Motif ID: ATF6.p2

Z-value: 2.012


Transcription factors associated with ATF6.p2:

Gene SymbolEntrez IDGene Name
ATF6 22926 activating transcription factor 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF6chr1_+_1617361090.309.2e-06Click!


Activity profile for motif ATF6.p2.

activity profile for motif ATF6.p2


Sorted Z-values histogram for motif ATF6.p2

Sorted Z-values for motif ATF6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF6.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_94024201 40.223 COL1A2
collagen, type I, alpha 2
chr7_+_94023872 28.277 NM_000089
COL1A2
collagen, type I, alpha 2
chrX_+_47441802 24.019 TIMP1
TIMP metallopeptidase inhibitor 1
chr17_-_46688279 23.157 HOXB7
homeobox B7
chrX_+_47441650 21.055 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr7_+_64498643 20.937 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr13_+_113951537 20.458 LAMP1
lysosomal-associated membrane protein 1
chr5_-_172198160 20.134 NM_004417
DUSP1
dual specificity phosphatase 1
chr3_+_100211554 19.667 TMEM45A
transmembrane protein 45A
chr3_+_100211408 19.651 NM_018004
TMEM45A
transmembrane protein 45A
chr2_+_28615695 19.592 FOSL2
FOS-like antigen 2
chr6_+_7590405 19.549 NM_152551
SNRNP48
small nuclear ribonucleoprotein 48kDa (U11/U12)
chr20_-_39766522 19.535


chr9_+_74526527 18.630 C9orf85
chromosome 9 open reading frame 85
chr6_-_108145507 18.009 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr7_-_6523689 17.887 NM_001100603
NM_006854
KDELR2

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

chr16_+_69796237 17.700 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr13_+_45915479 17.245 LOC100190939
uncharacterized LOC100190939
chr5_-_133706717 16.635 CDKL3
cyclin-dependent kinase-like 3
chr2_-_216300770 16.162 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr9_-_131709783 15.904 NM_014908
DOLK
dolichol kinase
chr3_-_187463227 15.506 BCL6
B-cell CLL/lymphoma 6
chr2_+_28615668 15.360 FOSL2
FOS-like antigen 2
chr16_-_3627353 15.251 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr14_+_74551655 15.015 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr5_-_132299263 14.843 NM_014423
AFF4
AF4/FMR2 family, member 4
chrX_-_100914816 14.840 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr18_+_72922725 14.510 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr2_+_28615771 14.467 NM_005253
FOSL2
FOS-like antigen 2
chr3_-_187463474 14.097 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr11_-_59383179 13.852 OSBP
oxysterol binding protein
chr5_-_132299248 13.711 AFF4
AF4/FMR2 family, member 4
chr12_-_122751044 13.547 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr11_-_113746205 13.365 NM_020886
USP28
ubiquitin specific peptidase 28
chr3_-_57583153 13.316 NM_001660
ARF4
ADP-ribosylation factor 4
chr12_-_122750954 12.986 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr13_+_113951589 12.932 LAMP1
lysosomal-associated membrane protein 1
chr2_-_172967627 12.753 DLX2
distal-less homeobox 2
chr19_+_50031232 12.284 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr17_-_7197896 12.073 YBX2
Y box binding protein 2
chr8_-_95274540 11.915 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr5_+_94890777 11.820 NM_198150
ARSK
arylsulfatase family, member K
chr8_-_95274520 11.731 GEM
GTP binding protein overexpressed in skeletal muscle
chr17_-_7197811 11.699 YBX2
Y box binding protein 2
chr1_-_154193044 11.620 C1orf43
chromosome 1 open reading frame 43
chr19_-_5340700 11.436 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr5_-_95297597 11.400 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr7_-_19157262 11.379 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr12_-_112450914 11.204 NM_001193453
NM_001193531
NM_138341
LOC728543
TMEM116


uncharacterized LOC728543
transmembrane protein 116


chr3_-_57583090 11.193 ARF4
ADP-ribosylation factor 4
chr3_-_73673978 11.067 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr12_-_53448167 11.014 LOC283335
uncharacterized LOC283335
chr2_-_242254984 10.842 HDLBP
high density lipoprotein binding protein
chr17_-_7197866 10.796 NM_015982
YBX2
Y box binding protein 2
chr19_+_47759802 10.682 CCDC9
coiled-coil domain containing 9
chr14_+_68086633 10.621 ARG2
arginase, type II
chr2_-_242255114 10.575 NM_005336
HDLBP
high density lipoprotein binding protein
chr15_-_72668184 10.534 HEXA
hexosaminidase A (alpha polypeptide)
chr13_-_36920396 10.510 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr7_-_37956377 10.505 SFRP4
secreted frizzled-related protein 4
chr11_-_59383167 10.473 OSBP
oxysterol binding protein
chr20_+_30102261 10.404 HM13
histocompatibility (minor) 13
chr6_+_151561094 10.361 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr19_+_32836500 10.244 NM_001136156
NM_014910
ZNF507

zinc finger protein 507

chr19_+_47759730 10.111 NM_015603
CCDC9
coiled-coil domain containing 9
chr20_+_30102237 10.099 NM_030789
NM_178580
NM_178581
NM_178582
HM13



histocompatibility (minor) 13



chr7_-_129592794 10.098 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr3_-_197686837 9.935 NM_032263
IQCG
IQ motif containing G
chr5_+_102201713 9.913 PAM
peptidylglycine alpha-amidating monooxygenase
chr3_+_171757432 9.756 FNDC3B
fibronectin type III domain containing 3B
chr8_+_26240522 9.756 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr9_-_127533397 9.471 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr2_-_216300444 9.364 FN1
fibronectin 1
chr9_+_131709970 9.237 NM_015354
NUP188
nucleoporin 188kDa
chr19_+_16187266 9.230 TPM4
tropomyosin 4
chr12_-_106641675 9.230 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr6_+_30294224 9.205


chr1_+_113498984 9.160 LOC100506392
uncharacterized LOC100506392
chr9_+_6757636 8.889 NM_001146694
NM_001146695
NM_015061
KDM4C


lysine (K)-specific demethylase 4C


chr4_-_119757183 8.860 SEC24D
SEC24 family, member D (S. cerevisiae)
chr7_-_37956515 8.838 NM_003014
SFRP4
secreted frizzled-related protein 4
chr3_-_8543327 8.831 LOC100288428
uncharacterized LOC100288428
chr19_+_49866986 8.824 NM_001197302
NM_001197301
NM_014419
DKKL1


dickkopf-like 1


chr11_-_59383616 8.764 NM_002556
OSBP
oxysterol binding protein
chr7_-_129592711 8.731 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr12_+_112451229 8.723


chr3_-_57582866 8.704 ARF4
ADP-ribosylation factor 4
chr13_-_45915277 8.686 NM_003295
TPT1
tumor protein, translationally-controlled 1
chr14_-_45431121 8.659 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr9_+_131709991 8.626 NUP188
nucleoporin 188kDa
chr7_-_8301767 8.465 NM_001136020
ICA1
islet cell autoantigen 1, 69kDa
chr16_-_79634610 8.452 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr4_+_166299942 8.396 NM_001873
CPE
carboxypeptidase E
chrX_+_16804531 8.352 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr22_+_38597938 8.325 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr15_-_50978983 8.302 NM_017672
TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr8_+_133787556 8.290 NM_016018
NM_032205
NM_198513
PHF20L1


PHD finger protein 20-like 1


chr3_-_20227618 8.208 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
NM_001199251
NM_001199252
NM_001199253
NM_001199254
NM_001199255
NM_001199256
NM_001199257
SGOL1












shugoshin-like 1 (S. pombe)












chr13_-_45915308 8.181 TPT1
tumor protein, translationally-controlled 1
chr6_+_101846668 8.145 GRIK2
glutamate receptor, ionotropic, kainate 2
chr3_-_57583080 8.123 ARF4
ADP-ribosylation factor 4
chr1_+_154193294 8.122 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr1_-_47184790 8.091


chr1_+_36689996 8.016 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr13_+_113951461 8.003 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr1_+_37940074 7.942 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr18_+_9708269 7.939 RAB31
RAB31, member RAS oncogene family
chr2_-_176866925 7.923 NM_030650
KIAA1715
KIAA1715
chr19_+_5681016 7.914 NM_198704
NM_198705
NM_198533
NM_198707
NM_198706
NM_198708
HSD11B1L





hydroxysteroid (11-beta) dehydrogenase 1-like





chr11_+_113930430 7.904 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr18_+_23806385 7.850 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr14_+_101292451 7.812 MEG3
maternally expressed 3 (non-protein coding)
chr17_+_7211260 7.812 NM_001143761
EIF5A
eukaryotic translation initiation factor 5A
chr3_+_122785855 7.792 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr14_+_68086570 7.788 NM_001172
ARG2
arginase, type II
chr10_-_128077062 7.773 ADAM12
ADAM metallopeptidase domain 12
chr11_+_113930296 7.744 ZBTB16
zinc finger and BTB domain containing 16
chr4_-_119757288 7.743 NM_014822
SEC24D
SEC24 family, member D (S. cerevisiae)
chr2_-_20251788 7.731 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr22_+_38864015 7.714 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr14_-_93799360 7.712 BTBD7
BTB (POZ) domain containing 7
chr16_-_75498582 7.598 NM_145254
TMEM170A
transmembrane protein 170A
chr17_-_19880991 7.567 NM_007202
AKAP10
A kinase (PRKA) anchor protein 10
chr14_+_74486049 7.564 NM_025057
C14orf45
chromosome 14 open reading frame 45
chrX_-_47509993 7.511 NM_001114123
NM_005229
ELK1

ELK1, member of ETS oncogene family

chr16_+_68057144 7.507 NM_017803
DUS2L
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr3_-_119182423 7.440 NM_018266
TMEM39A
transmembrane protein 39A
chr8_+_104427590 7.413 DCAF13
DDB1 and CUL4 associated factor 13
chr6_+_127587984 7.398 RNF146
ring finger protein 146
chr10_-_101769640 7.397 NM_015221
DNMBP
dynamin binding protein
chr16_-_31470582 7.366


chr5_+_68389775 7.365 NM_001251969
NM_022902
NM_024055
SLC30A5


solute carrier family 30 (zinc transporter), member 5


chr2_+_79347610 7.360 REG1A
regenerating islet-derived 1 alpha
chr21_+_47545896 7.357 COL6A2
collagen, type VI, alpha 2
chr9_-_130477918 7.346 NM_001002913
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr7_-_8301681 7.295 NM_022307
ICA1
islet cell autoantigen 1, 69kDa
chr2_-_220408264 7.288 NM_024536
CHPF
chondroitin polymerizing factor
chr1_+_160313172 7.285 NCSTN
nicastrin
chr19_+_16187315 7.282 TPM4
tropomyosin 4
chr17_+_7210929 7.280 EIF5A
eukaryotic translation initiation factor 5A
chrX_-_47509864 7.253 ELK1
ELK1, member of ETS oncogene family
chr17_+_79885567 7.249 LOC92659
uncharacterized LOC92659
chr3_+_129159089 7.237 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr10_+_35416384 7.237 NM_181571
NM_183060
CREM

cAMP responsive element modulator

chr12_-_14720790 7.230 NM_024829
PLBD1
phospholipase B domain containing 1
chr4_-_186456580 7.230 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr18_+_9708299 7.215 RAB31
RAB31, member RAS oncogene family
chr14_-_81687265 7.206 NM_015859
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr13_-_45915203 7.163 TPT1
tumor protein, translationally-controlled 1
chr8_+_128806720 7.131 PVT1
Pvt1 oncogene (non-protein coding)
chr3_+_129159138 7.113 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr3_+_129159150 7.087 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr5_+_102201526 7.079 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr10_-_128077011 7.037 ADAM12
ADAM metallopeptidase domain 12
chr1_+_160313061 7.009 NM_015331
NCSTN
nicastrin
chr7_-_73184535 6.975 NM_001306
CLDN3
claudin 3
chr6_+_31982538 6.899 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr11_-_35547144 6.873 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr9_+_6757919 6.866 KDM4C
lysine (K)-specific demethylase 4C
chr3_+_129159075 6.863 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chrX_+_100805415 6.818 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr3_-_139108486 6.779


chr10_+_22634373 6.756 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr12_+_28343390 6.756


chr1_+_36690038 6.731 THRAP3
thyroid hormone receptor associated protein 3
chr3_+_129158949 6.721 NM_018262
NM_052985
NM_052989
NM_052990
IFT122



intraflagellar transport 122 homolog (Chlamydomonas)



chr7_+_116593354 6.701 NM_018412
NM_021908
ST7

suppression of tumorigenicity 7

chr6_-_70506472 6.680 LMBRD1
LMBR1 domain containing 1
chr7_+_128470462 6.671 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr19_+_18794487 6.656 CRTC1
CREB regulated transcription coactivator 1
chr14_+_101292483 6.630


chr4_-_54930706 6.629 CHIC2
cysteine-rich hydrophobic domain 2
chr12_+_56552141 6.606 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr13_-_95364248 6.572 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr7_+_99775346 6.566 STAG3
stromal antigen 3
chr17_-_13505217 6.562 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr10_+_121411071 6.554 BAG3
BCL2-associated athanogene 3
chr11_-_119234859 6.551 NM_171997
USP2
ubiquitin specific peptidase 2
chr10_+_121410751 6.516 NM_004281
BAG3
BCL2-associated athanogene 3
chr16_-_1525006 6.505 CLCN7
chloride channel 7
chr1_-_35497249 6.493 ZMYM6
zinc finger, MYM-type 6
chr1_-_31712733 6.460 NM_024522
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr12_-_14720553 6.450 PLBD1
phospholipase B domain containing 1
chr2_-_211035913 6.409 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr14_-_64970319 6.396 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr10_+_121411042 6.388 BAG3
BCL2-associated athanogene 3
chr10_+_121410891 6.386 BAG3
BCL2-associated athanogene 3
chr1_-_235812994 6.363 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr2_-_1748285 6.343 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr8_+_104427637 6.324 DCAF13
DDB1 and CUL4 associated factor 13
chr7_+_44646180 6.299 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr17_-_46687925 6.295 HOXB7
homeobox B7
chr11_-_62598552 6.273 STX5
syntaxin 5
chr2_+_236402948 6.263 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr3_+_142442855 6.245


chr1_+_37940129 6.232 ZC3H12A
zinc finger CCCH-type containing 12A
chr14_-_74485813 6.198 NM_001249
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
chr7_-_72992888 6.193 TBL2
transducin (beta)-like 2
chr14_+_23305913 6.146 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr19_-_4457789 6.137 NM_025241
UBXN6
UBX domain protein 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 3.02e-13 GO:0043170 macromolecule metabolic process
2.27 1.51e-12 GO:0006351 transcription, DNA-dependent
2.16 7.93e-12 GO:0032774 RNA biosynthetic process
1.44 4.69e-11 GO:0044260 cellular macromolecule metabolic process
1.18 4.82e-11 GO:0009987 cellular process
1.26 2.64e-09 GO:0065007 biological regulation
1.47 3.53e-09 GO:0031323 regulation of cellular metabolic process
1.70 6.50e-09 GO:0010467 gene expression
1.61 9.44e-09 GO:0051252 regulation of RNA metabolic process
1.62 1.16e-08 GO:0006355 regulation of transcription, DNA-dependent
1.54 1.49e-08 GO:0009889 regulation of biosynthetic process
1.55 1.52e-08 GO:0031326 regulation of cellular biosynthetic process
1.42 2.40e-08 GO:0019222 regulation of metabolic process
1.27 2.98e-08 GO:0050794 regulation of cellular process
1.57 3.52e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.52 5.50e-08 GO:0051171 regulation of nitrogen compound metabolic process
1.26 6.35e-08 GO:0050789 regulation of biological process
1.55 7.21e-08 GO:0010556 regulation of macromolecule biosynthetic process
1.44 7.91e-08 GO:0080090 regulation of primary metabolic process
1.53 8.31e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 1.06e-07 GO:0044238 primary metabolic process
1.29 1.14e-07 GO:0044237 cellular metabolic process
1.26 1.23e-07 GO:0008152 metabolic process
1.53 2.06e-07 GO:0010468 regulation of gene expression
1.73 2.68e-07 GO:0009653 anatomical structure morphogenesis
1.44 3.17e-07 GO:0060255 regulation of macromolecule metabolic process
1.67 3.41e-07 GO:0009059 macromolecule biosynthetic process
1.66 3.54e-07 GO:0016070 RNA metabolic process
1.66 9.50e-07 GO:0034645 cellular macromolecule biosynthetic process
1.87 2.87e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.38 5.24e-06 GO:0032502 developmental process
2.53 2.19e-05 GO:0001501 skeletal system development
1.52 2.19e-05 GO:0048523 negative regulation of cellular process
2.05 4.42e-05 GO:0009887 organ morphogenesis
1.50 4.71e-05 GO:0090304 nucleic acid metabolic process
1.67 7.31e-05 GO:0051641 cellular localization
1.43 7.34e-05 GO:0048518 positive regulation of biological process
1.74 8.61e-05 GO:0008104 protein localization
1.46 1.21e-04 GO:0048519 negative regulation of biological process
1.38 2.00e-04 GO:0048856 anatomical structure development
1.97 2.08e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.63 2.94e-04 GO:0033036 macromolecule localization
1.44 3.11e-04 GO:0044249 cellular biosynthetic process
1.76 4.75e-04 GO:0050793 regulation of developmental process
1.42 8.24e-04 GO:0048522 positive regulation of cellular process
1.86 1.04e-03 GO:0009790 embryo development
1.41 1.09e-03 GO:0009058 biosynthetic process
1.98 1.11e-03 GO:0051253 negative regulation of RNA metabolic process
1.89 1.12e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.86 1.18e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.99 1.25e-03 GO:0045892 negative regulation of transcription, DNA-dependent
2.91 1.29e-03 GO:0009952 anterior/posterior pattern formation
1.36 1.52e-03 GO:0019538 protein metabolic process
1.48 1.75e-03 GO:0006464 protein modification process
1.72 1.77e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.34 1.96e-03 GO:0006807 nitrogen compound metabolic process
1.72 2.13e-03 GO:0031324 negative regulation of cellular metabolic process
4.37 2.36e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.65 2.42e-03 GO:0010941 regulation of cell death
1.83 2.54e-03 GO:0009890 negative regulation of biosynthetic process
1.79 2.64e-03 GO:2000026 regulation of multicellular organismal development
3.02 2.77e-03 GO:0016055 Wnt receptor signaling pathway
1.89 2.85e-03 GO:0010629 negative regulation of gene expression
3.87 2.97e-03 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
1.46 3.18e-03 GO:0048513 organ development
2.08 3.21e-03 GO:0007243 intracellular protein kinase cascade
2.08 3.21e-03 GO:0023014 signal transduction via phosphorylation event
1.72 3.67e-03 GO:0015031 protein transport
2.00 3.73e-03 GO:0072358 cardiovascular system development
2.00 3.73e-03 GO:0072359 circulatory system development
1.64 4.01e-03 GO:0043067 regulation of programmed cell death
2.14 4.05e-03 GO:0048598 embryonic morphogenesis
2.01 4.17e-03 GO:0048646 anatomical structure formation involved in morphogenesis
2.10 4.22e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.95 4.54e-03 GO:0034613 cellular protein localization
1.86 4.64e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.71 4.71e-03 GO:0009888 tissue development
1.31 4.80e-03 GO:0007275 multicellular organismal development
1.33 5.11e-03 GO:0034641 cellular nitrogen compound metabolic process
2.29 5.49e-03 GO:0001944 vasculature development
1.36 5.50e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.94 5.53e-03 GO:0070727 cellular macromolecule localization
3.85 6.46e-03 GO:0034130 toll-like receptor 1 signaling pathway
3.85 6.46e-03 GO:0034134 toll-like receptor 2 signaling pathway
1.65 6.64e-03 GO:0009892 negative regulation of metabolic process
1.84 7.02e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.38 7.14e-03 GO:0044267 cellular protein metabolic process
1.69 7.35e-03 GO:0045184 establishment of protein localization
1.43 8.57e-03 GO:0043412 macromolecule modification
1.62 9.03e-03 GO:0042981 regulation of apoptosis
3.95 9.30e-03 GO:0034138 toll-like receptor 3 signaling pathway
1.34 9.37e-03 GO:0048731 system development
1.59 9.90e-03 GO:0051649 establishment of localization in cell
2.36 1.00e-02 GO:0000165 MAPKKK cascade
1.54 1.36e-02 GO:0051239 regulation of multicellular organismal process
3.83 1.41e-02 GO:0002756 MyD88-independent toll-like receptor signaling pathway
2.27 1.79e-02 GO:0001568 blood vessel development
1.96 2.11e-02 GO:0032583 regulation of gene-specific transcription
1.71 2.33e-02 GO:0016192 vesicle-mediated transport
3.50 2.45e-02 GO:0008063 Toll signaling pathway
3.50 2.45e-02 GO:0034142 toll-like receptor 4 signaling pathway
2.68 2.48e-02 GO:0048562 embryonic organ morphogenesis
3.32 2.70e-02 GO:0002224 toll-like receptor signaling pathway
6.64 2.81e-02 GO:0048199 vesicle targeting, to, from or within Golgi
1.50 3.00e-02 GO:0035556 intracellular signal transduction
1.27 3.21e-02 GO:0023052 signaling
2.36 3.82e-02 GO:0048514 blood vessel morphogenesis
2.18 4.18e-02 GO:0035295 tube development
2.05 4.45e-02 GO:0007389 pattern specification process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 9.68e-14 GO:0043227 membrane-bounded organelle
1.26 1.24e-13 GO:0043231 intracellular membrane-bounded organelle
1.18 2.10e-13 GO:0044424 intracellular part
1.17 7.30e-12 GO:0005622 intracellular
1.20 9.11e-11 GO:0043226 organelle
1.20 9.42e-11 GO:0043229 intracellular organelle
1.31 2.45e-08 GO:0005634 nucleus
1.19 2.13e-06 GO:0005737 cytoplasm
1.24 7.22e-05 GO:0044422 organelle part
1.23 2.21e-04 GO:0044446 intracellular organelle part
1.65 5.02e-04 GO:0005794 Golgi apparatus
1.21 5.04e-04 GO:0044444 cytoplasmic part
1.60 9.93e-04 GO:0005783 endoplasmic reticulum
1.37 2.78e-03 GO:0043233 organelle lumen
1.80 2.91e-03 GO:0044431 Golgi apparatus part
1.36 3.29e-03 GO:0031974 membrane-enclosed lumen
1.45 3.67e-03 GO:0012505 endomembrane system
1.68 6.86e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.67 6.91e-03 GO:0031988 membrane-bounded vesicle
3.02 8.51e-03 GO:0005788 endoplasmic reticulum lumen
1.35 9.53e-03 GO:0070013 intracellular organelle lumen
1.83 1.06e-02 GO:0000139 Golgi membrane
1.39 1.13e-02 GO:0031981 nuclear lumen
1.62 1.50e-02 GO:0031410 cytoplasmic vesicle
1.46 1.59e-02 GO:0005654 nucleoplasm
3.76 2.11e-02 GO:0005793 ER-Golgi intermediate compartment
1.59 2.40e-02 GO:0031982 vesicle
1.34 2.42e-02 GO:0031090 organelle membrane
1.61 2.55e-02 GO:0044432 endoplasmic reticulum part
2.99 2.74e-02 GO:0042470 melanosome
2.99 2.74e-02 GO:0048770 pigment granule
1.33 3.68e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.25 1.81e-15 GO:0001071 nucleic acid binding transcription factor activity
2.25 1.81e-15 GO:0003700 sequence-specific DNA binding transcription factor activity
2.35 1.01e-11 GO:0043565 sequence-specific DNA binding
1.28 1.26e-10 GO:0005515 protein binding
1.90 3.01e-08 GO:0030528 transcription regulator activity
1.13 6.31e-07 GO:0005488 binding
1.46 1.25e-05 GO:0003677 DNA binding
2.23 7.02e-05 GO:0000988 protein binding transcription factor activity
2.23 7.02e-05 GO:0000989 transcription factor binding transcription factor activity
2.19 1.62e-04 GO:0003712 transcription cofactor activity
4.23 4.13e-03 GO:0003707 steroid hormone receptor activity
2.38 7.12e-03 GO:0000975 regulatory region DNA binding
2.38 7.12e-03 GO:0001067 regulatory region nucleic acid binding
2.38 7.12e-03 GO:0044212 transcription regulatory region DNA binding
4.00 8.12e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.03 3.16e-02 GO:0008134 transcription factor binding
1.26 4.92e-02 GO:0003676 nucleic acid binding