Motif ID: NKX2-1,4.p2

Z-value: 1.419


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_369893330.229.4e-04Click!
NKX2-4chr20_-_213780460.055.1e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_101846668 19.181 GRIK2
glutamate receptor, ionotropic, kainate 2
chr4_-_102268483 16.977 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr17_-_29641087 15.551 EVI2B
ecotropic viral integration site 2B
chr17_-_29641094 13.080 NM_006495
EVI2B
ecotropic viral integration site 2B
chr19_-_40440532 12.589 NM_003890
FCGBP
Fc fragment of IgG binding protein
chrX_+_48542159 11.594 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_-_217724781 11.366 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr20_+_4702499 10.398 NM_012409
PRND
prion protein 2 (dublet)
chr4_+_102734982 10.059 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr22_-_36019363 10.053 NM_203377
MB
myoglobin
chr2_-_89165652 9.783


chr17_-_10452939 9.586 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_-_174320616 9.353 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr5_+_156820161 9.003 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr14_+_39703119 8.976 NM_054024
MIA2
melanoma inhibitory activity 2
chr2_+_28615668 8.586 FOSL2
FOS-like antigen 2
chr17_-_29641068 8.447 EVI2B
ecotropic viral integration site 2B
chr1_+_152850797 8.418 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr15_-_83474805 8.306 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chrX_-_72434656 7.725 NAP1L2
nucleosome assembly protein 1-like 2
chr1_-_144994839 7.687 PDE4DIP
phosphodiesterase 4D interacting protein
chr22_-_29457793 7.591 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr17_+_7623038 7.533 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr2_-_192015751 7.371 STAT4
signal transducer and activator of transcription 4
chr21_-_15918635 7.223 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr11_+_62439134 7.201 C11orf83
chromosome 11 open reading frame 83
chr17_-_7493389 7.173 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr2_+_28615771 7.148 NM_005253
FOSL2
FOS-like antigen 2
chr1_-_59147727 7.090


chr19_-_6670598 7.086 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr14_-_76447445 6.986 TGFB3
transforming growth factor, beta 3
chrX_-_154563735 6.857 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_32716839 6.838 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr8_-_7321028 6.653 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




sperm associated antigen 11B




chr18_-_60986508 6.653 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr11_+_60223281 6.587 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_-_203320249 6.563


chr12_-_53600999 6.479 NM_000889
ITGB7
integrin, beta 7
chr4_+_22694547 6.419 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chrX_-_72434667 6.298 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr17_-_56606710 6.273 NM_004574
SEPT4
septin 4
chr2_+_143886898 6.146 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr7_-_107443631 6.012 NM_000111
SLC26A3
solute carrier family 26, member 3
chrX_+_144908927 5.908 NM_004709
CXorf1
chromosome X open reading frame 1
chr2_-_192015934 5.883 NM_003151
STAT4
signal transducer and activator of transcription 4
chr1_-_203320287 5.829 NM_002023
FMOD
fibromodulin
chr6_+_31949800 5.787 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr5_-_35118223 5.756 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr17_-_34329083 5.720 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr3_+_189349215 5.614 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_-_160492982 5.610 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr5_-_148034089 5.541 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr7_+_129847699 5.481 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr5_-_148016576 5.455 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr4_-_176733413 5.424 GPM6A
glycoprotein M6A
chr8_+_7705401 5.389 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr19_-_55668956 5.285 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr1_-_160681552 5.270 NM_001778
CD48
CD48 molecule
chr3_+_108015392 5.120 HHLA2
HERV-H LTR-associating 2
chr6_+_43266008 5.076 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chrX_-_72434623 5.035 NAP1L2
nucleosome assembly protein 1-like 2
chr12_-_9268513 5.013 A2M
alpha-2-macroglobulin
chr8_-_93115453 4.932 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr2_-_192015733 4.886 STAT4
signal transducer and activator of transcription 4
chr2_-_192016293 4.870 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr3_-_58563070 4.853 FAM107A
family with sequence similarity 107, member A
chr5_+_147443534 4.809 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr14_-_45431121 4.793 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr2_+_143886969 4.760 ARHGAP15
Rho GTPase activating protein 15
chr2_-_100758970 4.738 NM_002285
AFF3
AF4/FMR2 family, member 3
chr12_-_16758312 4.731 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr15_+_74466171 4.724 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr11_-_102826433 4.543 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr10_+_102222797 4.531 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr17_-_56606534 4.449 SEPT4
septin 4
chr1_-_144994908 4.440 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_50451486 4.355 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr21_-_34863779 4.350 NM_017833
DNAJC28
DnaJ (Hsp40) homolog, subfamily C, member 28
chr9_-_77503009 4.326 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr11_-_6643809 4.309 DCHS1
dachsous 1 (Drosophila)
chr2_-_192015706 4.270 STAT4
signal transducer and activator of transcription 4
chr16_+_28943259 4.242 NM_001178098
NM_001770
CD19

CD19 molecule

chr2_+_103035148 4.238 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr12_-_7848324 4.199 NM_020634
GDF3
growth differentiation factor 3
chr20_+_44657858 4.192 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr12_+_41086189 4.158 NM_001843
NM_175038
CNTN1

contactin 1

chr16_-_31100129 4.140 NM_001039503
PRSS53
protease, serine, 53
chr1_-_203198772 4.088 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr10_-_75335415 4.029 NM_152586
USP54
ubiquitin specific peptidase 54
chr7_+_120629444 4.003 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr6_-_11779279 3.982 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chrX_+_64708614 3.954 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chrX_+_49178508 3.952 NM_001098406
GAGE1
GAGE4
GAGE5
GAGE6
GAGE12J
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 12J
chr5_+_140186658 3.941 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr6_+_126240369 3.895 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr11_+_62439120 3.876 NM_001085372
C11orf83
chromosome 11 open reading frame 83
chr12_-_56106061 3.855 NM_001144997
ITGA7
integrin, alpha 7
chr11_+_117947726 3.837 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chrX_+_49363615 3.793 NM_001040663
NM_001468
GAGE1

G antigen 1

chr20_+_31823801 3.792 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr2_+_33701320 3.791 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_46667596 3.741 HOXB3
homeobox B3
chr12_-_53601051 3.648 ITGB7
integrin, beta 7
chr5_+_140800613 3.631 PCDHGA11
protocadherin gamma subfamily A, 11
chrX_+_49160124 3.624 NM_001098413
GAGE10
G antigen 10
chr8_-_57359148 3.610 NM_001135690
PENK
proenkephalin
chr3_-_47621729 3.606 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr8_+_124194751 3.587 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chrX_+_48542193 3.563 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr3_-_187009469 3.447 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr5_-_160279045 3.426 NM_025153
ATP10B
ATPase, class V, type 10B
chr1_-_203320185 3.426 FMOD
fibromodulin
chrX_+_49334991 3.415 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr9_+_124048869 3.392 GSN
gelsolin
chrX_+_49325433 3.389 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr17_-_66951381 3.387 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr5_-_58882274 3.321 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_89591685 3.312 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_155853546 3.303 SYT11
synaptotagmin XI
chr11_-_114466471 3.299 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr11_-_19223516 3.289 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr12_+_25205488 3.271 LRMP
lymphoid-restricted membrane protein
chr12_-_10962673 3.270 NM_023917
TAS2R9
taste receptor, type 2, member 9
chrX_+_54947228 3.269 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr2_+_113816214 3.268 NM_173170
IL36RN
interleukin 36 receptor antagonist
chrX_+_78200828 3.234 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_+_28616360 3.202 FOSL2
FOS-like antigen 2
chr2_+_162272619 3.162 NM_006593
TBR1
T-box, brain, 1
chr8_-_30706532 3.141 NM_031271
TEX15
testis expressed 15
chr1_-_144994943 3.115 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chrX_+_49226137 3.108 NM_001472
NM_001098407
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr3_-_114102488 3.085 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr20_+_44657812 3.083 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_-_226926875 3.068 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr1_+_174417211 3.059 NM_005684
GPR52
G protein-coupled receptor 52
chr10_-_76868853 3.047 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chrX_+_49197555 3.042 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE12J
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 12J
G antigen 2D
G antigen 2A
chr3_+_170077410 3.041 NM_001145097
NM_001248008
SKIL

SKI-like oncogene

chr17_+_67498391 3.006 MAP2K6
mitogen-activated protein kinase kinase 6
chr11_+_118754474 2.997 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr1_-_13452655 2.989 NM_001024661
NM_001099854
PRAMEF13
PRAMEF14
PRAME family member 13
PRAME family member 14
chr16_+_570731 2.930


chr11_+_89764273 2.910 NM_001195234
TRIM49L2
tripartite motif containing 49-like 2
chr20_+_42187705 2.910 SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_1417232 2.861 NM_000547
NM_001206744
NM_001206745
NM_175719
TPO



thyroid peroxidase



chr6_+_73076431 2.854 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr19_+_16830786 2.818 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr21_-_46348633 2.793 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_198608136 2.785 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_158323485 2.762 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr18_-_53068755 2.731 TCF4
transcription factor 4
chr1_+_117297056 2.699 NM_001767
CD2
CD2 molecule
chr7_-_37024664 2.698 NM_001039459
ELMO1
engulfment and cell motility 1
chr11_-_89541742 2.693 NM_020358
TRIM49
tripartite motif containing 49
chr3_-_18480203 2.662 NM_001131010
SATB1
SATB homeobox 1
chr6_-_32160289 2.657 GPSM3
G-protein signaling modulator 3
chr7_+_39017608 2.655 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr19_-_50316360 2.654 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr1_-_25256364 2.645 RUNX3
runt-related transcription factor 3
chr20_+_2276612 2.644 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr3_-_51996855 2.633 NM_033010
PCBP4
poly(rC) binding protein 4
chr7_-_15601574 2.601 NM_001004320
AGMO
alkylglycerol monooxygenase
chrX_+_41583407 2.586 NM_080817
GPR82
G protein-coupled receptor 82
chr17_+_7517263 2.583 SHBG
sex hormone-binding globulin
chr1_-_230849863 2.574 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_-_39270708 2.561 NM_001243093
FYB
FYN binding protein
chr2_+_1418179 2.555 NM_175721
NM_175722
TPO

thyroid peroxidase

chr16_+_72097124 2.543 NM_020995
HPR
haptoglobin-related protein
chr2_+_207406815 2.534 ADAM23
ADAM metallopeptidase domain 23
chr4_-_122302112 2.499 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr11_+_65984213 2.496 PACS1
phosphofurin acidic cluster sorting protein 1
chr15_+_81517639 2.492 NM_172217
IL16
interleukin 16
chr8_-_6914251 2.485 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chrX_-_137821514 2.481 NM_033642
FGF13
fibroblast growth factor 13
chr12_-_87232635 2.478 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chrX_-_40506800 2.474 NM_144970
CXorf38
chromosome X open reading frame 38
chrX_+_49216616 2.473 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr12_-_9268475 2.415 A2M
alpha-2-macroglobulin
chrX_+_49207115 2.401 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr6_+_42018250 2.389 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr4_+_71263598 2.375 NM_021225
PROL1
proline rich, lacrimal 1
chr10_+_70980058 2.375 NM_025130
HKDC1
hexokinase domain containing 1
chr12_+_49688908 2.370 NM_006262
PRPH
peripherin
chr7_+_94539209 2.332 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr3_+_46411632 2.326 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr4_+_72204769 2.296 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chrX_-_54069593 2.272 NM_001184898
PHF8
PHD finger protein 8
chr17_+_7960201 2.243


chr17_-_56406120 2.238 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr17_-_63822660 2.228 NM_001037325
CEP112
centrosomal protein 112kDa
chr19_+_50706868 2.213 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr18_+_6834431 2.211 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr7_-_8302141 2.192 NM_004968
ICA1
islet cell autoantigen 1, 69kDa
chr1_+_152974222 2.191 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr12_-_52886971 2.168 NM_005554
KRT6A
keratin 6A
chr10_+_86131546 2.168 FAM190B
family with sequence similarity 190, member B
chr1_-_9129620 2.160 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_+_170366211 2.154 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr1_-_217250230 2.148 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr10_-_11574273 2.141 NM_001080491
USP6NL
USP6 N-terminal like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.68 1.02e-10 GO:0002376 immune system process
3.00 2.91e-08 GO:0006955 immune response
3.24 2.06e-05 GO:0050776 regulation of immune response
2.68 4.19e-05 GO:0002682 regulation of immune system process
1.38 2.00e-04 GO:0050896 response to stimulus
1.43 2.22e-04 GO:0032501 multicellular organismal process
1.52 6.93e-04 GO:0023052 signaling
1.75 8.00e-04 GO:0065008 regulation of biological quality
2.35 8.49e-04 GO:0006952 defense response
4.09 1.28e-03 GO:0046649 lymphocyte activation
3.67 1.50e-03 GO:0045321 leukocyte activation
1.61 1.63e-03 GO:0048731 system development
1.79 1.68e-03 GO:0048513 organ development
2.74 1.97e-03 GO:0001775 cell activation
5.07 2.24e-03 GO:0042110 T cell activation
2.83 2.49e-03 GO:0002684 positive regulation of immune system process
1.56 2.60e-03 GO:0048856 anatomical structure development
3.55 8.81e-03 GO:0002253 activation of immune response
1.25 1.37e-02 GO:0065007 biological regulation
3.12 1.66e-02 GO:0050778 positive regulation of immune response
1.44 2.22e-02 GO:0032502 developmental process
1.47 2.40e-02 GO:0007275 multicellular organismal development
1.46 3.31e-02 GO:0007165 signal transduction
5.56 4.36e-02 GO:0042113 B cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.17 3.06e-11 GO:0005576 extracellular region
2.87 7.43e-09 GO:0005615 extracellular space
2.57 9.93e-09 GO:0044421 extracellular region part
1.70 2.21e-04 GO:0044459 plasma membrane part
1.92 1.08e-03 GO:0005887 integral to plasma membrane
1.41 1.64e-03 GO:0071944 cell periphery
1.89 1.81e-03 GO:0031226 intrinsic to plasma membrane
1.40 3.69e-03 GO:0005886 plasma membrane
3.23 4.21e-03 GO:0005792 microsome
3.12 6.47e-03 GO:0042598 vesicular fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
29.63 1.06e-03 GO:0030492 hemoglobin binding
4.04 2.83e-03 GO:0030414 peptidase inhibitor activity
3.92 4.09e-03 GO:0008083 growth factor activity
22.22 4.78e-03 GO:0019864 IgG binding
3.96 7.35e-03 GO:0004866 endopeptidase inhibitor activity
3.80 1.12e-02 GO:0061135 endopeptidase regulator activity
3.38 2.07e-02 GO:0061134 peptidase regulator activity
1.87 2.92e-02 GO:0005102 receptor binding
1.90 3.18e-02 GO:0030234 enzyme regulator activity
3.21 3.65e-02 GO:0005125 cytokine activity
2.78 4.19e-02 GO:0004857 enzyme inhibitor activity