Motif ID: UAAGACU

Z-value: 0.791


Mature miRNA associated with seed UAAGACU:

NamemiRBase Accession
hsa-miR-499-5p MIMAT0002870



Activity profile for motif UAAGACU.

activity profile for motif UAAGACU


Sorted Z-values histogram for motif UAAGACU

Sorted Z-values for motif UAAGACU



Network of associatons between targets according to the STRING database.



First level regulatory network of UAAGACU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_86564632 13.987 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr2_-_86565205 13.368 NM_001164730
REEP1
receptor accessory protein 1
chr5_-_79286793 10.668 NM_001010891
NM_001167741
MTX3

metaxin 3

chr8_-_82359620 9.703 NM_002677
PMP2
peripheral myelin protein 2
chr13_-_44453825 9.145 NM_144974
CCDC122
coiled-coil domain containing 122
chr15_-_48470453 8.864 NM_016132
MYEF2
myelin expression factor 2
chr2_+_66662516 7.847 NM_002398
MEIS1
Meis homeobox 1
chr3_-_18480203 7.467 NM_001131010
SATB1
SATB homeobox 1
chr7_+_86781869 7.259 NM_021145
DMTF1
cyclin D binding myb-like transcription factor 1
chr3_-_18466759 7.232 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr7_-_17980102 7.158 NM_015132
SNX13
sorting nexin 13
chr12_-_42538432 7.059 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr7_+_86781644 6.679 NM_001142326
NM_001142327
DMTF1

cyclin D binding myb-like transcription factor 1

chr19_+_32836500 6.609 NM_001136156
NM_014910
ZNF507

zinc finger protein 507

chr8_+_58906968 6.604 NM_147189
FAM110B
family with sequence similarity 110, member B
chr6_+_72922513 6.512 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr7_+_138916230 6.437 NM_173569
UBN2
ubinuclein 2
chr5_+_161274196 6.251 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_+_161274684 5.768 NM_001127643
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr8_+_11561710 5.552 NM_002052
GATA4
GATA binding protein 4
chr12_-_93323088 5.510 NM_003566
EEA1
early endosome antigen 1
chr17_+_30813928 5.496 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr5_-_58334936 5.461 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr5_+_161275541 5.400 NM_001127645
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_29624249 5.365 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chrX_+_16737661 5.334 NM_032796
SYAP1
synapse associated protein 1
chr4_+_139936938 5.332 NM_012118
CCRN4L
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr4_-_87028805 5.271 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr9_-_23821842 5.075 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_-_45956795 5.072 NM_007170
TESK2
testis-specific kinase 2
chr6_+_72926144 4.800 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr8_+_38644721 4.671 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr2_+_210867321 4.584 NM_006916
RPE
ribulose-5-phosphate-3-epimerase
chr7_-_139876718 4.558 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr2_+_210867355 4.542 NM_199229
RPE
ribulose-5-phosphate-3-epimerase
chr2_-_200820458 4.539 NM_001039693
TYW5
tRNA-yW synthesizing protein 5
chr19_-_3700466 4.533 NM_001195733
NM_012398
PIP5K1C

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

chr15_-_64648359 4.496 NM_022048
CSNK1G1
casein kinase 1, gamma 1
chr4_-_87374282 4.482 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr8_+_42752019 4.441 NM_032410
HOOK3
hook homolog 3 (Drosophila)
chr5_+_161274939 4.399 NM_001127644
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr8_+_85095452 4.355 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chrX_+_68048792 4.343 NM_004429
EFNB1
ephrin-B1
chr8_+_85095501 4.299 NM_173848
RALYL
RALY RNA binding protein-like
chr19_+_37997840 4.209 NM_001013659
ZNF793
zinc finger protein 793
chr6_+_73076431 4.128 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr4_-_176734181 4.049 NM_201591
GPM6A
glycoprotein M6A
chr6_-_52860076 4.029 NM_001512
GSTA4
glutathione S-transferase alpha 4
chr8_+_85097099 3.931 NM_001100391
RALYL
RALY RNA binding protein-like
chr9_+_82186846 3.854 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_-_45815001 3.848 NM_013309
SLC30A4
solute carrier family 30 (zinc transporter), member 4
chr9_-_23821477 3.845 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_120548329 3.833 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chr8_+_38585703 3.726 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr1_+_26438267 3.710 NM_001243533
NM_152835
PDIK1L

PDLIM1 interacting kinase 1 like

chr12_+_32654976 3.702 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr17_+_29718641 3.565 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr5_+_112043188 3.561 NM_001127511
APC
adenomatous polyposis coli
chr1_+_97187174 3.542 NM_021190
PTBP2
polypyrimidine tract binding protein 2
chr4_-_87281374 3.512 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr5_+_161277391 3.497 NM_001127647
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr14_+_29236171 3.491 NM_005249
FOXG1
forkhead box G1
chr3_-_15374082 3.471 NM_004844
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr1_-_92371558 3.467 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr6_+_72926462 3.466 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr9_-_23826062 3.458 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr11_-_128392061 3.368 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr5_-_58652671 3.347 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_176923572 3.295 NM_005277
NM_201592
GPM6A

glycoprotein M6A

chrY_+_15016698 3.259 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr15_-_83953465 3.252 NM_001717
BNC1
basonuclin 1
chr13_-_107220444 3.156 NM_018011
ARGLU1
arginine and glutamate rich 1
chr16_+_55542909 3.152 NM_017839
LPCAT2
lysophosphatidylcholine acyltransferase 2
chr3_+_186501360 3.052 NM_001967
EIF4A2
eukaryotic translation initiation factor 4A2
chr18_-_74207145 3.039 NM_014643
ZNF516
zinc finger protein 516
chr6_+_126240369 3.034 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr5_-_58295758 3.009 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_+_72596648 2.950 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chrX_-_34675366 2.914 NM_031442
TMEM47
transmembrane protein 47
chr6_+_126111782 2.911 NM_001122842
NM_001199621
NM_181782
NCOA7


nuclear receptor coactivator 7


chr6_+_126102278 2.817 NM_001199619
NM_001199620
NCOA7

nuclear receptor coactivator 7

chr15_+_101142754 2.693 NM_024708
NM_198243
ASB7

ankyrin repeat and SOCS box containing 7

chr14_+_105780751 2.663 NM_001100913
NM_015197
PACS2

phosphofurin acidic cluster sorting protein 2

chr14_-_50698090 2.627 NM_006939
SOS2
son of sevenless homolog 2 (Drosophila)
chr7_-_120498128 2.615 NM_012338
TSPAN12
tetraspanin 12
chr5_+_112073555 2.612 NM_000038
NM_001127510
APC

adenomatous polyposis coli

chr1_-_92351613 2.592 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr10_-_35930357 2.568 NM_031866
FZD8
frizzled family receptor 8
chr12_+_122459791 2.560 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr11_-_70507911 2.543 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr4_-_120549115 2.529 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr16_+_1756161 2.454 NM_001040439
NM_015133
MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

chr1_+_145438437 2.446 NM_006472
TXNIP
thioredoxin interacting protein
chr21_-_19191643 2.444 NM_001100420
NM_001100421
NM_017447
C21orf91


chromosome 21 open reading frame 91


chr2_+_48541767 2.421 NM_002158
FOXN2
forkhead box N2
chrY_+_15016018 2.412 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr6_+_39760148 2.406 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr1_-_147232684 2.402 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr5_+_161275897 2.396 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_-_59064437 2.388 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_+_161277702 2.383 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_-_26277807 2.359 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr13_-_78549663 2.356 NM_000115
EDNRB
endothelin receptor type B
chr4_+_56212381 2.325 NM_024592
SRD5A3
steroid 5 alpha-reductase 3
chr15_-_49338496 2.285 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr3_-_15382874 2.260 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr11_-_10829519 2.226 NM_001172705
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chrX_-_112066353 2.216 NM_001113490
AMOT
angiomotin
chr8_-_67579446 2.194 NM_025054
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr18_-_25757351 2.164 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr22_+_29876180 2.130 NM_021076
NEFH
neurofilament, heavy polypeptide
chr6_+_133562488 2.042 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr3_+_14989076 2.016 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr4_+_156680125 1.931 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr2_-_109605668 1.904 NM_022336
EDAR
ectodysplasin A receptor
chr3_-_51533996 1.896 NM_001171904
NM_014703
VPRBP

Vpr (HIV-1) binding protein

chr16_+_54965110 1.890 NM_001252197
NM_005853
IRX5

iroquois homeobox 5

chr3_+_29322802 1.864 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr7_-_44924946 1.831 NM_033224
PURB
purine-rich element binding protein B
chr7_+_107384278 1.824 NM_024814
CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr17_+_26369617 1.733 NM_016231
NLK
nemo-like kinase
chr1_+_154300275 1.709 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr13_+_49549953 1.707 NM_001079673
FNDC3A
fibronectin type III domain containing 3A
chr9_+_101867401 1.701 NM_001130916
NM_004612
TGFBR1

transforming growth factor, beta receptor 1

chr22_-_46933066 1.669 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr10_+_74451838 1.646 NM_138357
MCU
mitochondrial calcium uniporter
chr4_+_37455551 1.641 NM_001104629
C4orf19
chromosome 4 open reading frame 19
chrX_-_112084006 1.632 NM_133265
AMOT
angiomotin
chr11_-_86666211 1.618 NM_012193
FZD4
frizzled family receptor 4
chr6_+_39760772 1.568 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr11_-_123525300 1.555 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr2_+_176981491 1.548 NM_002148
HOXD10
homeobox D10
chr6_+_37225506 1.513 NM_017772
TBC1D22B
TBC1 domain family, member 22B
chr18_-_57364643 1.480 NM_133459
CCBE1
collagen and calcium binding EGF domains 1
chr11_-_70935807 1.418 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chrX_+_30671456 1.400 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chrX_+_21392396 1.385 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr11_-_128457452 1.381 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr8_-_29120571 1.327 NM_015254
KIF13B
kinesin family member 13B
chr11_-_85376159 1.321 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr6_+_37137882 1.294 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr2_-_69870976 1.270 NM_014911
AAK1
AP2 associated kinase 1
chr4_-_120549827 1.268 NM_001083
PDE5A
phosphodiesterase 5A, cGMP-specific
chr8_+_67976561 1.256 NM_024790
CSPP1
centrosome and spindle pole associated protein 1
chr11_+_111848008 1.213 NM_033425
DIXDC1
DIX domain containing 1
chr1_+_19923457 1.187 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr16_+_1664640 1.167 NM_020825
CRAMP1L
Crm, cramped-like (Drosophila)
chr13_-_78493902 1.136 NM_001201397
EDNRB
endothelin receptor type B
chr16_-_4897265 1.084 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chrX_-_154114431 1.067 NM_019863
F8
coagulation factor VIII, procoagulant component
chr19_-_6459735 1.055 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr5_-_59189620 1.047 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_37034609 1.031 NM_014805
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr1_-_147245483 1.025 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr9_-_123476578 1.003 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr8_+_75262616 0.972 NM_018972
NM_001040875
GDAP1

ganglioside-induced differentiation-associated protein 1

chr14_+_103800492 0.965 NM_001969
EIF5
eukaryotic translation initiation factor 5
chr21_+_34697197 0.960 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr2_+_42396392 0.947 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr5_-_107006585 0.947 NM_001962
EFNA5
ephrin-A5
chr2_+_204192915 0.934 NM_005759
ABI2
abl-interactor 2
chr13_-_78492906 0.888 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr2_-_201936389 0.878 NM_173822
FAM126B
family with sequence similarity 126, member B
chr8_+_79428335 0.831 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr11_-_129872719 0.798 NM_020228
NM_199437
PRDM10

PR domain containing 10

chr12_-_12419702 0.754 NM_002336
LRP6
low density lipoprotein receptor-related protein 6
chr7_+_90338711 0.745 NM_012395
CDK14
cyclin-dependent kinase 14
chr1_-_226128872 0.745 NM_001172425
NM_003240
LEFTY2

left-right determination factor 2

chr20_-_32274154 0.717 NM_005225
E2F1
E2F transcription factor 1
chr2_-_214016332 0.704 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr15_-_34502269 0.687 NM_024713
C15orf29
chromosome 15 open reading frame 29
chr2_+_226265601 0.679 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr19_+_10764896 0.635 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr11_-_118047336 0.614 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chrX_-_154250769 0.610 NM_000132
F8
coagulation factor VIII, procoagulant component
chr1_+_100598705 0.602 NM_019083
CCDC76
coiled-coil domain containing 76
chr14_-_61115906 0.580 NM_005982
SIX1
SIX homeobox 1
chr17_-_62050200 0.574 NM_000334
SCN4A
sodium channel, voltage-gated, type IV, alpha subunit
chr2_+_239229140 0.544 NM_001139490
NM_015650
TRAF3IP1

TNF receptor-associated factor 3 interacting protein 1

chr5_-_58882274 0.526 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58571916 0.523 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_36531767 0.497 NM_004620
NM_145803
TRAF6

TNF receptor-associated factor 6

chr2_+_32288579 0.485 NM_014946
NM_199436
SPAST

spastin

chr3_+_61547179 0.484 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr3_-_15563160 0.476 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr1_-_209979388 0.450 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr12_+_99038918 0.405 NM_001160
NM_013229
NM_181861
NM_181868
NM_181869
APAF1




apoptotic peptidase activating factor 1




chr6_+_3118861 0.404 NM_004332
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr3_+_89156673 0.403 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr6_+_42123143 0.372 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr6_+_83777361 0.370 NM_001199942
NM_015018
DOPEY1

dopey family member 1

chr13_+_49684388 0.305 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr6_-_13711643 0.275 NM_005493
RANBP9
RAN binding protein 9
chr19_-_7293876 0.254 NM_000208
NM_001079817
INSR

insulin receptor

chr2_+_228029280 0.234 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr1_-_21113160 0.226 NM_016287
HP1BP3
heterochromatin protein 1, binding protein 3
chr3_-_15540378 0.212 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr11_+_111807857 0.201 NM_001037954
DIXDC1
DIX domain containing 1
chr3_-_56717132 0.199 NM_001112736
FAM208A
family with sequence similarity 208, member A
chr21_-_39870303 0.157 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.91 1.61e-05 GO:0007399 nervous system development
2.16 9.89e-05 GO:0048731 system development
3.41 1.10e-04 GO:0022008 neurogenesis
3.47 1.56e-04 GO:0048699 generation of neurons
2.71 2.41e-04 GO:0009653 anatomical structure morphogenesis
1.96 3.38e-04 GO:0007275 multicellular organismal development
2.02 3.62e-04 GO:0048856 anatomical structure development
2.30 1.17e-03 GO:0030154 cell differentiation
2.35 1.56e-03 GO:0048513 organ development
2.23 2.24e-03 GO:0048869 cellular developmental process
3.27 4.77e-03 GO:2000026 regulation of multicellular organismal development
1.79 6.25e-03 GO:0032502 developmental process
7.07 1.57e-02 GO:0016055 Wnt receptor signaling pathway
1.58 1.97e-02 GO:0032501 multicellular organismal process
2.82 2.33e-02 GO:0048468 cell development
3.16 2.40e-02 GO:0030182 neuron differentiation
13.24 3.10e-02 GO:0060041 retina development in camera-type eye
2.86 3.14e-02 GO:0040011 locomotion
2.17 3.36e-02 GO:0007166 cell surface receptor linked signaling pathway

Nothing significant found in compartment category.

Nothing significant found in function category.