Motif ID: NR1H4.p2

Z-value: 2.493


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR1H4chr12_+_1008971370.558.4e-19Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_21945031 49.643 NM_032846
RAB2B
RAB2B, member RAS oncogene family
chr9_+_74526527 41.062 C9orf85
chromosome 9 open reading frame 85
chr5_-_149792276 39.337 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_+_152635871 38.373 NM_178430
LCE2D
late cornified envelope 2D
chr14_-_106111114 38.072 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr17_+_1665233 37.482 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665306 36.685 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665281 36.198 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_106092256 35.534 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr17_+_1665342 34.868 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_+_55464605 34.801 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr3_-_49158357 31.317 NM_001199160
NM_001199161
NM_001199162
NM_006677
USP19



ubiquitin specific peptidase 19



chr20_-_44455932 30.912 NM_003279
TNNC2
troponin C type 2 (fast)
chr5_-_139943829 30.647 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr14_-_106237675 28.895 IGHM
immunoglobulin heavy constant mu
chr3_-_49158171 28.677 USP19
ubiquitin specific peptidase 19
chr19_+_35629727 28.664 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr16_+_69166538 28.231 CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr11_+_45868956 27.564 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr5_-_139944045 27.245 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr12_+_58013692 26.045 NM_133489
SLC26A10
solute carrier family 26, member 10
chr3_-_49158256 23.151 USP19
ubiquitin specific peptidase 19
chr20_+_30639981 22.397 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr1_+_152647770 22.156 NM_178429
LCE2C
late cornified envelope 2C
chrX_+_128913881 22.019 NM_018990
SASH3
SAM and SH3 domain containing 3
chr11_-_64511550 21.988 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr6_-_32908583 21.303 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_-_74374998 21.098 NM_001035505
NM_212552
BOLA3

bolA homolog 3 (E. coli)

chrX_+_103031433 21.086 NM_001128834
PLP1
proteolipid protein 1
chrX_+_103031797 20.600 PLP1
proteolipid protein 1
chr17_+_79651052 20.411


chr5_+_79330990 19.863 NM_003248
THBS4
thrombospondin 4
chr1_+_36689996 19.059 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr3_+_14989076 19.041 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr8_-_125740378 18.492 MTSS1
metastasis suppressor 1
chr3_+_52489617 18.045 NISCH
nischarin
chr8_-_57359148 18.032 NM_001135690
PENK
proenkephalin
chr3_+_111261039 17.631 CD96
CD96 molecule
chrX_+_103031753 17.555 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr22_+_22569155 17.479


chr11_+_119077021 17.343 CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr6_-_49681245 17.129 NM_001142407
NM_001142408
NM_001142417
NM_001142435
NM_003296
CRISP2




cysteine-rich secretory protein 2




chr3_-_57113292 16.592 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr22_-_36019363 16.527 NM_203377
MB
myoglobin
chr1_+_36690038 16.465 THRAP3
thyroid hormone receptor associated protein 3
chr17_-_62207475 16.361 NM_001433
ERN1
endoplasmic reticulum to nucleus signaling 1
chr19_+_50706868 16.300 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr17_-_26879645 16.233 NM_005148
NM_054035
UNC119

unc-119 homolog (C. elegans)

chr3_-_28390506 16.139 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr11_-_7041465 16.062 NM_013249
ZNF214
zinc finger protein 214
chr10_-_95360959 16.011 NM_006744
RBP4
retinol binding protein 4, plasma
chr11_-_64510339 15.942 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr22_-_20104695 15.922 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr19_-_39390168 15.905 NM_012237
NM_001193286
NM_030593
SIRT2


sirtuin 2


chr7_-_37488554 15.828 NM_014800
ELMO1
engulfment and cell motility 1
chr3_+_52489646 15.626 NISCH
nischarin
chr9_+_74526369 15.560 NM_182505
C9orf85
chromosome 9 open reading frame 85
chr3_-_28390280 15.435 AZI2
5-azacytidine induced 2
chr17_-_26879577 15.122 UNC119
unc-119 homolog (C. elegans)
chr12_-_57914287 14.948 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr11_-_5275904 14.732 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr5_+_149569519 14.512 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr11_+_45868668 14.386 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr3_+_183873305 14.362 DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr12_+_109273856 14.328 NM_001917
DAO
D-amino-acid oxidase
chr6_-_109415514 14.324 NM_014454
SESN1
sestrin 1
chrX_-_70288155 14.160 NM_013346
SNX12
sorting nexin 12
chr5_+_79783799 14.139 NM_205548
FAM151B
family with sequence similarity 151, member B
chr3_-_50383009 14.045 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chr3_-_196014519 13.996 PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr19_-_48867149 13.944 NM_018273
TMEM143
transmembrane protein 143
chr3_-_195306274 13.941 APOD
apolipoprotein D
chr7_-_37488408 13.892 ELMO1
engulfment and cell motility 1
chr16_+_30418885 13.804 ZNF771
zinc finger protein 771
chr2_-_182545212 13.769 NM_002500
CERKL
NEUROD1
ceramide kinase-like
neurogenic differentiation 1
chr22_+_32149936 13.687 NM_001242897
DEPDC5
DEP domain containing 5
chr3_+_9404706 13.683 NM_001114092
NM_015453
THUMPD3

THUMP domain containing 3

chr3_+_122296432 13.681 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr6_+_31554975 13.676 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr17_+_73975297 13.643 NM_001113324
TEN1
TEN1-CDK3
TEN1 telomerase capping complex subunit homolog (S. cerevisiae)
TEN1-CDK3 readthrough
chr9_-_74526107 13.626 NM_001025780
NM_016014
FAM108B1

family with sequence similarity 108, member B1

chr5_-_33891967 13.621 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr15_+_74908195 13.607 CLK3
CDC-like kinase 3
chr17_+_64298731 13.601 PRKCA
protein kinase C, alpha
chr4_-_71532341 13.521 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr11_-_72353435 13.510 NM_001143839
NM_001243784
PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr11_+_67250504 13.467 NM_003977
AIP
aryl hydrocarbon receptor interacting protein
chr22_-_29711474 13.338 RASL10A
RAS-like, family 10, member A
chr12_+_100661203 13.333 NM_017988
SCYL2
SCY1-like 2 (S. cerevisiae)
chr5_+_140588267 13.326 NM_018932
PCDHB12
protocadherin beta 12
chr1_+_202317798 13.273 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr14_-_93799360 13.249 BTBD7
BTB (POZ) domain containing 7
chr22_+_31090792 13.161 NM_030758
OSBP2
oxysterol binding protein 2
chr12_+_100661158 13.115 SCYL2
SCY1-like 2 (S. cerevisiae)
chr3_+_52489503 13.088 NM_007184
NISCH
nischarin
chr14_-_93799371 12.987 NM_001002860
NM_018167
BTBD7

BTB (POZ) domain containing 7

chr3_+_186560462 12.862 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr1_+_32716839 12.861 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr19_+_859658 12.754 NM_001928
CFD
complement factor D (adipsin)
chr2_-_73869493 12.740 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr3_+_133465250 12.716 TF
transferrin
chrX_+_18443702 12.715 NM_003159
CDKL5
cyclin-dependent kinase-like 5
chr15_-_72668184 12.690 HEXA
hexosaminidase A (alpha polypeptide)
chr12_+_69742140 12.655 LYZ
lysozyme
chr22_+_22712091 12.571 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr3_-_14988976 12.545 LOC100505641
uncharacterized LOC100505641
chr10_+_106034886 12.447 NM_001191014
NM_001191015
GSTO2

glutathione S-transferase omega 2

chr3_-_50340979 12.430 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chrX_-_78622711 12.399 ITM2A
integral membrane protein 2A
chr11_-_68518910 12.386 MTL5
metallothionein-like 5, testis-specific (tesmin)
chr6_+_127587984 12.367 RNF146
ring finger protein 146
chr16_+_30194925 12.283 CORO1A
coronin, actin binding protein, 1A
chr22_-_29711650 12.204 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr22_-_20104745 12.169 NM_022727
NM_182984
TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

chr11_-_118123001 12.147 NM_198275
MPZL3
myelin protein zero-like 3
chr11_+_128563772 12.110 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr6_-_32160289 12.082 GPSM3
G-protein signaling modulator 3
chr11_+_63993720 12.009 NM_001128612
NM_001128613
NM_032344
NUDT22


nudix (nucleoside diphosphate linked moiety X)-type motif 22


chr3_+_183873215 11.885 DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr19_+_39390570 11.836 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr4_-_176733413 11.832 GPM6A
glycoprotein M6A
chr12_+_6898705 11.740 CD4
CD4 molecule
chr3_+_130745693 11.738 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr1_-_182354649 11.645 GLUL
glutamate-ammonia ligase
chr1_+_15764934 11.589 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr11_+_117857123 11.578 IL10RA
interleukin 10 receptor, alpha
chr3_-_38071030 11.558 NM_006225
PLCD1
phospholipase C, delta 1
chr4_+_54243731 11.508 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr17_-_73975443 11.447 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr22_-_23974486 11.433 NM_016449
C22orf43
chromosome 22 open reading frame 43
chr11_+_67250595 11.415 AIP
aryl hydrocarbon receptor interacting protein
chr16_+_30194730 11.324 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr3_-_14988939 11.304 LOC100505641
uncharacterized LOC100505641
chr22_+_24999113 11.303 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr3_-_187452669 11.278 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr16_+_23847321 11.209 PRKCB
protein kinase C, beta
chr7_+_154862545 11.182 NM_024012
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A
chr3_+_183873309 11.157 DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr19_+_859673 11.062 CFD
complement factor D (adipsin)
chr11_+_119076974 11.047 NM_005188
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr15_-_34212523 10.977


chr11_+_63304272 10.975 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr1_+_152658598 10.941 NM_014357
LCE2B
late cornified envelope 2B
chr11_+_62380212 10.937 NM_000327
ROM1
retinal outer segment membrane protein 1
chr7_-_44198873 10.844 NM_033507
NM_033508
GCK

glucokinase (hexokinase 4)

chr5_-_33892292 10.814 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr12_+_6898605 10.800 NM_000616
NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4




CD4 molecule




chr22_+_32150002 10.786 NM_001007188
NM_001242896
NM_014662
DEPDC5


DEP domain containing 5


chr1_+_44412582 10.762 IPO13
importin 13
chr3_-_14989399 10.634 LOC100505641
uncharacterized LOC100505641
chr14_+_99947732 10.573 NM_001099402
CCNK
cyclin K
chr15_+_40698000 10.497 IVD
isovaleryl-CoA dehydrogenase
chr19_+_10197023 10.419 C19orf66
chromosome 19 open reading frame 66
chr4_+_54243810 10.364 NM_001134937
NM_001134938
NM_030917
FIP1L1


FIP1 like 1 (S. cerevisiae)


chrX_-_65835845 10.336 NM_001242310
EDA2R
ectodysplasin A2 receptor
chr14_-_25103365 10.317 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr22_+_19705990 10.311 SEPT5-GP1BB
SEPT5-GP1BB readthrough
chr3_+_133464883 10.271 NM_001063
TF
transferrin
chr3_+_133465098 10.240 TF
transferrin
chr16_+_58534045 10.238 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr3_+_133465204 10.212 TF
transferrin
chr6_+_30594607 10.160 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr16_+_89238160 10.144 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr14_-_75078669 10.116 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr19_-_633474 10.074 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr6_+_127587826 10.034 NM_001242851
NM_001242844
NM_001242849
NM_001242852
NM_001242845
NM_001242846
NM_001242850
NM_030963
RNF146







ring finger protein 146







chr19_-_42746678 10.003 GSK3A
glycogen synthase kinase 3 alpha
chr4_+_54243822 10.002 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr3_-_130745583 9.970 NM_014065
ASTE1
asteroid homolog 1 (Drosophila)
chr19_+_589849 9.950 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr8_-_27101240 9.909 STMN4
stathmin-like 4
chr11_+_71639767 9.871 NM_018320
RNF121
ring finger protein 121
chr17_-_73257703 9.853 NM_014001
NM_138619
GGA3

golgi-associated, gamma adaptin ear containing, ARF binding protein 3

chr11_-_71781091 9.835 NUMA1
nuclear mitotic apparatus protein 1
chr3_+_101546833 9.829 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chrX_-_49965003 9.810 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr3_+_111260925 9.776 NM_005816
NM_198196
CD96

CD96 molecule

chr19_+_10196972 9.746 C19orf66
chromosome 19 open reading frame 66
chr22_+_32149962 9.621 DEPDC5
DEP domain containing 5
chr5_+_161274196 9.582 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr8_-_70983468 9.573 PRDM14
PR domain containing 14
chr12_+_106696508 9.478 NM_152772
TCP11L2
t-complex 11 (mouse)-like 2
chr22_+_23134980 9.473


chr18_-_51750460 9.473 MBD2
methyl-CpG binding domain protein 2
chr16_+_23847359 9.416 PRKCB
protein kinase C, beta
chr4_+_54243829 9.365 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr10_-_90750955 9.297 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr22_+_19705891 9.267 NM_001009939
SEPT5
septin 5
chr17_-_44895962 9.220 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr17_-_37764165 9.181 NM_006160
NEUROD2
neurogenic differentiation 2
chr17_-_33905556 9.181 NM_000286
PEX12
peroxisomal biogenesis factor 12
chr17_+_40913211 9.116 NM_005854
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr3_-_196014583 9.108 NM_005017
PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr19_-_56348127 9.087 NM_145007
NLRP11
NLR family, pyrin domain containing 11
chr17_+_59529778 9.013 TBX4
T-box 4
chr1_+_32739711 8.896 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr11_+_1874199 8.871 NM_002339
LSP1
lymphocyte-specific protein 1
chr22_+_30792929 8.801 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr4_-_46911223 8.731 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr14_+_85999464 8.666



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.27e-09 GO:0065007 biological regulation
1.22 2.76e-07 GO:0050789 regulation of biological process
1.34 3.57e-06 GO:0023052 signaling
1.23 3.44e-05 GO:0050896 response to stimulus
1.34 7.25e-05 GO:0007165 signal transduction
1.20 1.01e-04 GO:0050794 regulation of cellular process
1.29 1.11e-04 GO:0051716 cellular response to stimulus
2.18 1.80e-03 GO:0034097 response to cytokine stimulus
2.47 2.15e-03 GO:0003013 circulatory system process
2.47 2.15e-03 GO:0008015 blood circulation
1.38 3.93e-03 GO:0065008 regulation of biological quality
1.60 5.05e-03 GO:0042127 regulation of cell proliferation
1.10 1.13e-02 GO:0009987 cellular process
1.39 1.23e-02 GO:0048583 regulation of response to stimulus
1.39 2.20e-02 GO:0007166 cell surface receptor linked signaling pathway
1.34 2.46e-02 GO:0042221 response to chemical stimulus
2.91 3.33e-02 GO:0007586 digestion
2.21 3.72e-02 GO:0071345 cellular response to cytokine stimulus
1.54 4.88e-02 GO:0070887 cellular response to chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 2.52e-06 GO:0044459 plasma membrane part
1.61 6.78e-06 GO:0005887 integral to plasma membrane
1.58 2.14e-05 GO:0031226 intrinsic to plasma membrane
1.36 2.63e-03 GO:0005576 extracellular region
1.60 3.63e-03 GO:0005615 extracellular space
1.47 1.77e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.13 4.04e-05 GO:0003823 antigen binding
1.99 2.50e-02 GO:0032403 protein complex binding
1.74 4.02e-02 GO:0008289 lipid binding