Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 4.795


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RFXANKchr19_+_19303732-0.651.0e-27Click!
RFX5chr1_-_151319717-0.551.1e-18Click!
RFX2chr19_-_61104910.533.3e-17Click!
RFX1chr19_-_141170960.339.2e-07Click!
RFX3chr9_-_35259730.321.2e-06Click!
RFXAPchr13_+_373933060.211.8e-03Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_48693934 120.976 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_-_62473502 102.367 NM_001130702
NM_032667
BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr5_-_149669400 96.744 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr15_+_71184781 84.004 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr14_-_60337350 82.734 NM_021136
RTN1
reticulon 1
chr3_-_58563070 77.569 FAM107A
family with sequence similarity 107, member A
chr16_+_8806825 74.745 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr11_+_133938819 74.342 NM_001205329
NM_032801
JAM3

junctional adhesion molecule 3

chr2_-_175869910 72.137 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr15_-_71184611 68.310 NM_020147
THAP10
THAP domain containing 10
chr11_+_133938965 64.937 JAM3
junctional adhesion molecule 3
chr19_-_55690717 64.808 SYT5
synaptotagmin V
chr14_-_74180341 63.828 NM_006029
PNMA1
paraneoplastic antigen MA1
chr17_-_5404304 58.504 NM_001162371
LOC728392
uncharacterized LOC728392
chr19_-_46974663 57.496 PNMAL1
PNMA-like 1
chr5_-_149669187 56.778 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr17_-_74137370 56.355 NM_001454
FOXJ1
forkhead box J1
chr20_+_43991739 55.130 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 readthrough
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr6_+_88117689 54.858 NM_001031743
C6orf165
chromosome 6 open reading frame 165
chr1_-_204380903 54.855 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr6_+_111303240 54.118 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr19_-_58609606 52.773 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr19_-_46974789 51.603 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr6_-_116575170 46.980 NM_021648
TSPYL4
TSPY-like 4
chr13_-_30881556 46.735 NM_032116
KATNAL1
katanin p60 subunit A-like 1
chr1_-_154155698 45.724 NM_001043351
NM_001043352
NM_001043353
NM_153649
TPM3



tropomyosin 3



chr19_+_1450117 45.043 NM_005883
APC2
adenomatosis polyposis coli 2
chr2_+_27193448 43.731 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr1_-_48937791 43.067 NM_019073
SPATA6
spermatogenesis associated 6
chr1_-_48937676 42.985 SPATA6
spermatogenesis associated 6
chr19_-_57352055 42.978 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr3_+_49027770 42.358 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr1_-_169396654 41.473 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr10_-_135150368 40.443 CALY
calcyon neuron-specific vesicular protein
chr22_+_38453478 40.177 PICK1
protein interacting with PRKCA 1
chr19_+_35634153 39.847 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chr16_+_67840976 39.826 NM_018430
TSNAXIP1
translin-associated factor X interacting protein 1
chr10_-_135150474 38.732 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr3_+_49027281 38.701 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr7_+_102715293 36.674 NM_001161009
NM_001161010
NM_001161011
NM_001161012
NM_001161013
NM_031905
ARMC10





armadillo repeat containing 10





chr5_+_79783799 36.524 NM_205548
FAM151B
family with sequence similarity 151, member B
chr9_+_135754284 35.183 NM_018956
C9orf9
chromosome 9 open reading frame 9
chr1_+_1550794 35.078 NM_001170686
NM_001170687
NM_001170688
NM_080875
MIB2



mindbomb homolog 2 (Drosophila)



chr16_+_84178864 34.980 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr7_-_102715171 34.828 NM_001111038
FBXL13
F-box and leucine-rich repeat protein 13
chr15_+_90792761 34.634 NM_001029964
TTLL13
tubulin tyrosine ligase-like family, member 13
chr8_-_98290072 34.506 TSPYL5
TSPY-like 5
chr4_-_87281177 34.453 MAPK10
mitogen-activated protein kinase 10
chr19_+_2096930 34.408 IZUMO4
IZUMO family member 4
chr6_-_35109003 33.850 NM_001093728
NM_018679
TCP11

t-complex 11 homolog (mouse)

chr17_-_64187814 33.808 NM_145036
NM_001199165
CEP112

centrosomal protein 112kDa

chr19_+_5681016 33.769 NM_198704
NM_198705
NM_198533
NM_198707
NM_198706
NM_198708
HSD11B1L





hydroxysteroid (11-beta) dehydrogenase 1-like





chr7_-_44228880 33.260 NM_000162
GCK
glucokinase (hexokinase 4)
chr22_-_31063786 33.111 NM_152511
DUSP18
dual specificity phosphatase 18
chr11_+_46958228 32.954 NM_001003676
NM_001003677
NM_001003678
NM_024113
C11orf49



chromosome 11 open reading frame 49



chr16_+_58283819 32.824 NM_001142302
NM_014157
CCDC113

coiled-coil domain containing 113

chr3_-_149688886 32.559 PFN2
profilin 2
chr17_-_8079607 32.383 NM_032354
NM_183065
TMEM107

transmembrane protein 107

chr7_-_129845216 32.024 NM_032842
TMEM209
transmembrane protein 209
chr7_+_102715580 32.018 ARMC10
armadillo repeat containing 10
chr7_-_140624280 32.000 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr13_+_37006408 31.386 NM_001111045
NM_003914
CCNA1

cyclin A1

chr11_-_115375065 31.371 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr16_+_8814567 31.288 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr21_+_18885104 31.176 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr17_-_80656461 31.169 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr1_-_154155594 30.921 TPM3
tropomyosin 3
chr3_-_49055916 30.918 NM_001009996
DALRD3
DALR anticodon binding domain containing 3
chr16_+_89724175 30.682 NM_153025
C16orf55
chromosome 16 open reading frame 55
chr21_+_18885296 30.582 CXADR
coxsackie virus and adenovirus receptor
chr1_-_163113938 30.317 RGS5
regulator of G-protein signaling 5
chr1_-_40157067 30.200 NM_016257
HPCAL4
hippocalcin like 4
chr11_+_67085309 30.091 LOC100130987
uncharacterized LOC100130987
chr19_+_50529294 29.752 ZNF473
zinc finger protein 473
chr5_-_74062885 29.751 NM_032380
NM_170681
NM_170691
GFM2


G elongation factor, mitochondrial 2


chr8_+_21916685 29.714 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr14_+_102829351 29.392 TECPR2
tectonin beta-propeller repeat containing 2
chr8_-_98290171 29.153 NM_033512
TSPYL5
TSPY-like 5
chr8_+_21916858 29.074 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr20_-_48531986 28.561 SPATA2
spermatogenesis associated 2
chr19_+_5681139 28.554 HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr22_+_41601285 28.086 NM_031488
L3MBTL2
l(3)mbt-like 2 (Drosophila)
chr19_-_4457789 27.985 NM_025241
UBXN6
UBX domain protein 6
chr6_-_70506472 27.891 LMBRD1
LMBR1 domain containing 1
chr6_+_111580481 27.730 NM_153369
KIAA1919
KIAA1919
chr1_-_21978287 27.288 NM_001145658
RAP1GAP
RAP1 GTPase activating protein
chr2_-_44588943 27.059 NM_001171603
NM_001171617
PREPL

prolyl endopeptidase-like

chr7_+_156433352 26.913 NM_030936
NM_001184996
RNF32

ring finger protein 32

chr19_+_50270263 26.889 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr2_+_79740059 26.841 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr13_+_42846255 26.613 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chr3_-_139108486 26.194


chr5_-_114505549 26.109 TRIM36
tripartite motif containing 36
chr1_+_180601121 25.992 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr20_-_48532036 25.833 SPATA2
spermatogenesis associated 2
chr19_+_35630391 25.755 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr4_+_113970784 25.580 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr10_-_127584967 25.176 DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr5_-_142065991 25.090 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr5_-_142065586 25.087 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr6_-_84937313 25.071 NM_014895
KIAA1009
KIAA1009
chr8_+_21912327 25.060 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr12_+_6930689 25.035 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chrX_-_14047958 24.910 NM_001042479
NM_001042480
NM_017856
GEMIN8


gem (nuclear organelle) associated protein 8


chr8_+_42010463 24.635 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr19_+_13842564 24.616 CCDC130
coiled-coil domain containing 130
chr11_-_64885124 24.472 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr17_-_1531543 24.422 SLC43A2
solute carrier family 43, member 2
chr2_-_110962577 24.277 NM_000272
NM_001128178
NM_001128179
NM_207181
NPHP1



nephronophthisis 1 (juvenile)



chr19_-_46295785 24.256 NM_004943
DMWD
dystrophia myotonica, WD repeat containing
chr16_+_1386197 24.177 NM_001199096
BAIAP3
BAI1-associated protein 3
chr11_+_28129797 24.152 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr2_-_44588622 23.908 NM_001171606
NM_001171613
PREPL

prolyl endopeptidase-like

chr22_+_38453261 23.794 NM_001039583
NM_001039584
NM_012407
PICK1


protein interacting with PRKCA 1


chr1_+_15573767 23.514 NM_052929
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr20_-_3869713 23.229


chr20_-_48532067 23.192 NM_006038
SPATA2
spermatogenesis associated 2
chr7_-_37025696 23.139 ELMO1
engulfment and cell motility 1
chr1_-_67390413 23.111 NM_024763
NM_207014
WDR78

WD repeat domain 78

chr19_+_2096792 23.060 NM_001031735
NM_001039846
IZUMO4

IZUMO family member 4

chr14_+_74486049 23.000 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr10_-_104179468 22.999 PSD
pleckstrin and Sec7 domain containing
chr8_+_22462286 22.890 KIAA1967
KIAA1967
chr19_+_50529211 22.667 NM_001006656
NM_015428
ZNF473

zinc finger protein 473

chr1_+_38022514 22.643 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr6_-_32163890 22.537 NOTCH4
notch 4
chr3_+_130745693 22.442 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr10_+_22634373 22.424 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr22_-_43485333 22.347 NM_012263
TTLL1
tubulin tyrosine ligase-like family, member 1
chr11_-_118123001 22.345 NM_198275
MPZL3
myelin protein zero-like 3
chr5_-_133702764 22.192 NM_001113575
NM_016508
CDKL3

cyclin-dependent kinase-like 3

chr2_+_79740171 21.830 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr8_+_22462273 21.809 KIAA1967
KIAA1967
chr10_+_12171580 21.781 NM_001142627
NM_001142628
NM_018144
SEC61A2


Sec61 alpha 2 subunit (S. cerevisiae)


chr1_-_85725315 21.682 NM_198077
C1orf52
chromosome 1 open reading frame 52
chr2_+_214149102 21.660 NM_001025436
NM_024532
SPAG16

sperm associated antigen 16

chrX_+_135251795 21.596 NM_001167819
FHL1
four and a half LIM domains 1
chr11_-_66360485 21.547 NM_018219
CCDC87
coiled-coil domain containing 87
chr13_-_96294282 21.415 DZIP1
DAZ interacting protein 1
chr11_+_66278076 21.383 NM_024649
BBS1
Bardet-Biedl syndrome 1
chr21_+_40817793 21.366 NM_001001713
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr19_+_50529276 21.326 ZNF473
zinc finger protein 473
chr2_-_2334887 21.302 NM_015025
MYT1L
myelin transcription factor 1-like
chr16_-_72206023 21.244 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr19_-_2783313 21.134 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr19_-_58874078 21.101 NM_001207009
NM_198458
ZNF497

zinc finger protein 497

chr16_-_72206348 21.078 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr1_+_84630374 21.071 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_116968986 20.911 NM_025164
SIK3
SIK family kinase 3
chr6_-_121655606 20.905 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr8_+_22462267 20.830 KIAA1967
KIAA1967
chr12_-_123459649 20.817 ABCB9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr19_-_2783225 20.811 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr8_+_22462532 20.706 NM_021174
KIAA1967
KIAA1967
chr19_-_59084735 20.678 MZF1
myeloid zinc finger 1
chr18_+_54318561 20.584 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr3_+_184056304 20.348 FAM131A
family with sequence similarity 131, member A
chr14_-_59932051 20.285 NM_022571
GPR135
G protein-coupled receptor 135
chr7_-_17980102 20.201 NM_015132
SNX13
sorting nexin 13
chr16_-_47494753 20.201 ITFG1
integrin alpha FG-GAP repeat containing 1
chr8_+_38243958 20.175 NM_001199659
NM_144652
LETM2

leucine zipper-EF-hand containing transmembrane protein 2

chr16_-_19729417 20.123 NM_001012991
C16orf88
chromosome 16 open reading frame 88
chr17_-_9862765 20.114 NM_003644
GAS7
growth arrest-specific 7
chr17_-_1532109 20.105 NM_152346
SLC43A2
solute carrier family 43, member 2
chr19_-_5680910 20.028 NM_205767
C19orf70
chromosome 19 open reading frame 70
chr6_+_35227234 20.008 ZNF76
zinc finger protein 76
chr11_-_71791734 19.938 NUMA1
nuclear mitotic apparatus protein 1
chr5_-_157098444 19.918 SOX30
SRY (sex determining region Y)-box 30
chr3_+_50306578 19.904 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr13_-_31736031 19.839 NM_006644
HSPH1
heat shock 105kDa/110kDa protein 1
chr1_-_156217717 19.807 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr3_-_13114547 19.581 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr1_+_169337193 19.491 NM_003666
BLZF1
basic leucine zipper nuclear factor 1
chr3_+_38080695 19.476 NM_007335
NM_007337
DLEC1

deleted in lung and esophageal cancer 1

chr19_-_375969 19.441 NM_016585
NM_199202
THEG

Theg homolog (mouse)

chr3_-_113233952 19.344 NM_144718
SPICE1
spindle and centriole associated protein 1
chr9_+_135753711 19.200 C9orf9
chromosome 9 open reading frame 9
chrX_+_135251454 19.067 NM_001159704
FHL1
four and a half LIM domains 1
chr5_-_132073143 18.950 NM_007054
KIF3A
kinesin family member 3A
chr7_-_4923246 18.901 NM_018059
RADIL
Ras association and DIL domains
chr12_+_2921786 18.828 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr16_-_47494981 18.763 NM_030790
ITFG1
integrin alpha FG-GAP repeat containing 1
chr19_-_2783332 18.679 NM_003021
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr17_-_16472463 18.664 NM_020653
ZNF287
zinc finger protein 287
chr4_-_156298094 18.614 NM_001039580
MAP9
microtubule-associated protein 9
chr13_-_73355969 18.583 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr8_+_94767071 18.515 NM_001142301
NM_153704
TMEM67

transmembrane protein 67

chr3_-_196439067 18.507 NM_032898
CEP19
centrosomal protein 19kDa
chr19_+_50879681 18.455 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr5_-_147162175 18.440 JAKMIP2
janus kinase and microtubule interacting protein 2
chr8_-_110704019 18.304 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr13_-_44361032 18.152 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr15_-_55700456 18.136 NM_004748
NM_001204450
NM_001204451
NM_020739
CCPG1



cell cycle progression 1



chr19_+_56652529 17.996 NM_001253792
NM_018337
ZNF444

zinc finger protein 444

chr3_+_196439211 17.859 NM_001166304
NM_017861
PIGX

phosphatidylinositol glycan anchor biosynthesis, class X

chr4_-_156297944 17.802 MAP9
microtubule-associated protein 9
chr2_+_173600595 17.802 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr17_-_1012257 17.780 NM_001092
ABR
active BCR-related gene
chr10_-_104178900 17.549 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr2_+_230787195 17.545 NM_174899
FBXO36
F-box protein 36

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.83 4.84e-04 GO:0042384 cilium assembly
6.20 1.62e-03 GO:0060271 cilium morphogenesis
4.59 2.77e-03 GO:0030031 cell projection assembly
2.01 2.83e-02 GO:0030030 cell projection organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.30 2.11e-07 GO:0005929 cilium
2.35 1.96e-06 GO:0015630 microtubule cytoskeleton
6.32 2.57e-05 GO:0005930 axoneme
1.23 3.30e-05 GO:0005737 cytoplasm
1.15 3.84e-05 GO:0005622 intracellular
1.15 6.15e-05 GO:0044424 intracellular part
2.93 6.64e-05 GO:0005874 microtubule
5.73 8.79e-05 GO:0044441 cilium part
6.56 5.56e-04 GO:0005932 microtubule basal body
15.66 1.76e-03 GO:0005952 cAMP-dependent protein kinase complex
2.44 3.94e-03 GO:0005815 microtubule organizing center
5.52 8.13e-03 GO:0019861 flagellum
10.84 1.60e-02 GO:0060170 cilium membrane
5.50 2.32e-02 GO:0035085 cilium axoneme
14.10 2.79e-02 GO:0034464 BBSome
3.60 3.41e-02 GO:0005875 microtubule associated complex
1.51 4.76e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.48 2.10e-02 GO:0017076 purine nucleotide binding
1.48 2.79e-02 GO:0032553 ribonucleotide binding
1.48 2.79e-02 GO:0032555 purine ribonucleotide binding