Motif ID: AAGGUGC

Z-value: 0.800


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a MIMAT0000072
hsa-miR-18b MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_186877869 8.859 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186732208 8.673 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186733372 8.629 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr4_-_186732047 7.918 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186697065 7.846 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr3_+_107241782 7.843 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr4_-_186578122 7.651 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr6_-_132272311 6.752 NM_001901
CTGF
connective tissue growth factor
chr15_-_60919642 5.452 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr5_-_142815076 5.387 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr15_-_60884615 5.340 NM_134262
RORA
RAR-related orphan receptor A
chr15_-_61521478 5.268 NM_134261
RORA
RAR-related orphan receptor A
chr5_-_142783975 4.801 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_-_142783225 4.376 NM_000176
NM_001020825
NM_001024094
NM_001204258
NM_001204259
NM_001204260
NM_001204261
NM_001204262
NM_001204263
NM_001204264
NM_001204265
NR3C1










nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)










chr22_+_38092994 4.241 NM_001039141
TRIOBP
TRIO and F-actin binding protein
chr6_-_11382501 4.173 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_+_39760148 4.007 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_+_138188352 3.862 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_-_161993586 3.816 NM_015441
OLFML2B
olfactomedin-like 2B
chr3_-_124774735 3.719 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr6_+_39760772 3.629 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr3_+_187871473 3.489 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_+_171757413 3.464 NM_022763
FNDC3B
fibronectin type III domain containing 3B
chr12_+_12764755 3.454 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr3_+_187943192 3.374 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_48423382 2.967 NM_022167
XYLT2
xylosyltransferase II
chr22_+_40573879 2.962 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_+_171758289 2.847 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr3_+_187930720 2.785 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_163038395 2.745 NM_001102445
RGS4
regulator of G-protein signaling 4
chr2_+_12856813 2.674 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr18_-_45457454 2.642 NM_001003652
NM_001135937
SMAD2

SMAD family member 2

chr7_+_66386129 2.610 NM_017994
C7orf42
chromosome 7 open reading frame 42
chr2_+_36583369 2.560 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr1_+_163041694 2.547 NM_001113380
RGS4
regulator of G-protein signaling 4
chr19_+_50879681 2.522 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr11_+_108093558 2.501 NM_000051
ATM
ataxia telangiectasia mutated
chr6_-_11232901 2.469 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr9_-_132805456 2.437 NM_015033
FNBP1
formin binding protein 1
chr16_+_30960377 2.388 NM_152288
ORAI3
ORAI calcium release-activated calcium modulator 3
chr10_-_81205091 2.345 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr1_+_163038934 2.305 NM_001113381
RGS4
regulator of G-protein signaling 4
chr1_+_163038564 2.238 NM_005613
RGS4
regulator of G-protein signaling 4
chr22_+_40440664 2.205 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr6_-_16761600 2.118 NM_000332
NM_001128164
ATXN1

ataxin 1

chr3_+_43328001 2.071 NM_001100594
NM_017719
SNRK

SNF related kinase

chr16_+_28996369 2.057 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr15_-_34610928 1.995 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr1_-_202777545 1.934 NM_006618
KDM5B
lysine (K)-specific demethylase 5B
chr15_-_34630203 1.923 NM_001042495
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr22_+_38142230 1.909 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr12_-_15038724 1.889 NM_000900
NM_001190839
MGP

matrix Gla protein

chr10_+_111767685 1.861 NM_001121
NM_016824
ADD3

adducin 3 (gamma)

chr15_-_34629044 1.821 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr19_-_23578226 1.777 NM_003430
ZNF91
zinc finger protein 91
chr14_-_95608054 1.764 NM_030621
DICER1
dicer 1, ribonuclease type III
chr18_-_45456925 1.762 NM_005901
SMAD2
SMAD family member 2
chr14_-_95623665 1.715 NM_177438
DICER1
dicer 1, ribonuclease type III
chr1_+_32573619 1.701 NM_012316
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr5_-_151066492 1.679 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr14_+_62162042 1.670 NM_001530
NM_181054
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr5_-_142077508 1.657 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr2_+_24807345 1.635 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr12_+_104458235 1.624 NM_013320
HCFC2
host cell factor C2
chr11_-_116968986 1.610 NM_025164
SIK3
SIK family kinase 3
chr10_+_111765725 1.533 NM_019903
ADD3
adducin 3 (gamma)
chr5_-_58334936 1.474 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr15_-_23086290 1.402 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr5_-_141993691 1.393 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr3_+_151985828 1.390 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr10_-_119805673 1.376 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr14_-_95599794 1.240 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr2_+_30369749 1.205 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr1_+_145438437 1.185 NM_006472
TXNIP
thioredoxin interacting protein
chr17_+_40834571 1.147 NM_003632
CNTNAP1
contactin associated protein 1
chr15_+_39873276 1.147 NM_003246
THBS1
thrombospondin 1
chr3_-_123603144 1.129 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr12_+_4382882 1.120 NM_001759
CCND2
cyclin D2
chr3_+_127771126 1.115 NM_013336
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr15_-_34629941 1.089 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr9_-_74383301 1.063 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr1_+_36621751 1.057 NM_018067
MAP7D1
MAP7 domain containing 1
chr16_+_28996146 1.049 NM_001014989
LAT
linker for activation of T cells
chr11_-_2162340 1.046 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_+_152017193 1.025 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr1_-_120612301 1.024 NM_001200001
NM_024408
NOTCH2

notch 2

chr20_+_43595119 1.022 NM_006282
STK4
serine/threonine kinase 4
chr5_+_141488314 0.988 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr11_-_2160199 0.978 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_123339423 0.971 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr5_-_142065586 0.968 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr5_-_142065991 0.955 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr17_-_62340652 0.952 NM_018469
TEX2
testis expressed 2
chr11_-_2170792 0.950 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr13_+_42031525 0.948 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr7_+_117864711 0.946 NM_019644
ANKRD7
ankyrin repeat domain 7
chr9_+_118916069 0.920 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr5_+_31799030 0.913 NM_178140
PDZD2
PDZ domain containing 2
chr9_-_138987096 0.909 NM_144653
NACC2
NACC family member 2, BEN and BTB (POZ) domain containing
chr2_-_87035518 0.899 NM_001145873
CD8A
CD8a molecule
chr6_-_108395939 0.883 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr19_+_3572903 0.879 NM_006339
HMG20B
high mobility group 20B
chr2_-_87018802 0.875 NM_001768
NM_171827
CD8A

CD8a molecule

chr6_-_111136407 0.839 NM_015076
CDK19
cyclin-dependent kinase 19
chr1_-_89530890 0.794 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr5_-_142000899 0.790 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr17_-_76921453 0.784 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_95007139 0.783 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr15_+_63569748 0.774 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr2_-_153032141 0.768 NM_005843
STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr4_-_185395616 0.752 NM_002199
IRF2
interferon regulatory factor 2
chr12_+_54943176 0.747 NM_000924
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr4_-_83812334 0.744 NM_001191049
SEC31A
SEC31 homolog A (S. cerevisiae)
chr20_-_43977023 0.731 NM_002999
SDC4
syndecan 4
chr4_+_55523906 0.695 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr14_+_55738871 0.689 NM_152231
FBXO34
F-box protein 34
chr6_+_26365397 0.683 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr13_+_48807250 0.683 NM_021999
ITM2B
integral membrane protein 2B
chr4_-_83812372 0.682 NM_001077206
NM_001077207
NM_001077208
NM_016211
NM_014933
SEC31A




SEC31 homolog A (S. cerevisiae)




chr6_-_116601102 0.676 NM_003309
TSPYL1
TSPY-like 1
chr6_-_52441815 0.634 NM_012288
TRAM2
translocation associated membrane protein 2
chr2_+_28615771 0.630 NM_005253
FOSL2
FOS-like antigen 2
chr12_+_108956293 0.622 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr5_-_59783885 0.617 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_30156326 0.613 NM_024310
PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr6_+_26368405 0.611 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr6_+_26440699 0.610 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr22_+_17565844 0.604 NM_014339
IL17RA
interleukin 17 receptor A
chr6_+_19837599 0.594 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr5_-_59064437 0.585 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_40307015 0.579 NM_001252039
NM_004583
NM_201434
RAB5C


RAB5C, member RAS oncogene family


chr4_+_183245136 0.571 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr3_-_119812973 0.571 NM_001146156
NM_002093
GSK3B

glycogen synthase kinase 3 beta

chr13_-_38172862 0.559 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_+_233561997 0.547 NM_001103146
NM_001103147
NM_001103148
NM_015575
GIGYF2



GRB10 interacting GYF protein 2



chr1_+_65886130 0.537 NM_001198683
NM_017526
LEPROT

leptin receptor overlapping transcript

chr8_-_18666295 0.532 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr18_+_47088400 0.522 NM_006033
LIPG
lipase, endothelial
chr1_+_220863627 0.520 NM_024709
C1orf115
chromosome 1 open reading frame 115
chr19_-_53606603 0.519 NM_001102603
NM_033288
NM_198893
ZNF160


zinc finger protein 160


chr6_-_35656677 0.463 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chr14_+_70078309 0.461 NM_014734
KIAA0247
KIAA0247
chr1_+_25870043 0.431 NM_015627
LDLRAP1
low density lipoprotein receptor adaptor protein 1
chr7_-_139477437 0.426 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr1_-_182361311 0.425 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr5_+_153570270 0.422 NM_198321
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr22_-_20307511 0.417 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr4_-_2263706 0.406 NM_006454
MXD4
MAX dimerization protein 4
chr3_+_9975513 0.405 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr11_+_94822937 0.403 NM_015036
ENDOD1
endonuclease domain containing 1
chr21_-_18985224 0.402 NM_001130914
NM_006806
BTG3

BTG family, member 3

chr4_+_2845552 0.401 NM_001119
NM_014189
NM_014190
NM_176801
ADD1



adducin 1 (alpha)



chr3_-_88199015 0.400 NM_001195308
CGGBP1
CGG triplet repeat binding protein 1
chr1_+_21766559 0.381 NM_032264
NBPF3
neuroblastoma breakpoint family, member 3
chr3_+_108308336 0.378 NM_014648
DZIP3
DAZ interacting protein 3, zinc finger
chr2_-_97405799 0.378 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr18_-_3011944 0.373 NM_014646
LPIN2
lipin 2
chr10_-_101945686 0.369 NM_006459
ERLIN1
ER lipid raft associated 1
chr1_+_173684061 0.367 NM_014458
KLHL20
kelch-like 20 (Drosophila)
chr14_-_20020271 0.363 NM_001145442
POTEG
POTEM
POTE ankyrin domain family, member G
POTE ankyrin domain family, member M
chr15_+_67358194 0.359 NM_005902
SMAD3
SMAD family member 3
chr5_-_137071703 0.358 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr10_-_101945787 0.357 NM_001100626
ERLIN1
ER lipid raft associated 1
chr4_-_42658883 0.347 NM_001105529
NM_006095
ATP8A1

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

chr5_-_59189620 0.343 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_107168336 0.342 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr22_+_18893735 0.341 NM_005675
DGCR6
DiGeorge syndrome critical region gene 6
chr5_+_141346401 0.338 NM_001201365
NM_183399
RNF14

ring finger protein 14

chr9_+_125703111 0.334 NM_012197
RABGAP1
RAB GTPase activating protein 1
chr20_-_5093482 0.326 NM_001009923
NM_001009924
NM_001009925
NM_014145
C20orf30



chromosome 20 open reading frame 30



chr14_+_55738020 0.325 NM_017943
FBXO34
F-box protein 34
chr12_+_54955226 0.324 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr3_-_51533996 0.321 NM_001171904
NM_014703
VPRBP

Vpr (HIV-1) binding protein

chr21_+_45345278 0.317 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr7_+_90893735 0.311 NM_003505
FZD1
frizzled family receptor 1
chr20_+_43104513 0.310 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr14_-_23388380 0.305 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr15_+_81071708 0.305 NM_018689
KIAA1199
KIAA1199
chrX_+_108780235 0.304 NM_001242618
NXT2
nuclear transport factor 2-like export factor 2
chr6_+_52285804 0.300 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr1_+_117910052 0.299 NM_006699
MAN1A2
mannosidase, alpha, class 1A, member 2
chrX_+_73641084 0.290 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr11_+_66886735 0.286 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chrX_+_108780058 0.283 NM_001242617
NXT2
nuclear transport factor 2-like export factor 2
chr2_+_166428845 0.281 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_+_179712297 0.278 NM_173509
FAM163A
family with sequence similarity 163, member A
chr1_-_182360400 0.276 NM_001033056
GLUL
glutamate-ammonia ligase
chr2_-_231090443 0.273 NM_001185015
SP110
SP110 nuclear body protein
chr19_+_4969123 0.272 NM_015015
KDM4B
lysine (K)-specific demethylase 4B
chr13_+_111839172 0.270 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr9_+_115913227 0.267 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr2_-_202316227 0.265 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr6_+_52284948 0.262 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr2_+_202004997 0.257 NM_001202515
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_+_183873253 0.247 NM_004423
DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr3_-_13114547 0.241 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr4_+_175839508 0.241 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr9_+_96338671 0.232 NM_005392
PHF2
PHD finger protein 2
chr5_+_141348692 0.231 NM_183401
RNF14
ring finger protein 14
chr15_+_67430358 0.227 NM_001145103
SMAD3
SMAD family member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.65 4.69e-04 GO:0031323 regulation of cellular metabolic process
1.65 5.01e-04 GO:0080090 regulation of primary metabolic process
1.80 6.85e-04 GO:0010468 regulation of gene expression
1.58 1.41e-03 GO:0019222 regulation of metabolic process
1.64 1.57e-03 GO:0060255 regulation of macromolecule metabolic process
1.77 2.15e-03 GO:0010556 regulation of macromolecule biosynthetic process
2.09 2.56e-03 GO:0009966 regulation of signal transduction
1.77 3.68e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.70 5.05e-03 GO:0009889 regulation of biosynthetic process
1.70 6.77e-03 GO:0031326 regulation of cellular biosynthetic process
1.75 1.95e-02 GO:0006355 regulation of transcription, DNA-dependent
1.71 3.03e-02 GO:0051252 regulation of RNA metabolic process
1.63 3.87e-02 GO:0048518 positive regulation of biological process
1.86 4.10e-02 GO:0023051 regulation of signaling
2.37 4.11e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.62 4.83e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.04 4.90e-02 GO:0010604 positive regulation of macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 3.35e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.32 3.37e-03 GO:0005515 protein binding