Motif ID: AAAGUGC

Z-value: 1.746


Mature miRNA associated with seed AAAGUGC:

NamemiRBase Accession
hsa-miR-106a MIMAT0000103
hsa-miR-106b MIMAT0000680
hsa-miR-17 MIMAT0000070
hsa-miR-20a MIMAT0000075
hsa-miR-20b MIMAT0001413
hsa-miR-519d MIMAT0002853
hsa-miR-93 MIMAT0000093



Activity profile for motif AAAGUGC.

activity profile for motif AAAGUGC


Sorted Z-values histogram for motif AAAGUGC

Sorted Z-values for motif AAAGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAAGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_204380903 49.622 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr18_+_21594349 49.615 NM_001135993
NM_001243425
TTC39C

tetratricopeptide repeat domain 39C

chr14_+_92790151 38.170 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr10_-_61469322 36.749 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr14_+_92789536 33.744 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr18_+_21572736 33.601 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr11_-_113746205 31.267 NM_020886
USP28
ubiquitin specific peptidase 28
chr18_-_13726582 27.767 NM_001098801
NM_152352
FAM210A

family with sequence similarity 210, member A

chr14_+_92788924 26.548 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chrX_-_54384436 25.623 NM_001002838
NM_020922
WNK3

WNK lysine deficient protein kinase 3

chr8_+_26435339 23.881 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr2_+_10183630 23.851 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr2_+_203499819 22.221 NM_173511
FAM117B
family with sequence similarity 117, member B
chr19_-_49944613 21.537 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr12_-_16760935 21.043 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr13_+_113623496 20.890 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr4_+_7045142 20.797 NM_152293
TADA2B
transcriptional adaptor 2B
chr10_-_120514669 20.150 NM_153810
C10orf46
chromosome 10 open reading frame 46
chr14_-_45431121 19.818 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr16_-_2264776 19.774 NM_001042371
PGP
phosphoglycolate phosphatase
chr7_+_108210188 19.165 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr17_+_36507708 18.674 NM_014598
SOCS7
suppressor of cytokine signaling 7
chr3_+_101443436 18.525 NM_024548
CEP97
centrosomal protein 97kDa
chr11_+_45868956 18.524 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr17_-_28257017 18.367 NM_033389
SSH2
slingshot homolog 2 (Drosophila)
chr7_-_111846384 18.346 NM_014705
DOCK4
dedicator of cytokinesis 4
chr22_-_22089975 18.262 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr8_+_26371461 18.234 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr20_-_4804067 17.817 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr15_+_68871285 17.756 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr6_+_107811272 17.647 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr19_+_18208596 17.557 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr6_-_152958533 17.186 NM_182961
SYNE1
spectrin repeat containing, nuclear envelope 1
chr12_-_16759531 16.971 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr15_+_68924326 16.803 NM_001190457
CORO2B
coronin, actin binding protein, 2B
chr16_+_85061303 16.685 NM_014732
KIAA0513
KIAA0513
chr11_+_45868668 16.649 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr16_-_2185824 16.509 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr1_+_145438437 16.118 NM_006472
TXNIP
thioredoxin interacting protein
chr15_+_68908878 15.564 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr3_-_15140652 15.329 NM_022340
ZFYVE20
zinc finger, FYVE domain containing 20
chr15_+_99645152 15.307 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr1_-_23857711 15.236 NM_004091
E2F2
E2F transcription factor 2
chr11_-_18655962 15.206 NM_194285
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr3_-_13114547 15.202 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr2_-_222436996 15.076 NM_004438
EPHA4
EPH receptor A4
chr6_-_152957985 14.964 NM_033071
SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_+_76156059 14.923 NM_020193
C11orf30
chromosome 11 open reading frame 30
chr3_+_169490852 14.832 NM_001185118
NM_018657
MYNN

myoneurin

chr3_-_57113292 14.793 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr20_-_47894591 14.781 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chr17_+_17942584 14.697 NM_024052
C17orf39
chromosome 17 open reading frame 39
chr13_-_26796343 14.612 NM_005977
RNF6
ring finger protein (C3H2C3 type) 6
chr12_+_32654976 14.596 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr5_-_134914968 14.452 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr17_-_37764165 14.213 NM_006160
NEUROD2
neurogenic differentiation 2
chr2_-_73298815 14.203 NM_144579
SFXN5
sideroflexin 5
chr19_-_344778 14.160 NM_017550
MIER2
mesoderm induction early response 1, family member 2
chr2_+_25016174 13.944 NM_001199803
NM_024322
CENPO

centromere protein O

chr5_+_72921980 13.885 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr17_-_66287256 13.778 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr2_+_74273449 13.750 NM_144993
TET3
tet methylcytosine dioxygenase 3
chr15_+_65134081 13.545 NM_001195059
NM_025201
PLEKHO2

pleckstrin homology domain containing, family O member 2

chr14_-_53620032 13.519 NM_001160147
NM_001160148
NM_030637
DDHD1


DDHD domain containing 1


chr6_-_167040700 13.480 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr9_+_99212379 13.399 NM_014282
HABP4
hyaluronan binding protein 4
chr20_-_4795768 13.303 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr2_+_24163267 13.094 NM_181713
UBXN2A
UBX domain protein 2A
chr17_+_7184978 13.087 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr12_+_122064448 13.059 NM_032790
ORAI1
ORAI calcium release-activated calcium modulator 1
chr17_+_53342320 13.026 NM_002126
HLF
hepatic leukemia factor
chr17_+_29718641 12.793 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr7_-_44924946 12.784 NM_033224
PURB
purine-rich element binding protein B
chr12_-_42538432 12.760 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr7_+_149535508 12.634 NM_001099220
ZNF862
zinc finger protein 862
chr4_+_53728481 12.576 NM_023940
RASL11B
RAS-like, family 11, member B
chr11_+_14665268 12.486 NM_000922
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr12_-_93323088 12.422 NM_003566
EEA1
early endosome antigen 1
chr9_+_82186846 12.412 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_+_57943843 12.366 NM_004984
KIF5A
kinesin family member 5A
chr19_+_50380681 12.267 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chrX_+_16737661 12.249 NM_032796
SYAP1
synapse associated protein 1
chr9_-_101470836 12.245 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr13_+_42846255 12.183 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chr13_+_27131799 12.129 NM_006646
WASF3
WAS protein family, member 3
chr15_-_64648359 11.603 NM_022048
CSNK1G1
casein kinase 1, gamma 1
chr5_-_65017874 11.591 NM_019072
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr12_+_72233486 11.583 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr6_+_139456240 11.394 NM_016217
HECA
headcase homolog (Drosophila)
chr11_-_1330891 11.391 NM_019009
TOLLIP
toll interacting protein
chr2_-_157189040 11.370 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_3569098 11.366 NM_001204184
NM_001204185
NM_001204186
NM_001204187
NM_001204188
NM_005427
TP73





tumor protein p73





chr1_-_230513390 11.351 NM_024554
PGBD5
piggyBac transposable element derived 5
chr7_-_22396511 11.320 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr2_+_70142152 11.238 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chrX_+_133507299 11.161 NM_001015877
NM_032335
NM_032458
PHF6


PHD finger protein 6


chr11_+_121322848 11.152 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr4_+_6271558 11.066 NM_001145853
NM_006005
WFS1

Wolfram syndrome 1 (wolframin)

chr2_+_16080639 11.062 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr1_+_6845381 11.040 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr16_+_19125243 11.004 NM_001034841
ITPRIPL2
inositol 1,4,5-trisphosphate receptor interacting protein-like 2
chr20_+_32951054 11.003 NM_031483
ITCH
itchy E3 ubiquitin protein ligase homolog (mouse)
chr13_+_35516390 10.996 NM_015678
NBEA
neurobeachin
chr14_+_71108373 10.972 NM_015351
TTC9
tetratricopeptide repeat domain 9
chr17_+_8339135 10.954 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr4_+_156588811 10.941 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr10_+_120789227 10.925 NM_199461
NANOS1
nanos homolog 1 (Drosophila)
chr3_-_53080038 10.916 NM_001005158
NM_016329
SFMBT1

Scm-like with four mbt domains 1

chr11_-_108093328 10.735 NM_002519
NPAT
nuclear protein, ataxia-telangiectasia locus
chr19_+_38397841 10.721 NM_015073
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr3_-_13008959 10.720 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr7_+_100136784 10.696 NM_006076
AGFG2
ArfGAP with FG repeats 2
chr5_-_174871162 10.671 NM_000794
DRD1
dopamine receptor D1
chr10_+_86088156 10.664 NM_018999
FAM190B
family with sequence similarity 190, member B
chr4_-_36245893 10.611 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_+_55512801 10.597 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_-_65431826 10.471 NM_002227
JAK1
Janus kinase 1
chr4_+_126237566 10.198 NM_024582
FAT4
FAT tumor suppressor homolog 4 (Drosophila)
chr4_+_72052354 10.187 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr5_-_39425297 10.176 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr7_-_99756275 10.130 NM_018275
C7orf43
chromosome 7 open reading frame 43
chr14_-_34419957 10.114 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr9_-_130742803 10.083 NM_001035254
FAM102A
family with sequence similarity 102, member A
chr3_-_170626425 10.027 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr18_+_48556483 10.021 NM_005359
SMAD4
SMAD family member 4
chr1_+_19971865 10.012 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr1_-_47184730 10.000 NM_014774
KIAA0494
KIAA0494
chr1_+_183605207 9.893 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr2_-_206950895 9.881 NM_017759
INO80D
INO80 complex subunit D
chr14_+_69865380 9.818 NM_001252148
NM_001252150
NM_018375
SLC39A9


solute carrier family 39 (zinc transporter), member 9


chr11_-_1593149 9.782 NM_004420
DUSP8
dual specificity phosphatase 8
chr11_-_46722115 9.760 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr15_+_91643429 9.758 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr12_-_50297575 9.712 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr13_-_26795927 9.704 NM_183043
RNF6
ring finger protein (C3H2C3 type) 6
chr2_-_68694389 9.633 NM_001024680
FBXO48
F-box protein 48
chr13_+_113656027 9.631 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr16_+_1664640 9.595 NM_020825
CRAMP1L
Crm, cramped-like (Drosophila)
chr4_+_55095263 9.495 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr14_+_74111577 9.460 NM_001201366
NM_031427
DNAL1

dynein, axonemal, light chain 1

chr4_-_170947428 9.455 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr16_+_53468344 9.444 NM_005611
RBL2
retinoblastoma-like 2 (p130)
chr15_+_85923739 9.431 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr7_-_4901437 9.428 NM_020144
PAPOLB
poly(A) polymerase beta (testis specific)
chr17_-_43568124 9.424 NM_014798
PLEKHM1
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr3_-_129612371 9.388 NM_001128224
TMCC1
transmembrane and coiled-coil domain family 1
chr8_+_42752019 9.362 NM_032410
HOOK3
hook homolog 3 (Drosophila)
chr10_-_30348433 9.355 NM_020848
KIAA1462
KIAA1462
chr15_+_92937104 9.300 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr7_-_14031049 9.257 NM_001163148
ETV1
ets variant 1
chr12_+_4382882 9.185 NM_001759
CCND2
cyclin D2
chrX_-_53310748 9.181 NM_001243197
NM_015075
IQSEC2

IQ motif and Sec7 domain 2

chr20_+_1875825 9.151 NM_001040023
SIRPA
signal-regulatory protein alpha
chr11_-_6494985 9.119 NM_001248007
NM_006458
NM_033278
TRIM3


tripartite motif containing 3


chr2_-_201936389 9.113 NM_173822
FAM126B
family with sequence similarity 126, member B
chr11_-_70507911 9.068 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr3_-_15374082 9.009 NM_004844
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr5_-_693413 8.894 NM_007030
TPPP
tubulin polymerization promoting protein
chr5_-_134871638 8.877 NM_006161
NEUROG1
neurogenin 1
chr1_+_160336856 8.841 NM_005598
NHLH1
nescient helix loop helix 1
chr17_+_4736612 8.807 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr14_-_73360792 8.770 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr11_-_74109417 8.763 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr15_-_77712436 8.755 NM_024776
PEAK1
NKF3 kinase family member
chr5_-_171433876 8.751 NM_012300
NM_033644
NM_033645
FBXW11


F-box and WD repeat domain containing 11


chr12_-_110434187 8.712 NM_001135213
NM_001135214
NM_014776
NM_057169
NM_057170
NM_139201
GIT2





G protein-coupled receptor kinase interacting ArfGAP 2





chr3_-_56835829 8.653 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr4_-_56412968 8.650 NM_004898
CLOCK
clock homolog (mouse)
chr8_+_28747885 8.552 NM_001135726
HMBOX1
homeobox containing 1
chr17_-_40897025 8.481 NM_001991
EZH1
enhancer of zeste homolog 1 (Drosophila)
chr9_-_36400817 8.414 NM_194328
NM_194332
RNF38

ring finger protein 38

chr1_-_25573933 8.393 NM_020317
C1orf63
chromosome 1 open reading frame 63
chr6_-_136871956 8.369 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr4_+_72204769 8.362 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr2_+_220042901 8.347 NM_024293
FAM134A
family with sequence similarity 134, member A
chr15_+_66994669 8.224 NM_005585
SMAD6
SMAD family member 6
chr5_+_140345746 8.192 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr3_-_145968958 8.164 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr2_-_197036301 8.161 NM_004226
STK17B
serine/threonine kinase 17b
chr9_-_130712866 8.158 NM_203305
FAM102A
family with sequence similarity 102, member A
chr7_+_86781869 8.102 NM_021145
DMTF1
cyclin D binding myb-like transcription factor 1
chr17_-_4890664 8.095 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr3_+_14989076 8.078 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr13_-_29292961 8.065 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr9_+_136397285 8.053 NM_001145320
ADAMTSL2
ADAMTS-like 2
chr1_-_23495347 8.038 NM_001142546
NM_033631
LUZP1

leucine zipper protein 1

chr2_-_240322620 7.984 NM_006037
HDAC4
histone deacetylase 4
chr4_-_44728518 7.956 NM_138335
GNPDA2
glucosamine-6-phosphate deaminase 2
chr13_+_39612440 7.927 NM_001012754
NM_001017370
NHLRC3

NHL repeat containing 3

chr19_+_14016955 7.923 NM_017721
CC2D1A
coiled-coil and C2 domain containing 1A
chr2_+_10184371 7.899 NM_001177718
KLF11
Kruppel-like factor 11
chr11_-_73309090 7.888 NM_015159
FAM168A
family with sequence similarity 168, member A
chr15_+_91643181 7.851 NM_001167580
SV2B
synaptic vesicle glycoprotein 2B
chr1_+_52608045 7.831 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr1_+_19970207 7.721 NM_001204084
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr7_-_100425035 7.686 NM_004444
EPHB4
EPH receptor B4
chr8_-_9009050 7.643 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr2_-_96811138 7.633 NM_004418
DUSP2
dual specificity phosphatase 2
chr3_-_149688638 7.609 NM_002628
NM_053024
PFN2

profilin 2

chr12_+_69864065 7.583 NM_001042555
NM_006654
FRS2

fibroblast growth factor receptor substrate 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.46 3.02e-13 GO:0009966 regulation of signal transduction
1.46 1.93e-12 GO:0050794 regulation of cellular process
2.36 4.49e-12 GO:0007399 nervous system development
2.27 5.11e-12 GO:0023051 regulation of signaling
1.86 4.21e-11 GO:0048731 system development
1.42 6.90e-11 GO:0050789 regulation of biological process
1.92 1.77e-10 GO:0048522 positive regulation of cellular process
1.70 1.83e-10 GO:0023052 signaling
1.38 2.91e-10 GO:0065007 biological regulation
2.07 4.53e-10 GO:0048583 regulation of response to stimulus
1.76 5.14e-10 GO:0048856 anatomical structure development
1.72 1.02e-09 GO:0007165 signal transduction
1.83 1.37e-09 GO:0048518 positive regulation of biological process
1.65 2.62e-09 GO:0032502 developmental process
1.68 9.15e-09 GO:0007275 multicellular organismal development
2.46 1.16e-08 GO:0006793 phosphorus metabolic process
2.46 1.16e-08 GO:0006796 phosphate metabolic process
2.21 1.42e-08 GO:0035556 intracellular signal transduction
2.71 3.64e-08 GO:0006468 protein phosphorylation
3.55 4.96e-08 GO:0051056 regulation of small GTPase mediated signal transduction
2.57 5.98e-08 GO:0016310 phosphorylation
2.80 1.01e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.63 1.27e-07 GO:0080090 regulation of primary metabolic process
1.62 1.91e-07 GO:0031323 regulation of cellular metabolic process
1.56 2.19e-07 GO:0051716 cellular response to stimulus
1.56 6.28e-07 GO:0019222 regulation of metabolic process
1.85 8.70e-07 GO:0030154 cell differentiation
1.69 3.75e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.80 3.97e-06 GO:0048869 cellular developmental process
3.83 4.82e-06 GO:0046578 regulation of Ras protein signal transduction
1.86 6.36e-06 GO:0006464 protein modification process
2.63 6.87e-06 GO:0045893 positive regulation of transcription, DNA-dependent
2.54 9.86e-06 GO:0010628 positive regulation of gene expression
1.65 1.20e-05 GO:0051171 regulation of nitrogen compound metabolic process
2.38 1.87e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
2.40 1.87e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.20 2.00e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.03 2.22e-05 GO:0009893 positive regulation of metabolic process
2.31 2.72e-05 GO:0031328 positive regulation of cellular biosynthetic process
2.40 2.88e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.72 2.90e-05 GO:0051252 regulation of RNA metabolic process
1.73 3.01e-05 GO:0006355 regulation of transcription, DNA-dependent
1.19 3.19e-05 GO:0009987 cellular process
1.55 4.06e-05 GO:0060255 regulation of macromolecule metabolic process
1.78 4.13e-05 GO:0043412 macromolecule modification
2.25 4.64e-05 GO:0006351 transcription, DNA-dependent
2.27 4.81e-05 GO:0009891 positive regulation of biosynthetic process
1.65 5.72e-05 GO:0010468 regulation of gene expression
2.45 5.80e-05 GO:0051254 positive regulation of RNA metabolic process
2.03 6.52e-05 GO:0031325 positive regulation of cellular metabolic process
1.96 1.11e-04 GO:0051239 regulation of multicellular organismal process
1.65 1.29e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
3.03 1.40e-04 GO:0006917 induction of apoptosis
3.03 1.50e-04 GO:0012502 induction of programmed cell death
2.83 1.62e-04 GO:0007243 intracellular protein kinase cascade
2.83 1.62e-04 GO:0023014 signal transduction via phosphorylation event
2.16 1.66e-04 GO:0022008 neurogenesis
1.59 3.26e-04 GO:0031326 regulation of cellular biosynthetic process
1.61 5.01e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.96 5.86e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.57 5.89e-04 GO:0009889 regulation of biosynthetic process
2.55 6.01e-04 GO:0043068 positive regulation of programmed cell death
2.23 6.61e-04 GO:2000026 regulation of multicellular organismal development
2.53 6.67e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.59 8.33e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.50 9.06e-04 GO:0010942 positive regulation of cell death
2.03 1.30e-03 GO:0032774 RNA biosynthetic process
2.49 1.46e-03 GO:0043065 positive regulation of apoptosis
1.71 1.50e-03 GO:0007166 cell surface receptor linked signaling pathway
1.96 1.82e-03 GO:0010941 regulation of cell death
2.08 2.07e-03 GO:0048699 generation of neurons
2.04 2.16e-03 GO:0050793 regulation of developmental process
2.47 2.59e-03 GO:0000904 cell morphogenesis involved in differentiation
1.67 2.74e-03 GO:0048513 organ development
2.21 3.56e-03 GO:0042325 regulation of phosphorylation
2.20 4.19e-03 GO:0045595 regulation of cell differentiation
2.37 4.42e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.60 5.04e-03 GO:0048523 negative regulation of cellular process
1.92 5.22e-03 GO:0043067 regulation of programmed cell death
1.38 6.22e-03 GO:0044260 cellular macromolecule metabolic process
2.32 6.97e-03 GO:0051253 negative regulation of RNA metabolic process
2.15 7.32e-03 GO:0019220 regulation of phosphate metabolic process
2.15 7.32e-03 GO:0051174 regulation of phosphorus metabolic process
1.33 8.51e-03 GO:0032501 multicellular organismal process
1.90 8.62e-03 GO:0042981 regulation of apoptosis
2.57 1.02e-02 GO:0007264 small GTPase mediated signal transduction
1.72 1.12e-02 GO:0009653 anatomical structure morphogenesis
5.77 1.39e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.86 1.69e-02 GO:0010646 regulation of cell communication
2.98 1.71e-02 GO:0000165 MAPKKK cascade
2.09 1.79e-02 GO:0030182 neuron differentiation
2.65 1.91e-02 GO:0009894 regulation of catabolic process
5.02 1.96e-02 GO:0046777 protein autophosphorylation
2.17 2.30e-02 GO:0010629 negative regulation of gene expression
2.56 2.38e-02 GO:0007420 brain development
1.52 2.53e-02 GO:0048519 negative regulation of biological process
2.28 2.64e-02 GO:0007417 central nervous system development
2.40 2.70e-02 GO:0032583 regulation of gene-specific transcription
2.13 2.77e-02 GO:0001932 regulation of protein phosphorylation
3.48 2.83e-02 GO:0048511 rhythmic process
13.69 3.09e-02 GO:0043550 regulation of lipid kinase activity
1.87 3.34e-02 GO:0032879 regulation of localization
2.29 3.49e-02 GO:0043549 regulation of kinase activity
1.68 4.02e-02 GO:0065009 regulation of molecular function
12.64 4.90e-02 GO:0045022 early endosome to late endosome transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 2.07e-05 GO:0005634 nucleus
1.16 4.55e-05 GO:0005622 intracellular
1.16 1.46e-04 GO:0044424 intracellular part
1.53 3.98e-03 GO:0044459 plasma membrane part
1.71 4.69e-03 GO:0005654 nucleoplasm
1.70 9.51e-03 GO:0031226 intrinsic to plasma membrane
1.70 1.04e-02 GO:0005887 integral to plasma membrane
1.07 1.16e-02 GO:0044464 cell part
1.07 1.18e-02 GO:0005623 cell
1.53 2.38e-02 GO:0031981 nuclear lumen
4.32 2.60e-02 GO:0033267 axon part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.92 4.38e-09 GO:0005083 small GTPase regulator activity
1.20 6.27e-09 GO:0005488 binding
2.37 1.75e-08 GO:0001071 nucleic acid binding transcription factor activity
2.37 1.75e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
2.62 3.04e-08 GO:0016773 phosphotransferase activity, alcohol group as acceptor
2.77 4.88e-08 GO:0004672 protein kinase activity
1.35 5.16e-08 GO:0005515 protein binding
2.96 4.00e-07 GO:0030695 GTPase regulator activity
2.44 4.25e-07 GO:0016301 kinase activity
2.88 8.68e-07 GO:0060589 nucleoside-triphosphatase regulator activity
4.55 1.26e-06 GO:0005085 guanyl-nucleotide exchange factor activity
2.90 2.96e-06 GO:0004674 protein serine/threonine kinase activity
5.59 3.38e-06 GO:0005057 receptor signaling protein activity
5.78 5.62e-06 GO:0005088 Ras guanyl-nucleotide exchange factor activity
13.84 1.57e-05 GO:0004709 MAP kinase kinase kinase activity
2.14 1.71e-05 GO:0030234 enzyme regulator activity
2.14 2.74e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
7.38 7.70e-05 GO:0004702 receptor signaling protein serine/threonine kinase activity
1.44 1.03e-04 GO:0046872 metal ion binding
2.00 1.55e-04 GO:0030528 transcription regulator activity
2.18 1.98e-04 GO:0019899 enzyme binding
1.43 2.13e-04 GO:0043169 cation binding
1.42 2.49e-04 GO:0043167 ion binding
5.40 7.63e-04 GO:0005089 Rho guanyl-nucleotide exchange factor activity
6.44 1.04e-03 GO:0003707 steroid hormone receptor activity
6.09 1.80e-03 GO:0004879 ligand-dependent nuclear receptor activity
6.57 2.79e-03 GO:0046332 SMAD binding
2.76 3.18e-03 GO:0008134 transcription factor binding
14.94 4.00e-03 GO:0070411 I-SMAD binding
1.51 6.28e-03 GO:0003677 DNA binding
4.58 1.04e-02 GO:0031625 ubiquitin protein ligase binding
4.46 1.33e-02 GO:0019199 transmembrane receptor protein kinase activity
1.99 1.50e-02 GO:0043565 sequence-specific DNA binding
2.52 2.04e-02 GO:0016564 transcription repressor activity
1.55 3.31e-02 GO:0016740 transferase activity
14.60 3.71e-02 GO:0051019 mitogen-activated protein kinase binding