Motif ID: PPARG.p2

Z-value: 1.730


Transcription factors associated with PPARG.p2:

Gene SymbolEntrez IDGene Name
PPARG 5468 peroxisome proliferator-activated receptor gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PPARGchr3_+_12392993,
chr3_+_12330336
0.072.9e-01Click!


Activity profile for motif PPARG.p2.

activity profile for motif PPARG.p2


Sorted Z-values histogram for motif PPARG.p2

Sorted Z-values for motif PPARG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PPARG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_22758538 79.862


chr14_-_106208695 47.326


chr19_+_50016606 39.964 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr22_+_23229959 30.107 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr9_-_33447527 29.680 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr1_-_31230594 24.821 LAPTM5
lysosomal protein transmembrane 5
chr10_+_114135937 22.634 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_31230673 19.821 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr14_+_105953256 19.257 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr10_+_114135965 19.038 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_203274646 17.809 NM_006763
BTG2
BTG family, member 2
chr10_+_114136014 17.562 ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_-_62097937 17.143 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr10_-_72362513 13.728 NM_001083116
NM_005041
PRF1

perforin 1 (pore forming protein)

chr19_+_7968765 13.601 MAP2K7
mitogen-activated protein kinase kinase 7
chr11_+_313852 13.316 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr19_+_7968762 12.703 MAP2K7
mitogen-activated protein kinase kinase 7
chr14_+_24630421 12.500 NM_006084
IRF9
interferon regulatory factor 9
chr19_+_50016435 11.284 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_-_106208537 11.115


chr19_+_7968701 11.045 MAP2K7
mitogen-activated protein kinase kinase 7
chr22_+_22550112 10.851


chr19_+_7968764 10.816 NM_145185
MAP2K7
mitogen-activated protein kinase kinase 7
chrX_-_107019001 9.540 NM_198057
TSC22D3
TSC22 domain family, member 3
chr19_+_50016500 9.522 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_7968820 9.426 MAP2K7
mitogen-activated protein kinase kinase 7
chr17_+_25958192 8.994 LGALS9
lectin, galactoside-binding, soluble, 9
chr22_+_23154240 8.913


chr10_-_99052429 8.649 NM_001204300
NM_032900
ARHGAP19

Rho GTPase activating protein 19

chr7_+_75932865 8.329 HSPB1
heat shock 27kDa protein 1
chr11_+_308106 8.041 NM_006435
IFITM2
interferon induced transmembrane protein 2 (1-8D)
chr7_+_75932992 7.912 HSPB1
heat shock 27kDa protein 1
chr19_+_7968774 7.721 MAP2K7
mitogen-activated protein kinase kinase 7
chr11_+_75526211 7.417 NM_003369
UVRAG
UV radiation resistance associated gene
chr5_+_178977559 7.152 NM_025158
RUFY1
RUN and FYVE domain containing 1
chr12_-_6484904 6.946 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr10_-_99052391 6.794 ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 readthrough
Rho GTPase activating protein 19
chr11_+_75526236 6.678 UVRAG
UV radiation resistance associated gene
chr7_+_30951414 6.495 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chrX_-_107018889 6.460 TSC22D3
TSC22 domain family, member 3
chr10_-_99052358 6.377 ARHGAP19
Rho GTPase activating protein 19
chr19_+_49660997 6.342 NM_001195227
NM_017636
TRPM4

transient receptor potential cation channel, subfamily M, member 4

chr1_+_207925381 6.337 NM_002389
NM_153826
NM_172350
NM_172351
NM_172352
NM_172353
NM_172359
NM_172361
CD46







CD46 molecule, complement regulatory protein







chr10_-_116418056 6.304 NM_002313
ABLIM1
actin binding LIM protein 1
chr11_+_46740736 6.229 NM_000506
F2
coagulation factor II (thrombin)
chr11_+_46740769 6.187 F2
coagulation factor II (thrombin)
chr12_-_53600999 6.137 NM_000889
ITGB7
integrin, beta 7
chr22_+_22676814 6.083


chr19_-_13213669 5.966 LYL1
lymphoblastic leukemia derived sequence 1
chr8_-_70745403 5.902 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr15_-_90347173 5.519 ANPEP
alanyl (membrane) aminopeptidase
chr11_+_117070039 5.492 NM_001001522
NM_003186
TAGLN

transgelin

chr15_-_90347534 5.405 ANPEP
alanyl (membrane) aminopeptidase
chr11_-_59952138 5.399 NM_001247999
NM_152852
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr22_-_36019363 5.311 NM_203377
MB
myoglobin
chr2_+_219283809 5.272 NM_007127
VIL1
villin 1
chr13_+_49794471 5.265 NM_001507
MLNR
motilin receptor
chr3_+_33840077 5.264 PDCD6IP
programmed cell death 6 interacting protein
chr1_-_159895279 5.142 NM_003564
TAGLN2
transgelin 2
chr13_-_73355969 4.991 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr22_+_23165273 4.951


chr19_+_42388445 4.928 NM_199002
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr17_-_34207308 4.879 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr17_+_25958151 4.826 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr19_+_50016490 4.812 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_57504935 4.795 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_-_67771527 4.610 NM_030930
UNC93B1
unc-93 homolog B1 (C. elegans)
chr11_+_2923559 4.587 SLC22A18
solute carrier family 22, member 18
chr3_+_33840093 4.582 PDCD6IP
programmed cell death 6 interacting protein
chr4_+_87856152 4.387 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr22_-_36784001 4.274 MYH9
myosin, heavy chain 9, non-muscle
chr3_-_46505077 4.198 NM_001199149
LTF
lactotransferrin
chr11_+_2923528 4.174 SLC22A18
solute carrier family 22, member 18
chr3_+_33840060 4.121 NM_001162429
NM_013374
PDCD6IP

programmed cell death 6 interacting protein

chr1_+_207925409 4.102 CD46
CD46 molecule, complement regulatory protein
chr3_+_8775485 4.064 NM_001234
NM_033337
CAV3

caveolin 3

chr1_-_236228382 4.058 NID1
nidogen 1
chr3_+_33840123 3.815 PDCD6IP
programmed cell death 6 interacting protein
chr22_+_50312333 3.789 CRELD2
cysteine-rich with EGF-like domains 2
chr22_+_50312278 3.700 NM_001135101
NM_024324
CRELD2

cysteine-rich with EGF-like domains 2

chr11_-_5255712 3.635 NM_000519
HBD
hemoglobin, delta
chr15_+_81517639 3.589 NM_172217
IL16
interleukin 16
chr1_-_151762905 3.577 NM_001083963
NM_001083964
NM_001083965
NM_006862
TDRKH



tudor and KH domain containing



chr22_-_36783851 3.549 MYH9
myosin, heavy chain 9, non-muscle
chr19_+_49661031 3.517 TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr14_-_106610338 3.391 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_-_72362441 3.358 PRF1
perforin 1 (pore forming protein)
chr22_-_36783977 3.309 MYH9
myosin, heavy chain 9, non-muscle
chr17_+_25958257 3.271 LGALS9
lectin, galactoside-binding, soluble, 9
chr12_-_46384365 3.208 NM_004719
SCAF11
SR-related CTD-associated factor 11
chr13_-_73356058 3.135 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr9_+_101984558 3.060 NM_006808
SEC61B
Sec61 beta subunit
chr16_-_4466961 2.935 NM_001201479
NM_001201472
NM_001201473
NM_024535
CORO7-PAM16
CORO7


CORO7-PAM16 readthrough
coronin 7


chr1_-_159895258 2.933 TAGLN2
transgelin 2
chr14_-_106994001 2.788 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr6_+_6588933 2.767 NM_004271
LY86
lymphocyte antigen 86
chr12_-_46384317 2.752 SCAF11
SR-related CTD-associated factor 11
chr19_+_18451365 2.535 NM_017712
PGPEP1
pyroglutamyl-peptidase I
chr1_+_153388999 2.529 NM_176823
S100A7A
S100 calcium binding protein A7A
chr14_-_106453162 2.507 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_-_5870546 2.499 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr9_-_130679210 2.482 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr22_-_24096551 2.470 NM_013378
VPREB3
pre-B lymphocyte 3
chr16_+_82068958 2.429 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr15_+_57998853 2.417 NM_001018102
NM_015532
POLR2M

polymerase (RNA) II (DNA directed) polypeptide M

chr17_+_45286713 2.413 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr14_-_106691698 2.378


chr22_+_22550159 2.326 IGLV6-57
immunoglobulin lambda variable 6-57
chr6_+_7108864 2.310 RREB1
ras responsive element binding protein 1
chr11_-_320775 2.301 NM_021034
IFITM3
interferon induced transmembrane protein 3
chr11_-_1330680 2.286 TOLLIP
toll interacting protein
chr19_+_3506264 2.278 NM_016263
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr22_-_36784055 2.262 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr15_+_57998920 2.235 POLR2M
polymerase (RNA) II (DNA directed) polypeptide M
chr15_+_69745156 2.233 NM_001003
NM_213725
RPLP1

ribosomal protein, large, P1

chr17_-_38721701 2.219 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr10_+_49514652 2.204 MAPK8
mitogen-activated protein kinase 8
chr15_+_44580870 2.100 NM_138423
NM_177974
CASC4

cancer susceptibility candidate 4

chr17_-_39728304 1.974 NM_000226
KRT9
keratin 9
chr5_-_179050675 1.966 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr12_-_121476770 1.958 NM_003733
NM_198213
OASL

2'-5'-oligoadenylate synthetase-like

chr11_-_63933204 1.949 MACROD1
MACRO domain containing 1
chr6_+_292033 1.946 NM_020185
DUSP22
dual specificity phosphatase 22
chr12_-_11324129 1.845 PRH1-PRR4
TAS2R14
PRH1
PRH1-PRR4 readthrough
taste receptor, type 2, member 14
proline-rich protein HaeIII subfamily 1
chr16_-_4165702 1.710 ADCY9
adenylate cyclase 9
chr19_-_5839702 1.678 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr1_-_151118932 1.669 NM_001178061
NM_001178062
NM_030913
SEMA6C


sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C


chr1_-_236228374 1.646 NID1
nidogen 1
chr17_+_80709913 1.604 NM_005993
TBCD
tubulin folding cofactor D
chr1_-_47407094 1.538 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr12_-_46384346 1.535 SCAF11
SR-related CTD-associated factor 11
chr7_-_100425035 1.517 NM_004444
EPHB4
EPH receptor B4
chr1_-_120311466 1.495 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr15_-_74658498 1.489 NM_001099773
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr3_-_196014583 1.485 NM_005017
PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr5_-_179050635 1.477 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr16_-_21663962 1.469 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chr17_-_7297826 1.468 PLSCR3
phospholipid scramblase 3
chr11_+_14665396 1.466 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr1_-_111970354 1.437 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr11_+_14665338 1.415 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr1_+_46016524 1.399 AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr10_+_74870209 1.398 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr16_+_19467771 1.389 NM_024780
TMC5
transmembrane channel-like 5
chr11_+_2923487 1.381 NM_002555
SLC22A18
solute carrier family 22, member 18
chr13_+_33160610 1.359 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr1_+_207495070 1.358 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr16_-_4466570 1.357 CORO7-PAM16
CORO7
CORO7-PAM16 readthrough
coronin 7
chr22_+_27017927 1.356 NM_001886
CRYBA4
crystallin, beta A4
chr19_+_49669404 1.355 TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr11_+_71900601 1.337 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr17_-_8093492 1.320 NM_017622
C17orf59
chromosome 17 open reading frame 59
chrX_-_118827060 1.277 SEPT6
septin 6
chr5_+_21459633 1.274 GUSBP1
glucuronidase, beta pseudogene 1
chr16_+_29831755 1.246 MVP
major vault protein
chr1_-_67896081 1.239 SERBP1
SERPINE1 mRNA binding protein 1
chr17_-_8815799 1.231 NM_014308
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr13_+_33160537 1.224 NM_015032
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr11_+_14665308 1.221 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr5_+_175223519 1.183 NM_006650
CPLX2
complexin 2
chr19_-_54746599 1.175 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr17_-_8093346 1.157 C17orf59
chromosome 17 open reading frame 59
chr11_+_117947785 1.143 TMPRSS4
transmembrane protease, serine 4
chr11_+_14665268 1.140 NM_000922
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr22_+_20008633 1.138 C22orf25
chromosome 22 open reading frame 25
chr4_+_110481315 1.135 NM_017918
CCDC109B
coiled-coil domain containing 109B
chr19_-_51587466 1.128 NM_022046
KLK14
kallikrein-related peptidase 14
chr20_-_34195409 1.123 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr9_-_136150629 1.120 NM_020469
ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr3_-_122512526 1.088 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr16_-_4466595 1.080 CORO7
coronin 7
chr8_-_145701717 1.069 NM_003923
FOXH1
forkhead box H1
chr3_+_48507209 1.044 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr15_+_44580954 1.029 CASC4
cancer susceptibility candidate 4
chr8_+_133879202 1.012 NM_003235
TG
thyroglobulin
chr16_-_4466607 0.988 CORO7
coronin 7
chr9_+_139981338 0.985 MAN1B1
mannosidase, alpha, class 1B, member 1
chr12_-_96390002 0.977 NM_002108
HAL
histidine ammonia-lyase
chr16_+_55512801 0.976 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_+_27301434 0.964 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr1_+_150521786 0.953 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr18_+_29671817 0.950 NM_016271
RNF138
ring finger protein 138
chrX_+_105937067 0.926 NM_024539
RNF128
ring finger protein 128
chr5_-_180076616 0.919 NM_002020
NM_182925
FLT4

fms-related tyrosine kinase 4

chr19_+_589849 0.913 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr17_-_38074842 0.910 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr11_+_117947726 0.906 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr11_+_394238 0.903 PKP3
plakophilin 3
chr5_-_1494872 0.885 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr9_-_139094886 0.884 NM_014564
LHX3
LIM homeobox 3
chr17_+_46908371 0.879 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr1_-_6526150 0.860 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr7_-_27192201 0.855


chr11_+_76494132 0.854 NM_015516
TSKU
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr11_+_63706433 0.830 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr1_-_160832466 0.821 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr19_-_45826131 0.812 CKM
creatine kinase, muscle
chr18_-_77793914 0.809


chr12_+_109915461 0.808 UBE3B
ubiquitin protein ligase E3B
chr17_+_54911452 0.808 NM_003647
DGKE
diacylglycerol kinase, epsilon 64kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.74 3.55e-06 GO:0002376 immune system process
3.28 1.17e-05 GO:0006955 immune response
2.58 4.76e-03 GO:0051704 multi-organism process
1.87 7.88e-03 GO:0042221 response to chemical stimulus
1.98 1.13e-02 GO:0007166 cell surface receptor linked signaling pathway
3.47 1.84e-02 GO:0045087 innate immune response
2.16 2.70e-02 GO:0010033 response to organic substance
1.40 2.80e-02 GO:0050896 response to stimulus
2.68 4.52e-02 GO:0071310 cellular response to organic substance

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.72 1.29e-03 GO:0005625 soluble fraction
2.30 1.70e-03 GO:0000267 cell fraction
2.19 2.48e-03 GO:0005887 integral to plasma membrane
1.83 2.92e-03 GO:0044459 plasma membrane part
2.15 3.67e-03 GO:0031226 intrinsic to plasma membrane
1.45 4.28e-02 GO:0071944 cell periphery
1.45 4.64e-02 GO:0005886 plasma membrane

Nothing significant found in function category.