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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: SPI1.p2

Z-value: 4.202

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_-_153518265	59.426	NM_002961 NM_019554	S100A4	S100 calcium binding protein A4
chr1_+_26644458	51.606		CD52	CD52 molecule
chr11_-_46142955	51.341	NM_001101802 NM_016621	PHF21A	PHD finger protein 21A
chr16_-_88717395	47.078	NM_000101	CYBA	cytochrome b-245, alpha polypeptide
chr21_-_46340821	44.407		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr22_+_37257004	44.255	NM_000631 NM_013416	NCF4	neutrophil cytosolic factor 4, 40kDa
chr6_-_31704272	43.958		CLIC1	chloride intracellular channel 1
chr15_+_75074714	42.427		CSK	c-src tyrosine kinase
chrX_+_48542159	40.855	NM_000377	WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr6_-_32160289	40.716		GPSM3	G-protein signaling modulator 3
chr19_+_35645614	40.233	NM_014164	FXYD5	FXYD domain containing ion transport regulator 5
chr1_-_31230673	39.446	NM_006762	LAPTM5	lysosomal protein transmembrane 5
chr5_+_118691692	39.015		TNFAIP8	tumor necrosis factor, alpha-induced protein 8
chrX_-_47489243	38.903	NM_001145252	CFP	complement factor properdin
chr19_+_35645640	37.902	NM_144779 NM_001164605	FXYD5	FXYD domain containing ion transport regulator 5
chr6_-_31704070	37.884		CLIC1	chloride intracellular channel 1
chr10_-_88281486	37.827		WAPAL	wings apart-like homolog (Drosophila)
chrX_-_47489703	36.895	NM_002621	CFP	complement factor properdin
chr15_+_75074417	35.900	NM_001127190 NM_004383	CSK	c-src tyrosine kinase
chr19_+_49838700	35.649		CD37	CD37 molecule
chr10_-_27149892	35.422		ABI1	abl-interactor 1
chr10_-_27149791	35.201		ABI1	abl-interactor 1
chr6_-_31704093	35.155		CLIC1	chloride intracellular channel 1
chr19_-_10450262	35.019	NM_002162	ICAM3	intercellular adhesion molecule 3
chr4_-_185395616	33.114	NM_002199	IRF2	interferon regulatory factor 2
chr20_+_43514340	31.658	NM_003404 NM_139323	YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr6_-_32812711	31.023	NM_004159	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr6_-_32812409	30.909		PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr9_+_131451823	30.908		SET	SET nuclear oncogene
chr6_-_31704287	30.872		CLIC1	chloride intracellular channel 1
chr1_-_153363544	30.806	NM_002964	S100A8	S100 calcium binding protein A8
chr1_-_111743297	30.439		DENND2D	DENN/MADD domain containing 2D
chrX_-_118827060	30.334		SEPT6	septin 6
chr6_-_31704318	30.119	NM_001288	CLIC1	chloride intracellular channel 1
chr2_+_109237679	29.285	NM_001193484	LIMS1	LIM and senescent cell antigen-like domains 1
chr20_+_3776905	29.245		CDC25B	cell division cycle 25 homolog B (S. pombe)
chr21_-_46340874	28.486	NM_000211	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_-_31550065	28.337	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr7_-_86848818	28.203	NM_024315	C7orf23	chromosome 7 open reading frame 23
chr8_+_22437983	28.133	NM_176871 NM_198042	PDLIM2	PDZ and LIM domain 2 (mystique)
chr21_-_46340776	27.601		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_+_25205180	27.537	NM_001204126 NM_001204127 NM_006152	LRMP	lymphoid-restricted membrane protein
chr14_-_23288912	27.396	NM_001126106	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_-_58343308	27.265	NM_004811	LPXN	leupaxin
chr12_-_51717835	27.264		BIN2	bridging integrator 2
chr19_-_8642297	27.202		MYO1F	myosin IF
chr12_-_51717905	27.045	NM_016293	BIN2	bridging integrator 2
chr12_-_51717941	26.939		BIN2	bridging integrator 2
chr14_-_35344450	26.802		BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr2_+_219082119	26.759	NM_005731	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr2_-_32235805	26.651		MEMO1	mediator of cell motility 1
chr12_+_7060554	26.633		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr6_-_32812189	26.576		PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr11_-_102323353	26.205	NM_052932	TMEM123	transmembrane protein 123
chr1_-_150241409	26.202	NM_001077628 NM_001243771 NM_001243772 NM_016022	APH1A	anterior pharynx defective 1 homolog A (C. elegans)
chr14_-_35344080	26.086		BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr17_-_29641094	26.030	NM_006495	EVI2B	ecotropic viral integration site 2B
chr17_-_4851688	25.996		PFN1	profilin 1
chr19_+_49838673	25.605	NM_001040031 NM_001774	CD37	CD37 molecule
chr1_+_111415791	25.352		CD53	CD53 molecule
chr16_+_30194730	25.326	NM_001193333 NM_007074	CORO1A	coronin, actin binding protein, 1A
chr6_-_32811773	25.166	NM_148919	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr2_+_85198431	25.047		KCMF1	potassium channel modulatory factor 1
chr15_-_65282093	24.961		SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr2_+_219081864	24.737	NM_152862	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr17_+_65822206	24.704		BPTF	bromodomain PHD finger transcription factor
chr2_-_61697899	24.350		USP34	ubiquitin specific peptidase 34
chr7_+_141438122	24.296	NM_003143	SSBP1	single-stranded DNA binding protein 1
chr19_+_49838646	24.065		CD37	CD37 molecule
chr2_+_219081898	23.549		ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr2_-_61765367	23.546		XPO1	exportin 1 (CRM1 homolog, yeast)
chr10_-_88281515	23.497	NM_015045	WAPAL	wings apart-like homolog (Drosophila)
chrX_-_15872905	23.471
chr11_+_128563772	23.451	NM_001167681 NM_002017	FLI1	Friend leukemia virus integration 1
chr1_+_111415721	23.414	NM_000560	CD53	CD53 molecule
chr2_+_143886969	23.360		ARHGAP15	Rho GTPase activating protein 15
chr2_-_174828775	23.042	NM_001017371	SP3	Sp3 transcription factor
chr3_-_195163575	23.002	NM_012287	ACAP2	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr6_+_31553955	22.969	NM_205838 NM_205839	LST1	leukocyte specific transcript 1
chr2_-_153573858	22.825	NM_017892	PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr19_+_48828820	22.817		EMP3	epithelial membrane protein 3
chr19_+_35646006	22.808		FXYD5	FXYD domain containing ion transport regulator 5
chr17_-_29641087	22.633		EVI2B	ecotropic viral integration site 2B
chr2_-_136873740	22.599	NM_001008540	CXCR4	chemokine (C-X-C motif) receptor 4
chr17_+_43299277	22.486	NM_005892	FMNL1	formin-like 1
chr14_-_24616429	22.475		PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_-_150552127	22.185	NM_001197320 NM_021960 NM_182763	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)
chr12_+_69004684	22.164		RAP1B	RAP1B, member of RAS oncogene family
chr3_-_121379757	22.012	NM_005335	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr12_+_25205488	22.005		LRMP	lymphoid-restricted membrane protein
chr14_-_23285011	22.001	NM_001126105	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr17_-_56084611	21.937		SRSF1	serine/arginine-rich splicing factor 1
chr17_-_62657997	21.823		SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr1_-_31230594	21.804		LAPTM5	lysosomal protein transmembrane 5
chr12_+_69004614	21.717	NM_001010942 NM_001251917 NM_001251918 NM_001251921 NM_001251922 NM_015646	RAP1B	RAP1B, member of RAS oncogene family
chr1_-_184943673	21.491	NM_052966	FAM129A	family with sequence similarity 129, member A
chr3_+_107241782	21.406	NM_001142568 NM_020235	BBX	bobby sox homolog (Drosophila)
chr14_-_99737554	21.205		BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)
chr19_-_9546154	21.034	NM_006631 NM_198058	ZNF266	zinc finger protein 266
chr2_-_32235722	21.021		MEMO1	mediator of cell motility 1
chr12_+_69004710	20.939		RAP1B	RAP1B, member of RAS oncogene family
chr1_-_151032082	20.923	NM_001038707 NM_020239	CDC42SE1	CDC42 small effector 1
chr1_+_26644380	20.902	NM_001803	CD52	CD52 molecule
chr13_+_31287614	20.857	NM_001204406	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr1_-_151032036	20.791		CDC42SE1	CDC42 small effector 1
chr3_-_125094003	20.770	NM_021964	ZNF148	zinc finger protein 148
chr6_-_33282006	20.700	NM_003190 NM_172208 NM_172209	TAPBP	TAP binding protein (tapasin)
chr4_-_174254730	20.680	NM_001130689	HMGB2	high mobility group box 2
chr6_-_31704281	20.630		CLIC1	chloride intracellular channel 1
chr9_+_131451519	20.606		SET	SET nuclear oncogene
chr7_-_99698278	20.486	NM_182776	MCM7	minichromosome maintenance complex component 7
chr10_-_27149989	20.384	NM_001012750 NM_001012751 NM_001012752 NM_001178116 NM_001178119 NM_001178120 NM_001178121 NM_001178122 NM_001178123 NM_001178124 NM_001178125 NM_005470	ABI1	abl-interactor 1
chr8_-_101733735	20.202		PABPC1	poly(A) binding protein, cytoplasmic 1
chr19_+_49838734	19.994		CD37	CD37 molecule
chr12_+_7055753	19.674		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr6_+_41748488	19.513	NM_013397	PRICKLE4	prickle homolog 4 (Drosophila)
chr14_+_96968768	19.412		PAPOLA	poly(A) polymerase alpha
chr2_-_32235603	19.400	NM_001137602 NM_015955	MEMO1	mediator of cell motility 1
chr6_+_42896859	19.324	NM_006586	CNPY3	canopy 3 homolog (zebrafish)
chrX_-_15872882	19.243		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr14_+_21249209	19.190	NM_005615	RNASE6	ribonuclease, RNase A family, k6
chr3_-_121379701	19.090		HCLS1	hematopoietic cell-specific Lyn substrate 1
chr17_+_45727274	19.058	NM_002265	KPNB1	karyopherin (importin) beta 1
chr3_-_156878481	19.010	NM_020307	CCNL1	cyclin L1
chr19_+_49376488	18.979		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr6_-_79787939	18.923	NM_017934	PHIP	pleckstrin homology domain interacting protein
chr12_-_49960221	18.750	NM_001012300	MCRS1	microspherule protein 1
chr12_-_110888079	18.716		ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa
chr19_+_48828627	18.678	NM_001425	EMP3	epithelial membrane protein 3
chr12_-_108954952	18.651		SART3	squamous cell carcinoma antigen recognized by T cells 3
chr6_-_31704304	18.651		CLIC1	chloride intracellular channel 1
chr2_-_61765394	18.636	NM_003400	XPO1	exportin 1 (CRM1 homolog, yeast)
chr17_+_65822242	18.612		BPTF	bromodomain PHD finger transcription factor
chr6_+_26368405	18.600	NM_001197246	BTN3A2	butyrophilin, subfamily 3, member A2
chr19_-_39108534	18.587	NM_001042600 NM_007181	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr8_+_56792399	18.573		LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr6_-_31324564	18.548		HLA-B HLA-C	major histocompatibility complex, class I, B major histocompatibility complex, class I, C
chr12_-_110888134	18.510		ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa
chr6_-_75994496	18.486		TMEM30A	transmembrane protein 30A
chr19_-_8642309	18.378	NM_012335	MYO1F	myosin IF
chr16_-_89043215	18.334	NM_005187	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr14_-_35344490	18.312		BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr12_-_108954942	18.279		SART3	squamous cell carcinoma antigen recognized by T cells 3
chr14_-_99737821	18.247	NM_022898 NM_138576	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)
chr12_-_53601051	18.245		ITGB7	integrin, beta 7
chr2_+_68592317	18.155	NM_002664	PLEK	pleckstrin
chr14_-_35344526	18.031		BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr1_-_147931877	17.925		FLJ39739	uncharacterized FLJ39739
chr12_-_92539614	17.917	NM_001731	BTG1	B-cell translocation gene 1, anti-proliferative
chr8_+_56792345	17.894	NM_001111097 NM_002350	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_-_224622000	17.856	NM_001115113 NM_025160	WDR26	WD repeat domain 26
chr7_+_74188308	17.840	NM_000265	NCF1 NCF1B	neutrophil cytosolic factor 1 neutrophil cytosolic factor 1B pseudogene
chrX_+_123095555	17.742	NM_001042750 NM_001042751 NM_006603	STAG2	stromal antigen 2
chr12_-_53600999	17.645	NM_000889	ITGB7	integrin, beta 7
chr8_+_126442557	17.622	NM_025195	TRIB1	tribbles homolog 1 (Drosophila)
chr12_-_49319211	17.603	NM_001143782 NM_016594	FKBP11	FK506 binding protein 11, 19 kDa
chr1_+_113161723	17.598		CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1
chr3_+_180630431	17.573		FXR1	fragile X mental retardation, autosomal homolog 1
chr12_+_7060433	17.571	NM_002831 NM_080549	PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr22_-_50964856	17.533	NM_001169109	SCO2	SCO cytochrome oxidase deficient homolog 2 (yeast)
chr1_+_155178489	17.344	NM_002455 NM_198883	MTX1	metaxin 1
chr6_-_75994631	17.299	NM_001143958 NM_018247	TMEM30A	transmembrane protein 30A
chr22_-_37882214	17.290	NM_001166343 NM_002405	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr12_+_54891539	17.202		NCKAP1L	NCK-associated protein 1-like
chr8_+_56792392	17.142		LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chrX_-_15872921	17.060		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr2_-_61765345	17.034		XPO1	exportin 1 (CRM1 homolog, yeast)
chr12_-_31479120	16.980	NM_001135811 NM_021238 NM_001135812	FAM60A	family with sequence similarity 60, member A
chr3_+_38179968	16.944	NM_001172566 NM_001172567 NM_001172568 NM_001172569 NM_002468	MYD88	myeloid differentiation primary response gene (88)
chr11_-_2018885	16.883		H19 RPS12	H19, imprinted maternally expressed transcript (non-protein coding) ribosomal protein S12
chr3_-_16555128	16.844	NM_015150	RFTN1	raftlin, lipid raft linker 1
chr12_+_54891522	16.762		NCKAP1L	NCK-associated protein 1-like
chr20_+_47835964	16.639		DDX27	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chrX_+_47004693	16.629		RBM10	RNA binding motif protein 10
chr12_+_54891491	16.611	NM_005337	NCKAP1L	NCK-associated protein 1-like
chr1_-_150552005	16.518		MCL1	myeloid cell leukemia sequence 1 (BCL2-related)
chr12_-_57505176	16.494	NM_001178078 NM_001178080 NM_001178081 NM_003153	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced
chr1_+_112162397	16.491	NM_001010935 NM_002884	RAP1A	RAP1A, member of RAS oncogene family
chr1_-_155948934	16.481		ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr18_+_56338818	16.445		MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1
chr17_-_34417386	16.428	NM_002983	CCL3	chemokine (C-C motif) ligand 3
chr17_+_37026351	16.400		LASP1	LIM and SH3 protein 1
chr6_-_32157511	16.334	NM_002586	PBX2	pre-B-cell leukemia homeobox 2
chr11_-_3862183	16.236	NM_001665	RHOG	ras homolog gene family, member G (rho G)
chr2_+_219081914	16.150		ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr6_-_32160637	15.974		GPSM3	G-protein signaling modulator 3
chr2_+_143886898	15.884	NM_018460	ARHGAP15	Rho GTPase activating protein 15
chr1_-_183559669	15.839	NM_000433 NM_001190789 NM_001190794	NCF2	neutrophil cytosolic factor 2
chr6_-_75994477	15.803		TMEM30A	transmembrane protein 30A
chr1_-_183560010	15.752	NM_001127651	NCF2	neutrophil cytosolic factor 2
chr12_-_56652118	15.731	NM_173595	ANKRD52	ankyrin repeat domain 52
chr14_-_23284617	15.666		SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_-_120687956	15.651	NM_025157	PXN	paxillin
chr6_+_155054549	15.647		SCAF8	SR-related CTD-associated factor 8
chr19_-_8642337	15.571		MYO1F	myosin IF
chr10_+_28822387	15.542	NM_016628 NM_100486	WAC	WW domain containing adaptor with coiled-coil
chr20_+_43514350	15.541		YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr22_+_37309618	15.492	NM_000395	CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr17_+_1733263	15.458	NM_002945	RPA1	replication protein A1, 70kDa
chr11_-_67120943	15.430	NM_021173	POLD4	polymerase (DNA-directed), delta 4

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.20	8.12e-63	GO:0009987	cellular process
1.47	3.34e-60	GO:0044260	cellular macromolecule metabolic process
1.35	6.60e-55	GO:0044237	cellular metabolic process
1.41	1.39e-54	GO:0043170	macromolecule metabolic process
1.28	2.60e-44	GO:0008152	metabolic process
1.31	2.82e-43	GO:0044238	primary metabolic process
1.52	3.56e-39	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.58	1.69e-37	GO:0090304	nucleic acid metabolic process
1.25	1.59e-35	GO:0050789	regulation of biological process
1.25	2.30e-33	GO:0050794	regulation of cellular process
1.22	8.18e-33	GO:0065007	biological regulation
1.62	3.95e-32	GO:0016070	RNA metabolic process
1.43	5.49e-32	GO:0034641	cellular nitrogen compound metabolic process
1.42	2.55e-31	GO:0006807	nitrogen compound metabolic process
1.56	1.81e-28	GO:0010467	gene expression
1.46	1.79e-27	GO:0044267	cellular protein metabolic process
1.67	1.07e-25	GO:0002376	immune system process
1.32	8.68e-24	GO:0051716	cellular response to stimulus
1.39	3.42e-21	GO:0048518	positive regulation of biological process
1.41	8.14e-21	GO:0048522	positive regulation of cellular process
1.36	1.10e-20	GO:0019538	protein metabolic process
1.41	2.45e-20	GO:0006950	response to stress
1.33	2.85e-20	GO:0071840	cellular component organization or biogenesis
1.33	3.80e-20	GO:0016043	cellular component organization
1.94	6.89e-20	GO:0016071	mRNA metabolic process
1.33	1.02e-19	GO:0060255	regulation of macromolecule metabolic process
1.30	2.65e-19	GO:0019222	regulation of metabolic process
1.49	7.48e-19	GO:0009059	macromolecule biosynthetic process
1.31	1.25e-18	GO:0031323	regulation of cellular metabolic process
1.48	3.16e-18	GO:0034645	cellular macromolecule biosynthetic process
1.39	9.01e-18	GO:0048519	negative regulation of biological process
1.41	3.15e-17	GO:0048523	negative regulation of cellular process
2.16	1.07e-16	GO:0008380	RNA splicing
1.30	1.35e-16	GO:0080090	regulation of primary metabolic process
1.59	9.65e-16	GO:0032268	regulation of cellular protein metabolic process
1.30	1.48e-15	GO:0007165	signal transduction
1.69	3.04e-15	GO:0006955	immune response
1.74	9.49e-15	GO:0006396	RNA processing
1.35	1.47e-14	GO:0044249	cellular biosynthetic process
1.55	1.68e-14	GO:0051246	regulation of protein metabolic process
1.74	1.79e-14	GO:0051726	regulation of cell cycle
1.56	4.26e-14	GO:0042981	regulation of apoptosis
1.56	4.55e-14	GO:0043067	regulation of programmed cell death
1.40	5.58e-14	GO:0006464	protein modification process
1.97	6.56e-14	GO:0044419	interspecies interaction between organisms
1.39	8.75e-14	GO:0043412	macromolecule modification
1.32	9.79e-14	GO:0071841	cellular component organization or biogenesis at cellular level
1.62	1.51e-13	GO:0033554	cellular response to stress
1.32	1.93e-13	GO:0071842	cellular component organization at cellular level
2.29	1.95e-13	GO:0000375	RNA splicing, via transesterification reactions
2.30	2.95e-13	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.30	2.95e-13	GO:0000398	nuclear mRNA splicing, via spliceosome
1.53	5.44e-13	GO:0010941	regulation of cell death
1.18	8.02e-13	GO:0050896	response to stimulus
1.32	1.30e-12	GO:0009058	biosynthetic process
1.61	1.33e-12	GO:0031399	regulation of protein modification process
1.76	1.33e-12	GO:0044265	cellular macromolecule catabolic process
1.70	2.11e-12	GO:0009057	macromolecule catabolic process
1.89	2.83e-12	GO:0006397	mRNA processing
1.54	3.81e-12	GO:0032774	RNA biosynthetic process
1.40	1.16e-11	GO:0006996	organelle organization
1.48	1.30e-11	GO:0031325	positive regulation of cellular metabolic process
1.48	1.58e-11	GO:0010604	positive regulation of macromolecule metabolic process
1.37	1.59e-11	GO:0048583	regulation of response to stimulus
1.24	2.17e-11	GO:0023052	signaling
1.59	2.20e-11	GO:0046907	intracellular transport
1.83	2.57e-11	GO:0016032	viral reproduction
1.62	5.27e-11	GO:0002682	regulation of immune system process
2.07	6.63e-11	GO:0045321	leukocyte activation
1.44	1.16e-10	GO:0051641	cellular localization
1.72	1.21e-10	GO:0006974	response to DNA damage stimulus
1.55	1.46e-10	GO:0043933	macromolecular complex subunit organization
1.72	1.83e-10	GO:0001775	cell activation
1.44	1.95e-10	GO:0009893	positive regulation of metabolic process
1.82	3.10e-09	GO:0010564	regulation of cell cycle process
1.50	4.20e-09	GO:0051704	multi-organism process
1.28	4.97e-09	GO:0010468	regulation of gene expression
1.44	6.96e-09	GO:0051649	establishment of localization in cell
1.27	9.83e-09	GO:0031326	regulation of cellular biosynthetic process
1.61	1.04e-08	GO:0071822	protein complex subunit organization
1.26	1.57e-08	GO:0009889	regulation of biosynthetic process
1.26	2.01e-08	GO:0051171	regulation of nitrogen compound metabolic process
1.37	2.25e-08	GO:0065009	regulation of molecular function
1.27	2.47e-08	GO:0010556	regulation of macromolecule biosynthetic process
1.45	3.07e-08	GO:0007049	cell cycle
1.65	4.06e-08	GO:0007599	hemostasis
1.48	4.41e-08	GO:0006351	transcription, DNA-dependent
1.65	4.62e-08	GO:0007596	blood coagulation
1.65	4.62e-08	GO:0050817	coagulation
1.58	5.97e-08	GO:0051276	chromosome organization
1.45	6.46e-08	GO:0009892	negative regulation of metabolic process
1.54	6.88e-08	GO:0019220	regulation of phosphate metabolic process
1.54	6.88e-08	GO:0051174	regulation of phosphorus metabolic process
1.67	8.55e-08	GO:0050776	regulation of immune response
1.40	1.14e-07	GO:0044248	cellular catabolic process
1.27	1.24e-07	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.43	1.66e-07	GO:0006793	phosphorus metabolic process
1.43	1.66e-07	GO:0006796	phosphate metabolic process
1.58	1.95e-07	GO:0050878	regulation of body fluid levels
2.06	2.24e-07	GO:0002757	immune response-activating signal transduction
1.82	2.60e-07	GO:0006366	transcription from RNA polymerase II promoter
1.46	2.99e-07	GO:0008219	cell death
1.73	3.54e-07	GO:0016568	chromatin modification
1.62	3.82e-07	GO:0034621	cellular macromolecular complex subunit organization
1.56	4.56e-07	GO:0006259	DNA metabolic process
1.36	4.80e-07	GO:0035556	intracellular signal transduction
1.52	5.08e-07	GO:0042325	regulation of phosphorylation
1.45	5.18e-07	GO:0016265	death
1.51	6.84e-07	GO:0065003	macromolecular complex assembly
1.64	7.01e-07	GO:0002684	positive regulation of immune system process
1.65	7.47e-07	GO:0043069	negative regulation of programmed cell death
2.01	8.29e-07	GO:0002764	immune response-regulating signaling pathway
1.98	8.86e-07	GO:0046649	lymphocyte activation
1.69	9.61e-07	GO:0032270	positive regulation of cellular protein metabolic process
2.16	1.38e-06	GO:0019058	viral infectious cycle
1.64	1.42e-06	GO:0043066	negative regulation of apoptosis
1.98	1.43e-06	GO:0022411	cellular component disassembly
1.98	1.43e-06	GO:0071845	cellular component disassembly at cellular level
1.48	1.50e-06	GO:0016192	vesicle-mediated transport
1.43	1.54e-06	GO:0031324	negative regulation of cellular metabolic process
1.66	1.60e-06	GO:0051247	positive regulation of protein metabolic process
1.73	1.68e-06	GO:0070647	protein modification by small protein conjugation or removal
1.34	1.73e-06	GO:0009056	catabolic process
1.43	1.76e-06	GO:0010605	negative regulation of macromolecule metabolic process
1.26	1.94e-06	GO:0051252	regulation of RNA metabolic process
1.61	2.26e-06	GO:0006325	chromatin organization
1.37	2.36e-06	GO:0050790	regulation of catalytic activity
1.23	2.44e-06	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.88	2.58e-06	GO:0071156	regulation of cell cycle arrest
1.59	3.30e-06	GO:0043549	regulation of kinase activity
1.33	3.51e-06	GO:0009966	regulation of signal transduction
2.25	3.69e-06	GO:0051320	S phase
1.51	3.75e-06	GO:0001932	regulation of protein phosphorylation
1.44	4.03e-06	GO:0031328	positive regulation of cellular biosynthetic process
1.35	4.28e-06	GO:0010033	response to organic substance
1.71	5.13e-06	GO:0051603	proteolysis involved in cellular protein catabolic process
2.09	5.55e-06	GO:0000082	G1/S transition of mitotic cell cycle
2.24	5.61e-06	GO:0000084	S phase of mitotic cell cycle
1.60	7.09e-06	GO:0060548	negative regulation of cell death
1.47	7.24e-06	GO:0012501	programmed cell death
1.52	8.40e-06	GO:0042060	wound healing
1.69	8.54e-06	GO:0044257	cellular protein catabolic process
1.43	1.11e-05	GO:0044093	positive regulation of molecular function
2.01	1.13e-05	GO:0022415	viral reproductive process
1.86	1.16e-05	GO:0000075	cell cycle checkpoint
1.55	1.23e-05	GO:0043068	positive regulation of programmed cell death
1.43	1.24e-05	GO:0048584	positive regulation of response to stimulus
1.42	1.29e-05	GO:0009891	positive regulation of biosynthetic process
1.55	1.40e-05	GO:0043065	positive regulation of apoptosis
1.46	1.58e-05	GO:0006915	apoptosis
1.39	1.78e-05	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.35	1.93e-05	GO:0044085	cellular component biogenesis
2.30	1.99e-05	GO:0050851	antigen receptor-mediated signaling pathway
1.74	2.38e-05	GO:0010608	posttranscriptional regulation of gene expression
1.54	2.61e-05	GO:0051338	regulation of transferase activity
1.29	3.03e-05	GO:0023051	regulation of signaling
1.41	3.06e-05	GO:0016310	phosphorylation
1.37	3.17e-05	GO:0022607	cellular component assembly
1.64	3.79e-05	GO:0030163	protein catabolic process
1.40	3.84e-05	GO:0009611	response to wounding
1.67	4.16e-05	GO:0019941	modification-dependent protein catabolic process
1.53	4.49e-05	GO:0010942	positive regulation of cell death
1.24	4.49e-05	GO:0042221	response to chemical stimulus
1.27	4.50e-05	GO:0007166	cell surface receptor linked signaling pathway
1.69	4.57e-05	GO:0006412	translation
1.55	4.95e-05	GO:0045859	regulation of protein kinase activity
1.67	5.10e-05	GO:0051098	regulation of binding
1.38	5.78e-05	GO:0042127	regulation of cell proliferation
1.69	5.88e-05	GO:0051329	interphase of mitotic cell cycle
1.70	6.12e-05	GO:0002520	immune system development
1.66	6.23e-05	GO:0043632	modification-dependent macromolecule catabolic process
1.73	6.72e-05	GO:0007346	regulation of mitotic cell cycle
1.64	6.75e-05	GO:0006281	DNA repair
1.70	6.93e-05	GO:0050778	positive regulation of immune response
1.41	7.21e-05	GO:0022402	cell cycle process
1.68	7.84e-05	GO:0051325	interphase
1.71	8.13e-05	GO:0032446	protein modification by small protein conjugation
1.42	9.17e-05	GO:0051173	positive regulation of nitrogen compound metabolic process
1.51	1.08e-04	GO:0080134	regulation of response to stress
1.66	1.11e-04	GO:0006511	ubiquitin-dependent protein catabolic process
1.79	1.13e-04	GO:0002253	activation of immune response
1.61	1.16e-04	GO:0045087	innate immune response
1.42	1.31e-04	GO:0010557	positive regulation of macromolecule biosynthetic process
1.79	1.43e-04	GO:0051249	regulation of lymphocyte activation
2.16	1.45e-04	GO:0002429	immune response-activating cell surface receptor signaling pathway
1.31	1.49e-04	GO:0033036	macromolecule localization
2.18	1.51e-04	GO:0006414	translational elongation
2.20	1.55e-04	GO:0030098	lymphocyte differentiation
1.23	1.68e-04	GO:0065008	regulation of biological quality
1.56	1.84e-04	GO:0007243	intracellular protein kinase cascade
1.56	1.84e-04	GO:0023014	signal transduction via phosphorylation event
1.40	1.89e-04	GO:0006952	defense response
1.52	1.95e-04	GO:0070271	protein complex biogenesis
1.88	2.16e-04	GO:0051251	positive regulation of lymphocyte activation
1.52	2.22e-04	GO:0006461	protein complex assembly
1.86	2.30e-04	GO:0016569	covalent chromatin modification
1.61	2.52e-04	GO:0006917	induction of apoptosis
1.44	2.87e-04	GO:0071310	cellular response to organic substance
1.90	2.94e-04	GO:0031400	negative regulation of protein modification process
1.34	3.02e-04	GO:0010646	regulation of cell communication
1.60	3.03e-04	GO:0012502	induction of programmed cell death
1.83	3.11e-04	GO:0050867	positive regulation of cell activation
1.67	3.25e-04	GO:0071900	regulation of protein serine/threonine kinase activity
1.65	3.35e-04	GO:0031401	positive regulation of protein modification process
1.40	3.50e-04	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.75	3.85e-04	GO:0002274	myeloid leukocyte activation
1.68	3.86e-04	GO:0048534	hemopoietic or lymphoid organ development
1.49	3.98e-04	GO:0070727	cellular macromolecule localization
1.70	4.74e-04	GO:0050865	regulation of cell activation
1.37	5.14e-04	GO:0015031	protein transport
1.72	5.55e-04	GO:0030097	hemopoiesis
2.08	6.14e-04	GO:0002768	immune response-regulating cell surface receptor signaling pathway
1.84	6.27e-04	GO:0016570	histone modification
1.46	6.34e-04	GO:0000278	mitotic cell cycle
1.71	6.89e-04	GO:0032269	negative regulation of cellular protein metabolic process
1.48	7.91e-04	GO:0034613	cellular protein localization
1.81	8.32e-04	GO:0002696	positive regulation of leukocyte activation
1.61	8.50e-04	GO:0033043	regulation of organelle organization
2.06	8.64e-04	GO:0000077	DNA damage checkpoint
1.22	1.00e-03	GO:0006355	regulation of transcription, DNA-dependent
1.40	1.17e-03	GO:0043085	positive regulation of catalytic activity
2.04	1.21e-03	GO:0032984	macromolecular complex disassembly
2.04	1.21e-03	GO:0034623	cellular macromolecular complex disassembly
1.32	1.22e-03	GO:0008104	protein localization
1.85	1.41e-03	GO:0010498	proteasomal protein catabolic process
1.85	1.41e-03	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
1.69	1.48e-03	GO:0002694	regulation of leukocyte activation
1.96	1.50e-03	GO:0002521	leukocyte differentiation
1.35	1.51e-03	GO:0045184	establishment of protein localization
1.54	1.58e-03	GO:0006886	intracellular protein transport
1.84	1.64e-03	GO:0006417	regulation of translation
1.66	1.64e-03	GO:0016567	protein ubiquitination
1.86	1.75e-03	GO:0050900	leukocyte migration
2.18	1.88e-03	GO:0019080	viral genome expression
2.18	1.88e-03	GO:0019083	viral transcription
1.65	1.89e-03	GO:0051101	regulation of DNA binding
1.38	2.06e-03	GO:0006468	protein phosphorylation
1.80	2.16e-03	GO:0050863	regulation of T cell activation
1.66	2.59e-03	GO:0051248	negative regulation of protein metabolic process
1.39	2.71e-03	GO:0022403	cell cycle phase
1.53	2.80e-03	GO:0010627	regulation of intracellular protein kinase cascade
1.98	2.90e-03	GO:0031570	DNA integrity checkpoint
2.19	2.95e-03	GO:0000216	M/G1 transition of mitotic cell cycle
2.38	2.97e-03	GO:0006368	transcription elongation from RNA polymerase II promoter
2.22	3.02e-03	GO:0050852	T cell receptor signaling pathway
2.00	3.44e-03	GO:0006401	RNA catabolic process
2.00	3.44e-03	GO:0042770	signal transduction in response to DNA damage
1.71	3.68e-03	GO:0006916	anti-apoptosis
1.96	3.94e-03	GO:0042110	T cell activation
1.33	4.46e-03	GO:0070887	cellular response to chemical stimulus
1.16	4.46e-03	GO:0051179	localization
1.77	4.46e-03	GO:0045088	regulation of innate immune response
2.05	4.66e-03	GO:0043241	protein complex disassembly
2.05	4.66e-03	GO:0043624	cellular protein complex disassembly
1.87	5.09e-03	GO:0006310	DNA recombination
1.56	5.09e-03	GO:0031347	regulation of defense response
2.10	5.64e-03	GO:0006415	translational termination
1.44	6.81e-03	GO:0044092	negative regulation of molecular function
1.52	6.88e-03	GO:0034622	cellular macromolecular complex assembly
1.47	8.66e-03	GO:0008283	cell proliferation
1.54	8.67e-03	GO:0045597	positive regulation of cell differentiation
1.38	8.73e-03	GO:0051254	positive regulation of RNA metabolic process
2.48	9.58e-03	GO:0002263	cell activation involved in immune response
2.48	9.58e-03	GO:0002366	leukocyte activation involved in immune response
1.84	9.63e-03	GO:0050870	positive regulation of T cell activation
2.02	9.68e-03	GO:0051340	regulation of ligase activity
1.82	9.96e-03	GO:0031396	regulation of protein ubiquitination
2.18	1.03e-02	GO:0042113	B cell activation
1.46	1.13e-02	GO:0016044	cellular membrane organization
1.99	1.23e-02	GO:0040029	regulation of gene expression, epigenetic
1.95	1.39e-02	GO:0090068	positive regulation of cell cycle process
2.13	1.43e-02	GO:0006354	transcription elongation, DNA-dependent
1.45	1.48e-02	GO:0061024	membrane organization
1.44	1.56e-02	GO:0009628	response to abiotic stimulus
1.88	1.65e-02	GO:0043388	positive regulation of DNA binding
2.23	1.66e-02	GO:0071158	positive regulation of cell cycle arrest
1.85	1.74e-02	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
1.58	1.86e-02	GO:0001817	regulation of cytokine production
2.10	2.05e-02	GO:0000956	nuclear-transcribed mRNA catabolic process
2.55	2.05e-02	GO:0006283	transcription-coupled nucleotide-excision repair
2.01	2.16e-02	GO:0051438	regulation of ubiquitin-protein ligase activity
2.22	2.53e-02	GO:0048524	positive regulation of viral reproduction
1.79	2.64e-02	GO:0051099	positive regulation of binding
1.88	2.68e-02	GO:0007265	Ras protein signal transduction
2.05	2.70e-02	GO:0022618	ribonucleoprotein complex assembly
1.44	2.82e-02	GO:0051094	positive regulation of developmental process
1.66	2.96e-02	GO:0043405	regulation of MAP kinase activity
1.41	2.99e-02	GO:0009967	positive regulation of signal transduction
1.89	3.30e-02	GO:0051028	mRNA transport
1.35	3.48e-02	GO:0009890	negative regulation of biosynthetic process
2.03	3.77e-02	GO:2000045	regulation of G1/S transition of mitotic cell cycle
1.51	3.82e-02	GO:0032535	regulation of cellular component size
1.69	4.22e-02	GO:0051169	nuclear transport
2.06	4.35e-02	GO:0008063	Toll signaling pathway
1.28	4.40e-02	GO:0009605	response to external stimulus
1.37	4.55e-02	GO:0010629	negative regulation of gene expression

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.19	4.09e-64	GO:0044424	intracellular part
1.18	1.33e-58	GO:0005622	intracellular
1.67	7.44e-52	GO:0044428	nuclear part
1.61	2.84e-46	GO:0031974	membrane-enclosed lumen
1.70	5.30e-46	GO:0031981	nuclear lumen
1.24	8.66e-46	GO:0005737	cytoplasm
1.23	2.14e-45	GO:0043227	membrane-bounded organelle
1.22	3.98e-45	GO:0043231	intracellular membrane-bounded organelle
1.60	5.38e-45	GO:0043233	organelle lumen
1.60	1.14e-43	GO:0070013	intracellular organelle lumen
1.19	1.70e-42	GO:0043229	intracellular organelle
1.19	1.98e-42	GO:0043226	organelle
1.33	4.19e-42	GO:0005634	nucleus
1.33	5.94e-42	GO:0044446	intracellular organelle part
1.32	5.64e-41	GO:0044422	organelle part
1.42	9.35e-37	GO:0032991	macromolecular complex
1.75	1.24e-36	GO:0005654	nucleoplasm
1.56	1.86e-34	GO:0005829	cytosol
1.25	3.97e-28	GO:0044444	cytoplasmic part
1.36	3.49e-22	GO:0043234	protein complex
1.87	1.09e-17	GO:0030529	ribonucleoprotein complex
1.69	5.27e-16	GO:0044451	nucleoplasm part
1.06	7.52e-16	GO:0044464	cell part
1.06	8.28e-16	GO:0005623	cell
1.31	1.27e-14	GO:0043228	non-membrane-bounded organelle
1.31	1.27e-14	GO:0043232	intracellular non-membrane-bounded organelle
1.65	1.33e-10	GO:0005694	chromosome
1.98	3.48e-09	GO:0016604	nuclear body
1.62	1.31e-08	GO:0005730	nucleolus
1.62	7.11e-08	GO:0044427	chromosomal part
2.09	1.34e-06	GO:0005681	spliceosomal complex
1.77	4.44e-05	GO:0000228	nuclear chromosome
1.41	5.32e-05	GO:0031967	organelle envelope
2.55	6.25e-05	GO:0016605	PML body
1.85	6.58e-05	GO:0044454	nuclear chromosome part
1.72	7.44e-05	GO:0000785	chromatin
1.22	8.97e-05	GO:0031090	organelle membrane
1.39	1.38e-04	GO:0031975	envelope
1.68	2.14e-04	GO:0005635	nuclear envelope
1.85	3.10e-04	GO:0044445	cytosolic part
2.17	6.55e-04	GO:0071013	catalytic step 2 spliceosome
1.90	1.30e-03	GO:0016607	nuclear speck
1.94	1.92e-03	GO:0030055	cell-substrate junction
3.43	3.15e-03	GO:0030530	heterogeneous nuclear ribonucleoprotein complex
1.99	4.48e-03	GO:0016585	chromatin remodeling complex
1.43	5.03e-03	GO:0005768	endosome
1.67	5.38e-03	GO:0005840	ribosome
1.22	6.02e-03	GO:0012505	endomembrane system
1.98	6.66e-03	GO:0042470	melanosome
1.98	6.66e-03	GO:0048770	pigment granule
2.06	9.92e-03	GO:0016591	DNA-directed RNA polymerase II, holoenzyme
2.06	9.92e-03	GO:0022626	cytosolic ribosome
1.87	1.07e-02	GO:0005924	cell-substrate adherens junction
4.75	1.24e-02	GO:0005885	Arp2/3 protein complex
1.97	1.60e-02	GO:0000790	nuclear chromatin
1.87	1.74e-02	GO:0005925	focal adhesion
1.72	1.81e-02	GO:0031965	nuclear membrane
1.78	1.89e-02	GO:0044455	mitochondrial membrane part
2.52	2.90e-02	GO:0042645	mitochondrial nucleoid
2.03	3.35e-02	GO:0034399	nuclear periphery
1.51	3.67e-02	GO:0044440	endosomal part
2.62	3.98e-02	GO:0008305	integrin complex
2.15	4.63e-02	GO:0034708	methyltransferase complex
2.15	4.63e-02	GO:0035097	histone methyltransferase complex
2.44	4.79e-02	GO:0009295	nucleoid
1.50	4.85e-02	GO:0010008	endosome membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.40	6.11e-101	GO:0005515	protein binding
1.16	2.20e-52	GO:0005488	binding
1.70	3.86e-19	GO:0003723	RNA binding
1.31	9.15e-12	GO:0000166	nucleotide binding
1.57	4.19e-11	GO:0019899	enzyme binding
1.78	3.93e-10	GO:0000988	protein binding transcription factor activity
1.78	3.93e-10	GO:0000989	transcription factor binding transcription factor activity
1.78	7.15e-10	GO:0003712	transcription cofactor activity
1.21	4.59e-08	GO:0003676	nucleic acid binding
1.28	1.13e-06	GO:0035639	purine ribonucleoside triphosphate binding
2.07	1.35e-06	GO:0003714	transcription corepressor activity
1.30	3.10e-06	GO:0005524	ATP binding
1.26	4.39e-06	GO:0032553	ribonucleotide binding
1.26	4.39e-06	GO:0032555	purine ribonucleotide binding
1.75	4.61e-06	GO:0032403	protein complex binding
1.26	4.94e-06	GO:0017076	purine nucleotide binding
1.29	7.24e-06	GO:0032559	adenyl ribonucleotide binding
1.29	1.01e-05	GO:0030554	adenyl nucleotide binding
2.97	2.05e-05	GO:0003823	antigen binding
1.41	5.25e-05	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.38	1.17e-04	GO:0016301	kinase activity
1.35	1.64e-04	GO:0016772	transferase activity, transferring phosphorus-containing groups
1.12	3.45e-04	GO:0003824	catalytic activity
1.77	3.75e-04	GO:0043566	structure-specific DNA binding
1.42	4.61e-04	GO:0004672	protein kinase activity
1.69	8.26e-04	GO:0003713	transcription coactivator activity
1.66	9.16e-04	GO:0019900	kinase binding
1.37	2.35e-03	GO:0046983	protein dimerization activity
2.11	2.47e-03	GO:0008135	translation factor activity, nucleic acid binding
2.34	3.00e-03	GO:0003697	single-stranded DNA binding
2.26	3.03e-03	GO:0008094	DNA-dependent ATPase activity
1.45	3.66e-03	GO:0019904	protein domain specific binding
2.11	3.73e-03	GO:0031625	ubiquitin protein ligase binding
2.15	4.12e-03	GO:0047485	protein N-terminus binding
4.75	4.73e-03	GO:0019864	IgG binding
1.55	4.99e-03	GO:0008134	transcription factor binding
1.21	6.37e-03	GO:0016740	transferase activity
1.33	8.39e-03	GO:0042802	identical protein binding
2.38	1.05e-02	GO:0003743	translation initiation factor activity
1.71	1.25e-02	GO:0004721	phosphoprotein phosphatase activity
1.77	1.32e-02	GO:0004386	helicase activity
1.27	1.32e-02	GO:0030528	transcription regulator activity
2.50	1.45e-02	GO:0003678	DNA helicase activity
1.56	1.56e-02	GO:0016791	phosphatase activity
2.06	1.80e-02	GO:0042393	histone binding
1.71	2.56e-02	GO:0003735	structural constituent of ribosome
1.61	2.56e-02	GO:0019901	protein kinase binding
1.61	4.30e-02	GO:0003682	chromatin binding
1.98	4.72e-02	GO:0003729	mRNA binding