Motif ID: EHF.p2

Z-value: 3.273


Transcription factors associated with EHF.p2:

Gene SymbolEntrez IDGene Name
EHF 26298 ets homologous factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EHFchr11_+_34642587,
chr11_+_34654010
-0.027.2e-01Click!


Activity profile for motif EHF.p2.

activity profile for motif EHF.p2


Sorted Z-values histogram for motif EHF.p2

Sorted Z-values for motif EHF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EHF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_203830723 90.557 SNRPE
small nuclear ribonucleoprotein polypeptide E
chr1_+_203830732 87.440 NM_003094
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr1_+_32688013 82.817 EIF3I
eukaryotic translation initiation factor 3, subunit I
chr1_+_32687970 82.531 NM_003757
EIF3I
eukaryotic translation initiation factor 3, subunit I
chr1_+_203830763 81.657 SNRPE
small nuclear ribonucleoprotein polypeptide E
chr1_+_32688053 80.942 EIF3I
eukaryotic translation initiation factor 3, subunit I
chr1_+_32688010 80.058 EIF3I
eukaryotic translation initiation factor 3, subunit I
chr12_-_110888079 78.743 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr12_-_110888106 77.080 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr12_-_110888098 71.099 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr12_-_110888160 66.967 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr1_+_84944919 66.787 NM_025065
RPF1
ribosome production factor 1 homolog (S. cerevisiae)
chr2_-_230786618 66.754 NM_004238
TRIP12
thyroid hormone receptor interactor 12
chr11_+_65769956 63.571 BANF1
barrier to autointegration factor 1
chr10_+_12238208 63.203 CDC123
cell division cycle 123 homolog (S. cerevisiae)
chr7_+_141438122 63.178 NM_003143
SSBP1
single-stranded DNA binding protein 1
chr12_-_110888134 61.313 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr20_-_2451355 59.893 SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr11_+_65769886 58.757 BANF1
barrier to autointegration factor 1
chr5_-_140070888 57.848 HARS
histidyl-tRNA synthetase
chr17_+_57784961 57.245 VMP1
vacuole membrane protein 1
chr21_-_33984865 56.634 NM_021254
C21orf59
chromosome 21 open reading frame 59
chr17_+_57785025 56.168 VMP1
vacuole membrane protein 1
chr14_+_35761543 53.988 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr17_+_57785011 53.935 VMP1
vacuole membrane protein 1
chr14_+_35761604 53.905 PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr1_-_43637788 52.103 EBNA1BP2
EBNA1 binding protein 2
chr7_-_7680048 51.198 RPA3
replication protein A3, 14kDa
chr11_+_65769773 50.834 BANF1
barrier to autointegration factor 1
chr10_+_12238179 50.764 CDC123
cell division cycle 123 homolog (S. cerevisiae)
chr22_+_39898365 50.736 SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr1_+_110091218 50.524 GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr17_+_57785059 50.044 VMP1
vacuole membrane protein 1
chr1_-_43637958 49.819 EBNA1BP2
EBNA1 binding protein 2
chr17_+_57785010 49.617 VMP1
vacuole membrane protein 1
chr12_+_69080722 48.841 NM_020401
NUP107
nucleoporin 107kDa
chr14_+_78174424 48.752 NM_031210
SLIRP
SRA stem-loop interacting RNA binding protein
chr9_+_127631388 48.537 ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr14_+_78174438 48.036 SLIRP
SRA stem-loop interacting RNA binding protein
chr17_-_57784756 47.874 NM_016077
PTRH2
peptidyl-tRNA hydrolase 2
chr5_+_110074740 46.943 NM_138773
SLC25A46
solute carrier family 25, member 46
chr17_+_57784862 46.941 NM_030938
VMP1
vacuole membrane protein 1
chr1_+_155178489 45.617 NM_002455
NM_198883
MTX1

metaxin 1

chr12_-_110888152 45.517 NM_005719
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr11_+_62529049 45.487 POLR2G
polymerase (RNA) II (DNA directed) polypeptide G
chr10_+_12238194 45.450 CDC123
cell division cycle 123 homolog (S. cerevisiae)
chr3_-_131221649 45.247 NM_007208
MRPL3
mitochondrial ribosomal protein L3
chr17_-_4851688 44.538 PFN1
profilin 1
chr9_-_127177689 43.981 NM_002799
PSMB7
proteasome (prosome, macropain) subunit, beta type, 7
chr1_-_43637969 43.496 NM_006824
NM_001159936
EBNA1BP2

EBNA1 binding protein 2

chr5_-_140070953 43.449 NM_002109
HARS
histidyl-tRNA synthetase
chr20_+_16710608 43.291 NM_003092
NM_198220
SNRPB2

small nuclear ribonucleoprotein polypeptide B

chr18_+_3453771 42.896 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr21_-_33984657 42.831 C21orf59
chromosome 21 open reading frame 59
chr22_-_36925212 42.302 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr1_+_155179005 42.294 MTX1
metaxin 1
chr1_-_165737987 41.835 TMCO1
transmembrane and coiled-coil domains 1
chr3_-_119396220 41.795 NM_005694
COX17
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr5_+_110074708 40.833 SLC25A46
solute carrier family 25, member 46
chr11_-_60673854 40.788 PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
chr1_+_113162456 40.531 CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chr1_+_113162449 40.360 CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chr7_+_44240569 40.133 NM_006555
YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr21_-_33984455 40.101 C21orf59
chromosome 21 open reading frame 59
chr15_-_59949536 40.087 NM_004492
GTF2A2
general transcription factor IIA, 2, 12kDa
chr5_+_140071220 40.049 HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr1_+_40723730 39.630 NM_005857
ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr17_-_17184589 39.536 NM_003653
COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr20_-_2451428 39.445 SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr22_-_36925138 39.200 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr22_-_36925270 39.081 NM_003753
EIF3D
eukaryotic translation initiation factor 3, subunit D
chr14_-_69864967 38.209 NM_004450
ERH
enhancer of rudimentary homolog (Drosophila)
chr17_-_61920328 38.068 NM_001098426
SMARCD2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr15_-_34394071 37.714 C15orf24
chromosome 15 open reading frame 24
chr1_+_40723838 37.133 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr2_-_99952779 36.974 NM_005783
TXNDC9
thioredoxin domain containing 9
chr1_-_20987881 36.894 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr20_+_55926299 36.642 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr19_+_9938555 36.410 NM_001048241
NM_024292
UBL5

ubiquitin-like 5

chr1_+_218458646 35.920 RRP15
ribosomal RNA processing 15 homolog (S. cerevisiae)
chr11_+_62529010 35.758 NM_002696
POLR2G
polymerase (RNA) II (DNA directed) polypeptide G
chr7_+_39663140 35.337 NM_005402
RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr10_+_43277953 35.195 NM_014753
BMS1
BMS1 homolog, ribosome assembly protein (yeast)
chr6_-_31704070 35.142 CLIC1
chloride intracellular channel 1
chr5_+_10250281 34.986 NM_012073
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr5_+_271775 34.971 PDCD6
programmed cell death 6
chr20_+_55926144 34.919 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr7_+_39663199 34.549 RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr7_+_44240606 34.226 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr13_+_29233279 34.203 POMP
proteasome maturation protein
chr2_+_233415300 34.049 NM_004846
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr7_+_44240555 33.868 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr1_+_40506449 33.797 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr18_+_657461 33.617 NM_001071
TYMS
thymidylate synthetase
chr20_+_34129833 33.524 ERGIC3
ERGIC and golgi 3
chr20_-_2451439 33.506 NM_003091
NM_198216
SNRPB

small nuclear ribonucleoprotein polypeptides B and B1

chr19_+_9938587 33.313 UBL5
ubiquitin-like 5
chr5_+_271764 33.055 PDCD6
programmed cell death 6
chr16_-_69373473 32.973 NM_032382
COG8
component of oligomeric golgi complex 8
chr11_+_65769409 32.951 NM_001143985
NM_003860
BANF1

barrier to autointegration factor 1

chr5_+_271700 32.832 NM_013232
PDCD6
programmed cell death 6
chr3_-_150264134 32.827 SERP1
stress-associated endoplasmic reticulum protein 1
chr1_+_161123755 32.823 UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr5_+_10250377 32.733 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr7_+_99006544 32.625 NM_003910
BUD31
BUD31 homolog (S. cerevisiae)
chr7_+_39663257 32.449 RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr6_-_31510251 32.421 NM_004640
NM_080598
DDX39B

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr22_-_36925175 32.312 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr1_-_43855448 32.010 MED8
mediator complex subunit 8
chrX_-_15872905 31.997


chr14_+_75348592 31.914 NM_001244883
NM_001933
DLST

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

chr5_+_10250410 31.909 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr6_-_31704093 31.834 CLIC1
chloride intracellular channel 1
chr12_+_53693454 31.832 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr3_+_172468469 31.694 ECT2
epithelial cell transforming sequence 2 oncogene
chr1_-_67896098 31.561 NM_001018067
NM_001018068
NM_001018069
NM_015640
SERBP1



SERPINE1 mRNA binding protein 1



chr11_+_32605337 31.402 EIF3M
eukaryotic translation initiation factor 3, subunit M
chr11_+_118889427 31.400 TRAPPC4
trafficking protein particle complex 4
chr2_+_177134122 31.229 NM_006554
MTX2
metaxin 2
chr10_+_43278222 31.012 BMS1
BMS1 homolog, ribosome assembly protein (yeast)
chr17_-_61920256 30.993 SMARCD2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chrX_-_153775427 30.884 G6PD
glucose-6-phosphate dehydrogenase
chr1_-_165738106 30.768 NM_019026
TMCO1
transmembrane and coiled-coil domains 1
chr7_+_99006650 30.623 BUD31
BUD31 homolog (S. cerevisiae)
chr11_-_64084980 30.612 NM_016404
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
chr7_+_44240638 30.551 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr3_-_196669247 30.507 NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr10_+_12237929 30.489 NM_006023
CDC123
cell division cycle 123 homolog (S. cerevisiae)
chrX_+_119737984 30.326 MCTS1
malignant T cell amplified sequence 1
chr1_-_20987984 30.165 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr1_-_20987896 30.101 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr6_-_31704287 30.091 CLIC1
chloride intracellular channel 1
chr11_-_65655837 30.080 NM_004214
NM_198897
FIBP

fibroblast growth factor (acidic) intracellular binding protein

chr6_-_31704304 29.890 CLIC1
chloride intracellular channel 1
chr20_+_60962120 29.697 NM_001024
RPS21
ribosomal protein S21
chr2_+_162164785 29.652 NM_005805
PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr6_-_31704281 29.619 CLIC1
chloride intracellular channel 1
chr1_+_40723864 29.521 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr6_-_31704318 29.413 NM_001288
CLIC1
chloride intracellular channel 1
chr6_-_31704272 29.398 CLIC1
chloride intracellular channel 1
chr5_+_10250370 29.333 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chrX_+_11129459 29.326 HCCS
holocytochrome c synthase
chr5_+_10250403 29.221 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr5_+_10250440 28.998 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr1_-_20987867 28.875 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr6_+_134274247 28.831 NM_004865
TBPL1
TBP-like 1
chr2_+_3622909 28.814 RPS7
ribosomal protein S7
chr8_-_48872682 28.671 PRKDC
protein kinase, DNA-activated, catalytic polypeptide
chr1_+_40723907 28.660 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr1_+_228270802 28.599 NM_001024227
NM_001024228
ARF1

ADP-ribosylation factor 1

chr11_+_118230348 28.400 UBE4A
ubiquitination factor E4A
chr3_-_196669373 28.400 NM_001042540
NM_007362
NCBP2

nuclear cap binding protein subunit 2, 20kDa

chr15_+_78832746 28.296 NM_001102667
NM_001102668
NM_002789
PSMA4


proteasome (prosome, macropain) subunit, alpha type, 4


chr1_-_19811951 28.248 CAPZB
capping protein (actin filament) muscle Z-line, beta
chr12_-_112847361 28.227 NM_000970
NM_001024662
RPL6

ribosomal protein L6

chr1_-_67896081 28.210 SERBP1
SERPINE1 mRNA binding protein 1
chr22_+_39898372 28.198 SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr17_-_48474910 28.102 NM_018509
LRRC59
leucine rich repeat containing 59
chr1_-_67896097 27.963 SERBP1
SERPINE1 mRNA binding protein 1
chr15_+_78832787 27.922 PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr17_+_49337892 27.902 NM_016001
UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr17_+_30771520 27.749 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_246729546 27.618 NM_022366
TFB2M
transcription factor B2, mitochondrial
chr3_-_112280764 27.613 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr6_-_31926628 27.609 NM_002904
RDBP
RD RNA binding protein
chr8_-_55014367 27.589 NM_006330
LYPLA1
lysophospholipase I
chr17_+_49337909 27.405 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr7_-_91875296 27.372 NM_194455
NM_194456
KRIT1

KRIT1, ankyrin repeat containing

chr13_+_29233140 27.309 NM_015932
POMP
proteasome maturation protein
chr17_-_48474678 27.265 LRRC59
leucine rich repeat containing 59
chr2_+_162164993 27.184 PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr22_+_39898354 27.104 SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr17_+_49337882 27.088 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr1_+_40506423 27.037 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr6_-_31509725 26.836 DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr12_-_93835714 26.780 UBE2N
ubiquitin-conjugating enzyme E2N
chr12_-_123380608 26.735


chrX_-_15872921 26.681 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_161123510 26.674 NM_016406
UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr22_+_39898288 26.589 SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr9_+_127631476 26.533 NM_030978
ARPC5L
actin related protein 2/3 complex, subunit 5-like
chrX_-_107334749 26.368 NM_002814
NM_170750
PSMD10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr12_-_93835723 26.366 UBE2N
ubiquitin-conjugating enzyme E2N
chrX_+_11129405 26.347 NM_001122608
NM_001171991
NM_005333
HCCS


holocytochrome c synthase


chr11_+_70049268 26.317 NM_003824
FADD
Fas (TNFRSF6)-associated via death domain
chrX_+_49028183 26.273 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr2_+_65454828 26.234 NM_001005386
NM_005722
ACTR2

ARP2 actin-related protein 2 homolog (yeast)

chr10_-_96122619 26.202 NM_022451
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr11_+_66247878 26.062 NM_005700
NM_130443
DPP3

dipeptidyl-peptidase 3

chr7_+_73097897 26.034 NM_001202560
NM_017528
WBSCR22

Williams Beuren syndrome chromosome region 22

chr20_+_55926585 25.969 NM_001015885
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr17_-_65362635 25.774 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr12_-_93835659 25.769 UBE2N
ubiquitin-conjugating enzyme E2N
chr14_+_77924367 25.728 NM_012111
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr5_+_33440801 25.569 NM_152295
TARS
threonyl-tRNA synthetase
chr7_+_73097930 25.427 WBSCR22
Williams Beuren syndrome chromosome region 22
chrX_+_69509878 25.422 NM_012310
KIF4A
kinesin family member 4A
chr11_-_60674039 25.374 NM_014502
PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
chr1_+_39456887 25.302 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr20_-_33872571 25.249 NM_002212
NM_181466
EIF6

eukaryotic translation initiation factor 6


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.60 5.64e-46 GO:0044260 cellular macromolecule metabolic process
1.45 4.03e-44 GO:0044237 cellular metabolic process
1.51 3.22e-39 GO:0043170 macromolecule metabolic process
1.74 3.44e-37 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 4.39e-36 GO:0008152 metabolic process
1.82 2.00e-34 GO:0090304 nucleic acid metabolic process
1.39 4.07e-34 GO:0044238 primary metabolic process
1.21 9.67e-34 GO:0009987 cellular process
1.89 2.21e-30 GO:0016070 RNA metabolic process
1.60 3.80e-29 GO:0034641 cellular nitrogen compound metabolic process
1.58 9.88e-29 GO:0006807 nitrogen compound metabolic process
1.83 1.14e-28 GO:0010467 gene expression
1.66 2.76e-26 GO:0044267 cellular protein metabolic process
2.63 3.51e-26 GO:0016071 mRNA metabolic process
1.80 3.77e-23 GO:0034645 cellular macromolecule biosynthetic process
1.78 1.44e-22 GO:0009059 macromolecule biosynthetic process
1.49 6.92e-22 GO:0071840 cellular component organization or biogenesis
2.34 7.51e-22 GO:0006396 RNA processing
3.53 1.12e-21 GO:0000375 RNA splicing, via transesterification reactions
3.02 1.65e-21 GO:0008380 RNA splicing
3.53 4.50e-21 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
3.53 4.50e-21 GO:0000398 nuclear mRNA splicing, via spliceosome
2.64 4.24e-20 GO:0016032 viral reproduction
1.55 5.61e-20 GO:0071841 cellular component organization or biogenesis at cellular level
2.92 6.98e-20 GO:0006412 translation
1.50 2.28e-18 GO:0019538 protein metabolic process
3.36 2.29e-18 GO:0022613 ribonucleoprotein complex biogenesis
2.09 4.27e-18 GO:0046907 intracellular transport
2.61 4.55e-18 GO:0006397 mRNA processing
1.46 6.23e-18 GO:0016043 cellular component organization
3.19 7.75e-17 GO:0071843 cellular component biogenesis at cellular level
2.18 2.56e-16 GO:0009057 macromolecule catabolic process
1.98 3.62e-16 GO:0015031 protein transport
1.53 7.92e-16 GO:0044249 cellular biosynthetic process
1.50 8.94e-16 GO:0071842 cellular component organization at cellular level
1.95 2.56e-15 GO:0045184 establishment of protein localization
1.83 6.68e-15 GO:0008104 protein localization
1.65 1.13e-14 GO:0006996 organelle organization
2.23 2.55e-14 GO:0006974 response to DNA damage stimulus
2.21 2.79e-14 GO:0044265 cellular macromolecule catabolic process
1.49 4.73e-14 GO:0009058 biosynthetic process
1.66 5.00e-13 GO:0009056 catabolic process
1.68 1.09e-12 GO:0033036 macromolecule localization
1.74 3.72e-12 GO:0051649 establishment of localization in cell
1.68 6.57e-12 GO:0051641 cellular localization
1.70 1.82e-11 GO:0044248 cellular catabolic process
2.03 2.83e-11 GO:0000278 mitotic cell cycle
2.38 4.76e-11 GO:0051603 proteolysis involved in cellular protein catabolic process
2.31 5.07e-11 GO:0030163 protein catabolic process
1.82 7.05e-11 GO:0033554 cellular response to stress
3.32 9.73e-11 GO:0042254 ribosome biogenesis
2.33 1.55e-10 GO:0044257 cellular protein catabolic process
3.42 2.12e-10 GO:0051320 S phase
2.37 2.33e-10 GO:0006511 ubiquitin-dependent protein catabolic process
1.72 2.49e-10 GO:0007049 cell cycle
2.35 2.57e-10 GO:0019941 modification-dependent protein catabolic process
2.34 3.80e-10 GO:0043632 modification-dependent macromolecule catabolic process
3.40 5.08e-10 GO:0000084 S phase of mitotic cell cycle
1.65 5.38e-10 GO:0044085 cellular component biogenesis
2.95 5.61e-10 GO:0010498 proteasomal protein catabolic process
2.95 5.61e-10 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.78 1.18e-09 GO:0043933 macromolecular complex subunit organization
3.73 2.08e-09 GO:2000045 regulation of G1/S transition of mitotic cell cycle
3.81 2.12e-09 GO:0000216 M/G1 transition of mitotic cell cycle
2.32 3.02e-09 GO:0051325 interphase
2.33 3.36e-09 GO:0051329 interphase of mitotic cell cycle
1.90 3.42e-09 GO:0051726 regulation of cell cycle
1.81 3.48e-09 GO:0016192 vesicle-mediated transport
2.56 4.26e-09 GO:0071156 regulation of cell cycle arrest
3.71 5.13e-09 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
2.57 7.48e-09 GO:0000075 cell cycle checkpoint
2.95 7.61e-09 GO:0000082 G1/S transition of mitotic cell cycle
3.67 7.87e-09 GO:0022618 ribonucleoprotein complex assembly
2.12 1.11e-08 GO:0006886 intracellular protein transport
1.83 1.11e-08 GO:0022403 cell cycle phase
3.56 1.11e-08 GO:0030330 DNA damage response, signal transduction by p53 class mediator
3.70 1.26e-08 GO:0031575 mitotic cell cycle G1/S transition checkpoint
3.70 1.26e-08 GO:0071779 G1/S transition checkpoint
2.19 1.47e-08 GO:0010564 regulation of cell cycle process
2.98 1.60e-08 GO:0048193 Golgi vesicle transport
3.96 3.17e-08 GO:0071158 positive regulation of cell cycle arrest
3.85 3.25e-08 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
3.18 3.97e-08 GO:0042770 signal transduction in response to DNA damage
1.97 4.16e-08 GO:0034621 cellular macromolecular complex subunit organization
3.45 5.91e-08 GO:0071826 ribonucleoprotein complex subunit organization
3.52 6.57e-08 GO:0051351 positive regulation of ligase activity
3.58 7.17e-08 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.77 8.20e-08 GO:0012501 programmed cell death
1.72 8.59e-08 GO:0022402 cell cycle process
1.77 1.15e-07 GO:0006915 apoptosis
1.92 1.16e-07 GO:0034613 cellular protein localization
3.69 1.23e-07 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.68 1.60e-07 GO:0008219 cell death
1.91 1.72e-07 GO:0070727 cellular macromolecule localization
3.25 2.20e-07 GO:0051340 regulation of ligase activity
1.67 2.36e-07 GO:0016265 death
3.07 2.44e-07 GO:0031398 positive regulation of protein ubiquitination
3.30 2.59e-07 GO:0051438 regulation of ubiquitin-protein ligase activity
3.52 2.61e-07 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.12 2.84e-07 GO:0006521 regulation of cellular amino acid metabolic process
3.87 3.17e-07 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.87 3.17e-07 GO:0072395 signal transduction involved in cell cycle checkpoint
3.87 3.17e-07 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.87 3.17e-07 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.87 3.17e-07 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.87 3.17e-07 GO:0072422 signal transduction involved in DNA damage checkpoint
3.87 3.17e-07 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.87 3.17e-07 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
3.62 4.62e-07 GO:0051352 negative regulation of ligase activity
3.62 4.62e-07 GO:0051444 negative regulation of ubiquitin-protein ligase activity
3.65 7.46e-07 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
3.97 7.70e-07 GO:0046782 regulation of viral transcription
2.23 8.96e-07 GO:0034660 ncRNA metabolic process
1.94 9.07e-07 GO:0016044 cellular membrane organization
2.38 1.14e-06 GO:0009203 ribonucleoside triphosphate catabolic process
2.38 1.14e-06 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.93 1.18e-06 GO:0061024 membrane organization
2.35 1.26e-06 GO:0009261 ribonucleotide catabolic process
2.36 1.39e-06 GO:0009146 purine nucleoside triphosphate catabolic process
1.61 1.43e-06 GO:0032774 RNA biosynthetic process
2.82 1.60e-06 GO:0007093 mitotic cell cycle checkpoint
2.21 1.72e-06 GO:0007346 regulation of mitotic cell cycle
1.79 1.80e-06 GO:0006259 DNA metabolic process
4.10 1.81e-06 GO:0050434 positive regulation of viral transcription
2.12 2.42e-06 GO:0009141 nucleoside triphosphate metabolic process
1.40 2.46e-06 GO:0043412 macromolecule modification
2.33 2.50e-06 GO:0009143 nucleoside triphosphate catabolic process
2.33 2.50e-06 GO:0009154 purine ribonucleotide catabolic process
3.66 2.96e-06 GO:0048524 positive regulation of viral reproduction
3.45 3.71e-06 GO:0050792 regulation of viral reproduction
2.13 3.76e-06 GO:0009199 ribonucleoside triphosphate metabolic process
2.86 4.40e-06 GO:0031570 DNA integrity checkpoint
2.11 5.18e-06 GO:0009144 purine nucleoside triphosphate metabolic process
4.37 5.86e-06 GO:0006413 translational initiation
3.15 6.67e-06 GO:0006415 translational termination
2.10 8.20e-06 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.76 8.48e-06 GO:0071822 protein complex subunit organization
2.60 9.18e-06 GO:0031396 regulation of protein ubiquitination
3.11 9.23e-06 GO:0031397 negative regulation of protein ubiquitination
2.89 9.44e-06 GO:0000077 DNA damage checkpoint
2.10 9.60e-06 GO:0006366 transcription from RNA polymerase II promoter
3.16 1.12e-05 GO:0019080 viral genome expression
3.16 1.12e-05 GO:0019083 viral transcription
1.68 1.29e-05 GO:0065003 macromolecular complex assembly
1.39 1.55e-05 GO:0006464 protein modification process
2.15 1.87e-05 GO:0009166 nucleotide catabolic process
2.19 1.98e-05 GO:0006195 purine nucleotide catabolic process
2.42 2.14e-05 GO:0043687 post-translational protein modification
2.18 2.35e-05 GO:0032269 negative regulation of cellular protein metabolic process
3.41 3.56e-05 GO:0033238 regulation of cellular amine metabolic process
1.50 4.67e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.53 4.72e-05 GO:0042981 regulation of apoptosis
2.13 4.73e-05 GO:0051248 negative regulation of protein metabolic process
2.78 4.75e-05 GO:0032984 macromolecular complex disassembly
2.78 4.75e-05 GO:0034623 cellular macromolecular complex disassembly
3.19 5.28e-05 GO:0006353 transcription termination, DNA-dependent
1.52 5.35e-05 GO:0010941 regulation of cell death
2.14 5.42e-05 GO:0072523 purine-containing compound catabolic process
2.85 5.97e-05 GO:0006414 translational elongation
1.95 6.27e-05 GO:0006281 DNA repair
1.52 8.20e-05 GO:0032268 regulation of cellular protein metabolic process
2.22 8.44e-05 GO:0033365 protein localization to organelle
1.96 8.57e-05 GO:0009259 ribonucleotide metabolic process
1.51 8.59e-05 GO:0043067 regulation of programmed cell death
1.50 8.76e-05 GO:0051246 regulation of protein metabolic process
2.85 1.01e-04 GO:0043241 protein complex disassembly
2.85 1.01e-04 GO:0043624 cellular protein complex disassembly
1.97 1.02e-04 GO:0009150 purine ribonucleotide metabolic process
2.28 1.13e-04 GO:0022411 cellular component disassembly
2.28 1.13e-04 GO:0071845 cellular component disassembly at cellular level
1.94 1.29e-04 GO:0070647 protein modification by small protein conjugation or removal
1.47 1.38e-04 GO:0031325 positive regulation of cellular metabolic process
2.52 1.41e-04 GO:0019058 viral infectious cycle
2.38 1.56e-04 GO:0022415 viral reproductive process
1.45 1.90e-04 GO:0009893 positive regulation of metabolic process
3.35 2.05e-04 GO:0006368 transcription elongation from RNA polymerase II promoter
1.27 2.08e-04 GO:0006810 transport
2.88 2.16e-04 GO:0006364 rRNA processing
2.01 2.59e-04 GO:0032446 protein modification by small protein conjugation
1.27 2.97e-04 GO:0051234 establishment of localization
2.00 2.99e-04 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
2.00 2.99e-04 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
2.66 3.72e-04 GO:0090068 positive regulation of cell cycle process
2.56 4.37e-04 GO:0031018 endocrine pancreas development
1.48 4.58e-04 GO:0022607 cellular component assembly
1.99 4.62e-04 GO:0010608 posttranscriptional regulation of gene expression
3.84 4.78e-04 GO:0006283 transcription-coupled nucleotide-excision repair
2.31 5.59e-04 GO:0031400 negative regulation of protein modification process
2.15 5.77e-04 GO:0006605 protein targeting
4.37 6.25e-04 GO:0006903 vesicle targeting
4.37 6.25e-04 GO:0009452 RNA capping
3.74 7.46e-04 GO:0006369 termination of RNA polymerase II transcription
5.24 7.62e-04 GO:0048199 vesicle targeting, to, from or within Golgi
2.72 8.30e-04 GO:0016072 rRNA metabolic process
1.80 8.32e-04 GO:0006091 generation of precursor metabolites and energy
1.83 1.19e-03 GO:0044419 interspecies interaction between organisms
1.23 1.22e-03 GO:0051179 localization
4.73 1.23e-03 GO:0006901 vesicle coating
3.00 1.24e-03 GO:2000243 positive regulation of reproductive process
1.31 1.26e-03 GO:0048523 negative regulation of cellular process
1.98 1.50e-03 GO:0016567 protein ubiquitination
2.34 1.51e-03 GO:0031016 pancreas development
1.29 1.73e-03 GO:0048519 negative regulation of biological process
2.87 1.76e-03 GO:0006354 transcription elongation, DNA-dependent
1.28 1.85e-03 GO:0048522 positive regulation of cellular process
1.76 2.02e-03 GO:0051247 positive regulation of protein metabolic process
3.00 2.09e-03 GO:0072594 establishment of protein localization to organelle
4.54 2.29e-03 GO:0006900 membrane budding
4.22 2.76e-03 GO:0006370 mRNA capping
1.79 2.80e-03 GO:0016568 chromatin modification
2.96 2.82e-03 GO:0006200 ATP catabolic process
1.79 3.13e-03 GO:0034622 cellular macromolecular complex assembly
1.86 3.18e-03 GO:0031401 positive regulation of protein modification process
1.85 4.06e-03 GO:0044270 cellular nitrogen compound catabolic process
1.79 4.35e-03 GO:0051301 cell division
4.08 4.63e-03 GO:0000387 spliceosomal snRNP assembly
1.62 4.77e-03 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
2.96 4.77e-03 GO:0016050 vesicle organization
2.36 4.95e-03 GO:0045333 cellular respiration
1.65 5.06e-03 GO:0006753 nucleoside phosphate metabolic process
1.65 5.06e-03 GO:0009117 nucleotide metabolic process
1.85 5.39e-03 GO:0046700 heterocycle catabolic process
1.75 5.40e-03 GO:0032270 positive regulation of cellular protein metabolic process
1.58 5.57e-03 GO:0005975 carbohydrate metabolic process
2.11 7.63e-03 GO:0006913 nucleocytoplasmic transport
1.69 8.09e-03 GO:0072521 purine-containing compound metabolic process
1.88 8.37e-03 GO:0015980 energy derivation by oxidation of organic compounds
1.57 9.79e-03 GO:0051276 chromosome organization
1.25 1.02e-02 GO:0048518 positive regulation of biological process
2.08 1.05e-02 GO:0051169 nuclear transport
2.36 1.09e-02 GO:0017038 protein import
2.83 1.12e-02 GO:0006289 nucleotide-excision repair
1.67 1.15e-02 GO:0044262 cellular carbohydrate metabolic process
3.30 1.31e-02 GO:0006418 tRNA aminoacylation for protein translation
3.30 1.31e-02 GO:0043038 amino acid activation
3.30 1.31e-02 GO:0043039 tRNA aminoacylation
2.23 1.37e-02 GO:0010565 regulation of cellular ketone metabolic process
1.95 1.56e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.70 1.61e-02 GO:0006163 purine nucleotide metabolic process
3.71 1.87e-02 GO:0000245 spliceosome assembly
2.14 2.10e-02 GO:0046039 GTP metabolic process
1.25 2.12e-02 GO:0006950 response to stress
6.80 2.20e-02 GO:0048194 Golgi vesicle budding
6.80 2.20e-02 GO:0048200 Golgi transport vesicle coating
6.80 2.20e-02 GO:0048205 COPI coating of Golgi vesicle
3.33 2.21e-02 GO:0051650 establishment of vesicle localization
1.30 2.70e-02 GO:0044281 small molecule metabolic process
2.56 2.93e-02 GO:0051656 establishment of organelle localization
1.44 3.40e-02 GO:0006351 transcription, DNA-dependent
3.36 3.70e-02 GO:0006888 ER to Golgi vesicle-mediated transport
1.41 3.72e-02 GO:0009892 negative regulation of metabolic process
1.77 3.92e-02 GO:0048285 organelle fission
1.57 4.04e-02 GO:0044282 small molecule catabolic process
1.71 4.17e-02 GO:0018193 peptidyl-amino acid modification
2.05 4.69e-02 GO:0006417 regulation of translation
2.31 4.78e-02 GO:2000241 regulation of reproductive process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.35e-73 GO:0044424 intracellular part
1.26 6.45e-69 GO:0005622 intracellular
1.32 9.47e-60 GO:0043226 organelle
1.32 1.22e-59 GO:0043229 intracellular organelle
1.36 1.16e-58 GO:0043227 membrane-bounded organelle
1.36 1.16e-58 GO:0043231 intracellular membrane-bounded organelle
1.54 1.71e-56 GO:0044446 intracellular organelle part
1.53 1.33e-55 GO:0044422 organelle part
1.36 2.68e-53 GO:0005737 cytoplasm
1.93 5.05e-45 GO:0044428 nuclear part
1.44 1.25e-42 GO:0044444 cytoplasmic part
1.63 2.89e-40 GO:0032991 macromolecular complex
1.82 1.38e-38 GO:0031974 membrane-enclosed lumen
1.92 1.12e-36 GO:0031981 nuclear lumen
1.81 1.46e-36 GO:0070013 intracellular organelle lumen
1.80 4.17e-36 GO:0043233 organelle lumen
1.42 9.08e-34 GO:0005634 nucleus
2.79 6.70e-32 GO:0030529 ribonucleoprotein complex
1.78 3.89e-31 GO:0005829 cytosol
1.89 9.03e-24 GO:0005654 nucleoplasm
1.51 1.60e-20 GO:0043234 protein complex
1.49 2.78e-17 GO:0043228 non-membrane-bounded organelle
1.49 2.78e-17 GO:0043232 intracellular non-membrane-bounded organelle
1.54 1.44e-15 GO:0031090 organelle membrane
1.07 2.72e-15 GO:0044464 cell part
1.07 2.90e-15 GO:0005623 cell
3.33 7.12e-13 GO:0005681 spliceosomal complex
2.12 8.20e-13 GO:0005730 nucleolus
1.90 5.30e-12 GO:0031967 organelle envelope
1.88 1.09e-11 GO:0031975 envelope
1.62 1.39e-11 GO:0005739 mitochondrion
4.16 5.31e-10 GO:0000502 proteasome complex
3.65 3.68e-09 GO:0071013 catalytic step 2 spliceosome
1.77 7.92e-09 GO:0044451 nucleoplasm part
2.54 4.03e-08 GO:0005840 ribosome
1.75 1.02e-07 GO:0044429 mitochondrial part
2.35 1.09e-07 GO:0016604 nuclear body
1.46 1.63e-07 GO:0012505 endomembrane system
2.69 5.34e-06 GO:0016607 nuclear speck
2.16 5.50e-06 GO:0005635 nuclear envelope
3.44 1.12e-05 GO:0015934 large ribosomal subunit
1.94 1.33e-05 GO:0019866 organelle inner membrane
2.41 1.98e-05 GO:0044445 cytosolic part
1.96 2.23e-05 GO:0005743 mitochondrial inner membrane
4.51 2.61e-05 GO:0030532 small nuclear ribonucleoprotein complex
1.77 3.06e-05 GO:0005740 mitochondrial envelope
1.79 3.23e-05 GO:0031966 mitochondrial membrane
3.07 4.47e-05 GO:0022626 cytosolic ribosome
1.46 3.05e-04 GO:0005794 Golgi apparatus
3.78 5.69e-04 GO:0022625 cytosolic large ribosomal subunit
1.62 6.08e-04 GO:0005694 chromosome
2.40 6.29e-04 GO:0044455 mitochondrial membrane part
6.05 8.69e-04 GO:0005852 eukaryotic translation initiation factor 3 complex
2.91 1.22e-03 GO:0030117 membrane coat
2.91 1.22e-03 GO:0048475 coated membrane
2.23 1.43e-03 GO:0031965 nuclear membrane
3.07 2.39e-03 GO:0005798 Golgi-associated vesicle
3.18 8.39e-03 GO:0015030 Cajal body
1.87 1.32e-02 GO:0000228 nuclear chromosome
3.55 1.34e-02 GO:0030660 Golgi-associated vesicle membrane
1.47 1.37e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.46 2.14e-02 GO:0005789 endoplasmic reticulum membrane
1.55 2.94e-02 GO:0044427 chromosomal part
1.90 3.04e-02 GO:0005819 spindle
1.35 3.14e-02 GO:0005783 endoplasmic reticulum
1.42 3.15e-02 GO:0044432 endoplasmic reticulum part
3.14 3.36e-02 GO:0030120 vesicle coat
4.37 3.45e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.67 3.82e-02 GO:0030496 midbody

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.41 1.08e-50 GO:0005515 protein binding
2.27 1.21e-27 GO:0003723 RNA binding
1.14 3.08e-19 GO:0005488 binding
1.43 1.17e-10 GO:0000166 nucleotide binding
1.42 1.57e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.40 5.87e-07 GO:0032553 ribonucleotide binding
1.40 5.87e-07 GO:0032555 purine ribonucleotide binding
1.40 6.82e-07 GO:0017076 purine nucleotide binding
2.62 9.38e-07 GO:0003735 structural constituent of ribosome
3.24 1.63e-06 GO:0008135 translation factor activity, nucleic acid binding
1.63 2.69e-06 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.62 3.52e-06 GO:0016817 hydrolase activity, acting on acid anhydrides
1.62 3.80e-06 GO:0016462 pyrophosphatase activity
1.64 3.93e-06 GO:0017111 nucleoside-triphosphatase activity
1.19 1.03e-05 GO:0003824 catalytic activity
3.82 1.37e-05 GO:0003743 translation initiation factor activity
1.38 1.22e-04 GO:0005524 ATP binding
1.37 2.72e-04 GO:0032559 adenyl ribonucleotide binding
1.36 4.18e-04 GO:0030554 adenyl nucleotide binding
1.22 7.76e-04 GO:0003676 nucleic acid binding
1.65 2.53e-03 GO:0016874 ligase activity
3.38 2.61e-03 GO:0004812 aminoacyl-tRNA ligase activity
3.38 2.61e-03 GO:0016875 ligase activity, forming carbon-oxygen bonds
3.38 2.61e-03 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
1.72 6.55e-03 GO:0016887 ATPase activity