Motif ID: MSX1,2.p2

Z-value: 1.442


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX2chr5_+_1741515310.381.0e-08Click!
MSX1chr4_+_48613710.028.2e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_238322840 42.753 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_238322770 39.764 COL6A3
collagen, type VI, alpha 3
chr2_-_238322815 35.995 COL6A3
collagen, type VI, alpha 3
chr4_+_88896801 30.049 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr4_+_88896838 29.895 SPP1
secreted phosphoprotein 1
chr18_+_21572736 29.010 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr4_+_88896868 28.518 SPP1
secreted phosphoprotein 1
chr4_+_88896899 26.273 SPP1
secreted phosphoprotein 1
chr9_-_116840551 24.839 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_116840460 17.395 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_116840604 15.913 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_7745354 14.412 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 13.829 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_-_160279045 13.632 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_+_15500288 12.536 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr16_-_75498582 12.109 NM_145254
TMEM170A
transmembrane protein 170A
chr17_-_15168590 12.103 NM_000304
PMP22
peripheral myelin protein 22
chr5_+_140810181 11.404 PCDHGA12
protocadherin gamma subfamily A, 12
chr9_-_116840545 10.332 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_-_66951381 9.566 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_-_195310985 9.115 NM_001647
APOD
apolipoprotein D
chr11_-_115088628 8.882 CADM1
cell adhesion molecule 1
chr3_-_149095458 8.058 TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095517 8.031 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr5_+_140810126 7.737 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr1_+_196788860 7.607 NM_002113
CFHR1
complement factor H-related 1
chr14_+_23305816 7.566 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr10_+_7745341 7.526 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr16_+_66400524 7.490 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_+_69812620 7.462 NM_001184967
MITF
microphthalmia-associated transcription factor
chr14_+_23305792 7.402 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_+_22979681 7.402 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr10_+_7745284 6.992 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_52828783 6.878 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr3_+_69812961 6.794 NM_006722
MITF
microphthalmia-associated transcription factor
chr9_-_116840673 6.559 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr5_-_42811959 6.545 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_-_165555167 6.374 BCHE
butyrylcholinesterase
chr11_-_59383616 5.886 NM_002556
OSBP
oxysterol binding protein
chr3_+_25470067 5.823 RARB
retinoic acid receptor, beta
chr10_-_45474210 5.780 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr17_+_41857802 5.703 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr17_-_64225496 5.433 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_+_100238063 5.361 TMEM45A
transmembrane protein 45A
chr10_+_49609641 5.327 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr10_+_124320180 5.241 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr1_-_104239071 5.132 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr11_+_117070039 5.130 NM_001001522
NM_003186
TAGLN

transgelin

chr16_+_56485435 5.076 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr12_+_32654976 5.058 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr21_-_37852387 4.944 NM_001146079
NM_144492
CLDN14

claudin 14

chr13_+_102104941 4.908 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr16_+_56485423 4.836 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr12_+_51318743 4.814 METTL7A
methyltransferase like 7A
chr4_+_71296208 4.781 NM_001145006
MUC7
mucin 7, secreted
chr3_-_165555252 4.756 NM_000055
BCHE
butyrylcholinesterase
chr4_+_71062241 4.644 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr3_-_149095333 4.555 TM4SF1
transmembrane 4 L six family member 1
chr4_+_71337833 4.458 NM_152291
MUC7
mucin 7, secreted
chr1_+_196621007 4.371 NM_000186
NM_001014975
CFH

complement factor H

chr1_+_104198140 4.339 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr3_-_149095413 4.191 TM4SF1
transmembrane 4 L six family member 1
chr11_-_8832881 4.104 NM_139157
ST5
suppression of tumorigenicity 5
chr1_+_33004771 4.047 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr4_+_155484131 3.942 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr9_-_97356007 3.872 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr19_-_17375522 3.795 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr3_+_186383770 3.791 NM_000412
HRG
histidine-rich glycoprotein
chr12_+_7169192 3.764


chr11_+_7618416 3.735 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_150978879 3.700 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr4_+_71337674 3.675 NM_001145007
MUC7
mucin 7, secreted
chr1_+_201979747 3.628 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr16_+_89984286 3.622 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chrX_-_15620191 3.547 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr9_+_120466625 3.529 TLR4
toll-like receptor 4
chr4_-_186733372 3.499 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr12_+_71833518 3.426 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr10_+_7745229 3.402 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_196912910 3.371 NM_005666
CFHR2
complement factor H-related 2
chr14_+_21756135 3.328 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr12_-_16759733 3.324 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_83393436 3.177 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr1_+_15764934 3.100 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr2_+_84743576 3.063 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chr17_-_56618178 2.994 NM_001198713
SEPT4
septin 4
chrX_+_66788682 2.986 NM_001011645
AR
androgen receptor
chr15_+_99645152 2.970 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr8_-_110620220 2.943 SYBU
syntabulin (syntaxin-interacting)
chr21_-_31538970 2.939 NM_012131
CLDN17
claudin 17
chr16_-_21289571 2.909 CRYM
crystallin, mu
chr11_+_61717355 2.856 NM_001139443
NM_004183
BEST1

bestrophin 1

chrX_+_114827818 2.830 NM_001136025
NM_001172335
PLS3

plastin 3

chr7_+_39017608 2.768 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr8_+_24298442 2.752 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr1_-_201915715 2.676 NM_012134
LMOD1
leiomodin 1 (smooth muscle)
chr4_-_155533757 2.674 FGG
fibrinogen gamma chain
chr3_+_45067750 2.617 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chrX_-_11284094 2.576 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr12_-_91398744 2.446 EPYC
epiphycan
chr11_+_92085261 2.439 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr3_+_46616044 2.415 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr1_+_54359859 2.383 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr10_-_13749622 2.382 FRMD4A
FERM domain containing 4A
chr3_+_8543539 2.269 LMCD1
LIM and cysteine-rich domains 1
chr19_+_46171501 2.254 NM_000164
GIPR
gastric inhibitory polypeptide receptor
chr13_-_46679143 2.229 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr19_+_50016500 2.222 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr16_+_82068958 2.208 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr22_-_25777543 2.206 NM_001135772
LRP5L
low density lipoprotein receptor-related protein 5-like
chr1_+_207277577 2.195 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr14_-_24584125 2.189 NRL
neural retina leucine zipper
chr3_+_69915374 2.173 NM_198177
MITF
microphthalmia-associated transcription factor
chr4_-_159092509 2.155 FAM198B
family with sequence similarity 198, member B
chr1_-_203154304 2.135 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr5_+_140718353 2.132 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr2_-_77749335 2.101 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr11_-_55703875 2.095 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chrX_+_99839789 2.080 NM_022144
TNMD
tenomodulin
chr17_+_68071386 2.054 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr2_-_209028288 2.009 NM_014617
CRYGA
crystallin, gamma A
chr3_-_148939784 1.978 NM_000096
CP
ceruloplasmin (ferroxidase)
chr5_-_138210992 1.911 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr4_+_106473776 1.897 NM_001242729
NM_017700
ARHGEF38

Rho guanine nucleotide exchange factor (GEF) 38

chr16_+_82068910 1.843 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr5_+_140749830 1.834 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr6_-_32977351 1.825 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr6_+_71136141 1.822 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr8_-_22089850 1.814 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr7_-_27159213 1.810 NM_030661
HOXA3
homeobox A3
chr8_-_27115935 1.808 STMN4
stathmin-like 4
chr12_-_93323006 1.797 EEA1
early endosome antigen 1
chr4_+_86699846 1.795 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr1_+_104292278 1.787 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr1_-_19217384 1.749 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr6_-_46047978 1.704 NM_001114086
CLIC5
chloride intracellular channel 5
chr4_+_113970784 1.690 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr11_+_131240370 1.657 NM_001048209
NTM
neurotrimin
chr3_-_120401401 1.629 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr1_+_36772696 1.623 NM_024676
SH3D21
SH3 domain containing 21
chr3_+_149192367 1.601 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr12_-_71551564 1.573 TSPAN8
tetraspanin 8
chr5_+_140734767 1.571 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr6_-_56507585 1.519 NM_001723
NM_015548
DST

dystonin

chr5_+_59784004 1.508 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr10_-_62332666 1.494 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_73109342 1.476 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr12_-_9360960 1.440 NM_002864
PZP
pregnancy-zone protein
chr12_-_113574020 1.439 NM_001193520
NM_004658
RASAL1

RAS protein activator like 1 (GAP1 like)

chr13_-_95131718 1.439 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr10_-_123353771 1.435 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr4_+_110749149 1.374 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr5_+_140809957 1.374 PCDHGA12
protocadherin gamma subfamily A, 12
chr4_-_70725792 1.336 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr4_+_154178525 1.331 TRIM2
tripartite motif containing 2
chr8_+_21916858 1.302 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chrX_-_62974987 1.279 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr12_-_91398757 1.258 NM_004950
EPYC
epiphycan
chr16_-_73092533 1.254 NM_001164766
ZFHX3
zinc finger homeobox 3
chr3_+_155838336 1.247 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr17_+_37856253 1.233 NM_004448
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr2_+_169937616 1.228 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_182419255 1.226 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr1_-_241799101 1.198 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr2_-_211018294 1.187 C2orf67
chromosome 2 open reading frame 67
chr17_+_27370155 1.174 PIPOX
pipecolic acid oxidase
chr2_-_69098502 1.173 NM_014482
BMP10
bone morphogenetic protein 10
chr7_+_27282163 1.171 NM_001989
EVX1
even-skipped homeobox 1
chr5_-_138211054 1.164 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr2_-_162929928 1.156 DPP4
dipeptidyl-peptidase 4
chr17_+_33448597 1.148 NM_017559
FNDC8
fibronectin type III domain containing 8
chr10_-_62149487 1.134 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr15_+_91769329 1.117 SV2B
synaptic vesicle glycoprotein 2B
chr6_+_50786438 1.109 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr17_+_4854383 1.085 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr8_+_80523351 1.043 STMN2
stathmin-like 2
chr2_-_165424993 1.038 GRB14
growth factor receptor-bound protein 14
chr14_-_94759360 1.029 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_-_99833348 1.026 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr12_-_21487831 0.984 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr10_+_98740987 0.947 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr3_-_114790221 0.942 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_31107110 0.927 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr11_-_13517525 0.923 NM_000315
PTH
parathyroid hormone
chrX_-_62975005 0.916 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr13_-_70682458 0.908 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr6_-_55740387 0.882 BMP5
bone morphogenetic protein 5
chr6_-_49754899 0.876 NM_138733
PGK2
phosphoglycerate kinase 2
chr21_+_43619798 0.844 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chrX_+_144908927 0.838 NM_004709
CXorf1
chromosome X open reading frame 1
chr6_+_101846668 0.833 GRIK2
glutamate receptor, ionotropic, kainate 2
chr3_-_52294427 0.824 WDR82
WD repeat domain 82
chr4_-_89744154 0.819 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr4_-_66536182 0.806 EPHA5
EPH receptor A5
chr11_-_85469043 0.798 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr20_-_49253425 0.791 NM_080829
FAM65C
family with sequence similarity 65, member C
chr12_-_13248581 0.769 NM_001206843
NM_001206845
NM_031289
NM_153823
GSG1



germ cell associated 1



chr10_+_94833646 0.768 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr2_+_176987412 0.738 NM_014213
HOXD9
homeobox D9
chr9_+_111624545 0.731 NM_006687
ACTL7A
actin-like 7A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.14 2.49e-04 GO:0048583 regulation of response to stimulus
1.54 8.12e-04 GO:0032501 multicellular organismal process
1.77 1.05e-03 GO:0048856 anatomical structure development
6.74 2.57e-03 GO:0007565 female pregnancy
1.64 3.05e-03 GO:0032502 developmental process
2.69 8.05e-03 GO:0007155 cell adhesion
2.69 8.05e-03 GO:0022610 biological adhesion
2.69 1.84e-02 GO:0030182 neuron differentiation
1.71 2.14e-02 GO:0048731 system development
2.05 2.46e-02 GO:0007399 nervous system development
3.69 3.27e-02 GO:0016337 cell-cell adhesion
2.83 3.28e-02 GO:0048666 neuron development
1.59 4.56e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.66 2.33e-05 GO:0044421 extracellular region part
2.04 5.71e-05 GO:0005576 extracellular region
1.98 8.29e-05 GO:0044459 plasma membrane part
2.76 2.30e-04 GO:0005615 extracellular space
1.58 5.87e-04 GO:0071944 cell periphery
2.61 7.12e-04 GO:0005626 insoluble fraction
1.57 1.24e-03 GO:0005886 plasma membrane
2.50 3.38e-03 GO:0005624 membrane fraction
2.25 2.72e-02 GO:0042995 cell projection
2.06 3.64e-02 GO:0000267 cell fraction

Nothing significant found in function category.