Motif ID: NFIX.p2

Z-value: 1.920


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFIXchr19_+_131347820.244.0e-04Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_150399980 38.927 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr5_+_150400132 38.038 GPX3
glutathione peroxidase 3 (plasma)
chr10_+_124220990 22.255 NM_002775
HTRA1
HtrA serine peptidase 1
chr15_-_72668184 19.994 HEXA
hexosaminidase A (alpha polypeptide)
chr9_+_124030370 19.182 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr9_+_124030455 18.890 GSN
gelsolin
chr11_-_72353435 18.288 NM_001143839
NM_001243784
PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr11_-_46722160 17.311 ARHGAP1
Rho GTPase activating protein 1
chr12_+_26348268 16.790 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr18_-_74691951 16.206 MBP
myelin basic protein
chr11_-_46722139 16.099 ARHGAP1
Rho GTPase activating protein 1
chr9_+_124030413 16.059 GSN
gelsolin
chr17_+_37844325 16.012 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr11_-_61735108 14.822 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr17_-_37844266 14.793 NM_033419
PGAP3
post-GPI attachment to proteins 3
chr15_+_91769329 14.565 SV2B
synaptic vesicle glycoprotein 2B
chr10_+_88728187 14.263 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr20_-_44539542 13.805 PLTP
phospholipid transfer protein
chr1_-_36235422 13.693 NM_001190481
NM_022111
CLSPN

claspin

chr11_-_46722115 13.682 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr1_-_2322996 13.271 MORN1
MORN repeat containing 1
chr1_+_44584521 13.097 NM_173484
KLF17
Kruppel-like factor 17
chrX_+_13671224 12.887 NM_152634
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr16_-_4852571 12.782 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr8_+_24771268 12.395 NM_005382
NEFM
neurofilament, medium polypeptide
chr3_-_50396892 11.949 TMEM115
transmembrane protein 115
chr1_+_1260289 11.893


chr11_-_57004674 11.753 NM_005161
APLNR
apelin receptor
chr1_-_2322990 11.568 NM_024848
MORN1
MORN repeat containing 1
chr9_+_35605339 11.450 TESK1
testis-specific kinase 1
chr8_+_24771276 11.283 NEFM
neurofilament, medium polypeptide
chr3_-_28390506 11.280 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr11_-_61735067 11.204 FTH1
CPSF7
ferritin, heavy polypeptide 1
cleavage and polyadenylation specific factor 7, 59kDa
chr9_+_35605275 10.993 NM_006285
TESK1
testis-specific kinase 1
chr17_-_28562953 10.978 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr17_-_79105747 10.975 NM_004920
AATK
apoptosis-associated tyrosine kinase
chr7_+_108210291 10.811 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr17_-_80656461 10.694 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr11_-_12030128 10.418 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr11_-_61734896 10.373 FTH1
ferritin, heavy polypeptide 1
chr7_+_108210308 10.363 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr13_+_48807307 10.277 ITM2B
integral membrane protein 2B
chr9_+_130911731 10.243 NM_005564
LCN2
lipocalin 2
chr3_-_50396930 10.132 NM_007024
TMEM115
transmembrane protein 115
chr3_+_130745693 10.076 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr1_-_156217717 10.057 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr11_-_125366048 9.774 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr3_-_42003460 9.632 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chr2_+_39664544 9.562 LOC728730
uncharacterized LOC728730
chr3_-_28390280 9.536 AZI2
5-azacytidine induced 2
chr9_-_94124149 9.486 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr19_-_11373117 9.369 NM_020812
DOCK6
dedicator of cytokinesis 6
chr10_-_100206643 9.300 HPS1
Hermansky-Pudlak syndrome 1
chr17_+_18128868 9.297 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr9_+_34179058 9.275 UBAP1
ubiquitin associated protein 1
chr6_+_41040713 9.262 NFYA
nuclear transcription factor Y, alpha
chr19_-_3028901 9.245 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr3_+_138067678 9.228 NM_001252092
MRAS
muscle RAS oncogene homolog
chr12_-_45270071 9.075 NELL2
NEL-like 2 (chicken)
chr7_+_108210188 9.069 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr3_+_133495925 9.056 TF
transferrin
chr10_-_7661613 9.037 NM_032817
ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr9_-_130616592 8.949 ENG
endoglin
chr16_+_29985185 8.897 NM_001252043
NM_004783
NM_016151
TAOK2


TAO kinase 2


chr12_+_51985016 8.837 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr15_+_74466887 8.832 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr6_+_30851860 8.721 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_-_109330190 8.702 NM_001199934
SESN1
sestrin 1
chrX_+_21857786 8.634 MBTPS2
membrane-bound transcription factor peptidase, site 2
chr7_+_156742402 8.574 NM_138400
NOM1
nucleolar protein with MIF4G domain 1
chr3_+_138067969 8.514 NM_001252090
MRAS
muscle RAS oncogene homolog
chrX_+_21857775 8.506


chr9_+_34179036 8.493 UBAP1
ubiquitin associated protein 1
chr11_-_117166247 8.452 NM_001207048
NM_001207049
BACE1

beta-site APP-cleaving enzyme 1

chr8_-_11725509 8.280 CTSB
cathepsin B
chr3_+_138067444 8.245 NM_001085049
NM_001252093
MRAS

muscle RAS oncogene homolog

chr11_-_12030539 8.221 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr9_+_34179002 8.205 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chr6_-_46459010 8.090 NM_001251974
RCAN2
regulator of calcineurin 2
chr19_+_30156326 7.973 NM_024310
PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr2_+_241375030 7.958 NM_002081
GPC1
glypican 1
chr3_+_35681008 7.907 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_+_53443834 7.905 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_-_99579540 7.821 NM_005723
TSPAN5
tetraspanin 5
chr19_-_6720585 7.811 NM_000064
C3
complement component 3
chr5_+_23507723 7.798 NM_020227
PRDM9
PR domain containing 9
chrX_+_21857745 7.711 MBTPS2
membrane-bound transcription factor peptidase, site 2
chr9_+_34179023 7.625 UBAP1
ubiquitin associated protein 1
chr9_+_115913227 7.512 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr8_-_33424642 7.475 NM_024787
RNF122
ring finger protein 122
chr4_+_3294711 7.459 RGS12
regulator of G-protein signaling 12
chr1_+_115397454 7.332 NM_003176
SYCP1
synaptonemal complex protein 1
chr11_+_64851691 7.327 NM_006782
ZFPL1
zinc finger protein-like 1
chr16_+_56703725 7.049 NM_005951
MT1H
metallothionein 1H
chr22_-_36019363 7.037 NM_203377
MB
myoglobin
chr12_+_108909049 6.994 NM_007076
FICD
FIC domain containing
chr10_+_73079044 6.881 SLC29A3
solute carrier family 29 (nucleoside transporters), member 3
chr9_-_113800243 6.798 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr13_+_27131879 6.794 WASF3
WAS protein family, member 3
chr10_+_38299525 6.742 NM_006954
NM_006974
ZNF33A

zinc finger protein 33A

chr10_-_105992062 6.686 NM_025145
WDR96
WD repeat domain 96
chr9_-_130616760 6.664 ENG
endoglin
chr13_+_48807492 6.579 ITM2B
integral membrane protein 2B
chr8_-_7212868 6.539 FAM66B
family with sequence similarity 66, member B
chr16_+_29985213 6.528 TAOK2
TAO kinase 2
chr4_-_85419386 6.447 NM_006168
NKX6-1
NK6 homeobox 1
chr9_+_133320093 6.445 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr1_+_77333121 6.443 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr8_-_11725587 6.432 CTSB
cathepsin B
chr21_-_48024985 6.418 NM_006272
S100B
S100 calcium binding protein B
chr11_-_12030622 6.407 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_+_45312294 6.350 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr22_+_19701968 6.269 NM_002688
SEPT5
septin 5
chr12_+_50355278 6.249 NM_001651
AQP5
aquaporin 5
chr6_-_109330752 6.196 NM_001199933
SESN1
sestrin 1
chrX_+_21857655 6.194 NM_015884
MBTPS2
membrane-bound transcription factor peptidase, site 2
chr15_+_67358161 6.175 SMAD3
SMAD family member 3
chr22_-_36903033 6.166 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chrX_+_10124984 6.111 NM_001830
CLCN4
chloride channel 4
chr22_-_44258210 6.062 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr11_-_64527369 6.039 PYGM
phosphorylase, glycogen, muscle
chr10_+_73079009 6.027 NM_001174098
NM_018344
SLC29A3

solute carrier family 29 (nucleoside transporters), member 3

chr2_+_3642421 5.993 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr4_-_8442427 5.972 NM_001101667
NM_003501
ACOX3

acyl-CoA oxidase 3, pristanoyl

chr13_-_77460432 5.969 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr9_+_133320247 5.957 ASS1
argininosuccinate synthase 1
chr2_+_149632772 5.937 NM_004522
KIF5C
kinesin family member 5C
chr2_-_232395108 5.917 NM_006056
NMUR1
neuromedin U receptor 1
chr6_+_41040687 5.910 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chr5_-_1634099 5.865 LOC728613
programmed cell death 6 pseudogene
chr13_+_48807250 5.841 NM_021999
ITM2B
integral membrane protein 2B
chrX_-_102319096 5.747 NM_018476
BEX1
brain expressed, X-linked 1
chr5_+_141303463 5.745 KIAA0141
KIAA0141
chr16_+_1290677 5.715 NM_003294
TPSB2
TPSAB1
tryptase beta 2 (gene/pseudogene)
tryptase alpha/beta 1
chr9_-_94124194 5.663 NM_001698
AUH
AU RNA binding protein/enoyl-CoA hydratase
chr11_-_64528186 5.655 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr4_-_73935408 5.647 NM_173827
COX18
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr4_+_1795004 5.572 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr19_+_38893828 5.535 FAM98C
family with sequence similarity 98, member C
chr16_-_30905262 5.499 BCL7C
B-cell CLL/lymphoma 7C
chr3_+_44596596 5.485 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr11_-_49229878 5.459 FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
chr1_+_46859918 5.410 NM_001441
FAAH
fatty acid amide hydrolase
chr2_-_223163333 5.363 NM_000438
NM_001127366
NM_013942
NM_181457
NM_181458
NM_181459
NM_181460
NM_181461
PAX3







paired box 3







chr12_+_26348488 5.361 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_-_236228476 5.359 NM_002508
NID1
nidogen 1
chr19_+_46195898 5.330 QPCTL
glutaminyl-peptide cyclotransferase-like
chr8_+_11142314 5.316 MTMR9
myotubularin related protein 9
chr19_+_859658 5.308 NM_001928
CFD
complement factor D (adipsin)
chr12_-_45269953 5.307 NELL2
NEL-like 2 (chicken)
chr3_-_160822625 5.282 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr8_+_75262616 5.229 NM_018972
NM_001040875
GDAP1

ganglioside-induced differentiation-associated protein 1

chr4_-_109684053 5.228 NM_001146590
NM_001146627
NM_031279
AGXT2L1


alanine-glyoxylate aminotransferase 2-like 1


chr16_+_66968390 5.227 CES2
carboxylesterase 2
chr1_+_77333158 5.198 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr9_-_130616957 5.194 ENG
endoglin
chr2_+_149633173 5.194


chr2_-_56151273 5.075 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr16_-_89556886 5.070 NM_013275
ANKRD11
ankyrin repeat domain 11
chr6_-_109761707 5.063 PPIL6
peptidylprolyl isomerase (cyclophilin)-like 6
chr17_-_34890610 5.043 MYO19
myosin XIX
chr2_+_149632836 5.043 KIF5C
kinesin family member 5C
chr17_+_32597239 5.024 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr19_+_57791794 4.999 NM_006635
ZNF460
zinc finger protein 460
chr5_-_157002705 4.995


chr20_+_43344005 4.977 WISP2
WNT1 inducible signaling pathway protein 2
chr3_-_46506342 4.977 NM_002343
LTF
lactotransferrin
chr15_-_71184611 4.972 NM_020147
THAP10
THAP domain containing 10
chr9_+_104161118 4.970 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr4_+_156680125 4.956 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr1_-_13390747 4.915 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr17_+_18012019 4.903 NM_016239
MYO15A
myosin XVA
chr8_-_11725622 4.895 CTSB
cathepsin B
chr15_-_72668301 4.894 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr5_+_141303366 4.870 NM_001142603
NM_014773
KIAA0141

KIAA0141

chr19_+_38755097 4.820 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr14_-_93582143 4.809 NM_001142593
NM_001142594
NM_014216
ITPK1


inositol-tetrakisphosphate 1-kinase


chr8_-_41166931 4.806 NM_003012
SFRP1
secreted frizzled-related protein 1
chr2_-_71221951 4.780 TEX261
testis expressed 261
chr16_-_30546145 4.759 NM_023931
ZNF747
zinc finger protein 747
chr7_-_150038689 4.748 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr3_+_10290204 4.725 TATDN2
TatD DNase domain containing 2
chr5_+_140797270 4.693 PCDHGB7
protocadherin gamma subfamily B, 7
chr15_-_26874236 4.652 NM_001191321
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chrX_-_102319080 4.645 BEX1
brain expressed, X-linked 1
chr3_-_16646244 4.644 NM_001190811
DAZL
deleted in azoospermia-like
chr1_-_182360889 4.631 GLUL
glutamate-ammonia ligase
chr8_-_54755821 4.616 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr14_-_93651182 4.614 MOAP1
modulator of apoptosis 1
chr1_+_244816434 4.591 PPPDE1
PPPDE peptidase domain containing 1
chr13_+_28494136 4.564 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr13_-_20357081 4.559 PSPC1
paraspeckle component 1
chr20_-_32262168 4.545 NECAB3
N-terminal EF-hand calcium binding protein 3
chr14_-_106208695 4.537


chr1_+_10003485 4.537 NM_022787
NMNAT1
nicotinamide nucleotide adenylyltransferase 1
chr6_+_31795395 4.516 NM_005346
HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr3_+_184279539 4.515 NM_004443
EPHB3
EPH receptor B3
chr4_-_120548329 4.478 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chr12_+_72666462 4.431 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr10_+_11784355 4.401 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 1.93e-12 GO:0009987 cellular process
1.37 1.62e-06 GO:0023052 signaling
1.21 2.73e-06 GO:0065007 biological regulation
1.20 4.69e-05 GO:0050789 regulation of biological process
1.20 4.20e-04 GO:0050794 regulation of cellular process
1.29 6.59e-04 GO:0051716 cellular response to stimulus
1.47 6.95e-04 GO:0048583 regulation of response to stimulus
1.55 7.84e-04 GO:0009966 regulation of signal transduction
1.41 8.16e-04 GO:0042221 response to chemical stimulus
1.50 8.69e-04 GO:0023051 regulation of signaling
1.32 1.27e-03 GO:0007165 signal transduction
1.66 3.51e-03 GO:0048468 cell development
1.90 6.31e-03 GO:0019226 transmission of nerve impulse
1.90 6.31e-03 GO:0035637 multicellular organismal signaling
1.43 6.85e-03 GO:0007166 cell surface receptor linked signaling pathway
1.48 7.57e-03 GO:0009653 anatomical structure morphogenesis
1.76 8.38e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.22 8.97e-03 GO:0032501 multicellular organismal process
1.19 9.19e-03 GO:0050896 response to stimulus
2.60 1.04e-02 GO:0006936 muscle contraction
1.47 1.21e-02 GO:0007399 nervous system development
2.48 1.82e-02 GO:0003012 muscle system process
1.29 2.22e-02 GO:0048856 anatomical structure development
1.53 4.29e-02 GO:0010646 regulation of cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 3.89e-04 GO:0005737 cytoplasm
1.37 1.62e-03 GO:0044459 plasma membrane part
1.19 1.70e-03 GO:0044444 cytoplasmic part
1.73 4.91e-03 GO:0044431 Golgi apparatus part
1.83 1.89e-02 GO:0043005 neuron projection
1.38 2.16e-02 GO:0012505 endomembrane system
1.74 2.25e-02 GO:0000139 Golgi membrane
1.43 2.69e-02 GO:0005887 integral to plasma membrane
1.42 3.68e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.21 2.22e-02 GO:0005506 iron ion binding
1.50 2.81e-02 GO:0005102 receptor binding