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• Activity deltas table
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Motif ID: PRDM1.p3

Z-value: 1.628

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_+_32821924	33.126	NM_002800	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr14_+_24605366	28.001	NM_006263 NM_176783	PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_+_24605393	25.340		PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr16_-_67970734	24.079	NM_002801	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr1_-_111746917	23.945		DENND2D	DENN/MADD domain containing 2D
chr16_-_67970651	19.706		PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr11_+_63304272	18.779	NM_004585	RARRES3	retinoic acid receptor responder (tazarotene induced) 3
chr12_+_25205180	16.582	NM_001204126 NM_001204127 NM_006152	LRMP	lymphoid-restricted membrane protein
chrX_-_118827060	16.235		SEPT6	septin 6
chr6_-_32811773	16.184	NM_148919	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chrX_-_118827322	15.257	NM_015129 NM_145799 NM_145800 NM_145802	SEPT6	septin 6
chr2_-_231084600	14.627	NM_004509 NM_004510 NM_080424	SP110	SP110 nuclear body protein
chr1_+_212781969	14.605	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr3_-_49851217	14.138		UBA7	ubiquitin-like modifier activating enzyme 7
chr6_-_33282006	13.843	NM_003190 NM_172208 NM_172209	TAPBP	TAP binding protein (tapasin)
chr5_+_96212167	13.379		ERAP2	endoplasmic reticulum aminopeptidase 2
chr5_-_142815076	13.357	NM_001018074 NM_001018075 NM_001018077	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_-_49851356	13.287	NM_003335	UBA7	ubiquitin-like modifier activating enzyme 7
chr14_-_69262959	12.836	NM_001244701	ZFP36L1	zinc finger protein 36, C3H type-like 1
chr2_+_231280906	12.365		SP100	SP100 nuclear antigen
chr12_-_57505176	11.970	NM_001178078 NM_001178080 NM_001178081 NM_003153	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced
chr20_+_388941	11.575		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr12_+_25205488	10.961		LRMP	lymphoid-restricted membrane protein
chr6_-_33281847	10.742		TAPBP	TAP binding protein (tapasin)
chr1_+_212782103	10.043		ATF3	activating transcription factor 3
chr17_-_48271365	9.955
chr20_+_388717	9.944		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr22_-_36556781	9.667	NM_145640	APOL3	apolipoprotein L, 3
chr2_-_152146373	8.622	NM_004688	NMI	N-myc (and STAT) interactor
chr6_-_31704272	8.617		CLIC1	chloride intracellular channel 1
chr12_+_6561176	8.536	NM_018009	TAPBPL	TAP binding protein-like
chr2_+_231191877	8.390	NM_138402	SP140L	SP140 nuclear body protein-like
chrX_-_118827155	8.332		SEPT6	septin 6
chr14_+_58711457	8.144	NM_002788 NM_152132	PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr8_+_144640476	8.078	NM_024736	GSDMD	gasdermin D
chr14_+_58711555	7.977		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr14_-_69259654	7.632		ZFP36L1	zinc finger protein 36, C3H type-like 1
chr19_+_49838700	7.409		CD37	CD37 molecule
chr12_-_57505121	6.947		STAT6	signal transducer and activator of transcription 6, interleukin-4 induced
chr13_-_110802708	6.931		COL4A1	collagen, type IV, alpha 1
chr4_-_186578122	6.705	NM_001145674 NM_001145675	SORBS2	sorbin and SH3 domain containing 2
chr6_-_32812189	6.680		PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr5_+_139889635	6.583
chr1_-_154580677	6.483	NM_001111 NM_015840 NM_015841	ADAR	adenosine deaminase, RNA-specific
chr17_+_6659155	6.148	NM_017523 NM_199139	XAF1	XIAP associated factor 1
chr10_-_44880452	6.120	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr14_-_24615794	5.981	NM_002818	PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr13_+_53216564	5.891		HNRNPA1L2	heterogeneous nuclear ribonucleoprotein A1-like 2
chr19_+_49977817	5.783	NM_001204503	FLT3LG	fms-related tyrosine kinase 3 ligand
chr9_-_16727887	5.748		BNC2	basonuclin 2
chr2_+_3627725	5.684		RPS7	ribosomal protein S7
chr1_-_148176392	5.678
chr1_-_144520918	5.624		LOC728855	uncharacterized LOC728855
chr9_+_137533643	5.607	NM_000093	COL5A1	collagen, type V, alpha 1
chr22_+_39473009	5.583	NM_021822	APOBEC3G	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr13_+_31309690	5.519		ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr7_-_86848818	5.513	NM_024315	C7orf23	chromosome 7 open reading frame 23
chr14_+_58711599	5.468		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr8_+_97506020	5.397		SDC2	syndecan 2
chr3_-_101405400	5.388	NM_000986	RPL24	ribosomal protein L24
chr19_+_49838734	5.332		CD37	CD37 molecule
chrX_-_118827116	5.241		SEPT6	septin 6
chr4_-_185395616	5.193	NM_002199	IRF2	interferon regulatory factor 2
chr19_+_49977465	5.011	NM_001204502 NM_001459	FLT3LG	fms-related tyrosine kinase 3 ligand
chr13_+_31309644	4.917	NM_001629	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr4_+_37892698	4.903	NM_015173	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr3_+_8543508	4.815	NM_014583	LMCD1	LIM and cysteine-rich domains 1
chr17_+_41158741	4.752	NM_005533	IFI35	interferon-induced protein 35
chr11_+_64008412	4.732	NM_004470	FKBP2	FK506 binding protein 2, 13kDa
chr11_+_65190272	4.726
chr10_+_63808968	4.595	NM_001244638	ARID5B	AT rich interactive domain 5B (MRF1-like)
chr6_-_29527701	4.523	NM_006398	UBD	ubiquitin D
chr1_-_154580632	4.405		ADAR	adenosine deaminase, RNA-specific
chr9_+_112542496	4.335	NM_053016 NM_007203 NM_147150	PALM2 PALM2-AKAP2	paralemmin 2 PALM2-AKAP2 readthrough
chr18_+_48405426	4.302	NM_001168335 NM_002396	ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial
chr6_+_26440699	4.290	NM_001242803 NM_006994 NM_197974	BTN3A3	butyrophilin, subfamily 3, member A3
chr6_-_29527477	4.274		UBD	ubiquitin D
chr8_+_97506071	4.211		SDC2	syndecan 2
chr4_-_186577858	3.876		SORBS2	sorbin and SH3 domain containing 2
chr12_-_57504935	3.824		STAT6	signal transducer and activator of transcription 6, interleukin-4 induced
chr2_-_190044330	3.820	NM_000393	COL5A2	collagen, type V, alpha 2
chr17_+_6659356	3.792		XAF1	XIAP associated factor 1
chr11_-_104839263	3.777	NM_001225	CASP4	caspase 4, apoptosis-related cysteine peptidase
chr1_-_144521169	3.770		FAM91A2	family with sequence similarity 91, member A2
chr11_-_58343308	3.766	NM_004811	LPXN	leupaxin
chr8_+_96145942	3.754	NM_024613	PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr18_-_53071225	3.721	NM_001243232	TCF4	transcription factor 4
chr4_+_152020732	3.695	NM_001006	RPS3A	ribosomal protein S3A
chr17_-_80407601	3.693	NM_001193655	C17orf62	chromosome 17 open reading frame 62
chr1_-_147931877	3.637		FLJ39739	uncharacterized FLJ39739
chr22_+_22550112	3.538
chr13_-_41635072	3.530		ELF1	E74-like factor 1 (ets domain transcription factor)
chr12_-_56709831	3.524	NM_001190991 NM_014255	CNPY2	canopy 2 homolog (zebrafish)
chr14_-_69260630	3.522	NM_001244698 NM_004926	ZFP36L1	zinc finger protein 36, C3H type-like 1
chr1_+_162602308	3.515		DDR2	discoidin domain receptor tyrosine kinase 2
chr1_+_19972259	3.447	NM_001204086	NBL1	neuroblastoma, suppression of tumorigenicity 1
chr5_+_49962920	3.412		PARP8	poly (ADP-ribose) polymerase family, member 8
chr2_+_202122753	3.409	NM_001080125	CASP8	caspase 8, apoptosis-related cysteine peptidase
chr14_-_24615772	3.341		PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_-_5706186	3.316	NM_033034 NM_033092 NM_033093	TRIM5	tripartite motif containing 5
chr8_+_97657581	3.313		PGCP	plasma glutamate carboxypeptidase
chrX_-_101112548	3.277	NM_032946	NXF5	nuclear RNA export factor 5
chr12_-_56709656	3.237		CNPY2	canopy 2 homolog (zebrafish)
chr8_+_96145968	3.191		PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr3_-_11623829	3.147	NM_001128220	VGLL4	vestigial like 4 (Drosophila)
chr8_-_79717540	3.120	NM_000880 NM_001199886 NM_001199887 NM_001199888	IL7	interleukin 7
chr1_+_19971865	3.098	NM_001204085	NBL1	neuroblastoma, suppression of tumorigenicity 1
chr4_-_100242487	3.078	NM_000668	ADH1A ADH1B	alcohol dehydrogenase 1A (class I), alpha polypeptide alcohol dehydrogenase 1B (class I), beta polypeptide
chr5_-_96143573	3.077		ERAP1	endoplasmic reticulum aminopeptidase 1
chr6_-_31704281	2.992		CLIC1	chloride intracellular channel 1
chr1_+_151372009	2.948	NM_002796	PSMB4	proteasome (prosome, macropain) subunit, beta type, 4
chr4_+_87856152	2.940	NM_001166693	AFF1	AF4/FMR2 family, member 1
chr2_-_231090443	2.938	NM_001185015	SP110	SP110 nuclear body protein
chr3_-_114343052	2.928	NM_001164347	ZBTB20	zinc finger and BTB domain containing 20
chr2_-_191878883	2.927		STAT1	signal transducer and activator of transcription 1, 91kDa
chr5_+_6746100	2.915	NM_001171806	PAPD7	PAP associated domain containing 7
chr11_+_65190267	2.904		NEAT1	nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr21_+_43933983	2.895		SLC37A1	solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_-_144520987	2.877		LOC728855	uncharacterized LOC728855
chr8_+_97505876	2.849	NM_002998	SDC2	syndecan 2
chr12_+_70636773	2.803	NM_014515 NM_001199302	CNOT2	CCR4-NOT transcription complex, subunit 2
chr19_+_13105970	2.802	NM_002501	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)
chr3_+_8543539	2.792		LMCD1	LIM and cysteine-rich domains 1
chr12_-_56709777	2.782		CNPY2	canopy 2 homolog (zebrafish)
chr4_+_76649826	2.768	NM_003715	USO1	USO1 vesicle docking protein homolog (yeast)
chr12_-_49319211	2.751	NM_001143782 NM_016594	FKBP11	FK506 binding protein 11, 19 kDa
chr12_-_31479084	2.708		FAM60A	family with sequence similarity 60, member A
chr5_-_96143689	2.693	NM_001040458 NM_016442	ERAP1	endoplasmic reticulum aminopeptidase 1
chr6_-_112575766	2.690	NM_001105206 NM_001105207 NM_001105208 NM_001105209 NM_002290	LAMA4	laminin, alpha 4
chr4_+_76649739	2.641		USO1	USO1 vesicle docking protein homolog (yeast)
chr16_+_50776012	2.615	NM_001042412	CYLD	cylindromatosis (turban tumor syndrome)
chr8_+_134203281	2.520	NM_001204869 NM_001204870 NM_003882 NM_080838	WISP1	WNT1 inducible signaling pathway protein 1
chr6_+_167525294	2.497	NM_004367	CCR6	chemokine (C-C motif) receptor 6
chr3_+_51977286	2.443		PARP3	poly (ADP-ribose) polymerase family, member 3
chr15_-_80263460	2.389	NM_001114735 NM_004049	BCL2A1	BCL2-related protein A1
chr7_-_42971730	2.347		PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2
chr12_-_9913415	2.345	NM_001781	CD69	CD69 molecule
chr3_+_69915374	2.345	NM_198177	MITF	microphthalmia-associated transcription factor
chr6_-_112575880	2.314		LAMA4	laminin, alpha 4
chr16_+_50775960	2.295	NM_001042355 NM_015247	CYLD	cylindromatosis (turban tumor syndrome)
chr22_+_39417117	2.292	NM_152426	APOBEC3D	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr5_+_96211643	2.236	NM_001130140 NM_022350	ERAP2	endoplasmic reticulum aminopeptidase 2
chr1_+_162602198	2.170	NM_001014796 NM_006182	DDR2	discoidin domain receptor tyrosine kinase 2
chr7_-_92463211	2.169	NM_001259	CDK6	cyclin-dependent kinase 6
chr1_+_104159953	2.150	NM_000699	AMY2A	amylase, alpha 2A (pancreatic)
chr8_+_97505895	2.105		SDC2	syndecan 2
chr8_+_97657592	2.090		PGCP	plasma glutamate carboxypeptidase
chr12_-_31479120	2.020	NM_001135811 NM_021238 NM_001135812	FAM60A	family with sequence similarity 60, member A
chr10_+_122610853	1.969		WDR11	WD repeat domain 11
chr6_+_25962978	1.956	NM_006355	TRIM38	tripartite motif containing 38
chr7_+_134464161	1.942	NM_004342 NM_033138 NM_033157	CALD1	caldesmon 1
chr19_-_11639929	1.898	NM_001142464 NM_001142465 NM_016581	ECSIT	ECSIT homolog (Drosophila)
chr12_-_31479038	1.883		FAM60A	family with sequence similarity 60, member A
chr1_+_2985730	1.875	NM_022114 NM_199454	PRDM16	PR domain containing 16
chr3_+_187871473	1.848	NM_001167672	LPP	LIM domain containing preferred translocation partner in lipoma
chr14_+_73525232	1.831		RBM25	RNA binding motif protein 25
chr9_-_34710062	1.756	NM_002989	CCL21	chemokine (C-C motif) ligand 21
chr2_+_231090443	1.729	NM_001005176 NM_007237	SP140	SP140 nuclear body protein
chr3_+_107241782	1.714	NM_001142568 NM_020235	BBX	bobby sox homolog (Drosophila)
chr21_-_43346780	1.645	NM_199050	C2CD2	C2 calcium-dependent domain containing 2
chr1_-_226070032	1.610		TMEM63A	transmembrane protein 63A
chr9_-_123676849	1.572	NM_001190947	TRAF1	TNF receptor-associated factor 1
chr11_-_104905849	1.550		CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr18_+_48405486	1.520		ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial
chr10_+_114135937	1.518	NM_016234	ACSL5	acyl-CoA synthetase long-chain family member 5
chr1_-_150738255	1.517		CTSS	cathepsin S
chr16_-_73092533	1.513	NM_001164766	ZFHX3	zinc finger homeobox 3
chr2_-_152146133	1.508		NMI	N-myc (and STAT) interactor
chr9_+_110045551	1.431		RAD23B	RAD23 homolog B (S. cerevisiae)
chr1_-_143744355	1.426		LOC100286793 FLJ39739	uncharacterized LOC100286793 uncharacterized FLJ39739
chr3_-_69129502	1.409	NM_003968 NM_198195	UBA3	ubiquitin-like modifier activating enzyme 3
chr17_+_30677187	1.409		ZNF207	zinc finger protein 207
chr19_+_34710327	1.402		LSM14A	LSM14A, SCD6 homolog A (S. cerevisiae)
chr9_+_110045516	1.347	NM_002874	RAD23B	RAD23 homolog B (S. cerevisiae)
chr14_+_73525267	1.314		RBM25	RNA binding motif protein 25
chr19_+_20188800	1.286	NM_007138	ZNF90	zinc finger protein 90
chr9_+_123850573	1.284	NM_007018	CNTRL	centriolin
chr20_+_56964162	1.248	NM_001195677 NM_004738	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C
chr22_-_31688329	1.241	NM_001135911 NM_052880	PIK3IP1	phosphoinositide-3-kinase interacting protein 1
chr20_+_389346	1.230		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_76649806	1.228		USO1	USO1 vesicle docking protein homolog (yeast)
chr6_-_24936177	1.226		FAM65B	family with sequence similarity 65, member B
chr22_-_36562224	1.217	NM_145641 NM_145642	APOL3	apolipoprotein L, 3
chr1_-_150780705	1.155	NM_000396	CTSK	cathepsin K
chr20_+_57470200	1.153		GNAS	GNAS complex locus
chr14_+_73525187	1.091	NM_021239	RBM25	RNA binding motif protein 25
chr12_+_102271349	1.081		DRAM1	DNA-damage regulated autophagy modulator 1
chr19_+_39109831	1.050		EIF3K	eukaryotic translation initiation factor 3, subunit K
chr19_-_23578226	1.037	NM_003430	ZNF91	zinc finger protein 91
chr14_-_24701472	1.031		NEDD8	neural precursor cell expressed, developmentally down-regulated 8
chr2_-_127864505	1.008	NM_004305 NM_139343 NM_139344 NM_139345 NM_139346 NM_139347 NM_139348 NM_139349 NM_139350 NM_139351	BIN1	bridging integrator 1
chrY_+_7142007	1.003		PRKY	protein kinase, Y-linked, pseudogene
chr2_+_231280870	0.996	NM_001080391 NM_001206701 NM_001206702 NM_001206703 NM_003113	SP100	SP100 nuclear antigen
chr11_-_4414887	0.987	NM_003141	TRIM21	tripartite motif containing 21
chr19_+_39109684	0.969	NM_013234	EIF3K	eukaryotic translation initiation factor 3, subunit K
chr1_-_150738232	0.967		CTSS	cathepsin S
chr10_+_114136014	0.951		ACSL5	acyl-CoA synthetase long-chain family member 5
chr11_+_5646206	0.898	NM_021616	TRIM34	tripartite motif containing 34
chr8_-_42065037	0.869		PLAT	plasminogen activator, tissue
chr22_-_30642683	0.852	NM_002309	LIF	leukemia inhibitory factor (cholinergic differentiation factor)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.95	1.39e-05	GO:0002376	immune system process
79.47	3.86e-05	GO:0002483	antigen processing and presentation of endogenous peptide antigen
79.47	3.86e-05	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
15.00	4.25e-05	GO:0006521	regulation of cellular amino acid metabolic process
11.47	6.81e-05	GO:0031575	mitotic cell cycle G1/S transition checkpoint
11.47	6.81e-05	GO:0071779	G1/S transition checkpoint
3.34	9.40e-05	GO:0006508	proteolysis
10.91	1.06e-04	GO:2000045	regulation of G1/S transition of mitotic cell cycle
13.03	1.32e-04	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
13.03	1.32e-04	GO:0072395	signal transduction involved in cell cycle checkpoint
13.03	1.32e-04	GO:0072401	signal transduction involved in DNA integrity checkpoint
13.03	1.32e-04	GO:0072404	signal transduction involved in G1/S transition checkpoint
13.03	1.32e-04	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
13.03	1.32e-04	GO:0072422	signal transduction involved in DNA damage checkpoint
13.03	1.32e-04	GO:0072431	signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
13.03	1.32e-04	GO:0072474	signal transduction involved in mitotic cell cycle G1/S checkpoint
12.82	1.50e-04	GO:0060337	type I interferon-mediated signaling pathway
12.82	1.50e-04	GO:0071357	cellular response to type I interferon
10.40	1.60e-04	GO:0030330	DNA damage response, signal transduction by p53 class mediator
12.62	1.70e-04	GO:0034340	response to type I interferon
2.14	1.87e-04	GO:0048522	positive regulation of cellular process
12.42	1.93e-04	GO:0033238	regulation of cellular amine metabolic process
12.42	1.93e-04	GO:0071158	positive regulation of cell cycle arrest
2.22	1.95e-04	GO:0090304	nucleic acid metabolic process
56.77	2.66e-04	GO:0019883	antigen processing and presentation of endogenous antigen
11.87	2.77e-04	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.69	3.11e-04	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint
11.36	3.91e-04	GO:0051352	negative regulation of ligase activity
11.36	3.91e-04	GO:0051444	negative regulation of ubiquitin-protein ligase activity
1.67	4.30e-04	GO:0043170	macromolecule metabolic process
11.20	4.37e-04	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.01	6.18e-04	GO:0048518	positive regulation of biological process
7.47	7.52e-04	GO:0010565	regulation of cellular ketone metabolic process
10.33	8.21e-04	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
10.19	9.07e-04	GO:0000216	M/G1 transition of mitotic cell cycle
10.19	9.07e-04	GO:0051443	positive regulation of ubiquitin-protein ligase activity
1.98	1.03e-03	GO:0051171	regulation of nitrogen compound metabolic process
8.36	1.04e-03	GO:0042770	signal transduction in response to DNA damage
3.21	1.09e-03	GO:0006955	immune response
9.94	1.10e-03	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
8.28	1.13e-03	GO:0000084	S phase of mitotic cell cycle
2.31	1.21e-03	GO:0016070	RNA metabolic process
8.13	1.32e-03	GO:0051320	S phase
9.70	1.33e-03	GO:0051351	positive regulation of ligase activity
3.71	1.49e-03	GO:0044265	cellular macromolecule catabolic process
2.95	1.56e-03	GO:0051704	multi-organism process
9.14	2.09e-03	GO:0031397	negative regulation of protein ubiquitination
1.44	2.38e-03	GO:0050789	regulation of biological process
4.51	2.39e-03	GO:0051603	proteolysis involved in cellular protein catabolic process
8.84	2.71e-03	GO:0051438	regulation of ubiquitin-protein ligase activity
4.42	2.99e-03	GO:0044257	cellular protein catabolic process
6.41	3.02e-03	GO:0031400	negative regulation of protein modification process
7.22	3.57e-03	GO:0007093	mitotic cell cycle checkpoint
8.46	3.76e-03	GO:0051340	regulation of ligase activity
30.57	5.18e-03	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
1.79	5.55e-03	GO:0060255	regulation of macromolecule metabolic process
4.16	6.05e-03	GO:0044419	interspecies interaction between organisms
4.13	6.47e-03	GO:0030163	protein catabolic process
1.40	7.76e-03	GO:0065007	biological regulation
7.57	8.57e-03	GO:0090068	positive regulation of cell cycle process
6.44	9.05e-03	GO:0000082	G1/S transition of mitotic cell cycle
4.30	9.11e-03	GO:0019941	modification-dependent protein catabolic process
1.63	9.13e-03	GO:0044260	cellular macromolecule metabolic process
7.50	9.19e-03	GO:0000077	DNA damage checkpoint
4.27	9.77e-03	GO:0043632	modification-dependent macromolecule catabolic process
7.36	1.05e-02	GO:0031398	positive regulation of protein ubiquitination
3.20	1.14e-02	GO:0009057	macromolecule catabolic process
1.73	1.22e-02	GO:0080090	regulation of primary metabolic process
1.86	1.32e-02	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.16	1.35e-02	GO:0051726	regulation of cell cycle
5.40	1.37e-02	GO:0019221	cytokine-mediated signaling pathway
7.04	1.47e-02	GO:0031570	DNA integrity checkpoint
49.67	1.54e-02	GO:0016553	base conversion or substitution editing
4.80	1.58e-02	GO:0032269	negative regulation of cellular protein metabolic process
3.00	1.62e-02	GO:0002682	regulation of immune system process
2.56	1.71e-02	GO:0042981	regulation of apoptosis
1.66	1.81e-02	GO:0019222	regulation of metabolic process
1.70	1.84e-02	GO:0031323	regulation of cellular metabolic process
1.42	1.96e-02	GO:0050794	regulation of cellular process
2.54	1.97e-02	GO:0043067	regulation of programmed cell death
1.41	2.03e-02	GO:0008152	metabolic process
5.81	2.06e-02	GO:0010498	proteasomal protein catabolic process
5.81	2.06e-02	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
2.67	2.11e-02	GO:0010605	negative regulation of macromolecule metabolic process
1.46	2.31e-02	GO:0050896	response to stimulus
4.60	2.36e-02	GO:0051248	negative regulation of protein metabolic process
4.22	2.39e-02	GO:0034097	response to cytokine stimulus
2.50	2.54e-02	GO:0010941	regulation of cell death
6.31	3.23e-02	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
4.88	3.32e-02	GO:0071345	cellular response to cytokine stimulus
19.87	3.32e-02	GO:0048002	antigen processing and presentation of peptide antigen
19.87	3.32e-02	GO:0070206	protein trimerization
1.88	3.45e-02	GO:0006950	response to stress
3.77	3.57e-02	GO:0045087	innate immune response
4.05	3.58e-02	GO:0006511	ubiquitin-dependent protein catabolic process
4.32	4.11e-02	GO:0007346	regulation of mitotic cell cycle
2.69	4.39e-02	GO:0006952	defense response
2.69	4.48e-02	GO:0044093	positive regulation of molecular function

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
14.20	1.85e-06	GO:0000502	proteasome complex
29.81	4.76e-06	GO:0005839	proteasome core complex
1.48	5.44e-03	GO:0005634	nucleus
99.34	1.45e-02	GO:0071797	LUBAC complex
66.23	4.33e-02	GO:0005588	collagen type V
66.23	4.33e-02	GO:0008537	proteasome activator complex
66.23	4.33e-02	GO:0030895	apolipoprotein B mRNA editing enzyme complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
28.39	7.66e-06	GO:0004298	threonine-type endopeptidase activity
28.39	7.66e-06	GO:0070003	threonine-type peptidase activity
1.23	7.57e-04	GO:0005488	binding
2.08	8.69e-04	GO:0008270	zinc ion binding
3.42	9.62e-04	GO:0070011	peptidase activity, acting on L-amino acid peptides
3.30	1.57e-03	GO:0008233	peptidase activity
1.39	4.96e-03	GO:0005515	protein binding
1.87	7.86e-03	GO:0046914	transition metal ion binding
3.64	1.08e-02	GO:0004175	endopeptidase activity
12.82	4.23e-02	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines