Motif ID: MYFfamily.p2

Z-value: 3.348


Transcription factors associated with MYFfamily.p2:

Gene SymbolEntrez IDGene Name
MYF5 4617 myogenic factor 5
MYF6 4618 myogenic factor 6 (herculin)
MYOD1 4654 myogenic differentiation 1
MYOG 4656 myogenin (myogenic factor 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MYF5chr12_+_811106890.665.3e-29Click!
MYOD1chr11_+_177411090.622.9e-24Click!
MYF6chr12_+_811014070.586.4e-21Click!
MYOGchr1_-_2030553760.472.0e-13Click!


Activity profile for motif MYFfamily.p2.

activity profile for motif MYFfamily.p2


Sorted Z-values histogram for motif MYFfamily.p2

Sorted Z-values for motif MYFfamily.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYFfamily.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137801178 63.601 NM_001964
EGR1
early growth response 1
chr1_-_57045214 50.183 PPAP2B
phosphatidic acid phosphatase type 2B
chr4_-_57976516 49.111 IGFBP7
insulin-like growth factor binding protein 7
chr4_-_57976550 49.068 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr6_+_99282597 47.833 POU3F2
POU class 3 homeobox 2
chr19_+_33182689 45.349 NM_001105570
NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr18_+_21594349 44.292 NM_001135993
NM_001243425
TTC39C

tetratricopeptide repeat domain 39C

chr4_-_57976355 42.453 IGFBP7
insulin-like growth factor binding protein 7
chr6_+_45390284 40.162 RUNX2
runt-related transcription factor 2
chr1_-_57045129 39.031 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57044980 38.705 PPAP2B
phosphatidic acid phosphatase type 2B
chr6_+_45390376 38.476 RUNX2
runt-related transcription factor 2
chr6_-_91006460 37.314 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_-_57045235 37.299 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_66218879 35.956 HMGA2
high mobility group AT-hook 2
chr3_-_195306274 34.921 APOD
apolipoprotein D
chr5_+_137801166 34.102 EGR1
early growth response 1
chr5_-_139422725 33.356 NRG2
neuregulin 2
chr2_+_203499819 32.973 NM_173511
FAM117B
family with sequence similarity 117, member B
chr5_-_178772328 30.762 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr11_+_57365577 29.884 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr5_+_113698304 29.142 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr16_+_90168671 28.823 FAM157C
family with sequence similarity 157, member C
chr22_+_22712091 27.965 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_-_67390413 27.913 NM_024763
NM_207014
WDR78

WD repeat domain 78

chr20_-_23066828 27.413 NM_012072
CD93
CD93 molecule
chr5_-_139422805 26.860 NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
NRG2




neuregulin 2




chr6_+_107811272 26.811 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr10_+_124220990 26.458 NM_002775
HTRA1
HtrA serine peptidase 1
chr5_-_178772430 26.453 NM_014244
NM_021599
ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

chrX_+_21392396 26.084 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr10_+_74451838 25.704 NM_138357
MCU
mitochondrial calcium uniporter
chr14_-_60337350 24.849 NM_021136
RTN1
reticulon 1
chr3_+_111717585 24.789 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr2_+_105471745 24.570 NM_006236
POU3F3
POU class 3 homeobox 3
chr11_-_117747331 23.139 FXYD6
FXYD domain containing ion transport regulator 6
chr2_+_191745568 22.566 GLS
glutaminase
chr17_-_15902907 22.375 NM_001042697
NM_001042698
ZSWIM7

zinc finger, SWIM-type containing 7

chrX_-_107979606 22.266 NM_003604
IRS4
insulin receptor substrate 4
chrX_-_54209639 21.910 NM_017848
NM_198456
FAM120C

family with sequence similarity 120C

chr6_-_91006580 21.889 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_+_54519259 21.811 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr15_-_93198602 21.786 NM_207446
FAM174B
family with sequence similarity 174, member B
chr7_-_137531585 21.478 NM_004717
DGKI
diacylglycerol kinase, iota
chr5_+_113698015 21.245 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr8_+_37654757 21.237 GPR124
G protein-coupled receptor 124
chr22_+_33197678 21.137 TIMP3
TIMP metallopeptidase inhibitor 3
chr1_-_59042827 21.131 TACSTD2
tumor-associated calcium signal transducer 2
chr5_-_147162175 20.917 JAKMIP2
janus kinase and microtubule interacting protein 2
chr6_-_32191779 20.652 NM_004557
NOTCH4
notch 4
chr3_-_169381417 20.441 NM_001205194
NM_004991
MECOM

MDS1 and EVI1 complex locus

chr19_+_32836500 20.347 NM_001136156
NM_014910
ZNF507

zinc finger protein 507

chrX_-_92928566 20.152 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr10_-_48438975 19.558 NM_004962
GDF10
growth differentiation factor 10
chr2_-_172967627 19.555 DLX2
distal-less homeobox 2
chr9_+_35560424 19.192 RUSC2
RUN and SH3 domain containing 2
chr1_+_11866240 19.179 CLCN6
chloride channel 6
chr10_+_120967094 18.983 NM_005308
GRK5
G protein-coupled receptor kinase 5
chr17_+_14204326 18.927 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr2_-_47797469 18.334 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr3_-_4508939 18.282 SUMF1
sulfatase modifying factor 1
chr3_+_49449753 18.180 TCTA
T-cell leukemia translocation altered gene
chr3_-_120068077 18.164 NM_001099678
LRRC58
leucine rich repeat containing 58
chr19_-_18314731 17.986 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr5_+_140864626 17.981 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr6_+_42897184 17.687 CNPY3
canopy 3 homolog (zebrafish)
chr10_-_90967048 17.600 NM_003956
CH25H
cholesterol 25-hydroxylase
chr2_-_172967234 17.366 NM_004405
DLX2
distal-less homeobox 2
chr12_+_4918341 17.208 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr5_-_147162251 16.979 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr9_+_127539382 16.903 NM_182487
OLFML2A
olfactomedin-like 2A
chr13_-_36050758 16.786 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr1_+_153651050 16.712 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr6_+_41040713 16.626 NFYA
nuclear transcription factor Y, alpha
chr12_+_120427476 16.564 NM_207311
CCDC64
coiled-coil domain containing 64
chr8_-_133492751 16.441 KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr5_-_95297424 16.175 ELL2
elongation factor, RNA polymerase II, 2
chr7_+_153749740 16.000 NM_130797
DPP6
dipeptidyl-peptidase 6
chr8_+_24771276 15.982 NEFM
neurofilament, medium polypeptide
chr15_+_96873845 15.908 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr3_+_49449638 15.701 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr10_+_72163860 15.689 NM_004096
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr11_-_117747618 15.526 NM_001204268
NM_001243598
NM_001164832
NM_001164836
NM_001164837
NM_022003
FXYD6-FXYD2

FXYD6



FXYD6-FXYD2 readthrough

FXYD domain containing ion transport regulator 6



chr1_+_171810611 15.458 NM_001136127
NM_015569
DNM3

dynamin 3

chr2_+_176957448 15.239 NM_000523
HOXD13
homeobox D13
chr1_-_11865963 14.851 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chrX_-_110513750 14.593 NM_014289
CAPN6
calpain 6
chr9_+_133320093 14.552 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr4_-_39640461 14.512 NM_174921
C4orf34
chromosome 4 open reading frame 34
chr9_+_133320247 14.448 ASS1
argininosuccinate synthase 1
chr1_+_25071906 14.362 CLIC4
chloride intracellular channel 4
chr11_-_66335958 14.283 NM_003793
CTSF
cathepsin F
chr17_+_38599651 14.152 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr8_+_37654395 14.135 NM_032777
GPR124
G protein-coupled receptor 124
chr3_-_129612371 14.114 NM_001128224
TMCC1
transmembrane and coiled-coil domain family 1
chr2_-_48982809 14.096 NM_000233
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr2_-_160654668 14.004 CD302
CD302 molecule
chr13_+_113951461 13.897 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr9_+_130548358 13.742 CDK9
cyclin-dependent kinase 9
chr6_+_41040687 13.624 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chr8_+_37654833 13.608 GPR124
G protein-coupled receptor 124
chr19_+_41103055 13.546 NM_001042544
LTBP4
latent transforming growth factor beta binding protein 4
chr5_-_146258143 13.270 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr12_-_56101667 13.246 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr14_-_27066959 13.169 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr8_+_85095452 13.142 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr10_+_104678001 13.063 NM_017649
NM_199076
NM_199077
CNNM2


cyclin M2


chr2_-_160654736 13.060 NM_001198763
NM_001198764
NM_014880
CD302


CD302 molecule


chr10_-_73848263 13.030 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr1_+_11866206 13.017 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr9_-_84304378 12.982 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr14_-_75078669 12.959 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr8_+_37654406 12.947 GPR124
G protein-coupled receptor 124
chr7_-_137028275 12.909 PTN
pleiotrophin
chr2_+_26915390 12.830 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr5_+_140346053 12.830 PCDHAC2
protocadherin alpha subfamily C, 2
chr17_+_40913211 12.821 NM_005854
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr4_+_71570768 12.766 RUFY3
RUN and FYVE domain containing 3
chr19_+_3094266 12.726 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chrX_-_107018889 12.717 TSC22D3
TSC22 domain family, member 3
chr16_-_74641014 12.668 NM_001145666
NM_001145667
NM_012201
GLG1


golgi glycoprotein 1


chr9_-_120177326 12.604 ASTN2
astrotactin 2
chr15_-_53082087 12.598 NM_004498
ONECUT1
one cut homeobox 1
chr6_+_129204285 12.597 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chrX_+_69282340 12.560 NM_207320
OTUD6A
OTU domain containing 6A
chr22_+_23229959 12.530 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr14_+_59104736 12.520 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr17_-_39743085 12.519 NM_000526
KRT14
keratin 14
chr17_-_42200957 12.461 HDAC5
histone deacetylase 5
chr8_+_24771268 12.444 NM_005382
NEFM
neurofilament, medium polypeptide
chr22_+_22676814 12.431


chr8_-_33457491 12.352 DUSP26
dual specificity phosphatase 26 (putative)
chr14_+_29236882 12.283 FOXG1
forkhead box G1
chr9_+_87284625 12.270 NM_001007097
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr12_+_53440809 12.260 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr11_+_113930296 12.256 ZBTB16
zinc finger and BTB domain containing 16
chr2_+_79740059 12.237 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr1_+_209848659 12.183 NM_015714
G0S2
G0/G1switch 2
chr9_+_27109138 12.173 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr22_+_45898690 12.171 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr20_-_45280059 12.131 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr19_+_13875345 12.120 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr19_-_47734215 12.038 NM_014417
BBC3
BCL2 binding component 3
chr2_+_48541767 11.968 NM_002158
FOXN2
forkhead box N2
chr6_+_7727010 11.947 NM_001718
BMP6
bone morphogenetic protein 6
chr1_-_54518790 11.941 TMEM59
transmembrane protein 59
chr20_-_44563684 11.897 FLJ40606
uncharacterized LOC643549
chr21_+_47545896 11.891 COL6A2
collagen, type VI, alpha 2
chr6_-_111136616 11.857 CDK19
cyclin-dependent kinase 19
chr14_-_52535737 11.826 NID2
nidogen 2 (osteonidogen)
chr15_+_99645152 11.819 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr5_+_137774897 11.723 REEP2
receptor accessory protein 2
chr13_-_95364248 11.659 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr7_+_72848108 11.619 NM_003508
FZD9
frizzled family receptor 9
chr10_-_95360959 11.616 NM_006744
RBP4
retinol binding protein 4, plasma
chr19_+_51628136 11.566 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr1_+_47603083 11.539 NM_001010969
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr4_+_71570616 11.458 NM_001130709
RUFY3
RUN and FYVE domain containing 3
chr7_+_158649200 11.438 NM_018051
WDR60
WD repeat domain 60
chr9_+_130548304 11.390 NM_001261
CDK9
cyclin-dependent kinase 9
chr1_+_25071967 11.383 CLIC4
chloride intracellular channel 4
chr11_-_9113092 11.369 NM_001170690
NM_020974
SCUBE2

signal peptide, CUB domain, EGF-like 2

chr2_+_191745791 11.338 GLS
glutaminase
chr3_-_187463474 11.313 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr8_-_133492556 11.272 KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr11_+_65837785 11.262 NM_018026
PACS1
phosphofurin acidic cluster sorting protein 1
chr1_-_58716207 11.255 NM_021080
DAB1
disabled homolog 1 (Drosophila)
chr8_-_33457435 11.206 NM_024025
DUSP26
dual specificity phosphatase 26 (putative)
chr10_+_12391728 11.168 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr13_-_114567011 11.157 GAS6
growth arrest-specific 6
chr3_-_73673978 11.126 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr15_+_92937104 11.108 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr16_-_74640915 11.097 GLG1
golgi glycoprotein 1
chr11_-_12030128 11.048 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr22_+_33197744 11.044 TIMP3
TIMP metallopeptidase inhibitor 3
chr12_-_56101465 10.988 ITGA7
integrin, alpha 7
chr6_+_64345672 10.985 PHF3
PHD finger protein 3
chrX_-_140271275 10.952 LDOC1
leucine zipper, down-regulated in cancer 1
chr1_-_200379072 10.948 ZNF281
zinc finger protein 281
chr8_-_27472188 10.935 CLU
clusterin
chr1_+_202317798 10.917 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr2_+_206547352 10.916 NRP2
neuropilin 2
chr16_-_11836602 10.889 NM_015914
TXNDC11
thioredoxin domain containing 11
chrX_-_106960028 10.888 TSC22D3
TSC22 domain family, member 3
chr20_-_23618382 10.883 NM_000099
CST3
cystatin C
chr22_+_21986968 10.880 NM_152612
CCDC116
coiled-coil domain containing 116
chr16_-_68014362 10.867 NM_001129758
NM_022357
DPEP3

dipeptidase 3

chrX_+_110187468 10.800 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chr1_-_11866079 10.792 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr6_+_37137882 10.780 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr22_-_18923654 10.760 PRODH
proline dehydrogenase (oxidase) 1
chr19_+_13875299 10.728 NM_001031727
NM_032285
MRI1

methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)

chr1_+_233749749 10.677 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr3_+_111718006 10.621 NM_001008273
TAGLN3
transgelin 3
chr2_+_20646831 10.578 NM_004040
RHOB
ras homolog gene family, member B
chr1_-_38512446 10.510 NM_002699
POU3F1
POU class 3 homeobox 1
chr9_+_124030455 10.499 GSN
gelsolin
chr1_-_32229635 10.485 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr7_+_39990108 10.479 CDK13
cyclin-dependent kinase 13
chr1_-_59248287 10.443 JUN
jun proto-oncogene

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 2.72e-38 GO:0023052 signaling
1.47 2.13e-36 GO:0032502 developmental process
1.52 1.18e-34 GO:0048856 anatomical structure development
1.36 3.34e-34 GO:0032501 multicellular organismal process
1.48 2.92e-33 GO:0007275 multicellular organismal development
1.54 3.77e-33 GO:0048731 system development
1.25 1.05e-31 GO:0065007 biological regulation
1.45 1.21e-28 GO:0007165 signal transduction
1.24 2.76e-25 GO:0050789 regulation of biological process
1.60 2.02e-24 GO:0048513 organ development
1.59 2.46e-22 GO:0007166 cell surface receptor linked signaling pathway
1.35 2.46e-22 GO:0051716 cellular response to stimulus
1.24 2.56e-22 GO:0050794 regulation of cellular process
1.14 5.84e-22 GO:0009987 cellular process
1.64 5.04e-21 GO:0007399 nervous system development
1.50 1.03e-20 GO:0042221 response to chemical stimulus
1.25 4.36e-20 GO:0050896 response to stimulus
1.60 1.98e-18 GO:0009653 anatomical structure morphogenesis
1.49 5.70e-18 GO:0048869 cellular developmental process
1.49 8.70e-18 GO:0030154 cell differentiation
1.46 3.56e-16 GO:0065008 regulation of biological quality
1.82 6.22e-16 GO:0007267 cell-cell signaling
1.81 9.72e-16 GO:0007155 cell adhesion
1.81 9.72e-16 GO:0022610 biological adhesion
1.60 2.17e-15 GO:0051239 regulation of multicellular organismal process
1.70 3.41e-14 GO:0050793 regulation of developmental process
1.68 1.45e-13 GO:0022008 neurogenesis
1.68 2.10e-13 GO:0048468 cell development
1.70 2.40e-13 GO:0048699 generation of neurons
1.77 1.64e-12 GO:0030182 neuron differentiation
1.62 2.60e-12 GO:0007154 cell communication
1.55 4.65e-12 GO:0002376 immune system process
1.95 5.09e-12 GO:0051094 positive regulation of developmental process
1.62 8.60e-12 GO:0032879 regulation of localization
1.66 1.14e-11 GO:0040011 locomotion
1.75 1.25e-11 GO:0045595 regulation of cell differentiation
1.89 1.53e-11 GO:0019226 transmission of nerve impulse
1.89 1.53e-11 GO:0035637 multicellular organismal signaling
1.63 2.58e-11 GO:0009611 response to wounding
1.79 2.70e-11 GO:0009887 organ morphogenesis
1.86 3.72e-11 GO:0007417 central nervous system development
1.33 5.44e-11 GO:0048518 positive regulation of biological process
1.41 6.28e-11 GO:0048583 regulation of response to stimulus
1.69 7.28e-11 GO:2000026 regulation of multicellular organismal development
1.79 1.10e-10 GO:0048666 neuron development
2.05 1.39e-10 GO:0045597 positive regulation of cell differentiation
1.44 1.56e-10 GO:0023051 regulation of signaling
1.51 1.91e-10 GO:0010033 response to organic substance
1.58 3.61e-10 GO:0042127 regulation of cell proliferation
2.22 8.86e-10 GO:0030168 platelet activation
1.87 1.79e-09 GO:0007268 synaptic transmission
1.80 2.60e-09 GO:0000904 cell morphogenesis involved in differentiation
1.69 5.31e-09 GO:0007167 enzyme linked receptor protein signaling pathway
1.71 7.17e-09 GO:0000902 cell morphogenesis
1.93 7.87e-09 GO:0007420 brain development
1.84 9.54e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.52 1.00e-08 GO:0010646 regulation of cell communication
1.77 2.12e-08 GO:0048858 cell projection morphogenesis
1.75 3.05e-08 GO:0006935 chemotaxis
1.75 3.05e-08 GO:0042330 taxis
1.57 3.18e-08 GO:0009888 tissue development
1.67 3.25e-08 GO:0030030 cell projection organization
1.81 3.52e-08 GO:0048812 neuron projection morphogenesis
1.76 3.84e-08 GO:0001775 cell activation
1.67 3.88e-08 GO:0032989 cellular component morphogenesis
1.75 4.21e-08 GO:0032990 cell part morphogenesis
1.74 1.04e-07 GO:0007599 hemostasis
1.31 1.15e-07 GO:0048522 positive regulation of cellular process
1.74 1.34e-07 GO:0007596 blood coagulation
1.74 1.34e-07 GO:0050817 coagulation
1.67 1.34e-07 GO:0042060 wound healing
1.24 1.99e-07 GO:0051179 localization
1.80 2.04e-07 GO:0007409 axonogenesis
1.73 2.38e-07 GO:0031175 neuron projection development
1.65 2.51e-07 GO:0009725 response to hormone stimulus
1.30 4.29e-07 GO:0048519 negative regulation of biological process
1.73 5.81e-07 GO:0072358 cardiovascular system development
1.73 5.81e-07 GO:0072359 circulatory system development
1.60 7.20e-07 GO:0009719 response to endogenous stimulus
1.51 7.54e-07 GO:0006811 ion transport
1.92 8.20e-07 GO:0019932 second-messenger-mediated signaling
1.56 1.08e-06 GO:0006955 immune response
1.88 1.25e-06 GO:0001501 skeletal system development
1.90 1.53e-06 GO:0016337 cell-cell adhesion
1.39 1.85e-06 GO:0009966 regulation of signal transduction
1.64 1.86e-06 GO:0050878 regulation of body fluid levels
1.53 1.96e-06 GO:0048584 positive regulation of response to stimulus
1.47 2.51e-06 GO:0009605 response to external stimulus
1.91 2.67e-06 GO:0051270 regulation of cellular component movement
2.26 3.68e-06 GO:0019935 cyclic-nucleotide-mediated signaling
1.30 4.02e-06 GO:0048523 negative regulation of cellular process
1.90 4.45e-06 GO:0007423 sensory organ development
1.86 5.11e-06 GO:0022603 regulation of anatomical structure morphogenesis
1.55 6.08e-06 GO:0051049 regulation of transport
1.39 6.54e-06 GO:0035556 intracellular signal transduction
1.83 7.59e-06 GO:0051093 negative regulation of developmental process
2.13 1.29e-05 GO:0030900 forebrain development
2.08 1.31e-05 GO:0048732 gland development
1.63 1.87e-05 GO:0008284 positive regulation of cell proliferation
1.82 2.07e-05 GO:0007610 behavior
1.79 2.73e-05 GO:0007411 axon guidance
1.80 2.80e-05 GO:0060284 regulation of cell development
1.85 2.82e-05 GO:0040012 regulation of locomotion
2.76 4.38e-05 GO:0050770 regulation of axonogenesis
1.84 6.00e-05 GO:0051960 regulation of nervous system development
1.26 6.92e-05 GO:0006950 response to stress
1.89 7.26e-05 GO:0050767 regulation of neurogenesis
1.54 7.36e-05 GO:0001932 regulation of protein phosphorylation
2.12 9.84e-05 GO:0048562 embryonic organ morphogenesis
1.98 1.10e-04 GO:0045664 regulation of neuron differentiation
1.66 1.42e-04 GO:0016477 cell migration
1.85 1.44e-04 GO:0030334 regulation of cell migration
1.82 1.45e-04 GO:0048545 response to steroid hormone stimulus
2.65 1.56e-04 GO:0022612 gland morphogenesis
1.74 1.77e-04 GO:0044057 regulation of system process
1.51 1.91e-04 GO:0042325 regulation of phosphorylation
1.70 1.92e-04 GO:0048598 embryonic morphogenesis
1.58 2.27e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.83 2.54e-04 GO:0045596 negative regulation of cell differentiation
1.83 2.54e-04 GO:2000145 regulation of cell motility
1.51 2.70e-04 GO:0071310 cellular response to organic substance
1.49 2.81e-04 GO:0019220 regulation of phosphate metabolic process
1.49 2.81e-04 GO:0051174 regulation of phosphorus metabolic process
1.78 3.13e-04 GO:0001944 vasculature development
1.42 3.19e-04 GO:0070887 cellular response to chemical stimulus
2.32 3.32e-04 GO:0061138 morphogenesis of a branching epithelium
2.26 4.82e-04 GO:0019933 cAMP-mediated signaling
1.32 4.98e-04 GO:0065009 regulation of molecular function
1.61 5.26e-04 GO:0046903 secretion
1.95 6.13e-04 GO:0048608 reproductive structure development
1.77 6.57e-04 GO:0061061 muscle structure development
1.72 7.00e-04 GO:0051046 regulation of secretion
2.15 7.36e-04 GO:0048705 skeletal system morphogenesis
1.35 7.95e-04 GO:0050790 regulation of catalytic activity
1.61 8.67e-04 GO:0008285 negative regulation of cell proliferation
2.00 8.96e-04 GO:0006936 muscle contraction
2.15 9.46e-04 GO:0001763 morphogenesis of a branching structure
2.06 9.61e-04 GO:0045165 cell fate commitment
3.13 1.07e-03 GO:0009187 cyclic nucleotide metabolic process
1.53 1.14e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
2.43 1.20e-03 GO:0007160 cell-matrix adhesion
2.08 1.61e-03 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
1.59 1.70e-03 GO:0060341 regulation of cellular localization
2.19 1.95e-03 GO:0043583 ear development
1.50 1.97e-03 GO:0006812 cation transport
1.42 2.15e-03 GO:0051128 regulation of cellular component organization
1.66 2.20e-03 GO:0007389 pattern specification process
1.68 2.29e-03 GO:0051050 positive regulation of transport
1.20 2.33e-03 GO:0006810 transport
1.20 2.49e-03 GO:0051234 establishment of localization
2.29 2.77e-03 GO:0048839 inner ear development
1.97 3.04e-03 GO:0048511 rhythmic process
1.68 3.15e-03 GO:0032940 secretion by cell
1.53 3.23e-03 GO:0048585 negative regulation of response to stimulus
2.08 3.45e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
1.94 3.52e-03 GO:0001934 positive regulation of protein phosphorylation
3.25 3.68e-03 GO:0042733 embryonic digit morphogenesis
1.43 3.80e-03 GO:0006468 protein phosphorylation
2.24 3.95e-03 GO:0031589 cell-substrate adhesion
1.81 4.52e-03 GO:0048514 blood vessel morphogenesis
1.50 4.88e-03 GO:0006928 cellular component movement
1.97 5.07e-03 GO:0001666 response to hypoxia
1.72 5.20e-03 GO:0001568 blood vessel development
2.16 5.59e-03 GO:0048736 appendage development
2.16 5.59e-03 GO:0060173 limb development
2.03 5.59e-03 GO:0060191 regulation of lipase activity
1.87 5.69e-03 GO:0042327 positive regulation of phosphorylation
1.58 5.70e-03 GO:0009968 negative regulation of signal transduction
1.55 5.77e-03 GO:0008283 cell proliferation
1.76 5.86e-03 GO:0007507 heart development
1.55 6.15e-03 GO:0023057 negative regulation of signaling
1.85 6.18e-03 GO:0007517 muscle organ development
1.77 6.30e-03 GO:0048568 embryonic organ development
1.55 6.33e-03 GO:0002684 positive regulation of immune system process
1.90 6.63e-03 GO:0045137 development of primary sexual characteristics
1.55 6.96e-03 GO:0010648 negative regulation of cell communication
2.19 7.00e-03 GO:0031279 regulation of cyclase activity
2.03 7.22e-03 GO:0043627 response to estrogen stimulus
1.92 7.26e-03 GO:0070482 response to oxygen levels
2.05 7.32e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.87 7.32e-03 GO:0003012 muscle system process
2.02 9.15e-03 GO:0001503 ossification
2.04 9.32e-03 GO:0022604 regulation of cell morphogenesis
1.51 9.53e-03 GO:0030001 metal ion transport
2.09 9.55e-03 GO:0060541 respiratory system development
1.84 1.02e-02 GO:0010562 positive regulation of phosphorus metabolic process
1.84 1.02e-02 GO:0045937 positive regulation of phosphate metabolic process
1.62 1.04e-02 GO:0003006 developmental process involved in reproduction
2.17 1.19e-02 GO:0045761 regulation of adenylate cyclase activity
1.53 1.19e-02 GO:0048870 cell motility
1.53 1.19e-02 GO:0051674 localization of cell
2.04 1.20e-02 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.04 1.20e-02 GO:0030808 regulation of nucleotide biosynthetic process
2.15 1.21e-02 GO:0051339 regulation of lyase activity
3.29 1.23e-02 GO:0061035 regulation of cartilage development
2.10 1.23e-02 GO:0010517 regulation of phospholipase activity
1.25 1.84e-02 GO:0003008 system process
1.50 1.85e-02 GO:0043549 regulation of kinase activity
1.17 1.92e-02 GO:0080090 regulation of primary metabolic process
1.86 2.02e-02 GO:0030155 regulation of cell adhesion
2.13 2.04e-02 GO:0007202 activation of phospholipase C activity
2.08 2.05e-02 GO:0003001 generation of a signal involved in cell-cell signaling
2.08 2.05e-02 GO:0023061 signal release
1.41 2.08e-02 GO:0009790 embryo development
2.31 2.17e-02 GO:0002576 platelet degranulation
1.72 2.21e-02 GO:0003002 regionalization
3.18 2.22e-02 GO:0045778 positive regulation of ossification
1.96 2.28e-02 GO:0007156 homophilic cell adhesion
1.79 2.42e-02 GO:0010817 regulation of hormone levels
1.90 2.49e-02 GO:0008406 gonad development
2.37 2.53e-02 GO:0006937 regulation of muscle contraction
2.13 2.62e-02 GO:0048754 branching morphogenesis of a tube
2.11 2.64e-02 GO:0010863 positive regulation of phospholipase C activity
1.94 2.83e-02 GO:0016055 Wnt receptor signaling pathway
1.37 2.87e-02 GO:0044093 positive regulation of molecular function
2.38 3.20e-02 GO:0042472 inner ear morphogenesis
1.90 3.21e-02 GO:0034330 cell junction organization
2.00 3.23e-02 GO:0002791 regulation of peptide secretion
2.00 3.23e-02 GO:0090087 regulation of peptide transport
2.02 3.30e-02 GO:0030814 regulation of cAMP metabolic process
2.11 3.41e-02 GO:0030323 respiratory tube development
1.40 3.59e-02 GO:0002682 regulation of immune system process
1.47 3.63e-02 GO:0051338 regulation of transferase activity
2.71 3.67e-02 GO:0048663 neuron fate commitment
2.25 3.97e-02 GO:0042471 ear morphogenesis
1.76 4.09e-02 GO:0007548 sex differentiation
1.55 4.10e-02 GO:0060429 epithelium development
2.14 4.35e-02 GO:0030326 embryonic limb morphogenesis
2.14 4.35e-02 GO:0035113 embryonic appendage morphogenesis
2.07 4.39e-02 GO:0035107 appendage morphogenesis
2.07 4.39e-02 GO:0035108 limb morphogenesis
1.55 4.50e-02 GO:0045087 innate immune response
1.33 4.68e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.63 4.81e-02 GO:0035295 tube development
1.15 4.82e-02 GO:0019222 regulation of metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.64 1.21e-35 GO:0044459 plasma membrane part
1.77 1.08e-27 GO:0031226 intrinsic to plasma membrane
1.77 5.94e-27 GO:0005887 integral to plasma membrane
1.36 6.46e-26 GO:0005886 plasma membrane
1.36 1.39e-25 GO:0071944 cell periphery
1.73 8.01e-20 GO:0044421 extracellular region part
1.47 1.40e-17 GO:0005576 extracellular region
2.08 1.88e-14 GO:0031012 extracellular matrix
1.70 2.11e-13 GO:0005615 extracellular space
1.64 5.90e-12 GO:0005626 insoluble fraction
1.53 3.94e-11 GO:0000267 cell fraction
1.62 6.61e-11 GO:0005624 membrane fraction
1.14 1.06e-09 GO:0016020 membrane
1.97 1.35e-09 GO:0005578 proteinaceous extracellular matrix
1.15 2.30e-07 GO:0044425 membrane part
1.56 5.17e-06 GO:0030054 cell junction
2.32 8.98e-06 GO:0044420 extracellular matrix part
1.64 3.05e-05 GO:0045202 synapse
1.86 1.07e-04 GO:0034702 ion channel complex
1.42 1.75e-04 GO:0031982 vesicle
1.13 4.12e-04 GO:0031224 intrinsic to membrane
1.60 4.20e-04 GO:0009986 cell surface
2.75 4.35e-04 GO:0031983 vesicle lumen
1.41 4.92e-04 GO:0031410 cytoplasmic vesicle
1.68 5.20e-04 GO:0044456 synapse part
1.41 7.92e-04 GO:0031988 membrane-bounded vesicle
2.00 9.01e-04 GO:0043235 receptor complex
2.79 9.26e-04 GO:0031093 platelet alpha granule lumen
2.73 1.44e-03 GO:0034774 secretory granule lumen
2.38 1.88e-03 GO:0005604 basement membrane
1.39 2.38e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
2.98 2.51e-03 GO:0005581 collagen
1.76 3.02e-03 GO:0030141 stored secretory granule
2.62 3.30e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.12 7.60e-03 GO:0016021 integral to membrane
1.33 9.08e-03 GO:0042995 cell projection
2.41 1.16e-02 GO:0031091 platelet alpha granule
1.77 3.64e-02 GO:0045211 postsynaptic membrane
1.81 3.74e-02 GO:0034703 cation channel complex
2.79 4.09e-02 GO:0042611 MHC protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 4.72e-12 GO:0005515 protein binding
1.09 1.35e-10 GO:0005488 binding
1.54 2.26e-10 GO:0005102 receptor binding
1.68 3.34e-10 GO:0005509 calcium ion binding
2.67 1.15e-08 GO:0019838 growth factor binding
2.80 3.21e-07 GO:0019199 transmembrane receptor protein kinase activity
1.30 1.13e-06 GO:0004871 signal transducer activity
1.30 1.13e-06 GO:0060089 molecular transducer activity
1.90 1.84e-06 GO:0032403 protein complex binding
1.82 2.39e-06 GO:0022836 gated channel activity
1.71 5.31e-06 GO:0005216 ion channel activity
1.69 6.70e-06 GO:0022838 substrate-specific channel activity
1.52 9.56e-06 GO:0043565 sequence-specific DNA binding
2.84 1.53e-05 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.66 2.08e-05 GO:0015267 channel activity
1.65 2.41e-05 GO:0022803 passive transmembrane transporter activity
1.48 2.77e-05 GO:0015075 ion transmembrane transporter activity
1.78 8.78e-05 GO:0005261 cation channel activity
1.46 9.64e-05 GO:0042802 identical protein binding
1.38 1.54e-04 GO:0022892 substrate-specific transporter activity
1.41 1.78e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.39 2.64e-04 GO:0022857 transmembrane transporter activity
1.48 4.90e-04 GO:0004672 protein kinase activity
4.47 5.13e-04 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
1.48 1.26e-03 GO:0008324 cation transmembrane transporter activity
1.32 1.33e-03 GO:0005215 transporter activity
3.41 1.70e-03 GO:0005158 insulin receptor binding
2.31 2.57e-03 GO:0005201 extracellular matrix structural constituent
1.97 2.85e-03 GO:0004713 protein tyrosine kinase activity
1.57 2.89e-03 GO:0030246 carbohydrate binding
3.48 5.59e-03 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
1.39 5.67e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.25 5.77e-03 GO:0004872 receptor activity
1.74 8.51e-03 GO:0000975 regulatory region DNA binding
1.74 8.51e-03 GO:0001067 regulatory region nucleic acid binding
1.74 8.51e-03 GO:0044212 transcription regulatory region DNA binding
1.37 8.85e-03 GO:0016301 kinase activity
1.32 9.83e-03 GO:0001071 nucleic acid binding transcription factor activity
1.32 9.83e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.75 9.90e-03 GO:0010843 promoter binding
3.34 1.07e-02 GO:0004112 cyclic-nucleotide phosphodiesterase activity
1.87 1.19e-02 GO:0005539 glycosaminoglycan binding
2.33 2.02e-02 GO:0005178 integrin binding
1.80 2.25e-02 GO:0001871 pattern binding
1.80 2.25e-02 GO:0030247 polysaccharide binding
2.03 2.41e-02 GO:0005057 receptor signaling protein activity
5.22 2.82e-02 GO:0043121 neurotrophin binding
1.39 3.74e-02 GO:0005198 structural molecule activity
1.90 4.08e-02 GO:0030674 protein binding, bridging
1.30 4.18e-02 GO:0030234 enzyme regulator activity
1.93 4.47e-02 GO:0008201 heparin binding
1.45 4.48e-02 GO:0042803 protein homodimerization activity
1.48 4.59e-02 GO:0008047 enzyme activator activity
1.76 4.92e-02 GO:0008083 growth factor activity