Motif ID: RBPJ.p2

Z-value: 1.562


Transcription factors associated with RBPJ.p2:

Gene SymbolEntrez IDGene Name
RBPJ 3516 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RBPJchr4_+_26321307-0.127.4e-02Click!


Activity profile for motif RBPJ.p2.

activity profile for motif RBPJ.p2


Sorted Z-values histogram for motif RBPJ.p2

Sorted Z-values for motif RBPJ.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RBPJ.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_47895168 27.852 ZNFX1-AS1
ZNFX1 antisense RNA 1 (non-protein coding)
chr19_+_37407230 23.557 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr19_-_50528683 15.922 NM_001025778
NM_016440
VRK3

vaccinia related kinase 3

chr10_-_61469322 14.989 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr7_+_150130741 11.230 LOC285972
uncharacterized LOC285972
chr1_-_160681552 11.147 NM_001778
CD48
CD48 molecule
chr19_-_50528576 11.069 VRK3
vaccinia related kinase 3
chr19_-_50528627 10.843 VRK3
vaccinia related kinase 3
chr19_-_5680910 10.834 NM_205767
C19orf70
chromosome 19 open reading frame 70
chr11_+_61129831 10.650 TMEM138
transmembrane protein 138
chr19_-_37019169 10.285 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr11_-_113746205 9.870 NM_020886
USP28
ubiquitin specific peptidase 28
chr3_-_51533996 8.655 NM_001171904
NM_014703
VPRBP

Vpr (HIV-1) binding protein

chrX_-_19140581 8.541 NM_001079858
NM_001079859
NM_001079860
NM_001184833
NM_001184834
NM_001184835
NM_001184836
NM_001184837
NM_005756
GPR64








G protein-coupled receptor 64








chr9_+_111624545 8.228 NM_006687
ACTL7A
actin-like 7A
chr19_+_37998041 8.035 ZNF793
zinc finger protein 793
chr1_-_186344383 7.191 TPR
translocated promoter region (to activated MET oncogene)
chr3_+_101546833 7.162 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_-_35324645 7.049 NM_001164824
C1orf212
chromosome 1 open reading frame 212
chr5_-_39074478 7.011 RICTOR
RPTOR independent companion of MTOR, complex 2
chr7_+_117864711 6.913 NM_019644
ANKRD7
ankyrin repeat domain 7
chr1_-_186344330 6.900 TPR
translocated promoter region (to activated MET oncogene)
chr19_+_5681016 6.785 NM_198704
NM_198705
NM_198533
NM_198707
NM_198706
NM_198708
HSD11B1L





hydroxysteroid (11-beta) dehydrogenase 1-like





chr6_+_42531767 6.692 UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr1_-_186344801 6.473 TPR
translocated promoter region (to activated MET oncogene)
chrX_-_73834460 6.415 NM_016120
NM_183353
RLIM

ring finger protein, LIM domain interacting

chr1_-_186344241 6.381 TPR
translocated promoter region (to activated MET oncogene)
chr6_+_42531951 6.234 UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr1_-_186344389 6.054 NM_003292
TPR
translocated promoter region (to activated MET oncogene)
chrX_-_103401607 5.848 NM_001012755
MCART6
mitochondrial carrier triple repeat 6
chr8_+_70405027 5.755 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr1_+_36689996 5.716 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr9_+_100174369 5.694 TDRD7
tudor domain containing 7
chr2_-_192015733 5.690 STAT4
signal transducer and activator of transcription 4
chr19_-_37157718 5.546 NM_153257
ZNF461
zinc finger protein 461
chr13_+_37006408 5.539 NM_001111045
NM_003914
CCNA1

cyclin A1

chr19_+_39899749 5.507


chrX_-_70331297 5.454 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr19_+_50529211 5.452 NM_001006656
NM_015428
ZNF473

zinc finger protein 473

chr15_+_89631731 5.411 ABHD2
abhydrolase domain containing 2
chr5_-_137514299 5.238 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr16_+_28565225 5.206 NM_138414
CCDC101
coiled-coil domain containing 101
chr13_+_37006628 5.189 CCNA1
cyclin A1
chr15_+_89631695 5.176 ABHD2
abhydrolase domain containing 2
chr2_-_24346143 5.137 NM_199346
PFN4
profilin family, member 4
chr15_+_89631625 5.087 ABHD2
abhydrolase domain containing 2
chr6_-_32163890 5.054 NOTCH4
notch 4
chr11_-_32452358 5.031 NM_001198551
NM_001198552
WT1

Wilms tumor 1

chr11_-_111250156 5.006 NM_006235
POU2AF1
POU class 2 associating factor 1
chr2_+_48844936 4.938 NM_001193487
NM_006872
GTF2A1L

general transcription factor IIA, 1-like

chr19_+_5681139 4.931 HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr16_+_28565279 4.880 CCDC101
coiled-coil domain containing 101
chr3_+_32726659 4.802 NM_015442
CNOT10
CCR4-NOT transcription complex, subunit 10
chr2_-_192015706 4.725 STAT4
signal transducer and activator of transcription 4
chr17_-_34257730 4.659 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr16_+_69984809 4.617 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr22_+_22697538 4.477


chr2_-_192015751 4.452 STAT4
signal transducer and activator of transcription 4
chr19_+_57831824 4.438 NM_213598
ZNF543
zinc finger protein 543
chr11_-_64510461 4.257 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr4_-_87813546 4.242 NM_144645
C4orf36
chromosome 4 open reading frame 36
chr16_-_30103204 4.203 NM_004608
TBX6
T-box 6
chr11_-_111249902 4.149 POU2AF1
POU class 2 associating factor 1
chr12_+_85430098 4.138 NM_001079910
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chr21_+_17102370 4.071 NM_013396
USP25
ubiquitin specific peptidase 25
chr1_+_36690038 4.050 THRAP3
thyroid hormone receptor associated protein 3
chr15_-_83654854 3.992 LOC100131860
uncharacterized LOC100131860
chr3_+_193853937 3.984 HES1
hairy and enhancer of split 1, (Drosophila)
chr7_+_47694841 3.983 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr19_+_50529294 3.950 ZNF473
zinc finger protein 473
chrX_-_134971142 3.921 NM_001017438
CT45A3
CT45A4
CT45A5
CT45A6
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A5
cancer/testis antigen family 45, member A6
cancer/testis antigen family 45, member A1
chr14_-_23285011 3.901 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr16_-_3306586 3.793 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr1_+_93811500 3.760 DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr19_+_50529276 3.746 ZNF473
zinc finger protein 473
chr2_+_233562042 3.743 GIGYF2
GRB10 interacting GYF protein 2
chr16_+_67226027 3.720 NM_001950
E2F4
E2F transcription factor 4, p107/p130-binding
chr1_+_93811463 3.718 DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr2_-_192015934 3.688 NM_003151
STAT4
signal transducer and activator of transcription 4
chr3_+_171561138 3.682 NM_001164436
TMEM212
transmembrane protein 212
chr2_-_160761192 3.665 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr7_-_128045995 3.597 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr16_+_57702156 3.489 NM_170776
GPR97
G protein-coupled receptor 97
chr6_+_126070813 3.453 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr6_+_49518358 3.447 C6orf141
chromosome 6 open reading frame 141
chr1_+_54519259 3.447 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr9_-_123688352 3.439 TRAF1
TNF receptor-associated factor 1
chr1_-_89664510 3.409 NM_052941
GBP4
guanylate binding protein 4
chr19_+_5904842 3.408 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr11_+_94706780 3.374 NM_018039
KDM4D
lysine (K)-specific demethylase 4D
chr6_+_126070724 3.362 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr17_-_56160564 3.310


chr6_-_27440459 3.302 NM_007149
ZNF184
zinc finger protein 184
chr19_-_36980758 3.289 ZNF566
zinc finger protein 566
chr19_-_6481765 3.273 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr19_+_37341259 3.272 NM_003419
ZNF345
zinc finger protein 345
chr19_-_55866063 3.235 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr16_+_23765947 3.234 NM_022097
CHP2
calcineurin B homologous protein 2
chr19_+_52772847 3.185 ZNF766
zinc finger protein 766
chr16_+_577833 3.132 NM_005632
SOLH
small optic lobes homolog (Drosophila)
chr19_-_53758107 3.130 NM_182609
ZNF677
zinc finger protein 677
chrX_-_15620191 3.128 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr5_+_178322915 3.127 NM_030613
ZFP2
zinc finger protein 2 homolog (mouse)
chr9_-_123676849 3.124 NM_001190947
TRAF1
TNF receptor-associated factor 1
chrX_+_153533408 3.122 NM_001145934
TKTL1
transketolase-like 1
chrX_+_24483343 3.114 NM_001142386
NM_005391
PDK3

pyruvate dehydrogenase kinase, isozyme 3

chr10_-_43048029 3.108 ZNF37BP
zinc finger protein 37B, pseudogene
chr12_+_56623819 3.103 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr4_-_84255999 3.101 HPSE
heparanase
chr9_-_123689172 3.091 NM_005658
TRAF1
TNF receptor-associated factor 1
chr11_+_67085309 3.091 LOC100130987
uncharacterized LOC100130987
chr1_+_151735444 3.088 NM_001134939
OAZ3
ornithine decarboxylase antizyme 3
chr2_-_170219012 3.082 NM_004525
LRP2
low density lipoprotein receptor-related protein 2
chr11_-_64647136 3.078 EHD1
EH-domain containing 1
chr19_+_38893828 3.073 FAM98C
family with sequence similarity 98, member C
chr3_+_99357439 3.054 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr13_-_25496913 3.019 CENPJ
centromere protein J
chr2_-_192016293 3.009 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr2_+_218990735 3.008 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr7_+_99933780 2.980 PILRB
paired immunoglobin-like type 2 receptor beta
chr11_+_2421983 2.979 TSSC4
tumor suppressing subtransferable candidate 4
chr11_-_64510339 2.971 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr12_+_9822205 2.968 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr1_+_45805877 2.967 TOE1
target of EGR1, member 1 (nuclear)
chr12_+_133707212 2.960 NM_015394
ZNF10
zinc finger protein 10
chr16_+_25078220 2.945 LOC283887
uncharacterized LOC283887
chr10_-_88281486 2.937 WAPAL
wings apart-like homolog (Drosophila)
chr14_-_53258145 2.935 GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr3_+_142442855 2.933


chr1_+_55464605 2.924 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr14_-_24658010 2.899 NM_024658
IPO4
importin 4
chr22_-_46933066 2.886 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr14_-_24657986 2.883 IPO4
importin 4
chr15_+_91260575 2.878 NM_000057
BLM
Bloom syndrome, RecQ helicase-like
chr20_-_44175995 2.859 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr19_-_51504799 2.840 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr8_+_70405080 2.817 SULF1
sulfatase 1
chr19_-_44809126 2.811 NM_004234
ZNF235
zinc finger protein 235
chr17_-_16118789 2.799 NM_006311
NCOR1
nuclear receptor corepressor 1
chr19_-_49176263 2.788 NM_145807
NTN5
netrin 5
chr2_-_160761266 2.785 NM_001198759
NM_001198760
NM_002349
LY75-CD302

LY75
LY75-CD302 readthrough

lymphocyte antigen 75
chr19_+_54024176 2.752 NM_018555
ZNF331
zinc finger protein 331
chr19_+_16222706 2.727 RAB8A
RAB8A, member RAS oncogene family
chr19_-_2042022 2.696 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr2_-_170218972 2.695 LRP2
low density lipoprotein receptor-related protein 2
chr18_-_28622624 2.669 NM_001941
NM_024423
DSC3

desmocollin 3

chr6_+_31082526 2.651 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr13_-_25497054 2.643 NM_018451
CENPJ
centromere protein J
chr8_+_96145968 2.643 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr1_+_111413820 2.640 NM_001040033
CD53
CD53 molecule
chr11_+_289113 2.631 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr11_+_76745434 2.625 NM_138706
B3GNT6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr19_+_52772823 2.625 NM_001010851
ZNF766
zinc finger protein 766
chr13_+_39612440 2.624 NM_001012754
NM_001017370
NHLRC3

NHL repeat containing 3

chr2_+_233562031 2.617 GIGYF2
GRB10 interacting GYF protein 2
chr3_-_170626381 2.598 EIF5A2
eukaryotic translation initiation factor 5A2
chr5_-_169724817 2.597 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_-_36505102 2.567 ALKBH6
alkB, alkylation repair homolog 6 (E. coli)
chr14_+_97263681 2.566 NM_003384
VRK1
vaccinia related kinase 1
chr2_-_25474948 2.536 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr16_+_67226070 2.516 E2F4
E2F transcription factor 4, p107/p130-binding
chr3_-_136471186 2.513 NM_005862
STAG1
stromal antigen 1
chrX_-_16888175 2.508 RBBP7
retinoblastoma binding protein 7
chr14_-_61115906 2.497 NM_005982
SIX1
SIX homeobox 1
chr9_+_100174179 2.487 NM_014290
TDRD7
tudor domain containing 7
chr17_+_38474472 2.459 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr8_+_96146097 2.454 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr11_+_67195886 2.437 NM_003952
RPS6KB2
ribosomal protein S6 kinase, 70kDa, polypeptide 2
chr19_-_49401937 2.418 NM_003323
TULP2
tubby like protein 2
chr10_-_99205742 2.412 NM_016046
EXOSC1
exosome component 1
chr19_-_12512022 2.399 NM_001080821
ZNF799
zinc finger protein 799
chr19_-_58514136 2.374 ZNF606
zinc finger protein 606
chr4_-_80329354 2.360 NM_033214
GK2
glycerol kinase 2
chr11_+_66512241 2.352 C11orf80
chromosome 11 open reading frame 80
chr19_-_12551762 2.345 ZNF443
zinc finger protein 443
chr19_+_13842564 2.342 CCDC130
coiled-coil domain containing 130
chr17_+_38474544 2.319 RARA
retinoic acid receptor, alpha
chr12_+_133614138 2.300 ZNF84
zinc finger protein 84
chr3_-_167191808 2.299 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr19_+_33182689 2.287 NM_001105570
NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr10_-_88281515 2.274 NM_015045
WAPAL
wings apart-like homolog (Drosophila)
chr11_+_66512164 2.248 NM_024650
C11orf80
chromosome 11 open reading frame 80
chr2_-_63815581 2.247 WDPCP
WD repeat containing planar cell polarity effector
chr16_+_84178864 2.243 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr16_+_8715473 2.240 NM_024109
METTL22
methyltransferase like 22
chr2_+_109271484 2.223 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr17_+_38474513 2.219 RARA
retinoic acid receptor, alpha
chr20_+_42143045 2.211 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr12_+_133614052 2.210 ZNF84
zinc finger protein 84
chr16_+_30662057 2.208 PRR14
proline rich 14
chr4_-_83719896 2.202 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chrX_-_70288155 2.187 NM_013346
SNX12
sorting nexin 12
chr22_+_40322609 2.182 GRAP2
GRB2-related adaptor protein 2
chr5_+_68788387 2.162 NM_001205254
OCLN
occludin
chr11_+_28129797 2.156 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr17_+_26698986 2.155 NM_015077
SARM1
sterile alpha and TIR motif containing 1
chr9_-_140317583 2.155 EXD3
exonuclease 3'-5' domain containing 3
chr10_-_90342947 2.149 NM_001031709
NM_018363
RNLS

renalase, FAD-dependent amine oxidase

chr12_+_12224401 2.144 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr4_-_120548329 2.134 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 1.31e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.20 3.76e-07 GO:0065007 biological regulation
1.50 7.22e-07 GO:0006355 regulation of transcription, DNA-dependent
1.46 1.66e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.20 3.78e-06 GO:0050789 regulation of biological process
1.36 4.42e-06 GO:0060255 regulation of macromolecule metabolic process
1.45 7.63e-06 GO:0051252 regulation of RNA metabolic process
1.40 9.85e-06 GO:0009889 regulation of biosynthetic process
1.40 1.37e-05 GO:0031326 regulation of cellular biosynthetic process
1.20 3.60e-05 GO:0050794 regulation of cellular process
1.40 4.00e-05 GO:0010468 regulation of gene expression
1.38 8.17e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 9.81e-05 GO:0019222 regulation of metabolic process
1.31 1.71e-04 GO:0031323 regulation of cellular metabolic process
1.31 2.01e-04 GO:0080090 regulation of primary metabolic process
1.36 2.02e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.40 1.39e-02 GO:0009059 macromolecule biosynthetic process
1.70 1.62e-02 GO:0051726 regulation of cell cycle
1.40 1.70e-02 GO:0034645 cellular macromolecule biosynthetic process
2.04 2.58e-02 GO:0002520 immune system development
4.40 4.91e-02 GO:0000080 G1 phase of mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 1.02e-09 GO:0005634 nucleus
1.09 1.49e-04 GO:0005622 intracellular
1.10 1.87e-04 GO:0044424 intracellular part
1.37 3.25e-04 GO:0044428 nuclear part
1.11 1.14e-03 GO:0043226 organelle
1.12 1.41e-03 GO:0043227 membrane-bounded organelle
1.12 1.55e-03 GO:0043231 intracellular membrane-bounded organelle
1.11 1.92e-03 GO:0043229 intracellular organelle
1.36 4.40e-03 GO:0031981 nuclear lumen
1.31 7.62e-03 GO:0043233 organelle lumen
1.29 1.48e-02 GO:0031974 membrane-enclosed lumen
1.41 1.59e-02 GO:0005654 nucleoplasm
1.30 1.87e-02 GO:0070013 intracellular organelle lumen
3.17 3.43e-02 GO:0000123 histone acetyltransferase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 8.74e-11 GO:0005488 binding
1.49 2.59e-08 GO:0003677 DNA binding
1.38 7.26e-08 GO:0003676 nucleic acid binding
1.40 1.79e-05 GO:0046914 transition metal ion binding
1.43 3.47e-05 GO:0008270 zinc ion binding
1.55 1.73e-03 GO:0001071 nucleic acid binding transcription factor activity
1.55 1.73e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.21 1.45e-02 GO:0046872 metal ion binding
1.21 1.55e-02 GO:0043169 cation binding
1.21 1.90e-02 GO:0043167 ion binding