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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: PAX5.p2

Z-value: 2.317

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_-_2950593	35.367	NM_003311	PHLDA2	pleckstrin homology-like domain, family A, member 2
chr6_-_4135701	32.301	NM_001166010 NM_006117 NM_206836	ECI2	enoyl-CoA delta isomerase 2
chr2_+_235860616	31.114	NM_014521	SH3BP4	SH3-domain binding protein 4
chr16_+_1359653	30.440		UBE2I	ubiquitin-conjugating enzyme E2I
chrX_+_133594171	30.367	NM_000194	HPRT1	hypoxanthine phosphoribosyltransferase 1
chr16_+_1359636	30.227		UBE2I	ubiquitin-conjugating enzyme E2I
chr16_+_1359692	29.497		UBE2I	ubiquitin-conjugating enzyme E2I
chr20_+_388941	28.866		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chrX_+_133594225	28.771		HPRT1	hypoxanthine phosphoribosyltransferase 1
chr16_+_1359673	28.224		UBE2I	ubiquitin-conjugating enzyme E2I
chr2_-_215674292	25.640	NM_000465	BARD1	BRCA1 associated RING domain 1
chr3_-_185542807	24.497	NM_001007225 NM_006548	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr2_-_179315756	24.307	NM_003690	PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator
chr19_-_291168	24.239	NM_177543	PPAP2C	phosphatidic acid phosphatase type 2C
chr4_+_57302268	24.143	NM_001079524 NM_001079525	PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr7_+_26241281	23.174	NM_016587	CBX3	chromobox homolog 3
chrX_+_118602391	22.937		SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr20_+_62371218	22.762		SLC2A4RG	SLC2A4 regulator
chr7_-_105752650	22.615		SYPL1	synaptophysin-like 1
chr20_+_62371109	22.556	NM_020062	SLC2A4RG	SLC2A4 regulator
chrX_+_133594297	22.284		HPRT1	hypoxanthine phosphoribosyltransferase 1
chrX_+_118602362	22.147	NM_001152	SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr5_+_122110778	22.030		SNX2	sorting nexin 2
chr18_+_29671925	21.423		RNF138	ring finger protein 138
chr4_+_57301898	21.023	NM_006452	PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr7_-_105925329	20.994		NAMPT	nicotinamide phosphoribosyltransferase
chr12_-_109125254	20.978		CORO1C	coronin, actin binding protein, 1C
chr18_+_11981421	20.888	NM_014214	IMPA2	inositol(myo)-1(or 4)-monophosphatase 2
chr1_+_87170515	20.554		SH3GLB1	SH3-domain GRB2-like endophilin B1
chr21_+_45139169	20.548		PDXK	pyridoxal (pyridoxine, vitamin B6) kinase
chr9_+_131451823	20.508		SET	SET nuclear oncogene
chr18_+_657674	19.894		TYMS	thymidylate synthetase
chr14_+_56046796	19.871	NM_001079521 NM_001079522 NM_004986 NM_182926	KTN1	kinectin 1 (kinesin receptor)
chr2_-_174829108	19.651		SP3	Sp3 transcription factor
chr13_+_28196029	19.500		POLR1D	polymerase (RNA) I polypeptide D, 16kDa
chr20_+_57556322	19.237		TH1L	TH1-like (Drosophila)
chr3_+_128997713	19.157	NM_001006109	C3orf37	chromosome 3 open reading frame 37
chr13_+_28196024	18.936		POLR1D	polymerase (RNA) I polypeptide D, 16kDa
chrX_-_152989822	18.901	NM_005745	BCAP31	B-cell receptor-associated protein 31
chr18_+_29671817	18.160	NM_016271	RNF138	ring finger protein 138
chr15_+_57210852	18.128		TCF12	transcription factor 12
chr2_-_32236104	18.124		MEMO1	mediator of cell motility 1
chr6_-_18264638	17.998	NM_001134709 NM_003472	DEK	DEK oncogene
chr2_+_85198176	17.931	NM_020122	KCMF1	potassium channel modulatory factor 1
chr18_+_12308236	17.882		TUBB6	tubulin, beta 6 class V
chr2_+_238600780	17.751	NM_001137551 NM_001137552 NM_001137553 NM_004735	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1
chr7_+_26241372	17.688		CBX3	chromobox homolog 3
chr2_+_238600878	17.636		LRRFIP1	leucine rich repeat (in FLII) interacting protein 1
chr12_-_109125289	17.608	NM_014325	CORO1C	coronin, actin binding protein, 1C
chr21_-_46293609	17.433	NM_004339	PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr3_-_53289957	17.411		TKT	transketolase
chr11_-_64014264	17.318		PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr5_+_68462948	17.317		CCNB1	cyclin B1
chr5_+_68462836	17.288	NM_031966	CCNB1	cyclin B1
chr17_-_62658311	17.265	NM_022739	SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr9_+_131451847	17.169		SET	SET nuclear oncogene
chr5_+_68462985	16.986		CCNB1	cyclin B1
chr5_+_122110737	16.880	NM_003100	SNX2	sorting nexin 2
chr15_+_57210972	16.855		TCF12	transcription factor 12
chr12_+_3068442	16.819	NM_003213 NM_201441 NM_201443	TEAD4	TEA domain family member 4
chr20_+_388717	16.536		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr10_+_28822387	16.386	NM_016628 NM_100486	WAC	WW domain containing adaptor with coiled-coil
chr18_+_29078026	16.273	NM_001943	DSG2	desmoglein 2
chr18_+_34409058	16.240	NM_020776	KIAA1328	KIAA1328
chr12_-_109125275	16.237		CORO1C	coronin, actin binding protein, 1C
chr1_+_87170486	16.181		SH3GLB1	SH3-domain GRB2-like endophilin B1
chr2_+_10262853	16.145	NM_001034	RRM2	ribonucleotide reductase M2
chr2_+_10262694	15.982	NM_001165931	RRM2	ribonucleotide reductase M2
chr21_-_46293561	15.942		PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr19_-_1567875	15.913	NM_001174118 NM_203304	MEX3D	mex-3 homolog D (C. elegans)
chr19_-_291335	15.818	NM_003712 NM_177526	PPAP2C	phosphatidic acid phosphatase type 2C
chr3_-_53290099	15.807	NM_001064 NM_001135055	TKT	transketolase
chr5_+_95998170	15.754		CAST	calpastatin
chr7_+_26241329	15.704		CBX3	chromobox homolog 3
chr13_+_28196004	15.476		POLR1D	polymerase (RNA) I polypeptide D, 16kDa
chr11_-_34937831	15.446	NM_015957	APIP	APAF1 interacting protein
chr18_+_12308242	15.419	NM_032525	TUBB6	tubulin, beta 6 class V
chr10_+_120863626	15.380		FAM45A FAM45B	family with sequence similarity 45, member A family with sequence similarity 45, member A pseudogene
chr12_-_13153047	15.296		HEBP1	heme binding protein 1
chr4_+_1723233	15.257		TACC3	transforming, acidic coiled-coil containing protein 3
chr18_+_11981552	15.257		IMPA2	inositol(myo)-1(or 4)-monophosphatase 2
chr7_+_26241044	15.231		CBX3	chromobox homolog 3
chr8_+_145149936	15.089	NM_001916	CYC1	cytochrome c-1
chr17_-_80606095	15.081	NM_019613	WDR45L	WDR45-like
chr4_+_1723212	15.043	NM_006342	TACC3	transforming, acidic coiled-coil containing protein 3
chr17_-_62658175	15.010		SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr2_+_181845368	14.896		UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr17_-_62657997	14.848		SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chrX_-_152989851	14.842		BCAP31	B-cell receptor-associated protein 31
chr9_+_110046333	14.840	NM_001244724	RAD23B	RAD23 homolog B (S. cerevisiae)
chr2_-_179315354	14.836	NM_001139518 NM_001139517	PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator
chr3_+_23847349	14.834	NM_003341 NM_182666	UBE2E1	ubiquitin-conjugating enzyme E2E 1
chr7_-_105752718	14.713	NM_182715	SYPL1	synaptophysin-like 1
chr18_-_812268	14.620	NM_005433	YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr17_+_35849997	14.549		DUSP14	dual specificity phosphatase 14
chr1_+_955468	14.434	NM_198576	AGRN	agrin
chr8_+_145149978	14.410		CYC1	cytochrome c-1
chr21_-_46293532	14.325		PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr1_+_87170286	14.279		SH3GLB1	SH3-domain GRB2-like endophilin B1
chr21_-_46293598	14.239		PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr19_+_35645640	14.226	NM_144779 NM_001164605	FXYD5	FXYD domain containing ion transport regulator 5
chr10_+_120863610	14.139	NM_207009	FAM45A	family with sequence similarity 45, member A
chr18_+_12947972	14.139	NM_001013437 NM_031216	SEH1L	SEH1-like (S. cerevisiae)
chr13_+_28195913	14.063	NM_015972 NM_152705	POLR1D	polymerase (RNA) I polypeptide D, 16kDa
chr15_-_34331185	14.054	NM_020371	AVEN	apoptosis, caspase activation inhibitor
chr18_-_34408845	14.044		TPGS2	tubulin polyglutamylase complex subunit 2
chr7_-_105752974	14.042	NM_006754	SYPL1	synaptophysin-like 1
chr19_-_55918980	14.033		UBE2S	ubiquitin-conjugating enzyme E2S
chr12_-_13153200	13.914	NM_015987	HEBP1	heme binding protein 1
chr2_+_85198431	13.910		KCMF1	potassium channel modulatory factor 1
chr15_+_57210823	13.810	NM_003205 NM_207036 NM_207037 NM_207038	TCF12	transcription factor 12
chr10_+_88854900	13.810	NM_019054	FAM35A	family with sequence similarity 35, member A
chr20_+_57556295	13.714	NM_198976	TH1L	TH1-like (Drosophila)
chr15_-_60690115	13.679	NM_001002857 NM_001002858 NM_001136015 NM_004039	ANXA2	annexin A2
chr9_+_114423888	13.548		GNG10	guanine nucleotide binding protein (G protein), gamma 10
chr3_+_128997616	13.543	NM_020187	C3orf37	chromosome 3 open reading frame 37
chr10_+_124914279	13.313		BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)
chr12_-_76425207	13.302		PHLDA1	pleckstrin homology-like domain, family A, member 1
chr12_+_69004710	13.188		RAP1B	RAP1B, member of RAS oncogene family
chr15_-_59949536	13.058	NM_004492	GTF2A2	general transcription factor IIA, 2, 12kDa
chr1_+_43824598	12.950	NM_001255	CDC20	cell division cycle 20 homolog (S. cerevisiae)
chr3_-_182698291	12.915	NM_020640	DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr2_+_109150807	12.897	NM_001193483	LIMS1	LIM and senescent cell antigen-like domains 1
chr1_-_1822501	12.826		GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1
chr12_+_131356640	12.755		RAN	RAN, member RAS oncogene family
chr10_+_82213892	12.715	NM_001128309 NM_030927	TSPAN14	tetraspanin 14
chr3_-_69129502	12.672	NM_003968 NM_198195	UBA3	ubiquitin-like modifier activating enzyme 3
chr21_+_42540054	12.655		BACE2	beta-site APP-cleaving enzyme 2
chr2_-_9770366	12.573		YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr21_+_42540092	12.568		BACE2	beta-site APP-cleaving enzyme 2
chr17_-_15466772	12.554	NM_001204478 NM_001135036 NM_145301	FAM18B2-CDRT4 FAM18B2	FAM18B2-CDRT4 readthrough family with sequence similarity 18, member B2
chr3_+_100428393	12.523		TFG	TRK-fused gene
chr8_+_97274106	12.489		PTDSS1	phosphatidylserine synthase 1
chr7_+_116139619	12.465	NM_001206747 NM_001233 NM_198212	CAV2	caveolin 2
chr3_-_185542744	12.419		IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr2_+_181845803	12.402		UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr15_-_59225766	12.391		SLTM	SAFB-like, transcription modulator
chr5_+_95997871	12.373	NM_001042440	CAST	calpastatin
chr20_+_55926299	12.296		RAE1	RAE1 RNA export 1 homolog (S. pombe)
chr11_+_101980736	12.290	NM_001130145 NM_001195044 NM_006106	YAP1	Yes-associated protein 1
chr7_+_87505543	12.267	NM_006716	DBF4	DBF4 homolog (S. cerevisiae)
chr2_+_181845605	12.267		UBE2E3	ubiquitin-conjugating enzyme E2E 3
chrX_-_152989807	12.209
chr15_+_80352043	12.179		ZFAND6	zinc finger, AN1-type domain 6
chr9_+_131452253	12.177	NM_001248001	SET	SET nuclear oncogene
chr5_+_10353980	12.158
chr6_+_158589378	11.941	NM_207118	GTF2H5	general transcription factor IIH, polypeptide 5
chr3_+_100053544	11.909	NM_020202	NIT2	nitrilase family, member 2
chr1_-_152009406	11.908		S100A11	S100 calcium binding protein A11
chr11_+_1968499	11.879	NM_021134	MRPL23	mitochondrial ribosomal protein L23
chr2_-_234763145	11.854		HJURP	Holliday junction recognition protein
chr21_-_45196200	11.725	NM_000100	CSTB	cystatin B (stefin B)
chr20_+_32581553	11.631		RALY	RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr14_+_97263681	11.597	NM_003384	VRK1	vaccinia related kinase 1
chr1_+_162531229	11.563	NM_003115	UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1
chr3_-_52567809	11.520		NT5DC2	5'-nucleotidase domain containing 2
chr20_+_60878024	11.507	NM_007002 NM_175573	ADRM1	adhesion regulating molecule 1
chr10_+_88516340	11.505	NM_004329	BMPR1A	bone morphogenetic protein receptor, type IA
chr13_+_98628712	11.486		IPO5	importin 5
chr18_-_34408948	11.422		TPGS2	tubulin polyglutamylase complex subunit 2
chr16_-_87903028	11.418	NM_003486	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr9_+_131451470	11.414	NM_003011	SET	SET nuclear oncogene
chr11_-_64014407	11.357	NM_138689	PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_-_234763182	11.220	NM_018410	HJURP	Holliday junction recognition protein
chr18_-_9614555	11.198	NM_001042388 NM_005134	PPP4R1	protein phosphatase 4, regulatory subunit 1
chr20_+_61427804	11.097	NM_018270	C20orf20	chromosome 20 open reading frame 20
chr18_+_29672568	11.096	NM_001191324 NM_198128	RNF138	ring finger protein 138
chr1_+_955609	11.093		AGRN	agrin
chr18_-_9614454	10.915		PPP4R1	protein phosphatase 4, regulatory subunit 1
chr15_+_80352018	10.902		ZFAND6	zinc finger, AN1-type domain 6
chr16_+_81040120	10.875		CENPN	centromere protein N
chr17_+_37026309	10.866		LASP1	LIM and SH3 protein 1
chr1_-_8938745	10.862		ENO1	enolase 1, (alpha)
chr2_+_181845088	10.848	NM_182678 NM_006357	UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr12_+_121837843	10.835	NM_025126 NM_194271	RNF34	ring finger protein 34
chr1_-_152009440	10.831		S100A11	S100 calcium binding protein A11
chr21_-_46238040	10.799	NM_006936	SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr22_+_43547558	10.786		TSPO	translocator protein (18kDa)
chr16_+_88923490	10.771	NM_016209	TRAPPC2L	trafficking protein particle complex 2-like
chr1_-_8939150	10.736	NM_001428	ENO1	enolase 1, (alpha)
chr2_-_9770999	10.679		YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr3_+_171758289	10.679	NM_001135095	FNDC3B	fibronectin type III domain containing 3B
chr7_-_105925410	10.651	NM_005746	NAMPT	nicotinamide phosphoribosyltransferase
chr14_+_73603140	10.552	NM_000021 NM_007318	PSEN1	presenilin 1
chr16_-_50402685	10.529	NM_001173984 NM_013263	BRD7	bromodomain containing 7
chr20_-_33872571	10.513	NM_002212 NM_181466	EIF6	eukaryotic translation initiation factor 6
chr7_+_26240830	10.382	NM_007276	CBX3	chromobox homolog 3
chr10_+_81107219	10.373	NM_005729	PPIF	peptidylprolyl isomerase F
chr15_+_57210889	10.367		TCF12	transcription factor 12
chr15_+_80352257	10.350	NM_001242913	ZFAND6	zinc finger, AN1-type domain 6
chr11_+_34938112	10.335		PDHX	pyruvate dehydrogenase complex, component X
chr1_-_8938727	10.334		ENO1	enolase 1, (alpha)
chr14_+_100705101	10.324	NM_003403	YY1	YY1 transcription factor
chr14_-_102553344	10.322		HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1
chr11_+_65686727	10.321	NM_006442	DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)
chr15_-_90777144	10.288		CIB1	calcium and integrin binding 1 (calmyrin)
chr16_-_81129882	10.233	NM_004483	GCSH	glycine cleavage system protein H (aminomethyl carrier)
chr17_+_35849950	10.232	NM_007026	DUSP14	dual specificity phosphatase 14
chr20_-_33872505	10.221	NM_181468	EIF6	eukaryotic translation initiation factor 6
chr10_+_95256348	10.215	NM_001127182 NM_018131	CEP55	centrosomal protein 55kDa

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.17	5.29e-58	GO:0009987	cellular process
1.31	6.56e-52	GO:0044237	cellular metabolic process
1.26	3.92e-46	GO:0008152	metabolic process
1.28	3.58e-42	GO:0044238	primary metabolic process
1.33	8.04e-34	GO:0044260	cellular macromolecule metabolic process
1.28	4.66e-30	GO:0043170	macromolecule metabolic process
1.19	5.12e-29	GO:0065007	biological regulation
1.20	1.08e-27	GO:0050789	regulation of biological process
1.35	1.41e-26	GO:0006807	nitrogen compound metabolic process
1.35	2.95e-25	GO:0034641	cellular nitrogen compound metabolic process
1.40	8.49e-24	GO:0048522	positive regulation of cellular process
1.20	9.80e-24	GO:0050794	regulation of cellular process
1.37	1.33e-23	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.37	2.04e-23	GO:0048518	positive regulation of biological process
1.32	1.90e-22	GO:0016043	cellular component organization
1.31	5.60e-22	GO:0071840	cellular component organization or biogenesis
1.36	9.60e-18	GO:0042221	response to chemical stimulus
1.32	3.47e-16	GO:0071842	cellular component organization at cellular level
1.31	3.54e-16	GO:0071841	cellular component organization or biogenesis at cellular level
1.35	4.67e-16	GO:0090304	nucleic acid metabolic process
1.48	6.56e-16	GO:0010033	response to organic substance
1.32	3.44e-15	GO:0044267	cellular protein metabolic process
1.49	7.28e-15	GO:0044248	cellular catabolic process
1.23	1.89e-14	GO:0051716	cellular response to stimulus
1.43	2.63e-14	GO:0009056	catabolic process
1.31	1.03e-13	GO:0044249	cellular biosynthetic process
1.27	5.13e-13	GO:0019538	protein metabolic process
1.32	1.24e-12	GO:0048523	negative regulation of cellular process
1.43	1.43e-12	GO:0051641	cellular localization
1.29	1.76e-12	GO:0009058	biosynthetic process
1.56	2.01e-12	GO:0046907	intracellular transport
1.22	4.63e-12	GO:0019222	regulation of metabolic process
1.45	5.09e-12	GO:0010604	positive regulation of macromolecule metabolic process
1.47	1.50e-11	GO:0007049	cell cycle
1.29	1.54e-11	GO:0048519	negative regulation of biological process
1.42	1.87e-11	GO:0009893	positive regulation of metabolic process
1.46	6.14e-11	GO:0042981	regulation of apoptosis
1.45	7.24e-11	GO:0043067	regulation of programmed cell death
1.44	7.73e-11	GO:0051649	establishment of localization in cell
1.34	1.19e-10	GO:0016070	RNA metabolic process
1.44	1.49e-10	GO:0010941	regulation of cell death
1.41	1.77e-10	GO:0031325	positive regulation of cellular metabolic process
1.43	2.55e-10	GO:0051246	regulation of protein metabolic process
1.23	2.63e-10	GO:0060255	regulation of macromolecule metabolic process
1.46	2.99e-10	GO:0042127	regulation of cell proliferation
1.22	5.83e-10	GO:0051179	localization
1.55	6.67e-10	GO:0009719	response to endogenous stimulus
1.27	7.96e-10	GO:0006950	response to stress
1.23	8.03e-10	GO:0048856	anatomical structure development
1.20	8.19e-10	GO:0032502	developmental process
1.21	9.63e-10	GO:0023052	signaling
1.22	1.11e-09	GO:0007165	signal transduction
1.34	1.13e-09	GO:0006996	organelle organization
1.21	1.95e-09	GO:0031323	regulation of cellular metabolic process
1.21	2.46e-09	GO:0080090	regulation of primary metabolic process
1.39	2.74e-09	GO:0044085	cellular component biogenesis
1.31	2.85e-09	GO:0006464	protein modification process
1.43	2.96e-09	GO:0032268	regulation of cellular protein metabolic process
1.28	3.54e-09	GO:0065008	regulation of biological quality
1.42	4.47e-09	GO:0022607	cellular component assembly
1.33	4.62e-09	GO:0023051	regulation of signaling
1.35	4.74e-09	GO:0009966	regulation of signal transduction
1.32	6.64e-09	GO:0009059	macromolecule biosynthetic process
1.32	7.00e-09	GO:0034645	cellular macromolecule biosynthetic process
1.50	8.75e-09	GO:0012501	programmed cell death
1.54	1.69e-08	GO:0009725	response to hormone stimulus
1.53	1.87e-08	GO:0051726	regulation of cell cycle
1.29	2.07e-08	GO:0043412	macromolecule modification
1.29	2.55e-08	GO:0010467	gene expression
1.46	3.15e-08	GO:0022402	cell cycle process
1.55	3.18e-08	GO:0000278	mitotic cell cycle
1.45	3.22e-08	GO:0033554	cellular response to stress
1.44	3.53e-08	GO:0008219	cell death
1.44	3.82e-08	GO:0016265	death
1.35	5.55e-08	GO:0033036	macromolecule localization
1.49	5.59e-08	GO:0006915	apoptosis
1.13	6.17e-08	GO:0050896	response to stimulus
1.51	6.21e-08	GO:0007167	enzyme linked receptor protein signaling pathway
1.33	6.31e-08	GO:0065009	regulation of molecular function
1.59	9.30e-08	GO:0070271	protein complex biogenesis
1.22	1.04e-07	GO:0048731	system development
1.49	1.10e-07	GO:0022403	cell cycle phase
1.32	1.37e-07	GO:0009653	anatomical structure morphogenesis
1.29	1.52e-07	GO:0044281	small molecule metabolic process
1.58	1.98e-07	GO:0006461	protein complex assembly
1.74	2.65e-07	GO:0006366	transcription from RNA polymerase II promoter
1.21	3.78e-07	GO:0051234	establishment of localization
1.27	3.90e-07	GO:0048583	regulation of response to stimulus
1.44	3.98e-07	GO:0031399	regulation of protein modification process
1.21	4.71e-07	GO:0006810	transport
1.47	5.55e-07	GO:0065003	macromolecular complex assembly
1.35	9.54e-07	GO:0050790	regulation of catalytic activity
1.42	1.04e-06	GO:0043933	macromolecular complex subunit organization
1.36	1.28e-06	GO:0010646	regulation of cell communication
1.47	1.28e-06	GO:0046483	heterocycle metabolic process
1.30	1.33e-06	GO:0007399	nervous system development
1.49	1.36e-06	GO:0009057	macromolecule catabolic process
1.53	2.09e-06	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.51	2.20e-06	GO:0055086	nucleobase, nucleoside and nucleotide metabolic process
1.66	2.23e-06	GO:0043434	response to peptide hormone stimulus
1.63	2.41e-06	GO:0044419	interspecies interaction between organisms
1.18	2.43e-06	GO:0007275	multicellular organismal development
1.49	2.94e-06	GO:0071822	protein complex subunit organization
1.68	4.47e-06	GO:0051325	interphase
1.52	4.52e-06	GO:0006753	nucleoside phosphate metabolic process
1.52	4.52e-06	GO:0009117	nucleotide metabolic process
1.49	4.95e-06	GO:0050878	regulation of body fluid levels
1.68	6.28e-06	GO:0051329	interphase of mitotic cell cycle
1.40	1.02e-05	GO:0051128	regulation of cellular component organization
1.34	1.11e-05	GO:0008104	protein localization
1.55	1.18e-05	GO:0072521	purine-containing compound metabolic process
1.57	1.18e-05	GO:0051247	positive regulation of protein metabolic process
1.38	1.37e-05	GO:0045184	establishment of protein localization
1.43	1.51e-05	GO:0019220	regulation of phosphate metabolic process
1.43	1.51e-05	GO:0051174	regulation of phosphorus metabolic process
1.38	1.55e-05	GO:0009891	positive regulation of biosynthetic process
1.49	2.02e-05	GO:0044265	cellular macromolecule catabolic process
1.41	2.05e-05	GO:0016192	vesicle-mediated transport
1.38	2.31e-05	GO:0015031	protein transport
1.36	3.11e-05	GO:0022008	neurogenesis
1.50	3.55e-05	GO:0007599	hemostasis
1.61	3.60e-05	GO:0071495	cellular response to endogenous stimulus
1.47	4.74e-05	GO:0016071	mRNA metabolic process
1.37	4.81e-05	GO:0031328	positive regulation of cellular biosynthetic process
1.63	5.44e-05	GO:0032870	cellular response to hormone stimulus
1.43	5.59e-05	GO:0030030	cell projection organization
1.41	6.83e-05	GO:0042325	regulation of phosphorylation
1.49	6.94e-05	GO:0007596	blood coagulation
1.49	6.94e-05	GO:0050817	coagulation
1.22	7.78e-05	GO:0048869	cellular developmental process
1.55	8.16e-05	GO:0032270	positive regulation of cellular protein metabolic process
1.72	8.25e-05	GO:0032868	response to insulin stimulus
1.34	8.31e-05	GO:0009892	negative regulation of metabolic process
1.36	9.39e-05	GO:0006351	transcription, DNA-dependent
1.91	9.74e-05	GO:0000082	G1/S transition of mitotic cell cycle
1.44	1.12e-04	GO:0042060	wound healing
1.47	1.22e-04	GO:0010942	positive regulation of cell death
1.80	1.29e-04	GO:0032869	cellular response to insulin stimulus
1.58	1.47e-04	GO:0009259	ribonucleotide metabolic process
1.42	1.49e-04	GO:0001932	regulation of protein phosphorylation
1.64	1.68e-04	GO:0007346	regulation of mitotic cell cycle
1.46	1.80e-04	GO:0043068	positive regulation of programmed cell death
1.46	1.83e-04	GO:0008284	positive regulation of cell proliferation
1.46	1.94e-04	GO:0043065	positive regulation of apoptosis
1.71	1.94e-04	GO:0071375	cellular response to peptide hormone stimulus
1.65	1.97e-04	GO:0009166	nucleotide catabolic process
1.43	2.22e-04	GO:0006259	DNA metabolic process
1.27	2.24e-04	GO:0035556	intracellular signal transduction
1.59	2.33e-04	GO:0009150	purine ribonucleotide metabolic process
1.22	2.49e-04	GO:0030154	cell differentiation
1.37	2.87e-04	GO:0051173	positive regulation of nitrogen compound metabolic process
1.35	3.00e-04	GO:0048699	generation of neurons
1.37	3.09e-04	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45	3.19e-04	GO:0070727	cellular macromolecule localization
1.52	3.32e-04	GO:0006163	purine nucleotide metabolic process
1.45	3.44e-04	GO:0034613	cellular protein localization
1.89	3.57e-04	GO:0008286	insulin receptor signaling pathway
1.35	3.94e-04	GO:0044093	positive regulation of molecular function
1.46	4.23e-04	GO:0043549	regulation of kinase activity
1.40	4.36e-04	GO:0071310	cellular response to organic substance
1.37	4.43e-04	GO:0071844	cellular component assembly at cellular level
1.32	4.53e-04	GO:0032774	RNA biosynthetic process
1.54	4.56e-04	GO:0051301	cell division
1.58	4.85e-04	GO:0009141	nucleoside triphosphate metabolic process
1.40	6.40e-04	GO:0032989	cellular component morphogenesis
1.33	6.59e-04	GO:0048468	cell development
1.36	6.69e-04	GO:0010557	positive regulation of macromolecule biosynthetic process
1.33	6.83e-04	GO:0010605	negative regulation of macromolecule metabolic process
1.45	6.90e-04	GO:0048858	cell projection morphogenesis
1.44	7.49e-04	GO:0032990	cell part morphogenesis
1.31	7.88e-04	GO:0009605	response to external stimulus
1.46	7.90e-04	GO:0009628	response to abiotic stimulus
1.44	8.13e-04	GO:0006974	response to DNA damage stimulus
1.43	8.14e-04	GO:0044282	small molecule catabolic process
1.38	8.70e-04	GO:0045595	regulation of cell differentiation
1.44	1.01e-03	GO:0031175	neuron projection development
1.50	1.05e-03	GO:0006886	intracellular protein transport
1.30	1.12e-03	GO:0006793	phosphorus metabolic process
1.30	1.12e-03	GO:0006796	phosphate metabolic process
1.57	1.17e-03	GO:0009199	ribonucleoside triphosphate metabolic process
1.47	1.19e-03	GO:0043066	negative regulation of apoptosis
1.47	1.30e-03	GO:0043069	negative regulation of programmed cell death
1.52	1.45e-03	GO:0010564	regulation of cell cycle process
1.63	1.53e-03	GO:0006195	purine nucleotide catabolic process
1.37	1.54e-03	GO:0051254	positive regulation of RNA metabolic process
1.32	1.57e-03	GO:0050793	regulation of developmental process
1.40	1.59e-03	GO:0000902	cell morphogenesis
1.46	1.69e-03	GO:0060548	negative regulation of cell death
1.43	1.74e-03	GO:0051338	regulation of transferase activity
1.56	1.75e-03	GO:0009144	purine nucleoside triphosphate metabolic process
1.56	1.87e-03	GO:0009205	purine ribonucleoside triphosphate metabolic process
1.44	2.02e-03	GO:0045859	regulation of protein kinase activity
1.55	2.12e-03	GO:0044270	cellular nitrogen compound catabolic process
1.26	2.28e-03	GO:0051239	regulation of multicellular organismal process
1.43	2.36e-03	GO:0009967	positive regulation of signal transduction
1.57	2.43e-03	GO:0034655	nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.57	2.43e-03	GO:0034656	nucleobase, nucleoside and nucleotide catabolic process
1.56	2.61e-03	GO:0051270	regulation of cellular component movement
1.46	2.63e-03	GO:0008285	negative regulation of cell proliferation
1.61	2.81e-03	GO:0072523	purine-containing compound catabolic process
1.45	2.92e-03	GO:0048812	neuron projection morphogenesis
1.17	3.09e-03	GO:0009889	regulation of biosynthetic process
1.45	3.17e-03	GO:0016044	cellular membrane organization
1.30	3.22e-03	GO:0070887	cellular response to chemical stimulus
1.63	3.38e-03	GO:0048011	nerve growth factor receptor signaling pathway
1.44	3.45e-03	GO:0048646	anatomical structure formation involved in morphogenesis
1.29	3.85e-03	GO:0032879	regulation of localization
1.46	3.87e-03	GO:0016032	viral reproduction
1.46	3.87e-03	GO:0016477	cell migration
1.44	4.33e-03	GO:0061024	membrane organization
1.49	4.39e-03	GO:0016568	chromatin modification
1.30	4.39e-03	GO:0031324	negative regulation of cellular metabolic process
1.55	4.71e-03	GO:0042493	response to drug
1.44	5.02e-03	GO:0048667	cell morphogenesis involved in neuron differentiation
1.74	5.02e-03	GO:0071496	cellular response to external stimulus
1.56	5.07e-03	GO:0010035	response to inorganic substance
1.62	5.61e-03	GO:0051259	protein oligomerization
1.39	5.68e-03	GO:0006928	cellular component movement
1.45	5.80e-03	GO:0043086	negative regulation of catalytic activity
1.51	5.93e-03	GO:0007411	axon guidance
1.91	6.38e-03	GO:0010720	positive regulation of cell development
1.36	6.64e-03	GO:0006396	RNA processing
1.49	6.99e-03	GO:0006917	induction of apoptosis
1.31	7.85e-03	GO:0048584	positive regulation of response to stimulus
1.30	8.04e-03	GO:0009611	response to wounding
1.38	8.21e-03	GO:0048666	neuron development
1.48	8.30e-03	GO:0012502	induction of programmed cell death
1.16	8.62e-03	GO:0031326	regulation of cellular biosynthetic process
1.56	8.62e-03	GO:2000145	regulation of cell motility
1.39	9.13e-03	GO:0044092	negative regulation of molecular function
1.41	9.14e-03	GO:0072358	cardiovascular system development
1.41	9.14e-03	GO:0072359	circulatory system development
1.56	9.21e-03	GO:0030334	regulation of cell migration
1.54	9.75e-03	GO:0051960	regulation of nervous system development
1.51	9.78e-03	GO:0031401	positive regulation of protein modification process
1.61	9.83e-03	GO:0045786	negative regulation of cell cycle
1.28	1.08e-02	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.71	1.11e-02	GO:0031400	negative regulation of protein modification process
2.10	1.14e-02	GO:0006921	cellular component disassembly involved in apoptosis
1.53	1.16e-02	GO:0030029	actin filament-based process
1.57	1.20e-02	GO:0050767	regulation of neurogenesis
1.50	1.21e-02	GO:0060284	regulation of cell development
1.59	1.26e-02	GO:0051129	negative regulation of cellular component organization
1.16	1.44e-02	GO:0010468	regulation of gene expression
1.52	1.50e-02	GO:0040012	regulation of locomotion
1.57	1.57e-02	GO:0032269	negative regulation of cellular protein metabolic process
1.55	1.57e-02	GO:0051248	negative regulation of protein metabolic process
1.29	1.57e-02	GO:0040011	locomotion
1.45	1.66e-02	GO:0044271	cellular nitrogen compound biosynthetic process
1.59	1.76e-02	GO:0071156	regulation of cell cycle arrest
1.16	1.83e-02	GO:0010556	regulation of macromolecule biosynthetic process
1.54	1.88e-02	GO:0001568	blood vessel development
1.35	1.91e-02	GO:0051276	chromosome organization
1.33	1.95e-02	GO:0010628	positive regulation of gene expression
1.99	2.08e-02	GO:0008629	induction of apoptosis by intracellular signals
1.78	2.13e-02	GO:0051789	response to protein stimulus
1.49	2.31e-02	GO:0046700	heterocycle catabolic process
1.42	2.48e-02	GO:0007409	axonogenesis
1.15	2.49e-02	GO:0051171	regulation of nitrogen compound metabolic process
1.51	2.49e-02	GO:0071900	regulation of protein serine/threonine kinase activity
1.16	2.49e-02	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.48	2.62e-02	GO:0006511	ubiquitin-dependent protein catabolic process
1.51	2.67e-02	GO:0032446	protein modification by small protein conjugation
1.37	2.88e-02	GO:0023056	positive regulation of signaling
1.37	3.11e-02	GO:0010647	positive regulation of cell communication
1.95	3.11e-02	GO:0051656	establishment of organelle localization
1.55	3.26e-02	GO:0018130	heterocycle biosynthetic process
1.51	3.44e-02	GO:0010608	posttranscriptional regulation of gene expression
1.57	3.48e-02	GO:0009261	ribonucleotide catabolic process
1.18	3.54e-02	GO:0048513	organ development
1.40	4.06e-02	GO:0000279	M phase
1.46	4.09e-02	GO:0045597	positive regulation of cell differentiation
1.48	4.17e-02	GO:0008380	RNA splicing
1.53	4.18e-02	GO:0030036	actin cytoskeleton organization
1.56	4.55e-02	GO:0009143	nucleoside triphosphate catabolic process
1.56	4.55e-02	GO:0009154	purine ribonucleotide catabolic process
1.46	4.75e-02	GO:0033043	regulation of organelle organization
1.33	4.76e-02	GO:0045893	positive regulation of transcription, DNA-dependent
1.46	4.81e-02	GO:0051603	proteolysis involved in cellular protein catabolic process
1.56	4.87e-02	GO:0009146	purine nucleoside triphosphate catabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.19	8.10e-73	GO:0044424	intracellular part
1.17	1.68e-68	GO:0005622	intracellular
1.26	7.91e-66	GO:0005737	cytoplasm
1.32	9.11e-54	GO:0044444	cytoplasmic part
1.19	3.11e-51	GO:0043229	intracellular organelle
1.19	4.63e-51	GO:0043226	organelle
1.21	3.59e-49	GO:0043227	membrane-bounded organelle
1.21	1.01e-48	GO:0043231	intracellular membrane-bounded organelle
1.60	1.02e-47	GO:0005829	cytosol
1.29	5.08e-39	GO:0044446	intracellular organelle part
1.28	9.06e-39	GO:0044422	organelle part
1.47	5.99e-31	GO:0044428	nuclear part
1.45	2.13e-30	GO:0031974	membrane-enclosed lumen
1.45	8.96e-30	GO:0070013	intracellular organelle lumen
1.45	1.47e-29	GO:0043233	organelle lumen
1.24	3.28e-26	GO:0005634	nucleus
1.48	6.57e-26	GO:0031981	nuclear lumen
1.51	4.18e-20	GO:0005654	nucleoplasm
1.28	2.91e-19	GO:0032991	macromolecular complex
1.05	3.30e-19	GO:0044464	cell part
1.05	3.69e-19	GO:0005623	cell
1.29	2.30e-17	GO:0043234	protein complex
1.29	1.27e-10	GO:0031090	organelle membrane
1.50	9.47e-10	GO:0031975	envelope
1.50	1.28e-09	GO:0031967	organelle envelope
1.70	4.21e-09	GO:0048471	perinuclear region of cytoplasm
1.47	1.29e-08	GO:0044451	nucleoplasm part
1.22	2.35e-08	GO:0043228	non-membrane-bounded organelle
1.22	2.35e-08	GO:0043232	intracellular non-membrane-bounded organelle
1.37	2.64e-08	GO:0000267	cell fraction
1.29	7.88e-08	GO:0012505	endomembrane system
1.67	1.07e-07	GO:0005625	soluble fraction
1.30	8.71e-07	GO:0005739	mitochondrion
1.74	1.42e-06	GO:0005635	nuclear envelope
2.22	2.31e-06	GO:0042470	melanosome
2.22	2.31e-06	GO:0048770	pigment granule
1.59	5.67e-05	GO:0015629	actin cytoskeleton
1.37	1.01e-04	GO:0044429	mitochondrial part
1.90	1.04e-04	GO:0019867	outer membrane
1.30	2.60e-04	GO:0005794	Golgi apparatus
1.79	4.79e-04	GO:0031965	nuclear membrane
1.86	5.27e-04	GO:0031968	organelle outer membrane
1.75	7.97e-04	GO:0005912	adherens junction
1.71	8.61e-04	GO:0070161	anchoring junction
2.67	9.44e-04	GO:0042641	actomyosin
1.34	9.86e-04	GO:0015630	microtubule cytoskeleton
1.37	1.52e-03	GO:0005694	chromosome
2.14	4.39e-03	GO:0030496	midbody
2.70	4.45e-03	GO:0001725	stress fiber
1.25	4.77e-03	GO:0005783	endoplasmic reticulum
1.39	4.98e-03	GO:0005740	mitochondrial envelope
1.89	5.03e-03	GO:0016585	chromatin remodeling complex
1.85	5.04e-03	GO:0005741	mitochondrial outer membrane
1.56	6.99e-03	GO:0000228	nuclear chromosome
1.20	7.61e-03	GO:0005856	cytoskeleton
1.79	8.98e-03	GO:0030055	cell-substrate junction
1.27	9.78e-03	GO:0005626	insoluble fraction
1.38	1.11e-02	GO:0031966	mitochondrial membrane
3.04	1.40e-02	GO:0030530	heterogeneous nuclear ribonucleoprotein complex
1.78	1.68e-02	GO:0005924	cell-substrate adherens junction
2.52	1.77e-02	GO:0032432	actin filament bundle
1.23	2.01e-02	GO:0044430	cytoskeletal part
1.26	2.23e-02	GO:0005624	membrane fraction
1.78	2.36e-02	GO:0005925	focal adhesion
1.34	2.53e-02	GO:0005730	nucleolus
1.33	2.56e-02	GO:0030529	ribonucleoprotein complex
2.20	2.99e-02	GO:0017053	transcriptional repressor complex
1.63	3.66e-02	GO:0000775	chromosome, centromeric region
2.97	4.29e-02	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
1.34	4.36e-02	GO:0044427	chromosomal part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.32	5.43e-79	GO:0005515	protein binding
1.14	6.70e-47	GO:0005488	binding
1.17	3.30e-12	GO:0003824	catalytic activity
1.27	2.90e-10	GO:0000166	nucleotide binding
1.49	1.32e-09	GO:0042802	identical protein binding
1.45	3.29e-08	GO:0019899	enzyme binding
1.25	5.34e-07	GO:0032553	ribonucleotide binding
1.25	5.34e-07	GO:0032555	purine ribonucleotide binding
1.25	9.49e-07	GO:0017076	purine nucleotide binding
1.25	1.22e-06	GO:0035639	purine ribonucleoside triphosphate binding
1.54	1.96e-06	GO:0019904	protein domain specific binding
1.58	2.98e-06	GO:0000988	protein binding transcription factor activity
1.58	2.98e-06	GO:0000989	transcription factor binding transcription factor activity
1.57	4.78e-06	GO:0003712	transcription cofactor activity
1.25	3.72e-05	GO:0032559	adenyl ribonucleotide binding
1.40	4.68e-05	GO:0046983	protein dimerization activity
1.25	5.45e-05	GO:0030554	adenyl nucleotide binding
1.48	1.08e-04	GO:0042803	protein homodimerization activity
1.24	1.54e-04	GO:0005524	ATP binding
1.33	2.29e-04	GO:0003723	RNA binding
1.63	8.18e-04	GO:0003713	transcription coactivator activity
1.97	8.19e-03	GO:0031625	ubiquitin protein ligase binding
1.65	1.38e-02	GO:0004721	phosphoprotein phosphatase activity
1.26	1.41e-02	GO:0016772	transferase activity, transferring phosphorus-containing groups
1.47	1.59e-02	GO:0008134	transcription factor binding
1.46	1.74e-02	GO:0016879	ligase activity, forming carbon-nitrogen bonds
1.27	3.57e-02	GO:0016817	hydrolase activity, acting on acid anhydrides
1.27	3.74e-02	GO:0016301	kinase activity
1.41	3.83e-02	GO:0042578	phosphoric ester hydrolase activity
1.27	3.83e-02	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.27	4.11e-02	GO:0016462	pyrophosphatase activity
1.78	4.17e-02	GO:0051427	hormone receptor binding
1.28	4.22e-02	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.32	4.78e-02	GO:0008092	cytoskeletal protein binding