Motif ID: BACH2.p2

Z-value: 2.053


Transcription factors associated with BACH2.p2:

Gene SymbolEntrez IDGene Name
BACH2 60468 BTB and CNC homology 1, basic leucine zipper transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
BACH2chr6_-_91006580-0.421.4e-10Click!


Activity profile for motif BACH2.p2.

activity profile for motif BACH2.p2


Sorted Z-values histogram for motif BACH2.p2

Sorted Z-values for motif BACH2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_223889253 129.570 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr17_+_30771520 96.747 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_31704070 78.399 CLIC1
chloride intracellular channel 1
chr1_-_152009440 76.015 S100A11
S100 calcium binding protein A11
chr1_-_152009406 73.956 S100A11
S100 calcium binding protein A11
chr6_-_31704318 73.616 NM_001288
CLIC1
chloride intracellular channel 1
chr6_-_31704304 73.044 CLIC1
chloride intracellular channel 1
chr6_-_31704272 72.090 CLIC1
chloride intracellular channel 1
chr6_-_31704281 72.001 CLIC1
chloride intracellular channel 1
chr6_-_31704287 71.843 CLIC1
chloride intracellular channel 1
chr6_-_31704093 71.027 CLIC1
chloride intracellular channel 1
chr11_-_2950593 63.965 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr1_+_156084541 63.865 LMNA
lamin A/C
chr7_-_96339074 56.889 SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr17_+_30771532 56.419 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr7_-_7758237 55.551 NM_002947
RPA3
replication protein A3, 14kDa
chr17_+_30771494 55.160 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485 54.503 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771522 51.242 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_26606621 49.586 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr11_-_65667858 49.447 FOSL1
FOS-like antigen 1
chr1_+_156084565 49.162 LMNA
lamin A/C
chr3_+_183894736 48.266 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr1_+_223900226 48.123 CAPN2
calpain 2, (m/II) large subunit
chr15_+_22892683 47.425 NM_014608
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr17_-_73150769 47.069 NM_001002032
NM_001002033
NM_016185
HN1


hematological and neurological expressed 1


chr1_+_26606586 46.629 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr11_-_65667809 46.415 FOSL1
FOS-like antigen 1
chr1_-_152009490 45.059 NM_005620
S100A11
S100 calcium binding protein A11
chr15_+_22892714 44.335 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr15_+_22892723 44.083 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr12_-_53343607 44.000 KRT8
keratin 8
chr1_-_109969058 42.957 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr20_-_52199635 42.837 NM_006526
ZNF217
zinc finger protein 217
chr1_+_223900061 42.796 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr2_-_85641128 42.203 CAPG
capping protein (actin filament), gelsolin-like
chr1_+_156084579 41.610 LMNA
lamin A/C
chr1_+_156084458 41.153 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr16_+_30077120 40.566 ALDOA
aldolase A, fructose-bisphosphate
chr16_+_30076993 40.440 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr15_+_22892517 40.199 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr15_-_60690115 40.096 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr8_+_26150731 39.603 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr16_+_30077146 39.227 ALDOA
aldolase A, fructose-bisphosphate
chr1_-_225616556 38.681 NM_194442
LBR
lamin B receptor
chr19_+_36630846 38.203 NM_001003962
NM_001749
CAPNS1

calpain, small subunit 1

chr19_+_36630999 37.633 CAPNS1
calpain, small subunit 1
chr1_-_246580710 36.713 NM_022743
SMYD3
SET and MYND domain containing 3
chr19_+_36631001 35.698 CAPNS1
calpain, small subunit 1
chr1_-_109969044 35.579 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr6_-_38670904 34.909 GLO1
glyoxalase I
chr6_-_38670915 34.895 GLO1
glyoxalase I
chr6_-_38670871 34.126 GLO1
glyoxalase I
chr6_-_38670922 33.873 NM_006708
GLO1
glyoxalase I
chr6_-_38670882 33.747 GLO1
glyoxalase I
chr6_-_38670829 32.575 GLO1
glyoxalase I
chr22_-_43343046 32.565 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr14_+_103801160 32.451 NM_183004
EIF5
eukaryotic translation initiation factor 5
chr5_+_73981055 32.019 HEXB
hexosaminidase B (beta polypeptide)
chr7_-_96339171 31.691 NM_006304
SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr1_-_84972259 31.624 NM_005274
GNG5
guanine nucleotide binding protein (G protein), gamma 5
chr5_+_159436143 31.112 TTC1
tetratricopeptide repeat domain 1
chr11_+_67351065 31.110 NM_000852
GSTP1
glutathione S-transferase pi 1
chr6_+_44195008 30.921 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr15_+_22892699 29.446 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr5_+_138089073 29.309 NM_001903
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr1_-_24126031 29.301 NM_001127621
GALE
UDP-galactose-4-epimerase
chr6_-_159239254 29.215 EZR
ezrin
chr12_-_76478347 29.160 NAP1L1
nucleosome assembly protein 1-like 1
chr17_+_30677178 28.835 ZNF207
zinc finger protein 207
chr5_+_72143993 28.807 TNPO1
transportin 1
chr14_-_23426356 28.745 HAUS4
HAUS augmin-like complex, subunit 4
chr3_-_49395697 28.120 GPX1
glutathione peroxidase 1
chr1_-_109968951 28.005 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr1_+_223900212 27.477 CAPN2
calpain 2, (m/II) large subunit
chr7_-_99006215 27.399 PDAP1
PDGFA associated protein 1
chr17_+_30677138 27.381 NM_001032293
NM_001098507
NM_003457
ZNF207


zinc finger protein 207


chr6_-_159239198 27.309 EZR
ezrin
chr6_-_159239269 27.134 NM_003379
EZR
ezrin
chr7_-_99006170 27.125 PDAP1
PDGFA associated protein 1
chr11_-_65667860 27.022 NM_005438
FOSL1
FOS-like antigen 1
chr1_-_209824641 26.942 NM_001017402
LAMB3
laminin, beta 3
chr17_+_18625335 26.903 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr1_-_27816676 26.769 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr5_+_138089118 26.759 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chrX_-_15511710 26.404 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr5_+_72143929 26.348 NM_153188
TNPO1
transportin 1
chrX_-_15511358 26.287 PIR
pirin (iron-binding nuclear protein)
chr16_-_12010518 26.157 NM_001130007
GSPT1
G1 to S phase transition 1
chr5_+_73980968 26.121 NM_000521
HEXB
hexosaminidase B (beta polypeptide)
chr1_-_154943001 25.999 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr10_+_121410751 25.464 NM_004281
BAG3
BCL2-associated athanogene 3
chr3_+_184016985 25.377 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr11_+_101983170 25.356 NM_001195045
YAP1
Yes-associated protein 1
chr17_+_30677187 25.314 ZNF207
zinc finger protein 207
chr4_-_74088773 25.226 ANKRD17
ankyrin repeat domain 17
chr1_-_84971848 25.140 GNG5
guanine nucleotide binding protein (G protein), gamma 5
chr10_+_121411042 25.040 BAG3
BCL2-associated athanogene 3
chr22_+_39378404 24.758 NM_004900
APOBEC3D
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chr13_+_28196004 24.689 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr19_+_49376488 24.477 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr11_+_18415917 24.258 NM_001135239
NM_001165415
NM_001165416
NM_005566
LDHA



lactate dehydrogenase A



chr2_-_85641153 24.239 CAPG
capping protein (actin filament), gelsolin-like
chr2_+_47596286 24.054 NM_002354
EPCAM
epithelial cell adhesion molecule
chr12_-_76478410 23.997 NAP1L1
nucleosome assembly protein 1-like 1
chr7_+_116312412 23.687 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chrX_-_129244471 23.660 NM_001421
ELF4
E74-like factor 4 (ets domain transcription factor)
chr9_+_71819926 23.499 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr17_-_76921453 23.460 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_+_169940223 23.370 PRKCI
protein kinase C, iota
chr3_+_184017038 23.237 PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr14_-_75643309 22.910 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_+_47596447 22.905 EPCAM
epithelial cell adhesion molecule
chr10_+_17270257 22.874 NM_003380
VIM
vimentin
chr10_+_17270469 22.718 VIM
vimentin
chr3_-_49395751 22.682 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr6_+_106959729 22.561 NM_001624
AIM1
absent in melanoma 1
chr14_-_23426265 22.544 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chrX_-_129272014 22.505 NM_001130846
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr12_-_76478737 22.480 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr17_+_80193649 22.419 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr13_+_28195913 22.216 NM_015972
NM_152705
POLR1D

polymerase (RNA) I polypeptide D, 16kDa

chr21_-_46237978 22.111 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr16_+_89988416 22.110 NM_001197181
TUBB3
tubulin, beta 3 class III
chr3_+_187930720 22.021 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_152009467 22.014 S100A11
S100 calcium binding protein A11
chr17_-_65362635 21.889 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr10_+_85899184 21.680 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr17_-_65362667 21.435 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr5_+_70944968 21.417 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr2_+_27851514 21.213 NM_001145047
NM_001145048
NM_001145049
GPN1


GPN-loop GTPase 1


chr10_+_121411086 21.201 BAG3
BCL2-associated athanogene 3
chr17_+_79651035 21.138 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr3_+_184038050 20.863 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr17_+_79650961 20.852 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr5_-_137911039 20.791 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr11_-_33744497 20.729 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr10_-_13342036 20.720 PHYH
phytanoyl-CoA 2-hydroxylase
chr10_+_88854900 20.711 NM_019054
FAM35A
family with sequence similarity 35, member A
chr17_-_18161869 20.669 FLII
flightless I homolog (Drosophila)
chr14_-_75643286 20.645 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr12_-_56122840 20.419 NM_001040034
NM_001780
CD63

CD63 molecule

chr7_+_48128225 20.200 NM_181597
UPP1
uridine phosphorylase 1
chr17_+_7123246 20.156 ACADVL
acyl-CoA dehydrogenase, very long chain
chr7_+_143078358 19.937 NM_001010972
NM_003461
ZYX

zyxin

chr17_+_79651072 19.815 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr8_-_59572385 19.716 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr20_+_35807430 19.466 NM_001135771
NM_002951
RPN2

ribophorin II

chr11_+_2924504 19.328 SLC22A18
solute carrier family 22, member 18
chr1_-_153935190 19.282 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr6_+_138725314 19.190 NM_014320
HEBP2
heme binding protein 2
chr17_+_79651042 19.088 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr2_+_207630310 18.946 FASTKD2
FAST kinase domains 2
chr1_+_154947147 18.925 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr4_+_74606222 18.709 NM_000584
IL8
interleukin 8
chr8_-_59571920 18.575 NM_001144772
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr12_-_56122800 18.417 CD63
CD63 molecule
chr6_-_84140758 18.221 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr10_+_121411071 18.097 BAG3
BCL2-associated athanogene 3
chr3_+_69134057 18.097 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr1_+_36621751 18.089 NM_018067
MAP7D1
MAP7 domain containing 1
chr7_+_143078457 18.086 ZYX
zyxin
chr12_-_56122792 18.056 CD63
CD63 molecule
chr2_-_65593866 17.900 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr9_+_140135698 17.777 NM_006088
TUBB4B
tubulin, beta 4B class IVb
chr6_-_138428477 17.747 NM_022121
PERP
PERP, TP53 apoptosis effector
chr3_+_169940246 17.718 PRKCI
protein kinase C, iota
chr8_-_59572403 17.697 NM_003580
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr5_+_179247911 17.627 SQSTM1
sequestosome 1
chr17_-_18162018 17.454 FLII
flightless I homolog (Drosophila)
chr5_-_137911005 17.358 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr1_-_45987548 17.348 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr7_+_143078395 17.293 ZYX
zyxin
chr10_+_121410891 17.282 BAG3
BCL2-associated athanogene 3
chr1_+_36621457 17.266 MAP7D1
MAP7 domain containing 1
chr14_-_75643333 17.212 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr16_+_74330660 17.194 NM_002811
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr17_+_28707495 17.162 NM_001199775
CPD
carboxypeptidase D
chr21_+_33031932 17.047 NM_000454
SOD1
superoxide dismutase 1, soluble
chr14_+_103800678 16.971 EIF5
eukaryotic translation initiation factor 5
chr7_+_143078447 16.787 ZYX
zyxin
chr14_-_75643335 16.710 NM_006827
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chrX_-_129244652 16.669 NM_001127197
ELF4
E74-like factor 4 (ets domain transcription factor)
chr6_-_84140744 16.562 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr18_+_55888799 16.386 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_55888838 16.328 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_-_7590731 16.312 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr15_+_89631380 16.243 NM_007011
NM_152924
ABHD2

abhydrolase domain containing 2

chr13_+_28196024 16.241 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr1_-_108231122 16.073 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr13_+_28196029 16.008 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr16_+_57662301 15.998 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr6_+_64231626 15.937 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_201997687 15.833 NM_001202518
CFLAR
CASP8 and FADD-like apoptosis regulator
chr15_+_44829300 15.789 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr5_-_175843531 15.642 NM_001834
NM_007097
CLTB

clathrin, light chain B

chr17_+_7123149 15.618 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr17_+_49230929 15.558 NME1
non-metastatic cells 1, protein (NM23A) expressed in
chr7_+_143078444 15.495 ZYX
zyxin
chr14_-_94855120 15.440 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 7.68e-14 GO:0009987 cellular process
2.63 1.24e-09 GO:0043067 regulation of programmed cell death
2.59 2.52e-09 GO:0010941 regulation of cell death
2.61 2.60e-09 GO:0042981 regulation of apoptosis
1.46 1.86e-08 GO:0044237 cellular metabolic process
1.39 1.68e-07 GO:0008152 metabolic process
2.72 8.69e-07 GO:0012501 programmed cell death
1.38 1.59e-06 GO:0050794 regulation of cellular process
1.40 1.60e-06 GO:0044238 primary metabolic process
2.70 1.65e-06 GO:0006915 apoptosis
2.30 3.21e-06 GO:0051246 regulation of protein metabolic process
1.33 3.89e-06 GO:0065007 biological regulation
2.88 5.99e-06 GO:0050878 regulation of body fluid levels
2.43 1.09e-05 GO:0008219 cell death
1.34 1.12e-05 GO:0050789 regulation of biological process
1.76 1.14e-05 GO:0048522 positive regulation of cellular process
2.42 1.28e-05 GO:0016265 death
1.63 1.61e-05 GO:0034641 cellular nitrogen compound metabolic process
8.61 1.68e-05 GO:0006521 regulation of cellular amino acid metabolic process
1.62 1.70e-05 GO:0006807 nitrogen compound metabolic process
1.69 2.16e-05 GO:0048518 positive regulation of biological process
2.29 3.95e-05 GO:0042127 regulation of cell proliferation
4.93 4.52e-05 GO:0000082 G1/S transition of mitotic cell cycle
1.73 7.20e-05 GO:0048519 negative regulation of biological process
3.46 7.32e-05 GO:0031401 positive regulation of protein modification process
2.12 8.60e-05 GO:0044248 cellular catabolic process
7.48 9.05e-05 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
7.48 9.05e-05 GO:0072395 signal transduction involved in cell cycle checkpoint
7.48 9.05e-05 GO:0072401 signal transduction involved in DNA integrity checkpoint
7.48 9.05e-05 GO:0072404 signal transduction involved in G1/S transition checkpoint
7.48 9.05e-05 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
7.48 9.05e-05 GO:0072422 signal transduction involved in DNA damage checkpoint
7.48 9.05e-05 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
7.48 9.05e-05 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.29 9.67e-05 GO:0009611 response to wounding
1.97 1.03e-04 GO:0009056 catabolic process
2.20 1.08e-04 GO:0032268 regulation of cellular protein metabolic process
1.70 1.42e-04 GO:0006950 response to stress
7.13 1.59e-04 GO:0033238 regulation of cellular amine metabolic process
7.13 1.59e-04 GO:0071158 positive regulation of cell cycle arrest
2.20 1.75e-04 GO:0032879 regulation of localization
2.80 1.96e-04 GO:0007596 blood coagulation
2.80 1.96e-04 GO:0050817 coagulation
1.64 1.99e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
6.34 1.99e-04 GO:0000216 M/G1 transition of mitotic cell cycle
2.78 2.29e-04 GO:0007599 hemostasis
5.28 2.60e-04 GO:0000084 S phase of mitotic cell cycle
6.71 3.20e-04 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
5.19 3.33e-04 GO:0051320 S phase
3.00 4.43e-04 GO:0032270 positive regulation of cellular protein metabolic process
2.56 4.57e-04 GO:0042060 wound healing
6.43 5.24e-04 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.46 6.10e-04 GO:0051716 cellular response to stimulus
3.38 6.79e-04 GO:0010035 response to inorganic substance
2.00 9.38e-04 GO:0050790 regulation of catalytic activity
1.70 9.63e-04 GO:0048523 negative regulation of cellular process
2.87 1.14e-03 GO:0051247 positive regulation of protein metabolic process
5.93 1.30e-03 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.34 1.41e-03 GO:0043085 positive regulation of catalytic activity
5.85 1.51e-03 GO:0031575 mitotic cell cycle G1/S transition checkpoint
5.85 1.51e-03 GO:0051443 positive regulation of ubiquitin-protein ligase activity
5.85 1.51e-03 GO:0071779 G1/S transition checkpoint
4.93 1.60e-03 GO:0031398 positive regulation of protein ubiquitination
2.21 1.72e-03 GO:0044093 positive regulation of molecular function
5.71 1.99e-03 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
1.42 2.17e-03 GO:0044260 cellular macromolecule metabolic process
6.25 2.22e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.38 2.27e-03 GO:0043170 macromolecule metabolic process
3.62 2.57e-03 GO:0006916 anti-apoptosis
5.57 2.61e-03 GO:0051351 positive regulation of ligase activity
5.57 2.61e-03 GO:2000045 regulation of G1/S transition of mitotic cell cycle
4.14 2.94e-03 GO:0046039 GTP metabolic process
2.12 3.10e-03 GO:0051704 multi-organism process
5.98 3.48e-03 GO:0051352 negative regulation of ligase activity
5.98 3.48e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.49 3.93e-03 GO:0007165 signal transduction
4.29 3.96e-03 GO:0010565 regulation of cellular ketone metabolic process
5.31 4.38e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.17 4.99e-03 GO:0031399 regulation of protein modification process
1.71 6.22e-03 GO:0044281 small molecule metabolic process
4.14 6.30e-03 GO:0006184 GTP catabolic process
5.07 7.14e-03 GO:0051438 regulation of ubiquitin-protein ligase activity
2.65 8.04e-03 GO:0008285 negative regulation of cell proliferation
4.62 8.19e-03 GO:0042770 signal transduction in response to DNA damage
1.44 8.81e-03 GO:0023052 signaling
2.98 9.78e-03 GO:0051329 interphase of mitotic cell cycle
4.86 1.13e-02 GO:0051340 regulation of ligase activity
1.50 1.15e-02 GO:0019538 protein metabolic process
3.94 1.16e-02 GO:0030335 positive regulation of cell migration
3.94 1.16e-02 GO:2000147 positive regulation of cell motility
3.15 1.17e-02 GO:0030334 regulation of cell migration
2.93 1.30e-02 GO:0051325 interphase
3.11 1.40e-02 GO:2000145 regulation of cell motility
1.77 1.61e-02 GO:0065009 regulation of molecular function
3.81 1.76e-02 GO:0040017 positive regulation of locomotion
1.29 1.80e-02 GO:0050896 response to stimulus
2.36 2.27e-02 GO:0044265 cellular macromolecule catabolic process
1.54 2.28e-02 GO:0044267 cellular protein metabolic process
3.71 2.42e-02 GO:0010498 proteasomal protein catabolic process
3.71 2.42e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.24 2.49e-02 GO:0009057 macromolecule catabolic process
3.68 2.62e-02 GO:0051272 positive regulation of cellular component movement
4.81 3.02e-02 GO:0031397 negative regulation of protein ubiquitination
2.22 3.20e-02 GO:0051726 regulation of cell cycle
4.35 3.57e-02 GO:0090068 positive regulation of cell cycle process
3.78 3.76e-02 GO:0031396 regulation of protein ubiquitination
4.31 3.93e-02 GO:0000077 DNA damage checkpoint
3.99 4.14e-02 GO:0007093 mitotic cell cycle checkpoint
5.07 4.55e-02 GO:0002576 platelet degranulation
1.82 4.82e-02 GO:0031325 positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 1.18e-14 GO:0005737 cytoplasm
1.24 1.95e-10 GO:0044424 intracellular part
1.22 2.59e-09 GO:0005622 intracellular
7.85 2.15e-06 GO:0000502 proteasome complex
1.34 1.01e-04 GO:0044444 cytoplasmic part
1.53 5.82e-04 GO:0043234 protein complex
1.22 9.91e-04 GO:0043227 membrane-bounded organelle
1.21 1.40e-03 GO:0043231 intracellular membrane-bounded organelle
1.18 4.05e-03 GO:0043226 organelle
1.18 5.24e-03 GO:0043229 intracellular organelle
1.39 1.43e-02 GO:0032991 macromolecular complex
16.91 1.51e-02 GO:0005838 proteasome regulatory particle
2.00 2.46e-02 GO:0031967 organelle envelope
1.96 3.48e-02 GO:0031975 envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.51 1.44e-16 GO:0005515 protein binding
1.18 1.92e-06 GO:0005488 binding
5.23 2.65e-03 GO:0070851 growth factor receptor binding
3.14 1.16e-02 GO:0003924 GTPase activity