF1	G-rich RNA sequence binding factor 1
chr11_-_66234176	16.362		MRPL11	mitochondrial ribosomal protein L11
chr9_-_113018802	16.325		TXN	thioredoxin
chr19_-_42806460	16.280	NM_002573	PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr18_-_51750934	16.257		MBD2	methyl-CpG binding domain protein 2
chr1_+_26606621	16.253		SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3
chr14_-_74959976	16.213		NPC2	Niemann-Pick disease, type C2
chr15_+_90931449	16.206		IQGAP1	IQ motif containing GTPase activating protein 1
chr22_-_19166133	16.070		SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_-_33815340	16.042		PHC2	polyhomeotic homolog 2 (Drosophila)
chr13_+_32420828	16.041		EEF1DP3	eukaryotic translation elongation factor 1 delta pseudogene 3
chr4_-_39529099	16.011	NM_001184700 NM_001184701 NM_003359	UGDH	UDP-glucose 6-dehydrogenase
chr8_-_124428589	16.005		ATAD2	ATPase family, AAA domain containing 2
chr11_+_64009587	15.963	NM_057092	FKBP2	FK506 binding protein 2, 13kDa
chr6_+_31633656	15.921	NM_001320	CSNK2B	casein kinase 2, beta polypeptide
chr1_-_1822501	15.879		GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1
chr1_-_222885653	15.820	NM_022831	AIDA	axin interactor, dorsalization associated
chr11_-_64645925	15.719		EHD1	EH-domain containing 1
chr1_-_205719340	15.684	NM_022731	NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_+_10353980	15.595
chr8_+_98656428	15.534		MTDH	metadherin
chr19_+_6739697	15.518	NM_004240	TRIP10	thyroid hormone receptor interactor 10
chr12_+_6875686	15.441		PTMS	parathymosin
chr18_-_9614555	15.234	NM_001042388 NM_005134	PPP4R1	protein phosphatase 4, regulatory subunit 1
chr12_+_6875468	15.169	NM_002824	PTMS	parathymosin
chr2_-_32235603	15.097	NM_001137602 NM_015955	MEMO1	mediator of cell motility 1
chr10_+_75757847	15.085	NM_003373 NM_014000	VCL	vinculin
chr17_-_62658311	15.014	NM_022739	SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr2_+_85198431	15.011		KCMF1	potassium channel modulatory factor 1
chr12_+_53342899	14.947		KRT18	keratin 18
chr3_+_50273645	14.921	NM_002070	GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr18_-_9614454	14.906		PPP4R1	protein phosphatase 4, regulatory subunit 1
chr4_-_39528921	14.861		UGDH	UDP-glucose 6-dehydrogenase
chr7_+_26241372	14.861		CBX3	chromobox homolog 3
chr22_+_41347328	14.777	NM_014248	RBX1	ring-box 1, E3 ubiquitin protein ligase
chr3_+_52719935	14.720	NM_014366 NM_206825 NM_206826	GNL3	guanine nucleotide binding protein-like 3 (nucleolar)
chr17_-_66453561	14.692	NM_017983	WIPI1	WD repeat domain, phosphoinositide interacting 1
chr10_+_120863626	14.666		FAM45A FAM45B	family with sequence similarity 45, member A family with sequence similarity 45, member A pseudogene
chr22_+_39898365	14.658		SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like
chr10_+_70883856	14.648	NM_001035260 NM_004896	VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr20_+_32581725	14.591		RALY	RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr2_-_10588451	14.578	NM_002539	ODC1	ornithine decarboxylase 1
chr2_-_37898768	14.556		CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chrX_+_64887534	14.555		MSN	moesin
chr2_-_220252627	14.547	NM_012100	DNPEP	aspartyl aminopeptidase
chr7_+_116139619	14.523	NM_001206747 NM_001233 NM_198212	CAV2	caveolin 2
chr6_+_30689414	14.517		TUBB	tubulin, beta class I
chr17_+_76164624	14.511	NM_004710	SYNGR2	synaptogyrin 2
chr15_+_75074714	14.444		CSK	c-src tyrosine kinase
chr10_+_70883930	14.432		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr4_-_2935851	14.423	NM_001120	MFSD10	major facilitator superfamily domain containing 10
chr1_+_193028598	14.412		TROVE2	TROVE domain family, member 2
chr2_-_10588273	14.391		ODC1	ornithine decarboxylase 1
chr12_+_120933916	14.357		DYNLL1	dynein, light chain, LC8-type 1
chr7_-_94285372	14.316		SGCE	sarcoglycan, epsilon
chr1_-_153508463	14.302		S100A6	S100 calcium binding protein A6
chr7_-_94285426	14.283		SGCE	sarcoglycan, epsilon
chr12_-_56122800	14.241		CD63	CD63 molecule
chr1_-_151966276	14.227		S100A10	S100 calcium binding protein A10
chr5_+_137673953	14.197		FAM53C	family with sequence similarity 53, member C
chr1_-_54411245	14.189	NM_016126	HSPB11	heat shock protein family B (small), member 11
chr21_-_45196149	14.181		CSTB	cystatin B (stefin B)
chr1_-_183604793	14.127		ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa
chr17_+_75277491	14.121	NM_001113491	SEPT9	septin 9
chr16_-_75529278	14.098
chr19_+_14544216	14.092		PKN1	protein kinase N1
chr7_-_105925329	14.058		NAMPT	nicotinamide phosphoribosyltransferase
chr2_+_27651483	13.896		NRBP1	nuclear receptor binding protein 1
chr19_-_48894615	13.894		KDELR1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr9_-_111775721	13.872	NM_003798	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1
chrX_+_106871739	13.859		PRPS1	phosphoribosyl pyrophosphate synthetase 1
chr18_+_29672568	13.839	NM_001191324 NM_198128	RNF138	ring finger protein 138

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.17	3.44e-83	GO:0009987	cellular process
1.27	3.88e-57	GO:0044237	cellular metabolic process
1.22	2.33e-50	GO:0008152	metabolic process
1.24	6.17e-46	GO:0044238	primary metabolic process
1.29	2.26e-39	GO:0044260	cellular macromolecule metabolic process
1.18	5.60e-38	GO:0065007	biological regulation
1.25	7.25e-36	GO:0043170	macromolecule metabolic process
1.18	5.22e-33	GO:0050789	regulation of biological process
1.31	3.18e-31	GO:0006807	nitrogen compound metabolic process
1.18	8.11e-30	GO:0050794	regulation of cellular process
1.30	8.07e-29	GO:0034641	cellular nitrogen compound metabolic process
1.32	2.19e-27	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27	6.46e-24	GO:0016043	cellular component organization
1.26	7.42e-23	GO:0071840	cellular component organization or biogenesis
1.30	1.82e-22	GO:0048518	positive regulation of biological process
1.31	3.53e-21	GO:0048522	positive regulation of cellular process
1.33	1.29e-20	GO:0048523	negative regulation of cellular process
1.22	1.12e-19	GO:0051716	cellular response to stimulus
1.30	2.05e-19	GO:0048519	negative regulation of biological process
1.29	8.35e-18	GO:0044249	cellular biosynthetic process
1.28	1.16e-17	GO:0044267	cellular protein metabolic process
1.27	2.35e-17	GO:0071842	cellular component organization at cellular level
1.28	3.07e-17	GO:0009058	biosynthetic process
1.45	3.76e-17	GO:0042981	regulation of apoptosis
1.30	5.68e-17	GO:0090304	nucleic acid metabolic process
1.45	7.39e-17	GO:0043067	regulation of programmed cell death
1.44	2.17e-16	GO:0010941	regulation of cell death
1.26	3.22e-16	GO:0071841	cellular component organization or biogenesis at cellular level
1.34	1.05e-15	GO:0006996	organelle organization
1.22	1.67e-15	GO:0007165	signal transduction
1.20	2.36e-15	GO:0019222	regulation of metabolic process
1.30	2.47e-15	GO:0043412	macromolecule modification
1.31	2.59e-15	GO:0006464	protein modification process
1.40	3.59e-15	GO:0010604	positive regulation of macromolecule metabolic process
1.20	3.66e-15	GO:0023052	signaling
1.38	8.96e-15	GO:0009893	positive regulation of metabolic process
1.23	2.37e-14	GO:0019538	protein metabolic process
1.31	2.48e-14	GO:0044281	small molecule metabolic process
1.46	2.57e-14	GO:0008219	cell death
1.45	6.90e-14	GO:0016265	death
1.20	1.05e-13	GO:0031323	regulation of cellular metabolic process
1.27	2.08e-13	GO:0065008	regulation of biological quality
1.20	3.06e-13	GO:0080090	regulation of primary metabolic process
1.37	6.19e-13	GO:0031325	positive regulation of cellular metabolic process
1.30	6.98e-13	GO:0009059	macromolecule biosynthetic process
1.26	1.18e-12	GO:0042221	response to chemical stimulus
1.30	1.43e-12	GO:0034645	cellular macromolecule biosynthetic process
1.24	2.17e-12	GO:0006950	response to stress
1.32	4.98e-12	GO:0009056	catabolic process
1.28	5.58e-12	GO:0010467	gene expression
1.20	6.62e-12	GO:0060255	regulation of macromolecule metabolic process
1.18	7.51e-12	GO:0032502	developmental process
1.29	7.71e-12	GO:0016070	RNA metabolic process
1.34	8.74e-12	GO:0051641	cellular localization
1.36	9.18e-12	GO:0044248	cellular catabolic process
1.13	1.81e-11	GO:0050896	response to stimulus
1.43	3.80e-11	GO:0046907	intracellular transport
1.45	5.00e-11	GO:0012501	programmed cell death
1.45	1.05e-10	GO:0006915	apoptosis
1.37	2.07e-10	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.32	2.23e-10	GO:0033036	macromolecule localization
1.18	3.54e-10	GO:0007275	multicellular organismal development
1.19	9.02e-10	GO:0048856	anatomical structure development
1.18	1.20e-09	GO:0051179	localization
1.50	3.31e-09	GO:0043065	positive regulation of apoptosis
1.50	3.73e-09	GO:0043068	positive regulation of programmed cell death
1.38	6.71e-09	GO:0051128	regulation of cellular component organization
1.43	8.48e-09	GO:0046483	heterocycle metabolic process
1.53	9.51e-09	GO:0072521	purine-containing compound metabolic process
1.32	1.41e-08	GO:0051649	establishment of localization in cell
1.30	1.50e-08	GO:0010033	response to organic substance
1.48	1.56e-08	GO:0010942	positive regulation of cell death
1.32	1.62e-08	GO:0051246	regulation of protein metabolic process
1.19	2.12e-08	GO:0051171	regulation of nitrogen compound metabolic process
1.34	2.93e-08	GO:0009892	negative regulation of metabolic process
1.34	3.44e-08	GO:0042127	regulation of cell proliferation
1.35	3.80e-08	GO:0031324	negative regulation of cellular metabolic process
1.33	4.06e-08	GO:0032268	regulation of cellular protein metabolic process
1.45	4.10e-08	GO:0055086	nucleobase, nucleoside and nucleotide metabolic process
1.53	4.39e-08	GO:0051247	positive regulation of protein metabolic process
1.33	5.76e-08	GO:0007049	cell cycle
1.51	5.93e-08	GO:0043069	negative regulation of programmed cell death
1.41	7.67e-08	GO:0007167	enzyme linked receptor protein signaling pathway
1.34	7.93e-08	GO:0070887	cellular response to chemical stimulus
1.51	8.04e-08	GO:0043066	negative regulation of apoptosis
1.37	8.26e-08	GO:0051173	positive regulation of nitrogen compound metabolic process
1.49	9.59e-08	GO:0060548	negative regulation of cell death
1.34	1.21e-07	GO:0010605	negative regulation of macromolecule metabolic process
1.46	1.42e-07	GO:0006753	nucleoside phosphate metabolic process
1.46	1.42e-07	GO:0009117	nucleotide metabolic process
1.31	1.43e-07	GO:0008104	protein localization
1.35	1.67e-07	GO:0006351	transcription, DNA-dependent
1.36	1.70e-07	GO:0033554	cellular response to stress
1.52	1.70e-07	GO:0006163	purine nucleotide metabolic process
1.18	2.65e-07	GO:0048731	system development
1.37	2.69e-07	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.54	3.30e-07	GO:0016568	chromatin modification
1.49	4.48e-07	GO:0008285	negative regulation of cell proliferation
1.39	4.88e-07	GO:0010628	positive regulation of gene expression
1.40	5.69e-07	GO:0051726	regulation of cell cycle
1.17	7.94e-07	GO:0051234	establishment of localization
1.40	8.67e-07	GO:0009725	response to hormone stimulus
1.18	9.10e-07	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51	9.60e-07	GO:0032270	positive regulation of cellular protein metabolic process
1.63	1.07e-06	GO:0072523	purine-containing compound catabolic process
1.38	1.28e-06	GO:0051254	positive regulation of RNA metabolic process
1.40	1.42e-06	GO:0051276	chromosome organization
1.45	1.52e-06	GO:0006325	chromatin organization
1.17	1.62e-06	GO:0006810	transport
1.63	1.69e-06	GO:0006195	purine nucleotide catabolic process
1.23	1.96e-06	GO:0023051	regulation of signaling
1.32	2.17e-06	GO:0050793	regulation of developmental process
1.18	2.21e-06	GO:0031326	regulation of cellular biosynthetic process
1.18	2.48e-06	GO:0010468	regulation of gene expression
1.29	2.73e-06	GO:0022607	cellular component assembly
1.53	2.79e-06	GO:0009259	ribonucleotide metabolic process
1.38	2.98e-06	GO:0071310	cellular response to organic substance
1.30	3.25e-06	GO:0032774	RNA biosynthetic process
1.34	3.25e-06	GO:0031399	regulation of protein modification process
1.27	3.30e-06	GO:0002376	immune system process
1.55	3.38e-06	GO:0031401	positive regulation of protein modification process
1.42	3.42e-06	GO:0044282	small molecule catabolic process
1.30	3.61e-06	GO:0006793	phosphorus metabolic process
1.30	3.61e-06	GO:0006796	phosphate metabolic process
1.19	3.79e-06	GO:0051252	regulation of RNA metabolic process
1.42	3.81e-06	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.40	4.39e-06	GO:0000278	mitotic cell cycle
1.25	4.42e-06	GO:0035556	intracellular signal transduction
1.43	4.58e-06	GO:0007599	hemostasis
1.40	5.05e-06	GO:0050878	regulation of body fluid levels
1.17	7.24e-06	GO:0009889	regulation of biosynthetic process
1.50	8.20e-06	GO:0018193	peptidyl-amino acid modification
1.36	9.09e-06	GO:0045595	regulation of cell differentiation
1.74	9.35e-06	GO:0031400	negative regulation of protein modification process
1.23	9.59e-06	GO:0009653	anatomical structure morphogenesis
1.37	9.65e-06	GO:0045893	positive regulation of transcription, DNA-dependent
1.24	1.05e-05	GO:0065009	regulation of molecular function
1.32	1.06e-05	GO:0031328	positive regulation of cellular biosynthetic process
1.20	1.14e-05	GO:0030154	cell differentiation
1.26	1.22e-05	GO:0044085	cellular component biogenesis
1.18	1.26e-05	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.36	1.36e-05	GO:0009719	response to endogenous stimulus
1.42	1.39e-05	GO:0007596	blood coagulation
1.42	1.39e-05	GO:0050817	coagulation
1.33	1.41e-05	GO:2000026	regulation of multicellular organismal development
1.19	1.80e-05	GO:0048869	cellular developmental process
1.51	1.89e-05	GO:0009150	purine ribonucleotide metabolic process
1.40	2.05e-05	GO:0070727	cellular macromolecule localization
1.24	2.14e-05	GO:0009966	regulation of signal transduction
1.20	2.27e-05	GO:0048583	regulation of response to stimulus
1.31	2.32e-05	GO:0009891	positive regulation of biosynthetic process
1.49	2.39e-05	GO:0012502	induction of programmed cell death
1.30	2.47e-05	GO:0045184	establishment of protein localization
1.27	3.09e-05	GO:0010646	regulation of cell communication
1.48	3.60e-05	GO:0006917	induction of apoptosis
1.60	4.27e-05	GO:0009261	ribonucleotide catabolic process
1.53	4.44e-05	GO:0034655	nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.53	4.44e-05	GO:0034656	nucleobase, nucleoside and nucleotide catabolic process
1.25	4.51e-05	GO:0050790	regulation of catalytic activity
1.60	4.98e-05	GO:0009154	purine ribonucleotide catabolic process
1.36	5.30e-05	GO:0051172	negative regulation of nitrogen compound metabolic process
1.39	5.85e-05	GO:0034613	cellular protein localization
1.56	6.20e-05	GO:0051248	negative regulation of protein metabolic process
1.31	6.44e-05	GO:0022402	cell cycle process
1.36	7.84e-05	GO:0042060	wound healing
1.47	8.08e-05	GO:0010564	regulation of cell cycle process
1.50	8.09e-05	GO:0032870	cellular response to hormone stimulus
1.17	8.23e-05	GO:0010556	regulation of macromolecule biosynthetic process
1.54	8.34e-05	GO:0009166	nucleotide catabolic process
1.32	8.57e-05	GO:0010557	positive regulation of macromolecule biosynthetic process
1.35	8.79e-05	GO:0009057	macromolecule catabolic process
1.30	9.08e-05	GO:0015031	protein transport
1.22	9.23e-05	GO:0007399	nervous system development
1.80	9.77e-05	GO:0007265	Ras protein signal transduction
2.03	1.04e-04	GO:0031346	positive regulation of cell projection organization
1.49	1.06e-04	GO:0044270	cellular nitrogen compound catabolic process
1.35	1.09e-04	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39	1.10e-04	GO:0070271	protein complex biogenesis
1.53	1.27e-04	GO:0007346	regulation of mitotic cell cycle
1.41	1.33e-04	GO:0044262	cellular carbohydrate metabolic process
1.28	1.42e-04	GO:0009611	response to wounding
1.49	1.43e-04	GO:0046700	heterocycle catabolic process
1.50	1.48e-04	GO:0051130	positive regulation of cellular component organization
1.43	1.49e-04	GO:0006886	intracellular protein transport
1.58	1.51e-04	GO:0009203	ribonucleoside triphosphate catabolic process
1.58	1.51e-04	GO:0009207	purine ribonucleoside triphosphate catabolic process
1.30	1.73e-04	GO:0044093	positive regulation of molecular function
1.39	1.78e-04	GO:0006461	protein complex assembly
1.17	1.82e-04	GO:0006355	regulation of transcription, DNA-dependent
1.57	2.08e-04	GO:0009146	purine nucleoside triphosphate catabolic process
1.45	2.27e-04	GO:0044419	interspecies interaction between organisms
1.40	2.54e-04	GO:0061024	membrane organization
1.32	2.69e-04	GO:0022403	cell cycle phase
1.54	2.82e-04	GO:0032269	negative regulation of cellular protein metabolic process
1.40	2.92e-04	GO:0016044	cellular membrane organization
1.46	3.38e-04	GO:0045597	positive regulation of cell differentiation
1.48	3.94e-04	GO:0006366	transcription from RNA polymerase II promoter
1.36	4.09e-04	GO:0051253	negative regulation of RNA metabolic process
1.50	4.50e-04	GO:0048545	response to steroid hormone stimulus
1.55	5.26e-04	GO:0009143	nucleoside triphosphate catabolic process
1.31	6.21e-04	GO:0031327	negative regulation of cellular biosynthetic process
1.38	6.22e-04	GO:0006066	alcohol metabolic process
1.57	8.24e-04	GO:0044087	regulation of cellular component biogenesis
1.46	9.00e-04	GO:0051325	interphase
1.32	9.15e-04	GO:0005975	carbohydrate metabolic process
1.46	9.43e-04	GO:0051329	interphase of mitotic cell cycle
1.54	9.63e-04	GO:0005996	monosaccharide metabolic process
1.79	1.16e-03	GO:0010720	positive regulation of cell development
1.44	1.19e-03	GO:0071495	cellular response to endogenous stimulus
1.35	1.21e-03	GO:0006974	response to DNA damage stimulus
1.18	1.30e-03	GO:0007166	cell surface receptor linked signaling pathway
1.33	1.33e-03	GO:0071822	protein complex subunit organization
1.30	1.42e-03	GO:0065003	macromolecular complex assembly
1.46	1.47e-03	GO:0009199	ribonucleoside triphosphate metabolic process
1.22	1.50e-03	GO:0051239	regulation of multicellular organismal process
1.32	1.79e-03	GO:0006259	DNA metabolic process
1.30	2.05e-03	GO:0009890	negative regulation of biosynthetic process
1.57	2.06e-03	GO:0019318	hexose metabolic process
1.74	2.13e-03	GO:0042770	signal transduction in response to DNA damage
1.27	2.15e-03	GO:0043933	macromolecular complex subunit organization
1.46	2.17e-03	GO:0009205	purine ribonucleoside triphosphate metabolic process
1.45	2.40e-03	GO:0009144	purine nucleoside triphosphate metabolic process
1.34	2.43e-03	GO:0044265	cellular macromolecule catabolic process
1.87	3.04e-03	GO:0008629	induction of apoptosis by intracellular signals
1.29	3.04e-03	GO:0009790	embryo development
1.31	3.22e-03	GO:0010629	negative regulation of gene expression
1.33	3.46e-03	GO:0045892	negative regulation of transcription, DNA-dependent
1.36	3.54e-03	GO:0051094	positive regulation of developmental process
1.39	3.57e-03	GO:0007264	small GTPase mediated signal transduction
1.33	3.62e-03	GO:0016071	mRNA metabolic process
1.44	3.66e-03	GO:0009141	nucleoside triphosphate metabolic process
1.25	3.72e-03	GO:0051704	multi-organism process
1.30	3.81e-03	GO:0006396	RNA processing
1.51	4.04e-03	GO:0071156	regulation of cell cycle arrest
1.25	4.06e-03	GO:0022008	neurogenesis
1.24	4.23e-03	GO:0032879	regulation of localization
1.25	4.53e-03	GO:0055114	oxidation-reduction process
1.28	4.69e-03	GO:0006468	protein phosphorylation
1.28	5.10e-03	GO:0043085	positive regulation of catalytic activity
1.27	5.11e-03	GO:0071844	cellular component assembly at cellular level
1.42	5.94e-03	GO:0060284	regulation of cell development
1.26	6.01e-03	GO:0016310	phosphorylation
1.41	6.05e-03	GO:0033043	regulation of organelle organization
1.50	6.17e-03	GO:0048011	nerve growth factor receptor signaling pathway
1.25	6.89e-03	GO:0048699	generation of neurons
1.25	8.01e-03	GO:0042592	homeostatic process
1.27	8.04e-03	GO:0016192	vesicle-mediated transport
1.82	8.25e-03	GO:0048872	homeostasis of number of cells
1.29	8.52e-03	GO:0010558	negative regulation of macromolecule biosynthetic process
1.59	9.28e-03	GO:0046039	GTP metabolic process
1.28	9.44e-03	GO:0019220	regulation of phosphate metabolic process
1.28	9.44e-03	GO:0051174	regulation of phosphorus metabolic process
1.29	1.13e-02	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.66	1.18e-02	GO:0043254	regulation of protein complex assembly
1.28	1.19e-02	GO:0042325	regulation of phosphorylation
1.42	1.21e-02	GO:0008380	RNA splicing
1.61	1.23e-02	GO:0006184	GTP catabolic process
1.49	1.27e-02	GO:0045786	negative regulation of cell cycle
1.40	1.44e-02	GO:0032535	regulation of cellular component size
1.52	1.45e-02	GO:0006979	response to oxidative stress
1.49	1.47e-02	GO:0000075	cell cycle checkpoint
1.32	1.52e-02	GO:0007010	cytoskeleton organization
1.47	1.52e-02	GO:0051129	negative regulation of cellular component organization
1.50	1.57e-02	GO:0001701	in utero embryonic development
1.77	1.58e-02	GO:0030099	myeloid cell differentiation
1.59	1.72e-02	GO:0016311	dephosphorylation
1.37	1.83e-02	GO:0090066	regulation of anatomical structure size
1.71	2.08e-02	GO:0043523	regulation of neuron apoptosis
1.53	2.34e-02	GO:0006913	nucleocytoplasmic transport
1.31	2.41e-02	GO:0009308	amine metabolic process
1.40	2.49e-02	GO:0048285	organelle fission
1.36	2.70e-02	GO:0044271	cellular nitrogen compound biosynthetic process
1.44	2.75e-02	GO:0009100	glycoprotein metabolic process
1.79	2.77e-02	GO:0050769	positive regulation of neurogenesis
1.35	2.80e-02	GO:0009968	negative regulation of signal transduction
1.27	2.93e-02	GO:0030030	cell projection organization
1.35	2.95e-02	GO:0006397	mRNA processing
1.35	2.95e-02	GO:0010627	regulation of intracellular protein kinase cascade
1.35	3.28e-02	GO:0006091	generation of precursor metabolites and energy
1.27	3.69e-02	GO:0001932	regulation of protein phosphorylation
1.47	3.88e-02	GO:0006916	anti-apoptosis
1.51	4.11e-02	GO:0051169	nuclear transport
1.31	4.16e-02	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.86	4.36e-02	GO:0030518	steroid hormone receptor signaling pathway
1.21	4.39e-02	GO:0009605	response to external stimulus
1.32	4.51e-02	GO:0010648	negative regulation of cell communication

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.15	1.44e-68	GO:0044424	intracellular part
1.22	1.63e-67	GO:0005737	cytoplasm
1.14	3.03e-63	GO:0005622	intracellular
1.17	3.09e-46	GO:0043227	membrane-bounded organelle
1.15	4.14e-46	GO:0043226	organelle
1.17	1.45e-45	GO:0043231	intracellular membrane-bounded organelle
1.24	1.94e-45	GO:0044444	cytoplasmic part
1.15	5.01e-45	GO:0043229	intracellular organelle
1.42	1.11e-35	GO:0005829	cytosol
1.22	6.32e-35	GO:0044446	intracellular organelle part
1.22	6.59e-35	GO:0044422	organelle part
1.35	5.32e-26	GO:0044428	nuclear part
1.19	3.96e-25	GO:0005634	nucleus
1.33	2.48e-23	GO:0070013	intracellular organelle lumen
1.32	5.63e-23	GO:0031974	membrane-enclosed lumen
1.32	1.18e-22	GO:0043233	organelle lumen
1.42	4.08e-21	GO:0005654	nucleoplasm
1.34	2.49e-19	GO:0031981	nuclear lumen
1.21	1.30e-15	GO:0032991	macromolecular complex
1.22	5.34e-14	GO:0043234	protein complex
1.28	9.78e-11	GO:0012505	endomembrane system
1.32	8.08e-10	GO:0000267	cell fraction
1.35	8.74e-09	GO:0005626	insoluble fraction
1.38	1.17e-08	GO:0044451	nucleoplasm part
1.03	1.67e-08	GO:0044464	cell part
1.03	1.84e-08	GO:0005623	cell
1.21	2.00e-08	GO:0031090	organelle membrane
1.31	4.21e-08	GO:0005794	Golgi apparatus
1.33	4.25e-07	GO:0005624	membrane fraction
1.25	1.88e-05	GO:0005783	endoplasmic reticulum
1.44	2.68e-05	GO:0048471	perinuclear region of cytoplasm
1.48	3.50e-05	GO:0015629	actin cytoskeleton
1.15	4.35e-05	GO:0043228	non-membrane-bounded organelle
1.15	4.35e-05	GO:0043232	intracellular non-membrane-bounded organelle
1.61	1.49e-04	GO:0070161	anchoring junction
1.64	2.16e-04	GO:0005912	adherens junction
2.81	5.78e-04	GO:0030530	heterogeneous nuclear ribonucleoprotein complex
1.30	1.36e-03	GO:0005694	chromosome
1.25	1.38e-03	GO:0031982	vesicle
1.26	1.71e-03	GO:0044432	endoplasmic reticulum part
1.19	1.75e-03	GO:0005739	mitochondrion
1.47	1.90e-03	GO:0016604	nuclear body
1.45	2.12e-03	GO:0005635	nuclear envelope
1.25	2.44e-03	GO:0031410	cytoplasmic vesicle
1.26	2.57e-03	GO:0031967	organelle envelope
1.86	2.59e-03	GO:0034399	nuclear periphery
1.74	2.65e-03	GO:0016585	chromatin remodeling complex
1.26	2.83e-03	GO:0031975	envelope
1.17	3.06e-03	GO:0005856	cytoskeleton
1.32	3.64e-03	GO:0044427	chromosomal part
1.44	4.20e-03	GO:0000785	chromatin
1.32	5.09e-03	GO:0005768	endosome
1.24	5.96e-03	GO:0031988	membrane-bounded vesicle
1.66	9.70e-03	GO:0005925	focal adhesion
1.24	9.99e-03	GO:0016023	cytoplasmic membrane-bounded vesicle
1.27	1.00e-02	GO:0044431	Golgi apparatus part
1.84	1.18e-02	GO:0016363	nuclear matrix
1.61	1.79e-02	GO:0030055	cell-substrate junction
2.01	2.15e-02	GO:0008287	protein serine/threonine phosphatase complex
2.03	2.34e-02	GO:0000118	histone deacetylase complex
1.24	2.37e-02	GO:0005789	endoplasmic reticulum membrane
1.61	2.44e-02	GO:0005924	cell-substrate adherens junction
1.23	3.04e-02	GO:0015630	microtubule cytoskeleton
1.94	3.55e-02	GO:0017053	transcriptional repressor complex
1.23	3.69e-02	GO:0042175	nuclear membrane-endoplasmic reticulum network

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.29	1.46e-90	GO:0005515	protein binding
1.14	1.31e-65	GO:0005488	binding
1.52	4.57e-17	GO:0019899	enzyme binding
1.25	1.01e-13	GO:0000166	nucleotide binding
1.46	2.85e-11	GO:0046983	protein dimerization activity
1.13	3.94e-11	GO:0003824	catalytic activity
1.25	2.12e-10	GO:0017076	purine nucleotide binding
1.25	3.59e-10	GO:0035639	purine ribonucleoside triphosphate binding
1.24	5.56e-10	GO:0032553	ribonucleotide binding
1.24	5.56e-10	GO:0032555	purine ribonucleotide binding
1.34	1.39e-06	GO:0042802	identical protein binding
1.47	1.98e-06	GO:0000988	protein binding transcription factor activity
1.47	1.98e-06	GO:0000989	transcription factor binding transcription factor activity
1.44	2.36e-06	GO:0019904	protein domain specific binding
1.47	2.96e-06	GO:0003712	transcription cofactor activity
1.31	3.57e-06	GO:0003723	RNA binding
1.22	3.66e-06	GO:0030554	adenyl nucleotide binding
1.22	8.85e-06	GO:0005524	ATP binding
1.22	1.09e-05	GO:0032559	adenyl ribonucleotide binding
1.39	1.46e-04	GO:0042803	protein homodimerization activity
1.54	4.34e-04	GO:0003924	GTPase activity
1.50	6.19e-04	GO:0046982	protein heterodimerization activity
1.24	1.34e-03	GO:0016772	transferase activity, transferring phosphorus-containing groups
1.84	1.45e-03	GO:0031625	ubiquitin protein ligase binding
1.25	2.58e-03	GO:0016301	kinase activity
1.25	7.88e-03	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.16	9.42e-03	GO:0016740	transferase activity
1.35	1.05e-02	GO:0005525	GTP binding
1.34	1.76e-02	GO:0019001	guanyl nucleotide binding
1.34	1.76e-02	GO:0032561	guanyl ribonucleotide binding
1.28	2.07e-02	GO:0008092	cytoskeletal protein binding
1.23	2.16e-02	GO:0017111	nucleoside-triphosphatase activity
1.20	2.74e-02	GO:0005102	receptor binding
1.43	2.92e-02	GO:0003713	transcription coactivator activity
1.53	3.15e-02	GO:0003714	transcription corepressor activity
1.45	3.32e-02	GO:0010843	promoter binding
1.50	3.42e-02	GO:0004721	phosphoprotein phosphatase activity
1.44	3.46e-02	GO:0000975	regulatory region DNA binding
1.44	3.46e-02	GO:0001067	regulatory region nucleic acid binding
1.44	3.46e-02	GO:0044212	transcription regulatory region DNA binding
1.40	4.37e-02	GO:0019900	kinase binding