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• Activity deltas table
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Motif ID: REST.p3

Z-value: 4.061

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr20_+_44657812	160.702	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_158141735	154.459	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr20_+_44657858	151.763		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr20_+_5891973	140.293	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr12_+_175872	135.359	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chrX_-_47479229	134.497	NM_006950 NM_133499	SYN1	synapsin I
chr14_+_93389444	127.147	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr3_-_187388105	125.702	NM_001048	SST	somatostatin
chr1_+_33352071	121.804	NM_002143	HPCA	hippocalcin
chr14_+_93389491	118.937		CHGA	chromogranin A (parathyroid secretory protein 1)
chr17_+_42385780	110.196	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr12_+_113229548	105.900	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr11_-_123524881	100.407		SCN3B	sodium channel, voltage-gated, type III, beta
chr1_-_241520467	96.953	NM_002924	RGS7	regulator of G-protein signaling 7
chr16_+_24267474	90.552		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr8_-_57358511	88.354	NM_006211	PENK	proenkephalin
chr17_+_30813928	86.272	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chrX_-_49056638	84.939	NM_003179	SYP	synaptophysin
chr11_-_66115016	83.534	NM_006876	B3GNT1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr14_-_51561657	80.899		TRIM9	tripartite motif containing 9
chr15_-_83378488	75.115	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr16_+_24267672	74.936		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr11_+_45907046	71.884	NM_005456	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr11_+_45907198	70.301		MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr10_-_50970321	67.745	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chr10_-_102790850	66.807		PDZD7	PDZ domain containing 7
chr15_+_75287829	63.321	NM_001178111 NM_001178112 NM_138967	SCAMP5	secretory carrier membrane protein 5
chr11_-_75141015	61.216		KLHL35	kelch-like 35 (Drosophila)
chr10_+_26505593	57.618		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr10_-_102790877	57.369	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr19_-_55691468	56.445	NM_003180	SYT5	synaptotagmin V
chr8_-_91094924	54.120	NM_004929	CALB1	calbindin 1, 28kDa
chr16_+_5008317	50.248	NM_014692	SEC14L5	SEC14-like 5 (S. cerevisiae)
chr10_+_26505235	50.115	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr3_-_48700317	46.005	NM_001407	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr17_-_3337134	41.298	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chr3_+_62305395	41.255	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr1_-_241520384	39.959		RGS7	regulator of G-protein signaling 7
chr6_+_154360442	39.803	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145284 NM_001145285 NM_001145286	OPRM1	opioid receptor, mu 1
chr3_+_62304667	38.894		C3orf14	chromosome 3 open reading frame 14
chrX_-_153141398	37.699	NM_000425 NM_001143963 NM_024003	L1CAM	L1 cell adhesion molecule
chr9_-_139096954	35.214	NM_178138	LHX3	LIM homeobox 3
chr6_+_25652373	33.501	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr2_+_46524448	30.937	NM_001430	EPAS1	endothelial PAS domain protein 1
chr9_+_140033588	30.738	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr4_-_175750377	30.011	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr6_+_44238479	28.192	NM_001137560	TMEM151B	transmembrane protein 151B
chr20_-_60795270	26.939	NM_007232	HRH3	histamine receptor H3
chr2_-_51259536	26.747	NM_001135659 NM_004801	NRXN1	neurexin 1
chr17_-_3301703	24.791	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr1_-_175712669	24.361	NM_003285	TNR	tenascin R (restrictin, janusin)
chr19_-_3971032	24.163		DAPK3	death-associated protein kinase 3
chr11_+_62380212	23.032	NM_000327	ROM1	retinal outer segment membrane protein 1
chr15_+_69222838	22.378	NM_145658 NM_001184780	SPESP1 NOX5	sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5
chr11_-_125773086	21.790	NM_031307	PUS3	pseudouridylate synthase 3
chr1_+_154540250	21.390	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr19_-_3971089	20.111		DAPK3	death-associated protein kinase 3
chr6_+_110300197	17.905	NM_005284	GPR6	G protein-coupled receptor 6
chr11_+_22359666	17.618	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr16_+_3019341	17.282	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chr2_-_220083658	16.404		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr5_-_151304322	16.054	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr10_+_102790984	15.856	NM_030971	SFXN3	sideroflexin 3
chr2_-_27531113	15.072	NM_003353	UCN	urocortin
chr7_-_100808832	14.789	NM_003378	VGF	VGF nerve growth factor inducible
chr5_+_175298604	14.770		CPLX2	complexin 2
chr19_+_34175433	14.215	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr14_-_94759594	14.165	NM_001100607	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_220083394	14.150		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chrX_+_153237990	14.002	NM_003492	TMEM187	transmembrane protein 187
chr20_+_13765645	13.675	NM_001039375 NM_024120	C20orf7	chromosome 20 open reading frame 7
chr15_-_27018917	13.356	NM_021912	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_-_151689246	12.715	NM_007185	CELF3	CUGBP, Elav-like family member 3
chr3_+_120627026	9.751	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr5_+_141303366	8.520	NM_001142603 NM_014773	KIAA0141	KIAA0141
chr9_+_138453599	8.422	NM_001018049 NM_002571	PAEP	progestagen-associated endometrial protein
chr5_+_71014989	8.181	NM_004291	CARTPT	CART prepropeptide
chr11_+_637268	7.451	NM_000797	DRD4	dopamine receptor D4
chr7_+_145813452	6.851	NM_014141	CNTNAP2	contactin associated protein-like 2
chr8_+_68864341	6.843		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_-_153141284	6.802		L1CAM	L1 cell adhesion molecule
chr5_+_33936490	6.395	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr5_+_141303463	5.994		KIAA0141	KIAA0141
chr9_-_123812535	5.510	NM_001735	C5	complement component 5
chr1_-_20834609	4.821	NM_024544	MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr21_-_35828038	4.746	NM_001127670	KCNE1	potassium voltage-gated channel, Isk-related family, member 1
chr1_+_212606194	3.973	NM_013349	NENF	neudesin neurotrophic factor
chr12_+_71833518	3.872		LGR5	leucine-rich repeat containing G protein-coupled receptor 5
chr6_+_153071931	3.749	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr9_-_74061819	3.727		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr10_-_44880452	3.467	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr5_+_69696805	3.256		SMA4	glucuronidase, beta pseudogene
chr1_-_20834516	2.983		MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr22_+_20008633	2.760		C22orf25	chromosome 22 open reading frame 25
chr5_+_175298538	2.736		CPLX2	complexin 2
chr16_+_2510080	2.550	NM_025108	C16orf59	chromosome 16 open reading frame 59
chr6_+_43149905	2.186	NM_015089	CUL9	cullin 9
chr11_-_128807712	1.945	NM_001195194	TP53AIP1	tumor protein p53 regulated apoptosis inducing protein 1
chr5_-_69881965	1.370		SMA4	glucuronidase, beta pseudogene
chr7_+_134832765	1.222	NM_018295	TMEM140	transmembrane protein 140
chr20_+_57428035	1.059	NM_001077490 NM_080425	GNAS	GNAS complex locus
chr3_+_193853937	0.982		HES1	hairy and enhancer of split 1, (Drosophila)
chr1_+_171750829	0.839		METTL13	methyltransferase like 13
chr9_-_131038196	0.822	NM_004486	GOLGA2	golgin A2
chr11_-_6676851	0.816	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr1_-_13184325	0.681	NM_001136561	LOC440563	heterogeneous nuclear ribonucleoprotein C-like
chr5_-_135701163	0.542	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7
chr1_+_171750807	0.470		METTL13	methyltransferase like 13
chr11_+_32112607	0.414		RCN1	reticulocalbin 1, EF-hand calcium binding domain
chr1_+_25071906	0.042		CLIC4	chloride intracellular channel 4

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
8.99	1.97e-11	GO:0019226	transmission of nerve impulse
8.99	1.97e-11	GO:0035637	multicellular organismal signaling
9.59	2.97e-11	GO:0007268	synaptic transmission
4.72	2.22e-10	GO:0050877	neurological system process
4.04	1.61e-09	GO:0003008	system process
5.87	4.78e-08	GO:0007267	cell-cell signaling
6.86	1.44e-07	GO:0007186	G-protein coupled receptor protein signaling pathway
4.65	1.06e-06	GO:0007154	cell communication
2.41	3.78e-06	GO:0023052	signaling
13.22	1.24e-05	GO:0031644	regulation of neurological system process
6.50	4.27e-05	GO:0046903	secretion
6.40	5.07e-05	GO:0055082	cellular chemical homeostasis
7.69	8.61e-05	GO:0007610	behavior
12.98	8.90e-05	GO:0051969	regulation of transmission of nerve impulse
1.96	9.08e-05	GO:0032501	multicellular organismal process
6.12	2.67e-04	GO:0006873	cellular ion homeostasis
5.05	2.85e-04	GO:0048878	chemical homeostasis
5.30	4.36e-04	GO:0019725	cellular homeostasis
5.65	6.21e-04	GO:0050801	ion homeostasis
4.02	8.44e-04	GO:0006811	ion transport
2.35	8.51e-04	GO:0006810	transport
2.32	1.18e-03	GO:0051234	establishment of localization
2.18	1.21e-03	GO:0051179	localization
6.52	1.46e-03	GO:0044057	regulation of system process
2.61	2.06e-03	GO:0065008	regulation of biological quality
33.52	2.77e-03	GO:0060078	regulation of postsynaptic membrane potential
6.23	6.79e-03	GO:0032940	secretion by cell
11.39	7.09e-03	GO:0003001	generation of a signal involved in cell-cell signaling
11.39	7.09e-03	GO:0023061	signal release
10.78	9.71e-03	GO:0050804	regulation of synaptic transmission
46.40	1.63e-02	GO:0051954	positive regulation of amine transport
3.55	1.64e-02	GO:0042592	homeostatic process
21.75	1.64e-02	GO:0051952	regulation of amine transport
9.51	1.98e-02	GO:0042391	regulation of membrane potential
20.12	2.24e-02	GO:0051899	membrane depolarization
4.24	2.61e-02	GO:0006812	cation transport
11.84	3.19e-02	GO:0007218	neuropeptide signaling pathway
11.43	3.76e-02	GO:0001505	regulation of neurotransmitter levels
1.99	3.79e-02	GO:0007165	signal transduction
1.50	3.81e-02	GO:0065007	biological regulation
10.82	4.90e-02	GO:0007626	locomotory behavior

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
8.30	7.49e-09	GO:0045202	synapse
9.78	1.56e-08	GO:0044456	synapse part
10.14	4.88e-08	GO:0030659	cytoplasmic vesicle membrane
20.81	5.14e-08	GO:0008021	synaptic vesicle
9.80	7.43e-08	GO:0012506	vesicle membrane
5.60	8.22e-08	GO:0016023	cytoplasmic membrane-bounded vesicle
5.49	1.12e-07	GO:0031988	membrane-bounded vesicle
5.27	2.26e-07	GO:0031410	cytoplasmic vesicle
31.28	2.63e-07	GO:0030672	synaptic vesicle membrane
5.10	3.86e-07	GO:0031982	vesicle
8.42	4.74e-07	GO:0044433	cytoplasmic vesicle part
12.50	8.03e-07	GO:0030136	clathrin-coated vesicle
18.93	1.08e-06	GO:0030665	clathrin coated vesicle membrane
5.68	1.80e-06	GO:0030054	cell junction
10.22	5.52e-06	GO:0030135	coated vesicle
2.87	7.36e-06	GO:0044459	plasma membrane part
14.00	1.18e-05	GO:0030662	coated vesicle membrane
6.31	4.58e-05	GO:0043005	neuron projection
9.47	2.35e-04	GO:0043025	neuronal cell body
9.20	2.91e-04	GO:0044297	cell body
1.69	7.63e-04	GO:0044425	membrane part
7.74	1.04e-03	GO:0034702	ion channel complex
1.57	1.10e-03	GO:0016020	membrane
1.94	1.27e-03	GO:0005886	plasma membrane
1.92	1.80e-03	GO:0071944	cell periphery
7.50	4.83e-03	GO:0030425	dendrite
3.45	5.32e-03	GO:0042995	cell projection
35.49	9.07e-03	GO:0032589	neuron projection membrane
8.16	1.11e-02	GO:0045211	postsynaptic membrane
10.17	1.57e-02	GO:0019717	synaptosome
100.53	1.73e-02	GO:0032590	dendrite membrane
14.90	1.75e-02	GO:0034707	chloride channel complex
2.79	1.83e-02	GO:0005887	integral to plasma membrane
1.65	1.99e-02	GO:0031224	intrinsic to membrane
2.74	2.27e-02	GO:0031226	intrinsic to plasma membrane
1.64	2.93e-02	GO:0016021	integral to membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
4.08	5.07e-07	GO:0005215	transporter activity
6.34	4.90e-05	GO:0005216	ion channel activity
6.25	5.79e-05	GO:0022838	substrate-specific channel activity
6.06	8.01e-05	GO:0015267	channel activity
6.04	8.23e-05	GO:0022803	passive transmembrane transporter activity
16.76	2.00e-04	GO:0005230	extracellular ligand-gated ion channel activity
4.28	2.29e-04	GO:0015075	ion transmembrane transporter activity
6.69	3.11e-04	GO:0022836	gated channel activity
3.92	3.18e-04	GO:0022891	substrate-specific transmembrane transporter activity
38.30	4.26e-04	GO:0005184	neuropeptide hormone activity
21.40	4.66e-04	GO:0005231	excitatory extracellular ligand-gated ion channel activity
3.58	5.03e-04	GO:0022892	substrate-specific transporter activity
3.63	8.42e-04	GO:0022857	transmembrane transporter activity
12.20	1.29e-03	GO:0005179	hormone activity
46.40	4.39e-03	GO:0016594	glycine binding
9.66	4.88e-03	GO:0015276	ligand-gated ion channel activity
9.66	4.88e-03	GO:0022834	ligand-gated channel activity
100.53	1.96e-02	GO:0016933	extracellular-glycine-gated ion channel activity
100.53	1.96e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
80.43	3.26e-02	GO:0022824	transmitter-gated ion channel activity
80.43	3.26e-02	GO:0022835	transmitter-gated channel activity
3.53	3.53e-02	GO:0005509	calcium ion binding
3.76	4.17e-02	GO:0008324	cation transmembrane transporter activity
5.34	4.51e-02	GO:0005261	cation channel activity
67.02	4.87e-02	GO:0005237	inhibitory extracellular ligand-gated ion channel activity
8.18	4.89e-02	GO:0043176	amine binding