Motif ID: E2F1..5.p2

Z-value: 7.086


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F1chr20_-_322740700.761.1e-42Click!
E2F3chr6_+_204020400.693.2e-32Click!
E2F2chr1_-_23857284-0.505.6e-15Click!
E2F5chr8_+_860896180.425.8e-11Click!
E2F4chr16_+_672260700.186.5e-03Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_136633934 271.584 MCM6
minichromosome maintenance complex component 6
chr6_-_52149541 265.258 NM_002388
MCM3
minichromosome maintenance complex component 3
chr2_-_136634002 263.986 NM_005915
MCM6
minichromosome maintenance complex component 6
chr2_+_10262853 242.470 NM_001034
RRM2
ribonucleotide reductase M2
chr6_-_52149516 237.550 MCM3
minichromosome maintenance complex component 3
chr6_-_52149472 228.893 MCM3
minichromosome maintenance complex component 3
chr10_+_62538250 226.166 CDK1
cyclin-dependent kinase 1
chr2_+_10262694 223.015 NM_001165931
RRM2
ribonucleotide reductase M2
chr10_+_62538088 211.912 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr8_-_124408665 205.731 ATAD2
ATPase family, AAA domain containing 2
chr22_+_20105145 203.658 RANBP1
RAN binding protein 1
chr7_-_99698993 203.573 MCM7
minichromosome maintenance complex component 7
chr7_-_99699030 203.412 MCM7
minichromosome maintenance complex component 7
chrX_-_53449548 201.544 SMC1A
structural maintenance of chromosomes 1A
chr8_-_124408688 200.968 NM_014109
ATAD2
ATPase family, AAA domain containing 2
chr20_-_5100443 200.759 NM_182649
PCNA
proliferating cell nuclear antigen
chr22_+_20105076 196.971 RANBP1
RAN binding protein 1
chr22_+_20105095 196.736 RANBP1
RAN binding protein 1
chr15_-_64673569 196.103 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr22_+_35796104 189.616 NM_006739
MCM5
minichromosome maintenance complex component 5
chr8_-_124408458 187.590 ATAD2
ATPase family, AAA domain containing 2
chr7_-_99698916 185.546 MCM7
minichromosome maintenance complex component 7
chr7_-_99699426 177.483 NM_005916
MCM7
minichromosome maintenance complex component 7
chr22_+_35796154 167.980 MCM5
minichromosome maintenance complex component 5
chr3_+_127317271 167.149 MCM2
minichromosome maintenance complex component 2
chr3_+_127317274 162.290 MCM2
minichromosome maintenance complex component 2
chr3_+_127317212 155.719 NM_004526
MCM2
minichromosome maintenance complex component 2
chr8_-_121457387 142.322 MRPL13
mitochondrial ribosomal protein L13
chr22_+_35796294 135.305 MCM5
minichromosome maintenance complex component 5
chr7_+_26241329 134.199 CBX3
chromobox homolog 3
chr22_+_20105068 132.348 RANBP1
RAN binding protein 1
chr10_-_58121019 130.402 NM_001005413
NM_007057
NM_032997
ZWINT


ZW10 interactor


chr10_-_58121011 129.884 ZWINT
ZW10 interactor
chr8_-_121457333 127.585 MRPL13
mitochondrial ribosomal protein L13
chr20_+_25388320 126.148 NM_021067
GINS1
GINS complex subunit 1 (Psf1 homolog)
chr8_-_121457625 125.498 NM_014078
MRPL13
mitochondrial ribosomal protein L13
chr6_+_24775640 121.587 NM_001251991
GMNN
geminin, DNA replication inhibitor
chr19_-_10305600 121.560 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr10_-_75006963 116.399 NM_015190
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr6_+_24775154 113.122 NM_001251989
NM_001251990
NM_015895
GMNN


geminin, DNA replication inhibitor


chr13_+_34392205 111.965 NM_002915
NM_181558
RFC3

replication factor C (activator 1) 3, 38kDa

chr14_-_55658205 110.868 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr6_+_135502445 110.137 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr4_-_170679027 109.692 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr17_+_38444130 107.426 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr15_+_41624891 105.762 NM_001243142
NM_001243143
NM_001243144
NM_016359
NM_018454
NUSAP1




nucleolar and spindle associated protein 1




chr8_-_27695288 104.808 NM_018492
PBK
PDZ binding kinase
chr1_+_33116748 104.155 NM_001135255
NM_005610
NM_001135256
RBBP4


retinoblastoma binding protein 4


chr6_+_135502477 103.326 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr19_-_10305536 103.262 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr20_+_25388328 98.959 GINS1
GINS complex subunit 1 (Psf1 homolog)
chr9_+_100745584 98.025 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr2_+_232573226 95.581 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr7_+_26241372 93.857 CBX3
chromobox homolog 3
chr7_+_26241281 93.816 NM_016587
CBX3
chromobox homolog 3
chr7_+_26241044 93.155 CBX3
chromobox homolog 3
chr6_+_20402040 92.816 NM_001949
E2F3
E2F transcription factor 3
chr14_+_51706885 92.238 NM_030755
TMX1
thioredoxin-related transmembrane protein 1
chr17_+_30264140 91.897 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr13_+_34392254 89.346 RFC3
replication factor C (activator 1) 3, 38kDa
chr16_-_85722503 88.949 GINS2
GINS complex subunit 2 (Psf2 homolog)
chr16_-_85722587 88.642 NM_016095
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr19_-_10305645 87.765 NM_001130823
NM_001379
DNMT1

DNA (cytosine-5-)-methyltransferase 1

chr17_+_30264039 87.336 NM_015355
SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr15_-_66648991 86.805 NM_017858
TIPIN
TIMELESS interacting protein
chr6_+_135502521 86.484 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr7_-_44887567 86.479 H2AFV
H2A histone family, member V
chr11_+_4116059 86.017 RRM1
ribonucleotide reductase M1
chr17_+_30264065 85.782 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr15_+_41625052 81.741 NUSAP1
nucleolar and spindle associated protein 1
chr8_+_128748312 81.488 NM_002467
MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr7_+_26240830 81.448 NM_007276
CBX3
chromobox homolog 3
chr7_-_158497432 80.910 NM_017760
NCAPG2
non-SMC condensin II complex, subunit G2
chr11_-_118966175 80.348 NM_002105
H2AFX
H2A histone family, member X
chr8_+_128748476 80.228 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr17_+_38444134 80.064 NM_001254
CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr13_+_114239047 79.273 NM_007111
TFDP1
transcription factor Dp-1
chr11_+_4115923 79.040 NM_001033
RRM1
ribonucleotide reductase M1
chr7_-_44887620 78.718 H2AFV
H2A histone family, member V
chr11_-_57103324 78.602 NM_003146
SSRP1
structure specific recognition protein 1
chr11_+_125495853 78.131 CHEK1
checkpoint kinase 1
chr9_+_86595636 76.056 NM_024945
RMI1
RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
chr6_-_17706617 75.377 NM_005124
NUP153
nucleoporin 153kDa
chr11_+_64808375 74.180 NM_013299
SAC3D1
SAC3 domain containing 1
chr1_+_62902735 73.674 USP1
ubiquitin specific peptidase 1
chr2_-_47168902 73.057 NM_001171508
NM_001171511
MCFD2

multiple coagulation factor deficiency 2

chr11_+_64808395 73.023 SAC3D1
SAC3 domain containing 1
chr5_-_79950307 72.691 DHFR
dihydrofolate reductase
chr7_-_148581377 72.094 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_-_225615701 71.663 LBR
lamin B receptor
chrX_+_123095555 70.421 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr17_+_38444151 70.237 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chrX_+_133594225 69.737 HPRT1
hypoxanthine phosphoribosyltransferase 1
chr17_-_17184011 69.525 NM_001199125
COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr7_+_139044696 69.366 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr1_+_165797060 69.047 UCK2
uridine-cytidine kinase 2
chr7_-_26240364 68.851 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr7_-_148581297 68.461 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr11_-_77850687 68.405 NM_001007027
NM_024079
ALG8

asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)

chr7_+_139044701 68.382 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr16_-_12009568 68.218


chr7_-_148581403 67.949 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr2_+_47630246 67.894 NM_000251
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr5_-_79950783 67.335 NM_000791
DHFR
dihydrofolate reductase
chr1_-_205719340 66.791 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr12_-_31479120 66.436 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr1_-_26232643 66.302 NM_203401
STMN1
stathmin 1
chrX_+_106871653 65.835 NM_001204402
NM_002764
PRPS1

phosphoribosyl pyrophosphate synthetase 1

chr10_+_13203547 65.518 NM_018518
NM_182751
MCM10

minichromosome maintenance complex component 10

chr9_+_100745456 64.719 NM_006401
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_62902653 64.073 USP1
ubiquitin specific peptidase 1
chr1_-_26233367 64.004 NM_203399
STMN1
stathmin 1
chr1_+_28157322 63.829 NM_002713
NM_138558
PPP1R8

protein phosphatase 1, regulatory subunit 8

chr12_+_109535922 62.998 NM_003362
UNG
uracil-DNA glycosylase
chr7_-_148581359 62.911 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr16_-_12009918 62.864 GSPT1
G1 to S phase transition 1
chrX_+_118708536 62.629 UBE2A
ubiquitin-conjugating enzyme E2A
chr9_+_91926109 62.622 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr1_+_62902708 62.593 USP1
ubiquitin specific peptidase 1
chrX_+_106871739 62.480 PRPS1
phosphoribosyl pyrophosphate synthetase 1
chr6_-_153304093 62.394 NM_012177
FBXO5
F-box protein 5
chr1_+_28157335 62.349 PPP1R8
protein phosphatase 1, regulatory subunit 8
chr7_-_26240320 62.304 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr1_-_24306739 62.284 SRSF10
serine/arginine-rich splicing factor 10
chr12_-_31479038 62.227 FAM60A
family with sequence similarity 60, member A
chrX_+_133594171 61.761 NM_000194
HPRT1
hypoxanthine phosphoribosyltransferase 1
chr1_-_205719157 61.558 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr15_-_41624760 61.462 NM_007280
OIP5
Opa interacting protein 5
chr19_+_16187315 61.329 TPM4
tropomyosin 4
chr9_-_35079520 60.594 FANCG
Fanconi anemia, complementation group G
chr1_-_28241233 60.519 NM_002946
RPA2
replication protein A2, 32kDa
chr1_+_212209129 60.415 DTL
denticleless homolog (Drosophila)
chr14_-_50154920 60.194 POLE2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr12_-_31479084 60.160 FAM60A
family with sequence similarity 60, member A
chr1_-_33502470 59.729 AK2
adenylate kinase 2
chr7_-_26240366 59.538 NM_002137
NM_031243
HNRNPA2B1

heterogeneous nuclear ribonucleoprotein A2/B1

chr4_-_56502358 58.878 NM_006681
NMU
neuromedin U
chr1_+_28157251 58.373 NM_014110
PPP1R8
protein phosphatase 1, regulatory subunit 8
chr14_-_50155097 58.342 NM_001197330
NM_001197331
NM_002692
POLE2


polymerase (DNA directed), epsilon 2 (p59 subunit)


chr9_-_35079751 58.315 NM_004629
FANCG
Fanconi anemia, complementation group G
chr17_-_56084514 58.227 SRSF1
serine/arginine-rich splicing factor 1
chr14_+_35452103 58.118 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr19_-_1095380 58.038 NM_002695
POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr6_-_13814546 57.704 NM_001031713
CCDC90A
coiled-coil domain containing 90A
chr1_-_225615787 56.673 NM_002296
LBR
lamin B receptor
chr3_-_133380626 56.579 NM_007027
TOPBP1
topoisomerase (DNA) II binding protein 1
chrX_+_133594297 56.441 HPRT1
hypoxanthine phosphoribosyltransferase 1
chr17_-_56084611 56.316 SRSF1
serine/arginine-rich splicing factor 1
chr15_+_41625152 56.178 NUSAP1
nucleolar and spindle associated protein 1
chr2_-_47168870 55.742 MCFD2
multiple coagulation factor deficiency 2
chr16_-_23607603 55.524 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr2_+_47630291 55.517 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr18_+_19192229 55.316 NM_006938
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr7_-_148581379 55.281 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_+_139044604 55.173 NM_016019
LUC7L2
LUC7-like 2 (S. cerevisiae)
chrX_+_123095598 55.013 STAG2
stromal antigen 2
chrX_-_53449610 54.696 NM_006306
SMC1A
structural maintenance of chromosomes 1A
chr1_+_212208918 54.667 NM_016448
DTL
denticleless homolog (Drosophila)
chr14_+_35452194 54.512 SRP54
signal recognition particle 54kDa
chr3_+_44803208 54.257 NM_020242
KIF15
kinesin family member 15
chrX_+_118708540 53.668 UBE2A
ubiquitin-conjugating enzyme E2A
chr16_-_12009734 53.527 GSPT1
G1 to S phase transition 1
chr3_+_44803280 53.476 KIF15
kinesin family member 15
chr5_-_79950348 53.425 DHFR
dihydrofolate reductase
chr19_+_16187306 53.421 TPM4
tropomyosin 4
chr1_-_26232890 52.848 NM_001145454
NM_005563
STMN1

stathmin 1

chr12_-_111180636 52.294 PPP1CC
protein phosphatase 1, catalytic subunit, gamma isozyme
chr2_-_176046120 52.263 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chrX_+_131157635 52.115 NM_001042452
MST4
serine/threonine protein kinase MST4
chr11_+_47586887 51.920 NM_001143984
NM_175732
PTPMT1

protein tyrosine phosphatase, mitochondrial 1

chr19_-_1095316 51.087 POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr17_-_56084571 51.047 SRSF1
serine/arginine-rich splicing factor 1
chr2_+_47630190 50.932 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chrX_+_131157231 50.405 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr1_-_33502464 50.312 AK2
adenylate kinase 2
chrX_+_118708476 50.153 NM_003336
NM_181762
UBE2A

ubiquitin-conjugating enzyme E2A

chr10_+_112327411 50.028 NM_005445
SMC3
structural maintenance of chromosomes 3
chr17_-_78120759 50.001 NM_014740
EIF4A3
eukaryotic translation initiation factor 4A3
chr12_-_111180730 49.946 NM_001244974
NM_002710
PPP1CC

protein phosphatase 1, catalytic subunit, gamma isozyme

chr19_-_1095373 49.924 POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr14_+_75348592 49.702 NM_001244883
NM_001933
DLST

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

chr2_-_31361364 49.681


chr10_+_124913884 49.548 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr16_-_50402685 49.286 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr12_+_109535377 48.855 NM_080911
UNG
uracil-DNA glycosylase
chr7_+_94285620 48.752 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr17_+_3572089 48.681 NM_001014764
NM_031298
TMEM93

transmembrane protein 93

chr17_-_17184500 48.670 COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr3_+_14220343 48.652 LSM3
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_27440342 48.365 CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr17_+_57642885 48.287 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr11_-_14541886 48.284 NM_001143937
NM_002786
PSMA1

proteasome (prosome, macropain) subunit, alpha type, 1

chr10_-_123734708 47.646 NM_001167865
NM_017615
NSMCE4A

non-SMC element 4 homolog A (S. cerevisiae)

chr8_+_48873533 47.395 MCM4
minichromosome maintenance complex component 4
chr11_-_118966103 47.319 H2AFX
H2A histone family, member X
chr1_-_245027791 46.878 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr3_-_141868208 46.608 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr7_-_73668732 46.495 NM_002914
NM_181471
RFC2

replication factor C (activator 1) 2, 40kDa

chr2_+_132250500 46.389 LOC150776
sphingomyelin phosphodiesterase 4, neutral membrane pseudogene
chr7_+_94285676 46.131 NM_001172437
NM_001172438
PEG10

paternally expressed 10


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.36 7.49e-50 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.52 2.20e-46 GO:0090304 nucleic acid metabolic process
2.15 1.01e-43 GO:0034641 cellular nitrogen compound metabolic process
2.12 2.95e-43 GO:0006807 nitrogen compound metabolic process
3.33 1.81e-41 GO:0007049 cell cycle
1.87 1.66e-40 GO:0044260 cellular macromolecule metabolic process
1.65 1.08e-39 GO:0044237 cellular metabolic process
3.74 1.79e-35 GO:0022403 cell cycle phase
3.45 4.58e-35 GO:0022402 cell cycle process
1.73 2.68e-34 GO:0043170 macromolecule metabolic process
1.59 3.01e-33 GO:0044238 primary metabolic process
1.53 6.06e-33 GO:0008152 metabolic process
3.84 1.45e-31 GO:0000278 mitotic cell cycle
3.70 2.05e-29 GO:0006259 DNA metabolic process
1.26 1.21e-23 GO:0009987 cellular process
5.77 1.56e-23 GO:0006260 DNA replication
3.29 1.01e-22 GO:0051276 chromosome organization
4.41 3.72e-22 GO:0008380 RNA splicing
5.23 3.18e-21 GO:0000375 RNA splicing, via transesterification reactions
4.32 3.30e-21 GO:0051325 interphase
3.37 6.11e-21 GO:0016071 mRNA metabolic process
4.33 6.52e-21 GO:0051329 interphase of mitotic cell cycle
2.22 6.80e-21 GO:0006996 organelle organization
3.12 1.09e-20 GO:0006396 RNA processing
2.15 3.43e-20 GO:0016070 RNA metabolic process
5.07 2.98e-19 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
5.07 2.98e-19 GO:0000398 nuclear mRNA splicing, via spliceosome
2.07 4.49e-19 GO:0010467 gene expression
1.71 4.93e-19 GO:0071840 cellular component organization or biogenesis
1.89 1.98e-18 GO:0044249 cellular biosynthetic process
1.82 2.55e-18 GO:0071841 cellular component organization or biogenesis at cellular level
1.70 6.91e-18 GO:0016043 cellular component organization
3.61 1.55e-17 GO:0006397 mRNA processing
5.65 1.96e-17 GO:0000082 G1/S transition of mitotic cell cycle
3.76 4.04e-17 GO:0006281 DNA repair
3.18 4.07e-17 GO:0006974 response to DNA damage stimulus
6.29 6.74e-17 GO:0051320 S phase
3.71 9.51e-17 GO:0010564 regulation of cell cycle process
3.38 1.09e-16 GO:0000279 M phase
1.80 1.44e-16 GO:0071842 cellular component organization at cellular level
1.82 2.05e-16 GO:0009058 biosynthetic process
6.23 3.10e-16 GO:0000084 S phase of mitotic cell cycle
2.04 6.42e-16 GO:0034645 cellular macromolecule biosynthetic process
2.02 2.10e-15 GO:0009059 macromolecule biosynthetic process
7.48 1.33e-14 GO:0006261 DNA-dependent DNA replication
5.27 2.09e-14 GO:0006310 DNA recombination
2.77 2.87e-14 GO:0051726 regulation of cell cycle
2.46 1.17e-13 GO:0033554 cellular response to stress
4.13 5.78e-13 GO:0000075 cell cycle checkpoint
3.56 1.93e-12 GO:0000280 nuclear division
3.56 1.93e-12 GO:0007067 mitosis
3.97 2.68e-12 GO:0071156 regulation of cell cycle arrest
3.46 6.73e-12 GO:0000087 M phase of mitotic cell cycle
3.45 7.83e-12 GO:0048285 organelle fission
10.69 1.58e-10 GO:0006271 DNA strand elongation involved in DNA replication
2.02 5.44e-10 GO:0044085 cellular component biogenesis
9.97 6.83e-10 GO:0022616 DNA strand elongation
2.20 3.86e-09 GO:0043933 macromolecular complex subunit organization
2.33 3.95e-09 GO:0065003 macromolecular complex assembly
2.89 1.16e-08 GO:0034622 cellular macromolecular complex assembly
2.92 1.24e-08 GO:0051301 cell division
2.58 1.45e-08 GO:0034621 cellular macromolecular complex subunit organization
11.05 2.05e-08 GO:0006270 DNA-dependent DNA replication initiation
5.52 2.17e-08 GO:0000216 M/G1 transition of mitotic cell cycle
4.68 2.57e-08 GO:0051028 mRNA transport
4.44 4.14e-08 GO:0050657 nucleic acid transport
4.44 4.14e-08 GO:0050658 RNA transport
4.44 4.14e-08 GO:0051236 establishment of RNA localization
2.57 5.65e-08 GO:0006325 chromatin organization
4.29 9.71e-08 GO:0006403 RNA localization
1.97 1.11e-07 GO:0022607 cellular component assembly
3.52 9.78e-07 GO:0006913 nucleocytoplasmic transport
6.23 1.32e-06 GO:0051053 negative regulation of DNA metabolic process
3.48 1.33e-06 GO:0051169 nuclear transport
14.03 1.55e-06 GO:0071897 DNA biosynthetic process
4.36 1.71e-06 GO:0007059 chromosome segregation
3.82 1.71e-06 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
3.67 2.42e-06 GO:0071103 DNA conformation change
10.29 2.47e-06 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
4.79 3.11e-06 GO:0051168 nuclear export
1.94 7.87e-06 GO:0010605 negative regulation of macromolecule metabolic process
2.05 8.14e-06 GO:0071844 cellular component assembly at cellular level
5.39 1.65e-05 GO:0006406 mRNA export from nucleus
9.84 2.57e-05 GO:0032201 telomere maintenance via semi-conservative replication
3.60 2.57e-05 GO:0006333 chromatin assembly or disassembly
1.41 3.08e-05 GO:0060255 regulation of macromolecule metabolic process
3.68 3.10e-05 GO:0006323 DNA packaging
1.86 3.18e-05 GO:0009892 negative regulation of metabolic process
4.03 4.00e-05 GO:0034728 nucleosome organization
6.23 4.41e-05 GO:0006369 termination of RNA polymerase II transcription
1.89 4.69e-05 GO:0031324 negative regulation of cellular metabolic process
9.35 4.89e-05 GO:0000722 telomere maintenance via recombination
3.84 5.09e-05 GO:0071824 protein-DNA complex subunit organization
1.48 5.85e-05 GO:0044267 cellular protein metabolic process
3.88 8.40e-05 GO:0065004 protein-DNA complex assembly
7.91 8.44e-05 GO:0006312 mitotic recombination
6.40 9.98e-05 GO:0008156 negative regulation of DNA replication
4.82 1.05e-04 GO:0006405 RNA export from nucleus
2.21 1.19e-04 GO:0070271 protein complex biogenesis
3.39 1.74e-04 GO:0051052 regulation of DNA metabolic process
1.47 1.96e-04 GO:0048522 positive regulation of cellular process
1.37 2.39e-04 GO:0031323 regulation of cellular metabolic process
9.35 2.56e-04 GO:0007062 sister chromatid cohesion
8.13 2.61e-04 GO:0090329 regulation of DNA-dependent DNA replication
5.93 2.80e-04 GO:0000070 mitotic sister chromatid segregation
3.64 2.80e-04 GO:0031570 DNA integrity checkpoint
5.46 2.98e-04 GO:0000723 telomere maintenance
4.75 3.23e-04 GO:0031124 mRNA 3'-end processing
3.86 3.90e-04 GO:0031497 chromatin assembly
5.34 3.96e-04 GO:0007051 spindle organization
5.34 3.96e-04 GO:0032200 telomere organization
1.34 4.78e-04 GO:0019222 regulation of metabolic process
2.06 5.52e-04 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
2.14 5.83e-04 GO:0006461 protein complex assembly
2.02 6.71e-04 GO:0071822 protein complex subunit organization
7.48 6.77e-04 GO:0002200 somatic diversification of immune receptors
5.53 7.09e-04 GO:0000819 sister chromatid segregation
3.57 7.63e-04 GO:0051321 meiotic cell cycle
3.86 7.70e-04 GO:0006334 nucleosome assembly
4.24 7.84e-04 GO:0031123 RNA 3'-end processing
8.42 8.01e-04 GO:0006298 mismatch repair
8.42 8.01e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
1.47 1.19e-03 GO:0048523 negative regulation of cellular process
1.41 1.27e-03 GO:0048518 positive regulation of biological process
8.02 1.33e-03 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
8.02 1.33e-03 GO:0016444 somatic cell DNA recombination
9.35 1.34e-03 GO:0006297 nucleotide-excision repair, DNA gap filling
1.84 1.47e-03 GO:0046907 intracellular transport
2.45 1.54e-03 GO:0006366 transcription from RNA polymerase II promoter
2.51 1.71e-03 GO:0007346 regulation of mitotic cell cycle
2.07 1.72e-03 GO:0006753 nucleoside phosphate metabolic process
2.07 1.72e-03 GO:0009117 nucleotide metabolic process
2.28 1.75e-03 GO:0016568 chromatin modification
3.98 2.08e-03 GO:0006275 regulation of DNA replication
2.21 2.27e-03 GO:0006091 generation of precursor metabolites and energy
3.05 2.30e-03 GO:0000226 microtubule cytoskeleton organization
3.43 2.80e-03 GO:0007126 meiosis
3.43 2.80e-03 GO:0051327 M phase of meiotic cell cycle
1.65 3.24e-03 GO:0044248 cellular catabolic process
2.37 3.35e-03 GO:0009141 nucleoside triphosphate metabolic process
1.93 3.85e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
12.47 3.94e-03 GO:0002566 somatic diversification of immune receptors via somatic mutation
12.47 3.94e-03 GO:0016446 somatic hypermutation of immunoglobulin genes
1.42 4.91e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.33 5.04e-03 GO:0080090 regulation of primary metabolic process
1.90 5.70e-03 GO:0009057 macromolecule catabolic process
1.90 5.70e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.87 5.80e-03 GO:0046483 heterocycle metabolic process
1.38 6.12e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.98 6.82e-03 GO:0044265 cellular macromolecule catabolic process
6.03 6.84e-03 GO:0010833 telomere maintenance via telomere lengthening
4.01 8.11e-03 GO:0006302 double-strand break repair
1.55 8.26e-03 GO:0009056 catabolic process
1.69 8.29e-03 GO:0032774 RNA biosynthetic process
1.62 9.33e-03 GO:0010604 positive regulation of macromolecule metabolic process
11.22 9.41e-03 GO:0006301 postreplication repair
1.40 9.89e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.19 9.96e-03 GO:0050794 regulation of cellular process
1.41 1.05e-02 GO:0048519 negative regulation of biological process
1.83 1.20e-02 GO:0031327 negative regulation of cellular biosynthetic process
2.30 1.33e-02 GO:0009144 purine nucleoside triphosphate metabolic process
1.86 1.48e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.71 1.58e-02 GO:0006351 transcription, DNA-dependent
2.07 1.66e-02 GO:0016032 viral reproduction
3.79 1.68e-02 GO:0006353 transcription termination, DNA-dependent
3.07 1.70e-02 GO:0045333 cellular respiration
1.57 1.85e-02 GO:0009893 positive regulation of metabolic process
18.70 1.89e-02 GO:0019985 translesion synthesis
2.19 2.18e-02 GO:0009259 ribonucleotide metabolic process
1.34 2.18e-02 GO:0019538 protein metabolic process
1.38 2.18e-02 GO:0006950 response to stress
1.79 2.30e-02 GO:0009890 negative regulation of biosynthetic process
1.37 2.41e-02 GO:0010468 regulation of gene expression
6.80 2.50e-02 GO:0016445 somatic diversification of immunoglobulins
1.81 2.77e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
3.18 2.91e-02 GO:0000077 DNA damage checkpoint
1.64 3.27e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.92 3.33e-02 GO:0044283 small molecule biosynthetic process
4.32 3.43e-02 GO:0033044 regulation of chromosome organization
7.70 3.48e-02 GO:0016447 somatic recombination of immunoglobulin gene segments
2.92 3.54e-02 GO:0022900 electron transport chain
2.00 3.57e-02 GO:0072521 purine-containing compound metabolic process
1.35 3.95e-02 GO:0031326 regulation of cellular biosynthetic process
11.69 4.94e-02 GO:0000731 DNA synthesis involved in DNA repair
11.69 4.94e-02 GO:0045910 negative regulation of DNA recombination
1.56 4.94e-02 GO:0031325 positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.97 2.02e-77 GO:0044428 nuclear part
2.74 7.75e-65 GO:0070013 intracellular organelle lumen
2.70 1.34e-64 GO:0031974 membrane-enclosed lumen
2.99 3.20e-64 GO:0031981 nuclear lumen
2.71 6.25e-64 GO:0043233 organelle lumen
1.88 5.57e-63 GO:0044446 intracellular organelle part
1.87 1.09e-62 GO:0044422 organelle part
1.55 6.57e-61 GO:0043227 membrane-bounded organelle
1.48 3.33e-60 GO:0043226 organelle
1.54 4.53e-60 GO:0043231 intracellular membrane-bounded organelle
1.37 9.80e-60 GO:0044424 intracellular part
1.47 1.73e-59 GO:0043229 intracellular organelle
3.29 1.23e-56 GO:0005654 nucleoplasm
1.35 1.25e-56 GO:0005622 intracellular
1.82 1.21e-54 GO:0005634 nucleus
1.86 3.85e-31 GO:0032991 macromolecular complex
3.53 2.45e-26 GO:0005694 chromosome
3.41 7.57e-20 GO:0044427 chromosomal part
1.81 2.26e-19 GO:0043228 non-membrane-bounded organelle
1.81 2.26e-19 GO:0043232 intracellular non-membrane-bounded organelle
2.81 3.71e-19 GO:0044451 nucleoplasm part
3.10 2.05e-17 GO:0030529 ribonucleoprotein complex
1.32 3.16e-17 GO:0005737 cytoplasm
4.36 3.90e-16 GO:0000228 nuclear chromosome
1.66 1.58e-14 GO:0043234 protein complex
1.10 4.35e-13 GO:0044464 cell part
1.10 4.52e-13 GO:0005623 cell
4.89 9.38e-13 GO:0005681 spliceosomal complex
4.29 2.61e-12 GO:0044454 nuclear chromosome part
3.76 8.08e-12 GO:0016604 nuclear body
3.58 5.02e-11 GO:0000785 chromatin
2.58 5.24e-10 GO:0005730 nucleolus
5.68 6.64e-10 GO:0071013 catalytic step 2 spliceosome
2.21 9.99e-09 GO:0031967 organelle envelope
2.17 2.41e-08 GO:0031975 envelope
1.31 3.69e-08 GO:0044444 cytoplasmic part
11.43 9.20e-08 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
7.08 1.16e-06 GO:0005657 replication fork
1.54 4.80e-06 GO:0005829 cytosol
2.48 1.67e-05 GO:0019866 organelle inner membrane
4.33 1.96e-05 GO:0000790 nuclear chromatin
5.29 2.94e-05 GO:0034708 methyltransferase complex
5.29 2.94e-05 GO:0035097 histone methyltransferase complex
3.59 3.49e-05 GO:0016607 nuclear speck
3.36 3.59e-05 GO:0000793 condensed chromosome
2.71 5.17e-05 GO:0005635 nuclear envelope
8.86 8.22e-05 GO:0031519 PcG protein complex
3.74 2.31e-04 GO:0032993 protein-DNA complex
14.03 2.45e-04 GO:0042555 MCM complex
3.27 6.07e-04 GO:0044455 mitochondrial membrane part
12.47 7.01e-04 GO:0035098 ESC/E(Z) complex
1.58 7.21e-04 GO:0005739 mitochondrion
1.85 7.49e-04 GO:0044429 mitochondrial part
4.13 9.80e-04 GO:0034399 nuclear periphery
4.07 1.19e-03 GO:0005643 nuclear pore
2.26 1.83e-03 GO:0005743 mitochondrial inner membrane
2.90 2.76e-03 GO:0000775 chromosome, centromeric region
3.61 2.95e-03 GO:0046930 pore complex
9.35 6.70e-03 GO:0032300 mismatch repair complex
3.92 8.21e-03 GO:0016363 nuclear matrix
3.29 9.93e-03 GO:0016585 chromatin remodeling complex
1.91 1.03e-02 GO:0005740 mitochondrial envelope
2.51 1.31e-02 GO:0005819 spindle
4.01 1.35e-02 GO:0016605 PML body
3.74 2.78e-02 GO:0000123 histone acetyltransferase complex
3.68 3.30e-02 GO:0005746 mitochondrial respiratory chain
1.87 3.35e-02 GO:0031966 mitochondrial membrane
4.25 3.60e-02 GO:0000792 heterochromatin
5.95 4.28e-02 GO:0043596 nuclear replication fork

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.53 1.92e-37 GO:0005515 protein binding
1.24 2.67e-25 GO:0005488 binding
1.70 8.62e-19 GO:0003676 nucleic acid binding
2.57 5.54e-17 GO:0003723 RNA binding
1.73 6.24e-13 GO:0000166 nucleotide binding
3.42 1.53e-07 GO:0003682 chromatin binding
1.56 1.54e-07 GO:0003677 DNA binding
5.58 2.22e-06 GO:0003697 single-stranded DNA binding
5.05 1.18e-05 GO:0008094 DNA-dependent ATPase activity
3.03 2.97e-05 GO:0043566 structure-specific DNA binding
7.09 7.85e-05 GO:0034061 DNA polymerase activity
1.51 2.21e-04 GO:0035639 purine ribonucleoside triphosphate binding
7.19 2.52e-04 GO:0003887 DNA-directed DNA polymerase activity
1.49 4.73e-04 GO:0017076 purine nucleotide binding
1.48 5.66e-04 GO:0032553 ribonucleotide binding
1.48 5.66e-04 GO:0032555 purine ribonucleotide binding
1.24 9.09e-04 GO:0003824 catalytic activity
3.89 1.43e-03 GO:0003729 mRNA binding
9.35 1.71e-03 GO:0030983 mismatched DNA binding
1.52 1.88e-03 GO:0005524 ATP binding
4.68 3.40e-03 GO:0003684 damaged DNA binding
1.50 3.86e-03 GO:0032559 adenyl ribonucleotide binding
1.49 4.98e-03 GO:0030554 adenyl nucleotide binding
1.71 6.02e-03 GO:0016462 pyrophosphatase activity
1.72 6.46e-03 GO:0017111 nucleoside-triphosphatase activity
1.71 6.87e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.70 7.83e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
2.06 1.50e-02 GO:0016887 ATPase activity
3.54 1.84e-02 GO:0042393 histone binding
4.68 2.03e-02 GO:0003678 DNA helicase activity
14.96 2.18e-02 GO:0019238 cyclohydrolase activity