Motif ID: CUX2.p2

Z-value: 0.843


Transcription factors associated with CUX2.p2:

Gene SymbolEntrez IDGene Name
CUX2 23316 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CUX2chr12_+_1114718270.236.6e-04Click!


Activity profile for motif CUX2.p2.

activity profile for motif CUX2.p2


Sorted Z-values histogram for motif CUX2.p2

Sorted Z-values for motif CUX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CUX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_198608136 39.073 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_198608216 36.880 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_198608244 33.317 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_-_89165652 31.721


chr13_-_46756295 31.668 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr13_-_46756291 16.889 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_+_36606456 14.662 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr7_+_80231503 13.899 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr5_+_36606667 12.460 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_116392099 11.569 ABLIM1
actin binding LIM protein 1
chr13_-_46756326 10.417 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_-_36764000 9.771 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr1_-_147610080 9.187 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr6_+_32709162 8.766 NM_020056
HLA-DQA1
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 2
chr1_-_146068244 8.273 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr1_+_117297056 7.675 NM_001767
CD2
CD2 molecule
chr2_+_202004997 7.554 NM_001202515
CFLAR
CASP8 and FADD-like apoptosis regulator
chr6_-_152958533 7.480 NM_182961
SYNE1
spectrin repeat containing, nuclear envelope 1
chr17_+_7461591 7.415 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr2_-_192016293 7.103 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr13_+_31309644 6.989 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr12_-_10562744 6.907 NM_001199805
KLRC4-KLRK1
KLRC4-KLRK1 readthrough
chr3_+_52811601 6.627 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr22_-_26961333 6.465 NM_001008566
TPST2
tyrosylprotein sulfotransferase 2
chr8_-_120651019 6.014 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr1_-_51887740 5.853 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr6_-_154677868 5.840 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chrX_+_123480131 5.790 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr1_+_111413820 4.508 NM_001040033
CD53
CD53 molecule
chr12_+_6554032 4.253 NM_001242
CD27
CD27 molecule
chr8_-_18541441 3.966 PSD3
pleckstrin and Sec7 domain containing 3
chr13_-_36429798 3.832 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr2_+_169926084 3.811 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_50571963 3.463 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr20_-_34241830 3.458 NM_003915
CPNE1
copine I
chr12_+_74931550 3.372 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr4_+_71587674 3.245 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr7_+_80275634 3.236 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr1_+_104159953 3.111 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr17_-_79875995 3.066 SIRT7
sirtuin 7
chr4_-_72649734 3.055 NM_000583
GC
group-specific component (vitamin D binding protein)
chr7_-_104909442 2.901 NM_182691
SRPK2
SRSF protein kinase 2
chr7_-_100239136 2.896 NM_003227
TFR2
transferrin receptor 2
chr3_+_35721115 2.810 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr17_-_79876027 2.307 SIRT7
sirtuin 7
chr14_+_21457964 2.146 NM_001029991
NM_022734
METTL17

methyltransferase like 17

chr13_-_41556360 2.103 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_-_79876024 2.080 SIRT7
sirtuin 7
chr3_-_25683825 2.051 TOP2B
topoisomerase (DNA) II beta 180kDa
chr10_+_69869249 2.048 NM_032578
MYPN
myopalladin
chr4_+_176987148 1.838 WDR17
WD repeat domain 17
chr13_-_41556188 1.831 ELF1
E74-like factor 1 (ets domain transcription factor)
chr16_+_12058963 1.798 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_-_13835313 1.649 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr17_+_56315786 1.555 NM_001160102
NM_006151
LPO

lactoperoxidase

chr8_-_17752847 1.466 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr17_+_67498391 1.252 MAP2K6
mitogen-activated protein kinase kinase 6
chr5_-_140895407 1.235 DIAPH1
diaphanous homolog 1 (Drosophila)
chr6_+_131571298 1.191 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr8_-_133459508 1.103 NM_001204824
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr12_-_11422640 1.075 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr5_-_58882274 1.064 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_166131170 1.058 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr10_-_42863435 1.018 LOC441666
zinc finger protein 91 pseudogene
chr7_+_150413597 1.003 NM_001199577
NM_130759
GIMAP1-GIMAP5
GIMAP1
GIMAP1-GIMAP5 readthrough
GTPase, IMAP family member 1
chr6_-_32160637 0.990 GPSM3
G-protein signaling modulator 3
chr12_+_111471827 0.954 NM_015267
CUX2
cut-like homeobox 2
chr4_-_70826712 0.943 NM_001891
CSN2
casein beta
chr1_-_104238785 0.917 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr12_+_14538232 0.868 ATF7IP
activating transcription factor 7 interacting protein
chr22_-_37098620 0.858 NM_006078
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chr10_+_95517565 0.849 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr10_+_124151818 0.788 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_-_45477016 0.682 NM_024602
HECTD3
HECT domain containing 3
chr6_-_24719286 0.640 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr2_-_20512016 0.604 PUM2
pumilio homolog 2 (Drosophila)
chr5_+_140247767 0.569 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr1_-_149399159 0.545 NM_001024599
HIST2H2BF
histone cluster 2, H2bf
chr6_+_72926144 0.528 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr3_+_134514044 0.354 NM_004441
EPHB1
EPH receptor B1
chr8_+_18248754 0.320 NM_000015
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr17_-_67311773 0.313 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr11_-_30605748 0.290 MPPED2
metallophosphoesterase domain containing 2
chr8_+_17822093 0.286 PCM1
pericentriolar material 1
chr11_-_47736896 0.198 NM_024783
AGBL2
ATP/GTP binding protein-like 2
chr5_-_94224601 0.187 MCTP1
multiple C2 domains, transmembrane 1
chr21_+_30400229 0.170 USP16
ubiquitin specific peptidase 16
chr2_-_152830448 0.167 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr6_-_27799304 0.140 NM_003541
HIST1H4A
HIST1H4F
HIST1H4K
HIST1H4J
histone cluster 1, H4a
histone cluster 1, H4f
histone cluster 1, H4k
histone cluster 1, H4j
chr4_+_187187117 0.080 NM_000128
F11
coagulation factor XI
chr12_-_22089627 0.072 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr3_+_119500866 0.070 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr1_-_186430216 0.067 NM_002597
PDC
phosducin
chr14_-_107199126 0.054 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr5_-_41261539 0.039 NM_001115131
C6
complement component 6
chrX_-_106362050 0.039 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr18_-_31628557 0.024 NM_001198549
NOL4
nucleolar protein 4
chr3_-_170744767 0.013 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr18_+_59157774 0.002 NM_031891
CDH20
cadherin 20, type 2
chr2_+_132480063 0.001 NM_013310
C2orf27A
chromosome 2 open reading frame 27A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.43 1.32e-03 GO:0002684 positive regulation of immune system process
4.15 2.95e-03 GO:0002682 regulation of immune system process
1.42 4.92e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.48 3.28e-04 GO:0044459 plasma membrane part
2.57 3.31e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
134.04 7.73e-03 GO:0016160 amylase activity