Motif ID: EGR1..3.p2

Z-value: 2.006


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR3chr8_-_22550057,
chr8_-_22549901
0.529.1e-17Click!
EGR1chr5_+_1378011780.236.3e-04Click!
EGR2chr10_-_645789260.111.1e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_124609775 43.717 NM_001126181
NM_006176
NRGN

neurogranin (protein kinase C substrate, RC3)

chr11_+_124609841 35.086 NRGN
neurogranin (protein kinase C substrate, RC3)
chr6_-_46459010 34.654 NM_001251974
RCAN2
regulator of calcineurin 2
chr1_+_6845381 33.173 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chrX_-_47479229 28.142 NM_006950
NM_133499
SYN1

synapsin I

chr10_-_75255718 27.699 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_+_79258517 24.640 SYT1
synaptotagmin I
chr20_-_50384861 24.146 ATP9A
ATPase, class II, type 9A
chr12_+_79258588 23.089 SYT1
synaptotagmin I
chr11_-_236833 23.088 SIRT3
sirtuin 3
chr4_-_102267952 23.060 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr14_+_29236882 22.683 FOXG1
forkhead box G1
chr20_-_62130390 22.563 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr7_-_44365019 21.273 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr12_+_79258794 20.671 SYT1
synaptotagmin I
chr7_+_55955129 20.080 ZNF713
zinc finger protein 713
chr7_+_64498643 19.747 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr16_-_19896105 19.267 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr7_-_51384458 18.727 NM_015198
COBL
cordon-bleu homolog (mouse)
chr20_+_10199455 18.121 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr14_+_100150596 17.821 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr12_+_79258448 17.613 NM_005639
SYT1
synaptotagmin I
chr20_+_44035203 17.480 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr7_-_32931409 17.462 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr20_-_50384899 17.424 NM_006045
ATP9A
ATPase, class II, type 9A
chr20_+_44034632 17.169 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr12_-_124457099 17.134 NM_025140
CCDC92
coiled-coil domain containing 92
chr3_+_50712671 16.825 NM_004947
DOCK3
dedicator of cytokinesis 3
chr12_-_96793797 16.742 CDK17
cyclin-dependent kinase 17
chr4_-_102268626 15.509 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr7_+_65338161 15.507 NM_173517
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr15_-_73925555 15.304 NPTN
neuroplastin
chr1_-_154193044 14.807 C1orf43
chromosome 1 open reading frame 43
chrX_+_101380659 14.451 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr1_+_77747602 14.354 NM_174858
AK5
adenylate kinase 5
chr14_-_23821423 14.353 NM_020372
SLC22A17
solute carrier family 22, member 17
chr22_+_19701968 14.214 NM_002688
SEPT5
septin 5
chr11_-_134281725 14.120 NM_018644
NM_054025
B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr19_+_708766 14.030 NM_001040134
NM_002579
PALM

paralemmin

chr17_-_8066254 14.008 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr12_-_106532447 13.734 NUAK1
NUAK family, SNF1-like kinase, 1
chr6_-_35656610 13.659 FKBP5
FK506 binding protein 5
chr1_-_9189087 13.362 NM_024980
GPR157
G protein-coupled receptor 157
chr20_+_17207669 13.257 PCSK2
proprotein convertase subtilisin/kexin type 2
chrX_+_47092362 12.989 USP11
ubiquitin specific peptidase 11
chr4_-_102268333 12.572 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr16_+_56225301 12.529 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr17_-_74236272 12.450 NM_052916
RNF157
ring finger protein 157
chr14_-_23822025 12.412 NM_016609
SLC22A17
solute carrier family 22, member 17
chr1_+_38259458 12.226 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr9_-_139907614 12.163 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr20_+_34742656 12.084 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr5_+_139493689 12.062 NM_005859
PURA
purine-rich element binding protein A
chr4_-_5890142 12.026 CRMP1
collapsin response mediator protein 1
chr7_-_150945731 11.953 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr16_-_402617 11.947 NM_003502
NM_181050
AXIN1

axin 1

chr7_-_108096693 11.760 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr9_+_137979513 11.684 OLFM1
olfactomedin 1
chr6_-_84418705 11.536 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr19_+_18208596 11.525 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr14_-_21493910 11.424 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr13_+_98086681 11.332 RAP2A
RAP2A, member of RAS oncogene family
chr15_-_72410226 11.330 NM_006901
MYO9A
myosin IXA
chr13_-_45150391 11.293 TSC22D1
TSC22 domain family, member 1
chr20_-_61569227 11.292 DIDO1
death inducer-obliterator 1
chr9_+_17578952 11.276 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr2_+_10183630 11.243 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr11_-_12030838 11.091 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_-_20812727 11.087 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr15_-_72410108 11.076 MYO9A
myosin IXA
chr6_-_110500803 11.072 WASF1
WAS protein family, member 1
chr17_-_1083008 11.055 NM_021962
ABR
active BCR-related gene
chr10_-_15413054 10.989 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr17_+_79008958 10.979 BAIAP2
BAI1-associated protein 2
chr17_-_79008372 10.922 FLJ90757
uncharacterized LOC440465
chr16_+_84178864 10.898 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr19_+_35634153 10.869 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chr3_-_49907304 10.865 NM_024046
CAMKV
CaM kinase-like vesicle-associated
chr16_+_84002099 10.858 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr19_-_42498320 10.854 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr9_-_13279562 10.813 MPDZ
multiple PDZ domain protein
chr5_+_172483285 10.784 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr11_-_12030882 10.751 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr17_+_79008945 10.683 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr7_+_102715580 10.539 ARMC10
armadillo repeat containing 10
chr11_-_12030539 10.529 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr7_+_35840595 10.482 NM_001011553
NM_001242956
NM_001788
SEPT7


septin 7


chr11_-_12030622 10.466 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_-_42498221 10.443 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr12_+_77157885 10.275 ZDHHC17
zinc finger, DHHC-type containing 17
chr3_-_14989399 10.248 LOC100505641
uncharacterized LOC100505641
chr3_-_171177851 10.247 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr7_-_143059144 10.234 NM_014690
FAM131B
family with sequence similarity 131, member B
chr19_-_36523770 10.191 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr1_+_169075869 10.179 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr4_+_71570768 10.081 RUFY3
RUN and FYVE domain containing 3
chr15_-_73925658 10.041 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr7_+_45614081 9.961 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr22_+_39745757 9.927 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr1_+_33352071 9.915 NM_002143
HPCA
hippocalcin
chrX_-_70288155 9.885 NM_013346
SNX12
sorting nexin 12
chr10_+_111985628 9.868 NM_005962
MXI1
MAX interactor 1
chr8_-_144241918 9.848 NM_001130478
LY6H
lymphocyte antigen 6 complex, locus H
chr9_-_135230129 9.809 SETX
senataxin
chr1_+_65720091 9.769 LOC645195
DNAJC6
uncharacterized LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr2_+_149633173 9.733


chr13_+_98086315 9.682 NM_021033
RAP2A
RAP2A, member of RAS oncogene family
chr11_-_123525300 9.645 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr13_-_80915041 9.579 NM_005842
SPRY2
sprouty homolog 2 (Drosophila)
chr7_-_32931363 9.577 KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr5_+_137801178 9.575 NM_001964
EGR1
early growth response 1
chr9_+_123963728 9.496 GSN
gelsolin
chr4_-_36245893 9.465 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_123524881 9.463 SCN3B
sodium channel, voltage-gated, type III, beta
chr5_+_137801166 9.449 EGR1
early growth response 1
chr12_+_121078421 9.444 NM_001033677
CABP1
calcium binding protein 1
chr19_+_18794391 9.431 NM_001098482
NM_015321
CRTC1

CREB regulated transcription coactivator 1

chr6_+_107811272 9.396 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr1_-_200638996 9.394 DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr20_-_48099178 9.392 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr16_+_2588000 9.352 PDPK1
3-phosphoinositide dependent protein kinase-1
chr19_+_35760002 9.330 USF2
upstream transcription factor 2, c-fos interacting
chr19_+_36266366 9.197 NM_001172630
NM_052948
ARHGAP33

Rho GTPase activating protein 33

chr19_+_16435734 9.106 KLF2
Kruppel-like factor 2 (lung)
chrX_-_51239426 8.962 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chrX_+_47092264 8.932 NM_004651
USP11
ubiquitin specific peptidase 11
chr1_+_77747727 8.880 AK5
adenylate kinase 5
chr20_-_61569265 8.771 NM_022105
NM_033081
NM_080797
DIDO1


death inducer-obliterator 1


chr7_+_95401817 8.762 NM_001135556
NM_001135557
NM_004411
DYNC1I1


dynein, cytoplasmic 1, intermediate chain 1


chr7_+_24323806 8.743 NM_000905
NPY
neuropeptide Y
chr11_-_236324 8.716 NM_001017524
NM_012239
SIRT3

sirtuin 3

chr5_-_11903964 8.686 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr2_+_139259476 8.685


chr1_-_32229635 8.683 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr19_-_13617037 8.675 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr10_-_75634219 8.666 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr13_+_42846255 8.630 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chr3_-_14988976 8.628 LOC100505641
uncharacterized LOC100505641
chr6_-_84419108 8.578 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr16_+_28834407 8.573 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr3_-_9439122 8.565 LOC440944
uncharacterized LOC440944
chr17_+_30813928 8.543 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr14_+_29236171 8.511 NM_005249
FOXG1
forkhead box G1
chr16_+_2587989 8.504 PDPK1
3-phosphoinositide dependent protein kinase-1
chr16_+_2588021 8.461 PDPK1
3-phosphoinositide dependent protein kinase-1
chr10_-_75255747 8.444 NM_001142353
NM_001142354
NM_021132
PPP3CB


protein phosphatase 3, catalytic subunit, beta isozyme


chr2_-_25896282 8.374 NM_021907
NM_033147
NM_033148
NM_183360
NM_183361
DTNB




dystrobrevin, beta




chr3_+_20081853 8.353 KAT2B
K(lysine) acetyltransferase 2B
chr12_-_133532847 8.343 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr19_+_589849 8.334 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr8_-_144241678 8.287 LY6H
lymphocyte antigen 6 complex, locus H
chr20_+_19193364 8.268 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr3_-_45267804 8.153 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr13_-_45150601 8.152 NM_001243799
NM_183422
TSC22D1

TSC22 domain family, member 1

chr11_+_45907198 8.149 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr8_+_1922030 8.140 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr10_+_124220990 8.137 NM_002775
HTRA1
HtrA serine peptidase 1
chr20_+_19193282 8.123 NM_020689
SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr17_+_77751929 8.058 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr16_+_2039945 8.023 NM_004209
SYNGR3
synaptogyrin 3
chr19_+_11457160 7.999 NM_001080503
CCDC159
coiled-coil domain containing 159
chr5_+_76506705 7.986 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr3_-_57113292 7.962 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr2_-_99552677 7.948 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr15_+_80696569 7.914 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr4_-_105412466 7.890 NM_025212
CXXC4
CXXC finger protein 4
chr7_-_150946031 7.870 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_+_154301219 7.856 ATP8B2
ATPase, class I, type 8B, member 2
chr19_+_47524142 7.846 NM_002517
NPAS1
neuronal PAS domain protein 1
chr5_+_7396030 7.832 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr16_+_28834372 7.771 ATXN2L
ataxin 2-like
chr8_+_94929082 7.768 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr3_+_58223228 7.756 NM_020676
ABHD6
abhydrolase domain containing 6
chr7_+_139877154 7.752 LOC100134229
uncharacterized LOC100134229
chr7_-_102257135 7.748 RASA4
RAS p21 protein activator 4
chr15_-_83316621 7.726 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr7_-_129251465 7.721


chr18_-_29522988 7.710 TRAPPC8
trafficking protein particle complex 8
chr3_-_14988939 7.707 LOC100505641
uncharacterized LOC100505641
chr12_+_7023490 7.703 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr19_+_18794487 7.701 CRTC1
CREB regulated transcription coactivator 1
chr4_-_5890266 7.688 NM_001313
CRMP1
collapsin response mediator protein 1
chr12_+_77157842 7.658 NM_015336
ZDHHC17
zinc finger, DHHC-type containing 17
chr19_+_39833099 7.628 NM_018028
SAMD4B
sterile alpha motif domain containing 4B
chr16_-_3930713 7.620 CREBBP
CREB binding protein
chr5_+_34929679 7.570 NM_001012339
NM_194283
DNAJC21

DnaJ (Hsp40) homolog, subfamily C, member 21

chr11_+_107461807 7.522 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr11_-_113746205 7.518 NM_020886
USP28
ubiquitin specific peptidase 28
chr19_-_18654376 7.511 NM_012181
FKBP8
FK506 binding protein 8, 38kDa
chr18_-_53255734 7.483 NM_001083962
NM_001243230
NM_003199
TCF4


transcription factor 4


chr19_-_815243 7.419 LPPR3
lipid phosphate phosphatase-related protein type 3
chr9_+_35605614 7.419 TESK1
testis-specific kinase 1
chrX_-_135333519 7.415 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr8_-_144241456 7.414 NM_002347
LY6H
lymphocyte antigen 6 complex, locus H
chr22_+_19711065 7.410 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr7_+_73703704 7.404 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr15_-_65425650 7.369 NM_005707
PDCD7
programmed cell death 7
chr2_+_30369868 7.351 YPEL5
yippee-like 5 (Drosophila)
chr4_+_1795004 7.313 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr3_-_13008959 7.301 NM_014869
IQSEC1
IQ motif and Sec7 domain 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 3.86e-34 GO:0050794 regulation of cellular process
1.25 5.83e-33 GO:0065007 biological regulation
1.26 5.17e-32 GO:0050789 regulation of biological process
1.43 1.17e-31 GO:0023052 signaling
1.74 5.32e-30 GO:0007399 nervous system development
1.15 2.32e-29 GO:0009987 cellular process
1.35 2.58e-21 GO:0032502 developmental process
1.38 9.38e-21 GO:0007165 signal transduction
1.58 1.15e-20 GO:0023051 regulation of signaling
1.36 1.66e-19 GO:0007275 multicellular organismal development
1.78 4.88e-19 GO:0022008 neurogenesis
1.40 4.88e-19 GO:0048731 system development
1.37 1.47e-18 GO:0048856 anatomical structure development
2.07 3.51e-18 GO:0019226 transmission of nerve impulse
2.07 3.51e-18 GO:0035637 multicellular organismal signaling
1.78 5.04e-18 GO:0048699 generation of neurons
2.06 7.65e-16 GO:0007268 synaptic transmission
1.44 1.63e-15 GO:0048869 cellular developmental process
1.44 5.81e-15 GO:0030154 cell differentiation
1.96 1.16e-14 GO:0000904 cell morphogenesis involved in differentiation
1.52 1.55e-14 GO:0009653 anatomical structure morphogenesis
2.04 2.29e-14 GO:0007409 axonogenesis
2.01 4.10e-14 GO:0048667 cell morphogenesis involved in neuron differentiation
1.27 7.55e-14 GO:0051716 cellular response to stimulus
1.84 8.32e-14 GO:0000902 cell morphogenesis
1.99 8.72e-14 GO:0048812 neuron projection morphogenesis
1.77 1.07e-13 GO:0030182 neuron differentiation
1.61 1.08e-13 GO:0010646 regulation of cell communication
1.80 1.31e-13 GO:0007167 enzyme linked receptor protein signaling pathway
1.91 1.45e-13 GO:0032990 cell part morphogenesis
1.92 1.46e-13 GO:0048858 cell projection morphogenesis
1.30 1.69e-13 GO:0031323 regulation of cellular metabolic process
1.28 2.20e-13 GO:0019222 regulation of metabolic process
1.38 4.30e-13 GO:0048519 negative regulation of biological process
1.30 4.56e-13 GO:0080090 regulation of primary metabolic process
1.44 4.82e-13 GO:0007166 cell surface receptor linked signaling pathway
1.50 1.15e-12 GO:0009966 regulation of signal transduction
1.39 1.87e-12 GO:0048523 negative regulation of cellular process
1.89 2.16e-12 GO:0031175 neuron projection development
1.77 4.76e-12 GO:0032989 cellular component morphogenesis
1.69 7.11e-12 GO:0007267 cell-cell signaling
1.42 7.97e-12 GO:0006464 protein modification process
1.51 8.66e-12 GO:0051239 regulation of multicellular organismal process
1.76 9.54e-12 GO:0030030 cell projection organization
1.28 1.00e-11 GO:0051179 localization
1.61 1.65e-11 GO:0048468 cell development
1.33 2.84e-11 GO:0031326 regulation of cellular biosynthetic process
1.60 4.23e-11 GO:0050793 regulation of developmental process
2.03 5.75e-11 GO:0007411 axon guidance
1.77 6.87e-11 GO:0048666 neuron development
1.32 7.74e-11 GO:0009889 regulation of biosynthetic process
1.81 1.10e-10 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.28 1.41e-10 GO:0060255 regulation of macromolecule metabolic process
1.32 1.53e-10 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.57 1.84e-10 GO:0032879 regulation of localization
1.47 2.85e-10 GO:0035556 intracellular signal transduction
1.27 5.41e-10 GO:0016043 cellular component organization
1.59 5.93e-10 GO:0006351 transcription, DNA-dependent
1.38 6.85e-10 GO:0048583 regulation of response to stimulus
1.38 6.96e-10 GO:0043412 macromolecule modification
1.54 1.41e-09 GO:0007154 cell communication
1.32 1.73e-09 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.63 2.08e-09 GO:2000026 regulation of multicellular organismal development
1.20 2.28e-09 GO:0032501 multicellular organismal process
1.34 4.29e-09 GO:0006355 regulation of transcription, DNA-dependent
1.30 4.52e-09 GO:0051171 regulation of nitrogen compound metabolic process
1.30 8.09e-09 GO:0010468 regulation of gene expression
1.31 1.08e-08 GO:0010556 regulation of macromolecule biosynthetic process
1.27 1.50e-08 GO:0051234 establishment of localization
1.25 2.08e-08 GO:0071840 cellular component organization or biogenesis
1.27 2.34e-08 GO:0006810 transport
1.32 2.46e-08 GO:0051252 regulation of RNA metabolic process
1.59 2.63e-08 GO:0016192 vesicle-mediated transport
1.61 7.18e-08 GO:0045595 regulation of cell differentiation
1.49 1.32e-07 GO:0006793 phosphorus metabolic process
1.49 1.32e-07 GO:0006796 phosphate metabolic process
1.60 1.47e-07 GO:0010628 positive regulation of gene expression
1.70 1.79e-07 GO:0007417 central nervous system development
1.30 1.93e-07 GO:0042221 response to chemical stimulus
1.31 2.37e-07 GO:0065008 regulation of biological quality
1.57 2.60e-07 GO:0006468 protein phosphorylation
1.48 3.11e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.28 3.33e-07 GO:0071842 cellular component organization at cellular level
1.42 3.34e-07 GO:0051641 cellular localization
1.29 3.86e-07 GO:0048522 positive regulation of cellular process
1.27 5.20e-07 GO:0048518 positive regulation of biological process
1.53 5.41e-07 GO:0051128 regulation of cellular component organization
1.19 9.34e-07 GO:0044260 cellular macromolecule metabolic process
1.71 1.50e-06 GO:0051094 positive regulation of developmental process
1.46 2.80e-06 GO:0032774 RNA biosynthetic process
1.15 2.95e-06 GO:0044237 cellular metabolic process
1.42 3.34e-06 GO:0051649 establishment of localization in cell
1.71 3.79e-06 GO:0060341 regulation of cellular localization
1.53 4.31e-06 GO:0051049 regulation of transport
1.65 4.59e-06 GO:0048585 negative regulation of response to stimulus
1.82 5.89e-06 GO:0060284 regulation of cell development
1.73 6.98e-06 GO:0007264 small GTPase mediated signal transduction
2.35 7.29e-06 GO:0002791 regulation of peptide secretion
2.35 7.29e-06 GO:0090087 regulation of peptide transport
2.88 8.43e-06 GO:0007269 neurotransmitter secretion
2.41 8.79e-06 GO:0003001 generation of a signal involved in cell-cell signaling
2.41 8.79e-06 GO:0023061 signal release
1.57 8.84e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.86 8.86e-06 GO:0051960 regulation of nervous system development
1.68 9.71e-06 GO:0023057 negative regulation of signaling
1.25 9.75e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.67 1.14e-05 GO:0010648 negative regulation of cell communication
1.47 1.15e-05 GO:0040011 locomotion
2.34 1.24e-05 GO:0090276 regulation of peptide hormone secretion
1.54 1.63e-05 GO:0051254 positive regulation of RNA metabolic process
2.37 1.79e-05 GO:0050796 regulation of insulin secretion
1.72 2.11e-05 GO:0051056 regulation of small GTPase mediated signal transduction
1.94 2.34e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.69 2.45e-05 GO:0009968 negative regulation of signal transduction
1.46 2.86e-05 GO:0016310 phosphorylation
1.34 3.37e-05 GO:0065009 regulation of molecular function
1.90 3.65e-05 GO:0006897 endocytosis
1.90 3.65e-05 GO:0010324 membrane invagination
1.49 3.91e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 4.12e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.88 4.44e-05 GO:0050767 regulation of neurogenesis
2.15 4.49e-05 GO:0046883 regulation of hormone secretion
1.47 5.12e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.54 5.37e-05 GO:0009725 response to hormone stimulus
1.50 6.49e-05 GO:0009890 negative regulation of biosynthetic process
1.51 8.36e-05 GO:0009719 response to endogenous stimulus
1.13 8.51e-05 GO:0044238 primary metabolic process
2.45 8.79e-05 GO:0001505 regulation of neurotransmitter levels
1.58 9.76e-05 GO:0006935 chemotaxis
1.58 9.76e-05 GO:0042330 taxis
1.57 9.77e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.41 1.04e-04 GO:0009892 negative regulation of metabolic process
1.56 1.11e-04 GO:0051253 negative regulation of RNA metabolic process
1.71 1.68e-04 GO:0045597 positive regulation of cell differentiation
1.52 1.70e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.74 1.78e-04 GO:0032870 cellular response to hormone stimulus
1.52 1.97e-04 GO:0010629 negative regulation of gene expression
1.15 2.07e-04 GO:0043170 macromolecule metabolic process
1.37 2.13e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.51 2.29e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.46 2.40e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.73 2.64e-04 GO:0022603 regulation of anatomical structure morphogenesis
2.28 2.90e-04 GO:0006836 neurotransmitter transport
1.13 3.12e-04 GO:0050896 response to stimulus
1.70 3.47e-04 GO:0071495 cellular response to endogenous stimulus
1.50 3.70e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.41 4.98e-04 GO:0031324 negative regulation of cellular metabolic process
1.48 5.14e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.42 5.72e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.65 6.92e-04 GO:0007420 brain development
1.69 7.03e-04 GO:0051046 regulation of secretion
1.41 8.04e-04 GO:0009891 positive regulation of biosynthetic process
1.43 8.24e-04 GO:0046907 intracellular transport
1.57 9.93e-04 GO:0061024 membrane organization
4.54 9.96e-04 GO:0014047 glutamate secretion
1.22 1.19e-03 GO:0044267 cellular protein metabolic process
1.66 1.34e-03 GO:0043434 response to peptide hormone stimulus
1.57 1.39e-03 GO:0016044 cellular membrane organization
2.02 1.58e-03 GO:0006184 GTP catabolic process
2.06 2.30e-03 GO:0051969 regulation of transmission of nerve impulse
1.74 2.31e-03 GO:0030334 regulation of cell migration
1.32 2.31e-03 GO:0009893 positive regulation of metabolic process
1.11 2.70e-03 GO:0008152 metabolic process
1.32 2.70e-03 GO:0010033 response to organic substance
1.38 2.85e-03 GO:0010605 negative regulation of macromolecule metabolic process
2.21 3.15e-03 GO:0048754 branching morphogenesis of a tube
1.99 3.24e-03 GO:0031644 regulation of neurological system process
1.20 3.37e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53 3.64e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.82 3.69e-03 GO:0045664 regulation of neuron differentiation
1.72 3.90e-03 GO:2000145 regulation of cell motility
3.19 4.11e-03 GO:0048489 synaptic vesicle transport
1.69 4.69e-03 GO:0035295 tube development
1.35 5.52e-03 GO:0009605 response to external stimulus
2.08 5.56e-03 GO:0050804 regulation of synaptic transmission
1.67 5.83e-03 GO:0051270 regulation of cellular component movement
1.42 6.01e-03 GO:0019220 regulation of phosphate metabolic process
1.42 6.01e-03 GO:0051174 regulation of phosphorus metabolic process
1.46 6.07e-03 GO:0009887 organ morphogenesis
1.43 6.66e-03 GO:0042325 regulation of phosphorylation
1.30 7.61e-03 GO:0033036 macromolecule localization
1.31 8.19e-03 GO:0031325 positive regulation of cellular metabolic process
1.73 9.09e-03 GO:0030168 platelet activation
1.33 9.10e-03 GO:0051246 regulation of protein metabolic process
1.74 9.93e-03 GO:0071375 cellular response to peptide hormone stimulus
2.00 9.97e-03 GO:0001763 morphogenesis of a branching structure
2.00 9.97e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.35 1.12e-02 GO:0048638 regulation of developmental growth
1.59 1.14e-02 GO:0018193 peptidyl-amino acid modification
1.62 1.16e-02 GO:0032940 secretion by cell
1.60 1.20e-02 GO:0044057 regulation of system process
1.99 1.27e-02 GO:0022604 regulation of cell morphogenesis
1.97 1.29e-02 GO:0042391 regulation of membrane potential
1.89 1.30e-02 GO:0046039 GTP metabolic process
1.95 1.30e-02 GO:0008286 insulin receptor signaling pathway
1.73 1.41e-02 GO:0002009 morphogenesis of an epithelium
3.69 1.46e-02 GO:0018107 peptidyl-threonine phosphorylation
2.08 1.76e-02 GO:0010720 positive regulation of cell development
1.42 1.93e-02 GO:0001932 regulation of protein phosphorylation
1.63 1.94e-02 GO:0040012 regulation of locomotion
1.23 1.97e-02 GO:0048513 organ development
1.94 2.06e-02 GO:0006112 energy reserve metabolic process
1.80 2.11e-02 GO:0035239 tube morphogenesis
1.32 2.20e-02 GO:0032268 regulation of cellular protein metabolic process
1.37 2.45e-02 GO:0031399 regulation of protein modification process
1.53 2.47e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.63 2.55e-02 GO:0032446 protein modification by small protein conjugation
2.30 2.68e-02 GO:0050770 regulation of axonogenesis
1.54 2.72e-02 GO:0090066 regulation of anatomical structure size
1.61 2.85e-02 GO:0006366 transcription from RNA polymerase II promoter
2.07 2.86e-02 GO:0021700 developmental maturation
1.57 2.96e-02 GO:0070647 protein modification by small protein conjugation or removal
2.04 2.97e-02 GO:0061138 morphogenesis of a branching epithelium
1.50 3.10e-02 GO:0032583 regulation of gene-specific transcription
1.39 3.15e-02 GO:0009790 embryo development
1.66 3.29e-02 GO:0000165 MAPKKK cascade
1.69 3.48e-02 GO:0032868 response to insulin stimulus
1.54 3.52e-02 GO:0009792 embryo development ending in birth or egg hatching
1.31 3.53e-02 GO:0008104 protein localization
1.76 3.56e-02 GO:0048732 gland development
1.24 3.77e-02 GO:0006996 organelle organization
1.54 4.06e-02 GO:0016568 chromatin modification
1.59 4.39e-02 GO:0048729 tissue morphogenesis
2.18 4.57e-02 GO:0050769 positive regulation of neurogenesis
1.64 4.68e-02 GO:0016567 protein ubiquitination
1.77 4.82e-02 GO:0032869 cellular response to insulin stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 3.70e-24 GO:0005622 intracellular
1.13 4.42e-22 GO:0044424 intracellular part
1.99 4.77e-14 GO:0045202 synapse
1.13 1.99e-13 GO:0043226 organelle
1.15 7.78e-13 GO:0005737 cytoplasm
1.12 8.14e-13 GO:0043229 intracellular organelle
1.19 1.98e-10 GO:0005634 nucleus
1.12 2.63e-10 GO:0043227 membrane-bounded organelle
1.12 7.13e-10 GO:0043231 intracellular membrane-bounded organelle
1.97 1.15e-09 GO:0044456 synapse part
1.30 3.13e-08 GO:0044459 plasma membrane part
1.05 3.69e-08 GO:0005623 cell
1.53 4.68e-08 GO:0031982 vesicle
1.04 5.24e-08 GO:0044464 cell part
1.73 1.97e-07 GO:0043005 neuron projection
1.47 5.49e-07 GO:0042995 cell projection
1.50 7.08e-07 GO:0031410 cytoplasmic vesicle
1.51 9.43e-07 GO:0031988 membrane-bounded vesicle
1.54 4.34e-06 GO:0030054 cell junction
1.49 5.45e-06 GO:0016023 cytoplasmic membrane-bounded vesicle
2.01 2.88e-05 GO:0030136 clathrin-coated vesicle
2.29 4.92e-05 GO:0019717 synaptosome
2.78 1.65e-04 GO:0005905 coated pit
1.15 5.77e-04 GO:0071944 cell periphery
2.27 5.91e-04 GO:0030665 clathrin coated vesicle membrane
1.84 6.75e-04 GO:0031252 cell leading edge
1.98 7.21e-04 GO:0034703 cation channel complex
1.15 1.05e-03 GO:0005886 plasma membrane
2.22 1.11e-03 GO:0008021 synaptic vesicle
2.22 1.11e-03 GO:0008076 voltage-gated potassium channel complex
2.22 1.11e-03 GO:0034705 potassium channel complex
1.37 1.15e-03 GO:0005624 membrane fraction
1.37 1.23e-03 GO:0005626 insoluble fraction
1.11 1.28e-03 GO:0044444 cytoplasmic part
1.76 1.96e-03 GO:0030135 coated vesicle
1.17 2.77e-03 GO:0043234 protein complex
2.24 3.45e-03 GO:0033267 axon part
1.21 3.58e-03 GO:0005829 cytosol
1.77 4.29e-03 GO:0030424 axon
1.38 4.98e-03 GO:0015630 microtubule cytoskeleton
1.53 6.79e-03 GO:0048471 perinuclear region of cytoplasm
1.29 8.06e-03 GO:0000267 cell fraction
1.72 8.12e-03 GO:0030425 dendrite
1.36 1.01e-02 GO:0044451 nucleoplasm part
1.22 1.03e-02 GO:0031981 nuclear lumen
1.80 1.21e-02 GO:0045211 postsynaptic membrane
2.04 1.64e-02 GO:0001726 ruffle
1.97 1.76e-02 GO:0019898 extrinsic to membrane
1.25 1.95e-02 GO:0005654 nucleoplasm
1.55 2.39e-02 GO:0005874 microtubule
1.22 2.53e-02 GO:0005856 cytoskeleton
1.64 2.55e-02 GO:0034702 ion channel complex
1.55 2.94e-02 GO:0012506 vesicle membrane
1.43 3.10e-02 GO:0005768 endosome
1.18 4.95e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.24 6.95e-29 GO:0005515 protein binding
1.13 7.68e-26 GO:0005488 binding
1.58 1.54e-12 GO:0001071 nucleic acid binding transcription factor activity
1.58 1.54e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.53 1.17e-10 GO:0030528 transcription regulator activity
1.79 1.86e-10 GO:0060589 nucleoside-triphosphatase regulator activity
1.80 2.06e-10 GO:0030695 GTPase regulator activity
1.64 5.50e-10 GO:0043565 sequence-specific DNA binding
1.59 6.57e-09 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.33 3.99e-08 GO:0017076 purine nucleotide binding
1.53 8.57e-08 GO:0016301 kinase activity
1.32 8.99e-08 GO:0032553 ribonucleotide binding
1.32 8.99e-08 GO:0032555 purine ribonucleotide binding
1.29 1.67e-07 GO:0000166 nucleotide binding
1.59 2.10e-07 GO:0004672 protein kinase activity
1.69 4.47e-07 GO:0019904 protein domain specific binding
1.69 4.71e-07 GO:0004674 protein serine/threonine kinase activity
1.31 4.77e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.83 1.55e-06 GO:0008134 transcription factor binding
1.49 3.60e-06 GO:0019899 enzyme binding
1.43 6.49e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.26 6.80e-06 GO:0003677 DNA binding
1.94 1.15e-05 GO:0000975 regulatory region DNA binding
1.94 1.15e-05 GO:0001067 regulatory region nucleic acid binding
1.94 1.15e-05 GO:0044212 transcription regulatory region DNA binding
1.77 1.43e-05 GO:0005083 small GTPase regulator activity
1.71 4.19e-05 GO:0016563 transcription activator activity
1.39 6.63e-05 GO:0030234 enzyme regulator activity
1.90 6.96e-05 GO:0010843 promoter binding
1.16 2.91e-04 GO:0046872 metal ion binding
2.00 4.04e-04 GO:0022843 voltage-gated cation channel activity
1.73 4.41e-04 GO:0005096 GTPase activator activity
1.28 5.28e-04 GO:0030554 adenyl nucleotide binding
1.16 5.54e-04 GO:0043169 cation binding
1.16 6.51e-04 GO:0043167 ion binding
1.71 1.15e-03 GO:0003702 RNA polymerase II transcription factor activity
1.27 1.20e-03 GO:0032559 adenyl ribonucleotide binding
1.56 1.26e-03 GO:0008047 enzyme activator activity
1.96 1.31e-03 GO:0005516 calmodulin binding
1.89 1.31e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.54 3.92e-03 GO:0000988 protein binding transcription factor activity
1.54 3.92e-03 GO:0000989 transcription factor binding transcription factor activity
1.44 4.73e-03 GO:0008092 cytoskeletal protein binding
2.09 5.46e-03 GO:0005249 voltage-gated potassium channel activity
1.37 5.53e-03 GO:0042802 identical protein binding
1.53 6.16e-03 GO:0003712 transcription cofactor activity
4.65 6.61e-03 GO:0030742 GTP-dependent protein binding
1.25 7.61e-03 GO:0005524 ATP binding
1.71 8.10e-03 GO:0003924 GTPase activity
1.21 9.62e-03 GO:0008270 zinc ion binding
1.61 9.95e-03 GO:0005261 cation channel activity
1.57 1.04e-02 GO:0016564 transcription repressor activity
1.57 1.19e-02 GO:0022836 gated channel activity
1.94 1.60e-02 GO:0015631 tubulin binding
1.15 2.25e-02 GO:0003676 nucleic acid binding
1.99 2.47e-02 GO:0005057 receptor signaling protein activity
2.52 2.85e-02 GO:0046332 SMAD binding
5.68 3.10e-02 GO:0019789 SUMO ligase activity
1.49 3.61e-02 GO:0005525 GTP binding
1.85 3.77e-02 GO:0005267 potassium channel activity
2.00 4.88e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity