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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: SPIB.p2

Z-value: 3.276

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_-_15114495	107.151	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chrX_+_48542159	60.204	NM_000377	WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr19_+_49838673	42.039	NM_001040031 NM_001774	CD37	CD37 molecule
chr19_+_49838700	41.913		CD37	CD37 molecule
chr19_-_41859253	41.857		TGFB1	transforming growth factor, beta 1
chr19_+_49838646	40.151		CD37	CD37 molecule
chr6_+_31553955	37.698	NM_205838 NM_205839	LST1	leukocyte specific transcript 1
chr6_-_32160289	35.723		GPSM3	G-protein signaling modulator 3
chr3_-_121379757	34.369	NM_005335	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr16_+_30194925	33.401		CORO1A	coronin, actin binding protein, 1A
chr19_+_49838734	32.469		CD37	CD37 molecule
chr1_-_183560010	32.250	NM_001127651	NCF2	neutrophil cytosolic factor 2
chr3_-_121379701	31.390		HCLS1	hematopoietic cell-specific Lyn substrate 1
chr11_-_58343308	31.120	NM_004811	LPXN	leupaxin
chr1_-_183559669	29.665	NM_000433 NM_001190789 NM_001190794	NCF2	neutrophil cytosolic factor 2
chr19_-_41859519	29.264		TGFB1	transforming growth factor, beta 1
chr2_-_175499275	28.722	NM_003387	WIPF1	WAS/WASL interacting protein family, member 1
chr5_+_169064274	28.235		DOCK2	dedicator of cytokinesis 2
chr12_+_54891539	28.069		NCKAP1L	NCK-associated protein 1-like
chr19_-_41859332	27.978		TGFB1	transforming growth factor, beta 1
chr14_+_88471467	27.296	NM_003608	GPR65	G protein-coupled receptor 65
chr17_+_34431219	26.940	NM_002984	CCL4	chemokine (C-C motif) ligand 4
chr1_-_153518265	26.662	NM_002961 NM_019554	S100A4	S100 calcium binding protein A4
chr12_+_54891522	26.503		NCKAP1L	NCK-associated protein 1-like
chr12_+_6898605	26.441	NM_000616 NM_001195014 NM_001195015 NM_001195016 NM_001195017	CD4	CD4 molecule
chr5_-_169724782	26.148		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_+_7060538	26.035		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr12_+_54891491	25.861	NM_005337	NCKAP1L	NCK-associated protein 1-like
chr1_-_25256364	25.755		RUNX3	runt-related transcription factor 3
chr19_-_41859830	25.518	NM_000660	TGFB1	transforming growth factor, beta 1
chr12_+_25205180	25.391	NM_001204126 NM_001204127 NM_006152	LRMP	lymphoid-restricted membrane protein
chr12_+_7060517	25.385		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060543	25.375		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060531	25.137		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr19_-_36233311	24.840	NM_024660	IGFLR1	IGF-like family receptor 1
chr12_+_7060554	24.459		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060433	24.338	NM_002831 NM_080549	PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr17_+_34640030	24.038	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr5_-_169724817	23.822	NM_005565	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr2_+_65454828	23.727	NM_001005386 NM_005722	ACTR2	ARP2 actin-related protein 2 homolog (yeast)
chr5_-_169724734	23.642		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_+_35645614	22.610	NM_014164	FXYD5	FXYD domain containing ion transport regulator 5
chr10_+_70847857	22.480		SRGN	serglycin
chr8_-_101734290	20.965		PABPC1	poly(A) binding protein, cytoplasmic 1
chr1_-_183559463	20.691		NCF2	neutrophil cytosolic factor 2
chr14_-_35344852	20.626	NM_013448 NM_182648	BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr6_+_31554475	20.242	NM_205837	LST1	leukocyte specific transcript 1
chr10_+_70847817	20.141	NM_002727	SRGN	serglycin
chr12_+_6898705	19.485		CD4	CD4 molecule
chr14_+_100531764	19.473		EVL	Enah/Vasp-like
chr8_-_101734162	19.407		PABPC1	poly(A) binding protein, cytoplasmic 1
chr5_-_149466126	19.290		CSF1R	colony stimulating factor 1 receptor
chr8_-_101734313	18.775	NM_002568	PABPC1	poly(A) binding protein, cytoplasmic 1
chr17_+_40439564	18.534	NM_003152	STAT5A	signal transducer and activator of transcription 5A
chr17_+_34538464	18.337	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chrX_+_109246338	18.095	NM_032227	TMEM164	transmembrane protein 164
chr3_+_152017193	18.020	NM_207293 NM_207294 NM_207295 NM_207296 NM_207297	MBNL1	muscleblind-like (Drosophila)
chr8_-_134115309	17.941	NM_001045556 NM_001045557	SLA	Src-like-adaptor
chr7_+_139528951	17.869	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr5_-_169724614	17.778		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_+_25205488	17.482		LRMP	lymphoid-restricted membrane protein
chr14_+_100531745	17.200	NM_016337	EVL	Enah/Vasp-like
chr17_-_29648631	16.912	NM_001003927 NM_014210	EVI2A	ecotropic viral integration site 2A
chr14_+_64971504	16.630		ZBTB1	zinc finger and BTB domain containing 1
chr17_-_29641094	16.395	NM_006495	EVI2B	ecotropic viral integration site 2B
chr15_+_77287738	16.332		PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr1_+_209929378	16.235	NM_025228	TRAF3IP3	TRAF3 interacting protein 3
chr5_-_149466173	16.234		CSF1R	colony stimulating factor 1 receptor
chr12_-_89746238	16.127		DUSP6	dual specificity phosphatase 6
chr12_-_9760481	16.072	NM_002258	KLRB1	killer cell lectin-like receptor subfamily B, member 1
chrX_-_53449548	16.038		SMC1A	structural maintenance of chromosomes 1A
chr22_+_23222897	15.973		CYAT1	immunoglobulin lambda light chain-like
chrX_+_119737743	15.958	NM_014060	MCTS1	malignant T cell amplified sequence 1
chrX_+_48542193	15.877		WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr5_+_115898218	15.843
chr18_-_18691765	15.842	NM_005406	ROCK1	Rho-associated, coiled-coil containing protein kinase 1
chr17_+_42422665	15.802		GRN	granulin
chr2_-_96811138	15.785	NM_004418	DUSP2	dual specificity phosphatase 2
chr17_-_62084282	15.662	NM_000873	ICAM2	intercellular adhesion molecule 2
chr11_-_33890931	15.658		LMO2	LIM domain only 2 (rhombotin-like 1)
chr5_+_118691692	15.638		TNFAIP8	tumor necrosis factor, alpha-induced protein 8
chr4_+_103422822	15.599		NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr8_-_101733735	15.598		PABPC1	poly(A) binding protein, cytoplasmic 1
chr2_+_233925035	15.567	NM_001017915 NM_005541	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chr15_+_77287688	15.490		PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr6_-_24936177	15.267		FAM65B	family with sequence similarity 65, member B
chr15_+_75074714	15.154		CSK	c-src tyrosine kinase
chr17_-_29641087	15.070		EVI2B	ecotropic viral integration site 2B
chr1_-_153919140	15.009	NM_014856	DENND4B	DENN/MADD domain containing 4B
chr6_-_32634287	14.984	NM_001243961 NM_002123	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1
chr19_+_39109831	14.979		EIF3K	eukaryotic translation initiation factor 3, subunit K
chr12_-_89745997	14.858		DUSP6	dual specificity phosphatase 6
chr16_+_30194730	14.846	NM_001193333 NM_007074	CORO1A	coronin, actin binding protein, 1A
chr10_-_27149892	14.826		ABI1	abl-interactor 1
chrX_-_135863104	14.744		ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_+_31582978	14.677	NM_004847 NM_001623	AIF1	allograft inflammatory factor 1
chr1_-_25291474	14.630	NM_001031680	RUNX3	runt-related transcription factor 3
chr22_-_37640287	14.606	NM_002872	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr8_+_98703361	14.566		MTDH	metadherin
chr19_-_51875790	14.511	NM_005601	NKG7	natural killer cell group 7 sequence
chr13_-_49110117	14.482		RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chrX_-_70331297	14.468	NM_000206	IL2RG	interleukin 2 receptor, gamma
chr2_-_55496314	14.465	NM_001005369	MTIF2	mitochondrial translational initiation factor 2
chrX_-_135863033	14.427		ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr3_-_150263899	14.330		SERP1	stress-associated endoplasmic reticulum protein 1
chr19_-_39826676	14.325	NM_004877	GMFG	glia maturation factor, gamma
chrX_+_119738542	14.252	NM_001137554	MCTS1	malignant T cell amplified sequence 1
chrX_+_123234462	14.252		STAG2	stromal antigen 2
chr15_+_75074417	14.214	NM_001127190 NM_004383	CSK	c-src tyrosine kinase
chr12_-_89746244	14.147	NM_001946 NM_022652	DUSP6	dual specificity phosphatase 6
chr19_+_39109807	14.129		EIF3K	eukaryotic translation initiation factor 3, subunit K
chr11_-_33891361	14.107	NM_001142316	LMO2	LIM domain only 2 (rhombotin-like 1)
chr15_+_77287428	14.049	NM_003978	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr19_-_39826625	13.949		GMFG	glia maturation factor, gamma
chrX_-_20285141	13.913		RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3
chrX_-_129244652	13.867	NM_001127197	ELF4	E74-like factor 4 (ets domain transcription factor)
chr1_-_59248287	13.759		JUN	jun proto-oncogene
chr3_+_158519925	13.679		MFSD1	major facilitator superfamily domain containing 1
chr16_+_28505920	13.572	NM_018690	APOBR	apolipoprotein B receptor
chr1_-_27226928	13.410		GPATCH3	G patch domain containing 3
chr4_-_185395616	13.358	NM_002199	IRF2	interferon regulatory factor 2
chr5_+_169064238	13.287	NM_004946	DOCK2	dedicator of cytokinesis 2
chr5_-_150466696	13.262	NM_001252391 NM_001252392	TNIP1	TNFAIP3 interacting protein 1
chr11_+_75110552	13.194	NM_001005	RPS3	ribosomal protein S3
chr8_+_22437983	13.144	NM_176871 NM_198042	PDLIM2	PDZ and LIM domain 2 (mystique)
chr11_+_121461070	13.010		SORL1	sortilin-related receptor, L(DLR class) A repeats containing
chr5_-_149466094	12.850		CSF1R	colony stimulating factor 1 receptor
chr11_-_67205151	12.847	NM_005608	PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein
chr11_-_33891258	12.823		LMO2	LIM domain only 2 (rhombotin-like 1)
chr19_+_1067293	12.778		HMHA1	histocompatibility (minor) HA-1
chr11_-_16996559	12.777		RPL36A	ribosomal protein L36a
chr7_+_143079354	12.716		ZYX	zyxin
chr2_+_219081864	12.694	NM_152862	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr1_-_207095198	12.650	NM_001193338 NM_001142473 NM_005449	FAIM3	Fas apoptotic inhibitory molecule 3
chr21_-_46340821	12.402		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr21_-_46340776	12.386		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_-_150467220	12.368	NM_001252390	TNIP1	TNFAIP3 interacting protein 1
chr19_+_1067536	12.357		HMHA1	histocompatibility (minor) HA-1
chr4_-_103748966	12.356	NM_003340 NM_181886 NM_181888 NM_181889	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chr19_+_1067114	12.347	NM_012292	HMHA1	histocompatibility (minor) HA-1
chrX_+_37639246	12.332	NM_000397	CYBB	cytochrome b-245, beta polypeptide
chr11_+_308106	12.233	NM_006435	IFITM2	interferon induced transmembrane protein 2 (1-8D)
chr2_+_68592317	12.066	NM_002664	PLEK	pleckstrin
chr21_-_46340874	12.019	NM_000211	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_-_55496347	11.968	NM_002453	MTIF2	mitochondrial translational initiation factor 2
chr2_+_233925104	11.895		INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chr6_-_32160637	11.880		GPSM3	G-protein signaling modulator 3
chrX_+_119737984	11.854		MCTS1	malignant T cell amplified sequence 1
chr10_+_104535887	11.742	NM_017787	C10orf26	chromosome 10 open reading frame 26
chr1_-_20987881	11.660		DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr8_-_101964248	11.624		YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr21_-_46348633	11.573	NM_001127491	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chrX_+_24073060	11.520	NM_001415	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr13_-_46756295	11.508		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_26644458	11.498		CD52	CD52 molecule
chr3_-_129035069	11.483	NM_006026	H1FX	H1 histone family, member X
chr4_+_40198526	11.475	NM_004310	RHOH	ras homolog gene family, member H
chrX_-_47489703	11.395	NM_002621	CFP	complement factor properdin
chr4_+_103422730	11.394		NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_-_10450262	11.384	NM_002162	ICAM3	intercellular adhesion molecule 3
chr5_+_96211643	11.351	NM_001130140 NM_022350	ERAP2	endoplasmic reticulum aminopeptidase 2
chr6_+_26368405	11.347	NM_001197246	BTN3A2	butyrophilin, subfamily 3, member A2
chrX_+_24073071	11.344		EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chrX_-_73834460	11.337	NM_016120 NM_183353	RLIM	ring finger protein, LIM domain interacting
chr11_-_64645925	11.296		EHD1	EH-domain containing 1
chr4_-_103748254	11.287	NM_181892	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chr4_-_25864430	11.279	NM_015187	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)
chrX_-_47489243	11.268	NM_001145252	CFP	complement factor properdin
chr8_-_146017774	11.267		RPL8	ribosomal protein L8
chr17_-_7297826	11.267		PLSCR3	phospholipid scramblase 3
chr2_+_219082119	11.244	NM_005731	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr14_-_69354900	11.173		ACTN1	actinin, alpha 1
chr10_+_70715883	11.161	NM_004728	DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr17_+_7462064	11.145		TNFSF13	tumor necrosis factor (ligand) superfamily, member 13
chr17_+_76164624	11.121	NM_004710	SYNGR2	synaptogyrin 2
chr11_+_65408387	11.119
chr1_-_25256767	11.104	NM_004350	RUNX3	runt-related transcription factor 3
chr13_-_46756326	11.083	NM_002298	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_106013951	11.055	NM_001191003	GSTO1	glutathione S-transferase omega 1
chr12_-_9102193	11.001		M6PR	mannose-6-phosphate receptor (cation dependent)
chr2_+_233415300	10.865	NM_004846	EIF4E2	eukaryotic translation initiation factor 4E family member 2
chr17_-_42275425	10.742	NM_001098833 NM_020218	ATXN7L3	ataxin 7-like 3
chr17_+_25958245	10.712		LGALS9	lectin, galactoside-binding, soluble, 9
chr10_-_27149989	10.690	NM_001012750 NM_001012751 NM_001012752 NM_001178116 NM_001178119 NM_001178120 NM_001178121 NM_001178122 NM_001178123 NM_001178124 NM_001178125 NM_005470	ABI1	abl-interactor 1
chr6_-_42714547	10.658		TBCC	tubulin folding cofactor C
chr5_+_75699003	10.539	NM_006633	IQGAP2	IQ motif containing GTPase activating protein 2
chr1_-_31230594	10.517		LAPTM5	lysosomal protein transmembrane 5
chr13_+_31287614	10.468	NM_001204406	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr9_+_100745644	10.467		ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr13_+_31309690	10.428		ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr15_-_65281771	10.398	NM_001127889	SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr1_-_150241409	10.397	NM_001077628 NM_001243771 NM_001243772 NM_016022	APH1A	anterior pharynx defective 1 homolog A (C. elegans)
chr17_+_25958257	10.350		LGALS9	lectin, galactoside-binding, soluble, 9
chr7_+_99971132	10.157		PILRA	paired immunoglobin-like type 2 receptor alpha
chr22_-_37640187	10.118		RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr12_-_9102262	10.117	NM_001207024 NM_002355	M6PR	mannose-6-phosphate receptor (cation dependent)
chr6_-_31324975	10.114	NM_005514	HLA-B	major histocompatibility complex, class I, B
chr9_+_100745456	10.108	NM_006401	ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr6_-_31550065	10.092	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr22_+_37257004	10.043	NM_000631 NM_013416	NCF4	neutrophil cytosolic factor 4, 40kDa

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.21	2.72e-51	GO:0009987	cellular process
1.53	6.60e-51	GO:0044260	cellular macromolecule metabolic process
1.39	8.55e-47	GO:0044237	cellular metabolic process
1.44	1.92e-42	GO:0043170	macromolecule metabolic process
2.04	9.88e-41	GO:0002376	immune system process
1.81	3.27e-39	GO:0010467	gene expression
1.31	5.29e-37	GO:0008152	metabolic process
1.81	1.61e-36	GO:0016070	RNA metabolic process
1.33	3.35e-35	GO:0044238	primary metabolic process
1.59	3.05e-34	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.67	4.22e-33	GO:0090304	nucleic acid metabolic process
1.49	9.75e-28	GO:0034641	cellular nitrogen compound metabolic process
2.13	2.48e-27	GO:0006955	immune response
1.56	4.67e-27	GO:0044267	cellular protein metabolic process
1.47	7.98e-27	GO:0006807	nitrogen compound metabolic process
1.69	4.60e-26	GO:0009059	macromolecule biosynthetic process
1.69	1.36e-25	GO:0034645	cellular macromolecule biosynthetic process
2.69	3.11e-23	GO:0006412	translation
1.23	1.26e-20	GO:0050789	regulation of biological process
1.50	2.64e-20	GO:0044249	cellular biosynthetic process
2.01	4.74e-20	GO:0002682	regulation of immune system process
1.23	9.93e-20	GO:0050794	regulation of cellular process
2.27	1.07e-19	GO:0050776	regulation of immune response
2.04	1.37e-19	GO:0006396	RNA processing
1.21	2.65e-19	GO:0065007	biological regulation
1.47	6.50e-19	GO:0009058	biosynthetic process
3.78	1.03e-18	GO:0006414	translational elongation
1.41	2.40e-18	GO:0019538	protein metabolic process
1.80	4.61e-18	GO:0032774	RNA biosynthetic process
3.30	7.12e-18	GO:0019058	viral infectious cycle
1.37	1.14e-17	GO:0071840	cellular component organization or biogenesis
3.91	4.42e-17	GO:0019080	viral genome expression
3.91	4.42e-17	GO:0019083	viral transcription
2.18	8.14e-17	GO:0002684	positive regulation of immune system process
1.45	8.76e-17	GO:0006950	response to stress
3.04	1.03e-16	GO:0022415	viral reproductive process
2.05	3.11e-16	GO:0016071	mRNA metabolic process
2.89	3.91e-16	GO:0002757	immune response-activating signal transduction
3.78	3.92e-16	GO:0006415	translational termination
2.40	9.69e-16	GO:0008380	RNA splicing
1.36	1.27e-15	GO:0016043	cellular component organization
1.35	1.37e-15	GO:0007165	signal transduction
2.27	1.62e-15	GO:0044419	interspecies interaction between organisms
2.82	2.06e-15	GO:0002764	immune response-regulating signaling pathway
3.40	2.19e-15	GO:0032984	macromolecular complex disassembly
3.40	2.19e-15	GO:0034623	cellular macromolecular complex disassembly
1.80	4.51e-15	GO:0006952	defense response
1.40	7.00e-15	GO:0071841	cellular component organization or biogenesis at cellular level
2.74	1.50e-14	GO:0022411	cellular component disassembly
2.74	1.50e-14	GO:0071845	cellular component disassembly at cellular level
3.49	1.92e-14	GO:0043241	protein complex disassembly
3.49	1.92e-14	GO:0043624	cellular protein complex disassembly
2.18	2.31e-14	GO:0006397	mRNA processing
1.30	3.55e-14	GO:0051716	cellular response to stimulus
1.74	6.09e-14	GO:0051704	multi-organism process
2.65	6.69e-13	GO:0050867	positive regulation of cell activation
1.38	8.07e-13	GO:0071842	cellular component organization at cellular level
1.98	8.30e-13	GO:0034621	cellular macromolecular complex subunit organization
2.59	1.10e-12	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.59	1.10e-12	GO:0000398	nuclear mRNA splicing, via spliceosome
1.37	1.15e-12	GO:0048518	positive regulation of biological process
3.35	1.47e-12	GO:0050851	antigen receptor-mediated signaling pathway
2.56	1.64e-12	GO:0000375	RNA splicing, via transesterification reactions
2.69	2.64e-12	GO:0051251	positive regulation of lymphocyte activation
2.62	3.43e-12	GO:0002696	positive regulation of leukocyte activation
1.39	7.53e-12	GO:0048519	negative regulation of biological process
2.25	8.36e-12	GO:0050778	positive regulation of immune response
1.93	1.65e-11	GO:0001775	cell activation
1.38	1.74e-11	GO:0048522	positive regulation of cellular process
3.15	1.78e-11	GO:0002429	immune response-activating cell surface receptor signaling pathway
1.20	2.12e-11	GO:0050896	response to stimulus
1.44	2.17e-11	GO:0048583	regulation of response to stimulus
2.41	2.24e-11	GO:0002253	activation of immune response
2.02	2.60e-11	GO:0016032	viral reproduction
2.07	5.02e-11	GO:0045087	innate immune response
1.68	5.93e-11	GO:0043933	macromolecular complex subunit organization
1.28	8.65e-11	GO:0023052	signaling
2.32	9.05e-11	GO:0045321	leukocyte activation
3.03	1.22e-10	GO:0002768	immune response-regulating cell surface receptor signaling pathway
2.39	1.37e-10	GO:0051249	regulation of lymphocyte activation
2.76	1.54e-10	GO:0050870	positive regulation of T cell activation
2.91	1.55e-10	GO:0031018	endocrine pancreas development
1.39	1.96e-10	GO:0048523	negative regulation of cellular process
1.80	2.88e-10	GO:0071822	protein complex subunit organization
1.28	3.15e-10	GO:0031323	regulation of cellular metabolic process
1.68	4.81e-10	GO:0046907	intracellular transport
2.51	1.08e-09	GO:0050863	regulation of T cell activation
1.29	1.51e-09	GO:0060255	regulation of macromolecule metabolic process
2.25	1.53e-09	GO:0002694	regulation of leukocyte activation
1.26	1.55e-09	GO:0019222	regulation of metabolic process
2.22	1.79e-09	GO:0050865	regulation of cell activation
2.64	2.77e-09	GO:0031016	pancreas development
1.56	3.78e-09	GO:0042981	regulation of apoptosis
1.55	5.19e-09	GO:0043067	regulation of programmed cell death
2.79	5.83e-09	GO:0042110	T cell activation
4.22	6.39e-09	GO:0006413	translational initiation
1.54	8.63e-09	GO:0010941	regulation of cell death
1.27	1.16e-08	GO:0080090	regulation of primary metabolic process
1.39	1.73e-08	GO:0006464	protein modification process
3.46	1.95e-08	GO:0031294	lymphocyte costimulation
3.46	1.95e-08	GO:0031295	T cell costimulation
3.21	2.06e-08	GO:0050852	T cell receptor signaling pathway
2.32	2.94e-08	GO:0046649	lymphocyte activation
1.39	3.38e-08	GO:0007166	cell surface receptor linked signaling pathway
1.37	4.06e-08	GO:0043412	macromolecule modification
1.57	1.05e-07	GO:0006351	transcription, DNA-dependent
1.46	1.14e-07	GO:0051641	cellular localization
1.54	4.91e-07	GO:0009611	response to wounding
1.75	5.17e-07	GO:0007596	blood coagulation
1.75	5.17e-07	GO:0050817	coagulation
1.29	7.92e-07	GO:0010468	regulation of gene expression
1.74	8.15e-07	GO:0007599	hemostasis
2.37	8.81e-07	GO:0050900	leukocyte migration
2.99	8.81e-07	GO:0008063	Toll signaling pathway
1.46	1.06e-06	GO:0010604	positive regulation of macromolecule metabolic process
1.56	1.35e-06	GO:0048584	positive regulation of response to stimulus
2.19	1.36e-06	GO:0022613	ribonucleoprotein complex biogenesis
1.65	1.38e-06	GO:0009057	macromolecule catabolic process
1.47	1.58e-06	GO:0051649	establishment of localization in cell
2.24	1.70e-06	GO:0035270	endocrine system development
1.71	1.77e-06	GO:0070727	cellular macromolecule localization
1.43	1.84e-06	GO:0009893	positive regulation of metabolic process
1.70	2.07e-06	GO:0044265	cellular macromolecule catabolic process
1.45	2.30e-06	GO:0031325	positive regulation of cellular metabolic process
1.70	2.34e-06	GO:0034613	cellular protein localization
1.49	2.34e-06	GO:0009892	negative regulation of metabolic process
1.37	2.43e-06	GO:0006996	organelle organization
3.10	3.16e-06	GO:0002756	MyD88-independent toll-like receptor signaling pathway
1.41	3.73e-06	GO:0035556	intracellular signal transduction
2.91	4.13e-06	GO:0034142	toll-like receptor 4 signaling pathway
1.52	4.84e-06	GO:0015031	protein transport
1.96	4.93e-06	GO:0010608	posttranscriptional regulation of gene expression
2.11	5.33e-06	GO:0071843	cellular component biogenesis at cellular level
1.50	5.59e-06	GO:0010605	negative regulation of macromolecule metabolic process
1.44	5.87e-06	GO:0044085	cellular component biogenesis
1.50	6.60e-06	GO:0031324	negative regulation of cellular metabolic process
1.51	6.96e-06	GO:0045184	establishment of protein localization
2.10	9.16e-06	GO:0006605	protein targeting
1.78	1.08e-05	GO:0006886	intracellular protein transport
1.64	1.20e-05	GO:0050878	regulation of body fluid levels
1.28	1.24e-05	GO:0010556	regulation of macromolecule biosynthetic process
1.43	1.67e-05	GO:0044248	cellular catabolic process
3.04	1.95e-05	GO:0060333	interferon-gamma-mediated signaling pathway
2.92	1.96e-05	GO:0034130	toll-like receptor 1 signaling pathway
2.92	1.96e-05	GO:0034134	toll-like receptor 2 signaling pathway
2.61	2.83e-05	GO:0002758	innate immune response-activating signal transduction
2.99	3.08e-05	GO:0034138	toll-like receptor 3 signaling pathway
1.86	3.24e-05	GO:0034097	response to cytokine stimulus
1.39	3.44e-05	GO:0033036	macromolecule localization
1.68	3.62e-05	GO:0006325	chromatin organization
1.78	3.65e-05	GO:0016568	chromatin modification
1.43	3.84e-05	GO:0008104	protein localization
1.57	4.45e-05	GO:0071310	cellular response to organic substance
2.36	4.48e-05	GO:0045089	positive regulation of innate immune response
1.26	4.56e-05	GO:0031326	regulation of cellular biosynthetic process
1.25	5.51e-05	GO:0009889	regulation of biosynthetic process
2.56	5.63e-05	GO:0002218	activation of innate immune response
2.87	5.82e-05	GO:0071346	cellular response to interferon-gamma
1.59	6.75e-05	GO:0042060	wound healing
2.11	6.98e-05	GO:0045088	regulation of innate immune response
1.44	8.19e-05	GO:0032268	regulation of cellular protein metabolic process
1.54	8.76e-05	GO:0031327	negative regulation of cellular biosynthetic process
2.00	8.86e-05	GO:0033365	protein localization to organelle
1.57	8.95e-05	GO:0051276	chromosome organization
1.64	9.12e-05	GO:0009607	response to biotic stimulus
1.84	9.38e-05	GO:0006366	transcription from RNA polymerase II promoter
2.76	1.01e-04	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
1.26	1.03e-04	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.42	1.09e-04	GO:0051246	regulation of protein metabolic process
2.14	1.11e-04	GO:0006417	regulation of translation
1.48	1.24e-04	GO:0031328	positive regulation of cellular biosynthetic process
2.60	1.34e-04	GO:0002224	toll-like receptor signaling pathway
1.79	1.36e-04	GO:0031347	regulation of defense response
2.56	1.41e-04	GO:0002221	pattern recognition receptor signaling pathway
1.35	1.42e-04	GO:0009056	catabolic process
2.31	1.43e-04	GO:0042254	ribosome biogenesis
1.47	1.55e-04	GO:0009891	positive regulation of biosynthetic process
2.21	1.55e-04	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade
2.11	1.78e-04	GO:0031349	positive regulation of defense response
2.27	1.81e-04	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
1.52	2.02e-04	GO:0009890	negative regulation of biosynthetic process
2.32	2.65e-04	GO:0017038	protein import
1.53	3.12e-04	GO:0010558	negative regulation of macromolecule biosynthetic process
1.43	3.22e-04	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.26	3.35e-04	GO:0051252	regulation of RNA metabolic process
2.51	3.67e-04	GO:0006364	rRNA processing
1.74	3.73e-04	GO:0018193	peptidyl-amino acid modification
1.94	4.01e-04	GO:0071345	cellular response to cytokine stimulus
1.49	4.11e-04	GO:0010557	positive regulation of macromolecule biosynthetic process
1.36	4.89e-04	GO:0010033	response to organic substance
1.66	5.41e-04	GO:0051707	response to other organism
1.98	6.87e-04	GO:0019221	cytokine-mediated signaling pathway
3.05	6.89e-04	GO:0051403	stress-activated MAPK cascade
1.54	6.93e-04	GO:0010629	negative regulation of gene expression
1.86	9.18e-04	GO:0030097	hemopoiesis
1.80	1.02e-03	GO:0001817	regulation of cytokine production
2.52	1.23e-03	GO:0034341	response to interferon-gamma
1.99	1.56e-03	GO:0006913	nucleocytoplasmic transport
1.79	1.60e-03	GO:0048534	hemopoietic or lymphoid organ development
2.18	1.67e-03	GO:0045333	cellular respiration
1.51	1.70e-03	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
2.38	1.72e-03	GO:0016072	rRNA metabolic process
1.25	1.73e-03	GO:0042221	response to chemical stimulus
1.98	1.91e-03	GO:0016569	covalent chromatin modification
1.51	1.95e-03	GO:0051172	negative regulation of nitrogen compound metabolic process
1.22	2.14e-03	GO:0051171	regulation of nitrogen compound metabolic process
1.73	2.17e-03	GO:0048610	cellular process involved in reproduction
1.96	2.34e-03	GO:0051169	nuclear transport
1.97	2.60e-03	GO:0016570	histone modification
2.15	2.73e-03	GO:0002521	leukocyte differentiation
1.54	2.78e-03	GO:0051253	negative regulation of RNA metabolic process
1.48	3.46e-03	GO:0051254	positive regulation of RNA metabolic process
1.55	3.50e-03	GO:0080134	regulation of response to stress
1.41	3.67e-03	GO:0016265	death
1.73	3.74e-03	GO:0002520	immune system development
1.41	4.15e-03	GO:0008219	cell death
1.49	4.80e-03	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.00	4.84e-03	GO:0009615	response to virus
1.46	5.13e-03	GO:0065003	macromolecular complex assembly
1.53	5.14e-03	GO:0045892	negative regulation of transcription, DNA-dependent
2.17	5.47e-03	GO:0007265	Ras protein signal transduction
2.77	5.85e-03	GO:0006968	cellular defense response
2.45	5.85e-03	GO:0006839	mitochondrial transport
1.21	6.41e-03	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.09	6.42e-03	GO:0045582	positive regulation of T cell differentiation
1.44	6.87e-03	GO:0006915	apoptosis
1.41	7.11e-03	GO:0033554	cellular response to stress
2.95	8.18e-03	GO:0045621	positive regulation of lymphocyte differentiation
1.73	8.38e-03	GO:0034660	ncRNA metabolic process
4.47	8.80e-03	GO:0042274	ribosomal small subunit biogenesis
1.36	8.87e-03	GO:0006793	phosphorus metabolic process
1.36	8.87e-03	GO:0006796	phosphate metabolic process
2.26	9.48e-03	GO:0030098	lymphocyte differentiation
1.18	9.87e-03	GO:0051179	localization
1.43	1.03e-02	GO:0012501	programmed cell death
1.38	1.11e-02	GO:0070887	cellular response to chemical stimulus
1.58	1.15e-02	GO:0007243	intracellular protein kinase cascade
1.58	1.15e-02	GO:0023014	signal transduction via phosphorylation event
2.26	1.30e-02	GO:0022904	respiratory electron transport chain
1.59	1.38e-02	GO:0006091	generation of precursor metabolites and energy
1.35	1.41e-02	GO:0022607	cellular component assembly
1.86	1.52e-02	GO:0034470	ncRNA processing
1.64	1.54e-02	GO:0051603	proteolysis involved in cellular protein catabolic process
1.39	1.55e-02	GO:0016310	phosphorylation
1.44	1.65e-02	GO:0010628	positive regulation of gene expression
1.46	1.84e-02	GO:0051726	regulation of cell cycle
1.46	1.91e-02	GO:0045893	positive regulation of transcription, DNA-dependent
1.41	1.98e-02	GO:0016192	vesicle-mediated transport
1.63	2.00e-02	GO:0070647	protein modification by small protein conjugation or removal
1.50	2.13e-02	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.60	2.15e-02	GO:0034622	cellular macromolecular complex assembly
1.40	2.16e-02	GO:0051173	positive regulation of nitrogen compound metabolic process
1.58	2.28e-02	GO:0010627	regulation of intracellular protein kinase cascade
1.41	2.34e-02	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.63	2.61e-02	GO:0043632	modification-dependent macromolecule catabolic process
2.52	2.64e-02	GO:0030217	T cell differentiation
1.61	3.30e-02	GO:0044257	cellular protein catabolic process
2.38	3.64e-02	GO:0006606	protein import into nucleus
2.38	3.64e-02	GO:0071216	cellular response to biotic stimulus
2.48	3.64e-02	GO:0034340	response to type I interferon
1.49	3.74e-02	GO:0043065	positive regulation of apoptosis
1.62	3.85e-02	GO:0019941	modification-dependent protein catabolic process
1.48	3.87e-02	GO:0010942	positive regulation of cell death
1.68	3.97e-02	GO:0015980	energy derivation by oxidation of organic compounds
1.46	4.81e-02	GO:0006928	cellular component movement
1.22	4.92e-02	GO:0006355	regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.20	3.73e-51	GO:0044424	intracellular part
1.19	1.37e-49	GO:0005622	intracellular
1.26	8.53e-37	GO:0005737	cytoplasm
1.21	3.39e-35	GO:0043226	organelle
1.24	3.55e-35	GO:0043227	membrane-bounded organelle
1.21	4.85e-35	GO:0043229	intracellular organelle
1.23	1.53e-34	GO:0043231	intracellular membrane-bounded organelle
1.35	1.85e-34	GO:0044446	intracellular organelle part
1.35	4.30e-34	GO:0044422	organelle part
1.47	2.78e-32	GO:0032991	macromolecular complex
1.32	4.31e-31	GO:0044444	cytoplasmic part
2.43	5.99e-31	GO:0030529	ribonucleoprotein complex
1.59	3.82e-30	GO:0031974	membrane-enclosed lumen
1.62	4.81e-30	GO:0044428	nuclear part
1.62	1.46e-28	GO:0005829	cytosol
1.58	5.91e-28	GO:0043233	organelle lumen
1.58	2.39e-27	GO:0070013	intracellular organelle lumen
1.65	8.14e-27	GO:0031981	nuclear lumen
1.72	9.71e-23	GO:0005654	nucleoplasm
1.28	5.42e-22	GO:0005634	nucleus
1.06	1.99e-16	GO:0044464	cell part
1.06	2.15e-16	GO:0005623	cell
2.68	1.94e-14	GO:0005840	ribosome
1.33	9.73e-13	GO:0043234	protein complex
3.60	1.21e-12	GO:0022626	cytosolic ribosome
2.72	9.56e-11	GO:0005681	spliceosomal complex
2.52	9.77e-10	GO:0044445	cytosolic part
1.31	1.80e-09	GO:0043228	non-membrane-bounded organelle
1.31	1.80e-09	GO:0043232	intracellular non-membrane-bounded organelle
1.65	2.56e-09	GO:0044451	nucleoplasm part
2.65	8.55e-09	GO:0044455	mitochondrial membrane part
1.62	1.23e-08	GO:0031975	envelope
2.17	1.47e-08	GO:0016604	nuclear body
1.62	1.87e-08	GO:0031967	organelle envelope
1.33	7.28e-08	GO:0031090	organelle membrane
3.86	6.17e-07	GO:0022625	cytosolic large ribosomal subunit
1.84	8.95e-07	GO:0019866	organelle inner membrane
2.80	2.15e-06	GO:0071013	catalytic step 2 spliceosome
1.93	3.69e-06	GO:0044440	endosomal part
1.65	4.72e-06	GO:0005730	nucleolus
1.83	5.66e-06	GO:0005743	mitochondrial inner membrane
1.92	6.04e-06	GO:0010008	endosome membrane
2.33	1.62e-05	GO:0016607	nuclear speck
2.88	4.19e-05	GO:0015934	large ribosomal subunit
1.62	4.54e-05	GO:0005740	mitochondrial envelope
1.64	5.31e-05	GO:0031966	mitochondrial membrane
1.49	1.19e-04	GO:0044429	mitochondrial part
1.60	1.64e-04	GO:0005768	endosome
2.77	1.82e-04	GO:0005746	mitochondrial respiratory chain
3.44	2.32e-04	GO:0022627	cytosolic small ribosomal subunit
2.66	2.95e-04	GO:0070469	respiratory chain
3.96	4.76e-04	GO:0005689	U12-type spliceosomal complex
2.09	5.57e-04	GO:0043235	receptor complex
4.33	7.37e-04	GO:0030530	heterogeneous nuclear ribonucleoprotein complex
5.00	7.67e-04	GO:0005852	eukaryotic translation initiation factor 3 complex
2.44	7.49e-03	GO:0031902	late endosome membrane
1.45	7.56e-03	GO:0005694	chromosome
2.57	9.65e-03	GO:0015935	small ribosomal subunit
1.70	1.01e-02	GO:0000785	chromatin
2.83	1.40e-02	GO:0005747	mitochondrial respiratory chain complex I
2.83	1.40e-02	GO:0030964	NADH dehydrogenase complex
2.83	1.40e-02	GO:0045271	respiratory chain complex I
1.88	1.98e-02	GO:0009897	external side of plasma membrane
5.05	3.13e-02	GO:0016281	eukaryotic translation initiation factor 4F complex
1.26	3.51e-02	GO:0005739	mitochondrion
5.57	4.59e-02	GO:0005885	Arp2/3 protein complex
4.33	4.92e-02	GO:0042101	T cell receptor complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.38	4.77e-62	GO:0005515	protein binding
1.16	4.53e-38	GO:0005488	binding
2.05	2.62e-28	GO:0003723	RNA binding
2.87	6.32e-14	GO:0003735	structural constituent of ribosome
1.31	8.01e-13	GO:0003676	nucleic acid binding
1.33	1.24e-08	GO:0000166	nucleotide binding
3.66	8.06e-08	GO:0003743	translation initiation factor activity
2.97	9.52e-08	GO:0008135	translation factor activity, nucleic acid binding
1.80	9.77e-07	GO:0000988	protein binding transcription factor activity
1.80	9.77e-07	GO:0000989	transcription factor binding transcription factor activity
1.79	1.80e-06	GO:0003712	transcription cofactor activity
3.41	5.28e-05	GO:0003823	antigen binding
1.64	6.23e-05	GO:0019904	protein domain specific binding
3.33	1.83e-04	GO:0004715	non-membrane spanning protein tyrosine kinase activity
1.27	6.50e-04	GO:0035639	purine ribonucleoside triphosphate binding
1.44	7.02e-04	GO:0019899	enzyme binding
1.25	2.12e-03	GO:0017076	purine nucleotide binding
1.25	2.34e-03	GO:0032553	ribonucleotide binding
1.25	2.34e-03	GO:0032555	purine ribonucleotide binding
1.68	2.70e-03	GO:0008134	transcription factor binding
1.28	3.15e-03	GO:0005524	ATP binding
2.36	5.13e-03	GO:0003729	mRNA binding
1.27	6.49e-03	GO:0030554	adenyl nucleotide binding
1.26	7.97e-03	GO:0032559	adenyl ribonucleotide binding
1.74	1.10e-02	GO:0003713	transcription coactivator activity
6.50	1.31e-02	GO:0001085	RNA polymerase II transcription factor binding
5.69	1.40e-02	GO:0019864	IgG binding
2.25	1.55e-02	GO:0016651	oxidoreductase activity, acting on NADH or NADPH
2.10	1.92e-02	GO:0051427	hormone receptor binding
4.06	2.39e-02	GO:0019865	immunoglobulin binding
2.17	2.43e-02	GO:0035257	nuclear hormone receptor binding
2.22	2.76e-02	GO:0031625	ubiquitin protein ligase binding
2.72	2.77e-02	GO:0016655	oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
2.01	3.08e-02	GO:0017124	SH3 domain binding
1.32	3.70e-02	GO:0016772	transferase activity, transferring phosphorus-containing groups
2.81	4.76e-02	GO:0003954	NADH dehydrogenase activity
2.81	4.76e-02	GO:0008137	NADH dehydrogenase (ubiquinone) activity
2.81	4.76e-02	GO:0050136	NADH dehydrogenase (quinone) activity