Motif ID: NR5A1,2.p2

Z-value: 2.191


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR5A2chr1_+_1999967290.313.3e-06Click!
NR5A1chr9_-_1272696890.188.8e-03Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_55464605 32.193 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr11_-_5275904 27.279 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr11_-_5271035 27.168 NM_000559
HBG1
hemoglobin, gamma A
chr10_-_101190201 26.008 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr22_+_41865112 23.866 NM_001098
ACO2
aconitase 2, mitochondrial
chrX_+_103031433 23.819 NM_001128834
PLP1
proteolipid protein 1
chrX_+_103031797 23.555 PLP1
proteolipid protein 1
chrX_+_103031753 21.437 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr12_-_120554558 20.871 RAB35
RAB35, member RAS oncogene family
chr12_-_9268440 19.637 A2M
alpha-2-macroglobulin
chr12_-_9268522 19.417 NM_000014
A2M
alpha-2-macroglobulin
chr6_-_108145507 18.706 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr12_-_9268513 18.669 A2M
alpha-2-macroglobulin
chr2_-_218843541 18.363 TNS1
tensin 1
chr14_+_93389491 17.745 CHGA
chromogranin A (parathyroid secretory protein 1)
chr5_-_42811959 17.507 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr17_-_48271968 16.967


chr5_-_11904127 16.271 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr2_+_98262497 15.395 NM_001862
COX5B
cytochrome c oxidase subunit Vb
chr3_+_133464883 14.635 NM_001063
TF
transferrin
chr16_+_226678 14.491 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr12_-_9268475 14.336 A2M
alpha-2-macroglobulin
chr14_-_103989195 14.295 NM_001823
CKB
creatine kinase, brain
chr14_-_103989112 14.133 CKB
creatine kinase, brain
chr1_-_182354649 13.690 GLUL
glutamate-ammonia ligase
chr3_+_133465250 13.630 TF
transferrin
chr3_+_133465098 13.594 TF
transferrin
chr5_+_80529138 13.546 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr5_-_11903964 13.479 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr12_-_106532447 13.445 NUAK1
NUAK family, SNF1-like kinase, 1
chrX_-_13835187 13.225 GPM6B
glycoprotein M6B
chr11_-_5248180 13.124 NM_000518
HBB
hemoglobin, beta
chr3_+_133465204 13.072 TF
transferrin
chr12_+_119616594 12.214 NM_014365
HSPB8
heat shock 22kDa protein 8
chr19_-_36643770 12.156 NM_001864
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr14_-_103988829 12.017 CKB
creatine kinase, brain
chr14_-_106174914 11.738 IGHA1
immunoglobulin heavy constant alpha 1
chr2_-_175869910 11.652 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr15_+_91769329 11.500 SV2B
synaptic vesicle glycoprotein 2B
chrX_-_13835012 11.475 GPM6B
glycoprotein M6B
chr18_-_74728963 11.410 MBP
myelin basic protein
chr12_+_48516428 11.302 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr19_-_57336373 11.277 NM_001146186
PEG3
paternally expressed 3
chr18_-_74729049 11.172 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr17_-_48271365 11.044


chr17_-_26903854 10.653 ALDOC
aldolase C, fructose-bisphosphate
chr22_-_19511777 10.541 CLDN5
claudin 5
chr12_-_11463353 10.465 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr12_-_120554551 10.218 RAB35
RAB35, member RAS oncogene family
chr21_-_27107184 10.072 ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr22_-_44258210 10.028 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr19_-_45826131 9.826 CKM
creatine kinase, muscle
chr8_-_120651019 9.535 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr3_-_47957475 9.517


chr8_-_22089517 9.462 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr20_-_32031425 9.410 NM_003098
SNTA1
syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
chr12_-_120554453 9.398 RAB35
RAB35, member RAS oncogene family
chr6_+_30856462 9.361 NM_001202521
NM_001202522
NM_013994
DDR1


discoidin domain receptor tyrosine kinase 1


chr8_+_136469557 9.333 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr14_+_93389444 9.325 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr12_-_122296619 9.306 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr6_-_46293628 9.267 NM_005822
RCAN2
regulator of calcineurin 2
chr11_+_73359734 9.057 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr12_-_11002051 9.050 NM_001098538
NM_007244
PRR4

proline rich 4 (lacrimal)

chrX_-_107225588 8.923 NM_031273
TEX13B
testis expressed 13B
chr22_+_23040394 8.906 IGL@
immunoglobulin lambda locus
chr7_-_44105162 8.689 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr16_+_56623266 8.579 NM_005954
MT3
metallothionein 3
chr16_+_2587989 8.571 PDPK1
3-phosphoinositide dependent protein kinase-1
chr3_-_52312257 8.492 WDR82
WD repeat domain 82
chr16_+_2588000 8.481 PDPK1
3-phosphoinositide dependent protein kinase-1
chr12_-_111358353 8.439 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr1_+_2036154 8.372 NM_001033582
PRKCZ
protein kinase C, zeta
chr11_-_790103 8.254 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr3_-_123339423 8.249 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr17_-_26903926 8.225 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr1_+_236849753 8.217 NM_001103
ACTN2
actinin, alpha 2
chr10_+_88428167 8.079 NM_001171610
LDB3
LIM domain binding 3
chr12_+_109577201 7.938 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr20_-_62130390 7.908 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr3_-_50605062 7.901 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr11_-_66639602 7.898


chr16_+_2588021 7.820 PDPK1
3-phosphoinositide dependent protein kinase-1
chr22_+_23222897 7.807 CYAT1
immunoglobulin lambda light chain-like
chr11_-_62472901 7.798


chr17_-_8066254 7.789 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chrX_+_70443055 7.779 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr8_-_110657025 7.755 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr17_+_26800657 7.724 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr3_-_123339178 7.716 MYLK
myosin light chain kinase
chr12_-_11422640 7.612 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr22_-_36019363 7.595 NM_203377
MB
myoglobin
chr6_+_27775898 7.591 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr16_+_57481336 7.588 NM_020312
COQ9
coenzyme Q9 homolog (S. cerevisiae)
chr5_+_161274196 7.569 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_56618178 7.538 NM_001198713
SEPT4
septin 4
chr3_+_50306578 7.520 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr17_+_7608413 7.516 NM_001406
EFNB3
ephrin-B3
chr4_-_57522469 7.338 NM_001145459
NM_139211
HOPX

HOP homeobox

chr2_+_220492286 7.314 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr22_-_39240016 7.272 NM_014293
NPTXR
neuronal pentraxin receptor
chr14_-_106237486 7.194


chr22_-_29711650 7.192 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr14_-_107013474 7.185 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_-_29711474 7.176 RASL10A
RAS-like, family 10, member A
chr5_+_140868721 7.152 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr17_-_73505914 7.141 NM_001142643
CASKIN2
CASK interacting protein 2
chr3_+_52813936 7.128 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr3_+_49027281 7.125 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr8_+_86376130 7.122 NM_000067
CA2
carbonic anhydrase II
chr7_-_124405680 7.072 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_1260289 7.059


chr12_-_16759531 7.045 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_+_19626535 6.968 NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr2_-_242556883 6.943 NM_001164356
THAP4
THAP domain containing 4
chr4_-_88450243 6.939 SPARCL1
SPARC-like 1 (hevin)
chr4_+_30722191 6.935 PCDH7
protocadherin 7
chr16_-_4852571 6.906 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr19_+_45449228 6.887 NM_000483
APOC2
apolipoprotein C-II
chr5_-_134914968 6.845 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr1_-_171621750 6.837 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr9_+_126773851 6.826 NM_004789
LHX2
LIM homeobox 2
chr10_+_105036783 6.823 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr20_-_23669606 6.818 NM_001899
CST4
cystatin S
chr6_-_27782517 6.775 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr6_+_27100784 6.765 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr1_+_19923457 6.723 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr2_-_179672056 6.708 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr20_-_48532036 6.686 SPATA2
spermatogenesis associated 2
chr22_+_30792929 6.657 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr9_+_139871954 6.657 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr8_-_42397048 6.650 NM_006749
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr1_+_104198140 6.636 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr20_-_48531986 6.633 SPATA2
spermatogenesis associated 2
chr17_-_39743085 6.616 NM_000526
KRT14
keratin 14
chr12_-_10151689 6.602 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr22_-_38379868 6.584 SOX10
SRY (sex determining region Y)-box 10
chr7_+_153584383 6.563 NM_001039350
DPP6
dipeptidyl-peptidase 6
chr2_-_45236521 6.551 NM_016932
SIX2
SIX homeobox 2
chr1_+_165600433 6.544 MGST3
microsomal glutathione S-transferase 3
chr11_-_5255712 6.515 NM_000519
HBD
hemoglobin, delta
chr1_-_12677347 6.509 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_+_104198301 6.492 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr16_-_1877140 6.478 NM_001040427
NM_005326
HAGH

hydroxyacylglutathione hydrolase

chr3_+_52812438 6.445 NM_001166434
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr7_+_29519485 6.417 NM_001039936
CHN2
chimerin (chimaerin) 2
chr19_-_55668956 6.388 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr3_-_112280759 6.369 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr22_-_36013303 6.360 NM_005368
NM_203378
MB

myoglobin

chr9_+_17578952 6.349 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr14_+_100150596 6.326 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr1_-_57045214 6.291 PPAP2B
phosphatidic acid phosphatase type 2B
chr6_-_27806116 6.289 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr17_+_7211260 6.270 NM_001143761
EIF5A
eukaryotic translation initiation factor 5A
chr1_-_182922002 6.259 SHCBP1L
SHC SH2-domain binding protein 1-like
chr12_-_16759430 6.240 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_41614911 6.234 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr3_+_49027770 6.233 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr3_+_183873215 6.219 DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr1_+_1260142 6.218 NM_001029885
GLTPD1
glycolipid transfer protein domain containing 1
chr15_-_75230354 6.203 COX5A
cytochrome c oxidase subunit Va
chr20_+_32077904 6.202 NM_001032999
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr20_+_24450269 6.202 SYNDIG1
synapse differentiation inducing 1
chr20_-_44455932 6.186 NM_003279
TNNC2
troponin C type 2 (fast)
chr1_+_15764934 6.186 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr2_+_219646704 6.177 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr12_-_123466195 6.142 ABCB9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr9_-_131872782 6.131 CRAT
carnitine O-acetyltransferase
chr11_+_63742014 6.114 NM_004074
COX8A
cytochrome c oxidase subunit VIIIA (ubiquitous)
chr15_+_43885251 6.108 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chrX_+_152954965 6.083 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr3_+_183873305 6.062 DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr1_-_154155698 6.057 NM_001043351
NM_001043352
NM_001043353
NM_153649
TPM3



tropomyosin 3



chr6_-_52860076 6.047 NM_001512
GSTA4
glutathione S-transferase alpha 4
chr1_-_144997110 6.037 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr11_-_119293848 6.023 THY1
Thy-1 cell surface antigen
chr2_-_97303983 5.997 KANSL3
KAT8 regulatory NSL complex subunit 3
chr6_+_27833033 5.979 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr1_+_152635871 5.954 NM_178430
LCE2D
late cornified envelope 2D
chr9_+_139872014 5.948 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr12_-_11036815 5.933 NM_006250
PRH1
proline-rich protein HaeIII subfamily 1
chr6_+_43738757 5.925 VEGFA
vascular endothelial growth factor A
chr1_+_206224282 5.908 NM_000707
AVPR1B
arginine vasopressin receptor 1B
chr15_+_84115979 5.887 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr3_-_49460110 5.887 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr10_-_81320141 5.881 NM_001098668
SFTPA1
SFTPA2
surfactant protein A1
surfactant protein A2
chr12_-_6233684 5.844 NM_000552
VWF
von Willebrand factor
chr19_+_2328679 5.828 SPPL2B
signal peptide peptidase-like 2B
chr5_-_148034089 5.790 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr19_+_2328628 5.775 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr15_+_43985083 5.769 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr1_-_149889362 5.757 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr11_+_45907046 5.732 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr1_-_149858114 5.670 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr6_+_31982538 5.668 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr19_-_39322411 5.666 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr20_+_44036940 5.659 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr11_-_8832189 5.658 NM_213618
ST5
suppression of tumorigenicity 5
chr8_-_18541441 5.630 PSD3
pleckstrin and Sec7 domain containing 3
chr12_+_121163570 5.599 NM_000017
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 4.57e-25 GO:0009987 cellular process
1.33 3.47e-18 GO:0032501 multicellular organismal process
1.49 5.86e-17 GO:0048731 system development
1.46 6.43e-17 GO:0048856 anatomical structure development
1.38 6.53e-15 GO:0023052 signaling
1.38 1.55e-14 GO:0032502 developmental process
1.40 2.49e-14 GO:0007275 multicellular organismal development
1.20 3.06e-13 GO:0065007 biological regulation
1.51 4.34e-13 GO:0065008 regulation of biological quality
1.46 5.70e-11 GO:0042221 response to chemical stimulus
1.22 3.29e-10 GO:0050896 response to stimulus
1.34 1.29e-09 GO:0007165 signal transduction
1.53 7.72e-09 GO:0009653 anatomical structure morphogenesis
1.79 8.05e-09 GO:0007267 cell-cell signaling
1.28 1.00e-08 GO:0051716 cellular response to stimulus
2.11 1.84e-08 GO:0006091 generation of precursor metabolites and energy
1.34 2.58e-08 GO:0006810 transport
1.33 6.29e-08 GO:0051234 establishment of localization
1.17 8.78e-08 GO:0050789 regulation of biological process
1.42 8.82e-08 GO:0030154 cell differentiation
1.41 1.25e-07 GO:0048869 cellular developmental process
1.50 1.38e-07 GO:0007399 nervous system development
1.42 5.20e-07 GO:0048513 organ development
1.80 7.38e-07 GO:0009887 organ morphogenesis
1.28 9.03e-07 GO:0051179 localization
2.17 4.56e-06 GO:0015980 energy derivation by oxidation of organic compounds
3.06 7.92e-06 GO:0022904 respiratory electron transport chain
1.49 8.06e-06 GO:0010033 response to organic substance
2.51 8.42e-06 GO:0006936 muscle contraction
1.56 8.46e-06 GO:0007154 cell communication
1.49 8.90e-06 GO:0051239 regulation of multicellular organismal process
1.73 9.80e-06 GO:0048878 chemical homeostasis
2.41 1.64e-05 GO:0003012 muscle system process
1.39 2.05e-05 GO:0007166 cell surface receptor linked signaling pathway
2.67 3.42e-05 GO:0045333 cellular respiration
1.15 4.30e-05 GO:0050794 regulation of cellular process
1.81 7.36e-05 GO:0006066 alcohol metabolic process
1.55 9.28e-05 GO:0055114 oxidation-reduction process
1.57 9.75e-05 GO:0009888 tissue development
1.53 1.87e-04 GO:0048468 cell development
1.52 2.47e-04 GO:0070887 cellular response to chemical stimulus
1.52 3.27e-04 GO:0050793 regulation of developmental process
1.77 4.52e-04 GO:0055082 cellular chemical homeostasis
2.48 4.58e-04 GO:0022900 electron transport chain
1.52 6.91e-04 GO:0042592 homeostatic process
1.68 7.24e-04 GO:0019725 cellular homeostasis
1.49 7.41e-04 GO:0006629 lipid metabolic process
2.17 7.52e-04 GO:0010817 regulation of hormone levels
1.76 8.50e-04 GO:0006873 cellular ion homeostasis
1.50 9.53e-04 GO:0022008 neurogenesis
1.56 9.71e-04 GO:2000026 regulation of multicellular organismal development
1.13 9.78e-04 GO:0008152 metabolic process
2.94 1.12e-03 GO:0034754 cellular hormone metabolic process
3.25 1.45e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.50 2.10e-03 GO:0048699 generation of neurons
2.33 2.33e-03 GO:0006006 glucose metabolic process
1.32 2.41e-03 GO:0048583 regulation of response to stimulus
1.72 2.61e-03 GO:0007268 synaptic transmission
2.01 2.63e-03 GO:0008202 steroid metabolic process
1.56 2.92e-03 GO:0030182 neuron differentiation
1.67 3.12e-03 GO:0019226 transmission of nerve impulse
1.67 3.12e-03 GO:0035637 multicellular organismal signaling
2.11 3.16e-03 GO:0007517 muscle organ development
1.69 3.23e-03 GO:0050801 ion homeostasis
1.25 3.23e-03 GO:0048518 positive regulation of biological process
1.78 3.70e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.70 4.67e-03 GO:0032583 regulation of gene-specific transcription
1.55 4.81e-03 GO:0045595 regulation of cell differentiation
1.32 6.62e-03 GO:0003008 system process
1.66 8.24e-03 GO:0072358 cardiovascular system development
1.66 8.24e-03 GO:0072359 circulatory system development
2.22 8.46e-03 GO:0042445 hormone metabolic process
1.31 9.13e-03 GO:0044281 small molecule metabolic process
4.41 1.02e-02 GO:0046470 phosphatidylcholine metabolic process
1.77 1.46e-02 GO:0044057 regulation of system process
2.25 1.51e-02 GO:0060537 muscle tissue development
1.42 1.54e-02 GO:0009605 response to external stimulus
1.52 1.58e-02 GO:0009719 response to endogenous stimulus
1.84 1.85e-02 GO:0061061 muscle structure development
1.79 1.87e-02 GO:0022603 regulation of anatomical structure morphogenesis
2.17 1.94e-02 GO:0045165 cell fate commitment
1.55 2.00e-02 GO:0009725 response to hormone stimulus
2.89 2.20e-02 GO:0072376 protein activation cascade
1.79 2.95e-02 GO:0019932 second-messenger-mediated signaling
1.25 3.34e-02 GO:0048519 negative regulation of biological process
1.80 3.95e-02 GO:0010035 response to inorganic substance
3.20 4.15e-02 GO:0006096 glycolysis
1.57 4.42e-02 GO:0080134 regulation of response to stress
1.38 4.45e-02 GO:0010646 regulation of cell communication
1.73 4.65e-02 GO:0051093 negative regulation of developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 1.53e-11 GO:0044459 plasma membrane part
1.73 4.28e-09 GO:0005615 extracellular space
1.60 2.10e-08 GO:0044421 extracellular region part
1.52 5.81e-08 GO:0031226 intrinsic to plasma membrane
1.51 1.70e-07 GO:0005887 integral to plasma membrane
1.62 8.08e-07 GO:0005624 membrane fraction
3.67 8.32e-07 GO:0000786 nucleosome
1.52 1.01e-06 GO:0000267 cell fraction
1.61 1.16e-06 GO:0005626 insoluble fraction
2.65 6.06e-06 GO:0043292 contractile fiber
1.33 1.43e-05 GO:0005576 extracellular region
2.65 2.31e-05 GO:0044449 contractile fiber part
2.58 4.71e-05 GO:0030016 myofibril
1.89 1.20e-04 GO:0005743 mitochondrial inner membrane
1.15 2.43e-04 GO:0044444 cytoplasmic part
2.42 3.66e-04 GO:0044455 mitochondrial membrane part
1.11 3.75e-04 GO:0005737 cytoplasm
1.73 4.63e-04 GO:0045202 synapse
1.48 5.00e-04 GO:0042995 cell projection
2.60 5.46e-04 GO:0032993 protein-DNA complex
2.52 1.08e-03 GO:0030017 sarcomere
1.70 1.09e-03 GO:0043005 neuron projection
1.76 1.34e-03 GO:0019866 organelle inner membrane
1.81 1.74e-03 GO:0044456 synapse part
2.05 2.06e-03 GO:0030424 axon
1.54 2.72e-03 GO:0030054 cell junction
5.87 3.97e-03 GO:0005833 hemoglobin complex
1.17 4.38e-03 GO:0005886 plasma membrane
1.60 4.77e-03 GO:0005740 mitochondrial envelope
1.61 5.59e-03 GO:0031966 mitochondrial membrane
1.16 6.65e-03 GO:0071944 cell periphery
1.47 1.04e-02 GO:0044429 mitochondrial part
2.67 1.14e-02 GO:0070469 respiratory chain
3.00 1.50e-02 GO:0031093 platelet alpha granule lumen
2.88 1.55e-02 GO:0031983 vesicle lumen
2.02 1.77e-02 GO:0045211 postsynaptic membrane
2.94 2.01e-02 GO:0034774 secretory granule lumen
1.69 2.38e-02 GO:0015629 actin cytoskeleton
1.77 3.24e-02 GO:0016323 basolateral plasma membrane
2.82 3.53e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.59 4.22e-02 GO:0031012 extracellular matrix
2.60 4.24e-02 GO:0005746 mitochondrial respiratory chain
1.81 4.92e-02 GO:0030141 stored secretory granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.51 5.22e-07 GO:0005215 transporter activity
1.08 2.36e-06 GO:0005488 binding
3.75 4.03e-06 GO:0004879 ligand-dependent nuclear receptor activity
3.80 6.53e-06 GO:0003707 steroid hormone receptor activity
1.14 1.07e-05 GO:0005515 protein binding
1.51 1.77e-05 GO:0022892 substrate-specific transporter activity
1.58 1.17e-04 GO:0016491 oxidoreductase activity
1.55 2.37e-04 GO:0015075 ion transmembrane transporter activity
1.56 4.47e-04 GO:0043565 sequence-specific DNA binding
1.61 6.91e-04 GO:0008324 cation transmembrane transporter activity
1.46 7.77e-04 GO:0022857 transmembrane transporter activity
1.87 1.81e-03 GO:0005261 cation channel activity
1.45 2.23e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.68 2.53e-03 GO:0015267 channel activity
1.67 2.78e-03 GO:0022803 passive transmembrane transporter activity
1.68 2.94e-03 GO:0022838 substrate-specific channel activity
1.79 3.13e-03 GO:0022836 gated channel activity
1.69 3.17e-03 GO:0005216 ion channel activity
1.53 5.71e-03 GO:0005198 structural molecule activity
1.39 6.90e-03 GO:0005102 receptor binding
2.22 1.01e-02 GO:0020037 heme binding
2.19 1.43e-02 GO:0015276 ligand-gated ion channel activity
2.19 1.43e-02 GO:0022834 ligand-gated channel activity
2.15 1.47e-02 GO:0046906 tetrapyrrole binding
5.42 1.69e-02 GO:0005344 oxygen transporter activity
1.38 2.17e-02 GO:0001071 nucleic acid binding transcription factor activity
1.38 2.17e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.76 2.58e-02 GO:0032403 protein complex binding
3.88 3.09e-02 GO:0050840 extracellular matrix binding
1.42 4.34e-02 GO:0019899 enzyme binding
1.86 4.37e-02 GO:0010843 promoter binding
1.66 4.70e-02 GO:0003779 actin binding
1.45 4.75e-02 GO:0005509 calcium ion binding