Motif ID: EP300.p2

Z-value: 1.750


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_41487787-0.211.6e-03Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_4851688 32.663 PFN1
profilin 1
chr17_-_4851797 28.459 NM_005022
PFN1
profilin 1
chr6_-_86352656 27.280 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr12_+_6309475 26.621 NM_001769
CD9
CD9 molecule
chr6_-_86352696 25.782 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr17_-_4851827 25.320 PFN1
profilin 1
chr6_-_86352650 24.533 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr6_-_86352564 23.074 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr6_-_86352635 19.353 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr14_-_69446038 18.989 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr1_+_156084579 18.174 LMNA
lamin A/C
chr1_-_108742963 17.798 NM_013386
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr14_-_69446008 17.243 ACTN1
actinin, alpha 1
chr11_+_1968586 17.160 MRPL23
mitochondrial ribosomal protein L23
chr14_-_69445948 17.069 ACTN1
actinin, alpha 1
chr14_-_69445989 17.061 ACTN1
actinin, alpha 1
chr14_-_69445978 16.998 ACTN1
actinin, alpha 1
chr13_-_99229037 16.843 STK24
serine/threonine kinase 24
chr14_-_69445974 16.203 ACTN1
actinin, alpha 1
chr1_-_20987881 15.969 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr2_+_217498082 15.008 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr11_-_67188614 13.767 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr1_-_8939150 13.452 NM_001428
ENO1
enolase 1, (alpha)
chrX_+_23685613 12.690 PRDX4
peroxiredoxin 4
chrX_+_23685658 12.575 PRDX4
peroxiredoxin 4
chrX_+_23685637 12.393 NM_006406
PRDX4
peroxiredoxin 4
chr12_-_58146025 12.381 CDK4
cyclin-dependent kinase 4
chr2_-_3605918 11.896 RNASEH1
ribonuclease H1
chr3_+_49711751 11.829 APEH
N-acylaminoacyl-peptide hydrolase
chr1_-_20987960 11.766 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr7_+_116164838 11.679 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chrX_+_118602362 11.546 NM_001152
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr12_-_58146118 11.543 NM_000075
CDK4
cyclin-dependent kinase 4
chr1_-_20988023 11.496 NM_005216
DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr1_-_20987984 11.362 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr16_+_69373414 11.358 NM_001199434
NM_016101
NIP7

nuclear import 7 homolog (S. cerevisiae)

chr16_-_69373406 11.326 COG8
component of oligomeric golgi complex 8
chr5_+_95998678 11.303 CAST
calpastatin
chrX_+_118602391 11.098 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr7_+_150756753 11.086 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr1_-_20987896 11.009 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr7_+_116165043 10.984 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr3_+_179280746 10.939 ACTL6A
actin-like 6A
chr6_-_86352982 10.796 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr1_-_20987867 10.692 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr10_+_121411071 10.687 BAG3
BCL2-associated athanogene 3
chr1_-_108742738 10.653 SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr12_-_53298765 10.630 NM_002273
KRT8
keratin 8
chr2_-_65357048 10.525 RAB1A
RAB1A, member RAS oncogene family
chr15_+_23810808 10.439 MKRN3
makorin ring finger protein 3
chr14_+_75348592 10.381 NM_001244883
NM_001933
DLST

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

chr11_+_75110552 10.365 NM_001005
RPS3
ribosomal protein S3
chr11_-_64014381 10.294 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_154947147 10.277 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr16_+_67261010 10.223 NM_014187
TMEM208
transmembrane protein 208
chr3_-_49066858 10.216 NM_000884
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr1_+_154947116 10.143 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr1_+_154947166 10.119 CKS1B
CDC28 protein kinase regulatory subunit 1B
chrX_+_21958714 10.082 NM_004595
SMS
spermine synthase
chr17_+_15848230 9.985 NM_000676
ADORA2B
adenosine A2b receptor
chr2_-_110371404 9.941 SEPT10
septin 10
chr3_+_100428133 9.875 NM_001007565
NM_001195479
NM_006070
TFG


TRK-fused gene


chr3_-_49066760 9.866 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr1_-_20987937 9.750 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr5_+_72794247 9.687 NM_001037637
NM_001207
BTF3

basic transcription factor 3

chr19_+_16187315 9.667 TPM4
tropomyosin 4
chr7_-_45960738 9.648 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr2_+_233415300 9.635 NM_004846
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr3_-_195808934 9.623 TFRC
transferrin receptor (p90, CD71)
chr13_-_99229117 9.585 STK24
serine/threonine kinase 24
chr7_+_116165089 9.542 CAV1
caveolin 1, caveolae protein, 22kDa
chr8_-_103667882 9.528 NM_005655
KLF10
Kruppel-like factor 10
chr14_-_38064440 9.517 NM_004496
FOXA1
forkhead box A1
chr5_+_72794273 9.464 BTF3
basic transcription factor 3
chr5_+_34684611 9.407 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr7_+_150756645 9.316 NM_003040
SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr1_+_116184573 9.185 NM_001172411
NM_138959
VANGL1

vang-like 1 (van gogh, Drosophila)

chr7_+_150756716 9.166 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr14_-_69445772 9.136 ACTN1
actinin, alpha 1
chr1_-_8938745 9.110 ENO1
enolase 1, (alpha)
chr16_-_69373473 9.099 NM_032382
COG8
component of oligomeric golgi complex 8
chr11_-_64084980 9.076 NM_016404
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
chr3_-_49066813 8.970 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr14_+_23340955 8.965 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr3_-_195808958 8.960 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr3_-_195808997 8.950 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr4_-_84256012 8.852 NM_001098540
HPSE
heparanase
chr2_-_3605849 8.826 RNASEH1
ribonuclease H1
chr1_-_197115566 8.745 NM_001206846
NM_018136
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr1_-_8938727 8.741 ENO1
enolase 1, (alpha)
chr11_+_65769409 8.723 NM_001143985
NM_003860
BANF1

barrier to autointegration factor 1

chr8_+_22224758 8.710 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr1_+_165796652 8.678 NM_012474
UCK2
uridine-cytidine kinase 2
chr13_-_99229226 8.660 NM_001032296
STK24
serine/threonine kinase 24
chr11_+_35160385 8.630 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr4_+_62066945 8.593 LPHN3
latrophilin 3
chr3_+_49711816 8.573 APEH
N-acylaminoacyl-peptide hydrolase
chr10_-_126849556 8.533 NM_001083914
CTBP2
C-terminal binding protein 2
chr2_-_3605926 8.447 NM_002936
RNASEH1
ribonuclease H1
chr3_+_100428393 8.445 TFG
TRK-fused gene
chr19_-_42806460 8.441 NM_002573
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr5_+_892950 8.403 NM_001166260
NM_004237
TRIP13

thyroid hormone receptor interactor 13

chrX_-_53449548 8.393 SMC1A
structural maintenance of chromosomes 1A
chr11_-_134094418 8.370 NM_015261
NCAPD3
non-SMC condensin II complex, subunit D3
chr19_-_48894755 8.362 NM_006801
KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr2_+_201171411 8.262 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr8_+_22224786 8.217 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr12_-_110888134 8.216 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr10_-_5931800 8.210 NM_001009941
NM_001009943
NM_019046
ANKRD16


ankyrin repeat domain 16


chr1_+_236558715 8.189 NM_080738
EDARADD
EDAR-associated death domain
chr1_+_116185249 8.174 NM_001172412
VANGL1
vang-like 1 (van gogh, Drosophila)
chr11_+_114167197 8.167 NNMT
nicotinamide N-methyltransferase
chr1_-_225840660 8.100 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr4_-_80994183 8.091


chr1_+_26606580 8.047 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr10_-_43892675 8.034 HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr1_-_16482426 8.025 NM_004431
EPHA2
EPH receptor A2
chr2_+_71295685 7.945 NAGK
N-acetylglucosamine kinase
chr17_+_38137185 7.942 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr20_-_22564893 7.936 FOXA2
forkhead box A2
chr1_+_200860619 7.896 NM_018265
C1orf106
chromosome 1 open reading frame 106
chr2_-_110371669 7.876 NM_144710
NM_178584
SEPT10

septin 10

chr15_-_76603806 7.871 NM_000126
NM_001127716
ETFA

electron-transfer-flavoprotein, alpha polypeptide

chr3_+_100428361 7.847 NM_001195478
TFG
TRK-fused gene
chrX_-_153599581 7.839 FLNA
filamin A, alpha
chr14_-_55658205 7.830 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr2_+_74153931 7.825 NM_080916
NM_080918
DGUOK

deoxyguanosine kinase

chr1_-_184943673 7.794 NM_052966
FAM129A
family with sequence similarity 129, member A
chr2_+_217498205 7.774 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr1_-_8938691 7.753 ENO1
enolase 1, (alpha)
chr11_+_1968499 7.640 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr19_+_48828820 7.629 EMP3
epithelial membrane protein 3
chr1_+_212209129 7.576 DTL
denticleless homolog (Drosophila)
chr12_-_124118197 7.568 NM_001414
EIF2B1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr19_+_10982369 7.534 CARM1
coactivator-associated arginine methyltransferase 1
chr11_-_62607043 7.530 WDR74
WD repeat domain 74
chr17_+_49230938 7.525 NME1
NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in
NME1-NME2 readthrough
chr9_-_117880411 7.517 NM_002160
TNC
tenascin C
chr2_+_74153987 7.504 DGUOK
deoxyguanosine kinase
chr3_+_49711434 7.497 NM_001640
APEH
N-acylaminoacyl-peptide hydrolase
chr6_-_31704287 7.439 CLIC1
chloride intracellular channel 1
chr7_+_148892553 7.432 NM_003575
ZNF282
zinc finger protein 282
chr15_-_76603728 7.306 ETFA
electron-transfer-flavoprotein, alpha polypeptide
chr2_+_85804689 7.279 VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr6_-_31698033 7.241 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr6_-_31704070 7.191 CLIC1
chloride intracellular channel 1
chr6_-_31704093 7.160 CLIC1
chloride intracellular channel 1
chr3_+_179280738 7.122 ACTL6A
actin-like 6A
chr12_-_49319211 7.100 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chrX_-_153599719 7.071 FLNA
filamin A, alpha
chr15_-_76603791 7.070 ETFA
electron-transfer-flavoprotein, alpha polypeptide
chr7_+_143078358 7.064 NM_001010972
NM_003461
ZYX

zyxin

chr5_+_132387579 7.026 NM_002154
HSPA4
heat shock 70kDa protein 4
chr12_-_109125289 7.019 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr11_-_93276513 7.015 NM_020179
C11orf75
chromosome 11 open reading frame 75
chr5_+_132387699 7.001 HSPA4
heat shock 70kDa protein 4
chr1_+_40723838 6.992 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr1_+_40723907 6.990 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr1_+_156084541 6.987 LMNA
lamin A/C
chr7_+_39663257 6.969 RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr5_+_132387734 6.957 HSPA4
heat shock 70kDa protein 4
chr1_+_26606621 6.931 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr1_+_26606586 6.929 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr19_-_55918980 6.873 UBE2S
ubiquitin-conjugating enzyme E2S
chr2_+_172778907 6.866 NM_003642
HAT1
histone acetyltransferase 1
chr1_+_40723864 6.850 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr2_+_85804613 6.847 NM_003761
VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr2_+_172778973 6.810 HAT1
histone acetyltransferase 1
chr6_-_31697953 6.805 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr1_+_156084565 6.803 LMNA
lamin A/C
chr19_+_19627018 6.795 NM_015965
NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr17_+_37026351 6.783 LASP1
LIM and SH3 protein 1
chr14_-_23398605 6.776 NM_001039619
NM_006109
PRMT5

protein arginine methyltransferase 5

chr17_+_49230896 6.766 NM_000269
NM_198175
NM_001018136
NME1

NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in

NME1-NME2 readthrough
chr16_+_85646923 6.761 NM_014615
KIAA0182
KIAA0182
chr17_+_49230929 6.749 NME1
non-metastatic cells 1, protein (NM23A) expressed in
chr2_+_74154015 6.741 DGUOK
deoxyguanosine kinase
chr11_+_46403279 6.731 MDK
midkine (neurite growth-promoting factor 2)
chr5_+_68530736 6.664 CDK7
cyclin-dependent kinase 7
chr17_+_49230954 6.617 NME1
NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in
NME1-NME2 readthrough
chr2_-_161349874 6.611 RBMS1
RNA binding motif, single stranded interacting protein 1
chr20_-_49547451 6.611 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr9_-_35103089 6.542 STOML2
stomatin (EPB72)-like 2
chr11_+_46403260 6.541 MDK
midkine (neurite growth-promoting factor 2)
chr1_+_224544550 6.514 CNIH4
cornichon homolog 4 (Drosophila)
chr3_-_50360109 6.508 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr11_+_46403205 6.505 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr15_+_22892683 6.498 NM_014608
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr2_+_110371887 6.495 NM_023016
ANKRD57
ankyrin repeat domain 57
chr11_+_65769956 6.492 BANF1
barrier to autointegration factor 1
chr11_+_46403302 6.471 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr2_+_192109879 6.469 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chrX_-_100662788 6.461 GLA
galactosidase, alpha
chr6_+_43738394 6.456 VEGFA
vascular endothelial growth factor A
chr3_+_172468469 6.451 ECT2
epithelial cell transforming sequence 2 oncogene
chr5_+_68530713 6.437 CDK7
cyclin-dependent kinase 7
chr6_-_18264638 6.423 NM_001134709
NM_003472
DEK

DEK oncogene

chr7_+_56019552 6.405 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr9_+_138392473 6.402 NM_016034
MRPS2
mitochondrial ribosomal protein S2
chr1_+_224544590 6.394 NM_014184
CNIH4
cornichon homolog 4 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 3.03e-39 GO:0009987 cellular process
1.40 2.08e-37 GO:0044237 cellular metabolic process
1.35 3.80e-35 GO:0008152 metabolic process
1.37 1.61e-32 GO:0044238 primary metabolic process
1.47 8.81e-31 GO:0044260 cellular macromolecule metabolic process
1.43 1.33e-29 GO:0043170 macromolecule metabolic process
1.54 3.04e-26 GO:0006807 nitrogen compound metabolic process
1.53 6.76e-25 GO:0034641 cellular nitrogen compound metabolic process
1.57 1.93e-23 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 9.52e-22 GO:0016070 RNA metabolic process
1.69 2.09e-21 GO:0010467 gene expression
1.61 1.78e-20 GO:0090304 nucleic acid metabolic process
1.45 5.66e-20 GO:0071840 cellular component organization or biogenesis
1.52 8.03e-19 GO:0071841 cellular component organization or biogenesis at cellular level
1.44 2.66e-18 GO:0016043 cellular component organization
1.50 1.09e-16 GO:0071842 cellular component organization at cellular level
1.50 5.41e-16 GO:0044267 cellular protein metabolic process
1.43 1.76e-14 GO:0019538 protein metabolic process
1.47 1.18e-13 GO:0048522 positive regulation of cellular process
1.44 1.52e-13 GO:0048518 positive regulation of biological process
1.58 6.09e-13 GO:0034645 cellular macromolecule biosynthetic process
1.46 1.40e-12 GO:0044249 cellular biosynthetic process
1.56 3.15e-12 GO:0009059 macromolecule biosynthetic process
2.21 8.25e-12 GO:0016032 viral reproduction
1.19 3.50e-11 GO:0065007 biological regulation
1.42 7.33e-11 GO:0009058 biosynthetic process
2.01 9.63e-11 GO:0016071 mRNA metabolic process
1.43 2.21e-10 GO:0048519 negative regulation of biological process
1.45 4.04e-10 GO:0048523 negative regulation of cellular process
1.19 1.01e-09 GO:0050789 regulation of biological process
1.85 3.14e-09 GO:0006396 RNA processing
1.59 1.26e-08 GO:0044085 cellular component biogenesis
2.22 1.83e-08 GO:0006412 translation
1.19 2.23e-08 GO:0050794 regulation of cellular process
2.54 6.38e-08 GO:0022411 cellular component disassembly
2.54 6.38e-08 GO:0071845 cellular component disassembly at cellular level
1.47 7.48e-08 GO:0006996 organelle organization
1.68 8.60e-08 GO:0043933 macromolecular complex subunit organization
1.57 1.17e-07 GO:0044248 cellular catabolic process
1.60 4.67e-07 GO:0032774 RNA biosynthetic process
1.87 5.43e-07 GO:0034621 cellular macromolecular complex subunit organization
1.42 9.26e-07 GO:0044281 small molecule metabolic process
1.76 1.91e-06 GO:0071822 protein complex subunit organization
1.47 1.98e-06 GO:0009056 catabolic process
1.51 3.44e-06 GO:0031325 positive regulation of cellular metabolic process
1.54 3.45e-06 GO:0051246 regulation of protein metabolic process
1.94 3.83e-06 GO:0006397 mRNA processing
1.57 4.11e-06 GO:0009892 negative regulation of metabolic process
1.29 5.65e-06 GO:0048856 anatomical structure development
1.25 6.61e-06 GO:0032502 developmental process
1.49 7.10e-06 GO:0009893 positive regulation of metabolic process
1.71 7.11e-06 GO:0051726 regulation of cell cycle
2.04 9.00e-06 GO:0008380 RNA splicing
1.56 1.14e-05 GO:0042127 regulation of cell proliferation
1.54 1.17e-05 GO:0032268 regulation of cellular protein metabolic process
1.74 1.18e-05 GO:0050878 regulation of body fluid levels
1.57 1.22e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.50 1.30e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.95 1.93e-05 GO:0010564 regulation of cell cycle process
1.52 2.16e-05 GO:0042981 regulation of apoptosis
1.51 2.90e-05 GO:0022607 cellular component assembly
1.51 4.10e-05 GO:0043067 regulation of programmed cell death
1.80 4.65e-05 GO:0008283 cell proliferation
1.50 4.67e-05 GO:0010941 regulation of cell death
1.55 5.41e-05 GO:0031324 negative regulation of cellular metabolic process
1.26 6.15e-05 GO:0060255 regulation of macromolecule metabolic process
1.51 6.95e-05 GO:0007049 cell cycle
1.23 8.89e-05 GO:0019222 regulation of metabolic process
2.67 9.18e-05 GO:0032984 macromolecular complex disassembly
2.67 9.18e-05 GO:0034623 cellular macromolecular complex disassembly
1.45 9.20e-05 GO:0051641 cellular localization
1.66 9.27e-05 GO:0009057 macromolecule catabolic process
1.48 1.11e-04 GO:0051649 establishment of localization in cell
2.75 1.64e-04 GO:0043241 protein complex disassembly
2.75 1.64e-04 GO:0043624 cellular protein complex disassembly
1.66 1.80e-04 GO:0042060 wound healing
2.00 2.01e-04 GO:0007346 regulation of mitotic cell cycle
1.23 3.58e-04 GO:0031323 regulation of cellular metabolic process
1.24 3.61e-04 GO:0007275 multicellular organismal development
1.91 3.81e-04 GO:0051325 interphase
1.92 4.27e-04 GO:0051329 interphase of mitotic cell cycle
1.55 4.40e-04 GO:0046907 intracellular transport
2.28 4.64e-04 GO:0022415 viral reproductive process
1.33 5.02e-04 GO:0043412 macromolecule modification
1.67 5.49e-04 GO:0044265 cellular macromolecule catabolic process
1.53 5.50e-04 GO:0051128 regulation of cellular component organization
1.33 6.97e-04 GO:0048513 organ development
1.26 7.00e-04 GO:0048731 system development
2.32 7.93e-04 GO:0034330 cell junction organization
1.69 7.94e-04 GO:0007596 blood coagulation
1.69 7.94e-04 GO:0050817 coagulation
1.57 7.99e-04 GO:0065003 macromolecular complex assembly
1.63 9.12e-04 GO:0000278 mitotic cell cycle
1.55 1.02e-03 GO:0071844 cellular component assembly at cellular level
2.35 1.05e-03 GO:0019058 viral infectious cycle
1.68 1.09e-03 GO:0007599 hemostasis
1.50 1.14e-03 GO:0006351 transcription, DNA-dependent
2.58 1.32e-03 GO:0006414 translational elongation
1.33 1.34e-03 GO:0006464 protein modification process
2.10 1.45e-03 GO:0022613 ribonucleoprotein complex biogenesis
1.96 1.54e-03 GO:0051248 negative regulation of protein metabolic process
2.07 1.57e-03 GO:0000375 RNA splicing, via transesterification reactions
1.66 1.82e-03 GO:0009967 positive regulation of signal transduction
1.51 2.07e-03 GO:0022402 cell cycle process
1.44 2.26e-03 GO:0010646 regulation of cell communication
1.64 2.31e-03 GO:0008284 positive regulation of cell proliferation
2.66 2.48e-03 GO:0006415 translational termination
1.47 2.58e-03 GO:0050793 regulation of developmental process
2.03 3.02e-03 GO:0071843 cellular component biogenesis at cellular level
1.22 3.02e-03 GO:0080090 regulation of primary metabolic process
1.80 3.19e-03 GO:0009259 ribonucleotide metabolic process
1.63 3.30e-03 GO:0023056 positive regulation of signaling
1.89 3.34e-03 GO:0034660 ncRNA metabolic process
1.36 3.47e-03 GO:0009653 anatomical structure morphogenesis
2.25 3.57e-03 GO:0031016 pancreas development
1.82 3.61e-03 GO:0009150 purine ribonucleotide metabolic process
1.45 3.63e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.69 3.63e-03 GO:0043069 negative regulation of programmed cell death
1.50 3.85e-03 GO:0031399 regulation of protein modification process
2.66 3.97e-03 GO:0019080 viral genome expression
2.66 3.97e-03 GO:0019083 viral transcription
2.16 4.29e-03 GO:0031400 negative regulation of protein modification process
1.93 4.45e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.62 4.56e-03 GO:0010647 positive regulation of cell communication
1.69 4.60e-03 GO:0043066 negative regulation of apoptosis
1.75 5.00e-03 GO:0016568 chromatin modification
1.96 5.33e-03 GO:0071156 regulation of cell cycle arrest
1.80 5.93e-03 GO:0001501 skeletal system development
1.48 6.15e-03 GO:0033554 cellular response to stress
1.66 6.58e-03 GO:0060548 negative regulation of cell death
1.28 6.66e-03 GO:0065008 regulation of biological quality
2.01 6.93e-03 GO:0006457 protein folding
1.87 7.28e-03 GO:0001568 blood vessel development
1.71 7.30e-03 GO:0006091 generation of precursor metabolites and energy
2.25 9.23e-03 GO:0034329 cell junction assembly
1.56 9.30e-03 GO:0010629 negative regulation of gene expression
2.00 1.05e-02 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.00 1.05e-02 GO:0000398 nuclear mRNA splicing, via spliceosome
2.17 1.19e-02 GO:0000082 G1/S transition of mitotic cell cycle
1.51 1.25e-02 GO:0022403 cell cycle phase
1.50 1.29e-02 GO:0006915 apoptosis
1.46 1.34e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.76 1.37e-02 GO:0033043 regulation of organelle organization
2.97 1.41e-02 GO:0046782 regulation of viral transcription
1.49 1.67e-02 GO:0012501 programmed cell death
1.78 2.04e-02 GO:0006366 transcription from RNA polymerase II promoter
1.92 2.06e-02 GO:0000075 cell cycle checkpoint
1.44 2.07e-02 GO:0009891 positive regulation of biosynthetic process
2.23 2.26e-02 GO:0042254 ribosome biogenesis
1.44 2.27e-02 GO:0008219 cell death
2.25 2.39e-02 GO:0031018 endocrine pancreas development
1.77 2.59e-02 GO:0009144 purine nucleoside triphosphate metabolic process
1.80 2.63e-02 GO:0010608 posttranscriptional regulation of gene expression
1.46 2.71e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.52 2.74e-02 GO:0051276 chromosome organization
1.49 2.86e-02 GO:0009790 embryo development
1.43 2.97e-02 GO:0016265 death
2.77 2.98e-02 GO:0048524 positive regulation of viral reproduction
1.59 3.01e-02 GO:0070271 protein complex biogenesis
1.52 3.12e-02 GO:0009725 response to hormone stimulus
1.75 3.24e-02 GO:0022603 regulation of anatomical structure morphogenesis
3.00 3.62e-02 GO:0050434 positive regulation of viral transcription
1.74 3.63e-02 GO:0031401 positive regulation of protein modification process
1.35 3.68e-02 GO:0010033 response to organic substance
1.76 3.72e-02 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.77 3.76e-02 GO:0001944 vasculature development
1.79 3.80e-02 GO:0015980 energy derivation by oxidation of organic compounds
1.46 4.16e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.75 4.18e-02 GO:0009199 ribonucleoside triphosphate metabolic process
1.46 4.40e-02 GO:2000026 regulation of multicellular organismal development
1.66 4.57e-02 GO:0009792 embryo development ending in birth or egg hatching

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 7.56e-41 GO:0044424 intracellular part
1.20 2.86e-38 GO:0005622 intracellular
1.30 3.65e-37 GO:0005737 cytoplasm
1.35 3.91e-28 GO:0044444 cytoplasmic part
1.36 3.14e-27 GO:0044422 organelle part
1.37 3.19e-27 GO:0044446 intracellular organelle part
1.63 4.50e-25 GO:0031974 membrane-enclosed lumen
1.63 1.42e-24 GO:0043233 organelle lumen
1.63 8.47e-24 GO:0070013 intracellular organelle lumen
1.20 3.29e-23 GO:0043226 organelle
1.46 3.45e-23 GO:0032991 macromolecular complex
1.20 5.77e-23 GO:0043229 intracellular organelle
1.64 1.01e-22 GO:0005829 cytosol
1.62 2.45e-22 GO:0044428 nuclear part
1.21 8.29e-20 GO:0043227 membrane-bounded organelle
1.21 1.26e-19 GO:0043231 intracellular membrane-bounded organelle
1.62 3.84e-18 GO:0031981 nuclear lumen
1.42 1.14e-14 GO:0043234 protein complex
1.26 1.72e-13 GO:0005634 nucleus
1.41 7.95e-13 GO:0043228 non-membrane-bounded organelle
1.41 7.95e-13 GO:0043232 intracellular non-membrane-bounded organelle
1.60 9.42e-12 GO:0005654 nucleoplasm
1.06 1.28e-11 GO:0044464 cell part
1.06 1.36e-11 GO:0005623 cell
2.00 1.77e-11 GO:0030529 ribonucleoprotein complex
1.83 1.70e-07 GO:0005730 nucleolus
1.58 4.56e-05 GO:0031967 organelle envelope
1.39 1.19e-04 GO:0005739 mitochondrion
1.55 1.29e-04 GO:0031975 envelope
1.95 3.64e-04 GO:0005635 nuclear envelope
1.52 5.56e-04 GO:0044451 nucleoplasm part
2.57 8.50e-04 GO:0042470 melanosome
2.57 8.50e-04 GO:0048770 pigment granule
2.91 1.91e-03 GO:0030496 midbody
2.03 3.72e-03 GO:0070161 anchoring junction
1.74 5.71e-03 GO:0015629 actin cytoskeleton
2.54 8.94e-03 GO:0022626 cytosolic ribosome
2.03 1.04e-02 GO:0005912 adherens junction
1.45 1.63e-02 GO:0044429 mitochondrial part
2.19 1.74e-02 GO:0030055 cell-substrate junction
2.20 2.24e-02 GO:0005924 cell-substrate adherens junction
2.23 2.39e-02 GO:0005925 focal adhesion
1.87 2.92e-02 GO:0031252 cell leading edge
1.97 4.23e-02 GO:0031965 nuclear membrane
4.67 4.37e-02 GO:0030684 preribosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.41 1.79e-56 GO:0005515 protein binding
1.16 4.48e-27 GO:0005488 binding
1.70 4.10e-09 GO:0003723 RNA binding
1.18 4.61e-05 GO:0003824 catalytic activity
1.24 7.48e-03 GO:0000166 nucleotide binding
1.78 8.50e-03 GO:0032403 protein complex binding
1.54 8.96e-03 GO:0008092 cytoskeletal protein binding
2.55 8.99e-03 GO:0003729 mRNA binding
1.43 2.16e-02 GO:0019899 enzyme binding
2.00 2.99e-02 GO:0003735 structural constituent of ribosome
1.59 4.32e-02 GO:0003712 transcription cofactor activity
1.46 4.51e-02 GO:0005198 structural molecule activity
1.59 4.73e-02 GO:0000988 protein binding transcription factor activity
1.59 4.73e-02 GO:0000989 transcription factor binding transcription factor activity