Motif ID: NR6A1.p2

Z-value: 1.264


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR6A1chr9_-_1275333970.421.0e-10Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_6720585 47.207 NM_000064
C3
complement component 3
chr17_-_48264039 44.376 COL1A1
collagen, type I, alpha 1
chr22_+_23229959 27.017 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr1_+_19923457 20.471 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr2_-_224903324 19.651 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_-_14313899 18.506 NFIB
nuclear factor I/B
chr7_-_150038689 17.666 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr15_+_101420004 16.815 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr3_-_52312257 15.613 WDR82
WD repeat domain 82
chr9_-_14313509 15.420 NFIB
nuclear factor I/B
chr14_-_106967528 14.842 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr7_+_100199881 13.468 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr16_+_56642477 12.911 NM_005953
MT2A
metallothionein 2A
chr9_-_14314036 12.037 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr9_+_124043719 11.477 GSN
gelsolin
chr15_+_101420032 11.201 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr6_+_129204285 9.691 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr17_-_29624249 8.772 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr14_-_106111114 7.502 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr6_+_31973358 7.464 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr14_-_106539099 7.154 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr3_+_133464883 6.988 NM_001063
TF
transferrin
chr10_-_126107493 6.832 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr1_+_225997742 6.784 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr10_+_89419352 6.713 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr9_-_38069082 6.103 SHB
Src homology 2 domain containing adaptor protein B
chr12_+_109273856 5.999 NM_001917
DAO
D-amino-acid oxidase
chr1_+_225997804 5.924 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr14_-_106453162 5.869 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_123754141 5.277 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_+_133465204 5.025 TF
transferrin
chr2_+_18059923 4.408 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr14_-_106471439 4.018 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr2_-_162930629 3.926 DPP4
dipeptidyl-peptidase 4
chr9_-_38069207 3.879 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr3_+_46619075 3.808 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr12_-_16760935 3.776 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr13_+_23755059 3.725 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr3_+_133465098 3.704 TF
transferrin
chr9_+_35792405 3.697 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr13_-_42535066 3.469 KIAA0564
KIAA0564
chr22_-_24059436 3.400


chr14_-_106733392 3.365 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr9_-_21228132 3.359 NM_021268
IFNA17
interferon, alpha 17
chr9_-_21217303 3.315 NM_002173
IFNA16
interferon, alpha 16
chr10_-_126107454 3.306 OAT
ornithine aminotransferase
chr2_+_33701678 3.297 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chrX_-_138724851 3.281 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chrX_+_48620153 3.240 NM_001080489
GLOD5
glyoxalase domain containing 5
chr7_+_28530747 2.777 CREB5
cAMP responsive element binding protein 5
chr1_+_78511588 2.751 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr2_-_162930500 2.677 DPP4
dipeptidyl-peptidase 4
chr2_-_162930544 2.624 DPP4
dipeptidyl-peptidase 4
chr16_+_1386197 2.539 NM_001199096
BAIAP3
BAI1-associated protein 3
chr9_-_21166609 2.526 NM_002175
IFNA21
interferon, alpha 21
chr4_-_48014960 2.516 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr8_+_142432006 2.499 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr2_+_33172368 2.492 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr22_-_24059502 2.348 GUSBP11
glucuronidase, beta pseudogene 11
chr9_-_14313943 2.329 NFIB
nuclear factor I/B
chr5_+_140749830 2.281 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr7_-_137531585 2.150 NM_004717
DGKI
diacylglycerol kinase, iota
chr1_-_20834609 2.130 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr12_+_7169192 2.082


chr6_-_132910824 2.065 NM_003967
TAAR5
trace amine associated receptor 5
chr12_-_58135853 2.002 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr6_-_43484503 1.902 YIPF3
Yip1 domain family, member 3
chr1_-_20834516 1.886 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr11_+_35684418 1.800 TRIM44
tripartite motif containing 44
chr12_+_2921786 1.749 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr22_-_24059524 1.735 GUSBP11
glucuronidase, beta pseudogene 11
chr20_-_3149070 1.711 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr2_-_162929928 1.693 DPP4
dipeptidyl-peptidase 4
chr5_-_41213513 1.690 NM_000065
C6
complement component 6
chr16_-_3306586 1.663 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr1_-_161102457 1.633 NM_001039711
NM_032998
DEDD

death effector domain containing

chr5_-_65017874 1.606 NM_019072
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr19_-_43709692 1.502 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr9_-_21207141 1.467 NM_002171
IFNA10
interferon, alpha 10
chr19_+_496453 1.435 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr8_-_145701139 1.283 FOXH1
forkhead box H1
chr8_-_93115453 1.233 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr12_+_100897137 1.217 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr2_-_241759627 1.142 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr1_+_212738675 1.137 NM_001030287
ATF3
activating transcription factor 3
chr12_+_108956293 1.135 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr14_-_106641585 1.126 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_+_71709951 1.091 NM_001039659
NM_001039660
NM_173044
NM_005699
NM_173042
IL18BP




interleukin 18 binding protein




chr1_+_9299902 1.075 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr19_-_5846465 1.075 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr7_-_2883649 1.064 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr6_-_43484701 1.055 NM_015388
YIPF3
Yip1 domain family, member 3
chr2_-_211090146 0.997 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr1_+_176432306 0.987 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr2_-_31361591 0.977 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr4_-_89205667 0.974 PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr19_-_15083729 0.970 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr16_+_3451154 0.868 NM_001032292
NM_003450
ZNF174

zinc finger protein 174

chr3_+_186383770 0.791 NM_000412
HRG
histidine-rich glycoprotein
chr8_-_145701717 0.780 NM_003923
FOXH1
forkhead box H1
chr12_-_110252600 0.764 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr12_-_7261788 0.763 NM_016546
C1RL
complement component 1, r subcomponent-like
chr6_-_32339648 0.754 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr17_+_12692779 0.735 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chr7_-_126883568 0.713 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr4_+_41614725 0.686 LIMCH1
LIM and calponin homology domains 1
chr7_+_73868236 0.683 GTF2IRD1
GTF2I repeat domain containing 1
chr1_+_26503973 0.653 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr16_+_56995761 0.632 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr1_+_63063186 0.621 NM_014495
ANGPTL3
angiopoietin-like 3
chr14_-_106967080 0.597 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_185046682 0.590 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_-_40236926 0.589 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr19_+_41620336 0.557 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr14_-_106452693 0.503 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_51041561 0.480 NM_016431
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chrX_+_47229981 0.469 NM_003446
ZNF157
zinc finger protein 157
chr4_-_90758126 0.457 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr2_+_24150144 0.445 UBXN2A
UBX domain protein 2A
chr7_-_87936202 0.417 NM_001205315
NM_001205316
NM_024636
STEAP4


STEAP family member 4


chr12_-_10562142 0.416 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chrX_+_8432870 0.364 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr11_+_66314373 0.360 NM_001104
ACTN3
actinin, alpha 3
chr11_+_111957611 0.325 SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr14_-_47120940 0.299 NM_080746
RPL10L
ribosomal protein L10-like
chr1_+_6684924 0.280 NM_001195753
THAP3
THAP domain containing, apoptosis associated protein 3
chrX_-_104465349 0.249 NM_031274
TEX13A
testis expressed 13A
chr9_+_37485911 0.237 NM_022490
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr18_+_33767420 0.214 NM_017947
MOCOS
molybdenum cofactor sulfurase
chr3_-_128294928 0.206 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr9_-_130679210 0.202 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr12_-_6484389 0.176 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr21_-_37914897 0.165 NM_001146078
CLDN14
claudin 14
chr16_+_31494438 0.160 NM_003041
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr11_+_66624501 0.133 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_118754474 0.130 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr3_+_46411632 0.108 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr11_-_111957417 0.106 NM_012459
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chrX_-_8139307 0.070 NM_016378
VCX2
variable charge, X-linked 2
chr9_-_134955056 0.044 MED27
mediator complex subunit 27
chr7_-_100240334 0.016 TFR2
transferrin receptor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.07 1.11e-04 GO:0006955 immune response
3.01 1.02e-03 GO:0002376 immune system process
20.81 2.38e-03 GO:0002455 humoral immune response mediated by circulating immunoglobulin
2.43 4.31e-03 GO:0048583 regulation of response to stimulus
11.81 7.20e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.50 8.40e-03 GO:0002250 adaptive immune response
13.24 2.29e-02 GO:0016064 immunoglobulin mediated immune response
13.01 2.50e-02 GO:0019724 B cell mediated immunity
145.59 2.90e-02 GO:0001969 regulation of activation of membrane attack complex
145.59 2.90e-02 GO:0001970 positive regulation of activation of membrane attack complex
145.59 2.90e-02 GO:0045917 positive regulation of complement activation
145.59 2.90e-02 GO:2000259 positive regulation of protein activation cascade
19.42 3.12e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway
18.79 3.57e-02 GO:0006958 complement activation, classical pathway
36.40 4.12e-02 GO:0010953 regulation of protein maturation by peptide bond cleavage
36.40 4.12e-02 GO:0070613 regulation of protein processing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.37 4.01e-04 GO:0005576 extracellular region
3.43 5.67e-04 GO:0005624 membrane fraction
3.33 8.84e-04 GO:0005626 insoluble fraction
2.68 9.87e-03 GO:0000267 cell fraction
2.72 1.29e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
25.48 1.52e-06 GO:0003823 antigen binding