Motif ID: ATF4.p2

Z-value: 2.316


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_399165630.543.1e-18Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_123380608 91.173


chr5_-_133561745 70.025 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_+_16187306 69.868 TPM4
tropomyosin 4
chr8_-_17104266 68.307 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr6_+_47445440 62.788 NM_012120
CD2AP
CD2-associated protein
chr11_+_4116059 61.361 RRM1
ribonucleotide reductase M1
chr22_+_24236579 60.840 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr22_+_24236575 60.029


chr22_+_24236569 59.882 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr19_+_16187266 59.790 TPM4
tropomyosin 4
chr19_-_55918980 57.148 UBE2S
ubiquitin-conjugating enzyme E2S
chr22_+_24236586 57.041 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr22_+_24236556 54.700 NM_002415
MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr1_+_26496382 54.658 NM_015871
ZNF593
zinc finger protein 593
chr19_+_16187315 52.173 TPM4
tropomyosin 4
chr8_+_26149004 50.614 NM_002717
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr8_+_26149043 49.522 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr11_+_4115923 48.082 NM_001033
RRM1
ribonucleotide reductase M1
chr22_+_24236595 46.073 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr5_-_133561551 45.987 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_-_47617008 44.738 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr8_-_17104103 44.223 CNOT7
CCR4-NOT transcription complex, subunit 7
chr11_+_4116077 43.109 RRM1
ribonucleotide reductase M1
chr2_-_32236104 42.375 MEMO1
mediator of cell motility 1
chr1_-_70671263 40.860 NM_017768
LRRC40
leucine rich repeat containing 40
chr3_+_38206968 40.799 NM_005109
OXSR1
oxidative-stress responsive 1
chr3_-_49066760 39.963 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr15_-_91537724 39.708 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr3_-_49066858 39.086 NM_000884
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr7_+_56019552 38.650 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr1_+_52082755 38.366 OSBPL9
oxysterol binding protein-like 9
chr6_-_31774579 37.749 LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_-_245025958 37.127 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr2_-_240964717 37.029 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr12_-_6862131 36.219 MLF2
myeloid leukemia factor 2
chr18_+_20513277 35.628 NM_002894
RBBP8
retinoblastoma binding protein 8
chr3_-_49066813 35.420 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr6_-_53213586 35.240 ELOVL5
ELOVL fatty acid elongase 5
chr4_-_122744978 34.562 NM_001237
CCNA2
cyclin A2
chr4_-_104119475 33.995 NM_001813
CENPE
centromere protein E, 312kDa
chr4_-_122744782 33.863 CCNA2
cyclin A2
chr11_+_102217947 33.742 NM_001166
BIRC2
baculoviral IAP repeat containing 2
chr8_+_26149080 33.539 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_+_140396463 33.253 NM_004546
NDUFB2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr2_+_113403433 33.249 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr19_+_50180408 33.118 NM_001207042
NM_001536
NM_198318
PRMT1


protein arginine methyltransferase 1


chr1_-_115124211 33.049 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr19_+_50180492 32.730 PRMT1
protein arginine methyltransferase 1
chr12_+_69979268 32.466 CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr15_-_23034307 32.442 NIPA2
non imprinted in Prader-Willi/Angelman syndrome 2
chr6_-_31774725 32.432 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_+_100273776 31.559 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr19_-_40337018 31.441 NM_001436
FBL
fibrillarin
chr7_+_107531585 30.961 NM_000108
DLD
dihydrolipoamide dehydrogenase
chr11_-_67188614 30.567 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr10_-_75006963 30.517 NM_015190
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr1_-_70671160 30.509 LRRC40
leucine rich repeat containing 40
chr14_+_105219466 30.091 NM_006427
NM_021709
SIVA1

SIVA1, apoptosis-inducing factor

chr19_-_40336944 29.885 FBL
fibrillarin
chr12_+_69979202 29.871 NM_006431
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr2_-_240964807 29.633 NM_004544
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr7_+_107531618 29.402 DLD
dihydrolipoamide dehydrogenase
chr7_+_107531616 29.121 DLD
dihydrolipoamide dehydrogenase
chr3_-_52312655 28.894 NM_025222
WDR82
WD repeat domain 82
chr11_-_61584451 28.795 NM_013402
FADS1
fatty acid desaturase 1
chr5_+_10353980 28.303


chr5_-_32174385 27.892 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr14_+_100705101 27.868 NM_003403
YY1
YY1 transcription factor
chr20_+_19915716 27.529 RIN2
Ras and Rab interactor 2
chr2_-_62115714 27.138 CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr7_+_26240830 27.027 NM_007276
CBX3
chromobox homolog 3
chr5_+_138211084 26.968 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr12_+_69979447 26.726 NM_001198842
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr22_+_39898365 26.533 SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr1_+_203830723 26.412 SNRPE
small nuclear ribonucleoprotein polypeptide E
chr2_-_62115726 26.363 CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr1_+_110527327 26.331 NM_001242673
NM_006621
AHCYL1

adenosylhomocysteinase-like 1

chr11_+_108535773 26.256 NM_004398
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr12_+_69004684 26.218 RAP1B
RAP1B, member of RAS oncogene family
chr17_+_33914278 25.873 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr9_-_95055913 25.711 IARS
isoleucyl-tRNA synthetase
chr19_+_16187047 25.653 NM_003290
TPM4
tropomyosin 4
chr5_-_32174397 25.510 NM_022130
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr5_-_32174355 25.454 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr19_-_40336997 25.067 FBL
fibrillarin
chr19_+_36036448 24.828 NM_001242597
NM_001242598
NM_032635
TMEM147


transmembrane protein 147


chr16_+_81040847 24.532 CENPN
centromere protein N
chr11_-_6633400 24.252 TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr1_+_203830732 24.249 NM_003094
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr21_-_44527603 24.127 U2AF1
U2 small nuclear RNA auxiliary factor 1
chr12_+_69004710 23.992 RAP1B
RAP1B, member of RAS oncogene family
chr1_+_44440623 23.812 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr14_+_55518398 23.687 MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr12_+_132629014 23.647 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr12_+_104359557 23.580 NM_003211
TDG
thymine-DNA glycosylase
chr9_-_95055966 23.475 NM_013417
IARS
isoleucyl-tRNA synthetase
chr11_+_18416111 23.300 LDHA
lactate dehydrogenase A
chr1_-_229644077 23.281 NM_018230
NUP133
nucleoporin 133kDa
chr18_+_57567191 23.119 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr1_+_44440595 23.056 NM_001039457
NM_004047
ATP6V0B

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

chr7_-_26240364 23.046 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_+_56552141 23.044 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr11_+_18416106 23.027 LDHA
lactate dehydrogenase A
chr5_+_177631533 22.584 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr3_+_170075521 22.527 SKIL
SKI-like oncogene
chr2_-_32235603 22.506 NM_001137602
NM_015955
MEMO1

mediator of cell motility 1

chr22_-_36925212 22.425 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr1_+_44440642 22.358 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr2_-_32235722 22.335 MEMO1
mediator of cell motility 1
chr14_+_55518313 22.313 NM_144578
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr19_+_572568 22.174 BSG
basigin (Ok blood group)
chr9_-_95055986 22.136 IARS
isoleucyl-tRNA synthetase
chr7_+_127228405 22.128 NM_001662
ARF5
ADP-ribosylation factor 5
chr1_-_16482426 22.087 NM_004431
EPHA2
EPH receptor A2
chr7_+_5632435 22.038 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr19_+_10362912 22.031 MRPL4
mitochondrial ribosomal protein L4
chr3_-_113465101 21.963 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_-_62115744 21.878 NM_006430
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr17_-_20946088 21.786 NM_015276
USP22
ubiquitin specific peptidase 22
chr20_-_60718440 21.597 NM_002792
PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr22_-_36925270 21.573 NM_003753
EIF3D
eukaryotic translation initiation factor 3, subunit D
chr11_-_3818971 21.550 NM_005387
NM_016320
NM_139131
NM_139132
NUP98



nucleoporin 98kDa



chr1_-_229643996 21.526 NUP133
nucleoporin 133kDa
chr16_-_46655303 21.464 NM_024745
SHCBP1
SHC SH2-domain binding protein 1
chr14_+_55518372 21.392 MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr5_-_32174327 21.362 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr22_+_39898248 21.307 NM_019008
SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr7_+_44646220 21.278 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_-_26240320 21.253 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_242255365 21.174 SEPT2
septin 2
chr7_-_105925329 21.146 NAMPT
nicotinamide phosphoribosyltransferase
chr11_+_95523608 21.145 NM_001243776
NM_001243777
NM_014679
CEP57


centrosomal protein 57kDa


chr7_-_26240366 21.110 NM_002137
NM_031243
HNRNPA2B1

heterogeneous nuclear ribonucleoprotein A2/B1

chr18_+_158586 21.064 USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr22_-_36925138 21.042 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr19_-_14529853 20.974 DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr14_-_103523619 20.968 NM_006035
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr2_-_62115641 20.879 CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr1_+_70671331 20.795 NM_001190987
NM_004768
SRSF11

serine/arginine-rich splicing factor 11

chr8_+_98788014 20.705 LAPTM4B
lysosomal protein transmembrane 4 beta
chr6_-_3157696 20.662 NM_001069
TUBB2A
tubulin, beta 2A class IIa
chr3_+_127317274 20.628 MCM2
minichromosome maintenance complex component 2
chr19_-_8070468 20.282 NM_001419
ELAVL1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
chr17_+_80674579 20.278 NM_024619
FN3KRP
fructosamine 3 kinase related protein
chr17_+_15902693 20.088 NM_017775
TTC19
tetratricopeptide repeat domain 19
chr3_+_38207247 20.074 OXSR1
oxidative-stress responsive 1
chr11_-_28129646 19.957 KIF18A
kinesin family member 18A
chr1_+_203830763 19.906 SNRPE
small nuclear ribonucleoprotein polypeptide E
chr19_+_10362886 19.880 MRPL4
mitochondrial ribosomal protein L4
chr2_-_10588451 19.866 NM_002539
ODC1
ornithine decarboxylase 1
chr19_-_14530129 19.785 DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr3_-_133380626 19.627 NM_007027
TOPBP1
topoisomerase (DNA) II binding protein 1
chr1_-_33283632 19.598 NM_003680
YARS
tyrosyl-tRNA synthetase
chr12_+_54378929 19.564 NM_017409
HOXC10
homeobox C10
chr5_-_133561805 19.454 NM_002715
PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chrX_+_153672490 19.441 FAM50A
family with sequence similarity 50, member A
chr17_-_56084611 19.433 SRSF1
serine/arginine-rich splicing factor 1
chr19_-_55919324 19.302 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S
chr22_+_38597938 19.301 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr3_-_156877882 19.296 CCNL1
cyclin L1
chr5_-_133304274 19.267 NM_020199
C5orf15
chromosome 5 open reading frame 15
chr1_-_31769599 19.227 NM_004814
SNRNP40
small nuclear ribonucleoprotein 40kDa (U5)
chr4_+_170541690 19.190 CLCN3
chloride channel 3
chr11_+_118230348 19.095 UBE4A
ubiquitination factor E4A
chr2_-_70520780 18.996 SNRPG
small nuclear ribonucleoprotein polypeptide G
chr18_+_158480 18.987 NM_001037334
NM_005151
USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr19_+_1941157 18.973 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr1_-_32110464 18.942 PEF1
penta-EF-hand domain containing 1
chr19_+_13263890 18.822 IER2
immediate early response 2
chr16_+_28722977 18.807 EIF3C
eukaryotic translation initiation factor 3, subunit C
chr19_+_36630999 18.769 CAPNS1
calpain, small subunit 1
chr16_-_46655262 18.715 SHCBP1
SHC SH2-domain binding protein 1
chr19_+_572575 18.680 BSG
basigin (Ok blood group)
chrX_+_153672449 18.624 NM_004699
FAM50A
family with sequence similarity 50, member A
chr11_-_6633428 18.508 NM_006284
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chrX_+_67718868 18.463 YIPF6
Yip1 domain family, member 6
chr19_+_572403 18.431 NM_001728
NM_198589
BSG

basigin (Ok blood group)

chr9_-_127952037 18.424 NM_001123355
NM_001123369
NM_002721
PPP6C


protein phosphatase 6, catalytic subunit


chr5_+_177631534 18.386 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr17_+_8152594 18.383 NM_012393
PFAS
phosphoribosylformylglycinamidine synthase
chr22_-_36925175 18.339 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr14_+_100705279 18.291 YY1
YY1 transcription factor
chr1_+_110527432 18.290 AHCYL1
adenosylhomocysteinase-like 1
chr10_+_85899184 18.210 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr19_-_59066477 18.194 NM_014453
CHMP2A
charged multivesicular body protein 2A
chr8_-_146017774 18.178 RPL8
ribosomal protein L8
chr3_+_128445026 18.153 RAB7A
RAB7A, member RAS oncogene family
chr9_-_111696173 18.075 IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr22_+_32340435 18.026 NM_003405
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr4_+_17812524 17.997 NM_022346
NCAPG
non-SMC condensin I complex, subunit G
chr11_-_6633178 17.993 TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr5_-_32174242 17.912 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr18_+_72163335 17.830 NM_018235
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr16_-_3767449 17.771 NM_016292
TRAP1
TNF receptor-associated protein 1
chr20_+_361675 17.751 TRIB3
tribbles homolog 3 (Drosophila)
chr1_-_53704121 17.689 NM_002370
MAGOH
mago-nashi homolog, proliferation-associated (Drosophila)
chr6_-_42713837 17.649 NM_003192
TBCC
tubulin folding cofactor C
chr19_+_36631001 17.550 CAPNS1
calpain, small subunit 1
chr10_-_33247131 17.459 ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr1_+_44440673 17.396 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.61 3.28e-29 GO:0044237 cellular metabolic process
1.76 8.89e-26 GO:0044260 cellular macromolecule metabolic process
1.49 1.08e-23 GO:0008152 metabolic process
1.54 2.99e-23 GO:0044238 primary metabolic process
1.63 1.60e-21 GO:0043170 macromolecule metabolic process
1.80 4.62e-19 GO:0006807 nitrogen compound metabolic process
1.82 6.38e-19 GO:0034641 cellular nitrogen compound metabolic process
1.90 1.13e-18 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.87 1.62e-15 GO:0044267 cellular protein metabolic process
1.91 1.71e-14 GO:0090304 nucleic acid metabolic process
1.22 1.39e-13 GO:0009987 cellular process
1.69 2.55e-12 GO:0019538 protein metabolic process
5.19 8.59e-10 GO:0050657 nucleic acid transport
5.19 8.59e-10 GO:0050658 RNA transport
5.19 8.59e-10 GO:0051236 establishment of RNA localization
2.39 1.25e-09 GO:0046907 intracellular transport
5.02 2.08e-09 GO:0006403 RNA localization
1.83 2.93e-09 GO:0010467 gene expression
1.55 3.55e-09 GO:0071840 cellular component organization or biogenesis
1.63 1.54e-08 GO:0071841 cellular component organization or biogenesis at cellular level
2.27 2.01e-08 GO:0033554 cellular response to stress
5.06 2.79e-08 GO:0051028 mRNA transport
4.47 4.12e-08 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.80 5.00e-08 GO:0016070 RNA metabolic process
2.44 5.20e-08 GO:0006396 RNA processing
1.52 1.01e-07 GO:0016043 cellular component organization
1.64 1.31e-07 GO:0044249 cellular biosynthetic process
1.59 3.87e-07 GO:0071842 cellular component organization at cellular level
1.77 6.16e-07 GO:0034645 cellular macromolecule biosynthetic process
1.95 7.99e-07 GO:0044248 cellular catabolic process
1.59 1.08e-06 GO:0009058 biosynthetic process
1.75 1.30e-06 GO:0009059 macromolecule biosynthetic process
2.37 2.88e-06 GO:0000278 mitotic cell cycle
1.97 4.70e-06 GO:0007049 cell cycle
1.92 5.01e-06 GO:0051649 establishment of localization in cell
2.22 5.39e-06 GO:0022403 cell cycle phase
2.89 8.19e-06 GO:0006412 translation
1.72 1.37e-05 GO:0006996 organelle organization
1.82 1.75e-05 GO:0051641 cellular localization
2.06 1.85e-05 GO:0022402 cell cycle process
2.35 1.93e-05 GO:0044265 cellular macromolecule catabolic process
3.47 3.20e-05 GO:0006913 nucleocytoplasmic transport
3.43 4.13e-05 GO:0051169 nuclear transport
4.80 4.95e-05 GO:0051168 nuclear export
1.77 5.40e-05 GO:0033036 macromolecule localization
2.69 9.62e-05 GO:0019941 modification-dependent protein catabolic process
2.67 1.14e-04 GO:0043632 modification-dependent macromolecule catabolic process
1.52 1.24e-04 GO:0048522 positive regulation of cellular process
3.17 1.30e-04 GO:0000375 RNA splicing, via transesterification reactions
1.95 1.48e-04 GO:0045184 establishment of protein localization
1.95 1.60e-04 GO:0015031 protein transport
2.62 1.90e-04 GO:0051603 proteolysis involved in cellular protein catabolic process
2.69 2.08e-04 GO:0008380 RNA splicing
2.40 2.23e-04 GO:0072521 purine-containing compound metabolic process
1.69 2.67e-04 GO:0009056 catabolic process
7.28 2.72e-04 GO:0034976 response to endoplasmic reticulum stress
5.12 2.88e-04 GO:0006986 response to unfolded protein
2.57 3.12e-04 GO:0044257 cellular protein catabolic process
3.09 3.83e-04 GO:0006457 protein folding
2.11 4.09e-04 GO:0009057 macromolecule catabolic process
2.59 5.29e-04 GO:0006511 ubiquitin-dependent protein catabolic process
1.75 6.95e-04 GO:0044085 cellular component biogenesis
1.49 7.14e-04 GO:0006950 response to stress
2.04 7.49e-04 GO:0046483 heterocycle metabolic process
3.02 9.92e-04 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
3.02 9.92e-04 GO:0000398 nuclear mRNA splicing, via spliceosome
1.77 1.39e-03 GO:0008104 protein localization
2.48 1.49e-03 GO:0009259 ribonucleotide metabolic process
1.44 1.51e-03 GO:0048518 positive regulation of biological process
2.40 1.68e-03 GO:0030163 protein catabolic process
2.50 1.80e-03 GO:0009150 purine ribonucleotide metabolic process
2.30 1.81e-03 GO:0016032 viral reproduction
2.11 2.64e-03 GO:0016071 mRNA metabolic process
4.64 2.75e-03 GO:0006405 RNA export from nucleus
2.32 2.76e-03 GO:0006397 mRNA processing
1.52 3.23e-03 GO:0043412 macromolecule modification
5.72 4.12e-03 GO:0006369 termination of RNA polymerase II transcription
2.49 4.22e-03 GO:0051329 interphase of mitotic cell cycle
2.57 4.48e-03 GO:0034660 ncRNA metabolic process
2.09 5.51e-03 GO:0006974 response to DNA damage stimulus
1.53 5.64e-03 GO:0006464 protein modification process
2.45 6.16e-03 GO:0051325 interphase
2.25 7.60e-03 GO:0006163 purine nucleotide metabolic process
2.02 7.99e-03 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
2.81 1.03e-02 GO:0022613 ribonucleoprotein complex biogenesis
6.56 1.03e-02 GO:0006984 ER-nucleus signaling pathway
1.66 1.09e-02 GO:0031325 positive regulation of cellular metabolic process
1.69 1.31e-02 GO:0010941 regulation of cell death
1.79 1.36e-02 GO:0043933 macromolecular complex subunit organization
1.70 1.41e-02 GO:0043067 regulation of programmed cell death
2.14 1.49e-02 GO:0000279 M phase
1.96 1.53e-02 GO:0006259 DNA metabolic process
2.53 1.89e-02 GO:0072523 purine-containing compound catabolic process
1.69 1.96e-02 GO:0042981 regulation of apoptosis
2.27 2.18e-02 GO:0006281 DNA repair
2.60 2.51e-02 GO:0009154 purine ribonucleotide catabolic process
2.66 2.53e-02 GO:0071843 cellular component biogenesis at cellular level
3.20 2.53e-02 GO:0051789 response to protein stimulus
8.05 2.59e-02 GO:0030968 endoplasmic reticulum unfolded protein response
8.05 2.59e-02 GO:0034620 cellular response to unfolded protein
1.60 2.84e-02 GO:0009893 positive regulation of metabolic process
2.58 2.96e-02 GO:0009261 ribonucleotide catabolic process
2.33 3.15e-02 GO:0000087 M phase of mitotic cell cycle
2.50 3.38e-02 GO:0006195 purine nucleotide catabolic process
1.91 3.45e-02 GO:0071822 protein complex subunit organization
1.66 3.60e-02 GO:0022607 cellular component assembly
1.48 3.72e-02 GO:0044281 small molecule metabolic process
1.99 3.76e-02 GO:0006753 nucleoside phosphate metabolic process
1.99 3.76e-02 GO:0009117 nucleotide metabolic process
1.73 4.00e-02 GO:0008219 cell death
2.42 4.38e-02 GO:0009166 nucleotide catabolic process
2.52 4.42e-02 GO:0051129 negative regulation of cellular component organization
2.00 4.48e-02 GO:0034621 cellular macromolecular complex subunit organization
2.57 4.54e-02 GO:0000075 cell cycle checkpoint
1.72 4.67e-02 GO:0016265 death
2.36 4.76e-02 GO:0010608 posttranscriptional regulation of gene expression
2.95 4.87e-02 GO:0031396 regulation of protein ubiquitination
4.16 4.95e-02 GO:0031124 mRNA 3'-end processing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 1.28e-26 GO:0005737 cytoplasm
1.28 2.30e-26 GO:0044424 intracellular part
1.25 3.16e-23 GO:0005622 intracellular
1.56 5.93e-22 GO:0044422 organelle part
1.56 6.83e-22 GO:0044446 intracellular organelle part
1.35 1.52e-20 GO:0043231 intracellular membrane-bounded organelle
1.35 2.05e-20 GO:0043227 membrane-bounded organelle
2.03 1.19e-19 GO:0044428 nuclear part
1.50 1.92e-19 GO:0044444 cytoplasmic part
1.30 4.31e-18 GO:0043229 intracellular organelle
2.01 6.24e-18 GO:0005829 cytosol
1.29 7.09e-18 GO:0043226 organelle
1.92 4.16e-17 GO:0031974 membrane-enclosed lumen
1.92 1.27e-16 GO:0070013 intracellular organelle lumen
1.91 2.02e-16 GO:0043233 organelle lumen
2.02 8.59e-16 GO:0031981 nuclear lumen
2.17 5.93e-14 GO:0005654 nucleoplasm
1.45 1.31e-13 GO:0005634 nucleus
1.57 2.76e-11 GO:0032991 macromolecular complex
2.13 2.92e-06 GO:0031967 organelle envelope
2.29 3.27e-06 GO:0005694 chromosome
2.32 5.45e-06 GO:0030529 ribonucleoprotein complex
2.09 5.84e-06 GO:0031975 envelope
1.45 2.52e-05 GO:0043234 protein complex
1.46 3.94e-05 GO:0043228 non-membrane-bounded organelle
1.46 3.94e-05 GO:0043232 intracellular non-membrane-bounded organelle
2.88 4.48e-05 GO:0005635 nuclear envelope
2.20 1.12e-04 GO:0005730 nucleolus
2.19 3.71e-04 GO:0044427 chromosomal part
4.43 8.99e-04 GO:0005643 nuclear pore
4.15 9.53e-04 GO:0071013 catalytic step 2 spliceosome
3.14 2.05e-03 GO:0000793 condensed chromosome
3.10 2.56e-03 GO:0031965 nuclear membrane
1.44 3.67e-03 GO:0031090 organelle membrane
3.73 3.82e-03 GO:0000776 kinetochore
3.10 4.34e-03 GO:0005681 spliceosomal complex
17.48 7.88e-03 GO:0005663 DNA replication factor C complex
3.69 8.47e-03 GO:0046930 pore complex
2.92 1.00e-02 GO:0000775 chromosome, centromeric region
1.48 1.68e-02 GO:0012505 endomembrane system
3.44 1.90e-02 GO:0042470 melanosome
3.44 1.90e-02 GO:0048770 pigment granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.52 9.37e-31 GO:0005515 protein binding
1.22 1.99e-19 GO:0005488 binding
1.74 3.85e-11 GO:0000166 nucleotide binding
2.27 1.61e-09 GO:0003723 RNA binding
1.77 2.60e-09 GO:0035639 purine ribonucleoside triphosphate binding
1.76 3.24e-09 GO:0017076 purine nucleotide binding
1.76 4.33e-09 GO:0032553 ribonucleotide binding
1.76 4.33e-09 GO:0032555 purine ribonucleotide binding
1.78 1.36e-07 GO:0030554 adenyl nucleotide binding
1.79 1.56e-07 GO:0005524 ATP binding
1.78 1.96e-07 GO:0032559 adenyl ribonucleotide binding
1.33 2.13e-06 GO:0003824 catalytic activity
4.15 1.21e-03 GO:0031625 ubiquitin protein ligase binding
1.82 3.18e-03 GO:0019899 enzyme binding
1.99 1.47e-02 GO:0016874 ligase activity
1.74 1.70e-02 GO:0017111 nucleoside-triphosphatase activity
1.71 2.53e-02 GO:0016462 pyrophosphatase activity
3.09 2.70e-02 GO:0051082 unfolded protein binding
1.70 2.83e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.69 3.16e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
2.44 3.58e-02 GO:0003924 GTPase activity
21.85 4.54e-02 GO:0005049 nuclear export signal receptor activity