Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.217


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX3chr20_-_39928708-0.236.6e-04Click!
IRX4chr5_-_1882764-0.202.4e-03Click!
SIX2chr2_-_45236521-0.171.4e-02Click!
ZHX2chr8_+_123793988,
chr8_+_123794043
-0.144.4e-02Click!
SIX5chr19_-_46272496-0.127.0e-02Click!
ADNPchr20_-_495474510.101.2e-01Click!
IRX5chr16_+_549651100.027.3e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_5136556 37.019 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5136589 33.584 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5136613 33.233 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_-_10942642 30.126 PDIA6
protein disulfide isomerase family A, member 6
chr5_+_115898218 21.633


chr12_-_102512277 20.577 NM_024057
NUP37
nucleoporin 37kDa
chr8_-_86290333 17.994 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr14_-_55650348 17.271 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr3_-_141747434 16.114 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr13_+_53035227 14.944 CKAP2
cytoskeleton associated protein 2
chr19_+_13134782 14.356 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr18_+_33234532 14.009 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr10_+_5005685 13.699 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_+_167298280 13.582 NM_001198783
POU2F1
POU class 2 homeobox 1
chr4_-_72649734 13.171 NM_000583
GC
group-specific component (vitamin D binding protein)
chr11_-_118900078 11.907 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr4_+_146031528 11.854 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr6_+_21593963 11.688 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr20_-_34243118 11.633 RBM12
RNA binding motif protein 12
chr9_-_14086901 11.325 NFIB
nuclear factor I/B
chr12_+_20963637 10.639 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr15_-_56209305 10.452 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr6_+_64356430 10.390 NM_015153
PHF3
PHD finger protein 3
chr10_+_5005601 10.341 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chrX_+_118714297 10.209 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A
chr3_-_57234279 9.627 NM_003865
HESX1
HESX homeobox 1
chr7_-_25268057 9.485 NM_022150
NPVF
neuropeptide VF precursor
chr10_-_5045967 9.466 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr16_+_56817367 9.251 NM_001242796
NUP93
nucleoporin 93kDa
chr2_+_204055404 9.046 RPL12
ribosomal protein L12
chr7_-_26232148 8.449 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr11_+_114167197 8.402 NNMT
nicotinamide N-methyltransferase
chr12_+_50869531 8.208 LARP4
La ribonucleoprotein domain family, member 4
chr11_+_114167168 8.077 NNMT
nicotinamide N-methyltransferase
chr6_+_34206567 7.988 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_+_89267589 7.969 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr11_+_114166534 7.633 NM_006169
NNMT
nicotinamide N-methyltransferase
chr1_+_68150858 7.502 NM_001199741
NM_001199742
NM_001924
GADD45A


growth arrest and DNA-damage-inducible, alpha


chr3_-_113897849 7.418 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr12_+_54410893 7.396 HOXC5
HOXC6
homeobox C5
homeobox C6
chr4_+_140587086 7.314 MGST2
microsomal glutathione S-transferase 2
chr1_+_74701070 7.289 NM_015978
TNNI3K
TNNI3 interacting kinase
chr10_-_75006963 7.279 NM_015190
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr6_-_86351156 7.241 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr10_+_5005453 7.220 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr11_+_101983170 7.220 NM_001195045
YAP1
Yes-associated protein 1
chr6_+_34204928 7.108 HMGA1
high mobility group AT-hook 1
chr1_+_167298382 7.023 POU2F1
POU class 2 homeobox 1
chr4_+_74269971 6.928 NM_000477
ALB
albumin
chr8_-_86253863 6.924 NM_001164830
CA1
carbonic anhydrase I
chr5_-_98262217 6.894 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr5_+_102465256 6.831 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chrX_+_99839789 6.817 NM_022144
TNMD
tenomodulin
chr9_+_97521930 6.735 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr1_+_236557643 6.662 NM_145861
EDARADD
EDAR-associated death domain
chr4_-_7069801 6.580 GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chrX_+_70765479 6.518 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr14_+_102276279 6.480 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chrX_+_123234462 6.459 STAG2
stromal antigen 2
chr6_+_64286348 6.368 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_-_100046262 6.347 REV1
REV1 homolog (S. cerevisiae)
chr1_+_64088886 6.342 NM_001172818
PGM1
phosphoglucomutase 1
chr17_-_64225496 6.235 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr22_-_36236421 6.187 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr8_-_72268720 6.043 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr4_-_70518964 5.934 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr2_+_234580504 5.905 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr6_+_49467670 5.883 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr17_-_46622274 5.818 NM_002145
HOXB2
homeobox B2
chr8_+_9953061 5.715 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chr17_-_15554809 5.625 TRIM16
tripartite motif containing 16
chr14_-_69354900 5.599 ACTN1
actinin, alpha 1
chr2_+_234637772 5.591 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr2_-_190927321 5.566 NM_005259
MSTN
myostatin
chr13_+_53216564 5.514 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr6_-_138820580 5.475


chr9_-_104198045 5.447 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr9_-_86584079 5.442 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr7_+_115863004 5.362 NM_152829
TES
testis derived transcript (3 LIM domains)
chr19_-_40331153 5.285 FBL
fibrillarin
chr3_-_25683825 5.229 TOP2B
topoisomerase (DNA) II beta 180kDa
chr2_+_171784947 5.209 NM_001201428
NM_015530
GORASP2

golgi reassembly stacking protein 2, 55kDa

chr7_-_27205148 5.196 NM_152739
HOXA9
homeobox A9
chr6_+_136172802 5.175 NM_018945
PDE7B
phosphodiesterase 7B
chr14_+_58711457 5.159 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr11_-_27742224 5.098 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr14_+_58711599 5.088 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr3_+_63884074 5.069 NM_001177387
ATXN7
ataxin 7
chr7_-_72936538 4.990 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr5_+_138211084 4.863 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr20_+_30326903 4.857 NM_012112
TPX2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr2_+_172821874 4.857 HAT1
histone acetyltransferase 1
chr14_+_58711555 4.854 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr11_+_87032428 4.797 TMEM135
transmembrane protein 135
chr2_-_74382352 4.778


chr2_-_136634002 4.765 NM_005915
MCM6
minichromosome maintenance complex component 6
chr15_+_57511616 4.711 NM_207040
TCF12
transcription factor 12
chr3_+_136649316 4.690 NM_001190796
NCK1
NCK adaptor protein 1
chr14_+_67831484 4.654 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_109204745 4.651 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_158656487 4.625 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr8_-_82395401 4.613 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr14_+_74035762 4.559 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr13_-_103719195 4.535 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr7_-_27205123 4.527 HOXA9
homeobox A9
chr4_+_1902352 4.519 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr4_-_74088773 4.465 ANKRD17
ankyrin repeat domain 17
chr17_-_38821286 4.457 NM_152349
KRT222
keratin 222
chr2_-_133429069 4.438 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr5_+_65372744 4.429 ERBB2IP
erbb2 interacting protein
chr5_+_44808967 4.428 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr15_+_49715374 4.390 NM_002009
FGF7
fibroblast growth factor 7
chr3_+_151985828 4.365 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr8_+_66582107 4.349 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr12_-_54653369 4.340 NM_001127321
CBX5
chromobox homolog 5
chr17_-_39191100 4.327 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr12_-_102874340 4.289 IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_+_162930230 4.284 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr10_+_75673346 4.277 PLAU
plasminogen activator, urokinase
chr11_+_113775517 4.276 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr2_+_228356287 4.262 AGFG1
ArfGAP with FG repeats 1
chr21_-_33074101 4.241 SCAF4
SR-related CTD-associated factor 4
chr12_-_14132920 4.238 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr17_-_49124128 4.234 NM_001251971
SPAG9
sperm associated antigen 9
chr2_-_61764661 4.194 XPO1
exportin 1 (CRM1 homolog, yeast)
chr2_+_109204904 4.139 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr11_+_99426872 4.114 NM_175566
CNTN5
contactin 5
chr5_+_6746100 4.086 NM_001171806
PAPD7
PAP associated domain containing 7
chr15_+_94899163 4.073 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr12_+_16064105 4.037 NM_015954
DERA
deoxyribose-phosphate aldolase (putative)
chr5_-_111091947 4.032 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr5_-_179044835 4.023 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr6_-_36515245 4.001 NM_007271
STK38
serine/threonine kinase 38
chr20_+_32150139 3.987 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr12_-_91398757 3.981 NM_004950
EPYC
epiphycan
chr3_-_196911001 3.965 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr9_+_135854097 3.964 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr5_-_140895407 3.962 DIAPH1
diaphanous homolog 1 (Drosophila)
chr6_+_167525294 3.948 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr15_+_52201590 3.946 TMOD3
tropomodulin 3 (ubiquitous)
chr18_-_51690988 3.924 MBD2
methyl-CpG binding domain protein 2
chr3_+_149192367 3.921 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr21_-_36421586 3.918 NM_001754
RUNX1
runt-related transcription factor 1
chr2_+_234545099 3.903 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr16_+_56815703 3.896 NM_001242795
NUP93
nucleoporin 93kDa
chr2_+_216986817 3.877 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chrX_-_55057408 3.851 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr4_-_7069755 3.840 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr10_+_94352960 3.822 KIF11
kinesin family member 11
chr14_+_102276125 3.804 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chrX_-_18690187 3.755 NM_000330
RS1
retinoschisin 1
chr1_+_78470593 3.735 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_-_93257950 3.730 NM_005665
EVI5
ecotropic viral integration site 5
chr14_-_23504353 3.650 NM_001144932
NM_002797
NM_001130725
PSMB5


proteasome (prosome, macropain) subunit, beta type, 5


chr12_-_54653317 3.625 NM_001127322
CBX5
chromobox homolog 5
chr22_-_37098620 3.569 NM_006078
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chr10_-_98325100 3.545 TM9SF3
transmembrane 9 superfamily member 3
chr3_-_27498244 3.536 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr1_-_159684274 3.528 NM_000567
CRP
C-reactive protein, pentraxin-related
chr6_-_155777036 3.526 NM_015718
NOX3
NADPH oxidase 3
chr2_-_200329810 3.518 NM_001172517
SATB2
SATB homeobox 2
chr1_+_32661018 3.508 TXLNA
taxilin alpha
chr7_+_107110501 3.506 NM_005295
GPR22
G protein-coupled receptor 22
chr2_+_211458078 3.471 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr5_+_132432880 3.447 HSPA4
heat shock 70kDa protein 4
chr4_+_155484131 3.446 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr20_-_7921068 3.441 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_25874439 3.419 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr6_+_34204576 3.388 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr3_+_149192479 3.368 TM4SF4
transmembrane 4 L six family member 4
chr17_-_46682333 3.348 NM_018952
HOXB6
homeobox B6
chr4_-_111563278 3.343 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr17_-_79876024 3.337 SIRT7
sirtuin 7
chr3_-_194188967 3.335 NM_024524
ATP13A3
ATPase type 13A3
chr2_+_109223600 3.331 NM_001193482
LIMS1
LIM and senescent cell antigen-like domains 1
chr4_+_41614725 3.322 LIMCH1
LIM and calponin homology domains 1
chr1_+_168250277 3.318 NM_005149
TBX19
T-box 19
chr11_-_83393436 3.315 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr13_+_98605928 3.283 NM_002271
IPO5
importin 5
chr2_+_86333304 3.265 NM_017952
PTCD3
Pentatricopeptide repeat domain 3
chr17_-_48785016 3.265 NM_052855
ANKRD40
ankyrin repeat domain 40
chr9_+_36572844 3.225 NM_014791
MELK
maternal embryonic leucine zipper kinase
chr8_-_6420454 3.201 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr7_+_28452143 3.199 NM_182898
CREB5
cAMP responsive element binding protein 5
chr14_-_65409445 3.190 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_+_54292035 3.187 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr10_-_94257470 3.180 NM_001165946
IDE
insulin-degrading enzyme
chr5_-_95158465 3.173 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr9_+_79968344 3.171 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr22_-_36236264 3.162 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr6_+_155538096 3.148 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr7_+_80275634 3.143 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr15_+_66797632 3.132 ZWILCH
Zwilch, kinetochore associated, homolog (Drosophila)
chr6_-_75965845 3.127 TMEM30A
transmembrane protein 30A
chr2_-_192711923 3.125 NM_004657
SDPR
serum deprivation response
chr5_+_126859157 3.108 PRRC1
proline-rich coiled-coil 1
chr2_+_234627423 3.064 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr7_+_134212343 3.047 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr5_-_95158365 3.041 GLRX
glutaredoxin (thioltransferase)
chr17_+_28268622 3.018 NM_198529
EFCAB5
EF-hand calcium binding domain 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 2.87e-13 GO:0009987 cellular process
1.26 1.19e-10 GO:0065007 biological regulation
1.27 1.31e-09 GO:0050789 regulation of biological process
1.30 2.01e-09 GO:0044237 cellular metabolic process
1.66 1.21e-08 GO:0048513 organ development
1.96 2.29e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.42 2.55e-08 GO:0032502 developmental process
1.25 5.01e-08 GO:0008152 metabolic process
1.28 1.13e-07 GO:0050896 response to stimulus
1.45 1.22e-07 GO:0034641 cellular nitrogen compound metabolic process
1.55 1.98e-07 GO:0042221 response to chemical stimulus
1.44 2.06e-07 GO:0006807 nitrogen compound metabolic process
2.12 2.31e-07 GO:0010628 positive regulation of gene expression
1.53 3.44e-07 GO:0048519 negative regulation of biological process
2.16 4.16e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.27 4.34e-07 GO:0044238 primary metabolic process
2.04 4.36e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.41 5.56e-07 GO:0007275 multicellular organismal development
1.24 1.10e-06 GO:0050794 regulation of cellular process
1.94 1.42e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.54 1.76e-06 GO:0048523 negative regulation of cellular process
1.39 1.77e-06 GO:0080090 regulation of primary metabolic process
1.41 2.18e-06 GO:0060255 regulation of macromolecule metabolic process
1.42 2.52e-06 GO:0048856 anatomical structure development
1.91 3.44e-06 GO:0009891 positive regulation of biosynthetic process
1.29 4.60e-06 GO:0032501 multicellular organismal process
1.44 7.15e-06 GO:0048731 system development
1.93 1.06e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
2.01 1.06e-05 GO:0051254 positive regulation of RNA metabolic process
1.35 1.17e-05 GO:0019222 regulation of metabolic process
1.44 1.37e-05 GO:0048518 positive regulation of biological process
1.32 1.45e-05 GO:0044260 cellular macromolecule metabolic process
1.69 1.75e-05 GO:0009893 positive regulation of metabolic process
1.49 2.10e-05 GO:0090304 nucleic acid metabolic process
1.43 2.20e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.91 2.62e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.55 2.67e-05 GO:0010467 gene expression
1.36 2.82e-05 GO:0031323 regulation of cellular metabolic process
1.49 3.03e-05 GO:0065008 regulation of biological quality
1.70 3.14e-05 GO:0031325 positive regulation of cellular metabolic process
1.29 3.52e-05 GO:0043170 macromolecule metabolic process
1.70 4.54e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.45 4.61e-05 GO:0048522 positive regulation of cellular process
2.15 7.92e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.45 1.51e-04 GO:0051252 regulation of RNA metabolic process
1.42 1.71e-04 GO:0010468 regulation of gene expression
1.43 1.81e-04 GO:0010556 regulation of macromolecule biosynthetic process
2.38 2.01e-04 GO:0001501 skeletal system development
1.40 2.31e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.78 2.35e-04 GO:0006351 transcription, DNA-dependent
1.89 2.38e-04 GO:0009790 embryo development
1.53 2.55e-04 GO:0009059 macromolecule biosynthetic process
1.43 2.59e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.52 2.61e-04 GO:0016070 RNA metabolic process
1.94 4.31e-04 GO:0009887 organ morphogenesis
2.13 4.45e-04 GO:0032583 regulation of gene-specific transcription
1.45 4.79e-04 GO:0006355 regulation of transcription, DNA-dependent
1.71 4.85e-04 GO:0032774 RNA biosynthetic process
1.39 5.03e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 6.04e-04 GO:0034645 cellular macromolecule biosynthetic process
1.39 7.80e-04 GO:0031326 regulation of cellular biosynthetic process
2.07 1.07e-03 GO:0051094 positive regulation of developmental process
1.38 1.17e-03 GO:0009889 regulation of biosynthetic process
1.32 1.21e-03 GO:0071840 cellular component organization or biogenesis
9.12 1.40e-03 GO:0060416 response to growth hormone stimulus
2.23 1.83e-03 GO:0045597 positive regulation of cell differentiation
1.68 2.47e-03 GO:0070887 cellular response to chemical stimulus
2.65 2.59e-03 GO:0048732 gland development
1.38 2.60e-03 GO:0009058 biosynthetic process
1.32 2.73e-03 GO:0016043 cellular component organization
1.66 2.97e-03 GO:0009892 negative regulation of metabolic process
1.39 3.07e-03 GO:0006950 response to stress
2.14 3.26e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.27 3.33e-03 GO:0051716 cellular response to stimulus
1.38 4.15e-03 GO:0044249 cellular biosynthetic process
1.50 5.35e-03 GO:0009653 anatomical structure morphogenesis
1.69 5.99e-03 GO:0009888 tissue development
4.91 7.87e-03 GO:0030193 regulation of blood coagulation
1.67 7.93e-03 GO:0042592 homeostatic process
1.65 9.90e-03 GO:0031324 negative regulation of cellular metabolic process
1.63 1.52e-02 GO:0050793 regulation of developmental process
3.44 1.75e-02 GO:0048706 embryonic skeletal system development
4.56 1.87e-02 GO:0045639 positive regulation of myeloid cell differentiation
4.56 1.87e-02 GO:0050818 regulation of coagulation
1.70 2.05e-02 GO:2000026 regulation of multicellular organismal development
1.72 2.12e-02 GO:0006082 organic acid metabolic process
2.76 2.30e-02 GO:0006805 xenobiotic metabolic process
2.76 2.30e-02 GO:0071466 cellular response to xenobiotic stimulus
2.38 2.34e-02 GO:0043193 positive regulation of gene-specific transcription
2.21 2.42e-02 GO:0007346 regulation of mitotic cell cycle
2.02 2.48e-02 GO:0043009 chordate embryonic development
2.74 2.61e-02 GO:0009410 response to xenobiotic stimulus
1.51 2.66e-02 GO:0051239 regulation of multicellular organismal process
1.61 2.72e-02 GO:0010605 negative regulation of macromolecule metabolic process
2.19 2.89e-02 GO:0048545 response to steroid hormone stimulus
3.31 2.97e-02 GO:0045637 regulation of myeloid cell differentiation
2.00 3.33e-02 GO:0009792 embryo development ending in birth or egg hatching
1.50 3.94e-02 GO:0010033 response to organic substance
2.06 4.98e-02 GO:0032787 monocarboxylic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 1.71e-07 GO:0043233 organelle lumen
1.49 6.87e-07 GO:0031974 membrane-enclosed lumen
1.49 2.36e-06 GO:0044428 nuclear part
1.54 2.43e-06 GO:0031981 nuclear lumen
1.75 3.43e-06 GO:0044421 extracellular region part
1.47 3.70e-06 GO:0070013 intracellular organelle lumen
1.86 4.30e-06 GO:0005615 extracellular space
1.59 6.64e-05 GO:0005654 nucleoplasm
1.10 4.92e-04 GO:0044424 intracellular part
1.21 6.53e-04 GO:0005634 nucleus
1.74 7.61e-04 GO:0044451 nucleoplasm part
1.12 1.74e-03 GO:0043226 organelle
1.12 2.36e-03 GO:0043229 intracellular organelle
1.14 2.69e-03 GO:0005737 cytoplasm
1.13 2.96e-03 GO:0043227 membrane-bounded organelle
1.13 3.36e-03 GO:0043231 intracellular membrane-bounded organelle
2.23 3.43e-03 GO:0005667 transcription factor complex
1.36 6.78e-03 GO:0005576 extracellular region
1.09 1.01e-02 GO:0005622 intracellular
1.25 1.31e-02 GO:0032991 macromolecular complex
1.26 3.89e-02 GO:0043234 protein complex
3.74 4.59e-02 GO:0031093 platelet alpha granule lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.30 5.80e-14 GO:0005515 protein binding
1.14 8.39e-10 GO:0005488 binding
2.01 7.30e-07 GO:0043565 sequence-specific DNA binding
1.75 9.67e-06 GO:0001071 nucleic acid binding transcription factor activity
1.75 9.67e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.66 2.23e-04 GO:0030528 transcription regulator activity
1.64 4.50e-04 GO:0005102 receptor binding
5.70 2.64e-03 GO:0015020 glucuronosyltransferase activity
1.28 6.38e-03 GO:0003676 nucleic acid binding
2.29 1.56e-02 GO:0000975 regulatory region DNA binding
2.29 1.56e-02 GO:0001067 regulatory region nucleic acid binding
2.29 1.56e-02 GO:0044212 transcription regulatory region DNA binding
2.30 1.94e-02 GO:0010843 promoter binding
1.62 1.97e-02 GO:0019899 enzyme binding
1.32 2.63e-02 GO:0003677 DNA binding
1.89 2.93e-02 GO:0003712 transcription cofactor activity
1.88 3.13e-02 GO:0000988 protein binding transcription factor activity
1.88 3.13e-02 GO:0000989 transcription factor binding transcription factor activity
2.01 3.23e-02 GO:0008134 transcription factor binding
1.56 4.78e-02 GO:0003723 RNA binding