Motif ID: NR3C1.p2

Z-value: 1.614


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR3C1chr5_-_142783059-0.291.4e-05Click!


Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_91572328 24.933 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr21_-_46340776 22.777 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr11_+_73358593 22.081 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr21_-_46340821 22.046 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr7_+_23286390 21.590 GPNMB
glycoprotein (transmembrane) nmb
chr22_+_22712091 20.863 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr7_+_23286386 20.799 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286384 20.616 GPNMB
glycoprotein (transmembrane) nmb
chr3_-_187463227 20.574 BCL6
B-cell CLL/lymphoma 6
chr2_-_237172987 19.131 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr7_+_20655244 18.844 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr19_-_36643770 18.811 NM_001864
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr10_+_70847817 17.450 NM_002727
SRGN
serglycin
chr7_-_124405029 15.140 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr8_-_110655418 14.435 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr17_-_8055684 13.099 NM_002616
PER1
period homolog 1 (Drosophila)
chr6_-_6320875 12.916 F13A1
coagulation factor XIII, A1 polypeptide
chr1_+_44115804 12.884 KDM4A
lysine (K)-specific demethylase 4A
chrY_+_16168097 12.744 NM_181880
NM_004679
VCY1B
VCX3A
VCY
variable charge, Y-linked 1B
variable charge, X-linked 3A
variable charge, Y-linked
chr19_+_15783827 12.527 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_-_153085963 12.189 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr6_-_6320897 12.130 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr18_-_53068755 11.781 TCF4
transcription factor 4
chr16_-_68482373 11.739 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr6_-_32191779 11.550 NM_004557
NOTCH4
notch 4
chr1_-_204459445 11.450 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr7_-_37393271 11.333 NM_001206482
ELMO1
engulfment and cell motility 1
chr1_+_20964414 11.281


chr12_-_123466195 11.256 ABCB9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr1_+_44115828 11.103 KDM4A
lysine (K)-specific demethylase 4A
chr5_+_180467224 10.978 NM_152547
BTNL9
butyrophilin-like 9
chr5_-_42811959 10.809 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr19_+_39899749 10.650


chr10_+_121578768 10.368 NM_001243194
INPP5F
inositol polyphosphate-5-phosphatase F
chr1_-_160492982 10.272 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chrX_+_128913897 10.125 SASH3
SAM and SH3 domain containing 3
chr15_-_45670955 10.009 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chrX_+_128913881 9.996 NM_018990
SASH3
SAM and SH3 domain containing 3
chr2_+_113816214 9.908 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr7_+_23286277 9.861 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr2_-_89292396 9.808 IGKC
immunoglobulin kappa constant
chr7_+_105603656 9.731 NM_152750
CDHR3
cadherin-related family member 3
chr7_+_87563432 9.678 NM_004194
NM_016351
NM_021721
NM_021722
NM_021723
ADAM22




ADAM metallopeptidase domain 22




chr7_+_23286401 9.432 GPNMB
glycoprotein (transmembrane) nmb
chr17_-_26903854 9.228 ALDOC
aldolase C, fructose-bisphosphate
chr16_+_30386097 9.219 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr1_+_22979681 9.177 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr1_+_158223926 9.161 NM_001763
CD1A
CD1a molecule
chr16_+_8814567 8.877 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr15_-_34212523 8.827


chr11_+_60048013 8.666 NM_001243266
NM_024021
NM_148975
MS4A4A


membrane-spanning 4-domains, subfamily A, member 4


chr2_-_85895863 8.533 NM_000542
NM_198843
SFTPB

surfactant protein B

chr17_+_37824506 8.501 NM_002686
PNMT
phenylethanolamine N-methyltransferase
chr6_-_108145507 8.150 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr2_+_31456879 7.987 NM_014600
EHD3
EH-domain containing 3
chr14_+_24616707 7.962 RNF31
ring finger protein 31
chr6_+_134210247 7.871 NM_198392
NM_003206
TCF21

transcription factor 21

chr17_-_70588942 7.779 LOC100499467
uncharacterized LOC100499467
chr1_-_161279724 7.669 NM_000530
MPZ
myelin protein zero
chr10_-_5541401 7.624 NM_017422
CALML5
calmodulin-like 5
chr14_+_24616658 7.581 NM_017999
RNF31
ring finger protein 31
chr3_+_133495925 7.580 TF
transferrin
chr12_+_7055736 7.578 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_-_52628272 7.490 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr16_-_4852571 7.485 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr17_-_46115135 7.347 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr18_-_24442534 7.287 NM_004028
AQP4
aquaporin 4
chr11_-_36619776 7.279 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr6_+_134210264 7.246 TCF21
transcription factor 21
chr3_+_45067750 7.190 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr12_+_51318515 7.148 NM_014033
METTL7A
methyltransferase like 7A
chr4_+_72204769 7.117 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr3_-_49314281 7.032 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr8_+_103563847 6.999 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr16_-_21314371 6.851 NM_001014444
NM_001888
CRYM

crystallin, mu

chr12_+_51318743 6.849 METTL7A
methyltransferase like 7A
chr16_-_20702577 6.808 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr5_-_149669187 6.790 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr1_-_147232684 6.780 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr1_+_209859524 6.691 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr9_-_90749899 6.643 NM_001166137
FAM75C2
family with sequence similarity 75, member C2
chr8_-_30891230 6.605 NM_001015508
PURG
purine-rich element binding protein G
chr1_+_162602308 6.586 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_-_153363544 6.509 NM_002964
S100A8
S100 calcium binding protein A8
chr8_-_120651019 6.269 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr8_-_110657745 6.143 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr1_+_33004771 6.132 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr14_+_70918873 6.080 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chrX_+_46940235 6.066 RGN
regucalcin (senescence marker protein-30)
chr14_-_107131217 5.987 IGHA1
immunoglobulin heavy constant alpha 1
chr7_+_94539209 5.952 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr17_-_26903926 5.936 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr16_-_5115939 5.913 C16orf89
chromosome 16 open reading frame 89
chr3_-_187452669 5.861 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr12_+_7055753 5.763 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr7_+_123565908 5.752 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr6_+_150690027 5.716 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr1_+_13495253 5.639 NM_001045480
PRAMEF17
PRAMEF16
PRAME family member 17
PRAME family member 16
chr15_+_75105152 5.635 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr1_-_182922504 5.618 NM_030933
SHCBP1L
SHC SH2-domain binding protein 1-like
chr8_+_1952875 5.541 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr14_-_106774311 5.540 IGHA1
immunoglobulin heavy constant alpha 1
chr21_+_41239346 5.469 NM_006198
PCP4
Purkinje cell protein 4
chr6_-_52668599 5.445 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr7_+_123565285 5.412 NM_001174044
NM_003117
NM_153189
SPAM1


sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)


chr6_+_26156552 5.355 HIST1H1E
histone cluster 1, H1e
chr1_+_35225341 5.177 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr1_-_59147727 5.135


chrX_+_18709044 5.078 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr6_-_99873129 5.062 NM_015491
NM_032870
PNISR

PNN-interacting serine/arginine-rich protein

chr9_-_77503009 5.060 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr10_-_123353330 4.945 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr22_+_45704821 4.893 NM_001104595
FAM118A
family with sequence similarity 118, member A
chr9_+_102677457 4.876 STX17
syntaxin 17
chr15_+_42694587 4.870 NM_173088
CAPN3
calpain 3, (p94)
chr4_+_86699846 4.792 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr8_-_146202727 4.755 ZNF252
zinc finger protein 252
chr8_-_53322200 4.623 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr1_+_173793817 4.597 DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr14_-_106746056 4.566


chr2_+_113342171 4.530 CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr11_+_118175294 4.511 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr22_+_22676814 4.472


chr2_-_43453724 4.462 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr15_-_43029318 4.431 NM_138477
CDAN1
congenital dyserythropoietic anemia, type I
chr10_-_47173917 4.374 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr22_+_23040394 4.332 IGL@
immunoglobulin lambda locus
chr4_+_113970784 4.302 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr1_+_43766565 4.288 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr8_-_127570465 4.281 FAM84B
family with sequence similarity 84, member B
chr9_+_90532876 4.279 NM_001145124
FAM75C1
family with sequence similarity 75, member C1
chr9_-_73029539 4.267 NM_001206
KLF9
Kruppel-like factor 9
chr2_-_202563353 4.266 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr17_-_43487747 4.235 ARHGAP27
Rho GTPase activating protein 27
chr5_+_35856990 4.186 NM_002185
IL7R
interleukin 7 receptor
chr17_+_7387773 4.124 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr16_-_31100129 4.123 NM_001039503
PRSS53
protease, serine, 53
chr16_+_3451154 4.119 NM_001032292
NM_003450
ZNF174

zinc finger protein 174

chr1_-_11188800 4.118


chr16_+_90089007 4.116 NM_001481
GAS8
growth arrest-specific 8
chr11_-_118123001 4.105 NM_198275
MPZL3
myelin protein zero-like 3
chr13_+_96204941 4.094 NM_006984
CLDN10
claudin 10
chr12_-_54121203 4.052 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr6_-_49844808 4.039 NM_001205220
CRISP1
cysteine-rich secretory protein 1
chr22_+_37678565 4.026 CYTH4
cytohesin 4
chr1_-_151319674 4.000 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr22_+_37678519 3.986 CYTH4
cytohesin 4
chr6_-_32908583 3.977 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr16_+_31366519 3.959 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_+_111770280 3.905 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr2_-_68384575 3.895 NM_138458
WDR92
WD repeat domain 92
chr10_-_123353771 3.852 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr5_-_147162251 3.847 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chrX_-_135749436 3.809 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr12_-_16758312 3.796 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_-_139943829 3.782 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr6_+_26156558 3.745 NM_005321
HIST1H1E
histone cluster 1, H1e
chr7_+_99621083 3.744 ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr2_-_214016332 3.691 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr19_+_55014012 3.685 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr12_+_69742130 3.673 NM_000239
LYZ
lysozyme
chr1_-_111743261 3.652 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr14_+_23067128 3.593 NM_022060
ABHD4
abhydrolase domain containing 4
chr5_-_149324282 3.564 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr9_-_21202201 3.535 NM_021057
IFNA7
interferon, alpha 7
chr3_-_146213721 3.531 NM_001199979
PLSCR2
phospholipid scramblase 2
chrX_+_65382627 3.511 HEPH
hephaestin
chr5_+_137203559 3.496 MYOT
myotilin
chr19_+_58570606 3.452 NM_001164527
NM_001164529
NM_001164530
NM_003436
NM_007134
ZNF135




zinc finger protein 135




chr19_+_54926721 3.412 TTYH1
tweety homolog 1 (Drosophila)
chr6_-_134496833 3.371 SGK1
serum/glucocorticoid regulated kinase 1
chr17_-_62009620 3.356 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr1_+_159173802 3.349 NM_002036
DARC
Duffy blood group, chemokine receptor
chr17_-_29641094 3.317 NM_006495
EVI2B
ecotropic viral integration site 2B
chr1_+_89829435 3.276 NM_198460
GBP6
guanylate binding protein family, member 6
chr7_-_124405680 3.244 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr10_+_102672685 3.233 FAM178A
family with sequence similarity 178, member A
chr17_+_77751929 3.218 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr16_-_20338808 3.195 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr4_-_76823575 3.193 NM_006239
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr9_+_131388167 3.179 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr3_-_194090459 3.174 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr11_-_59633942 3.169 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr1_-_111743297 3.169 DENND2D
DENN/MADD domain containing 2D
chr17_+_11786218 3.123 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr12_+_50898744 3.086 NM_173602
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr4_-_95263986 3.078 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr11_-_118047145 3.062 SCN2B
sodium channel, voltage-gated, type II, beta
chrX_+_48114796 3.049 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr3_+_155838336 3.030 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr17_+_21308447 2.961 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chrX_-_100548044 2.960 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr14_-_45722604 2.943 NM_018353
MIS18BP1
MIS18 binding protein 1
chr12_-_16757944 2.922 LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_+_50472856 2.907 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr6_-_89927495 2.906 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr1_+_162602198 2.865 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr17_+_7960201 2.840


chr3_+_35722428 2.822 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr17_-_8815799 2.815 NM_014308
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.27 5.70e-08 GO:0002376 immune system process
2.52 3.32e-06 GO:0006955 immune response
2.07 2.02e-03 GO:0009611 response to wounding
2.47 3.66e-03 GO:0001775 cell activation
2.09 4.44e-03 GO:0006952 defense response
2.47 1.07e-02 GO:0050776 regulation of immune response
1.28 1.25e-02 GO:0050896 response to stimulus
2.77 3.70e-02 GO:0006954 inflammatory response
2.16 3.94e-02 GO:0042060 wound healing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 6.94e-06 GO:0071944 cell periphery
1.47 7.72e-06 GO:0005886 plasma membrane
2.02 2.01e-03 GO:0005615 extracellular space
1.75 3.63e-03 GO:0031226 intrinsic to plasma membrane
1.76 4.11e-03 GO:0005887 integral to plasma membrane
1.53 4.97e-03 GO:0044459 plasma membrane part
1.81 7.43e-03 GO:0044421 extracellular region part
1.49 3.20e-02 GO:0005576 extracellular region
3.30 3.64e-02 GO:0009897 external side of plasma membrane
1.19 3.73e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.89 4.86e-04 GO:0003823 antigen binding