Motif ID: ACCCUGU

Z-value: 0.625


Mature miRNA associated with seed ACCCUGU:

NamemiRBase Accession
hsa-miR-10a MIMAT0000253
hsa-miR-10b MIMAT0000254



Activity profile for motif ACCCUGU.

activity profile for motif ACCCUGU


Sorted Z-values histogram for motif ACCCUGU

Sorted Z-values for motif ACCCUGU



Network of associatons between targets according to the STRING database.



First level regulatory network of ACCCUGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_11538486 9.669 NM_001100829
TMEM170B
transmembrane protein 170B
chr6_-_91006460 8.551 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr6_-_91006580 8.218 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr15_-_61521478 5.907 NM_134261
RORA
RAR-related orphan receptor A
chr9_-_23821842 5.707 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_44924946 5.528 NM_033224
PURB
purine-rich element binding protein B
chr2_-_206950895 5.373 NM_017759
INO80D
INO80 complex subunit D
chr12_+_69864065 5.312 NM_001042555
NM_006654
FRS2

fibroblast growth factor receptor substrate 2

chr16_+_50186809 5.261 NM_001040284
NM_001040285
PAPD5

PAP associated domain containing 5

chr15_-_60884615 5.249 NM_134262
RORA
RAR-related orphan receptor A
chr2_+_10183630 5.236 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr9_-_23826062 5.017 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr19_+_10541334 4.896 NM_001111308
PDE4A
phosphodiesterase 4A, cAMP-specific
chr9_-_23821477 4.761 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr17_+_18218569 4.309 NM_144775
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr5_-_160975124 3.879 NM_000813
NM_021911
GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2

chr3_+_14989076 3.641 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr15_-_60919642 3.614 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr11_-_27722446 3.521 NM_001143812
BDNF
brain-derived neurotrophic factor
chr16_-_70719854 3.519 NM_138383
MTSS1L
metastasis suppressor 1-like
chr11_-_27722599 3.440 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr11_-_27723061 3.414 NM_170733
BDNF
brain-derived neurotrophic factor
chr11_-_27721975 3.332 NM_001143813
NM_001143814
NM_001709
BDNF


brain-derived neurotrophic factor


chr8_-_66753968 3.230 NM_001242318
PDE7A
phosphodiesterase 7A
chr11_-_18655962 3.212 NM_194285
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr19_+_10531128 3.027 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr8_-_41754244 2.959 NM_001142446
ANK1
ankyrin 1, erythrocytic
chr16_+_69599868 2.951 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr12_-_114846191 2.914 NM_000192
NM_080717
TBX5

T-box 5

chr3_-_9994057 2.902 NM_207351
PRRT3
proline-rich transmembrane protein 3
chr7_+_20370724 2.785 NM_002214
ITGB8
integrin, beta 8
chr10_-_30348433 2.761 NM_020848
KIAA1462
KIAA1462
chr11_-_27743604 2.724 NM_170731
BDNF
brain-derived neurotrophic factor
chr17_-_46651809 2.685 NM_002146
HOXB3
homeobox B3
chr11_-_27681195 2.640 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr17_-_7518124 2.611 NM_004860
FXR2
fragile X mental retardation, autosomal homolog 2
chr11_-_27742224 2.592 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr11_-_27741192 2.568 NM_001143807
BDNF
brain-derived neurotrophic factor
chr12_-_114843888 2.528 NM_181486
TBX5
T-box 5
chr2_+_64681270 2.522 NM_014181
LGALSL
lectin, galactoside-binding-like
chr11_-_27721179 2.508 NM_170734
BDNF
brain-derived neurotrophic factor
chr12_+_4918341 2.486 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr7_-_27159213 2.470 NM_030661
HOXA3
homeobox A3
chr12_-_30848805 2.456 NM_006390
IPO8
importin 8
chr18_+_9136742 2.397 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr3_-_187463474 2.226 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr12_-_105322056 2.199 NM_032148
SLC41A2
solute carrier family 41, member 2
chr2_+_111878450 2.177 NM_001204106
NM_001204107
NM_001204108
NM_001204109
NM_001204110
NM_001204111
NM_001204112
NM_001204113
NM_006538
NM_138621
NM_138622
NM_138623
NM_138624
NM_138625
NM_138626
NM_138627
NM_207002
NM_207003
BCL2L11

















BCL2-like 11 (apoptosis facilitator)

















chr12_-_30830143 2.140 NM_001190995
IPO8
importin 8
chr9_+_112403067 2.139 NM_001037293
PALM2
paralemmin 2
chr15_+_42066631 2.137 NM_001128608
NM_014994
MAPKBP1

mitogen-activated protein kinase binding protein 1

chr7_-_138665853 2.098 NM_001164665
NM_020910
KIAA1549

KIAA1549

chrX_+_49687212 2.020 NM_001127898
NM_001127899
CLCN5

chloride channel 5

chr7_-_72936592 2.000 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr19_+_10543110 1.933 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr7_-_92463211 1.895 NM_001259
CDK6
cyclin-dependent kinase 6
chr7_-_27166638 1.894 NM_153631
HOXA3
homeobox A3
chr8_-_66701175 1.887 NM_002603
PDE7A
phosphodiesterase 7A
chr2_-_69870976 1.789 NM_014911
AAK1
AP2 associated kinase 1
chr2_+_10184371 1.769 NM_001177718
KLF11
Kruppel-like factor 11
chr2_+_97426571 1.740 NM_020184
CNNM4
cyclin M4
chr3_-_187454247 1.694 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr1_+_28052467 1.663 NM_001143912
NM_001143913
NM_001143914
NM_001143915
NM_152660
FAM76A




family with sequence similarity 76, member A




chr8_-_41655139 1.637 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr22_+_46546498 1.562 NM_001001928
NM_005036
PPARA

peroxisome proliferator-activated receptor alpha

chr9_+_100263818 1.522 NM_003275
TMOD1
tropomodulin 1
chr1_-_85155885 1.517 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr10_-_62149487 1.469 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_+_107811272 1.468 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr9_+_100263461 1.404 NM_001166116
TMOD1
tropomodulin 1
chr2_-_37193609 1.396 NM_003162
STRN
striatin, calmodulin binding protein
chr1_-_217311095 1.385 NM_001134285
ESRRG
estrogen-related receptor gamma
chr8_-_25902639 1.385 NM_022659
EBF2
early B-cell factor 2
chr3_+_48956272 1.373 NM_006321
ARIH2
ariadne homolog 2 (Drosophila)
chr10_+_103113807 1.372 NM_003939
NM_033637
BTRC

beta-transducin repeat containing

chr7_-_44365019 1.359 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr4_-_66535652 1.302 NM_004439
NM_182472
EPHA5

EPH receptor A5

chr19_+_10563581 1.271 NM_006202
PDE4A
phosphodiesterase 4A, cAMP-specific
chr8_+_22857063 1.271 NM_015178
RHOBTB2
Rho-related BTB domain containing 2
chr15_-_56285732 1.220 NM_006154
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr10_-_61900659 1.205 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_-_92465929 1.199 NM_001145306
CDK6
cyclin-dependent kinase 6
chr17_+_36861857 1.192 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr19_+_13105970 1.145 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_-_93204035 1.118 NM_001164737
NM_001742
CALCR

calcitonin receptor

chr14_+_99947732 1.101 NM_001099402
CCNK
cyclin K
chr2_-_128100673 1.097 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr2_+_176981491 1.041 NM_002148
HOXD10
homeobox D10
chr3_-_187452669 1.024 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr3_+_178866124 0.993 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr8_-_16050220 0.960 NM_002445
NM_138715
NM_138716
MSR1


macrophage scavenger receptor 1


chr9_-_93405066 0.910 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr1_+_204797774 0.902 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr9_+_129567260 0.879 NM_001135776
NM_014007
ZBTB43

zinc finger and BTB domain containing 43

chr12_-_125052009 0.866 NM_001077261
NM_001206654
NM_006312
NCOR2


nuclear receptor corepressor 2


chr8_-_41522724 0.855 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr1_+_26758772 0.831 NM_001243564
NM_001243565
NM_024887
NM_205861
DHDDS



dehydrodolichyl diphosphate synthase



chr10_-_62332666 0.830 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_-_20141593 0.811 NM_019062
RNF186
ring finger protein 186
chr1_-_38325224 0.808 NM_005955
MTF1
metal-regulatory transcription factor 1
chr18_+_19749403 0.780 NM_005257
GATA6
GATA binding protein 6
chr2_+_121103670 0.743 NM_002193
INHBB
inhibin, beta B
chr14_+_33408458 0.714 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr1_-_9970265 0.699 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr22_+_45559725 0.685 NM_007172
NUP50
nucleoporin 50kDa
chr1_-_216896640 0.650 NM_001243515
NM_001243518
NM_001243519
NM_001438
ESRRG



estrogen-related receptor gamma



chr8_+_22853360 0.641 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr12_+_5019048 0.636 NM_000217
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr21_+_17102370 0.620 NM_013396
USP25
ubiquitin specific peptidase 25
chr6_-_11044354 0.606 NM_017770
ELOVL2
ELOVL fatty acid elongase 2
chr3_-_142166782 0.589 NM_001042604
NM_019001
XRN1

5'-3' exoribonuclease 1

chrX_-_41782230 0.586 NM_001126054
NM_001126055
NM_003688
CASK


calcium/calmodulin-dependent serine protein kinase (MAGUK family)


chr17_-_4167028 0.579 NM_016376
NM_020740
ANKFY1

ankyrin repeat and FYVE domain containing 1

chr1_+_57110745 0.568 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr2_+_166428845 0.520 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chrX_-_130423387 0.518 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr18_-_33647336 0.498 NM_018170
RPRD1A
regulation of nuclear pre-mRNA domain containing 1A
chr10_-_62493282 0.493 NM_001204403
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_-_93189121 0.483 NM_001164738
CALCR
calcitonin receptor
chr8_+_1449531 0.475 NM_004745
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr2_-_2334887 0.465 NM_015025
MYT1L
myelin transcription factor 1-like
chr8_+_22844918 0.426 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr1_-_217262946 0.386 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr17_-_56084656 0.379 NM_001078166
NM_006924
SRSF1

serine/arginine-rich splicing factor 1

chr22_+_40573879 0.375 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr11_+_66024746 0.356 NM_001134775
KLC2
kinesin light chain 2
chr1_+_199996729 0.294 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr4_+_3076236 0.222 NM_002111
HTT
huntingtin
chr21_-_32931289 0.197 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr21_+_45285101 0.178 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr21_+_45345278 0.167 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr18_+_9137560 0.149 NM_001204056
ANKRD12
ankyrin repeat domain 12
chr13_-_27745952 0.137 NM_182488
USP12
ubiquitin specific peptidase 12
chrX_-_73834460 0.132 NM_016120
NM_183353
RLIM

ring finger protein, LIM domain interacting

chr1_+_204913353 0.094 NM_001160331
NFASC
neurofascin
chr15_+_85923739 0.082 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr13_-_33859835 0.073 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr22_-_19166296 0.048 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_+_40440664 0.047 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr4_+_154074269 0.040 NM_001130067
TRIM2
tripartite motif containing 2
chr2_-_20425166 0.020 NM_001006946
SDC1
syndecan 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.62 2.12e-04 GO:0065007 biological regulation
1.69 3.52e-04 GO:0050794 regulation of cellular process
1.65 3.93e-04 GO:0050789 regulation of biological process
2.41 6.41e-04 GO:0031326 regulation of cellular biosynthetic process
2.39 8.18e-04 GO:0009889 regulation of biosynthetic process
2.44 8.23e-04 GO:0010468 regulation of gene expression
2.57 1.20e-03 GO:0006355 regulation of transcription, DNA-dependent
2.17 1.21e-03 GO:0060255 regulation of macromolecule metabolic process
2.43 1.45e-03 GO:0010556 regulation of macromolecule biosynthetic process
2.48 2.48e-03 GO:0051252 regulation of RNA metabolic process
2.41 2.74e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
5.14 4.73e-03 GO:0032583 regulation of gene-specific transcription
2.03 5.62e-03 GO:0031323 regulation of cellular metabolic process
5.53 6.57e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
16.29 6.97e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.95 7.13e-03 GO:0019222 regulation of metabolic process
2.00 1.13e-02 GO:0080090 regulation of primary metabolic process
1.95 1.46e-02 GO:0023052 signaling
185.58 1.48e-02 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter
2.18 1.80e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.12 3.12e-02 GO:0051171 regulation of nitrogen compound metabolic process
3.17 3.33e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
123.73 4.44e-02 GO:0021563 glossopharyngeal nerve development
123.73 4.44e-02 GO:0021615 glossopharyngeal nerve morphogenesis

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.61 2.26e-04 GO:0001071 nucleic acid binding transcription factor activity
3.61 2.26e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
18.20 9.85e-04 GO:0003707 steroid hormone receptor activity
17.19 1.31e-03 GO:0004879 ligand-dependent nuclear receptor activity
3.32 1.35e-03 GO:0030528 transcription regulator activity
3.76 4.77e-03 GO:0043565 sequence-specific DNA binding
1.26 1.60e-02 GO:0005488 binding
1.45 4.54e-02 GO:0005515 protein binding
2.06 4.78e-02 GO:0003677 DNA binding