Motif ID: TFAP4.p2

Z-value: 1.961


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_4323000,
chr16_-_4322695
-0.153.0e-02Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_23066828 19.557 NM_012072
CD93
CD93 molecule
chr6_+_37137882 16.830 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr1_+_207495086 13.717 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr8_-_48650683 13.421 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_207495070 12.955 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_+_207495009 12.235 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_+_207494816 11.805 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr10_-_3827205 11.110 KLF6
Kruppel-like factor 6
chr3_+_122785855 10.099 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr22_+_23229959 9.945 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr11_-_320925 9.888 IFITM3
interferon induced transmembrane protein 3
chrX_-_106960028 9.582 TSC22D3
TSC22 domain family, member 3
chr10_-_126849010 9.273 CTBP2
C-terminal binding protein 2
chr12_-_92539614 9.166 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr12_-_54813010 9.113 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_+_209848659 9.021 NM_015714
G0S2
G0/G1switch 2
chr1_+_182992694 8.930


chr1_+_55464605 8.892 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr5_-_140013034 8.814 NM_000591
CD14
CD14 molecule
chr1_-_22263676 8.522 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr11_+_67810446 8.490 NM_006053
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr1_+_22963097 8.474 NM_015991
C1QA
complement component 1, q subcomponent, A chain
chr1_+_192778168 8.469 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr14_-_52535737 7.763 NID2
nidogen 2 (osteonidogen)
chr12_-_54812936 7.676 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr16_+_2802708 7.425 SRRM2
serine/arginine repetitive matrix 2
chr3_-_133969563 7.378 NM_001005861
NM_002958
RYK

RYK receptor-like tyrosine kinase

chr7_+_17338182 7.372 NM_001621
AHR
aryl hydrocarbon receptor
chr6_-_134495944 6.915 SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_159175048 6.870 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr16_+_2802683 6.852 SRRM2
serine/arginine repetitive matrix 2
chr12_-_54813002 6.787 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_-_59249687 6.609 NM_002228
JUN
jun proto-oncogene
chr17_-_76921205 6.511 TIMP2
TIMP metallopeptidase inhibitor 2
chr10_-_61469322 6.479 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr17_-_76921076 6.431 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_134496006 6.431 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr19_+_11649578 6.419 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr12_-_8043743 6.286 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr6_+_129204285 6.246 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr10_-_126849066 6.213 NM_001329
CTBP2
C-terminal binding protein 2
chr15_-_75660944 6.207 MAN2C1
mannosidase, alpha, class 2C, member 1
chr9_+_124030413 6.185 GSN
gelsolin
chr14_-_23284617 6.138 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_57044980 6.076 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_-_110959441 6.044 NM_001845
COL4A1
collagen, type IV, alpha 1
chr16_-_11680756 6.039 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr14_-_107170400 5.930 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr15_+_74218962 5.892 LOXL1
lysyl oxidase-like 1
chrX_-_106959597 5.675 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr12_-_56122840 5.616 NM_001040034
NM_001780
CD63

CD63 molecule

chr17_+_41003184 5.591 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr14_-_92414004 5.579 NM_006329
FBLN5
fibulin 5
chr22_-_50964573 5.539 NM_001169110
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr19_+_18682613 5.526 NM_001033930
NM_003333
UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr1_-_6662681 5.515 KLHL21
kelch-like 21 (Drosophila)
chr14_+_21538339 5.495 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr19_+_18284631 5.486 IFI30
interferon, gamma-inducible protein 30
chr9_+_124030455 5.469 GSN
gelsolin
chr6_+_138725458 5.418 HEBP2
heme binding protein 2
chr12_+_64237381 5.394


chr2_-_161349874 5.385 RBMS1
RNA binding motif, single stranded interacting protein 1
chr2_-_197036262 5.361 STK17B
serine/threonine kinase 17b
chr1_+_182992329 5.356 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr22_+_22735134 5.310 CYAT1
immunoglobulin lambda light chain-like
chr13_+_96329392 5.309 NM_006260
DNAJC3
DnaJ (Hsp40) homolog, subfamily C, member 3
chr7_-_45960738 5.295 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr1_-_89591685 5.293 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr3_-_185542807 5.286 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr5_-_140012730 5.266 CD14
CD14 molecule
chr14_-_23284565 5.236 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr6_+_32006092 5.194 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr15_-_75660905 5.174 NM_006715
MAN2C1
mannosidase, alpha, class 2C, member 1
chr7_-_150497398 5.172 NM_001101311
NM_001101312
NM_001101314
TMEM176B


transmembrane protein 176B


chr6_+_31973358 5.157 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr1_+_209848994 5.144 G0S2
G0/G1switch 2
chr14_-_106774311 5.127 IGHA1
immunoglobulin heavy constant alpha 1
chr9_-_35689799 5.115 TPM2
tropomyosin 2 (beta)
chr2_-_161350304 5.100 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr19_-_6720585 5.072 NM_000064
C3
complement component 3
chr7_-_139876718 5.045 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr13_+_100153771 5.038 TM9SF2
transmembrane 9 superfamily member 2
chr14_-_74960003 4.960 NPC2
Niemann-Pick disease, type C2
chr14_-_74960035 4.933 NM_006432
NPC2
Niemann-Pick disease, type C2
chr10_-_103347882 4.930 POLL
polymerase (DNA directed), lambda
chr17_-_76921453 4.881 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_56122800 4.853 CD63
CD63 molecule
chr13_-_79177682 4.841 NM_006237
POU4F1
POU class 4 homeobox 1
chr16_+_222845 4.835 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr14_-_106092256 4.828 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr20_+_35807695 4.811 RPN2
ribophorin II
chr6_+_89791510 4.788 PNRC1
proline-rich nuclear receptor coactivator 1
chr20_+_35807430 4.762 NM_001135771
NM_002951
RPN2

ribophorin II

chr14_-_92413738 4.749 FBLN5
fibulin 5
chr16_+_70502824 4.737 FUK
fucokinase
chr6_-_132272311 4.713 NM_001901
CTGF
connective tissue growth factor
chr20_+_35807747 4.700 RPN2
ribophorin II
chr20_+_35807522 4.690 RPN2
ribophorin II
chr13_-_114567040 4.675 NM_000820
GAS6
growth arrest-specific 6
chr14_-_74959976 4.666 NPC2
Niemann-Pick disease, type C2
chr14_-_52535711 4.649 NID2
nidogen 2 (osteonidogen)
chr1_-_57045129 4.642 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_-_39425297 4.631 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr10_-_105212149 4.626 NM_015916
CALHM2
calcium homeostasis modulator 2
chr21_-_28217272 4.613 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr14_-_106725620 4.600 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr17_+_41006094 4.598 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr16_-_31106049 4.575 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr22_+_22786283 4.573


chr3_-_185542744 4.560 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr15_+_74218786 4.549 NM_005576
LOXL1
lysyl oxidase-like 1
chr17_+_55055467 4.513 NM_021626
SCPEP1
serine carboxypeptidase 1
chr16_-_15835382 4.512 MYH11
myosin, heavy chain 11, smooth muscle
chr17_-_66453561 4.508 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr15_+_74218811 4.497 LOXL1
lysyl oxidase-like 1
chr8_+_97506020 4.488 SDC2
syndecan 2
chr3_+_5021141 4.488 BHLHE40
basic helix-loop-helix family, member e40
chr13_-_114566951 4.430 GAS6
growth arrest-specific 6
chr2_+_17935124 4.407 NM_182625
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr6_-_144385647 4.403 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr11_+_117049838 4.371 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr21_-_28217692 4.369 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr19_-_54746599 4.338 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr11_+_67806454 4.336 NM_006019
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr14_+_101193313 4.325 DLK1
delta-like 1 homolog (Drosophila)
chr3_-_50378238 4.315 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chr1_-_178062734 4.302 LOC100302401
uncharacterized LOC100302401
chrX_-_38079980 4.292 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr1_+_12227050 4.287 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr10_-_103347978 4.279 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr10_-_118429469 4.275 NM_144661
C10orf82
chromosome 10 open reading frame 82
chr11_+_118401873 4.258 TMEM25
transmembrane protein 25
chr17_-_8055684 4.255 NM_002616
PER1
period homolog 1 (Drosophila)
chr22_+_45898690 4.233 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr14_-_52535945 4.222 NM_007361
NID2
nidogen 2 (osteonidogen)
chr9_+_90341030 4.210 CTSL1
cathepsin L1
chr1_+_180123906 4.195 NM_001004128
NM_002826
QSOX1

quiescin Q6 sulfhydryl oxidase 1

chr6_-_144329342 4.188 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chr15_-_48470453 4.177 NM_016132
MYEF2
myelin expression factor 2
chr9_+_90340973 4.168 NM_001912
NM_145918
CTSL1

cathepsin L1

chr14_-_107078578 4.160


chr16_+_29831714 4.149 NM_005115
NM_017458
MVP

major vault protein

chr9_+_90341022 4.145 CTSL1
cathepsin L1
chr7_+_100199881 4.142 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr13_-_114567011 4.138 GAS6
growth arrest-specific 6
chr1_+_180124031 4.138 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr1_+_180124023 4.127 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr13_+_110959592 4.123 NM_001846
COL4A2
collagen, type IV, alpha 2
chr14_+_101193275 4.116 DLK1
delta-like 1 homolog (Drosophila)
chr14_-_94856926 4.102 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr19_-_11689765 4.087 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr16_-_31106125 4.074 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr20_+_19870209 4.071 NM_018993
RIN2
Ras and Rab interactor 2
chr1_-_120612301 4.062 NM_001200001
NM_024408
NOTCH2

notch 2

chr8_+_90770201 4.018 RIPK2
receptor-interacting serine-threonine kinase 2
chr1_+_145209067 4.007 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr8_+_97505895 4.006 SDC2
syndecan 2
chr14_-_106641585 3.991 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_35689902 3.978 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr14_-_106110894 3.958 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr15_+_74218794 3.949 LOXL1
lysyl oxidase-like 1
chr11_+_67806517 3.909 TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr11_-_67120943 3.896 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr14_-_100070442 3.875 NM_001144995
CCDC85C
coiled-coil domain containing 85C
chr7_+_102553343 3.874 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr8_+_144640476 3.870 NM_024736
GSDMD
gasdermin D
chr2_-_209119751 3.861 NM_005896
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr2_+_10183630 3.851 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr16_-_88923233 3.850 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr9_+_124030370 3.839 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr16_-_46865039 3.829 NM_001001436
C16orf87
chromosome 16 open reading frame 87
chr1_-_113249677 3.822 NM_001042679
RHOC
ras homolog gene family, member C
chr11_+_842821 3.814 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr14_+_101193190 3.812 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr18_+_21594349 3.811 NM_001135993
NM_001243425
TTC39C

tetratricopeptide repeat domain 39C

chr22_-_50964856 3.798 NM_001169109
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr9_+_90341123 3.791 CTSL1
cathepsin L1
chr1_-_57045214 3.791 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_+_96329409 3.788 DNAJC3
DnaJ (Hsp40) homolog, subfamily C, member 3
chr2_-_220436010 3.783 OBSL1
obscurin-like 1
chr14_-_23285011 3.779 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr19_+_18284578 3.778 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr1_-_115053677 3.757 TRIM33
tripartite motif containing 33
chr1_+_180124013 3.753 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr4_-_2263808 3.732 MXD4
MAX dimerization protein 4
chr6_+_72596648 3.726 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_113250022 3.723 NM_001042678
NM_175744
RHOC

ras homolog gene family, member C

chr16_-_31106093 3.710 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr13_+_96329398 3.691 DNAJC3
DnaJ (Hsp40) homolog, subfamily C, member 3
chr3_+_122296432 3.662 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr11_+_113930430 3.657 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr8_+_56792399 3.646 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr19_+_39899749 3.643


chr11_-_615649 3.633 NM_004031
IRF7
interferon regulatory factor 7
chr14_-_107013474 3.633 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr15_+_74466887 3.625 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr3_+_148709252 3.616 GYG1
glycogenin 1
chr1_-_120612019 3.615 NOTCH2
notch 2
chr8_-_28243589 3.611 ZNF395
zinc finger protein 395
chr2_-_111230651 3.605 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 8.25e-18 GO:0009987 cellular process
1.19 4.07e-12 GO:0065007 biological regulation
1.36 4.29e-12 GO:0007165 signal transduction
1.33 5.69e-12 GO:0023052 signaling
1.20 1.03e-11 GO:0050789 regulation of biological process
1.30 1.23e-10 GO:0051716 cellular response to stimulus
1.31 1.97e-10 GO:0032502 developmental process
1.33 4.87e-09 GO:0048856 anatomical structure development
1.19 9.73e-09 GO:0050794 regulation of cellular process
1.44 1.82e-08 GO:0048513 organ development
1.49 5.92e-08 GO:0009653 anatomical structure morphogenesis
1.43 1.06e-07 GO:0007166 cell surface receptor linked signaling pathway
1.29 1.76e-07 GO:0007275 multicellular organismal development
1.19 3.26e-07 GO:0050896 response to stimulus
1.31 1.98e-06 GO:0048731 system development
1.68 7.91e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.47 1.50e-05 GO:0002376 immune system process
1.69 2.24e-05 GO:0009887 organ morphogenesis
1.78 2.89e-05 GO:0072358 cardiovascular system development
1.78 2.89e-05 GO:0072359 circulatory system development
1.33 2.96e-05 GO:0048523 negative regulation of cellular process
1.31 3.84e-05 GO:0048519 negative regulation of biological process
1.32 5.02e-05 GO:0042221 response to chemical stimulus
1.26 2.36e-04 GO:0019538 protein metabolic process
1.30 5.17e-04 GO:0065008 regulation of biological quality
1.93 8.04e-04 GO:0001568 blood vessel development
1.32 1.09e-03 GO:0006464 protein modification process
1.89 1.10e-03 GO:0001944 vasculature development
1.17 1.15e-03 GO:0032501 multicellular organismal process
1.58 1.30e-03 GO:0030030 cell projection organization
1.52 1.77e-03 GO:0006955 immune response
1.29 1.86e-03 GO:0048869 cellular developmental process
1.31 2.31e-03 GO:0048583 regulation of response to stimulus
1.22 2.86e-03 GO:0016043 cellular component organization
1.25 3.14e-03 GO:0048518 positive regulation of biological process
1.29 3.43e-03 GO:0030154 cell differentiation
1.17 3.76e-03 GO:0043170 macromolecule metabolic process
2.88 4.31e-03 GO:0007179 transforming growth factor beta receptor signaling pathway
1.29 6.05e-03 GO:0043412 macromolecule modification
1.45 7.32e-03 GO:0009888 tissue development
1.86 7.60e-03 GO:0030334 regulation of cell migration
1.89 9.67e-03 GO:0006897 endocytosis
1.89 9.67e-03 GO:0010324 membrane invagination
1.13 1.00e-02 GO:0044238 primary metabolic process
1.42 1.03e-02 GO:0032879 regulation of localization
1.53 1.06e-02 GO:0032989 cellular component morphogenesis
1.80 1.13e-02 GO:0040012 regulation of locomotion
1.84 1.15e-02 GO:2000145 regulation of cell motility
1.79 1.28e-02 GO:0051270 regulation of cellular component movement
2.33 1.35e-02 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
1.35 1.40e-02 GO:0051239 regulation of multicellular organismal process
1.30 2.02e-02 GO:0023051 regulation of signaling
1.12 2.11e-02 GO:0008152 metabolic process
1.52 2.32e-02 GO:0000902 cell morphogenesis
1.32 2.56e-02 GO:0009966 regulation of signal transduction
1.34 2.68e-02 GO:0010033 response to organic substance
1.52 2.83e-02 GO:0042060 wound healing
1.46 3.44e-02 GO:0006468 protein phosphorylation
1.23 3.66e-02 GO:0006950 response to stress
1.37 3.76e-02 GO:0010646 regulation of cell communication
1.40 3.89e-02 GO:0050793 regulation of developmental process
1.19 3.95e-02 GO:0051179 localization
1.45 3.95e-02 GO:0016192 vesicle-mediated transport
1.86 4.82e-02 GO:0048514 blood vessel morphogenesis
2.83 4.86e-02 GO:0045667 regulation of osteoblast differentiation
2.83 4.86e-02 GO:0048593 camera-type eye morphogenesis
1.19 4.90e-02 GO:0071840 cellular component organization or biogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 7.53e-10 GO:0044459 plasma membrane part
2.12 2.62e-07 GO:0000323 lytic vacuole
2.12 2.62e-07 GO:0005764 lysosome
1.47 5.06e-07 GO:0031226 intrinsic to plasma membrane
1.46 1.90e-06 GO:0005887 integral to plasma membrane
1.95 2.89e-06 GO:0005773 vacuole
1.12 3.40e-05 GO:0005737 cytoplasm
2.42 1.74e-04 GO:0005765 lysosomal membrane
1.40 9.86e-04 GO:0044421 extracellular region part
2.12 1.26e-03 GO:0005774 vacuolar membrane
1.68 1.33e-03 GO:0031012 extracellular matrix
1.18 1.47e-03 GO:0005886 plasma membrane
2.02 2.09e-03 GO:0016324 apical plasma membrane
2.01 3.12e-03 GO:0070161 anchoring junction
1.13 3.40e-03 GO:0044444 cytoplasmic part
1.17 3.52e-03 GO:0071944 cell periphery
2.02 4.26e-03 GO:0044437 vacuolar part
1.07 4.91e-03 GO:0044424 intracellular part
2.01 8.10e-03 GO:0005912 adherens junction
1.35 8.47e-03 GO:0000267 cell fraction
1.68 8.97e-03 GO:0005578 proteinaceous extracellular matrix
1.79 9.22e-03 GO:0016323 basolateral plasma membrane
1.80 1.81e-02 GO:0045177 apical part of cell
1.23 1.88e-02 GO:0005829 cytosol
1.39 2.79e-02 GO:0005615 extracellular space
1.33 3.05e-02 GO:0005783 endoplasmic reticulum
1.06 3.44e-02 GO:0005622 intracellular
2.13 3.67e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 3.33e-11 GO:0005515 protein binding
1.10 1.17e-09 GO:0005488 binding
3.55 4.28e-04 GO:0003823 antigen binding
1.45 7.45e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.17 9.31e-03 GO:0046872 metal ion binding
2.98 1.57e-02 GO:0046332 SMAD binding
2.02 1.77e-02 GO:0003714 transcription corepressor activity
1.16 2.14e-02 GO:0043169 cation binding
1.47 2.14e-02 GO:0004672 protein kinase activity
1.16 2.24e-02 GO:0043167 ion binding
1.40 2.57e-02 GO:0016301 kinase activity
5.53 3.94e-02 GO:0004576 oligosaccharyl transferase activity
2.14 4.14e-02 GO:0019838 growth factor binding