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• Activity deltas table
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Motif ID: NFE2.p2

Z-value: 1.304

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_223889253	58.343	NM_001146068	CAPN2	calpain 2, (m/II) large subunit
chr14_+_58711599	34.969		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_30771520	33.274		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_31704070	19.958		CLIC1	chloride intracellular channel 1
chr3_+_183894736	19.601		AP2M1	adaptor-related protein complex 2, mu 1 subunit
chr6_-_31704318	17.903	NM_001288	CLIC1	chloride intracellular channel 1
chr6_-_31704304	17.433		CLIC1	chloride intracellular channel 1
chr11_-_65667858	17.413		FOSL1	FOS-like antigen 1
chr6_-_31704093	17.275		CLIC1	chloride intracellular channel 1
chr14_+_58711555	17.235		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr6_-_31704281	17.134		CLIC1	chloride intracellular channel 1
chr6_-_31704272	17.042		CLIC1	chloride intracellular channel 1
chr14_+_58711457	17.026	NM_002788 NM_152132	PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr6_-_31704287	16.977		CLIC1	chloride intracellular channel 1
chr17_+_30771494	16.694	NM_002815	PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_-_65667809	16.689		FOSL1	FOS-like antigen 1
chr17_+_30771522	16.580		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485	16.476		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_40735749	16.173		ZMPSTE24	zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr11_-_16996559	15.917		RPL36A	ribosomal protein L36a
chr11_-_65667860	15.708	NM_005438	FOSL1	FOS-like antigen 1
chr17_+_30771532	15.007		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_-_14541867	14.926		PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chr1_-_109969058	14.298	NM_001199772 NM_002790 NM_001199773 NM_001199774	PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr11_-_14541886	14.095	NM_001143937 NM_002786	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chr16_-_69760444	13.935	NM_000903 NM_001025433 NM_001025434	NQO1	NAD(P)H dehydrogenase, quinone 1
chr2_+_162164785	13.717	NM_005805	PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr17_-_73150769	13.643	NM_001002032 NM_001002033 NM_016185	HN1	hematological and neurological expressed 1
chrX_-_15511710	13.088	NM_001018109 NM_003662	PIR	pirin (iron-binding nuclear protein)
chr5_+_72143993	13.042		TNPO1	transportin 1
chr1_-_109969044	12.951		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr3_+_50284325	12.913	NM_001166425	GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_-_225616556	12.896	NM_194442	LBR	lamin B receptor
chr1_-_45987548	12.592	NM_002574 NM_181696 NM_181697	PRDX1	peroxiredoxin 1
chr11_+_35160385	12.251	NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 NM_001202555 NM_001202556 NM_001202557	CD44	CD44 molecule (Indian blood group)
chr10_+_17270257	12.248	NM_003380	VIM	vimentin
chr3_-_98241357	12.040		CLDND1	claudin domain containing 1
chr1_+_223900061	11.877	NM_001748	CAPN2	calpain 2, (m/II) large subunit
chrX_-_153285334	11.649	NM_001025242 NM_001025243 NM_001569	IRAK1	interleukin-1 receptor-associated kinase 1
chr17_-_65362635	11.560		PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr4_+_41258941	11.017		UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr16_+_74330660	10.993	NM_002811	PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr19_-_41859253	10.904		TGFB1	transforming growth factor, beta 1
chr2_+_231921595	10.512		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr5_+_159436143	10.372		TTC1	tetratricopeptide repeat domain 1
chr1_-_109968951	10.270		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr17_-_79881304	10.212	NM_032711	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr3_-_149095333	10.136		TM4SF1	transmembrane 4 L six family member 1
chr1_-_154943001	10.005	NM_001130040 NM_183001	SHC1	SHC (Src homology 2 domain containing) transforming protein 1
chr10_+_17270469	9.966		VIM	vimentin
chr1_+_223900226	9.944		CAPN2	calpain 2, (m/II) large subunit
chr7_-_134854225	9.771	NM_001243753 NM_001243755	C7orf49	chromosome 7 open reading frame 49
chr1_-_8931634	9.726	NM_001201483	ENO1	enolase 1, (alpha)
chr9_-_127177689	9.653	NM_002799	PSMB7	proteasome (prosome, macropain) subunit, beta type, 7
chr9_-_113018711	9.556		TXN	thioredoxin
chr15_-_60690115	9.550	NM_001002857 NM_001002858 NM_001136015 NM_004039	ANXA2	annexin A2
chr1_+_110546569	9.505	NM_001242675 NM_001242676	AHCYL1	adenosylhomocysteinase-like 1
chrX_-_153285262	9.430		IRAK1	interleukin-1 receptor-associated kinase 1
chr9_+_33026482	9.425		DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1
chr8_-_12973752	9.204	NM_001164271	DLC1	deleted in liver cancer 1
chrX_-_15511358	9.189		PIR	pirin (iron-binding nuclear protein)
chr5_+_72143929	9.151	NM_153188	TNPO1	transportin 1
chr7_+_112063131	9.113	NM_001007245 NM_001197080	IFRD1	interferon-related developmental regulator 1
chr16_+_30076993	9.086	NM_001243177 NM_184041	ALDOA	aldolase A, fructose-bisphosphate
chr3_-_98241683	9.012		CLDND1	claudin domain containing 1
chr16_+_30077120	9.005		ALDOA	aldolase A, fructose-bisphosphate
chr6_+_44214786	8.987	NM_007355	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr9_-_113018869	8.956	NM_001244938 NM_003329	TXN	thioredoxin
chr7_+_26331493	8.908	NM_001199835 NM_013322	SNX10	sorting nexin 10
chr17_-_76921453	8.865	NM_003255	TIMP2	TIMP metallopeptidase inhibitor 2
chr12_-_76478347	8.852		NAP1L1	nucleosome assembly protein 1-like 1
chr1_+_36621751	8.795	NM_018067	MAP7D1	MAP7 domain containing 1
chr3_-_149095413	8.670		TM4SF1	transmembrane 4 L six family member 1
chr16_+_30077146	8.661		ALDOA	aldolase A, fructose-bisphosphate
chr7_+_116312412	8.618	NM_000245 NM_001127500	MET	met proto-oncogene (hepatocyte growth factor receptor)
chr3_+_69915374	8.613	NM_198177	MITF	microphthalmia-associated transcription factor
chr17_-_65362667	8.604	NM_002816 NM_174871	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr1_-_94374949	8.539		GCLM	glutamate-cysteine ligase, modifier subunit
chr14_+_39649711	8.537		PNN	pinin, desmosome associated protein
chr2_+_231921625	8.487		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr9_-_113018802	8.369		TXN	thioredoxin
chr17_-_38721701	8.309	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr6_+_44214853	8.290		HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr21_+_33031932	8.218	NM_000454	SOD1	superoxide dismutase 1, soluble
chr17_+_18625335	8.182	NM_001037330	TRIM16L	tripartite motif containing 16-like
chr7_+_26331611	8.162		SNX10	sorting nexin 10
chr3_-_149095458	8.079		TM4SF1	transmembrane 4 L six family member 1
chr1_+_174844655	8.016	NM_001035230	RABGAP1L	RAB GTPase activating protein 1-like
chr11_-_47447457	7.978		PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr2_-_85641153	7.931		CAPG	capping protein (actin filament), gelsolin-like
chr9_-_117880411	7.921	NM_002160	TNC	tenascin C
chr6_-_24877453	7.828	NM_015864	FAM65B	family with sequence similarity 65, member B
chr11_+_35160666	7.759		CD44	CD44 molecule (Indian blood group)
chr11_+_118958696	7.732	NM_001024382	HMBS	hydroxymethylbilane synthase
chr11_-_58343308	7.729	NM_004811	LPXN	leupaxin
chr6_+_34206567	7.698	NM_145905	HMGA1	high mobility group AT-hook 1
chr17_-_76921205	7.689		TIMP2	TIMP metallopeptidase inhibitor 2
chr6_-_38670915	7.689		GLO1	glyoxalase I
chr14_+_103801160	7.652	NM_183004	EIF5	eukaryotic translation initiation factor 5
chr6_+_44195008	7.627		SLC29A1	solute carrier family 29 (nucleoside transporters), member 1
chr2_-_85641128	7.618		CAPG	capping protein (actin filament), gelsolin-like
chr1_-_94374986	7.599	NM_002061	GCLM	glutamate-cysteine ligase, modifier subunit
chr6_-_38670904	7.559		GLO1	glyoxalase I
chr6_-_38670871	7.538		GLO1	glyoxalase I
chr6_+_64231626	7.465		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr6_-_24667127	7.441		TDP2	tyrosyl-DNA phosphodiesterase 2
chr1_+_156084565	7.398		LMNA	lamin A/C
chr18_+_55888799	7.385		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_98241748	7.378		CLDND1	claudin domain containing 1
chr22_-_45608232	7.370		KIAA0930	KIAA0930
chr3_+_141043054	7.360	NM_001080412	ZBTB38	zinc finger and BTB domain containing 38
chr18_+_55888838	7.281		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr5_-_137911039	7.143		HSPA9	heat shock 70kDa protein 9 (mortalin)
chr6_-_170862326	7.132		PSMB1	proteasome (prosome, macropain) subunit, beta type, 1
chr6_-_38670882	7.122		GLO1	glyoxalase I
chr14_+_73525267	7.041		RBM25	RNA binding motif protein 25
chr5_-_137911005	6.941		HSPA9	heat shock 70kDa protein 9 (mortalin)
chr4_+_74606222	6.900	NM_000584	IL8	interleukin 8
chr7_+_143058794	6.898		ZYX	zyxin
chr1_+_36621457	6.893		MAP7D1	MAP7 domain containing 1
chr15_+_89182038	6.805	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr11_-_47447779	6.723		PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr3_+_184016985	6.622	NM_002808	PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chrX_-_129244471	6.603	NM_001421	ELF4	E74-like factor 4 (ets domain transcription factor)
chr14_+_73525187	6.603	NM_021239	RBM25	RNA binding motif protein 25
chr12_+_56522043	6.557		ESYT1	extended synaptotagmin-like protein 1
chr7_-_96339074	6.460		SHFM1	split hand/foot malformation (ectrodactyly) type 1
chr12_+_56522202	6.451		ESYT1	extended synaptotagmin-like protein 1
chr19_-_41858948	6.450		TGFB1	transforming growth factor, beta 1
chr5_+_159436155	6.445	NM_003314	TTC1	tetratricopeptide repeat domain 1
chr6_-_159239269	6.392	NM_003379	EZR	ezrin
chr6_-_24666818	6.388	NM_016614	TDP2	tyrosyl-DNA phosphodiesterase 2
chr1_-_36107032	6.383		PSMB2	proteasome (prosome, macropain) subunit, beta type, 2
chr12_-_56359794	6.360	NM_001200053 NM_001200054	PMEL	premelanosome protein
chr12_+_56521953	6.343	NM_001184796 NM_015292	ESYT1	extended synaptotagmin-like protein 1
chr16_+_89988416	6.335	NM_001197181	TUBB3	tubulin, beta 3 class III
chr5_+_179247841	6.302	NM_003900	SQSTM1	sequestosome 1
chr6_-_38670829	6.299		GLO1	glyoxalase I
chr12_-_76478410	6.205		NAP1L1	nucleosome assembly protein 1-like 1
chr12_+_56522049	6.167		ESYT1	extended synaptotagmin-like protein 1
chrX_+_47441650	6.019	NM_003254	TIMP1	TIMP metallopeptidase inhibitor 1
chr12_-_57081961	5.978		PTGES3	prostaglandin E synthase 3 (cytosolic)
chr7_+_22766765	5.976	NM_000600	IL6	interleukin 6 (interferon, beta 2)
chr6_-_84140758	5.950		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_+_184017038	5.945		PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr6_-_159239198	5.942		EZR	ezrin
chr4_-_139163222	5.936	NM_014331	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_+_228332403	5.933	NM_001159391	GUK1	guanylate kinase 1
chr3_+_105085553	5.895	NM_001243280 NM_001243281 NM_001243283 NM_001627	ALCAM	activated leukocyte cell adhesion molecule
chr12_-_57081923	5.889		PTGES3	prostaglandin E synthase 3 (cytosolic)
chr11_-_47447915	5.884	NM_002804	PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr5_+_179247911	5.847		SQSTM1	sequestosome 1
chr4_+_77953942	5.835		SEPT11	septin 11
chr6_+_24667262	5.781	NM_001160094 NM_018473	ACOT13	acyl-CoA thioesterase 13
chr19_-_10450262	5.746	NM_002162	ICAM3	intercellular adhesion molecule 3
chr14_+_103800678	5.673		EIF5	eukaryotic translation initiation factor 5
chr11_+_35160815	5.628		CD44	CD44 molecule (Indian blood group)
chr20_+_33759773	5.615	NM_006404	PROCR	protein C receptor, endothelial
chr5_+_10353980	5.589
chr14_+_73525302	5.573		RBM25	RNA binding motif protein 25
chr11_-_102668822	5.570		MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr1_+_76251878	5.549	NM_004582	RABGGTB	Rab geranylgeranyltransferase, beta subunit
chr12_-_76478737	5.547	NM_004537 NM_139207	NAP1L1	nucleosome assembly protein 1-like 1
chr12_+_64798050	5.533	NM_007235	XPOT	exportin, tRNA (nuclear export receptor for tRNAs)
chr3_+_100238063	5.519		TMEM45A	transmembrane protein 45A
chrX_-_99987072	5.519	NM_001129896	SYTL4	synaptotagmin-like 4
chr11_-_3862137	5.515		RHOG	ras homolog gene family, member G (rho G)
chr2_+_162164993	5.487		PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr6_-_159239254	5.465		EZR	ezrin
chr6_-_170862379	5.463	NM_002793	PSMB1	proteasome (prosome, macropain) subunit, beta type, 1
chr1_-_94375028	5.416		GCLM	glutamate-cysteine ligase, modifier subunit
chr7_+_100770378	5.363	NM_000602 NM_001165413	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr11_-_6640644	5.342		TPP1	tripeptidyl peptidase I
chr11_-_6640661	5.321	NM_000391	TPP1	tripeptidyl peptidase I
chr2_-_216259197	5.316		FN1	fibronectin 1
chr10_+_131934674	5.275		GLRX3	glutaredoxin 3
chr1_-_246580710	5.264	NM_022743	SMYD3	SET and MYND domain containing 3
chr19_+_36630999	5.252		CAPNS1	calpain, small subunit 1
chr10_+_85899184	5.250	NM_014394	GHITM	growth hormone inducible transmembrane protein
chr3_-_149095517	5.241	NM_014220	TM4SF1	transmembrane 4 L six family member 1
chr6_-_84140744	5.227		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr5_+_179247903	5.202		SQSTM1	sequestosome 1
chr21_+_30517897	5.118		C21orf7	chromosome 21 open reading frame 7
chr8_-_102217907	5.095	NM_001042510 NM_016096	ZNF706	zinc finger protein 706
chr12_-_57082056	5.064	NM_006601	PTGES3	prostaglandin E synthase 3 (cytosolic)
chr10_+_121411086	5.054		BAG3	BCL2-associated athanogene 3
chr11_-_6640645	5.001		TPP1	tripeptidyl peptidase I
chr11_-_102668892	4.992	NM_001145938 NM_002421	MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr18_+_55888750	4.972	NM_001144966	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr8_-_30585442	4.939	NM_000637 NM_001195102 NM_001195103 NM_001195104	GSR	glutathione reductase
chr1_+_81771844	4.894		LPHN2	latrophilin 2
chr11_+_35160832	4.866		CD44	CD44 molecule (Indian blood group)
chr11_+_67351276	4.858		GSTP1	glutathione S-transferase pi 1
chr7_+_143078358	4.854	NM_001010972 NM_003461	ZYX	zyxin
chr1_+_156084541	4.846		LMNA	lamin A/C
chr19_+_36631001	4.844		CAPNS1	calpain, small subunit 1
chr7_+_143078447	4.805		ZYX	zyxin
chr11_+_67351065	4.800	NM_000852	GSTP1	glutathione S-transferase pi 1
chr20_+_48807365	4.792		CEBPB	CCAAT/enhancer binding protein (C/EBP), beta
chr7_+_148395886	4.764	NM_003592	CUL1	cullin 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.27	1.08e-16	GO:0009987	cellular process
2.03	1.03e-15	GO:0048522	positive regulation of cellular process
1.95	1.50e-15	GO:0048518	positive regulation of biological process
2.00	9.28e-15	GO:0006950	response to stress
2.65	4.21e-14	GO:0043067	regulation of programmed cell death
2.65	7.78e-14	GO:0042981	regulation of apoptosis
2.61	1.14e-13	GO:0010941	regulation of cell death
1.49	2.96e-13	GO:0050896	response to stimulus
1.44	4.36e-13	GO:0050794	regulation of cellular process
2.56	4.38e-13	GO:0051246	regulation of protein metabolic process
1.65	7.77e-13	GO:0051716	cellular response to stimulus
1.38	2.64e-12	GO:0065007	biological regulation
2.54	8.54e-12	GO:0032268	regulation of cellular protein metabolic process
1.39	1.36e-11	GO:0050789	regulation of biological process
10.06	2.03e-11	GO:0006521	regulation of cellular amino acid metabolic process
8.77	8.29e-11	GO:0071158	positive regulation of cell cycle arrest
2.66	1.64e-10	GO:0044093	positive regulation of molecular function
8.74	3.88e-10	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
8.74	3.88e-10	GO:0072395	signal transduction involved in cell cycle checkpoint
8.74	3.88e-10	GO:0072401	signal transduction involved in DNA integrity checkpoint
8.74	3.88e-10	GO:0072404	signal transduction involved in G1/S transition checkpoint
8.74	3.88e-10	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
8.74	3.88e-10	GO:0072422	signal transduction involved in DNA damage checkpoint
8.74	3.88e-10	GO:0072431	signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
8.74	3.88e-10	GO:0072474	signal transduction involved in mitotic cell cycle G1/S checkpoint
2.65	3.90e-10	GO:0031399	regulation of protein modification process
1.67	4.52e-10	GO:0007165	signal transduction
2.23	1.03e-09	GO:0009893	positive regulation of metabolic process
8.33	1.03e-09	GO:0033238	regulation of cellular amine metabolic process
2.74	1.15e-09	GO:0043085	positive regulation of catalytic activity
7.19	1.52e-09	GO:2000045	regulation of G1/S transition of mitotic cell cycle
2.27	2.87e-09	GO:0010604	positive regulation of macromolecule metabolic process
7.84	3.46e-09	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint
6.85	4.16e-09	GO:0030330	DNA damage response, signal transduction by p53 class mediator
1.41	4.76e-09	GO:0044237	cellular metabolic process
7.19	5.24e-09	GO:0031575	mitotic cell cycle G1/S transition checkpoint
7.19	5.24e-09	GO:0071779	G1/S transition checkpoint
7.51	8.09e-09	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.59	9.37e-09	GO:0023052	signaling
2.43	1.17e-08	GO:0051704	multi-organism process
2.20	1.29e-08	GO:0031325	positive regulation of cellular metabolic process
6.84	1.44e-08	GO:0051351	positive regulation of ligase activity
2.60	1.77e-08	GO:0012501	programmed cell death
3.32	2.00e-08	GO:0032270	positive regulation of cellular protein metabolic process
3.63	2.57e-08	GO:0031401	positive regulation of protein modification process
7.54	2.79e-08	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.60	2.80e-08	GO:0006915	apoptosis
6.92	3.88e-08	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.14	4.23e-08	GO:0002376	immune system process
6.83	4.96e-08	GO:0000216	M/G1 transition of mitotic cell cycle
6.83	4.96e-08	GO:0051443	positive regulation of ubiquitin-protein ligase activity
1.76	5.50e-08	GO:0048519	negative regulation of biological process
7.21	6.25e-08	GO:0051352	negative regulation of ligase activity
7.21	6.25e-08	GO:0051444	negative regulation of ubiquitin-protein ligase activity
2.16	6.41e-08	GO:0050790	regulation of catalytic activity
6.66	8.01e-08	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
3.17	9.09e-08	GO:0051247	positive regulation of protein metabolic process
5.06	1.12e-07	GO:0010565	regulation of cellular ketone metabolic process
2.35	1.16e-07	GO:0009611	response to wounding
2.09	1.38e-07	GO:0010033	response to organic substance
5.97	2.09e-07	GO:0051340	regulation of ligase activity
5.61	2.44e-07	GO:0090068	positive regulation of cell cycle process
4.85	2.93e-07	GO:0000082	G1/S transition of mitotic cell cycle
1.75	3.05e-07	GO:0042221	response to chemical stimulus
2.72	3.24e-07	GO:0050878	regulation of body fluid levels
1.77	3.27e-07	GO:0048523	negative regulation of cellular process
5.51	3.55e-07	GO:0042770	signal transduction in response to DNA damage
2.86	3.63e-07	GO:0007599	hemostasis
5.46	4.26e-07	GO:0000084	S phase of mitotic cell cycle
5.46	4.26e-07	GO:0031398	positive regulation of protein ubiquitination
2.33	4.40e-07	GO:0008219	cell death
4.56	4.76e-07	GO:0010498	proteasomal protein catabolic process
4.56	4.76e-07	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
2.32	5.44e-07	GO:0016265	death
5.36	6.09e-07	GO:0051320	S phase
2.26	6.18e-07	GO:0070887	cellular response to chemical stimulus
1.32	6.34e-07	GO:0008152	metabolic process
5.92	7.11e-07	GO:0051438	regulation of ubiquitin-protein ligase activity
1.36	7.99e-07	GO:0044238	primary metabolic process
2.81	9.50e-07	GO:0007596	blood coagulation
2.81	9.50e-07	GO:0050817	coagulation
3.27	9.71e-07	GO:0051603	proteolysis involved in cellular protein catabolic process
3.66	1.04e-06	GO:0051248	negative regulation of protein metabolic process
2.62	1.15e-06	GO:0042060	wound healing
3.69	1.55e-06	GO:0032269	negative regulation of cellular protein metabolic process
3.21	1.65e-06	GO:0044257	cellular protein catabolic process
5.29	2.02e-06	GO:0000077	DNA damage checkpoint
1.50	2.14e-06	GO:0019222	regulation of metabolic process
5.81	2.94e-06	GO:0031397	negative regulation of protein ubiquitination
4.35	2.95e-06	GO:0031400	negative regulation of protein modification process
3.08	2.95e-06	GO:0030163	protein catabolic process
1.55	3.24e-06	GO:0060255	regulation of macromolecule metabolic process
1.96	3.65e-06	GO:0035556	intracellular signal transduction
1.90	6.02e-06	GO:0065009	regulation of molecular function
4.75	6.03e-06	GO:0007093	mitotic cell cycle checkpoint
4.97	6.50e-06	GO:0031570	DNA integrity checkpoint
2.24	9.94e-06	GO:0033554	cellular response to stress
1.55	1.09e-05	GO:0034641	cellular nitrogen compound metabolic process
2.84	1.14e-05	GO:0043086	negative regulation of catalytic activity
1.54	1.16e-05	GO:0006807	nitrogen compound metabolic process
2.31	1.16e-05	GO:0006955	immune response
4.38	1.24e-05	GO:0031396	regulation of protein ubiquitination
1.50	1.64e-05	GO:0080090	regulation of primary metabolic process
1.63	2.02e-05	GO:0044267	cellular protein metabolic process
3.08	2.41e-05	GO:0019941	modification-dependent protein catabolic process
2.11	2.42e-05	GO:0042127	regulation of cell proliferation
2.56	2.82e-05	GO:0044265	cellular macromolecule catabolic process
3.06	2.84e-05	GO:0043632	modification-dependent macromolecule catabolic process
2.93	3.01e-05	GO:0044419	interspecies interaction between organisms
1.55	3.73e-05	GO:0019538	protein metabolic process
2.41	4.21e-05	GO:0009057	macromolecule catabolic process
3.04	5.20e-05	GO:0006511	ubiquitin-dependent protein catabolic process
3.07	6.87e-05	GO:0034097	response to cytokine stimulus
1.48	7.74e-05	GO:0031323	regulation of cellular metabolic process
2.28	8.26e-05	GO:0019220	regulation of phosphate metabolic process
2.28	8.26e-05	GO:0051174	regulation of phosphorus metabolic process
2.30	8.42e-05	GO:0042325	regulation of phosphorylation
1.56	1.01e-04	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41	1.08e-04	GO:0044260	cellular macromolecule metabolic process
2.31	1.46e-04	GO:0071310	cellular response to organic substance
2.47	1.59e-04	GO:0044092	negative regulation of molecular function
2.50	1.73e-04	GO:0009607	response to biotic stimulus
2.49	1.84e-04	GO:0043065	positive regulation of apoptosis
2.31	2.14e-04	GO:0001932	regulation of protein phosphorylation
2.48	2.20e-04	GO:0043068	positive regulation of programmed cell death
1.80	2.40e-04	GO:0009056	catabolic process
3.11	2.57e-04	GO:0007346	regulation of mitotic cell cycle
1.47	3.42e-04	GO:0016043	cellular component organization
2.43	3.49e-04	GO:0010942	positive regulation of cell death
1.36	3.50e-04	GO:0043170	macromolecule metabolic process
1.88	5.32e-04	GO:0044248	cellular catabolic process
2.28	5.32e-04	GO:0009725	response to hormone stimulus
2.35	6.45e-04	GO:0006928	cellular component movement
2.41	9.36e-04	GO:0001775	cell activation
1.94	1.19e-03	GO:0032879	regulation of localization
2.17	1.21e-03	GO:0009719	response to endogenous stimulus
1.43	1.63e-03	GO:0071840	cellular component organization or biogenesis
1.58	1.67e-03	GO:0065008	regulation of biological quality
3.68	2.20e-03	GO:0030335	positive regulation of cell migration
3.68	2.20e-03	GO:2000147	positive regulation of cell motility
2.80	2.23e-03	GO:0051329	interphase of mitotic cell cycle
3.16	2.49e-03	GO:0000075	cell cycle checkpoint
5.14	2.54e-03	GO:0071216	cellular response to biotic stimulus
3.06	2.66e-03	GO:0030168	platelet activation
2.75	3.16e-03	GO:0051325	interphase
4.38	3.23e-03	GO:0042176	regulation of protein catabolic process
2.86	3.51e-03	GO:0048545	response to steroid hormone stimulus
3.55	3.71e-03	GO:0040017	positive regulation of locomotion
2.79	3.73e-03	GO:0042493	response to drug
2.33	4.05e-03	GO:0043549	regulation of kinase activity
3.85	4.31e-03	GO:0031960	response to corticosteroid stimulus
2.28	4.67e-03	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
2.38	4.76e-03	GO:0060548	negative regulation of cell death
3.04	4.85e-03	GO:0071156	regulation of cell cycle arrest
2.44	5.18e-03	GO:0051707	response to other organism
1.65	5.39e-03	GO:0023051	regulation of signaling
1.63	5.66e-03	GO:0016070	RNA metabolic process
2.26	6.02e-03	GO:0008284	positive regulation of cell proliferation
3.44	6.09e-03	GO:0051272	positive regulation of cellular component movement
3.09	6.39e-03	GO:0006916	anti-apoptosis
2.42	6.50e-03	GO:0007243	intracellular protein kinase cascade
2.42	6.50e-03	GO:0023014	signal transduction via phosphorylation event
2.38	6.57e-03	GO:0043069	negative regulation of programmed cell death
1.96	6.79e-03	GO:0006508	proteolysis
3.56	6.85e-03	GO:0002237	response to molecule of bacterial origin
3.90	7.05e-03	GO:0051384	response to glucocorticoid stimulus
3.70	7.49e-03	GO:0032496	response to lipopolysaccharide
2.25	9.19e-03	GO:0051338	regulation of transferase activity
2.30	1.06e-02	GO:0045859	regulation of protein kinase activity
1.88	1.19e-02	GO:0010605	negative regulation of macromolecule metabolic process
1.39	1.39e-02	GO:0051179	localization
2.33	1.40e-02	GO:0043066	negative regulation of apoptosis
2.21	1.43e-02	GO:0006974	response to DNA damage stimulus
1.90	1.67e-02	GO:0009891	positive regulation of biosynthetic process
1.58	1.72e-02	GO:0007166	cell surface receptor linked signaling pathway
2.00	1.85e-02	GO:0002682	regulation of immune system process
1.96	1.95e-02	GO:0010557	positive regulation of macromolecule biosynthetic process
1.46	2.04e-02	GO:0071842	cellular component organization at cellular level
1.66	2.34e-02	GO:0009966	regulation of signal transduction
1.50	2.41e-02	GO:0090304	nucleic acid metabolic process
2.21	2.47e-02	GO:0006461	protein complex assembly
4.19	2.65e-02	GO:0010952	positive regulation of peptidase activity
1.80	2.75e-02	GO:0009892	negative regulation of metabolic process
1.55	2.80e-02	GO:0048583	regulation of response to stimulus
2.61	2.85e-02	GO:0051270	regulation of cellular component movement
2.19	2.85e-02	GO:0070271	protein complex biogenesis
2.89	3.00e-02	GO:0071345	cellular response to cytokine stimulus
2.35	3.13e-02	GO:0010627	regulation of intracellular protein kinase cascade
2.13	3.15e-02	GO:0016071	mRNA metabolic process
2.65	3.21e-02	GO:0010740	positive regulation of intracellular protein kinase cascade
2.03	3.39e-02	GO:0051726	regulation of cell cycle
4.10	3.41e-02	GO:0000302	response to reactive oxygen species
2.01	3.43e-02	GO:0007167	enzyme linked receptor protein signaling pathway
1.83	3.67e-02	GO:0031324	negative regulation of cellular metabolic process
2.29	3.84e-02	GO:0016477	cell migration
2.92	4.02e-02	GO:0043405	regulation of MAP kinase activity
2.22	4.06e-02	GO:0048870	cell motility
2.22	4.06e-02	GO:0051674	localization of cell
2.67	4.38e-02	GO:0030334	regulation of cell migration
1.86	4.53e-02	GO:0031328	positive regulation of cellular biosynthetic process
3.22	4.78e-02	GO:0050900	leukocyte migration

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
9.80	4.25e-14	GO:0000502	proteasome complex
1.33	6.60e-12	GO:0005737	cytoplasm
1.75	1.72e-07	GO:0005829	cytosol
1.57	7.40e-07	GO:0043234	protein complex
1.17	2.38e-06	GO:0044424	intracellular part
1.33	6.40e-06	GO:0044444	cytoplasmic part
1.16	1.19e-05	GO:0005622	intracellular
1.45	4.53e-05	GO:0032991	macromolecular complex
14.03	4.83e-04	GO:0022624	proteasome accessory complex
1.79	1.09e-03	GO:0000267	cell fraction
9.82	1.15e-03	GO:0005839	proteasome core complex
15.59	1.98e-03	GO:0005838	proteasome regulatory particle
1.85	5.07e-03	GO:0005626	insoluble fraction
5.37	1.12e-02	GO:0031093	platelet alpha granule lumen
5.26	1.34e-02	GO:0034774	secretory granule lumen
1.80	1.78e-02	GO:0005624	membrane fraction
5.05	1.87e-02	GO:0060205	cytoplasmic membrane-bounded vesicle lumen
1.79	2.24e-02	GO:0031982	vesicle
4.86	2.58e-02	GO:0031983	vesicle lumen
1.78	4.00e-02	GO:0031410	cytoplasmic vesicle

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.48	2.09e-19	GO:0005515	protein binding
1.17	1.55e-07	GO:0005488	binding
3.43	2.27e-04	GO:0005126	cytokine receptor binding
2.06	3.21e-04	GO:0019899	enzyme binding
9.35	2.46e-03	GO:0004298	threonine-type endopeptidase activity
9.35	2.46e-03	GO:0070003	threonine-type peptidase activity
7.24	4.42e-03	GO:0015036	disulfide oxidoreductase activity
2.58	1.07e-02	GO:0032403	protein complex binding
1.25	2.23e-02	GO:0003824	catalytic activity
4.95	3.25e-02	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors
1.68	4.47e-02	GO:0005102	receptor binding