Motif ID: ATF5_CREB3.p2

Z-value: 3.226


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CREB3chr9_+_357326290.235.0e-04Click!
ATF5chr19_+_50431958-0.101.3e-01Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_123380608 137.756


chr19_+_16187047 76.118 NM_003290
TPM4
tropomyosin 4
chr8_-_17104266 73.607 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr17_-_685385 73.480 NM_016080
GLOD4
glyoxalase domain containing 4
chr19_+_16187306 70.349 TPM4
tropomyosin 4
chr5_+_138211084 68.554 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr8_-_17104103 66.190 CNOT7
CCR4-NOT transcription complex, subunit 7
chr3_+_38206968 65.284 NM_005109
OXSR1
oxidative-stress responsive 1
chr12_+_69004684 64.073 RAP1B
RAP1B, member of RAS oncogene family
chr11_+_4116059 63.841 RRM1
ribonucleotide reductase M1
chr2_+_172821874 62.892 HAT1
histone acetyltransferase 1
chr12_+_69004710 60.552 RAP1B
RAP1B, member of RAS oncogene family
chr19_+_16187266 60.115 TPM4
tropomyosin 4
chr1_-_53704121 59.151 NM_002370
MAGOH
mago-nashi homolog, proliferation-associated (Drosophila)
chr19_+_16187315 58.465 TPM4
tropomyosin 4
chr11_+_4116077 54.788 RRM1
ribonucleotide reductase M1
chr11_+_4115923 53.319 NM_001033
RRM1
ribonucleotide reductase M1
chr5_-_133561745 52.302 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr6_-_53213586 49.711 ELOVL5
ELOVL fatty acid elongase 5
chr19_+_1941157 49.708 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr12_+_72148653 49.436 NM_014999
RAB21
RAB21, member RAS oncogene family
chr1_+_26496382 48.626 NM_015871
ZNF593
zinc finger protein 593
chr10_-_97416367 48.491 ALDH18A1
aldehyde dehydrogenase 18 family, member A1
chr11_+_18416111 48.246 LDHA
lactate dehydrogenase A
chr11_+_18416106 47.585 LDHA
lactate dehydrogenase A
chr3_-_150263899 45.810 SERP1
stress-associated endoplasmic reticulum protein 1
chr8_-_101964268 45.667 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_-_245025958 44.753 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr3_-_185655833 44.630 NM_001243879
NM_004593
TRA2B

transformer 2 beta homolog (Drosophila)

chr4_+_113558119 44.133 NM_016648
LARP7
La ribonucleoprotein domain family, member 7
chr3_-_195808934 44.060 TFRC
transferrin receptor (p90, CD71)
chr3_+_170075521 43.819 SKIL
SKI-like oncogene
chr8_-_117768032 43.729 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr8_-_101964247 43.700 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964236 43.510 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964248 43.357 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_69004614 43.279 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
RAP1B





RAP1B, member of RAS oncogene family





chr8_-_117768059 43.044 NM_003756
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr1_+_52082755 42.934 OSBPL9
oxysterol binding protein-like 9
chr14_+_105219466 42.771 NM_006427
NM_021709
SIVA1

SIVA1, apoptosis-inducing factor

chr3_-_185655806 42.726 TRA2B
transformer 2 beta homolog (Drosophila)
chr5_-_133561551 42.704 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr3_-_185655648 42.046 TRA2B
transformer 2 beta homolog (Drosophila)
chr3_-_195808997 41.742 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr8_+_26149080 41.718 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_228327982 41.341 GUK1
guanylate kinase 1
chr2_-_10588273 41.286 ODC1
ornithine decarboxylase 1
chr3_-_195808958 41.256 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr8_-_101964258 41.231 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_228327966 40.406 GUK1
guanylate kinase 1
chr2_-_98408868 40.305 TMEM131
transmembrane protein 131
chr21_-_44846927 39.535 NM_173354
SIK1
salt-inducible kinase 1
chr1_-_32110464 39.334 PEF1
penta-EF-hand domain containing 1
chr2_-_10588451 39.259 NM_002539
ODC1
ornithine decarboxylase 1
chr8_-_101964334 39.216 NM_145690
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_-_25164902 38.524 NM_018947
CYCS
cytochrome c, somatic
chr1_-_19536741 38.438 NM_020765
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr12_-_14956367 38.409 NM_016312
WBP11
WW domain binding protein 11
chr1_+_228328003 38.237 GUK1
guanylate kinase 1
chr2_+_118572254 37.826 NM_006773
DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr11_-_6633400 37.774 TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr8_-_101964197 37.696 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_-_89357181 37.685 GTF2B
general transcription factor IIB
chr16_+_31044414 37.647 STX4
syntaxin 4
chr12_-_6862131 37.494 MLF2
myeloid leukemia factor 2
chr15_-_91537724 37.085 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr15_+_80352018 37.024 ZFAND6
zinc finger, AN1-type domain 6
chr6_+_47445440 37.022 NM_012120
CD2AP
CD2-associated protein
chr12_-_132628841 36.944 NM_175066
DDX51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr10_-_97416564 36.669 NM_001017423
NM_002860
ALDH18A1

aldehyde dehydrogenase 18 family, member A1

chr6_-_90062439 36.394 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr12_-_14956315 36.152 WBP11
WW domain binding protein 11
chr3_-_186524226 35.978 NM_002916
RFC4
replication factor C (activator 1) 4, 37kDa
chr5_-_133561805 35.785 NM_002715
PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr2_+_118572283 35.656 DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr16_+_2564000 35.532 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr6_+_44214786 35.499 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr6_-_90062349 35.404 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr1_-_150602041 35.397 ENSA
endosulfine alpha
chr20_+_19915716 35.132 RIN2
Ras and Rab interactor 2
chr12_-_14956408 35.100 WBP11
WW domain binding protein 11
chr11_-_8680382 34.456 NM_014818
TRIM66
tripartite motif containing 66
chr1_+_228327784 34.441 NM_001242839
NM_000858
NM_001159390
NM_001242840
GUK1



guanylate kinase 1



chr2_+_118572284 34.405 DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr12_+_132629014 34.328 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr5_+_177631533 34.273 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr3_-_57583080 34.153 ARF4
ADP-ribosylation factor 4
chr8_+_64081108 34.108 NM_152758
YTHDF3
YTH domain family, member 3
chr1_+_228328015 34.074 GUK1
guanylate kinase 1
chr18_+_20513277 33.892 NM_002894
RBBP8
retinoblastoma binding protein 8
chr17_-_48474678 33.694 LRRC59
leucine rich repeat containing 59
chr7_+_117824085 33.654 NM_016200
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr17_-_48474910 33.579 NM_018509
LRRC59
leucine rich repeat containing 59
chr2_-_64881040 33.031 NM_014755
SERTAD2
SERTA domain containing 2
chr15_+_66679107 33.007 NM_002755
MAP2K1
mitogen-activated protein kinase kinase 1
chr8_+_64081187 32.555 YTHDF3
YTH domain family, member 3
chr5_+_10353980 32.394


chr15_+_80351909 32.211 NM_001242911
NM_001242912
NM_001242917
NM_001242918
NM_019006
ZFAND6




zinc finger, AN1-type domain 6




chr12_-_82752154 31.892 NM_014167
CCDC59
coiled-coil domain containing 59
chr10_-_75006963 31.861 NM_015190
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr6_+_64281910 31.807 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr12_-_123380682 31.754 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr15_+_80352257 31.610 NM_001242913
ZFAND6
zinc finger, AN1-type domain 6
chr3_-_185655776 31.438 TRA2B
transformer 2 beta homolog (Drosophila)
chr12_+_108079516 31.212 NM_007062
PWP1
PWP1 homolog (S. cerevisiae)
chr7_+_56019552 31.021 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr10_+_112257624 30.916 NM_004419
DUSP5
dual specificity phosphatase 5
chr6_+_44214853 30.866 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr5_+_177631534 30.754 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr4_-_104119475 30.682 NM_001813
CENPE
centromere protein E, 312kDa
chr17_+_57697036 30.646 NM_004859
CLTC
clathrin, heavy chain (Hc)
chr17_+_33914278 30.516 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr2_-_240964717 30.308 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr7_+_107531585 30.233 NM_000108
DLD
dihydrolipoamide dehydrogenase
chr1_+_162531349 30.152 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr4_+_113558611 30.035 NM_015454
LARP7
La ribonucleoprotein domain family, member 7
chr15_-_23034307 29.980 NIPA2
non imprinted in Prader-Willi/Angelman syndrome 2
chr15_+_80352043 29.965 ZFAND6
zinc finger, AN1-type domain 6
chr11_+_74660290 29.815 NM_014752
LOC653566
SPCS2
signal peptidase complex subunit 2 homolog pseudogene
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr4_+_146019368 29.795 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr12_-_6862081 29.762 NM_005439
MLF2
myeloid leukemia factor 2
chr6_-_86352650 29.725 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr3_+_152017193 29.678 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr2_-_62115714 29.547 CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr4_-_122744782 29.517 CCNA2
cyclin A2
chr1_-_43736600 29.499 EBNA1BP2
EBNA1 binding protein 2
chr4_-_122744978 29.405 NM_001237
CCNA2
cyclin A2
chr6_-_31774579 29.326 LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr6_-_31774725 29.149 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_-_1822501 28.906 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr2_+_187350870 28.897 NM_018471
ZC3H15
zinc finger CCCH-type containing 15
chr18_+_158480 28.820 NM_001037334
NM_005151
USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr12_-_46766019 28.802 SLC38A2
solute carrier family 38, member 2
chr14_+_100705101 28.774 NM_003403
YY1
YY1 transcription factor
chr5_+_139889635 28.670


chr2_-_240964807 28.644 NM_004544
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr7_-_25164869 28.542 CYCS
cytochrome c, somatic
chr7_+_107531618 28.540 DLD
dihydrolipoamide dehydrogenase
chr19_+_10362886 28.516 MRPL4
mitochondrial ribosomal protein L4
chr6_+_111195986 28.363 NM_001634
NM_001033059
AMD1

adenosylmethionine decarboxylase 1

chr7_+_107531616 28.331 DLD
dihydrolipoamide dehydrogenase
chr11_-_14521328 28.305 COPB1
coatomer protein complex, subunit beta 1
chr19_-_47617008 28.113 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chrX_-_16887974 28.084 NM_001198719
RBBP7
retinoblastoma binding protein 7
chr6_+_64282449 28.044 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_39456887 27.985 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr11_-_14521386 27.831 NM_016451
NM_001144062
NM_001144061
COPB1


coatomer protein complex, subunit beta 1


chr3_+_44803280 27.826 KIF15
kinesin family member 15
chr6_-_86352656 27.784 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr7_+_26240830 27.761 NM_007276
CBX3
chromobox homolog 3
chr15_+_66797632 27.396 ZWILCH
Zwilch, kinetochore associated, homolog (Drosophila)
chr6_-_32812711 27.263 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr4_+_146019486 27.223 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr17_+_685512 27.152 NM_018146
RNMTL1
RNA methyltransferase like 1
chr13_+_114239047 27.136 NM_007111
TFDP1
transcription factor Dp-1
chr2_-_62115726 27.131 CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr17_+_66508525 27.090 NM_002734
NM_212472
PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

chr6_-_7910716 27.062 NM_030810
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr19_-_55918980 27.027 UBE2S
ubiquitin-conjugating enzyme E2S
chr7_+_100273776 26.985 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr5_-_137878808 26.831 ETF1
eukaryotic translation termination factor 1
chr19_+_49375679 26.813 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr17_-_17184500 26.693 COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr3_-_57582866 26.678 ARF4
ADP-ribosylation factor 4
chr2_+_187351032 26.649 ZC3H15
zinc finger CCCH-type containing 15
chr17_+_40985444 26.625 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr14_+_93651295 26.539 NM_015676
NM_001098621
C14orf109

chromosome 14 open reading frame 109

chr10_-_111683201 26.520 XPNPEP1
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr6_+_24775154 26.442 NM_001251989
NM_001251990
NM_015895
GMNN


geminin, DNA replication inhibitor


chr6_-_32812409 26.374 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr11_+_74660317 26.346 SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr2_-_62115641 26.191 CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr19_+_49375677 26.171 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr3_+_101292987 26.155 PCNP
PEST proteolytic signal containing nuclear protein
chr7_-_66057331 26.116 LOC493754
RAB guanine nucleotide exchange factor (GEF) 1 pseudogene
chr8_-_121457625 26.115 NM_014078
MRPL13
mitochondrial ribosomal protein L13
chr8_-_103876390 26.061 NM_015878
NM_148174
AZIN1

antizyme inhibitor 1

chr6_+_30585485 26.041 NM_014046
MRPS18B
mitochondrial ribosomal protein S18B
chr11_-_61584451 25.769 NM_013402
FADS1
fatty acid desaturase 1
chr19_+_49375638 25.718 NM_014330
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr1_+_161284165 25.711 NM_001035511
NM_001035512
NM_001035513
NM_003001
SDHC



succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa



chr3_-_52312655 25.710 NM_025222
WDR82
WD repeat domain 82
chr8_-_121457387 25.695 MRPL13
mitochondrial ribosomal protein L13
chr17_+_57642885 25.575 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr2_+_109271267 25.384 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_-_111683245 25.352 NM_001167604
NM_020383
XPNPEP1

X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

chr2_-_3605918 25.289 RNASEH1
ribonuclease H1
chr3_+_52719935 25.213 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr2_+_172778907 25.157 NM_003642
HAT1
histone acetyltransferase 1
chr8_-_121457333 25.138 MRPL13
mitochondrial ribosomal protein L13
chr14_+_35452103 24.998 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr17_+_685606 24.903 RNMTL1
RNA methyltransferase like 1
chr12_-_46766563 24.801 NM_018976
SLC38A2
solute carrier family 38, member 2
chr1_+_52082545 24.759 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr11_-_65667858 24.636 FOSL1
FOS-like antigen 1
chr1_-_1822493 24.602 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr11_+_74660321 24.559 SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr5_-_133340427 24.493 VDAC1
voltage-dependent anion channel 1
chr3_+_45017749 24.454 EXOSC7
exosome component 7
chr4_+_146019155 24.422 NM_001040876
NM_002940
ABCE1

ATP-binding cassette, sub-family E (OABP), member 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.54 9.54e-44 GO:0044237 cellular metabolic process
1.68 1.55e-39 GO:0044260 cellular macromolecule metabolic process
1.43 3.96e-35 GO:0008152 metabolic process
1.25 8.54e-34 GO:0009987 cellular process
1.56 5.20e-32 GO:0043170 macromolecule metabolic process
1.45 1.22e-31 GO:0044238 primary metabolic process
1.75 1.28e-25 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64 1.60e-22 GO:0034641 cellular nitrogen compound metabolic process
1.80 4.50e-22 GO:0090304 nucleic acid metabolic process
1.61 2.05e-21 GO:0006807 nitrogen compound metabolic process
1.80 1.22e-17 GO:0010467 gene expression
1.84 1.95e-17 GO:0009059 macromolecule biosynthetic process
2.31 2.15e-17 GO:0046907 intracellular transport
1.84 4.38e-17 GO:0034645 cellular macromolecule biosynthetic process
1.65 4.86e-17 GO:0044267 cellular protein metabolic process
1.64 1.53e-15 GO:0044249 cellular biosynthetic process
2.01 2.16e-15 GO:0051649 establishment of localization in cell
1.61 4.74e-15 GO:0009058 biosynthetic process
1.77 5.11e-15 GO:0016070 RNA metabolic process
1.49 2.44e-14 GO:0071840 cellular component organization or biogenesis
1.90 2.59e-14 GO:0051641 cellular localization
1.90 1.42e-12 GO:0044248 cellular catabolic process
1.46 4.87e-12 GO:0016043 cellular component organization
1.52 7.01e-12 GO:0071841 cellular component organization or biogenesis at cellular level
1.49 1.45e-11 GO:0019538 protein metabolic process
1.99 6.58e-11 GO:0045184 establishment of protein localization
1.99 9.03e-11 GO:0015031 protein transport
2.30 9.74e-11 GO:0044265 cellular macromolecule catabolic process
2.14 3.30e-10 GO:0006396 RNA processing
1.75 3.78e-10 GO:0033036 macromolecule localization
1.71 5.40e-10 GO:0009056 catabolic process
2.14 1.12e-09 GO:0009057 macromolecule catabolic process
1.49 1.44e-09 GO:0071842 cellular component organization at cellular level
1.84 2.00e-09 GO:0007049 cell cycle
2.43 3.32e-09 GO:0006886 intracellular protein transport
1.81 3.77e-09 GO:0008104 protein localization
1.62 1.10e-08 GO:0006996 organelle organization
1.95 2.11e-08 GO:0016192 vesicle-mediated transport
2.51 2.64e-08 GO:0019941 modification-dependent protein catabolic process
1.90 3.39e-08 GO:0022402 cell cycle process
2.50 3.55e-08 GO:0043632 modification-dependent macromolecule catabolic process
2.45 8.47e-08 GO:0051603 proteolysis involved in cellular protein catabolic process
2.48 9.89e-08 GO:0006511 ubiquitin-dependent protein catabolic process
2.12 1.45e-07 GO:0070727 cellular macromolecule localization
2.49 1.77e-07 GO:0008380 RNA splicing
3.33 1.90e-07 GO:0048193 Golgi vesicle transport
2.40 1.96e-07 GO:0044257 cellular protein catabolic process
2.04 2.18e-07 GO:0000278 mitotic cell cycle
2.11 2.57e-07 GO:0034613 cellular protein localization
1.69 3.66e-07 GO:0044085 cellular component biogenesis
2.05 7.89e-07 GO:0016071 mRNA metabolic process
2.25 9.00e-07 GO:0006397 mRNA processing
2.78 9.56e-07 GO:0000375 RNA splicing, via transesterification reactions
2.28 1.27e-06 GO:0030163 protein catabolic process
2.75 1.36e-06 GO:0006605 protein targeting
1.80 1.85e-06 GO:0033554 cellular response to stress
1.89 2.47e-06 GO:0022403 cell cycle phase
1.42 3.17e-06 GO:0006950 response to stress
2.73 4.62e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.73 4.62e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
1.70 9.63e-06 GO:0032774 RNA biosynthetic process
2.45 9.66e-06 GO:0009166 nucleotide catabolic process
2.26 1.26e-05 GO:0009259 ribonucleotide metabolic process
2.24 1.82e-05 GO:0070647 protein modification by small protein conjugation or removal
2.53 2.13e-05 GO:0009261 ribonucleotide catabolic process
2.62 2.48e-05 GO:0006457 protein folding
2.33 3.94e-05 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
2.33 3.94e-05 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
2.11 4.22e-05 GO:0006163 purine nucleotide metabolic process
2.50 4.79e-05 GO:0009154 purine ribonucleotide catabolic process
2.41 5.04e-05 GO:0072523 purine-containing compound catabolic process
1.46 5.67e-05 GO:0006464 protein modification process
2.22 6.01e-05 GO:0009150 purine ribonucleotide metabolic process
2.42 6.31e-05 GO:0006195 purine nucleotide catabolic process
5.01 6.61e-05 GO:0006888 ER to Golgi vesicle-mediated transport
1.68 1.14e-04 GO:0006351 transcription, DNA-dependent
1.43 1.23e-04 GO:0043412 macromolecule modification
1.84 1.59e-04 GO:0071822 protein complex subunit organization
2.43 2.34e-04 GO:0009203 ribonucleoside triphosphate catabolic process
2.43 2.34e-04 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.24 2.52e-04 GO:0032446 protein modification by small protein conjugation
2.42 2.70e-04 GO:0009146 purine nucleoside triphosphate catabolic process
2.58 2.83e-04 GO:0006913 nucleocytoplasmic transport
2.17 3.14e-04 GO:0006412 translation
1.59 3.19e-04 GO:0022607 cellular component assembly
2.16 3.52e-04 GO:0044270 cellular nitrogen compound catabolic process
2.55 3.85e-04 GO:0051169 nuclear transport
2.38 4.07e-04 GO:0009143 nucleoside triphosphate catabolic process
1.79 4.11e-04 GO:0051726 regulation of cell cycle
1.32 4.12e-04 GO:0051234 establishment of localization
2.88 4.41e-04 GO:0051789 response to protein stimulus
1.96 4.99e-04 GO:0072521 purine-containing compound metabolic process
2.15 5.62e-04 GO:0046700 heterocycle catabolic process
2.90 6.22e-04 GO:0050657 nucleic acid transport
2.90 6.22e-04 GO:0050658 RNA transport
2.90 6.22e-04 GO:0051236 establishment of RNA localization
2.16 6.40e-04 GO:0009144 purine nucleoside triphosphate metabolic process
1.31 6.81e-04 GO:0006810 transport
2.62 7.11e-04 GO:0010498 proteasomal protein catabolic process
2.62 7.11e-04 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.28 8.64e-04 GO:0051179 localization
1.63 9.08e-04 GO:0008219 cell death
1.35 9.54e-04 GO:0048522 positive regulation of cellular process
1.85 9.85e-04 GO:0006753 nucleoside phosphate metabolic process
1.85 9.85e-04 GO:0009117 nucleotide metabolic process
3.68 1.06e-03 GO:0031124 mRNA 3'-end processing
1.80 1.08e-03 GO:0050878 regulation of body fluid levels
2.14 1.14e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.63 1.16e-03 GO:0016265 death
2.13 1.27e-03 GO:0009199 ribonucleoside triphosphate metabolic process
2.80 1.30e-03 GO:0006403 RNA localization
2.11 1.39e-03 GO:0009141 nucleoside triphosphate metabolic process
3.62 1.40e-03 GO:0006986 response to unfolded protein
2.50 1.45e-03 GO:0043687 post-translational protein modification
1.15 1.91e-03 GO:0065007 biological regulation
1.17 2.13e-03 GO:0050794 regulation of cellular process
1.54 2.52e-03 GO:0051246 regulation of protein metabolic process
1.55 2.69e-03 GO:0032268 regulation of cellular protein metabolic process
2.08 2.71e-03 GO:0048285 organelle fission
1.16 2.74e-03 GO:0050789 regulation of biological process
5.59 2.77e-03 GO:0006901 vesicle coating
6.10 3.18e-03 GO:0048199 vesicle targeting, to, from or within Golgi
1.61 3.30e-03 GO:0043933 macromolecular complex subunit organization
1.82 3.30e-03 GO:0007596 blood coagulation
1.82 3.30e-03 GO:0050817 coagulation
2.16 3.42e-03 GO:0016567 protein ubiquitination
1.81 4.19e-03 GO:0007599 hemostasis
1.87 4.40e-03 GO:0000279 M phase
2.83 4.45e-03 GO:0051028 mRNA transport
5.37 4.57e-03 GO:0006900 membrane budding
3.25 4.67e-03 GO:0031123 RNA 3'-end processing
1.27 4.71e-03 GO:0060255 regulation of macromolecule metabolic process
2.58 4.84e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.56 5.65e-03 GO:0006184 GTP catabolic process
2.04 5.80e-03 GO:0000087 M phase of mitotic cell cycle
2.06 6.03e-03 GO:0000280 nuclear division
2.06 6.03e-03 GO:0007067 mitosis
1.30 6.56e-03 GO:0048518 positive regulation of biological process
2.25 7.13e-03 GO:0033365 protein localization to organelle
1.38 7.24e-03 GO:0044281 small molecule metabolic process
1.25 7.67e-03 GO:0031323 regulation of cellular metabolic process
1.64 8.59e-03 GO:0006915 apoptosis
1.63 8.84e-03 GO:0012501 programmed cell death
1.73 9.12e-03 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.34 9.65e-03 GO:0048523 negative regulation of cellular process
1.82 1.09e-02 GO:0016044 cellular membrane organization
1.46 1.24e-02 GO:0010033 response to organic substance
3.18 1.25e-02 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
1.81 1.27e-02 GO:0061024 membrane organization
2.00 1.34e-02 GO:0051329 interphase of mitotic cell cycle
1.61 1.48e-02 GO:0071844 cellular component assembly at cellular level
1.83 1.74e-02 GO:0016032 viral reproduction
1.69 1.75e-02 GO:0006259 DNA metabolic process
1.74 1.76e-02 GO:0006974 response to DNA damage stimulus
2.41 2.11e-02 GO:0046039 GTP metabolic process
3.18 2.14e-02 GO:0034130 toll-like receptor 1 signaling pathway
3.18 2.14e-02 GO:0034134 toll-like receptor 2 signaling pathway
1.96 2.17e-02 GO:0051325 interphase
3.05 2.37e-02 GO:0034142 toll-like receptor 4 signaling pathway
2.13 2.56e-02 GO:0071156 regulation of cell cycle arrest
2.15 2.61e-02 GO:0000075 cell cycle checkpoint
1.22 3.69e-02 GO:0019222 regulation of metabolic process
2.87 3.69e-02 GO:0002224 toll-like receptor signaling pathway
1.24 3.74e-02 GO:0080090 regulation of primary metabolic process
4.47 3.82e-02 GO:0006984 ER-nucleus signaling pathway
1.73 3.84e-02 GO:0006461 protein complex assembly
2.50 4.44e-02 GO:0045333 cellular respiration
1.69 4.65e-02 GO:0044282 small molecule catabolic process
1.72 4.74e-02 GO:0070271 protein complex biogenesis
1.47 4.87e-02 GO:0010941 regulation of cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 5.98e-45 GO:0044424 intracellular part
1.25 8.09e-41 GO:0005622 intracellular
1.35 1.00e-38 GO:0043231 intracellular membrane-bounded organelle
1.35 1.75e-38 GO:0043227 membrane-bounded organelle
1.53 4.02e-37 GO:0044446 intracellular organelle part
1.37 1.09e-36 GO:0005737 cytoplasm
1.52 1.59e-36 GO:0044422 organelle part
1.29 3.31e-32 GO:0043229 intracellular organelle
1.28 8.10e-32 GO:0043226 organelle
1.44 2.24e-28 GO:0044444 cytoplasmic part
1.89 4.66e-28 GO:0044428 nuclear part
1.88 1.15e-22 GO:0031981 nuclear lumen
1.75 3.13e-22 GO:0031974 membrane-enclosed lumen
1.74 1.81e-21 GO:0043233 organelle lumen
1.75 2.84e-21 GO:0070013 intracellular organelle lumen
1.39 2.10e-19 GO:0005634 nucleus
1.93 2.75e-17 GO:0005654 nucleoplasm
1.70 3.67e-17 GO:0005829 cytosol
1.49 1.91e-16 GO:0032991 macromolecular complex
1.43 1.24e-09 GO:0043234 protein complex
1.51 3.32e-09 GO:0031090 organelle membrane
2.07 6.29e-08 GO:0030529 ribonucleoprotein complex
1.40 1.06e-07 GO:0043228 non-membrane-bounded organelle
1.40 1.06e-07 GO:0043232 intracellular non-membrane-bounded organelle
1.55 1.48e-07 GO:0012505 endomembrane system
2.00 1.67e-07 GO:0005694 chromosome
1.06 7.12e-07 GO:0044464 cell part
1.06 7.40e-07 GO:0005623 cell
2.06 8.82e-07 GO:0044427 chromosomal part
7.46 9.62e-06 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.61 1.03e-05 GO:0005783 endoplasmic reticulum
1.75 1.94e-05 GO:0044451 nucleoplasm part
1.70 1.33e-04 GO:0031967 organelle envelope
1.69 1.59e-04 GO:0031975 envelope
1.85 5.17e-04 GO:0005768 endosome
1.63 5.26e-04 GO:0031410 cytoplasmic vesicle
1.79 6.58e-04 GO:0005730 nucleolus
1.66 8.58e-04 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.59 1.25e-03 GO:0031982 vesicle
1.62 1.28e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
2.55 1.62e-03 GO:0005681 spliceosomal complex
1.52 1.82e-03 GO:0005794 Golgi apparatus
3.62 1.94e-03 GO:0005798 Golgi-associated vesicle
1.64 2.02e-03 GO:0005789 endoplasmic reticulum membrane
1.59 2.79e-03 GO:0031988 membrane-bounded vesicle
1.67 2.84e-03 GO:0044431 Golgi apparatus part
9.15 3.45e-03 GO:0030127 COPII vesicle coat
1.58 4.01e-03 GO:0044432 endoplasmic reticulum part
6.10 6.73e-03 GO:0012507 ER to Golgi transport vesicle membrane
2.03 8.58e-03 GO:0005635 nuclear envelope
3.42 1.57e-02 GO:0030658 transport vesicle membrane
2.44 1.69e-02 GO:0016607 nuclear speck
3.76 2.04e-02 GO:0030120 vesicle coat
2.01 2.18e-02 GO:0016604 nuclear body
2.56 2.42e-02 GO:0030133 transport vesicle
2.11 2.63e-02 GO:0005819 spindle
2.78 2.66e-02 GO:0071013 catalytic step 2 spliceosome
2.28 2.73e-02 GO:0000793 condensed chromosome
5.14 3.16e-02 GO:0030134 ER to Golgi transport vesicle
1.37 4.05e-02 GO:0005739 mitochondrion
2.61 4.30e-02 GO:0042470 melanosome
2.61 4.30e-02 GO:0048770 pigment granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.46 9.32e-44 GO:0005515 protein binding
1.17 3.98e-20 GO:0005488 binding
1.58 2.54e-13 GO:0000166 nucleotide binding
2.01 8.13e-12 GO:0003723 RNA binding
1.55 2.96e-09 GO:0017076 purine nucleotide binding
1.54 5.21e-09 GO:0032553 ribonucleotide binding
1.54 5.21e-09 GO:0032555 purine ribonucleotide binding
1.55 5.51e-09 GO:0035639 purine ribonucleoside triphosphate binding
1.81 4.59e-07 GO:0016462 pyrophosphatase activity
1.80 5.81e-07 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.79 7.35e-07 GO:0016817 hydrolase activity, acting on acid anhydrides
1.81 9.55e-07 GO:0017111 nucleoside-triphosphatase activity
1.23 9.82e-06 GO:0003824 catalytic activity
1.31 2.07e-05 GO:0003676 nucleic acid binding
1.48 2.76e-05 GO:0030554 adenyl nucleotide binding
1.47 5.02e-05 GO:0032559 adenyl ribonucleotide binding
1.47 7.57e-05 GO:0005524 ATP binding
2.37 1.65e-04 GO:0003924 GTPase activity
2.12 3.04e-03 GO:0019787 small conjugating protein ligase activity
1.59 4.32e-03 GO:0019899 enzyme binding
1.84 7.39e-03 GO:0005525 GTP binding
1.94 7.72e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.96 1.29e-02 GO:0016881 acid-amino acid ligase activity
1.73 1.42e-02 GO:0019904 protein domain specific binding
2.86 1.55e-02 GO:0008135 translation factor activity, nucleic acid binding
1.79 1.77e-02 GO:0019001 guanyl nucleotide binding
1.79 1.77e-02 GO:0032561 guanyl ribonucleotide binding
1.69 2.43e-02 GO:0016874 ligase activity
2.02 2.56e-02 GO:0004842 ubiquitin-protein ligase activity
2.48 2.62e-02 GO:0051082 unfolded protein binding
3.76 2.92e-02 GO:0019783 small conjugating protein-specific protease activity