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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: RREB1.p2

Z-value: 4.022

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_-_54982271	66.310	NM_006741	PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr1_-_204380903	63.945	NM_032833	PPP1R15B	protein phosphatase 1, regulatory subunit 15B
chr4_-_5890142	60.184		CRMP1	collapsin response mediator protein 1
chr21_+_47649066	52.879		MCM3AP-AS1	MCM3AP antisense RNA 1 (non-protein coding)
chr10_-_135150474	52.339	NM_015722	CALY	calcyon neuron-specific vesicular protein
chr4_-_5890266	50.813	NM_001313	CRMP1	collapsin response mediator protein 1
chr7_+_64498643	48.290		CCT6P3	chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr17_+_42385780	47.972	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr11_-_125366048	47.721	NM_005103 NM_022549	FEZ1	fasciculation and elongation protein zeta 1 (zygin I)
chr19_+_3366589	47.184		NFIC	nuclear factor I/C (CCAAT-binding transcription factor)
chr19_+_35521591	45.128	NM_001037 NM_199037	SCN1B	sodium channel, voltage-gated, type I, beta
chr20_+_10199455	43.627	NM_003081 NM_130811	SNAP25	synaptosomal-associated protein, 25kDa
chrX_+_102632108	42.453	NM_014380	NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1
chr6_-_46459010	41.601	NM_001251974	RCAN2	regulator of calcineurin 2
chr11_-_134281725	41.469	NM_018644 NM_054025	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr10_-_135150368	41.054		CALY	calcyon neuron-specific vesicular protein
chr16_+_28834407	40.199	NM_007245 NM_145714 NM_148414 NM_148415 NM_148416	ATXN2L	ataxin 2-like
chr15_+_74422920	39.916		ISLR2	immunoglobulin superfamily containing leucine-rich repeat 2
chr6_-_29595746	39.317		GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1
chr16_+_28834372	38.371		ATXN2L	ataxin 2-like
chr16_+_28834565	37.745		ATXN2L	ataxin 2-like
chr21_-_47648685	37.111		LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr19_+_3366575	36.992		NFIC	nuclear factor I/C (CCAAT-binding transcription factor)
chr2_+_149633173	36.717
chr11_+_71791376	36.082	NM_001145307 NM_001145308 NM_001205138 NM_145309	LRTOMT	leucine rich transmembrane and 0-methyltransferase domain containing
chr12_+_79258517	36.044		SYT1	synaptotagmin I
chr1_-_156217717	35.922	NM_198406 NM_024897	PAQR6	progestin and adipoQ receptor family member VI
chr15_+_74422742	35.557	NM_020851	ISLR2	immunoglobulin superfamily containing leucine-rich repeat 2
chr16_+_28834360	35.264		ATXN2L	ataxin 2-like
chr11_-_72353435	33.337	NM_001143839 NM_001243784	PDE2A	phosphodiesterase 2A, cGMP-stimulated
chr1_+_46669005	33.018	NM_001013615	C1orf190	chromosome 1 open reading frame 190
chr14_-_21493858	33.017		NDRG2	NDRG family member 2
chr12_+_79258588	32.955		SYT1	synaptotagmin I
chr17_+_43971998	32.807		MAPT	microtubule-associated protein tau
chrX_+_102631408	32.546		NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1
chr6_-_29595934	30.697	NM_021903	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1
chrX_-_48693934	30.560	NM_013271	PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor
chr14_-_21493910	30.021	NM_016250 NM_201535 NM_201536 NM_201537	NDRG2	NDRG family member 2
chr2_-_218843541	30.012		TNS1	tensin 1
chr12_-_48152860	29.582	NM_001098531	RAPGEF3	Rap guanine nucleotide exchange factor (GEF) 3
chr8_+_58906968	29.442	NM_147189	FAM110B	family with sequence similarity 110, member B
chr7_+_95401817	29.394	NM_001135556 NM_001135557 NM_004411	DYNC1I1	dynein, cytoplasmic 1, intermediate chain 1
chr19_-_47975244	29.212	NM_015063	SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2
chrX_-_137793826	29.058	NM_004114	FGF13	fibroblast growth factor 13
chr7_-_767286	28.810	NM_001164758 NM_001164759	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta
chr1_-_20812727	28.595	NM_018584	CAMK2N1	calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_47975074	28.346		SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2
chr2_-_220173693	28.078	NM_001199764	PTPRN	protein tyrosine phosphatase, receptor type, N
chr19_+_56652689	27.995		ZNF444	zinc finger protein 444
chr19_-_49944613	27.834	NM_020309	SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr7_-_766875	27.215	NM_001164760	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta
chr15_+_64752778	27.176		ZNF609	zinc finger protein 609
chr13_-_37494370	26.911	NM_001127217 NM_005905	SMAD9	SMAD family member 9
chr17_-_1733083	26.368	NM_052928	SMYD4	SET and MYND domain containing 4
chr1_+_6845381	26.368	NM_001195563 NM_001242701 NM_015215	CAMTA1	calmodulin binding transcription activator 1
chr19_-_18314731	26.309	NM_002866	RAB3A	RAB3A, member RAS oncogene family
chr12_+_79258794	26.301		SYT1	synaptotagmin I
chr17_-_48207113	26.225	NM_174920	SAMD14	sterile alpha motif domain containing 14
chrX_+_103031433	26.017	NM_001128834	PLP1	proteolipid protein 1
chr1_+_1950745	25.831	NM_000815	GABRD	gamma-aminobutyric acid (GABA) A receptor, delta
chr12_-_16758312	25.785	NM_001243611	LMO3	LIM domain only 3 (rhombotin-like 2)
chr11_+_57365026	25.696	NM_000062	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_+_79258448	25.474	NM_005639	SYT1	synaptotagmin I
chr7_+_44144002	25.474		AEBP1	AE binding protein 1
chr7_+_44143945	25.275	NM_001129	AEBP1	AE binding protein 1
chrX_-_153881757	25.139	NM_020994 NM_172377	CTAG2	cancer/testis antigen 2
chr21_+_27011766	24.577		JAM2	junctional adhesion molecule 2
chr19_-_12721493	24.421	NM_020714	ZNF490	zinc finger protein 490
chrX_-_137793394	24.353		FGF13	fibroblast growth factor 13
chr11_-_73309090	24.187	NM_015159	FAM168A	family with sequence similarity 168, member A
chr16_+_56225301	24.044		GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr21_+_27012067	23.991		JAM2	junctional adhesion molecule 2
chr20_+_48599511	23.982	NM_005985	SNAI1	snail homolog 1 (Drosophila)
chr19_+_35629727	23.815	NM_021902	FXYD1	FXYD domain containing ion transport regulator 1
chr20_+_34742656	23.745	NM_012156	EPB41L1	erythrocyte membrane protein band 4.1-like 1
chr14_-_60097531	23.711	NM_206852	RTN1	reticulon 1
chr3_-_106959476	23.695
chr15_-_23086290	23.596	NM_144599	NIPA1	non imprinted in Prader-Willi/Angelman syndrome 1
chr19_+_56652529	23.374	NM_001253792 NM_018337	ZNF444	zinc finger protein 444
chr1_+_163041694	23.303	NM_001113380	RGS4	regulator of G-protein signaling 4
chr7_+_97910978	23.267	NM_001159491 NM_015379	BRI3	brain protein I3
chr15_+_74421698	23.246	NM_001130136	ISLR2	immunoglobulin superfamily containing leucine-rich repeat 2
chr19_-_6502224	23.111	NM_006087	TUBB4A	tubulin, beta 4A class IVa
chr14_-_60097223	23.024		RTN1	reticulon 1
chr3_-_10547340	22.845		ATP2B2	ATPase, Ca++ transporting, plasma membrane 2
chrX_+_103031753	22.761	NM_000533 NM_199478	PLP1	proteolipid protein 1
chr1_-_149889362	22.526	NM_014849	SV2A	synaptic vesicle glycoprotein 2A
chr12_-_49392909	22.365	NM_015086	DDN	dendrin
chr14_+_65007163	22.314	NM_021979	HSPA2	heat shock 70kDa protein 2
chr17_+_77751929	22.310	NM_005189 NM_032647	CBX2	chromobox homolog 2
chrY_-_16098319	22.176	NM_181880 NM_004679	VCY1B VCX3A VCY	variable charge, Y-linked 1B variable charge, X-linked 3A variable charge, Y-linked
chr11_-_1016736	22.012		MUC6	mucin 6, oligomeric mucus/gel-forming
chrY_-_1281526	21.936	NM_001012288 NM_022148	CRLF2	cytokine receptor-like factor 2
chr7_-_143059144	21.935	NM_014690	FAM131B	family with sequence similarity 131, member B
chr3_+_238535	21.832		CHL1	cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr12_+_70759974	21.784	NM_014505	KCNMB4	potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr19_+_3366536	21.775	NM_001245002 NM_001245004 NM_005597	NFIC	nuclear factor I/C (CCAAT-binding transcription factor)
chr14_-_60097314	21.642		RTN1	reticulon 1
chr1_+_955536	21.488
chr8_+_94929082	21.435	NM_018444 NM_001161780 NM_001161779 NM_001161781	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1
chr11_-_17498419	21.416	NM_000352	ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr6_+_7108864	21.353		RREB1	ras responsive element binding protein 1
chr17_+_43972014	21.316		MAPT	microtubule-associated protein tau
chr3_+_58223228	21.291	NM_020676	ABHD6	abhydrolase domain containing 6
chr22_-_44258210	21.226	NM_014351	SULT4A1	sulfotransferase family 4A, member 1
chrX_+_38420690	21.201	NM_004615	TSPAN7	tetraspanin 7
chr21_+_27012045	21.091		JAM2	junctional adhesion molecule 2
chr12_-_53448167	21.040		LOC283335	uncharacterized LOC283335
chr5_+_175792444	21.009	NM_173664	ARL10	ADP-ribosylation factor-like 10
chr19_+_708766	20.763	NM_001040134 NM_002579	PALM	paralemmin
chr14_+_29236171	20.678	NM_005249	FOXG1	forkhead box G1
chr19_-_55866063	20.656	NM_144613	COX6B2	cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr3_-_10547267	20.641	NM_001001331 NM_001683	ATP2B2	ATPase, Ca++ transporting, plasma membrane 2
chr9_-_101470836	20.541	NM_005458	GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2
chr17_+_7554711	20.390		ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide
chr13_+_45915479	20.329		LOC100190939	uncharacterized LOC100190939
chr9_+_132427919	20.274	NM_016307	PRRX2	paired related homeobox 2
chr14_-_21493122	20.163	NM_201538 NM_201539 NM_201540 NM_201541	NDRG2	NDRG family member 2
chr5_-_132298973	20.156		AFF4	AF4/FMR2 family, member 4
chr11_+_57365577	20.133	NM_001032295	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr19_+_35634153	20.128	NM_022006	FXYD7	FXYD domain containing ion transport regulator 7
chr14_+_100438095	19.980		EVL	Enah/Vasp-like
chrX_-_135333519	19.902	NM_001173517 NM_024597	MAP7D3	MAP7 domain containing 3
chr22_+_51039178	19.879		MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2
chr1_+_21835915	19.791		ALPL	alkaline phosphatase, liver/bone/kidney
chr2_+_231729623	19.734		ITM2C	integral membrane protein 2C
chr11_-_119293848	19.660		THY1	Thy-1 cell surface antigen
chr8_+_41685789	19.600
chr16_+_50186809	19.581	NM_001040284 NM_001040285	PAPD5	PAP associated domain containing 5
chr19_-_5340700	19.446	NM_002850 NM_130853 NM_130854 NM_130855	PTPRS	protein tyrosine phosphatase, receptor type, S
chr18_-_29522988	19.361		TRAPPC8	trafficking protein particle complex 8
chrY_+_16168097	19.337	NM_181880 NM_004679	VCY1B VCX3A VCY	variable charge, Y-linked 1B variable charge, X-linked 3A variable charge, Y-linked
chr7_+_65338161	19.229	NM_173517	VKORC1L1	vitamin K epoxide reductase complex, subunit 1-like 1
chr12_-_48152180	19.213	NM_001098532 NM_006105	RAPGEF3	Rap guanine nucleotide exchange factor (GEF) 3
chr2_-_128432642	19.184	NM_001136037 NM_001161403	LIMS2	LIM and senescent cell antigen-like domains 2
chr15_-_88799961	19.086	NM_001007156 NM_001012338 NM_001243101 NM_002530	NTRK3	neurotrophic tyrosine kinase, receptor, type 3
chr17_-_79139871	18.890	NM_001080395	AATK	apoptosis-associated tyrosine kinase
chr11_-_113746205	18.832	NM_020886	USP28	ubiquitin specific peptidase 28
chr12_+_123717843	18.790	NM_152269 NM_001194995	C12orf65	chromosome 12 open reading frame 65
chrX_-_151306959	18.776	NM_001204811 NM_001011543 NM_001251828 NM_021048	MAGEA10-MAGEA5 MAGEA10	MAGEA10-MAGEA5 readthrough melanoma antigen family A, 10
chr3_-_42003460	18.765	NM_017886	ULK4	unc-51-like kinase 4 (C. elegans)
chr2_+_231729501	18.709	NM_001012514 NM_001012516 NM_030926	ITM2C	integral membrane protein 2C
chr10_+_134145597	18.692	NM_001143758 NM_001143759 NM_030626	LRRC27	leucine rich repeat containing 27
chr17_-_27278324	18.648		PHF12	PHD finger protein 12
chr10_-_69835042	18.541	NM_015601 NM_022079	HERC4	hect domain and RLD 4
chr5_-_142065586	18.252	NM_000800	FGF1	fibroblast growth factor 1 (acidic)
chr16_+_67198678	18.066		HSF4	heat shock transcription factor 4
chr2_-_220174058	18.040		PTPRN	protein tyrosine phosphatase, receptor type, N
chr16_+_67198637	18.028		HSF4	heat shock transcription factor 4
chr21_-_47648672	18.008		LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr10_+_21823573	17.965	NM_001195626	MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr8_+_104152876	17.858	NM_001024372 NM_024812	BAALC	brain and acute leukemia, cytoplasmic
chr7_-_158380360	17.847	NM_002847 NM_130842 NM_130843	PTPRN2	protein tyrosine phosphatase, receptor type, N polypeptide 2
chr16_-_4588379	17.716	NM_001199054	C16orf5	chromosome 16 open reading frame 5
chr22_+_51039100	17.662	NM_012324	MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2
chr14_+_96505566	17.652	NM_001252507	C14orf132	chromosome 14 open reading frame 132
chrX_+_101906293	17.631	NM_001099410 NM_001099411 NM_014710 NM_001184727	GPRASP1	G protein-coupled receptor associated sorting protein 1
chrX_-_1331526	17.533	NM_001012288 NM_022148	CRLF2	cytokine receptor-like factor 2
chr2_-_145274916	17.439		ZEB2	zinc finger E-box binding homeobox 2
chr9_+_130374466	17.391	NM_001032221 NM_003165	STXBP1	syntaxin binding protein 1
chrX_+_135229536	17.381	NM_001159702 NM_001159703 NM_001449	FHL1	four and a half LIM domains 1
chr12_+_6930689	17.325	NM_014449 NM_019858	GPR162	G protein-coupled receptor 162
chr16_+_2039945	17.300	NM_004209	SYNGR3	synaptogyrin 3
chrX_+_152224862	17.142		PNMA3	paraneoplastic antigen MA3
chr14_+_92789536	17.047	NM_153647	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr19_-_36246411	17.024		HSPB6	heat shock protein, alpha-crystallin-related, B6
chr9_+_139560243	16.967		EGFL7	EGF-like-domain, multiple 7
chr1_+_33352071	16.866	NM_002143	HPCA	hippocalcin
chr12_-_49504612	16.862		LMBR1L	limb region 1 homolog (mouse)-like
chr5_-_136834887	16.771	NM_004598	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr21_-_47648715	16.741	NM_001001438 NM_001145436 NM_001145437 NM_002340	LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr16_-_3285069	16.737	NM_001145447 NM_003454	ZNF200	zinc finger protein 200
chr19_-_6720585	16.713	NM_000064	C3	complement component 3
chr2_+_48757063	16.624	NM_001198593	STON1-GTF2A1L	STON1-GTF2A1L readthrough
chr11_+_119077021	16.597		CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr1_+_3388170	16.568		ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16
chr8_-_22550708	16.563	NM_004430	EGR3	early growth response 3
chr3_-_52001388	16.535	NM_020418 NM_001174100 NM_033008	PCBP4	poly(rC) binding protein 4
chr16_+_50099907	16.516		HEATR3	HEAT repeat containing 3
chr16_-_71842539	16.497		AP1G1	adaptor-related protein complex 1, gamma 1 subunit
chr2_+_26915390	16.314	NM_002246	KCNK3	potassium channel, subfamily K, member 3
chr14_+_94640648	16.195	NM_020958 NM_058237	PPP4R4	protein phosphatase 4, regulatory subunit 4
chr11_+_45907198	16.160		MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr21_-_47648618	16.154		LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr22_+_24373107	16.101	NM_001144931	LOC391322	D-dopachrome tautomerase-like
chr10_-_104178569	16.075		PSD	pleckstrin and Sec7 domain containing
chr19_-_38800508	16.074	NM_033557	YIF1B	Yip1 interacting factor homolog B (S. cerevisiae)
chr16_-_28303366	16.005
chr10_-_69835012	15.906		HERC4	hect domain and RLD 4
chr3_+_49449753	15.869		TCTA	T-cell leukemia translocation altered gene
chr12_+_4918341	15.841	NM_002235	KCNA6	potassium voltage-gated channel, shaker-related subfamily, member 6
chr2_-_220174201	15.836	NM_001199763 NM_002846	PTPRN	protein tyrosine phosphatase, receptor type, N
chr17_+_29718777	15.797		RAB11FIP4	RAB11 family interacting protein 4 (class II)
chr13_-_41240607	15.741	NM_002015	FOXO1	forkhead box O1
chr5_-_77590466	15.695		AP3B1	adaptor-related protein complex 3, beta 1 subunit
chr15_+_68871285	15.630	NM_006091	CORO2B	coronin, actin binding protein, 2B
chr2_+_231729638	15.592		ITM2C	integral membrane protein 2C
chr6_-_167275997	15.486		RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_226111977	15.439		PYCR2	pyrroline-5-carboxylate reductase family, member 2
chr14_-_101034261	15.431	NM_001159531	BEGAIN	brain-enriched guanylate kinase-associated homolog (rat)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.51	3.50e-35	GO:0048856	anatomical structure development
1.45	2.15e-34	GO:0032502	developmental process
1.47	1.60e-33	GO:0007275	multicellular organismal development
1.25	3.15e-33	GO:0065007	biological regulation
1.53	3.54e-33	GO:0048731	system development
1.76	1.54e-31	GO:0007399	nervous system development
1.56	6.30e-26	GO:0048869	cellular developmental process
1.57	1.26e-25	GO:0030154	cell differentiation
1.23	5.50e-25	GO:0050789	regulation of biological process
1.24	2.51e-24	GO:0050794	regulation of cellular process
1.29	2.92e-23	GO:0032501	multicellular organismal process
1.55	7.74e-22	GO:0048513	organ development
1.62	4.98e-21	GO:0009653	anatomical structure morphogenesis
1.34	1.10e-19	GO:0023052	signaling
1.79	1.12e-19	GO:0048468	cell development
1.78	3.37e-19	GO:0022008	neurogenesis
1.90	6.75e-19	GO:0030182	neuron differentiation
1.80	7.21e-19	GO:0048699	generation of neurons
2.08	1.49e-18	GO:0019226	transmission of nerve impulse
2.08	1.49e-18	GO:0035637	multicellular organismal signaling
1.83	9.50e-18	GO:0007267	cell-cell signaling
1.71	1.26e-17	GO:0007154	cell communication
1.12	2.03e-17	GO:0009987	cellular process
2.01	1.15e-16	GO:0007417	central nervous system development
2.08	3.58e-16	GO:0007268	synaptic transmission
1.44	8.64e-16	GO:0048523	negative regulation of cellular process
1.58	1.66e-15	GO:0051239	regulation of multicellular organismal process
1.88	5.07e-15	GO:0009887	organ morphogenesis
1.40	7.01e-15	GO:0048519	negative regulation of biological process
1.69	1.61e-14	GO:0050793	regulation of developmental process
1.78	1.43e-13	GO:0045595	regulation of cell differentiation
1.28	3.90e-13	GO:0019222	regulation of metabolic process
1.82	2.91e-12	GO:0048666	neuron development
2.04	4.15e-12	GO:0007420	brain development
1.60	4.80e-12	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.34	5.79e-12	GO:0048518	positive regulation of biological process
1.34	8.42e-12	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.69	1.45e-11	GO:2000026	regulation of multicellular organismal development
1.73	1.59e-11	GO:0010628	positive regulation of gene expression
1.37	2.77e-11	GO:0065008	regulation of biological quality
1.27	7.85e-11	GO:0080090	regulation of primary metabolic process
1.27	9.31e-11	GO:0031323	regulation of cellular metabolic process
1.32	1.10e-10	GO:0031326	regulation of cellular biosynthetic process
1.28	1.14e-10	GO:0007165	signal transduction
1.36	1.22e-10	GO:0006355	regulation of transcription, DNA-dependent
1.32	1.25e-10	GO:0009889	regulation of biosynthetic process
1.57	1.36e-10	GO:0032879	regulation of localization
1.79	1.59e-10	GO:0045892	negative regulation of transcription, DNA-dependent
1.31	1.93e-10	GO:0051171	regulation of nitrogen compound metabolic process
1.78	2.12e-10	GO:0051253	negative regulation of RNA metabolic process
1.82	2.17e-10	GO:0000904	cell morphogenesis involved in differentiation
1.34	2.40e-10	GO:0048522	positive regulation of cellular process
1.32	3.64e-10	GO:0010468	regulation of gene expression
1.72	1.22e-09	GO:0000902	cell morphogenesis
1.34	1.85e-09	GO:0051252	regulation of RNA metabolic process
1.26	2.17e-09	GO:0060255	regulation of macromolecule metabolic process
1.69	2.25e-09	GO:0051172	negative regulation of nitrogen compound metabolic process
1.70	2.99e-09	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40	4.08e-09	GO:0023051	regulation of signaling
1.68	4.09e-09	GO:0032989	cellular component morphogenesis
1.56	5.88e-09	GO:0006351	transcription, DNA-dependent
1.69	6.94e-09	GO:0010629	negative regulation of gene expression
1.76	1.02e-08	GO:0031175	neuron projection development
1.64	1.28e-08	GO:0031327	negative regulation of cellular biosynthetic process
1.67	1.30e-08	GO:0045893	positive regulation of transcription, DNA-dependent
1.81	1.40e-08	GO:0048667	cell morphogenesis involved in neuron differentiation
1.55	2.19e-08	GO:0009888	tissue development
1.79	2.40e-08	GO:0048812	neuron projection morphogenesis
1.81	2.40e-08	GO:0007409	axonogenesis
1.22	2.66e-08	GO:0051716	cellular response to stimulus
2.29	3.02e-08	GO:0030900	forebrain development
1.61	4.55e-08	GO:0009890	negative regulation of biosynthetic process
1.30	5.41e-08	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.31	5.43e-08	GO:0042221	response to chemical stimulus
1.58	5.92e-08	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.62	5.98e-08	GO:0051254	positive regulation of RNA metabolic process
1.91	7.84e-08	GO:0051093	negative regulation of developmental process
1.29	9.17e-08	GO:0010556	regulation of macromolecule biosynthetic process
2.63	9.49e-08	GO:0006836	neurotransmitter transport
1.74	1.03e-07	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.63	1.12e-07	GO:0030030	cell projection organization
1.56	1.60e-07	GO:0051173	positive regulation of nitrogen compound metabolic process
1.52	2.73e-07	GO:0009891	positive regulation of biosynthetic process
1.89	3.01e-07	GO:0060284	regulation of cell development
1.52	3.65e-07	GO:0040011	locomotion
1.56	4.70e-07	GO:0010557	positive regulation of macromolecule biosynthetic process
1.34	5.13e-07	GO:0007166	cell surface receptor linked signaling pathway
1.61	5.16e-07	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.85	5.27e-07	GO:0044057	regulation of system process
1.78	5.94e-07	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
1.41	6.87e-07	GO:0009893	positive regulation of metabolic process
1.68	7.82e-07	GO:0048858	cell projection morphogenesis
1.59	8.51e-07	GO:0010558	negative regulation of macromolecule biosynthetic process
1.51	9.59e-07	GO:0031328	positive regulation of cellular biosynthetic process
2.39	1.11e-06	GO:0010769	regulation of cell morphogenesis involved in differentiation
2.90	1.25e-06	GO:0050770	regulation of axonogenesis
2.99	1.34e-06	GO:0007269	neurotransmitter secretion
1.67	1.48e-06	GO:0032990	cell part morphogenesis
2.37	1.57e-06	GO:0022604	regulation of cell morphogenesis
1.32	1.87e-06	GO:0048583	regulation of response to stimulus
1.91	4.05e-06	GO:0045596	negative regulation of cell differentiation
1.41	4.18e-06	GO:0010604	positive regulation of macromolecule metabolic process
1.37	4.43e-06	GO:0009966	regulation of signal transduction
2.60	4.76e-06	GO:0001505	regulation of neurotransmitter levels
1.38	5.35e-06	GO:0035556	intracellular signal transduction
1.87	5.84e-06	GO:0007423	sensory organ development
1.88	5.97e-06	GO:0051960	regulation of nervous system development
1.58	6.10e-06	GO:0048878	chemical homeostasis
2.48	6.63e-06	GO:0021700	developmental maturation
1.44	7.33e-06	GO:0009892	negative regulation of metabolic process
1.44	7.50e-06	GO:0009605	response to external stimulus
1.83	7.68e-06	GO:0022603	regulation of anatomical structure morphogenesis
1.68	7.76e-06	GO:0051094	positive regulation of developmental process
1.43	8.08e-06	GO:0010646	regulation of cell communication
2.78	9.78e-06	GO:0048638	regulation of developmental growth
1.46	1.38e-05	GO:0031324	negative regulation of cellular metabolic process
1.65	1.55e-05	GO:0072358	cardiovascular system development
1.65	1.55e-05	GO:0072359	circulatory system development
2.10	2.61e-05	GO:0006936	muscle contraction
1.43	2.81e-05	GO:0032774	RNA biosynthetic process
1.14	3.35e-05	GO:0050896	response to stimulus
1.65	5.44e-05	GO:0006873	cellular ion homeostasis
1.64	6.08e-05	GO:0055082	cellular chemical homeostasis
1.99	6.45e-05	GO:0048732	gland development
1.37	7.04e-05	GO:0031325	positive regulation of cellular metabolic process
1.62	7.26e-05	GO:0050801	ion homeostasis
2.32	8.03e-05	GO:0003001	generation of a signal involved in cell-cell signaling
2.32	8.03e-05	GO:0023061	signal release
1.42	1.57e-04	GO:0010605	negative regulation of macromolecule metabolic process
2.18	1.67e-04	GO:0030799	regulation of cyclic nucleotide metabolic process
1.84	1.72e-04	GO:0050767	regulation of neurogenesis
1.71	2.00e-04	GO:0007411	axon guidance
2.19	2.07e-04	GO:0030802	regulation of cyclic nucleotide biosynthetic process
2.19	2.07e-04	GO:0030808	regulation of nucleotide biosynthetic process
1.71	2.37e-04	GO:0045597	positive regulation of cell differentiation
2.58	2.75e-04	GO:0048469	cell maturation
1.61	3.21e-04	GO:0032583	regulation of gene-specific transcription
1.93	3.28e-04	GO:0007517	muscle organ development
1.96	3.30e-04	GO:0003012	muscle system process
2.32	3.46e-04	GO:0045761	regulation of adenylate cyclase activity
1.29	4.19e-04	GO:0003008	system process
1.48	4.28e-04	GO:0009719	response to endogenous stimulus
1.74	4.72e-04	GO:0051270	regulation of cellular component movement
1.43	4.83e-04	GO:0051128	regulation of cellular component organization
1.50	5.47e-04	GO:0009725	response to hormone stimulus
1.18	5.89e-04	GO:0051179	localization
2.28	6.65e-04	GO:0031279	regulation of cyclase activity
1.31	7.54e-04	GO:0065009	regulation of molecular function
2.04	7.66e-04	GO:0001655	urogenital system development
1.74	7.77e-04	GO:0061061	muscle structure development
2.16	1.18e-03	GO:0030817	regulation of cAMP biosynthetic process
1.87	1.20e-03	GO:0045664	regulation of neuron differentiation
2.23	1.25e-03	GO:0051339	regulation of lyase activity
1.63	1.37e-03	GO:0048598	embryonic morphogenesis
1.44	1.55e-03	GO:0051049	regulation of transport
2.14	1.58e-03	GO:0030814	regulation of cAMP metabolic process
1.52	2.17e-03	GO:0006935	chemotaxis
1.52	2.17e-03	GO:0042330	taxis
1.78	2.19e-03	GO:0032101	regulation of response to external stimulus
1.62	2.43e-03	GO:0010551	regulation of gene-specific transcription from RNA polymerase II promoter
1.44	3.00e-03	GO:0009790	embryo development
1.61	3.03e-03	GO:0090066	regulation of anatomical structure size
1.18	3.14e-03	GO:0016043	cellular component organization
1.97	3.30e-03	GO:0045165	cell fate commitment
3.22	3.66e-03	GO:0030516	regulation of axon extension
1.56	3.67e-03	GO:0040008	regulation of growth
1.75	4.57e-03	GO:0003002	regionalization
1.51	4.78e-03	GO:0048585	negative regulation of response to stimulus
1.95	5.26e-03	GO:0031344	regulation of cell projection organization
1.63	5.56e-03	GO:0032535	regulation of cellular component size
3.91	5.60e-03	GO:0042551	neuron maturation
1.70	5.64e-03	GO:0001568	blood vessel development
1.71	6.29e-03	GO:0008361	regulation of cell size
1.61	6.51e-03	GO:0007389	pattern specification process
1.55	7.19e-03	GO:0016477	cell migration
1.53	7.28e-03	GO:0046903	secretion
1.70	7.44e-03	GO:0030334	regulation of cell migration
1.77	8.23e-03	GO:0048514	blood vessel morphogenesis
1.40	8.80e-03	GO:0007155	cell adhesion
1.40	8.80e-03	GO:0022610	biological adhesion
2.30	9.01e-03	GO:0021953	central nervous system neuron differentiation
1.47	9.89e-03	GO:0019725	cellular homeostasis
3.43	1.00e-02	GO:0071300	cellular response to retinoic acid
1.63	1.04e-02	GO:0007610	behavior
1.36	1.22e-02	GO:0042592	homeostatic process
1.68	1.22e-02	GO:2000145	regulation of cell motility
1.88	1.26e-02	GO:0006813	potassium ion transport
2.00	1.30e-02	GO:0010975	regulation of neuron projection development
2.34	1.35e-02	GO:0010721	negative regulation of cell development
1.64	1.44e-02	GO:0001944	vasculature development
1.64	1.44e-02	GO:0040012	regulation of locomotion
2.09	1.46e-02	GO:0010720	positive regulation of cell development
1.59	1.52e-02	GO:0003006	developmental process involved in reproduction
1.95	1.67e-02	GO:0060191	regulation of lipase activity
1.39	1.73e-02	GO:0006468	protein phosphorylation
1.71	1.81e-02	GO:0051129	negative regulation of cellular component organization
1.86	1.92e-02	GO:0009952	anterior/posterior pattern formation
2.05	1.97e-02	GO:0072001	renal system development
3.30	1.98e-02	GO:0071299	cellular response to vitamin A
1.49	2.10e-02	GO:0048646	anatomical structure formation involved in morphogenesis
3.15	2.11e-02	GO:0048639	positive regulation of developmental growth
1.41	2.12e-02	GO:0007167	enzyme linked receptor protein signaling pathway
1.64	2.22e-02	GO:0055065	metal ion homeostasis
1.48	2.26e-02	GO:0030001	metal ion transport
2.22	2.32e-02	GO:0008016	regulation of heart contraction
1.35	2.38e-02	GO:0006811	ion transport
2.49	2.39e-02	GO:0040014	regulation of multicellular organism growth
1.17	2.54e-02	GO:0051234	establishment of localization
2.27	2.60e-02	GO:0033189	response to vitamin A
1.59	2.86e-02	GO:0051046	regulation of secretion
1.60	3.27e-02	GO:0048729	tissue morphogenesis
1.59	3.28e-02	GO:0006140	regulation of nucleotide metabolic process
1.97	3.34e-02	GO:0033273	response to vitamin
2.36	3.42e-02	GO:0032526	response to retinoic acid
3.93	3.57e-02	GO:0021879	forebrain neuron differentiation
3.18	3.73e-02	GO:0050771	negative regulation of axonogenesis
1.84	3.74e-02	GO:0048562	embryonic organ morphogenesis
1.44	3.86e-02	GO:0006928	cellular component movement
1.75	4.03e-02	GO:0032582	negative regulation of gene-specific transcription
2.38	4.15e-02	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
1.99	4.17e-02	GO:0043583	ear development
1.92	4.19e-02	GO:0048705	skeletal system morphogenesis
1.63	4.23e-02	GO:0006875	cellular metal ion homeostasis
1.81	4.29e-02	GO:0001654	eye development
1.48	4.35e-02	GO:0048870	cell motility
1.48	4.35e-02	GO:0051674	localization of cell
1.73	4.59e-02	GO:0003013	circulatory system process
1.73	4.59e-02	GO:0008015	blood circulation
2.52	4.94e-02	GO:0001764	neuron migration

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.47	6.97e-21	GO:0044459	plasma membrane part
1.92	5.89e-12	GO:0045202	synapse
1.49	2.46e-11	GO:0005887	integral to plasma membrane
1.48	3.53e-11	GO:0031226	intrinsic to plasma membrane
1.21	6.02e-09	GO:0005886	plasma membrane
1.21	1.32e-08	GO:0071944	cell periphery
1.62	2.71e-08	GO:0030054	cell junction
1.44	3.27e-08	GO:0000267	cell fraction
1.89	6.00e-08	GO:0044456	synapse part
2.03	1.49e-07	GO:0034702	ion channel complex
1.72	4.79e-07	GO:0043005	neuron projection
2.24	9.53e-07	GO:0034703	cation channel complex
1.71	1.94e-06	GO:0031012	extracellular matrix
1.46	2.08e-06	GO:0005626	insoluble fraction
1.46	5.06e-06	GO:0005624	membrane fraction
2.62	1.30e-05	GO:0042383	sarcolemma
2.37	7.79e-05	GO:0008076	voltage-gated potassium channel complex
2.37	7.79e-05	GO:0034705	potassium channel complex
1.68	8.98e-05	GO:0005578	proteinaceous extracellular matrix
1.97	2.61e-04	GO:0045211	postsynaptic membrane
1.42	2.72e-04	GO:0016023	cytoplasmic membrane-bounded vesicle
1.38	3.69e-04	GO:0042995	cell projection
1.41	3.80e-04	GO:0031988	membrane-bounded vesicle
3.02	8.46e-04	GO:0005581	collagen
2.14	1.05e-03	GO:0019717	synaptosome
1.32	1.47e-03	GO:0044421	extracellular region part
1.37	1.55e-03	GO:0031982	vesicle
1.38	1.61e-03	GO:0031410	cytoplasmic vesicle
1.58	2.71e-03	GO:0044433	cytoplasmic vesicle part
1.81	4.28e-03	GO:0030136	clathrin-coated vesicle
1.97	5.29e-03	GO:0044420	extracellular matrix part
1.45	2.66e-02	GO:0044463	cell projection part
1.50	2.77e-02	GO:0005625	soluble fraction
2.02	3.34e-02	GO:0030665	clathrin coated vesicle membrane
1.05	4.06e-02	GO:0005622	intracellular

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.75	4.02e-21	GO:0001071	nucleic acid binding transcription factor activity
1.75	4.02e-21	GO:0003700	sequence-specific DNA binding transcription factor activity
1.89	3.04e-19	GO:0043565	sequence-specific DNA binding
1.18	1.26e-15	GO:0005515	protein binding
1.59	3.07e-13	GO:0030528	transcription regulator activity
1.09	1.27e-12	GO:0005488	binding
1.95	5.17e-08	GO:0005261	cation channel activity
2.30	1.70e-07	GO:0022843	voltage-gated cation channel activity
2.07	1.72e-07	GO:0000975	regulatory region DNA binding
2.07	1.72e-07	GO:0001067	regulatory region nucleic acid binding
2.07	1.72e-07	GO:0044212	transcription regulatory region DNA binding
1.74	2.03e-07	GO:0022838	substrate-specific channel activity
1.74	3.20e-07	GO:0005216	ion channel activity
1.84	3.23e-07	GO:0022836	gated channel activity
1.72	3.68e-07	GO:0015267	channel activity
1.72	4.37e-07	GO:0022803	passive transmembrane transporter activity
2.03	1.19e-06	GO:0010843	promoter binding
1.27	1.52e-06	GO:0003677	DNA binding
1.47	1.65e-05	GO:0019899	enzyme binding
2.14	1.87e-05	GO:0005516	calmodulin binding
1.93	6.52e-05	GO:0005244	voltage-gated ion channel activity
1.93	6.52e-05	GO:0022832	voltage-gated channel activity
1.44	1.03e-04	GO:0015075	ion transmembrane transporter activity
1.69	1.22e-04	GO:0016563	transcription activator activity
2.80	2.54e-04	GO:0003707	steroid hormone receptor activity
2.09	2.81e-04	GO:0005267	potassium channel activity
1.47	8.36e-04	GO:0008324	cation transmembrane transporter activity
2.65	9.99e-04	GO:0004879	ligand-dependent nuclear receptor activity
2.16	1.58e-03	GO:0005249	voltage-gated potassium channel activity
1.36	1.91e-03	GO:0022891	substrate-specific transmembrane transporter activity
1.34	2.06e-03	GO:0022857	transmembrane transporter activity
1.30	2.41e-03	GO:0005215	transporter activity
2.59	2.68e-03	GO:0016247	channel regulator activity
3.30	4.95e-03	GO:0005245	voltage-gated calcium channel activity
1.31	6.79e-03	GO:0022892	substrate-specific transporter activity
1.85	9.62e-03	GO:0003714	transcription corepressor activity
1.47	1.13e-02	GO:0019904	protein domain specific binding
1.30	1.42e-02	GO:0005102	receptor binding
3.06	1.68e-02	GO:0017046	peptide hormone binding
1.38	1.73e-02	GO:0046983	protein dimerization activity
1.46	1.84e-02	GO:0042803	protein homodimerization activity
1.35	1.85e-02	GO:0042802	identical protein binding
1.88	2.55e-02	GO:0015276	ligand-gated ion channel activity
1.88	2.55e-02	GO:0022834	ligand-gated channel activity
1.54	2.57e-02	GO:0016564	transcription repressor activity
1.43	3.05e-02	GO:0060589	nucleoside-triphosphatase regulator activity
1.43	3.86e-02	GO:0030695	GTPase regulator activity
1.54	4.48e-02	GO:0008134	transcription factor binding