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• Activity deltas table
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Motif ID: NFE2L2.p2

Z-value: 2.386

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_30771520	86.684		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771494	61.924	NM_002815	PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771522	61.634		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485	61.267		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr14_+_58711555	55.692		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_30771532	55.319		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_73150769	54.957	NM_001002032 NM_001002033 NM_016185	HN1	hematological and neurological expressed 1
chr14_+_58711457	52.658	NM_002788 NM_152132	PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr14_+_58711599	52.609		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_162164785	52.428	NM_005805	PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr1_-_225616556	51.543	NM_194442	LBR	lamin B receptor
chr18_+_158586	47.360		USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr18_+_158480	46.167	NM_001037334 NM_005151	USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr16_+_30077120	44.925		ALDOA	aldolase A, fructose-bisphosphate
chr16_+_30076993	44.558	NM_001243177 NM_184041	ALDOA	aldolase A, fructose-bisphosphate
chr16_+_30077146	44.096		ALDOA	aldolase A, fructose-bisphosphate
chr6_-_31704304	43.495		CLIC1	chloride intracellular channel 1
chr2_+_231921625	43.218		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr6_-_31704281	42.592		CLIC1	chloride intracellular channel 1
chr6_-_31704272	42.391		CLIC1	chloride intracellular channel 1
chr6_-_31704287	42.340		CLIC1	chloride intracellular channel 1
chr11_-_14541867	41.955		PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chr1_-_109969058	41.645	NM_001199772 NM_002790 NM_001199773 NM_001199774	PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr6_-_31704318	41.427	NM_001288	CLIC1	chloride intracellular channel 1
chr7_-_96339074	39.670		SHFM1	split hand/foot malformation (ectrodactyly) type 1
chr1_-_45987548	38.278	NM_002574 NM_181696 NM_181697	PRDX1	peroxiredoxin 1
chr2_+_162164993	38.264		PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chrX_+_119738542	38.178	NM_001137554	MCTS1	malignant T cell amplified sequence 1
chr11_-_14541886	38.151	NM_001143937 NM_002786	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chr17_-_65362635	38.127		PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr1_-_109969044	37.524		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr10_+_85899184	34.653	NM_014394	GHITM	growth hormone inducible transmembrane protein
chrX_-_109683457	34.174	NM_001171689	AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_-_94374949	33.334		GCLM	glutamate-cysteine ligase, modifier subunit
chr16_+_74330660	33.291	NM_002811	PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr1_-_94374986	33.145	NM_002061	GCLM	glutamate-cysteine ligase, modifier subunit
chr6_+_34206567	33.125	NM_145905	HMGA1	high mobility group AT-hook 1
chr6_-_31704093	32.770		CLIC1	chloride intracellular channel 1
chr11_+_118958696	32.633	NM_001024382	HMBS	hydroxymethylbilane synthase
chr16_-_69760444	32.274	NM_000903 NM_001025433 NM_001025434	NQO1	NAD(P)H dehydrogenase, quinone 1
chr1_-_94375028	30.098		GCLM	glutamate-cysteine ligase, modifier subunit
chr22_+_23010757	30.070
chr1_-_109968951	29.314		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr5_+_159436143	27.803		TTC1	tetratricopeptide repeat domain 1
chr11_-_47447457	27.132		PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr12_-_76478347	26.530		NAP1L1	nucleosome assembly protein 1-like 1
chr2_-_32236104	26.016		MEMO1	mediator of cell motility 1
chr1_+_223889253	25.669	NM_001146068	CAPN2	calpain 2, (m/II) large subunit
chr11_-_47447779	25.012		PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr17_-_79881304	24.994	NM_032711	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr21_+_33031932	24.911	NM_000454	SOD1	superoxide dismutase 1, soluble
chr9_-_113018869	24.590	NM_001244938 NM_003329	TXN	thioredoxin
chr6_-_31704070	24.179		CLIC1	chloride intracellular channel 1
chr7_-_96339171	24.092	NM_006304	SHFM1	split hand/foot malformation (ectrodactyly) type 1
chr7_+_112063131	23.776	NM_001007245 NM_001197080	IFRD1	interferon-related developmental regulator 1
chr2_+_231921608	23.213		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr1_-_246580710	23.146	NM_022743	SMYD3	SET and MYND domain containing 3
chr6_+_44195008	22.882		SLC29A1	solute carrier family 29 (nucleoside transporters), member 1
chr5_+_10353980	22.851
chr18_-_54305657	22.800		TXNL1	thioredoxin-like 1
chr10_+_131934674	22.671		GLRX3	glutaredoxin 3
chr17_-_65362667	22.408	NM_002816 NM_174871	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr3_+_184038050	22.391	NM_004953	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr5_-_137911039	22.371		HSPA9	heat shock 70kDa protein 9 (mortalin)
chr17_+_30677178	21.684		ZNF207	zinc finger protein 207
chr5_-_137911005	21.657		HSPA9	heat shock 70kDa protein 9 (mortalin)
chr3_+_183894736	21.544		AP2M1	adaptor-related protein complex 2, mu 1 subunit
chr22_-_19466725	20.949	NM_001035247 NM_005659	UFD1L	ubiquitin fusion degradation 1 like (yeast)
chr3_+_141043054	20.847	NM_001080412	ZBTB38	zinc finger and BTB domain containing 38
chr19_+_38865184	20.809	NM_002812	PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr7_-_134854225	20.524	NM_001243753 NM_001243755	C7orf49	chromosome 7 open reading frame 49
chr11_-_47447915	20.357	NM_002804	PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr17_+_30677138	20.166	NM_001032293 NM_001098507 NM_003457	ZNF207	zinc finger protein 207
chr19_+_36630999	19.701		CAPNS1	calpain, small subunit 1
chr3_+_184038445	19.636		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr19_+_36630846	19.627	NM_001003962 NM_001749	CAPNS1	calpain, small subunit 1
chr12_-_76478737	19.431	NM_004537 NM_139207	NAP1L1	nucleosome assembly protein 1-like 1
chr6_-_170862326	18.618		PSMB1	proteasome (prosome, macropain) subunit, beta type, 1
chr19_+_36631001	18.487		CAPNS1	calpain, small subunit 1
chr22_-_19466621	18.451		UFD1L	ubiquitin fusion degradation 1 like (yeast)
chr17_+_30677187	18.189		ZNF207	zinc finger protein 207
chr6_+_150070856	18.167		PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr7_-_102985068	18.149	NM_001129887 NM_014377	DNAJC2	DnaJ (Hsp40) homolog, subfamily C, member 2
chr1_-_150208441	17.954		ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_6445737	17.882	NM_181864	ACOT7	acyl-CoA thioesterase 7
chr6_-_35888816	17.650		SRPK1	SRSF protein kinase 1
chr4_+_39699663	17.601	NM_001111112 NM_001111113 NM_005339	UBE2K	ubiquitin-conjugating enzyme E2K
chr3_+_184016985	17.563	NM_002808	PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr12_-_76478410	17.409		NAP1L1	nucleosome assembly protein 1-like 1
chr11_-_16996559	17.157		RPL36A	ribosomal protein L36a
chr20_+_44637539	17.105	NM_004994	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr17_+_79650961	16.707	NM_004712	HGS	hepatocyte growth factor-regulated tyrosine kinase substrate
chr5_-_95158465	16.682	NM_001118890 NM_001243658 NM_001243659 NM_002064	GLRX	glutaredoxin (thioltransferase)
chr1_-_150208462	16.672	NM_001136478 NM_030920	ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_+_110546569	16.571	NM_001242675 NM_001242676	AHCYL1	adenosylhomocysteinase-like 1
chr6_-_24719286	16.435	NM_030939	C6orf62	chromosome 6 open reading frame 62
chr5_-_150727088	16.429	NM_181776	SLC36A2	solute carrier family 36 (proton/amino acid symporter), member 2
chr19_-_2038937	16.382		MKNK2	MAP kinase interacting serine/threonine kinase 2
chr12_-_53343607	16.184		KRT8	keratin 8
chr17_+_75372164	16.181	NM_001113494	SEPT9	septin 9
chr14_+_103800678	16.036		EIF5	eukaryotic translation initiation factor 5
chr17_+_79651042	16.022		HGS	hepatocyte growth factor-regulated tyrosine kinase substrate
chr12_+_64798050	15.708	NM_007235	XPOT	exportin, tRNA (nuclear export receptor for tRNAs)
chrX_-_15511710	15.674	NM_001018109 NM_003662	PIR	pirin (iron-binding nuclear protein)
chr17_+_79651035	15.584		HGS	hepatocyte growth factor-regulated tyrosine kinase substrate
chr1_-_154943001	15.558	NM_001130040 NM_183001	SHC1	SHC (Src homology 2 domain containing) transforming protein 1
chr15_+_89182038	15.526	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr17_+_28707495	15.085	NM_001199775	CPD	carboxypeptidase D
chr3_-_128902672	15.041		CNBP	CCHC-type zinc finger, nucleic acid binding protein
chrX_-_15511358	14.999		PIR	pirin (iron-binding nuclear protein)
chr16_+_74330730	14.982		PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr5_-_95158365	14.950		GLRX	glutaredoxin (thioltransferase)
chr13_+_29233279	14.906		POMP	proteasome maturation protein
chr3_+_184017038	14.863		PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr12_-_57030083	14.642	NM_013449	BAZ2A	bromodomain adjacent to zinc finger domain, 2A
chr3_-_128902764	14.588	NM_001127192 NM_001127193 NM_001127194 NM_001127195 NM_001127196 NM_003418	CNBP	CCHC-type zinc finger, nucleic acid binding protein
chr13_+_29233140	14.573	NM_015932	POMP	proteasome maturation protein
chr7_+_130794854	14.511	NM_001145354	MKLN1	muskelin 1, intracellular mediator containing kelch motifs
chr6_-_35888937	14.468	NM_003137	SRPK1	SRSF protein kinase 1
chr8_-_59572403	14.454	NM_003580	NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor
chr22_+_45072687	14.402	NM_001017530 NM_001198721 NM_015366	PRR5	proline rich 5 (renal)
chr18_-_54305839	14.400	NM_004786	TXNL1	thioredoxin-like 1
chr6_+_150070818	14.071	NM_001252049 NM_001252050 NM_001252051 NM_001252052 NM_001252053 NM_005389	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr8_-_59572385	13.931		NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor
chr9_+_140135698	13.895	NM_006088	TUBB4B	tubulin, beta 4B class IVb
chr22_-_45608232	13.779		KIAA0930	KIAA0930
chr16_+_89988416	13.652	NM_001197181	TUBB3	tubulin, beta 3 class III
chr7_+_148395886	13.579	NM_003592	CUL1	cullin 1
chr6_-_24877453	13.379	NM_015864	FAM65B	family with sequence similarity 65, member B
chr19_+_34855594	13.378	NM_001184722 NM_000175	GPI	glucose-6-phosphate isomerase
chr2_+_231921595	13.352		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr9_+_140135738	13.201		TUBB4B	tubulin, beta 4B class IVb
chr9_-_113018711	13.150		TXN	thioredoxin
chr6_-_84140744	12.969		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr21_-_46237882	12.959		SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr11_+_62649160	12.947		SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr5_+_159436155	12.760	NM_003314	TTC1	tetratricopeptide repeat domain 1
chr9_+_130922471	12.736	NM_024112	C9orf16	chromosome 9 open reading frame 16
chr8_-_59571920	12.644	NM_001144772	NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor
chr7_+_148396016	12.490		CUL1	cullin 1
chr6_+_44214853	12.444		HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr22_+_45072936	12.383		PRR5	proline rich 5 (renal)
chr19_+_34856155	12.357		GPI	glucose-6-phosphate isomerase
chr17_+_18625335	12.113	NM_001037330	TRIM16L	tripartite motif containing 16-like
chr17_+_61905043	12.043	NM_001199163	PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr21_-_46237966	11.991		SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr2_+_231921562	11.885	NM_001191037 NM_002807	PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr1_-_33366838	11.880	NM_033504	TMEM54	transmembrane protein 54
chr6_+_44214786	11.770	NM_007355	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_-_150208134	11.729		ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr17_-_28618836	11.676		BLMH	bleomycin hydrolase
chr10_+_121411086	11.641		BAG3	BCL2-associated athanogene 3
chr20_+_55043682	11.582		C20orf43	chromosome 20 open reading frame 43
chr19_+_34856123	11.538		GPI	glucose-6-phosphate isomerase
chr7_-_42971730	11.279		PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2
chr17_-_61905030	11.248	NM_017647	FTSJ3	FtsJ homolog 3 (E. coli)
chr6_+_150070844	11.178		PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_+_40506254	11.142	NM_001105530 NM_006367	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr21_-_33651324	11.013	NM_018944	MIS18A	MIS18 kinetochore protein homolog A (S. pombe)
chr9_-_113018802	10.923		TXN	thioredoxin
chr12_+_64803741	10.912		XPOT	exportin, tRNA (nuclear export receptor for tRNAs)
chr6_-_84140758	10.842		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr8_-_59572188	10.770		NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor
chr2_-_32236053	10.710		MEMO1	mediator of cell motility 1
chr10_-_75173789	10.629		ANXA7	annexin A7
chr7_+_148395995	10.447		CUL1	cullin 1
chr17_-_28619183	10.337	NM_000386	BLMH	bleomycin hydrolase
chr1_+_40506423	10.326		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr16_+_22308722	10.320	NM_018119	POLR3E	polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr1_-_52344377	10.293		NRD1	nardilysin (N-arginine dibasic convertase)
chr6_-_33548017	10.260	NM_001188	BAK1	BCL2-antagonist/killer 1
chr5_+_179247841	10.232	NM_003900	SQSTM1	sequestosome 1
chr12_-_15114495	10.206	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr17_+_79651072	10.197		HGS	hepatocyte growth factor-regulated tyrosine kinase substrate
chr10_+_131934637	10.138	NM_001199868 NM_006541	GLRX3	glutaredoxin 3
chr17_+_80193649	9.941	NM_001206952	SLC16A3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr15_+_44829265	9.847	NM_003758	EIF3J	eukaryotic translation initiation factor 3, subunit J
chr2_+_86668488	9.769	NM_001146688	KDM3A	lysine (K)-specific demethylase 3A
chr17_-_76921453	9.730	NM_003255	TIMP2	TIMP metallopeptidase inhibitor 2
chr22_-_32808142	9.725		C22orf28	chromosome 22 open reading frame 28
chr1_+_151227209	9.675		PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr6_+_64281910	9.650	NM_003463	PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr2_-_65593866	9.510	NM_001128210	SPRED2	sprouty-related, EVH1 domain containing 2
chr1_+_40506384	9.489		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr13_-_41593405	9.430		ELF1	E74-like factor 1 (ets domain transcription factor)
chr7_+_116312412	9.424	NM_000245 NM_001127500	MET	met proto-oncogene (hepatocyte growth factor receptor)
chr7_-_100881030	9.258	NM_014343	CLDN15	claudin 15
chr2_+_74057969	9.212		STAMBP	STAM binding protein
chr20_+_55043712	9.208		C20orf43	chromosome 20 open reading frame 43
chr20_+_55043691	9.188		C20orf43	chromosome 20 open reading frame 43
chr6_+_64231626	9.003		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr1_+_40506436	8.903		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr1_+_40506449	8.800		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr1_+_40506406	8.711		CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr17_+_57697036	8.699	NM_004859	CLTC	clathrin, heavy chain (Hc)
chr14_-_106791054	8.679		IGHV4-31 IGHV3-30 IGHA1 IGHD IGHG1 IGHG2 IGHG3 IGHM SCFV	immunoglobulin heavy variable 4-31 immunoglobulin heavy variable 3-30 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant delta immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 2 (G2m marker) immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu single-chain Fv fragment
chr5_+_172410762	8.617	NM_003945	ATP6V0E1	ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr16_-_28621279	8.582	NM_001055 NM_177529	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr15_+_78832787	8.487		PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4
chr16_-_1429612	8.345	NM_001193389 NM_023076	UNKL	unkempt homolog (Drosophila)-like

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
15.35	6.78e-17	GO:0006521	regulation of cellular amino acid metabolic process
11.34	5.61e-16	GO:0051351	positive regulation of ligase activity
12.53	1.51e-15	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint
13.34	2.15e-15	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
13.34	2.15e-15	GO:0072395	signal transduction involved in cell cycle checkpoint
13.34	2.15e-15	GO:0072401	signal transduction involved in DNA integrity checkpoint
13.34	2.15e-15	GO:0072404	signal transduction involved in G1/S transition checkpoint
13.34	2.15e-15	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
13.34	2.15e-15	GO:0072422	signal transduction involved in DNA damage checkpoint
13.34	2.15e-15	GO:0072431	signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
13.34	2.15e-15	GO:0072474	signal transduction involved in mitotic cell cycle G1/S checkpoint
11.42	2.59e-15	GO:0051443	positive regulation of ubiquitin-protein ligase activity
9.33	4.04e-15	GO:0031398	positive regulation of protein ubiquitination
12.00	4.37e-15	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
12.71	6.74e-15	GO:0033238	regulation of cellular amine metabolic process
12.71	6.74e-15	GO:0071158	positive regulation of cell cycle arrest
10.87	9.06e-15	GO:2000045	regulation of G1/S transition of mitotic cell cycle
9.89	1.89e-14	GO:0051340	regulation of ligase activity
11.07	3.10e-14	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
10.93	4.21e-14	GO:0031575	mitotic cell cycle G1/S transition checkpoint
10.93	4.21e-14	GO:0071779	G1/S transition checkpoint
10.65	7.68e-14	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
9.90	8.89e-14	GO:0051438	regulation of ubiquitin-protein ligase activity
11.56	3.49e-13	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
10.43	6.42e-13	GO:0000216	M/G1 transition of mitotic cell cycle
11.07	9.07e-13	GO:0051352	negative regulation of ligase activity
11.07	9.07e-13	GO:0051444	negative regulation of ubiquitin-protein ligase activity
7.14	4.29e-12	GO:0031396	regulation of protein ubiquitination
8.41	4.33e-12	GO:0000077	DNA damage checkpoint
9.46	5.58e-12	GO:0030330	DNA damage response, signal transduction by p53 class mediator
8.25	6.68e-12	GO:0000084	S phase of mitotic cell cycle
8.10	1.02e-11	GO:0051320	S phase
7.89	1.89e-11	GO:0031570	DNA integrity checkpoint
6.54	3.88e-11	GO:0010498	proteasomal protein catabolic process
6.54	3.88e-11	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
8.91	8.87e-11	GO:0031397	negative regulation of protein ubiquitination
7.19	1.55e-10	GO:0007093	mitotic cell cycle checkpoint
7.75	3.94e-10	GO:0090068	positive regulation of cell cycle process
7.60	5.82e-10	GO:0042770	signal transduction in response to DNA damage
6.70	7.32e-10	GO:0010565	regulation of cellular ketone metabolic process
4.26	1.71e-09	GO:0051603	proteolysis involved in cellular protein catabolic process
4.18	2.96e-09	GO:0044257	cellular protein catabolic process
4.34	5.15e-09	GO:0031401	positive regulation of protein modification process
6.13	1.49e-08	GO:0000082	G1/S transition of mitotic cell cycle
1.24	1.71e-08	GO:0009987	cellular process
3.91	1.97e-08	GO:0030163	protein catabolic process
5.75	1.98e-08	GO:0031400	negative regulation of protein modification process
4.12	2.03e-08	GO:0019941	modification-dependent protein catabolic process
4.09	2.42e-08	GO:0043632	modification-dependent macromolecule catabolic process
4.07	5.77e-08	GO:0006511	ubiquitin-dependent protein catabolic process
3.71	8.24e-08	GO:0032270	positive regulation of cellular protein metabolic process
1.45	8.38e-08	GO:0044237	cellular metabolic process
3.21	1.41e-07	GO:0044265	cellular macromolecule catabolic process
4.29	1.56e-07	GO:0007346	regulation of mitotic cell cycle
4.75	1.80e-07	GO:0000075	cell cycle checkpoint
2.45	2.71e-07	GO:0042981	regulation of apoptosis
2.67	2.73e-07	GO:0044093	positive regulation of molecular function
3.54	2.91e-07	GO:0051247	positive regulation of protein metabolic process
2.33	3.46e-07	GO:0050790	regulation of catalytic activity
2.43	3.78e-07	GO:0043067	regulation of programmed cell death
4.00	3.87e-07	GO:0051329	interphase of mitotic cell cycle
4.57	4.14e-07	GO:0071156	regulation of cell cycle arrest
2.81	4.38e-07	GO:0043085	positive regulation of catalytic activity
3.93	5.88e-07	GO:0051325	interphase
2.39	6.97e-07	GO:0010941	regulation of cell death
4.23	9.76e-07	GO:0051248	negative regulation of protein metabolic process
2.91	1.01e-06	GO:0009057	macromolecule catabolic process
1.37	1.94e-06	GO:0008152	metabolic process
4.25	1.94e-06	GO:0032269	negative regulation of cellular protein metabolic process
2.55	3.08e-06	GO:0006508	proteolysis
1.39	1.10e-05	GO:0044238	primary metabolic process
2.59	1.33e-05	GO:0012501	programmed cell death
2.04	1.80e-05	GO:0065009	regulation of molecular function
2.80	1.91e-05	GO:0000278	mitotic cell cycle
1.62	2.20e-05	GO:0006807	nitrogen compound metabolic process
3.36	2.23e-05	GO:0044419	interspecies interaction between organisms
2.28	2.26e-05	GO:0032268	regulation of cellular protein metabolic process
2.57	2.49e-05	GO:0006915	apoptosis
2.22	2.82e-05	GO:0051246	regulation of protein metabolic process
3.16	2.83e-05	GO:0016032	viral reproduction
3.36	3.86e-05	GO:0010564	regulation of cell cycle process
1.62	4.12e-05	GO:0034641	cellular nitrogen compound metabolic process
2.16	4.46e-05	GO:0044248	cellular catabolic process
2.43	6.49e-05	GO:0031399	regulation of protein modification process
2.30	1.15e-04	GO:0051704	multi-organism process
1.48	1.42e-04	GO:0044260	cellular macromolecule metabolic process
1.65	1.54e-04	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.19	1.55e-04	GO:0007049	cell cycle
2.09	2.33e-04	GO:0010604	positive regulation of macromolecule metabolic process
1.43	2.48e-04	GO:0043170	macromolecule metabolic process
1.95	2.57e-04	GO:0009056	catabolic process
2.27	3.03e-04	GO:0008219	cell death
2.26	3.51e-04	GO:0016265	death
1.68	4.48e-04	GO:0006950	response to stress
1.59	4.88e-04	GO:0019538	protein metabolic process
1.66	5.17e-04	GO:0044267	cellular protein metabolic process
2.03	5.89e-04	GO:0031325	positive regulation of cellular metabolic process
1.99	7.39e-04	GO:0009893	positive regulation of metabolic process
2.63	1.10e-03	GO:0006974	response to DNA damage stimulus
2.46	1.12e-03	GO:0051726	regulation of cell cycle
2.37	1.35e-03	GO:0022403	cell cycle phase
2.81	1.54e-03	GO:0043086	negative regulation of catalytic activity
2.23	1.84e-03	GO:0022402	cell cycle process
1.63	3.15e-03	GO:0048519	negative regulation of biological process
2.17	3.78e-03	GO:0033554	cellular response to stress
1.75	4.52e-03	GO:0016070	RNA metabolic process
1.91	4.55e-03	GO:0002376	immune system process
1.65	5.97e-03	GO:0048523	negative regulation of cellular process
2.46	6.65e-03	GO:0016071	mRNA metabolic process
1.63	8.33e-03	GO:0090304	nucleic acid metabolic process
2.88	9.89e-03	GO:0009894	regulation of catabolic process
5.87	1.07e-02	GO:0045454	cell redox homeostasis
2.44	1.16e-02	GO:0044092	negative regulation of molecular function
1.53	1.59e-02	GO:0048518	positive regulation of biological process
1.56	2.18e-02	GO:0048522	positive regulation of cellular process
1.29	3.24e-02	GO:0050896	response to stimulus
1.39	3.74e-02	GO:0051716	cellular response to stimulus
3.67	4.73e-02	GO:0050900	leukocyte migration

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
15.37	2.84e-21	GO:0000502	proteasome complex
1.38	4.48e-11	GO:0005737	cytoplasm
1.20	2.97e-07	GO:0005622	intracellular
1.20	3.25e-06	GO:0044424	intracellular part
15.49	4.70e-06	GO:0005839	proteasome core complex
1.77	1.71e-05	GO:0005829	cytosol
1.57	1.45e-04	GO:0043234	protein complex
24.21	1.54e-04	GO:0019773	proteasome core complex, alpha-subunit complex
21.52	3.38e-04	GO:0005838	proteasome regulatory particle
16.14	1.99e-03	GO:0022624	proteasome accessory complex
1.44	2.50e-03	GO:0032991	macromolecular complex
1.27	1.87e-02	GO:0044444	cytoplasmic part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.46	2.66e-12	GO:0005515	protein binding
1.18	5.38e-06	GO:0005488	binding
14.76	1.04e-05	GO:0004298	threonine-type endopeptidase activity
14.76	1.04e-05	GO:0070003	threonine-type peptidase activity
9.69	1.88e-05	GO:0003823	antigen binding
8.75	4.12e-03	GO:0015036	disulfide oxidoreductase activity
6.08	1.64e-02	GO:0005097	Rab GTPase activator activity
2.82	1.93e-02	GO:0032403	protein complex binding
2.51	2.03e-02	GO:0004175	endopeptidase activity
29.05	2.43e-02	GO:0015037	peptide disulfide oxidoreductase activity
8.30	2.44e-02	GO:0015035	protein disulfide oxidoreductase activity
2.15	3.01e-02	GO:0008233	peptidase activity